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261 results on '"Morita, Yohei"'

6. Twenty‐Four‐Hour Blood Pressure‐Lowering Efficacy of Sacubitril/Valsartan Versus Olmesartan in Japanese Patients With Essential Hypertension Based on Nocturnal Blood Pressure Dipping Status: A Post Hoc Analysis of Data From a Randomized, Double‐Blind Multicenter Study

Author

Kario, Kazuomi, primary, Rakugi, Hiromi, additional, Yarimizu, Daisuke, additional, Morita, Yohei, additional, Eguchi, Shunsuke, additional, and Iekushi, Kazuma, additional

Published
2023
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7. Supplementary Figure 3 from The Polycomb Gene Product BMI1 Contributes to the Maintenance of Tumor-Initiating Side Population Cells in Hepatocellular Carcinoma

Author

Chiba, Tetsuhiro, primary, Miyagi, Satoru, primary, Saraya, Atsunori, primary, Aoki, Ryutaro, primary, Seki, Atsuyoshi, primary, Morita, Yohei, primary, Yonemitsu, Yutaka, primary, Yokosuka, Osamu, primary, Taniguchi, Hideki, primary, Nakauchi, Hiromitsu, primary, and Iwama, Atsushi, primary

Published
2023
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8. Supplementary Figure 2 from The Polycomb Gene Product BMI1 Contributes to the Maintenance of Tumor-Initiating Side Population Cells in Hepatocellular Carcinoma

Author

Chiba, Tetsuhiro, primary, Miyagi, Satoru, primary, Saraya, Atsunori, primary, Aoki, Ryutaro, primary, Seki, Atsuyoshi, primary, Morita, Yohei, primary, Yonemitsu, Yutaka, primary, Yokosuka, Osamu, primary, Taniguchi, Hideki, primary, Nakauchi, Hiromitsu, primary, and Iwama, Atsushi, primary

Published
2023
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9. Supplementary Figure Legends 1-3 from The Polycomb Gene Product BMI1 Contributes to the Maintenance of Tumor-Initiating Side Population Cells in Hepatocellular Carcinoma

Author

Chiba, Tetsuhiro, primary, Miyagi, Satoru, primary, Saraya, Atsunori, primary, Aoki, Ryutaro, primary, Seki, Atsuyoshi, primary, Morita, Yohei, primary, Yonemitsu, Yutaka, primary, Yokosuka, Osamu, primary, Taniguchi, Hideki, primary, Nakauchi, Hiromitsu, primary, and Iwama, Atsushi, primary

Published
2023
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11. Supplementary Figure 1 from The Polycomb Gene Product BMI1 Contributes to the Maintenance of Tumor-Initiating Side Population Cells in Hepatocellular Carcinoma

Author

Chiba, Tetsuhiro, primary, Miyagi, Satoru, primary, Saraya, Atsunori, primary, Aoki, Ryutaro, primary, Seki, Atsuyoshi, primary, Morita, Yohei, primary, Yonemitsu, Yutaka, primary, Yokosuka, Osamu, primary, Taniguchi, Hideki, primary, Nakauchi, Hiromitsu, primary, and Iwama, Atsushi, primary

Published
2023
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24. The peripheral differentiation of human natural killer T cells

Author

Liu, Jie, Hill, Brenna J, Darko, Sam, Song, Kaimei, Quigley, Máire F, Asher, Tedi E, Morita, Yohei, Greenaway, Hui Y, Venturi, Vanessa, Douek, Daniel C, Davenport, Miles P, Price, David A, and Roederer, Mario

Subjects
Receptors, CCR5, CD8 Antigens, Receptors, Antigen, T-Cell, High-Throughput Nucleotide Sequencing, hemic and immune systems, chemical and pharmacologic phenomena, Cell Differentiation, Original Articles, Flow Cytometry, Lymphocyte Subsets, Clone Cells, Immunophenotyping, T‐cell differentiation, CD4 Antigens, Cytokines, Humans, Natural Killer T-Cells, Original Article, Antigens, CD1d, NKT cell, TREC, TCR, Cells, Cultured
Abstract

