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1. Evolution of wheat blast resistance gene Rmg8 accompanied by differentiation of variants recognizing the powdery mildew fungus

Author

Asuke, Soichiro, Morita, Kohei, Shimizu, Motoki, Abe, Fumitaka, Terauchi, Ryohei, Nago, Chika, Takahashi, Yoshino, Shibata, Mai, Yoshioka, Motohiro, Iwakawa, Mizuki, Kishi-Kaboshi, Mitsuko, Su, Zhuo, Nasuda, Shuhei, Handa, Hirokazu, Fujita, Masaya, Tougou, Makoto, Hatta, Koichi, Mori, Naoki, Matsuoka, Yoshihiro, Kato, Kenji, and Tosa, Yukio

Published
2024
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2. Fast Primal-Dual Update against Local Weight Update in Linear Assignment Problem and Its Application

Author

Morita, Kohei, Shiroshita, Shinya, Yamaguchi, Yutaro, and Yokoi, Yu

Subjects
Computer Science - Data Structures and Algorithms, Computer Science - Computer Science and Game Theory
Abstract

We consider a dynamic situation in the weighted bipartite matching problem: edge weights in the input graph are repeatedly updated and we are asked to maintain an optimal matching at any moment. A trivial approach is to compute an optimal matching from scratch each time an update occurs. In this paper, we show that if each update occurs locally around a single vertex, then a single execution of Dijkstra's algorithm is sufficient to preserve optimality with the aid of a dual solution. As an application of our result, we provide a faster implementation of the envy-cycle procedure for finding an envy-free allocation of indivisible items. Our algorithm runs in $\mathrm{O}(mn^2)$ time, while the known bound of the original one is $\mathrm{O}(mn^3)$, where $n$ and $m$ denote the numbers of agents and items, respectively., Comment: Accepted by Information Processing Letters; 11 pages

Published
2022

5. Relationship between Radar Cross Section and Optical Magnitude based on Radar and Optical Simultaneous Observations of Faint Meteors

Author

Ohsawa, Ryou, Hirota, Akira, Morita, Kohei, Abe, Shinsuke, Kastinen, Daniel, Kero, Johan, Szasz, Csilla, Fujiwara, Yasunori, Nakamura, Takuji, Nishimura, Koji, Sako, Shigeyuki, Watanabe, Jun-ichi, Aoki, Tsutomu, Arima, Noriaki, Arimatsu, Ko, Doi, Mamoru, Ichiki, Makoto, Ikeda, Shiro, Ita, Yoshifusa, Kasuga, Toshihiro, Kobayashi, Naoto, Kokubo, Mitsuru, Konishi, Masahiro, Maehara, Hiroyuki, Miyata, Takashi, Mori, Yuki, Morii, Mikio, Morokuma, Tomoki, Motohara, Kentaro, Nakada, Yoshikazu, Okumura, Shin-ichiro, Sarugaku, Yuki, Sato, Mikiya, Shigeyama, Toshikazu, Soyano, Takao, Takahashi, Hidenori, Tanaka, Masaomi, Tarusawa, Ken'ichi, Tominaga, Nozomu, Urakawa, Seitaro, Usui, Fumihiko, Yamashita, Takuya, and Yoshikawa, Makoto

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Radar and optical simultaneous observations of meteors are important to understand the size distribution of the interplanetary dust. However, faint meteors detected by high power large aperture radar observations, which are typically as faint as 10 mag. in optical, have not been detected until recently in optical observations, mainly due to insufficient sensitivity of the optical observations. In this paper, two radar and optical simultaneous observations were organized. The first observation was carried out in 2009 to 2010 using Middle and Upper Atmosphere Radar (MU radar) and an image-intensified CCD camera. The second observation was carried out in 2018 using the MU radar and a mosaic CMOS camera, Tomo-e Gozen, mounted on the 1.05-m Kiso Schmidt Telescope. In total, 331 simultaneous meteors were detected. The relationship between radar cross sections and optical V-band magnitudes was well approximated by a linear function. A transformation function from the radar cross section to the V-band magnitude was derived for sporadic meteors. The transformation function was applied to about 150,000 meteors detected by the MU radar in 2009--2015, large part of which are sporadic, and a luminosity function was derived in the magnitude range of $-1.5$ to $9.5$ mag. The luminosity function was well approximated by a single power-law function with the population index of $r = 3.52{\pm}0.12$. The present observation indicates that the MU radar has capability to detect interplanetary dust of $10^{-5}$ to $10^{0}$ g in mass as meteors., Comment: Accepted for publication in Planetary & Space Science. 20 pages, 8 figures

