74 results on '"Morizot G"'
Search Results
2. Sustainable Development in the Non-Energy Extractive Industry : Southern Caucasus case The European Union Approach Some tools for the Promotion of Sustainable Development in the Non-Energy Extractive Industry
- Author
-
Morizot, G., Tvalchrelidze, Alexander G., editor, and Morizot, Georges, editor
- Published
- 2002
- Full Text
- View/download PDF
3. Travelers With Cutaneous Leishmaniasis Cured Without Systemic Therapy
- Author
-
Cutaneous Leishmaniasis French Study Group, Morizot, G., Kendjo, E., Mouri, O., Thellier, M., Pérignon, A., Foulet, F., Cordoliani, F., Bourrat, E., Laffitte, E., Alcaraz, I., Bodak, N., Ravel, C., Vray, M., Grogl, M., Mazier, D., Caumes, E., Lachaud, L., and Buffet, P. A.
- Published
- 2013
- Full Text
- View/download PDF
4. Estimating the burden of mucormycosis infections in France (2005–2007) through a capture-recapture method on laboratory and administrative data
- Author
-
Bitar, D., Morizot, G., Van Cauteren, D., DannaouI, E., Lanternier, F., Lortholary, O., and Dromer, F.
- Published
- 2012
- Full Text
- View/download PDF
5. A Global Analysis of Mucormycosis in France: The RetroZygo Study (2005-2007)
- Author
-
The French Mycosis Study Group, Lanternier, F., Dannaoui, E., Morizot, G., Elie, C., Garcia-Hermoso, D., Huerre, M., Bitar, D., Dromer, F., and Lortholary, O.
- Published
- 2012
- Full Text
- View/download PDF
6. Mineral Processing Technology Applied to the Remediation of Contaminated Soils
- Author
-
Morizot, G. J. P., Gallios, G. P., editor, and Matis, K. A., editor
- Published
- 1998
- Full Text
- View/download PDF
7. Positive impact of real-time expert advice on the care of patients with cutaneous leishmaniasis in France: 1.0-040
- Author
-
Buffet, P., Morizot, G., Kendjo, E., Bourrat, E., Chartrel, N., Ravel, C., Lachaud, L., Caumes, E., Mouri, O., and Thellier, M.
- Published
- 2011
8. Sustainable Development in the Non-Energy Extractive Industry
- Author
-
Morizot, G., primary
- Published
- 2003
- Full Text
- View/download PDF
9. Travelers With Cutaneous Leishmaniasis Cured Without Systemic Therapy
- Author
-
Morizot, G., Kendjo, E., Mouri, O., Thellier, M., Pérignon, A., Foulet, F., Cordoliani, F., Bourrat, E., Laffitte, E., Alcaraz, I., Bodak, N., Ravel, C., Vray, M., Grogl, M., Mazier, D., Caumes, E., Lachaud, L., Buffet, P. A., El Samad, Y., Salle, V., Gounod, N., Dallot, A., Belot, G., Pelletier-Cunat, S., Belon, M., Verdon, R., Rogeaux, O., Grossetête, G., Lesens, O., Clabaut, A., Maus, E., Jouy, L., Gener, G., Perrin, P., Roch, N., Herve, A., Le Duc, D., Cuchet, E., Maubon, D., Hillion, B., Menot, E., Guillemot, F., Beneton-Benhard, N., Celerier, P., Dupuis De Fonclare, A. L., Carre, D., Bourgeois, A., Marty, P., Pomares, C., Meunier, L., Abergel, H., Timsit, F., Amoric, J. C., Busquet, P., Karam, S., Moisson, Y. F., Mouly, F., Ortoli, J. C., Consigny, P. H., Jouan, M., Caby, F., Datry, A., Hochedez, P., Rozembaum, F., Dumortier, C., Ancelle, T., Dupin, N., Paugam, A., Ranque, B., Bougnoux, M. E., Canestri, A., Galezowsky, M. F., Hadj Rabia, S., Hamel, D., Schneider, P., Wolter-Desfosses, M., Janier, M., Baccard, M., Bezier, M., Broissin, M., Colin De Verdiere, N., Durupt, F., Hope Rapp, E., Juillard, C., Levy, A., Moraillon, I., Petit, A., Regner, S., Barthelme, D., Tamarin, J. M., Begon, E., Strady, C., Gangneux, J. P., Carpentier, O., Mechai, F., Kieffer, C., Dellestable, P., and Rebauder, S.
- Abstract
Guidelines recommend wound care and/or local therapy as first-line treatment for cutaneous leishmaniasis. An analysis of a referral treatment program in 135 travelers showed that this approach was feasible in 62% of patients, with positive outcome in 83% of evaluable patients
- Published
- 2017
10. Development in the use of column flotation: results of the European research project ImpexFlotCol.
- Author
-
Morizot G., XX International mineral processing congress Aachen 21-Sep-9726-Sep-97, Durance M.V., Morizot G., XX International mineral processing congress Aachen 21-Sep-9726-Sep-97, and Durance M.V.
- Abstract
The aim of the project is to improve the application of flotation columns. Work has been carried out at a laboratory, pilot and industrial scale. Results showed that the impact of gases other than air was less significant than expected, and had less impact than the physico-chemical conditions during grinding. Froth characteristics were found to play an important role in selectivity and recovery occurring in the froth layer; the detachment of foreign particles from the bubble surfaces occurred preferentially during bubble coalescence. A low pressure, high shear external bubble generator gave improved flexibility, better concentrate recovery and finer bubble production. Tests of flowsheets showed that columns are advantageous in a flotation circuit for liberated particles. They are well adapted to the cleaning function and even more to the roughing function if the particles to be floated are almost completely liberated in the pulp feeding the roughing stage., The aim of the project is to improve the application of flotation columns. Work has been carried out at a laboratory, pilot and industrial scale. Results showed that the impact of gases other than air was less significant than expected, and had less impact than the physico-chemical conditions during grinding. Froth characteristics were found to play an important role in selectivity and recovery occurring in the froth layer; the detachment of foreign particles from the bubble surfaces occurred preferentially during bubble coalescence. A low pressure, high shear external bubble generator gave improved flexibility, better concentrate recovery and finer bubble production. Tests of flowsheets showed that columns are advantageous in a flotation circuit for liberated particles. They are well adapted to the cleaning function and even more to the roughing function if the particles to be floated are almost completely liberated in the pulp feeding the roughing stage.
- Published
- 1997
11. Study of parameters which have influence on the froth flotation characteristics.
- Author
-
Gourram-Badri F., XX International mineral processing congress Aachen 21-Sep-9726-Sep-97, Conil P., Morizot G., Gourram-Badri F., XX International mineral processing congress Aachen 21-Sep-9726-Sep-97, Conil P., and Morizot G.
