Search

Your search keyword '"Moriwake, Tadashi"' showing total 33 results
Start Over Author "Moriwake, Tadashi"
33 results on '"Moriwake, Tadashi"'

2. Radiological characteristics of skeletal growth in neonates and infants with achondroplasia.

Author

Miyahara, Daisuke, Hasegawa, Kosei, Ago, Yuko, Futagawa, Natsuko, Miyahara, Hiroyuki, Higuchi, Yousuke, Yamada, Kazuki, Tetsunaga, Tomonori, Moriwake, Tadashi, Tanaka, Hiroyuki, and Tsukahara, Hirokazu more...

Abstract

Achondroplasia (ACH) is the most common form of skeletal dysplasia characterized by a rhizomelic short stature. Radiological skeletal findings in pediatric and adult patients with ACH include short long bones, a relatively longer fibula compared to the tibia, a narrow lumbar interpedicular distance, and a hypoplastic iliac wing. Nonetheless, the characteristics of skeletal growth during the neonatal and infantile periods have scarcely been explored. Therefore, this retrospective study aimed to analyze the radiological skeletal growth during the neonatal and infantile periods in 41 Japanese patients with genetically confirmed ACH. The length of long bones in the upper and lower limbs and the lumbar interpedicular distances at L1 and L4 were measured. These parameters showed significant positive correlations with age. The upper segment‐to‐lower segment ratio in the lower limbs resembled the data of healthy controls from previous reports. The L1/L4 and fibula/tibia ratios increased with age, suggesting that some representative skeletal phenotypes of ACH were less distinct during the neonatal and infantile periods. In conclusion, for the first time, this study radiologically characterized skeletal growth during the neonatal and infantile periods of patients with genetically confirmed ACH. [ABSTRACT FROM AUTHOR] more...

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results

3. Coronary artery lesions and the increasing incidence of Kawasaki disease resistant to initial immunoglobulin

Author

Kibata, Tetsuhiro, Suzuki, Yasuo, Hasegawa, Shunji, Matsushige, Takeshi, Kusuda, Takeshi, Hoshide, Madoka, Takahashi, Kazumasa, Okada, Seigo, Wakiguchi, Hiroyuki, Moriwake, Tadashi, Uchida, Masashi, Ohbuchi, Noriko, Iwai, Takashi, Hasegawa, Masanari, Ichihara, Kiyoshi, Yashiro, Mayumi, Makino, Nobuko, Nakamura, Yosikazu, and Ohga, Shouichi more...

Published
2016
Full Text
View/download PDF

4. Novel and recurrent COMP gene variants in five Japanese patients with pseudoachondroplasia: skeletal changes from the neonatal to infantile periods

Author

Hasegawa, Kosei, Futagawa, Natsuko, Ago, Yuko, Miyahara, Hiroyuki, Harada, Daisuke, Miyazawa, Mari, Yoshimoto, Junko, Baba, Kenji, Moriwake, Tadashi, Tanaka, Hiroyuki, Tsukahara, Hirokazu, Hasegawa, Kosei, Futagawa, Natsuko, Ago, Yuko, Miyahara, Hiroyuki, Harada, Daisuke, Miyazawa, Mari, Yoshimoto, Junko, Baba, Kenji, Moriwake, Tadashi, Tanaka, Hiroyuki, and Tsukahara, Hirokazu more...

Abstract

Pseudoachondroplasia (PSACH) is an autosomal dominant skeletal dysplasia caused by pathogenic variants of cartilage oligomeric matrix protein (COMP). Clinical symptoms of PSACH are characterized by growth disturbances after the first year of life. These disturbances lead to severe short stature with short limbs, brachydactyly, scoliosis, joint laxity, joint pain since childhood, and a normal face. Epimetaphyseal dysplasia, shortened long bones, and short metacarpals and phalanges are common findings on radiological examination. Additionally, anterior tonguing of the vertebral bodies in the lateral view is an important finding in childhood because it is specific to PSACH and normalizes with age. Here, we report five Japanese patients with PSACH, with one recurrent (p.Cys351Tyr) and four novel heterozygous pathogenic COMP variants (p.Asp437Tyr, p.Asp446Gly, p.Asp507Tyr, and p.Asp518Val). These five pathogenic variants were located in the calcium-binding type 3 (T3) repeats. In four of the novel variants, the affected amino acid was aspartic acid, which is abundant in each of the eight T3 repeats. We describe the radiological findings of these five patients. We also retrospectively analyzed the sequential changes in the vertebral body and epimetaphysis of the long bones from the neonatal to infantile periods in a patient with PSACH and congenital heart disease. more...

