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1. Assessment and Management of Appetite Loss in Older Adults: An ICFSR Task Force Report

Author

de Souto Barreto, Philipe, Cesari, M., Morley, J. E., Gonzalez-Bautista, E., Rolland, Y., Azzolino, D., Vellas, B., Fielding, R. A., Andrieu, Sandrine, Leheudre, Mylène Aubertin, Barcons, Nuria, Beliën, Ann, Delannoy, Carla, John, Groarke, Robledo, Luis Miguel Gutierrez, Hwee, Darren, LeBrasseur, Nathan, Mariani, Jean, Reshma, Merchant, Pereira, Suzette, Erin, Quann, Michelle, Rossulek, Rueda, Ricardo, Sourdet, Sandrine, Tarasenko, Lisa, Tourette, Cendrine, Van Maanen, Rob, Waters, Debra L., and Whitson, Heather

Published
2023
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10. International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines

Author

Izquierdo, Mikel, Merchant, R. A., Morley, J. E., Anker, S. D., Aprahamian, I., Arai, H., Aubertin-Leheudre, M., Bernabei, R., Cadore, E. L., Cesari, M., Chen, L.-K., de Souto Barreto, P., Duque, G., Ferrucci, L., Fielding, R. A., García-Hermoso, A., Gutiérrez-Robledo, L. M., Harridge, S. D. R., Kirk, B., Kritchevsky, S., Landi, F., Lazarus, N., Martin, F. C., Marzetti, E., Pahor, M., Ramírez-Vélez, R., Rodriguez-Mañas, L., Rolland, Y., Ruiz, J. G., Theou, O., Villareal, D. T., Waters, D. L., Won, C. Won, Woo, J., Vellas, B., and Singh, M. Fiatarone

Published
2021
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18. Physical Frailty: ICFSR International Clinical Practice Guidelines for Identification and Management

Author

Dent, E., Morley, J. E., Cruz-Jentoft, A. J., Woodhouse, L., Rodríguez-Mañas, L., Fried, L. P., Woo, J., Aprahamian, I., Sanford, A., Lundy, J., Landi, F., Beilby, J., Martin, F. C., Bauer, J. M., Ferrucci, L., Merchant, R. A., Dong, B., Arai, H., Hoogendijk, E. O., Won, C. W., Abbatecola, A., Cederholm, T., Strandberg, T., Gutiérrez Robledo, L. M., Flicker, L., Bhasin, S., Aubertin-Leheudre, M., Bischoff-Ferrari, H. A., Guralnik, J. M., Muscedere, J., Pahor, M., Ruiz, J., Negm, A. M., Reginster, J. Y., Waters, D. L., and Vellas, B.

Published
2019
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19. International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management

Author

Dent, Elsa, Morley, J. E., Cruz-Jentoft, A. J., Arai, H., Kritchevsky, S. B., Guralnik, J., Bauer, J. M., Pahor, M., Clark, B. C., Cesari, M., Ruiz, J., Sieber, C. C., Aubertin-Leheudre, M., Waters, D. L., Visvanathan, R., Landi, F., Villareal, D. T., Fielding, R., Won, C. W., Theou, O., Martin, F. C., Dong, B., Woo, J., Flicker, L., Ferrucci, L., Merchant, R. A., Cao, L., Cederholm, T., Ribeiro, S. M. L., Rodríguez-Mañas, L., Anker, S. D., Lundy, J., Gutiérrez Robledo, L. M., Bautmans, I., Aprahamian, I., Schols, J. M. G. A., Izquierdo, M., and Vellas, B.

Published
2018
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28. Sex-specific muscle and metabolic biomarkers associated with gait speed and cognitive transitions in older adults: a 9-year follow-up

Author

Waters, D. L., Vlietstra, L., Qualls, C., Morley, J. E., and Vellas, B.