- Abstract
Flotation froth was studied in order to improve the efficiency of column flotation (mainly of complex sulphide ores) where characteristics of the froth zone (stability, fluidity, structure) directly affect the final recovery rate, grade and level of impurities. Cleaned zinc and copper concentrates from a Cu-Zn-pyrite orebody were used with MIBC as the frother. The impact on the flotation selectivity of each coalescence phenomenon between mineralised bubbles was demonstrated. Understanding of frother properties is a way to control this coalescence. A new method has been developed for quantifying the frother's ability to reduce bubble coalescence. The foaminess of the frother was also quantified both in the absence and in the presence of particles corresponding to two types of surface., Flotation froth was studied in order to improve the efficiency of column flotation (mainly of complex sulphide ores) where characteristics of the froth zone (stability, fluidity, structure) directly affect the final recovery rate, grade and level of impurities. Cleaned zinc and copper concentrates from a Cu-Zn-pyrite orebody were used with MIBC as the frother. The impact on the flotation selectivity of each coalescence phenomenon between mineralised bubbles was demonstrated. Understanding of frother properties is a way to control this coalescence. A new method has been developed for quantifying the frother's ability to reduce bubble coalescence. The foaminess of the frother was also quantified both in the absence and in the presence of particles corresponding to two types of surface.
- Published
- 1997
12. Selective Sn/Nb-Ta flotation: the impact of grinding conditions on the flotability of cassiterite.
- Author
-
Morizot G., XVIIth International Mineral Processing Congress Dresden, FRG 23-Sep-9128-Sep-91, Cichos C., Themeli G., Morizot G., XVIIth International Mineral Processing Congress Dresden, FRG 23-Sep-9128-Sep-91, Cichos C., and Themeli G.
- Abstract
The Beauvoir Kaolin Company at Echassieres in France produces a gravimetric heavy mineral concentrate from its waste rock containing cassiterite, columbotantalite and microlite. A new process to separate the tin and tantalum bearing minerals was developed using the phosphonic acid SPA; a commercially viable tin concentrate was prepared together with a tantalum concentrate. Iron contamination during grinding has a negative impact on the flotation process, as the tin recovery and grade drop by factors of 14 and 4 respectively., The Beauvoir Kaolin Company at Echassieres in France produces a gravimetric heavy mineral concentrate from its waste rock containing cassiterite, columbotantalite and microlite. A new process to separate the tin and tantalum bearing minerals was developed using the phosphonic acid SPA; a commercially viable tin concentrate was prepared together with a tantalum concentrate. Iron contamination during grinding has a negative impact on the flotation process, as the tin recovery and grade drop by factors of 14 and 4 respectively.
- Published
- 1991
13. Optimisation of the milling design of the Chessy project, near Lyon, France.
- Author
-
Morizot G., Mining industry optimisation conference MINOPT 91,Sydney 05-Jun-9106-Jun-91, Gallet M., Watsford R.M.S., Morizot G., Mining industry optimisation conference MINOPT 91,Sydney 05-Jun-9106-Jun-91, Gallet M., and Watsford R.M.S.
- Abstract
The Chessy project has demonstrated the potential of significantly improving a new mineral processing project, based on classical technology, through: the simplification of the comminution flowsheet with the use of SAG milling without critical size recirculation; the use of new technology, such as column flotation; and the use of second hand equipment for the most robust equipment items., The Chessy project has demonstrated the potential of significantly improving a new mineral processing project, based on classical technology, through: the simplification of the comminution flowsheet with the use of SAG milling without critical size recirculation; the use of new technology, such as column flotation; and the use of second hand equipment for the most robust equipment items.
- Published
- 1991
14. Liberation and its role in flotation-based flowsheet development
- Author
-
Morizot, G., primary, Conil, P., additional, Durance, M.V., additional, and Gourram Badri, F., additional
- Published
- 1997
- Full Text
- View/download PDF
15. Industrial needs of research in the field of flotation
- Author
-
Morizot, G., primary
- Published
- 1997
- Full Text
- View/download PDF
16. Measurements of selectivity due to coalescence between two mineralized bubbles and characterization of MIBC action on froth flotation
- Author
-
Gourram-Badri, F., primary, Conil, P., additional, and Morizot, G., additional
- Published
- 1997
- Full Text
- View/download PDF
17. Travelers With Cutaneous Leishmaniasis Cured Without Systemic Therapy.
- Author
-
Morizot, G., Kendjo, E., Mouri, O., Thellier, M., Pérignon, A., Foulet, F., Cordoliani, F., Bourrat, E., Laffitte, E., Alcaraz, I., Bodak, N., Ravel, C., Vray, M., Grogl, M., Mazier, D., Caumes, E., Lachaud, L., and Buffet, P. A.
- Subjects
- *
LEISHMANIASIS treatment , *TRAVEL hygiene , *ANTIPROTOZOAL agents , *AMPHOTERICIN B , *MEDICAL statistics - Abstract
Guidelines recommend wound care and/or local therapy as first-line treatment for cutaneous leishmaniasis. An analysis of a referral treatment program in 135 travelers showed that this approach was feasible in 62% of patients, with positive outcome in 83% of evaluable patients.Background. Cutaneous leishmaniasis (CL) is a disfiguring but not life-threatening disease. Because antileishmanial drugs are potentially toxic, the World Health Organization (WHO) recommends simple wound care or local therapy as first-line treatment, followed or replaced by systemic therapy if local therapy fails or cannot be performed.Methods. To determine the feasibility and impact of the recommended approach, we analyzed the results of a centralized referral treatment program in 135 patients with parasitologically proven CL.Results. Infections involved 10 Leishmania species and were contracted in 29 different countries. Eighty-four of 135 patients (62%) were initially treated without systemic therapy. Of 109 patients with evaluable charts, 23 of 25 (92%) treated with simple wound care and 37 of 47 (79%) treated with local antileishmanial therapy were cured by days 42–60. In 37 patients with large or complex lesions, or preexisting morbidities, or who had not been cured with local therapy, the cure rate with systemic antileishmanial agents was 60%. Systemic adverse events were observed in 15 patients, all receiving systemic therapy.Conclusions. In this population of CL patients displaying variable degrees of complexity and severity, almost two-thirds of patients could be initially managed without systemic therapy. Of these, 60 were cured before day 60. The WHO-recommended stepwise approach favoring initial local therapy therefore resulted in at least 44% of all patients being cured without exposure to the risk of systemic adverse events. Efforts are needed to further simplify local therapy of CL and to improve the management of patients with complex lesions and/or preexisting comorbidities. [ABSTRACT FROM AUTHOR]
- Published
- 2013
18. A process for the economic beneficiation of As- and AsAu-bearing antimony ores. Has the dream become a reality?
- Author
-
Morizot, G., primary and Ollivier, P., additional
- Published
- 1993
- Full Text
- View/download PDF
19. A Global Analysis of Mucormycosis in France: The RetroZygo Study (2005-2007).
- Author
-
Lanternier, F., Dannaoui, E., Morizot, G., Elie, C., Garcia-Hermoso, D., Huerre, M., Bitar, D., Dromer, F., and Lortholary, O.