Published
2020
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17. A Novel Filtration Membrane for Clustered Circulating Tumor Cell Extraction: A Prospective Feasibility Study

Author

SAWABATA, NORIYOSHI, primary, MORITA, KOHEI, additional, TATSUMI, SHIGENOBU, additional, FUJII, TOMOMI, additional, NISHIKAWA, TAKESHI, additional, KAWAGUCHI, TAKESHI, additional, ARAKANE, TORU, additional, TOMINAGA, YOSHIAKI, additional, SAKAGUCHI, HIROKAZU, additional, KOBAYASHI, TARO, additional, HONTSU, SHIGETO, additional, YAMAMOTO, YOSHIFUMI, additional, FUJIOKA, NOBUHIRO, additional, OUJI-SAGESHIMA, NORIKO, additional, ITO, TOSHIHIRO, additional, and OHBAYASHI, CHIHO, additional

Published
2023
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18. Evolution of wheat blast resistance gene Rmg8 accompanied by differentiation of variants recognizing the powdery mildew fungus

Author

Asuke, Soichiro, primary, Morita, Kohei, additional, Shimizu, Motoki, additional, Abe, Fumitaka, additional, Terauchi, Ryohei, additional, Nago, Chika, additional, Takahashi, Yoshino, additional, Shibata, Mai, additional, Yoshioka, Motohiro, additional, Iwakawa, Mizuki, additional, Kishi-Kaboshi, Mitsuko, additional, Su, Zhuo, additional, Nasuda, Shuhei, additional, Handa, Hirokazu, additional, Fujita, Masaya, additional, Tougou, Makoto, additional, Hatta, Koichi, additional, Mori, Naoki, additional, Matsuoka, Yoshihiro, additional, Kato, Kenji, additional, and Tosa, Yukio, additional

Published
2023
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22. Evolution of wheat blast resistance gene Rmg8accompanied by differentiation of variants recognizing the powdery mildew fungus

Author

Asuke, Soichiro, Morita, Kohei, Shimizu, Motoki, Abe, Fumitaka, Terauchi, Ryohei, Nago, Chika, Takahashi, Yoshino, Shibata, Mai, Yoshioka, Motohiro, Iwakawa, Mizuki, Kishi-Kaboshi, Mitsuko, Su, Zhuo, Nasuda, Shuhei, Handa, Hirokazu, Fujita, Masaya, Tougou, Makoto, Hatta, Koichi, Mori, Naoki, Matsuoka, Yoshihiro, Kato, Kenji, and Tosa, Yukio

Abstract

Wheat blast, a devastating disease having spread recently from South America to Asia and Africa, is caused by Pyricularia oryzae(synonym of Magnaporthe oryzae) pathotype Triticum, which first emerged in Brazil in 1985. Rmg8and Rmg7, genes for resistance to wheat blast found in common wheat and tetraploid wheat, respectively, recognize the same avirulence gene, AVR-Rmg8. Here we show that an ancestral resistance gene, which had obtained an ability to recognize AVR-Rmg8before the differentiation of Triticumand Aegilops, has expanded its target pathogens. Molecular cloning revealed that Rmg7was an allele of Pm4, a gene for resistance to wheat powdery mildew on 2AL, whereas Rmg8was its homoeologue on 2BL ineffective against wheat powdery mildew. Rmg8variants with the ability to recognize AVR-Rmg8were distributed not only in Triticumspp. but also in Aegilops speltoides, Aegilopsumbellulataand Aegilopscomosa. This result suggests that the origin of resistance gene(s) recognizing AVR-Rmg8dates back to the time before differentiation of A, B, S, U and M genomes, that is, ~5 Myr before the emergence of its current target, the wheat blast fungus. Phylogenetic analyses suggested that, in the evolutionary process thereafter, some of their variants gained the ability to recognize the wheat powdery mildew fungus and evolved into genes controlling dual resistance to wheat powdery mildew and wheat blast.