Abstract

Physical frailty and cognitive frailty share biological mechanisms, but sex-specific biomarkers associated with transitions in gait speed and cognition during ageing are poorly understood.Gait speed, cognition (3MSE), body composition (DXA) and serological biomarkers were assessed annually over 9 years in 216 males (72.7 + 8.07 years) and 384 females (71.1 +8.44 years). In females, maintaining normal gait speed was associated with lower percent body fat (IRR 0.793, p= 0.001, 95%CI 0.691–0.910) and lower lactate dehydrogenase (LDH) (IRR 0.623, p = 0.00, 95%CI 0.514–0.752), and in males, the association was with higher cholesterol (IRR 1.394, p= 0.001, 95%CI 1.154–1.684). Abnormal to normal gait speed transitions were associated with higher insulin in females (IRR 1.325, p= 0.022, 95%CI 1.041–1.685) and lower creatinine in males (IRR 0.520, p= 0.01, 95%CI 0.310–0.870). Normal to slow gait speed transitions in males were associated with IGF-1 (IRR 1.74, p= 0.022, 95%CI 1.08–2.79) and leptin in females (IRR 1.39, p= 0.043, 95%CI 1.01–1.91.) Maintaining normal cognition was associated with lower LDH in females (IRR 0.276, p= 0.013, 95%CI 0.099–0.765) and higher appendicular skeletal muscle mass in males (IRR 1.52, p= 0.02, 95%CI 1.076–2.135). Improved cognition was associated with higher leptin (IRR 7.5, p= 0.03, 95%CI 1.282–44.34) and lower triglyceride (IRR 0.299, p= 0.017, 95%CI 0.110–0.809) in males. Education was protective against cognitive decline in females (IRR 0.84, p= 0.037, 0.732–0.982). Sex-specific biomarkers of muscle (LDH, Creatinine, IGF-1, APSM) and metabolism (%fat, insulin,cholesterol, leptin, tryglycerides) were associated with gait speed and cognitive transitions. These data suggest that modifiable biomarkers of muscle and metabolism could be targeted for interventions.

Published
2024
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32. Appetite Loss and Anorexia of Aging in Clinical Care : An ICFSR Task Force Report

Author

de Souto Barreto, P., Cesari, M., Morley, J. E., Roberts, S., Landi, F., Cederholm, Tommy, Rolland, Y., Vellas, B., Fielding, R., de Souto Barreto, P., Cesari, M., Morley, J. E., Roberts, S., Landi, F., Cederholm, Tommy, Rolland, Y., Vellas, B., and Fielding, R.

Abstract

Appetite lossianorexia of aging is a highly prevalent and burdensome geriatric syndrome that strongly impairs the quality of life of older adults. Loss of appetite is associated with several clinical conditions, including comorbidities and other geriatric syndromes, such as frailty. Despite its importance, appetite loss has been under-evaluated and, consequently, under-diagnosed and under-treated in routine clinical care. The International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force met virtually on September 27th 2021 to debate issues related to appetite loss/anorexia of aging. In particular, topics related to the implementation and management of appetite loss in at-risk older adult populations, energy balance during aging, and the design of future clinical trials on this topic were discussed. Future actions in this field should focus on the systematic assessment of appetite in the care pathway of older people, such as the Integrated Care for Older People (ICOPE) program recommended by the World Health Organization. Moreover, clinical care should move from the assessment to the treatment of appetite loss/anorexia. Researchers continue to pursue their efforts to find out effective pharmacologic and non-pharmacologic interventions with a favorable risk/benefit ratio.

Published
2022
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43. The primary care physician and Alzheimer’s disease: An international position paper

Author

Villars, H., Oustric, S., Andrieu, S., Baeyens, J. P., Bernabei, R., Brodaty, H., Brummel-Smith, K., Celafu, C., Chappell, N., Fitten, J., Frisoni, G., Froelich, L., Guerin, O., Gold, G., Holmerova, I., Iliffe, S., Lukas, A., Melis, R., Morley, J. E., Nies, H., Nourhashemi, F., Petermans, J., Ribera Casado, J., Rubenstein, L., Salva, A., Sieber, C., Sinclair, A., Schindler, R., Stephan, E., Wong, R. Y., and Vellas, B.