- Subjects
MUCORMYCOSIS ,MYCOSES ,SYMPTOMS ,HEMATOLOGY ,ETIOLOGY of diseases ,AMPHOTERICIN B - Abstract
Background. Mucormycosis is a deadly invasive fungal infection whose characteristics are only partially understood. Methods. Data on mucormycosis obtained in France between 2005 and 2007 from 2 notification systems were merged. The 2008 European Organisation for Research and Treatment of Cancer/Mycoses Study Group definition criteria were applied and risk factors for death were analyzed by hazard ratios (HRs) calculated from the Cox proportional hazards regression model. Results. A total of 101 cases (60 proven, 41 probable), mostly in men (58%) .50 years (mean age, 50.7 ± 19.9) were recorded. Hematological malignancies represented 50% (median time for occurrence, 8.8 months after disease onset), diabetes 23%, and trauma 18% of cases. Sites of infection were lungs (28%; 79% in hematology patients), rhinocerebral (25%; 64% in diabetic patients), skin (20%), and disseminated (18%). Median time between first symptoms and diagnosis was 2 weeks. The main fungal species were Rhizopus oryzae (32%) and Lichtheimia species (29%). In cases where the causative species was identified, R. oryzae was present in 85% of rhinocerebral forms compared with only 17% of nonrhinocerebral forms (P <.001). Treatment consisted of surgery in 59% and antifungals in 87% of cases (liposomal amphotericin B in 61%). Ninety-day survival was 56%; it was reduced in cases of dissemination compared with rhinocerebral (HR, 5.38 [2.0-14.1]; P, .001), pulmonary (HR, 2.2 [1.0-4.7]; P = .04), or skin localization (HR, 5.73 [1.9-17.5]; P = .002); survival was reduced in cases of hematological malignancies compared with diabetes mellitus (HR, 2.3 [1.0-5.2]; P < .05) or trauma (HR, 6.9 [1.6-28.6], P =.008) and if ⩾2 underlying conditions (HR, 5.9 [1.8-19.0]; P = .004). Mucormycosis localization remained the only independent factor associated with survival. Conclusions. This 3-year study performed in one country shows the diverse clinical presentation of mucormycosis with a high prevalence of primary skin infection following trauma and a prognosis significantly influenced by localization. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
20. Proceedings of the XVIth International Mineral Processing Congress
- Author
-
Morizot, G., primary
- Published
- 1990
- Full Text
- View/download PDF
21. Polymetallic ore from Chessy: is it sometimes possible to obtain good metallurgical results by flotation of complex sulphide ore?
- Author
-
Morizot G., XVI international mineral processing congress Stockholm, Sweden 05-Jun-8810-Jun-88, Croise G., Houot R., Morizot G., XVI international mineral processing congress Stockholm, Sweden 05-Jun-8810-Jun-88, Croise G., and Houot R.
- Abstract
The mineralogical characteristics of Chessy ore seem particularly favourable to a quick and efficient start to implementing a flotation installation which will be able to produce four, even five, different concentrates., The mineralogical characteristics of Chessy ore seem particularly favourable to a quick and efficient start to implementing a flotation installation which will be able to produce four, even five, different concentrates.
- Published
- 1988
22. Preconcentration.
- Author
-
Morizot G., Lafosse J., Morizot G., and Lafosse J.
- Abstract
Preconcentration, which makes it possible to limit intensified size reduction operations and true concentration to a farily small fraction of the ore, is appropriate only if the effective reduction size of the ore is relatively coarse compared with the effective liberation size of the minerals of value and there is a marked difference in physical properties between gangue and minerals of value. Principal methods are: selective comminution followed by classification; gravity separation; magnetic separation; sorting by emission or absorption of radiation. Costs are indicated., Preconcentration, which makes it possible to limit intensified size reduction operations and true concentration to a farily small fraction of the ore, is appropriate only if the effective reduction size of the ore is relatively coarse compared with the effective liberation size of the minerals of value and there is a marked difference in physical properties between gangue and minerals of value. Principal methods are: selective comminution followed by classification; gravity separation; magnetic separation; sorting by emission or absorption of radiation. Costs are indicated.
23. Cobaltiferous tailings treatment for producing a high grade hydroxide.
- Author
-
Ollivier P., Cherif M., Hnid M., Legoas G., Morizot G., Polgaire J.L., Ollivier P., Cherif M., Hnid M., Legoas G., Morizot G., and Polgaire J.L.
24. Upgrading tests of a french phosphate ore from the culm measures by alkaline sintering.
- Author
-
Baudet G., Morizot G., Baudet G., and Morizot G.
25. Shrinkage of roughing and cleaning stage with column flotation. The Chessy case.
- Author
-
Morizot G., Conil P., McKay J., Save M., Morizot G., Conil P., McKay J., and Save M.
- Abstract
A pilot study on copper-zinc ore from the Chessy deposit, near Lyons, France, has shown that one single column could replace a full bank of roughing mechanical cells and two cleaning banks. Zinc concentrate grade is improved by 3% with the same recovery as the mechanical cells and a small increase in copper concentrate quality is also forecast for the industrial operation, which is scheduled to start in mid 1992. A delicate problem will be selectivity between sphalerite and chalcopyrite., A pilot study on copper-zinc ore from the Chessy deposit, near Lyons, France, has shown that one single column could replace a full bank of roughing mechanical cells and two cleaning banks. Zinc concentrate grade is improved by 3% with the same recovery as the mechanical cells and a small increase in copper concentrate quality is also forecast for the industrial operation, which is scheduled to start in mid 1992. A delicate problem will be selectivity between sphalerite and chalcopyrite.
26. New technological developments in mineral processing.
- Author
-
Libaude J., Baudet G., Guillaneau J.C., Morin D., Morizot G., Libaude J., Baudet G., Guillaneau J.C., Morin D., and Morizot G.
