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4. Repeating

Author

Moritz-Gasser, Sylvie, Mandonnet, Emmanuel, editor, and Herbet, Guillaume, editor

Published
2021
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5. Lexical Retrieval

Author

Moritz-Gasser, Sylvie, Herbet, Guillaume, Mandonnet, Emmanuel, editor, and Herbet, Guillaume, editor

Published
2021
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8. Multivariate mapping of low-resilient neurocognitive systems within and around low-grade gliomas.

Author

Ng, Sam, Moritz-Gasser, Sylvie, Lemaitre, Anne-Laure, Duffau, Hugues, and Herbet, Guillaume

Subjects
*BRAIN tumors, *FRONTAL lobe, *TEMPORAL lobe, *CORPUS callosum, *CINGULATE cortex, *VERBAL behavior testing
Abstract

Accumulating evidence suggests that the brain exhibits a remarkable capacity for functional compensation in response to neurological damage, a resilience potential that is deeply rooted in the malleable features of its underlying anatomofunctional architecture. This propensity is particularly exemplified by diffuse low-grade glioma, a subtype of primary brain tumour. However, functional plasticity is not boundless, and surgical resections directed at structures with limited neuroplasticity can lead to incapacitating impairments. Yet, maximizing diffuse low-grade glioma resections offers substantial oncological benefits, especially when the resection extends beyond the tumour margins (i.e. supra-tumour or supratotal resection). In this context, the primary objective of this study was to identify which cerebral structures were associated with less favourable cognitive outcomes after surgery, while accounting for intra-tumour and supra-tumour features of the surgical resections. To achieve this objective, we leveraged a unique cohort of 400 patients with diffuse low-grade glioma who underwent surgery with awake cognitive mapping. Patients benefitted from a neuropsychological assessment consisting of 18 subtests administered before and 3 months after surgery. We analysed changes in performance and applied topography-focused and disconnection-focused multivariate lesion–symptom mapping using support vector regressions, in an attempt to capture resected cortico-subcortical structures less amenable to full cognitive compensation. The observed changes in performance were of a limited magnitude, suggesting an overall recovery (13 of 18 tasks recovered fully despite a mean resection extent of 92.4%). Nevertheless, lesion–symptom mapping analyses revealed that a lack of recovery in picture naming was linked to damage in the left inferior temporal gyrus and inferior longitudinal fasciculus. Likewise, for semantic fluency abilities, an association was established with damage to the left precuneus/posterior cingulate. For phonological fluency abilities, the left dorsomedial frontal cortex and the frontal aslant tract were implicated. Moreover, difficulties in spatial exploration were associated with injury to the right dorsomedial prefrontal cortex and its underlying connectivity. An exploratory analysis suggested that supra-tumour resections were associated with a less pronounced recovery following specific resection patterns, such as supra-tumour resections of the left uncinate fasciculus (picture naming), the left corticostriatal tract and the anterior corpus callosum (phonological fluency), the hippocampus and parahippocampus (episodic memory) and the right frontal–mesial areas (visuospatial exploration). Collectively, these patterns of results shed new light on both low-resilient neural systems and the prediction of cognitive recovery following glioma surgery. Furthermore, they indicate that supra-tumour resections were only occasionally less well tolerated from a cognitive viewpoint. In doing so, they have deep implications for surgical planning and rehabilitation strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Disruption of the left anterior ventrolateral temporal cortex along with the inferior longitudinal fasciculus impairs the ability to retrieve famous face names: Evidence from three longitudinal case studies.

Author

Burkhardt, Eléonor, Lemaitre, Anne‐Laure, Ng, Sam, Moritz‐Gasser, Sylvie, Hirsch, Fabrice, Duffau, Hugues, and Herbet, Guillaume

Subjects
TEMPORAL lobe, LONGITUDINAL method, GLIOMAS, FUSIFORM gyrus, ANATOMY
Abstract

The cortical distribution of the proper name (PN) retrieval network has been widely studied contrary to its connectional anatomy. Here, we report the case of three patients with a low‐grade glioma damaging the mid‐to‐anterior part of the left temporal lobe. A longitudinal behavioural assessment showed that the surgery caused a long‐lasting decline in PN retrieval performances in all patients. Furthermore, a detailed analysis of surgery‐related structural disconnections revealed that interruption of the inferior longitudinal fasciculus was the unique common denominator. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Survey on current cognitive practices within the European Low-Grade Glioma Network: towards a European assessment protocol

Author

Rofes, Adrià, Mandonnet, Emmanuel, Godden, John, Baron, Marie Hélène, Colle, Henry, Darlix, Amelie, de Aguiar, Vânia, Duffau, Hugues, Herbet, Guillaume, Klein, Martin, Lubrano, Vincent, Martino, Juan, Mathew, Ryan, Miceli, Gabriele, Moritz-Gasser, Sylvie, Pallud, Johan, Papagno, Costanza, Rech, Fabien, Robert, Erik, Rutten, Geert-Jan, Santarius, Thomas, Satoer, Djaina, Sierpowska, Joanna, Smits, Anja, Skrap, Miran, Spena, Giannantonio, Visch, Evy, De Witte, Elke, Zetterling, Maria, and Wager, Michel

Published
2017
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