The peripheral maturation of human CD1d‐restricted natural killer T (NKT) cells has not been well described. In this study, we identified four major subsets of NKT cells in adults, distinguished by the expression of CD4, CD8 and CCR5. Phenotypic analysis suggested a hierarchical pattern of differentiation, whereby immature CD4+ CD8− CCR5− cells progressed to an intermediate CD4+ CD8− CCR5+ stage, which remained less differentiated than the CD4− CD8− and CD4− CD8+ subsets, both of which expressed CCR5. This interpretation was supported by functional data, including clonogenic potential and cytokine secretion profiles, as well as T‐cell receptor (TCR) excision circle analysis. Moreover, conventional and high‐throughput sequencing of the corresponding TCR repertoires demonstrated significant clonotypic overlap within individuals, especially between the more differentiated CD4− CD8− and CD4− CD8+ subsets. Collectively, these results mapped a linear differentiation pathway across the post‐thymic landscape of human CD1d‐restricted NKT cells.

Published
2019

29. Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo

Author

Takizawa, Hitoshi, Nishimura, Satoshi, Takayama, Naoya, Oda, Atsushi, Nishikii, Hidekazu, Morita, Yohei, Kakinuma, Sei, Yamazaki, Satoshi, Okamura, Satoshi, Tamura, Noriko, Goto, Shinya, Sawaguchi, Akira, Manabe, Ichiro, Takatsu, Kiyoshi, Nakauchi, Hiromitsu, Takaki, Satoshi, and Eto, Koji

Subjects
Blood clot -- Development and progression -- Genetic aspects -- Care and treatment -- Research, Integrins -- Properties -- Genetic aspects -- Growth -- Research, Thrombosis -- Development and progression -- Genetic aspects -- Care and treatment -- Research, Cellular signal transduction -- Genetic aspects -- Research -- Growth, Genetic regulation -- Research -- Genetic aspects -- Growth, Blood platelets -- Growth -- Genetic aspects -- Research, Company growth, Health care industry
Abstract

The nature of the in vivo cellular events underlying thrombus formation mediated by platelet activation remains unclear because of the absence of a modality for analysis. Lymphocyte adaptor protein (Lnk; also known as Sh2b3) is an adaptor protein that inhibits thrombopoietin-mediated signaling, and as a result, megakaryocyte and platelet counts are elevated in [Lnk.sup.[-/-]] mice. Here we describe an unanticipated role for Lnk in stabilizing thrombus formation and clarify the activities of Lnk in platelets transduced through integrin αIIbβ3-mediated outside-in signaling. We equalized platelet counts in wild-type and [Lnk.sup.[-/-]] mice by using genetic depletion of Lnk and BM transplantation. Using [FeCl.sub.3]- or laser-induced injury and in vivo imaging that enabled observation of single platelet behavior and the multiple steps in thrombus formation, we determined that Lnk is an essential contributor to the stabilization of developing thrombi within vessels. [Lnk.sup.[-/-]] platelets exhibited a reduced ability to fully spread on fibrinogen and mediate clot retraction, reduced tyrosine phosphorylation of the β3 integrin subunit, and reduced binding of Fyn to integrin αIIbβ3. These results provide new insight into the mechanism of αIIbβ3-based outside-in signaling, which appears to be coordinated in platelets by Lnk, Fyn, and integrins. Outside-in signaling modulators could represent new therapeutic targets for the prevention of cardiovascular events., Introduction Platelet activation is controlled through a series of highly regulated processes and is critical for maintaining normal homeostasis (1). The nature of hemostasis and thrombosis mediated in vivo by [...]

Published
2010
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32. Correction: Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging

Author

Tang, Duozhuang, primary, Tao, Si, additional, Chen, Zhiyang, additional, Koliesnik, Ievgen Oleksandrovich, additional, Calmes, Philip Gerald, additional, Hoerr, Verena, additional, Han, Bing, additional, Gebert, Nadja, additional, Zörnig, Martin, additional, Löffler, Bettina, additional, Morita, Yohei, additional, and Rudolph, Karl Lenhard, additional

Published
2020
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33. Burden of Heart Failure on Patient Daily Life and Patient–Physician Discordance in Disease Management ― Results From a Cross-Sectional Survey in Japan ―

Author

Hayashi, Tomoko, primary, Morita, Yohei, additional, Mitani, Hironobu, additional, Murayama, Hiroki, additional, Anzai, Toshihisa, additional, Studer, Rachel, additional, Cotton, Sarah, additional, Jackson, James, additional, Bailey, Hollie, additional, Kitagawa, Hiroshi, additional, and Oyama, Naotsugu, additional