- Abstract
The work of BRGM in France in mineral processing research and development over the last ten years is discussed with reference to five different projects. These are: the development of column flotation technology and its application to the Chessy polymetallic ore; the flotation of carbonaceous, sedimentary phosphate ores using a new flotation reagent and a combination of anionic flotation of fine carbonates with cationic flotation of phosphate; the delamination of lamellar minerals by pellet attrition; the bioleaching of refractory gold ore at Salsigne; and the development of the USIMPAC software for modelling a mineral processing plant., The work of BRGM in France in mineral processing research and development over the last ten years is discussed with reference to five different projects. These are: the development of column flotation technology and its application to the Chessy polymetallic ore; the flotation of carbonaceous, sedimentary phosphate ores using a new flotation reagent and a combination of anionic flotation of fine carbonates with cationic flotation of phosphate; the delamination of lamellar minerals by pellet attrition; the bioleaching of refractory gold ore at Salsigne; and the development of the USIMPAC software for modelling a mineral processing plant.
27. Column versus mechanical flotation: application to the Chessy (France) polymetallic project.
- Author
-
Morizot G., Copper 91 Proceedings of the international symposium held in Ottawa, Canada 18-Aug-9121-Aug-91, Conil P., Mangeot M., Save M., Morizot G., Copper 91 Proceedings of the international symposium held in Ottawa, Canada 18-Aug-9121-Aug-91, Conil P., Mangeot M., and Save M.
- Abstract
A systematic comparison between flotation in mechanical cells and that in column cells was carried out at the scale of a pilot plant test on the Cu-Zn ore of Chessy. This study provided the data for an industrial flowsheet using one single column for each of the copper and the zinc circuits in which both roughing and cleaning operations are combined. The economic advantages of this choice are found not only in lower capital investment and operating costs but also in higher revenues. It is estimated that the overall gain will be about US, A systematic comparison between flotation in mechanical cells and that in column cells was carried out at the scale of a pilot plant test on the Cu-Zn ore of Chessy. This study provided the data for an industrial flowsheet using one single column for each of the copper and the zinc circuits in which both roughing and cleaning operations are combined. The economic advantages of this choice are found not only in lower capital investment and operating costs but also in higher revenues. It is estimated that the overall gain will be about US
28. A process for the economic beneficiation of As- and As-Au-bearing antimony ores. Has the dream become a reality?
- Author
-
Morizot G., Ollivier P., Morizot G., and Ollivier P.
- Abstract
Strict European legislation concerning the use of antimony trioxide with traces of arsenic has meant that the antimony mining industry can no longer place concentrates assaying more than 0.1% As on the international market. However, advances in column flotation and bioleaching and the favourable mineralogy of the antimony ores mean that it is possible to meet this challenge and to recover the gold commonly contained in the ore., Strict European legislation concerning the use of antimony trioxide with traces of arsenic has meant that the antimony mining industry can no longer place concentrates assaying more than 0.1% As on the international market. However, advances in column flotation and bioleaching and the favourable mineralogy of the antimony ores mean that it is possible to meet this challenge and to recover the gold commonly contained in the ore.
29. Elimination of the lead contained in a copper concentrate: different possibities of separation by a physical process.
- Author
-
Morizot G., Croise G., Le Calve T., Szczyhel B., Morizot G., Croise G., Le Calve T., and Szczyhel B.
- Abstract
Several methods produced the required results of less than 6% Pb in the copper concentrate and a saleable lead concentrate. These methods included: flotation in hot pulp with or without dextrin; depression of the copper by cyanide; high intensity magnetic separation; and to a certain extent, gravity separation and classification by size range associated with other methods., Several methods produced the required results of less than 6% Pb in the copper concentrate and a saleable lead concentrate. These methods included: flotation in hot pulp with or without dextrin; depression of the copper by cyanide; high intensity magnetic separation; and to a certain extent, gravity separation and classification by size range associated with other methods.
30. Development of the flotation of a polymetallic sulphide ore on a pilot scale: the case of Chessy.
- Author
-
Morizot G., Croise G., Guillaneau J.C., Legret D., Morizot G., Croise G., Guillaneau J.C., and Legret D.
31. Processing of tungsten minerals
- Author
-
Morizot G., Houot R., Save M., Morizot G., Houot R., and Save M.
- Abstract
The physical properties of the main tungsten minerals (scheelite and wolframite) that are used to separate them from the gangue are briefly described followed by a presentation of the methods of beneficiation used for each area of application: preconcentration, concentration and cleaning. Flowsheets illustrate the various industrial scale processes developed for tungsten concentrate production. The integration of ore processing with extractive metallurgy is also discussed., The physical properties of the main tungsten minerals (scheelite and wolframite) that are used to separate them from the gangue are briefly described followed by a presentation of the methods of beneficiation used for each area of application: preconcentration, concentration and cleaning. Flowsheets illustrate the various industrial scale processes developed for tungsten concentrate production. The integration of ore processing with extractive metallurgy is also discussed.
32. Effect of recent technological developments on the beneficiation of French wolframite minerals.
- Author
-
Morizot G., Bajon P.H., Morizot G., and Bajon P.H.
- Abstract
Following a brief survey of French tungsten resources (none currently exploited), various possible methods of beneficiation are reviewed, with details of laboratory and pilot plant tests. The methods involved are photometric sorting, high intensity magnetic separation (wet and dry) and gravity separation using dense media cyclones or Bartles-Mozley tables. Details are also given of a semi-mobile pilot plant developed by the BRGM which can be used to determine the wolframite content of the rather large samples necessitated by the large grain size of the mineral., Following a brief survey of French tungsten resources (none currently exploited), various possible methods of beneficiation are reviewed, with details of laboratory and pilot plant tests. The methods involved are photometric sorting, high intensity magnetic separation (wet and dry) and gravity separation using dense media cyclones or Bartles-Mozley tables. Details are also given of a semi-mobile pilot plant developed by the BRGM which can be used to determine the wolframite content of the rather large samples necessitated by the large grain size of the mineral.
33. Investigation of a process for beneficiating French wolframite minerals.
- Author
-
Save M., Jacquin J.P., Morizot G., Save M., Jacquin J.P., and Morizot G.
- Abstract
The material examined was from a vein deposit at Leucamp (worked from 1916 to 1959) which contains reserves of 350 000 to 500 000 t containing 1.8-2.0% WO3, mainly as wolframite but with some scheelite also. The process developed used a combination of gravity separation methods on different fractions, followed by flotation to remove sulphides and produced a concentrate with 46.3% WO3 from a feed with 1.9% WO3 with 83.7% recovery. Attempts to introduce further stages to improve product quality resulted in a significant fall in recovery., The material examined was from a vein deposit at Leucamp (worked from 1916 to 1959) which contains reserves of 350 000 to 500 000 t containing 1.8-2.0% WO3, mainly as wolframite but with some scheelite also. The process developed used a combination of gravity separation methods on different fractions, followed by flotation to remove sulphides and produced a concentrate with 46.3% WO3 from a feed with 1.9% WO3 with 83.7% recovery. Attempts to introduce further stages to improve product quality resulted in a significant fall in recovery.