Published
2023

5. Novel and recurrent COMP gene variants in five Japanese patients with pseudoachondroplasia: skeletal changes from the neonatal to infantile periods

Author

Hasegawa, Kosei, primary, Futagawa, Natsuko, additional, Ago, Yuko, additional, Miyahara, Hiroyuki, additional, Harada, Daisuke, additional, Miyazawa, Mari, additional, Yoshimoto, Junko, additional, Baba, Kenji, additional, Moriwake, Tadashi, additional, Tanaka, Hiroyuki, additional, and Tsukahara, Hirokazu, additional more...

Published
2023
Full Text
View/download PDF

7. A pediatric case of ureterolithiasis due to cystinuria accompanied by acute appendicitis; a case report

Author

Hiraoka, Tomohiro, Kawamura, Mai, Takada, Keisuke, Moriwake, Tadashi, Hiraoka, Tomohiro, Kawamura, Mai, Takada, Keisuke, and Moriwake, Tadashi

Abstract

Introduction: Acute abdominal pain, a chief complaint frequently seen in the emergency department, can be triggered by a vast range of conditions. Although ureterolithiasis is a less common cause in children, renal colic can be caused by calculi due to hereditary metabolic diseases among patients in those age groups. Presentation of case: We report a 12-year-old girl with abdominal pain who was diagnosed with concurrent acute appendicitis and ureterolithiasis due to cystinuria. Acute appendicitis was successfully treated with cefmetazole, and the calculus was eliminated after adequate fluid loading. Discussion: Synchronous acute appendicitis and ureterolithiasis is reported to be rare. Cystinuria is a hereditary metabolic stone-forming disease, and the first calculi can be detected in childhood. Increasing the solubility of cystine in the urine is required to prevent recurrent stone formation and accompanying complications. Urinalysis, ultrasound, and computed tomography coincidentally demonstrated two different acute pathological processes of ureterolithiasis and appendicitis. Conclusion: Careful physical and laboratory examination can help clinicians find coexisting etiologies of acute abdominal pain. Ureterolithiasis can be seen in children with hereditary disorders such as cystinuria. Early diagnosis of cystinuria and close monitoring may lead to a better long-term outcome. more...

Published
2022

20. Growth Hormone Therapy in Achondroplasia

Author

Seino, Yoshiki, primary, Yamanaka, Yoshitaka, additional, Shinohara, Mayu, additional, Ikegami, Saeko, additional, Koike, Mio, additional, Miyazawa, Mari, additional, Inoue, Masaru, additional, Moriwake, Tadashi, additional, and Tanaka, Hiroyuki, additional more...

Published
2000
Full Text
View/download PDF

25. Effects of GH Therapy on Bone Mass in Childhood

Author

Sato, Masayoshi, primary, Moriwake, Tadashi, additional, Tanaka, Hiroyuki, additional, Ono, Taeko, additional, Tokumaru, Hisashi, additional, Tobiume, Hitoshi, additional, Inoue, Masaru, additional, Kanzaki, Susumu, additional, and Seino, Yoshiki, additional more...

Published
1997
Full Text
View/download PDF

30. The Clinical Usefulness of Liquid Human Growth Hormone (hGH) (Norditropin[sup ®] SimpleXx[sup TM] ) in the Treatment of GH Deficiency.