Published
2020
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39. Elevated Hedgehog activity contributes to attenuated DNA damage responses in aged hematopoietic cells

Author

Scheffold, Annika, primary, Baig, Ali H., additional, Chen, Zhiyang, additional, von Löhneysen, Sarah E., additional, Becker, Friedrich, additional, Morita, Yohei, additional, Avila, Alush I., additional, Groth, Marco, additional, Lechel, André, additional, Schmid, Florian, additional, Kraus, Johann M., additional, Kestler, Hans A., additional, Stilgenbauer, Stephan, additional, Philipp, Melanie, additional, and Burkhalter, Martin D., additional

Published
2019
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42. Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation

Author

Chen, Zhiyang, primary, Amro, Elias Moris, additional, Becker, Friedrich, additional, Hölzer, Martin, additional, Rasa, Seyed Mohammad Mahdi, additional, Njeru, Sospeter Ngoci, additional, Han, Bing, additional, Di Sanzo, Simone, additional, Chen, Yulin, additional, Tang, Duozhuang, additional, Tao, Si, additional, Haenold, Ronny, additional, Groth, Marco, additional, Romanov, Vasily S., additional, Kirkpatrick, Joanna M., additional, Kraus, Johann M., additional, Kestler, Hans A., additional, Marz, Manja, additional, Ori, Alessandro, additional, Neri, Francesco, additional, Morita, Yohei, additional, and Rudolph, K. Lenhard, additional

Published
2018
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43. Telomerase abrogates aneuploidy‐induced telomere replication stress, senescence and cell depletion

Author

Meena, Jitendra K, primary, Cerutti, Aurora, additional, Beichler, Christine, additional, Morita, Yohei, additional, Bruhn, Christopher, additional, Kumar, Mukesh, additional, Kraus, Johann M, additional, Speicher, Michael R, additional, Wang, Zhao‐Qi, additional, Kestler, Hans A, additional, Fagagna, Fabrizio d'Adda di, additional, Günes, Cagatay, additional, and Rudolph, Karl Lenhard, additional

Published
2017
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48. Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging

Author

Tang, Duozhuang, primary, Tao, Si, additional, Chen, Zhiyang, additional, Koliesnik, Ievgen Oleksandrovich, additional, Calmes, Philip Gerald, additional, Hoerr, Verena, additional, Han, Bing, additional, Gebert, Nadja, additional, Zörnig, Martin, additional, Löffler, Bettina, additional, Morita, Yohei, additional, and Rudolph, Karl Lenhard, additional

Published
2016
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49. Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation

Author

Chen, Zhiyang, Amro, Elias Moris, Becker, Friedrich, Hölzer, Martin, Rasa, Seyed Mohammad Mahdi, Njeru, Sospeter Ngoci, Han, Bing, Di Sanzo, Simone, Chen, Yulin, Tang, Duozhuang, Tao, Si, Haenold, Ronny, Groth, Marco, Romanov, Vasily S., Kirkpatrick, Joanna M., Kraus, Johann M., Kestler, Hans A., Marz, Manja, Ori, Alessandro, Neri, Francesco, Morita, Yohei, and Rudolph, K. Lenhard

Abstract

Organism aging is characterized by increased inflammation and decreased stem cell function, yet the relationship between these factors remains incompletely understood. This study shows that aged hematopoietic stem and progenitor cells (HSPCs) exhibit increased ground-stage NF-κB activity, which enhances their responsiveness to undergo differentiation and loss of self-renewal in response to inflammation. The study identifies Rad21/cohesin as a critical mediator of NF-κB signaling, which increases chromatin accessibility in the vicinity of NF-κB target genes in response to inflammation. Rad21 is required for normal differentiation, but limits self-renewal of hematopoietic stem cells (HSCs) during aging and inflammation in an NF-κB–dependent manner. HSCs from aged mice fail to down-regulate Rad21/cohesin and inflammation/differentiation signals in the resolution phase of inflammation. Inhibition of cohesin/NF-κB reverts hypersensitivity of aged HSPCs to inflammation-induced differentiation and myeloid-biased HSCs with disrupted/reduced expression of Rad21/cohesin are increasingly selected during aging. Together, Rad21/cohesin-mediated NF-κB signaling limits HSPC function during aging and selects for cohesin-deficient HSCs with myeloid-skewed differentiation.

Published
2019
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