34. Travelers With Cutaneous Leishmaniasis Cured Without Systemic Therapy
- Author
-
Morizot, G., Kendjo, E., Mouri, O., Thellier, M., Pérignon, A., Foulet, F., Cordoliani, F., Bourrat, E., Laffitte, E., Alcaraz, I., Bodak, N., Ravel, C., Vray, M., Grogl, M., Mazier, D., Caumes, E., Lachaud, L., Buffet, P. A., El Samad, Y., Salle, V., Gounod, N., Dallot, A., Belot, G., Pelletier-Cunat, S., Belon, M., Verdon, R., Rogeaux, O., Grossetête, G., Lesens, O., Clabaut, A., Maus, E., Jouy, L., Gener, G., Perrin, P., Roch, N., Herve, A., Le Duc, D., Cuchet, E., Maubon, D., Hillion, B., Menot, E., Guillemot, F., Beneton-Benhard, N., Celerier, P., Dupuis De Fonclare, A. L., Carre, D., Bourgeois, A., Marty, P., Pomares, C., Meunier, L., Abergel, H., Timsit, F., Amoric, J. C., Busquet, P., Karam, S., Moisson, Y. F., Mouly, F., Ortoli, J. C., Consigny, P. H., Jouan, M., Caby, F., Datry, A., Hochedez, P., Rozembaum, F., Dumortier, C., Ancelle, T., Dupin, N., Paugam, A., Ranque, B., Bougnoux, M. E., Canestri, A., Galezowsky, M. F., Hadj Rabia, S., Hamel, D., Schneider, P., Wolter-Desfosses, M., Janier, M., Baccard, M., Bezier, M., Broissin, M., Colin De Verdiere, N., Durupt, F., Hope Rapp, E., Juillard, C., Levy, A., Moraillon, I., Petit, A., Regner, S., Barthelme, D., Tamarin, J. M., Begon, E., Strady, C., Gangneux, J. P., Carpentier, O., Mechai, F., Kieffer, C., Dellestable, P., Rebauder, S., Morizot, G., Kendjo, E., Mouri, O., Thellier, M., Pérignon, A., Foulet, F., Cordoliani, F., Bourrat, E., Laffitte, E., Alcaraz, I., Bodak, N., Ravel, C., Vray, M., Grogl, M., Mazier, D., Caumes, E., Lachaud, L., Buffet, P. A., El Samad, Y., Salle, V., Gounod, N., Dallot, A., Belot, G., Pelletier-Cunat, S., Belon, M., Verdon, R., Rogeaux, O., Grossetête, G., Lesens, O., Clabaut, A., Maus, E., Jouy, L., Gener, G., Perrin, P., Roch, N., Herve, A., Le Duc, D., Cuchet, E., Maubon, D., Hillion, B., Menot, E., Guillemot, F., Beneton-Benhard, N., Celerier, P., Dupuis De Fonclare, A. L., Carre, D., Bourgeois, A., Marty, P., Pomares, C., Meunier, L., Abergel, H., Timsit, F., Amoric, J. C., Busquet, P., Karam, S., Moisson, Y. F., Mouly, F., Ortoli, J. C., Consigny, P. H., Jouan, M., Caby, F., Datry, A., Hochedez, P., Rozembaum, F., Dumortier, C., Ancelle, T., Dupin, N., Paugam, A., Ranque, B., Bougnoux, M. E., Canestri, A., Galezowsky, M. F., Hadj Rabia, S., Hamel, D., Schneider, P., Wolter-Desfosses, M., Janier, M., Baccard, M., Bezier, M., Broissin, M., Colin De Verdiere, N., Durupt, F., Hope Rapp, E., Juillard, C., Levy, A., Moraillon, I., Petit, A., Regner, S., Barthelme, D., Tamarin, J. M., Begon, E., Strady, C., Gangneux, J. P., Carpentier, O., Mechai, F., Kieffer, C., Dellestable, P., and Rebauder, S.
- Abstract
Guidelines recommend wound care and/or local therapy as first-line treatment for cutaneous leishmaniasis. An analysis of a referral treatment program in 135 travelers showed that this approach was feasible in 62% of patients, with positive outcome in 83% of evaluable patients
35. Cobaltiferrous tailings treatment for producing a high-grade hydroxide
- Author
-
Ollivier, P., primary, Polgaire, J.L., additional, Cherif, M., additional, Hnid, M., additional, Legoas, G., additional, and Morizot, G., additional
- Published
- 1985
- Full Text
- View/download PDF
36. Fully auto-adaptive microcontroller monitor.
- Author
-
Morizot, G.
- Published
- 1988
- Full Text
- View/download PDF
37. Environnement minier: residus de l'industrie miniere et alternativesde valorisation (in French)
- Author
-
Morizot, G., Lesueur, H., and Zeegers, H.
- Published
- 2000
38. A process for the economic beneficiation of As- and As-Au-bearing antimony ores. Has the dream become a reality?
- Author
-
Morizot, G. and Ollivier, P.
- Published
- 1993
- Full Text
- View/download PDF
39. Environnement minier: residus de l'industrie miniere et alternativesde valorisation
- Author
-
Lesueur, H., Morizot, G., and Zeegers, H.
- Abstract
Waste reprocessing is one way to solve pollution problems related tomining. The purpose of reprocessing, which generally begins with waste collection, is to separate out valuable minerals from highly polluting ones (especially those which generate acid solutions containing concentrations of heavy metals). Reprocessing should not be limited to instances in which it is directly paid for through sales of reprocessed materials. It can also reduce the overall costs of confining wastes and protecting the potentially affected public. These costs are often very high in regions where there has been a significant amount of mining in the past. Any means of reducing the costs of safety measures, or helping pay for them, would therefore be welcome. Public authorities should consider the environmental problems of the industry intheir entirety and support solutions that permit the removal of pollutants from mining wastes and the sale of as much of the remainder aspossible for profit. [ABSTRACT FROM AUTHOR]