Author

Iyoda, Kuniaki, Moriwake, Tadashi, Seino, Yoshiki, and Niimi, Hiroo

Subjects
*SOMATOTROPIN, *PITUITARY hormones, *THERAPEUTICS, *LEGAL compliance
Abstract

Human growth hormone (hGH) is an essential therapeutic drug for the treatment of GH deficiency. The development of recombinant GH using a pen injection system has enabled easy and safe treatment of GH-deficient patients; however, the process of dissolving hGH in the powder form is complicated and dangerous. In this study, we investigated the usefulness of a newly developed liquid form of hGH (Norditropin[sup ®] SimpleXx[sup TM] ) in the treatment of 51 patients with GH deficiency. Fifteen previously untreated patients with GH deficiency were treated with liquid hGH (group A), and 36 patients who had previously used hGH in the powder form were changed to the liquid form (group B). Both groups were treated with liquid hGH 0.5 IU/kg per week for 6 months. The growth rate of patients in group A increased from 4.0 ± 2.4 cm/year to 9.2 ± 2.9 cm/year. The patients in group B continued to grow at the same rate as before using the liquid hGH therapy. Questionnaires to the patients in group B demonstrated that 85% preferred the convenience of using the new liquid form of hGH. Our results indicate that liquid hGH has similar efficacy to that of powder hGH, but its improved convenience may have a beneficial effect on patient compliance.Copyright © 1999 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] more...

Published
1999
Full Text
View/download PDF

31. Seasonal level of hemoagglutinin inhibiting antibody and its 2-mercaptoethanol sensitive antibody in the sera of animals, inhabitants and patients; Comparison of results in 1968 with those in 1965-1967

Author

Ogata, Masana, primary, Nagao, Yutaka, additional, Tomokuni, Katsumaro, additional, Teratani, Iwao, additional, Hitomi, Katashi, additional, Takatsuka, Yoshiko, additional, Nishioka, Keiko, additional, Yasui, Shigeo, additional, Kinami, Tomikichi, additional, Kumashiro, Kazuo, additional, Hongo, Hiroshi, additional, Okuma, Katsuaki, additional, Moriwake, Tadashi, additional, Okuma, Yoshifumi, additional, Kakizaki, Toshio, additional, Seto, Takashi, additional, Takagoshi, Yoshiaki, additional, Sumida, Shozo, additional, Sunami, Shigeo, additional, Jitsunari, Fumihiko, additional, Yunoki, Hideji, additional, Miyake, Yoshio, additional, Sugi, Sakuzo, additional, Kajikiyo, Teturo, additional, Akagi, Masayasu, additional, Inoue, Kentaro, additional, Tabuchi, Eiko, additional, Meguro, Tadamichi, additional, Inoue, Toyoko, additional, Asakawa, Fumiyuki, additional, Takaya, Yoichi, additional, Shigeta, Ayamichi, additional, Hasegawa, Tomoko, additional, Kitamura, Naoji, additional, Kikui, Ritsuko, additional, Ikumoto, Teruko, additional, Kanno, Shoichiro, additional, Otokura, Takashi, additional, Okazaki, Tokio, additional, Inoue, Yoshinobu, additional, Morishita, Takashi, additional, and Shimomura, Kaoru, additional more...

Published
1969
Full Text
View/download PDF

33. Pediatric Severe Febrile Thrombocytopenia Syndrome: A Case Report and Literature Review.

Author

Toyota Y, Uda K, Shirabe K, and Moriwake T

Subjects
Humans, Female, Child, Thrombocytopenia diagnosis, Severe Fever with Thrombocytopenia Syndrome diagnosis
Abstract

Severe febrile thrombocytopenia syndrome (SFTS) is a tick-borne infectious disease that is endemic in parts of eastern Asia. Few pediatric cases have been reported. We describe a case of SFTS in a seven-year-old girl who presented with prolonged fever and gastrointestinal symptoms. Leukopenia and thrombocytopenia on hematology, and a history of outdoor activity led us to diagnose SFTS, although the patient had no tick bite marks. We also review the literature and discuss the characteristics of pediatric SFTS. Physicians should consider SFTS in the differential diagnosis of fever with thrombocytopenia in children living in endemic areas., Competing Interests: No potential conflict of interest relevant to this article was reported. more...

Published
2024
Full Text
View/download PDF