Published
2010
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49. International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines

Author

Izquierdo, M., Merchant, R. A., Morley, J. E., Anker, S. D., Aprahamian, I., Arai, H., Aubertin-Leheudre, M., Bernabei, R., Cadore, E. L., Cesari, M., Chen, L. -K., de Souto Barreto, P., Duque, G., Ferrucci, L., Fielding, R. A., Garcia-Hermoso, A., Gutierrez-Robledo, L. M., Harridge, S. D. R., Kirk, B., Kritchevsky, S., Landi, F., Lazarus, N., Martin, F. C., Marzetti, E., Pahor, M., Ramirez-Velez, R., Rodriguez-Manas, L., Rolland, Y., Ruiz, J. G., Theou, O., Villareal, D. T., Waters, D. L., Won, C. W., Woo, J., Vellas, B., Singh, M. F., Bernabei R. (ORCID:0000-0002-9197-004X), Landi F. (ORCID:0000-0002-3472-1389), Marzetti E. (ORCID:0000-0001-9567-6983), Izquierdo, M., Merchant, R. A., Morley, J. E., Anker, S. D., Aprahamian, I., Arai, H., Aubertin-Leheudre, M., Bernabei, R., Cadore, E. L., Cesari, M., Chen, L. -K., de Souto Barreto, P., Duque, G., Ferrucci, L., Fielding, R. A., Garcia-Hermoso, A., Gutierrez-Robledo, L. M., Harridge, S. D. R., Kirk, B., Kritchevsky, S., Landi, F., Lazarus, N., Martin, F. C., Marzetti, E., Pahor, M., Ramirez-Velez, R., Rodriguez-Manas, L., Rolland, Y., Ruiz, J. G., Theou, O., Villareal, D. T., Waters, D. L., Won, C. W., Woo, J., Vellas, B., Singh, M. F., Bernabei R. (ORCID:0000-0002-9197-004X), Landi F. (ORCID:0000-0002-3472-1389), and Marzetti E. (ORCID:0000-0001-9567-6983)

Abstract

The human ageing process is universal, ubiquitous and inevitable. Every physiological function is being continuously diminished. There is a range between two distinct phenotypes of ageing, shaped by patterns of living - experiences and behaviours, and in particular by the presence or absence of physical activity (PA) and structured exercise (i.e., a sedentary lifestyle). Ageing and a sedentary lifestyle are associated with declines in muscle function and cardiorespiratory fitness, resulting in an impaired capacity to perform daily activities and maintain independent functioning. However, in the presence of adequate exercise/PA these changes in muscular and aerobic capacity with age are substantially attenuated. Additionally, both structured exercise and overall PA play important roles as preventive strategies for many chronic diseases, including cardiovascular disease, stroke, diabetes, osteoporosis, and obesity; improvement of mobility, mental health, and quality of life; and reduction in mortality, among other benefits. Notably, exercise intervention programmes improve the hallmarks of frailty (low body mass, strength, mobility, PA level, energy) and cognition, thus optimising functional capacity during ageing. In these pathological conditions exercise is used as a therapeutic agent and follows the precepts of identifying the cause of a disease and then using an agent in an evidence-based dose to eliminate or moderate the disease. Prescription of PA/structured exercise should therefore be based on the intended outcome (e.g., primary prevention, improvement in fitness or functional status or disease treatment), and individualised, adjusted and controlled like any other medical treatment. In addition, in line with other therapeutic agents, exercise shows a dose-response effect and can be individualised using different modalities, volumes and/or intensities as appropriate to the health state or medical condition. Importantly, exercise therapy is often directed at sev

Published
2021

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