- Published
- 1997
40. Liposomal amphotericin B in travelers with cutaneous and muco-cutaneous leishmaniasis: Not a panacea.
- Author
-
Guery R, Henry B, Martin-Blondel G, Rouzaud C, Cordoliani F, Harms G, Gangneux JP, Foulet F, Bourrat E, Baccard M, Morizot G, Consigny PH, Berry A, Blum J, Lortholary O, and Buffet P
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Amphotericin B administration & dosage, Amphotericin B adverse effects, Antiprotozoal Agents administration & dosage, Antiprotozoal Agents adverse effects, Child, Child, Preschool, Female, Humans, Infant, Leishmania classification, Leishmania drug effects, Leishmaniasis, Cutaneous parasitology, Leishmaniasis, Mucocutaneous drug therapy, Leishmaniasis, Mucocutaneous parasitology, Male, Middle Aged, Retrospective Studies, Travel, Treatment Outcome, Amphotericin B therapeutic use, Antiprotozoal Agents therapeutic use, Leishmaniasis, Cutaneous drug therapy
- Abstract
Background: Complex cutaneous and muco-cutaneous leishmaniasis (CL and MCL) often requires systemic therapy. Liposomal amphotericin B (L-AmB) has a strong potential for a solid clinical benefit in this indication., Methods: We conducted a retrospective analysis of data from a French centralized referral treatment program and from the "LeishMan" European consortium database. All patients with parasitologically proven CL or MCL who received at least one dose of L-AmB were included. Positive outcome was based on ulcer closure as per recent WHO workshop guidelines., Results: From 2008 through 2016, 43 travelers returning from 18 countries (Old World n = 28; New World n = 15) were analyzed with a median follow-up duration of 79 days [range 28-803]. Main clinical forms were: localized CL with one or multiple lesions (n = 32; 74%) and MCL (n = 8; 19%). As per published criteria 19 of 41 patients (46%) were cured 90 days after one course of L-AmB. When the following items -improvement before day 90 but no subsequent follow-up, delayed healing (>3 months) and healing after a second course of L-AmB- were included in the definition of cure, 27 of 43 patients (63%) had a positive outcome. Five patients (MCL = 1; CL = 4) experienced a relapse after a median duration of 6 months [range 3-27] post treatment and 53% of patients (23/43) experienced at least one adverse event including severe hypokalaemia and acute cardiac failure (one patient each). In multivariate analysis, tegumentary infection with L. infantum was associated with complete healing after L-AmB therapy (OR 5.8 IC 95% [1.03-32]) while infection with other species had no impact on outcome., Conclusion: In conditions close to current medical practice, the therapeutic window of L-AmB was narrow in travellers with CL or MCL, with the possible exception of those infected with L. infantum. Strict follow-up is warranted when using L-AmB in patients with mild disease.
- Published
- 2017
- Full Text
- View/download PDF
41. Predicting susceptibility to tuberculosis based on gene expression profiling in dendritic cells.
- Author
-
Blischak JD, Tailleux L, Myrthil M, Charlois C, Bergot E, Dinh A, Morizot G, Chény O, Platen CV, Herrmann JL, Brosch R, Barreiro LB, and Gilad Y
- Subjects
- France, Humans, Latent Tuberculosis blood, Latent Tuberculosis microbiology, Male, Mycobacterium tuberculosis physiology, Tuberculosis blood, Tuberculosis microbiology, Dendritic Cells microbiology, Gene Expression Profiling, Genetic Predisposition to Disease genetics, Latent Tuberculosis genetics, Tuberculosis genetics
- Abstract
Tuberculosis (TB) is a deadly infectious disease, which kills millions of people every year. The causative pathogen, Mycobacterium tuberculosis (MTB), is estimated to have infected up to a third of the world's population; however, only approximately 10% of infected healthy individuals progress to active TB. Despite evidence for heritability, it is not currently possible to predict who may develop TB. To explore approaches to classify susceptibility to TB, we infected with MTB dendritic cells (DCs) from putatively resistant individuals diagnosed with latent TB, and from susceptible individuals that had recovered from active TB. We measured gene expression levels in infected and non-infected cells and found hundreds of differentially expressed genes between susceptible and resistant individuals in the non-infected cells. We further found that genetic polymorphisms nearby the differentially expressed genes between susceptible and resistant individuals are more likely to be associated with TB susceptibility in published GWAS data. Lastly, we trained a classifier based on the gene expression levels in the non-infected cells, and demonstrated reasonable performance on our data and an independent data set. Overall, our promising results from this small study suggest that training a classifier on a larger cohort may enable us to accurately predict TB susceptibility.
- Published
- 2017
- Full Text
- View/download PDF
42. Antimony to Cure Visceral Leishmaniasis Unresponsive to Liposomal Amphotericin B.
- Author
-
Morizot G, Jouffroy R, Faye A, Chabert P, Belhouari K, Calin R, Charlier C, Miailhes P, Siriez JY, Mouri O, Yera H, Gilquin J, Tubiana R, Lanternier F, Mamzer MF, Legendre C, Peyramond D, Caumes E, Lortholary O, and Buffet P
- Subjects
- Adult, Aged, Female, Humans, Infant, Male, Middle Aged, Treatment Outcome, Amphotericin B therapeutic use, Antimony therapeutic use, Antiprotozoal Agents therapeutic use, Leishmania donovani drug effects, Leishmaniasis, Visceral drug therapy
- Abstract
We report on 4 patients (1 immunocompetent, 3 immunosuppressed) in whom visceral leishmaniasis had become unresponsive to (or had relapsed after) treatment with appropriate doses of liposomal amphotericin B. Under close follow-up, full courses of pentavalent antimony were administered without life-threatening adverse events and resulted in rapid and sustained clinical and parasitological cure.
- Published
- 2016
- Full Text
- View/download PDF
43. Easy identification of leishmania species by mass spectrometry.
- Author
-
Mouri O, Morizot G, Van der Auwera G, Ravel C, Passet M, Chartrel N, Joly I, Thellier M, Jauréguiberry S, Caumes E, Mazier D, Marinach-Patrice C, and Buffet P
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Female, France, Humans, Leishmania isolation & purification, Male, Middle Aged, Time Factors, Travel, Young Adult, Clinical Laboratory Techniques methods, Leishmania chemistry, Leishmania classification, Leishmaniasis, Cutaneous diagnosis, Leishmaniasis, Cutaneous parasitology, Parasitology methods, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization methods
- Abstract
Background: Cutaneous leishmaniasis is caused by several Leishmania species that are associated with variable outcomes before and after therapy. Optimal treatment decision is based on an accurate identification of the infecting species but current methods to type Leishmania isolates are relatively complex and/or slow. Therefore, the initial treatment decision is generally presumptive, the infecting species being suspected on epidemiological and clinical grounds. A simple method to type cultured isolates would facilitate disease management., Methodology: We analyzed MALDI-TOF spectra of promastigote pellets from 46 strains cultured in monophasic medium, including 20 short-term cultured isolates from French travelers (19 with CL, 1 with VL). As per routine procedure, clinical isolates were analyzed in parallel with Multilocus Sequence Typing (MLST) at the National Reference Center for Leishmania., Principal Findings: Automatic dendrogram analysis generated a classification of isolates consistent with reference determination of species based on MLST or hsp70 sequencing. A minute analysis of spectra based on a very simple, database-independent analysis of spectra based on the algorithm showed that the mutually exclusive presence of two pairs of peaks discriminated isolates considered by reference methods to belong either to the Viannia or Leishmania subgenus, and that within each subgenus presence or absence of a few peaks allowed discrimination to species complexes level., Conclusions/significance: Analysis of cultured Leishmania isolates using mass spectrometry allows a rapid and simple classification to the species complex level consistent with reference methods, a potentially useful method to guide treatment decision in patients with cutaneous leishmaniasis.
- Published
- 2014
- Full Text
- View/download PDF
44. Parasite load decrease during application of a safe and easily applied antileishmanial aminoglycoside cream.
- Author
-
Ben Salah A, Zaâtour A, Ben Messaoud N, Kidar A, Smith PL, Kopydlowski KM, Kreishman-Deitrick M, Nielsen CJ, Novitt-Moreno A, Ransom JH, Morizot G, Grogl M, and Buffet PA
- Subjects
- Administration, Topical, Adolescent, Adult, Aged, Dermis parasitology, Drug Combinations, Female, Humans, Male, Middle Aged, Parasite Load, Trypanocidal Agents adverse effects, Young Adult, Gentamicins administration & dosage, Leishmania donovani drug effects, Leishmaniasis, Visceral drug therapy, Leishmaniasis, Visceral parasitology, Paromomycin administration & dosage, Trypanocidal Agents administration & dosage
- Published
- 2014
- Full Text
- View/download PDF
45. LeishMan recommendations for treatment of cutaneous and mucosal leishmaniasis in travelers, 2014.
- Author
-
Blum J, Buffet P, Visser L, Harms G, Bailey MS, Caumes E, Clerinx J, van Thiel PP, Morizot G, Hatz C, Dorlo TP, and Lockwood DN
- Subjects
- Disease Outbreaks prevention & control, Global Health, Humans, Leishmaniasis, Cutaneous ethnology, Leishmaniasis, Mucocutaneous drug therapy, Leishmaniasis, Mucocutaneous ethnology, Antiprotozoal Agents therapeutic use, Leishmaniasis, Cutaneous drug therapy, Practice Guidelines as Topic, Travel
- Abstract
Background: Treatment of cutaneous leishmaniasis (CL) and mucosal leishmaniasis (ML) in travelers is still controversial. Over the last decade, national and international consortia have published recommendations for treating CL in travelers. These guidelines harmonize many issues, but there are some discrepancies., Methods: Leishmania parasites causing CL can now be genotyped by polymerase chain reaction techniques for detecting Leishmania DNA. Therefore, treatment recommendations can now be species based rather than based on geographical exposure. To review the evidence on which the recommendations were based, "LeishMan" (Leishmaniasis Management), a group of experts from 13 institutions in eight European countries, performed a PubMed MEDLINE) literature search and considered unpublished evidence and the experts' own personal experiences. The Oxford evidence grading system was used to evaluate the information., Results and Conclusion: In this article, the authors provide practical treatment recommendations for imported CL and ML in Europe, drawn up from the review by the European experts.
- Published
- 2014
- Full Text
- View/download PDF
46. Clinical aspects and management of cutaneous leishmaniasis in rheumatoid patients treated with TNF-α antagonists.
- Author
-
Neumayr AL, Morizot G, Visser LG, Lockwood DN, Beck BR, Schneider S, Bellaud G, Cordoliani F, Foulet F, Laffitte EA, Buffet P, and Blum JA
- Subjects
- Adult, Arthritis, Rheumatoid drug therapy, Female, Humans, Leishmaniasis, Cutaneous complications, Male, Middle Aged, Anti-Inflammatory Agents therapeutic use, Antiprotozoal Agents therapeutic use, Arthritis, Rheumatoid parasitology, Leishmaniasis, Cutaneous drug therapy, Tumor Necrosis Factor-alpha antagonists & inhibitors
- Abstract
Patients under immunosuppressive therapy with tumor necrosis factor alpha (TNF-α) antagonists are vulnerable to various opportunistic infections including leishmaniasis. We present a case series of 8 travellers developing cutaneous leishmaniasis whilst on TNF-α antagonist treatment and review the literature on aspects of cutaneous leishmaniasis developing in patients treated with TNF-α antagonists. We make interim recommendations regarding the drug therapy used to maintain remission in travellers with rheumatoid disease travelling to leishmania prone areas. Despite having a medical condition requiring continued rheumatological review the interval to diagnosis appears not to be reduced compared to that described in non-rheumatoid patients. Rheumatologists and family doctors should be aware of the need for post-travel surveillance for leishmaniasis in rheumatoid patients on TNF-alpha antagonist treatment., (Copyright © 2013. Published by Elsevier Ltd.)
- Published
- 2013
- Full Text
- View/download PDF
47. Topical paromomycin with or without gentamicin for cutaneous leishmaniasis.
- Author
-
Ben Salah A, Ben Messaoud N, Guedri E, Zaatour A, Ben Alaya N, Bettaieb J, Gharbi A, Belhadj Hamida N, Boukthir A, Chlif S, Abdelhamid K, El Ahmadi Z, Louzir H, Mokni M, Morizot G, Buffet P, Smith PL, Kopydlowski KM, Kreishman-Deitrick M, Smith KS, Nielsen CJ, Ullman DR, Norwood JA, Thorne GD, McCarthy WF, Adams RC, Rice RM, Tang D, Berman J, Ransom J, Magill AJ, and Grogl M
- Subjects
- Administration, Topical, Adolescent, Adult, Aged, Child, Child, Preschool, Drug Therapy, Combination, Female, Gentamicins adverse effects, Humans, Intention to Treat Analysis, Male, Middle Aged, Ointments, Paromomycin adverse effects, Young Adult, Gentamicins administration & dosage, Leishmaniasis, Cutaneous drug therapy, Paromomycin administration & dosage
- Abstract
Background: There is a need for a simple and efficacious treatment for cutaneous leishmaniasis with an acceptable side-effect profile., Methods: We conducted a randomized, vehicle-controlled phase 3 trial of topical treatments containing 15% paromomycin, with and without 0.5% gentamicin, for cutaneous leishmaniasis caused by Leishmania major in Tunisia. We randomly assigned 375 patients with one to five ulcerative lesions from cutaneous leishmaniasis to receive a cream containing 15% paromomycin-0.5% gentamicin (called WR 279,396), 15% paromomycin alone, or vehicle control (with the same base as the other two creams but containing neither paromomycin nor gentamicin). Each lesion was treated once daily for 20 days. The primary end point was the cure of the index lesion. Cure was defined as at least 50% reduction in the size of the index lesion by 42 days, complete reepithelialization by 98 days, and absence of relapse by the end of the trial (168 days). Any withdrawal from the trial was considered a treatment failure., Results: The rate of cure of the index lesion was 81% (95% confidence interval [CI], 73 to 87) for paromomycin-gentamicin, 82% (95% CI, 74 to 87) for paromomycin alone, and 58% (95% CI, 50 to 67) for vehicle control (P<0.001 for each treatment group vs. the vehicle-control group). Cure of the index lesion was accompanied by cure of all other lesions except in five patients, one in each of the paromomycin groups and three in the vehicle-control group. Mild-to-moderate application-site reactions were more frequent in the paromomycin groups than in the vehicle-control group., Conclusions: This trial provides evidence of the efficacy of paromomycin-gentamicin and paromomycin alone for ulcerative L. major disease. (Funded by the Department of the Army; ClinicalTrials.gov number, NCT00606580.).
- Published
- 2013
- Full Text
- View/download PDF
48. Local or systemic treatment for New World cutaneous leishmaniasis? Re-evaluating the evidence for the risk of mucosal leishmaniasis.
- Author
-
Blum J, Lockwood DN, Visser L, Harms G, Bailey MS, Caumes E, Clerinx J, van Thiel PP, Morizot G, Hatz C, and Buffet P
- Abstract
This review addresses the question of whether the risk of developing mucosal leishmaniasis (ML) warrants systemic treatment in all patients with New World cutaneous leishmaniasis (CL) or whether local treatment might be an acceptable alternative. The risk of patients with New World CL developing ML after the initial infection has been the main argument for systemic treatment. However, this statement needs re-evaluation and consideration of all the available data. The putative benefit of preventing ML should outweigh the toxicity of systemic antileishmanial therapy. To assess the need for and risk of systemic treatment the following factors were reviewed: the incidence and prevalence of ML in endemic populations and in travellers; the severity of mucosal lesions; the efficacy of current options to treat ML; the toxicity and, to a lesser extent, the costs of systemic treatment; the risk of developing ML after local treatment; and the strengths and limitations of current estimates of the risk of developing ML in different situations. Local treatment might be considered as a valuable treatment option for travellers suffering from New World CL, provided that there are no risk factors for developing ML such as multiple lesions, big lesions (>4 cm(2)), localisation of the lesion on the head or neck, immunosuppression or acquisition of infection in the high Andean countries, notably Bolivia.
- Published
- 2012
- Full Text
- View/download PDF
49. [Therapy of leishmaniasis in France: consensus on proposed guidelines].
- Author
-
Buffet PA, Rosenthal É, Gangneux JP, Lightburne E, Couppié P, Morizot G, Lachaud L, Marty P, and Dedet JP
- Subjects
- France, Humans, Leishmaniasis, Cutaneous drug therapy, Leishmaniasis, Visceral drug therapy, Leishmaniasis drug therapy
- Abstract
Because it relies on potentially toxic, difficult-to-handle, or expensive compounds the therapy of leishmaniasis is still a complex issue in 2010, especially for visceral leishmaniasis in immuno-suppressed subjects, or in patients with cutaneous and mucosal involvement. This induces a wide diversity of observed therapeutic practices, some being sub-optimal. The Société de Pathologie Exotique organised a meeting dedicated to the therapy of leishmaniasis in France that led to the first consensus on therapeutic guidelines. Liposomal amphotericin B is the first-line option for visceral leishmaniasis both in immunocompetent, and immunosuppressed patients (cumulated doses of 20 mg/kg and 30-40 mg/kg, respectively). Secondary prophylaxis with either liposomal amphotericin B, pentamidine or meglumine antimoniate is proposed to patients with heavy immunosuppression until immunity has been restored for at least 6 months. While the efficacy of new topical formulations of paromomycin is being tested, patients with Old World cutaneous leishmaniasis may be left untreated, or be administered a combination of superficial cryotherapy plus intralesional antimony, or even--in complex situations--receive systemic therapy. The efficacy of a short course of pentamidine (L. guyanensis/L. panamensis) and a 20-day schedule of meglumine antimoniate (L. braziliensis) is solidly established. However, in well-defined situations, local therapy of New World cutaneous leishmaniasis is now considered acceptable., (Copyright © 2010 Elsevier Masson SAS. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
50. WR279,396, a third generation aminoglycoside ointment for the treatment of Leishmania major cutaneous leishmaniasis: a phase 2, randomized, double blind, placebo controlled study.
- Author
-
Ben Salah A, Buffet PA, Morizot G, Ben Massoud N, Zâatour A, Ben Alaya N, Haj Hamida NB, El Ahmadi Z, Downs MT, Smith PL, Dellagi K, and Grögl M
- Subjects
- Adolescent, Adult, Aged, Aminoglycosides pharmacology, Child, Child, Preschool, Double-Blind Method, France, Gentamicins therapeutic use, Humans, Leishmania major drug effects, Leishmaniasis, Cutaneous parasitology, Middle Aged, Paromomycin therapeutic use, Placebos, Treatment Outcome, Trypanocidal Agents pharmacology, Tunisia, Young Adult, Aminoglycosides therapeutic use, Leishmania major physiology, Leishmaniasis, Cutaneous drug therapy, Ointments therapeutic use, Trypanocidal Agents therapeutic use
- Abstract
Background: Cutaneous leishmaniasis (cl) is a disfiguring disease that confronts clinicians with a quandary: leave patients untreated or engage in a complex or toxic treatment. Topical treatment of CL offers a practical and safe option. Accordingly, the treatment of CL with WR279,396, a formulation of paromomycin and gentamicin in a hydrophilic base, was investigated in a phase 2 clinical study in Tunisia and France., Methods: A phase 2, randomized, double blind, vehicle-controlled study was conducted to assess the safety and efficacy of topical WR279,396 when applied twice a day for 20 days as treatment for parasitologically confirmed CL. The study protocol established the primary efficacy end point as complete clinical response (CCR) defined as 50% or greater reduction in the ulceration size of an index lesion by day 50 (D50) followed by complete re-epithelialization by D100, and no relapse through D180., Results: Ninety-two subjects were randomized. Leishmania major was identified in 66 of 68 isolates typed (97%). In the intent-to-treat population, 47 of 50 WR279,396 treated participants (94%) met the definition of CCR, compared with 30 of 42 vehicle-placebo participants (71%) [p = 0.0045]. Erythema occurred in 30% and 24% of participants receiving WR279,396 and placebo, respectively [p = 0.64]. There was no clinical or laboratory evidence of systemic toxicity., Conclusion: Application of WR279,396 for 20 days was found to be safe and effective in treating L. major CL, and offers great potential as a new, simple, easily applicable, and inexpensive topical therapy for this neglected disease., Trial Registration: ClinicalTrials.gov NCT00703924.
- Published
- 2009
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.