Published
2024
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23. Clinicopathological and genetic analyses of pulmonary enteric adenocarcinoma

Author

Okada, Fumi, Takeda, Maiko, Fujii, Tomomi, Uchiyama, Tomoko, Sasaki, Shoh, Matsuoka, Minami, Nitta, Yuji, Terada, Chiyoko, Maebo, Katsuya, Morita, Kohei, Ishida, Eiwa, Sawabata, Noriyoshi, and Ohbayashi, Chiho

Abstract

AimsPulmonary enteric adenocarcinoma (PEAC) is a rare variant of pulmonary adenocarcinoma. Due to its rarity, few pathological and molecular studies have been performed on PEAC. We herein conducted clinicopathological, immunohistochemical and molecular analyses of PEAC with a focus on its differentiation from invasive mucinous adenocarcinoma (IMA).MethodsWe examined the clinicopathological features of 16 cases of PEAC and performed a genetic analysis using next-generation sequencing (NGS). The results obtained were compared with those for IMA.ResultsThe average age of patients with PEAC (seven men and nine women) was 72.9 years. A comparison of clinical data on PEAC and IMA revealed no significant differences in age, sex or smoking history. Fifteen PEAC cases had dirty necrosis. Immunohistochemically, the positive rates for each antibody in PEAC were as follows: CK7, 88% (14/16); CK20, 81% (13/16); CDX2, 88% (14/16); p53, 69% (11/16); MUC1, 100% (16/16); MUC2, 19% (3/16); MUC5AC, 69% (11/16); MUC6, 19% (3/16). The positive rates for these antibodies in IMA were 100%, 87%, 0%, 7%, 93%, 0%, 100% and 80%, respectively. EGFRmutations, the METexon 14 skipping mutation, BRAFmutations, the ALKfusion gene and ROS-1fusion gene were not detected in any cases of PEAC or IMA. Among PEAC cases, NGS identified KRASmutations in seven (44%, 7/16) and TP53mutations in nine (56%, 9/16). Among IMA cases, the most commonly mutated gene was KRAS(90%).ConclusionsThe rates of dirty necrosis, immunopositivity for CDX2 and TP53mutations were significantly higher, while that of KRASmutations was significantly lower in PEAC cases than in IMA cases.

Published
2024
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27. Ontological Status of Classicality and Quasi-classicality in Many Worlds Interpretation

Author

Morita, Kohei

Abstract

One of the problems of the many worlds interpretation (MWI) of quantum mechanics is about the ontological status of multiple worlds. In the MWI, the multiple worlds are quasi-classical, and the quasi-classical worlds are considered as emergence and pattern. However, the ontological understanding about the quasi-classical realms remains ambiguous. This article aims to clarify the ontological status of the quasi-classicality in the MWI. In particular, the notion of emergence and pattern has been investigated in the philosophy of science. The investigation about these notions provides a refined ontology of many worlds interpretation., ファイル公開日：2022年4月8日

Published
2022

31. Correlation of MTAP Immunohistochemistry With CDKN2A Status Assessed by Fluorescence In Situ Hybridization and Clinicopathological Features in CNS WHO Grade 2 and 3 Meningiomas: A Single Center Cohort Study

Author

Sasaki, Shoh, Takeda, Maiko, Hirose, Takanori, Fujii, Tomomi, Itami, Hiroe, Uchiyama, Tomoko, Morita, Kohei, Matsuda, Ryosuke, Yamada, Shuichi, Nakagawa, Ichiro, and Ohbayashi, Chiho

Subjects
stomatognathic diseases, hemic and lymphatic diseases, Fluorescence in situ hybridization (FISH), CDKN2A homozygous deletion, MTAP, Meningioma, neoplasms, digestive system diseases, Spatial and temporal heterogeneity
Abstract

CDKN2A homozygous deletion has occasionally been reported in atypical and anaplastic meningiomas and is considered as one of the genetic alterations commonly involved in their recurrence and malignant progression. Methylthioadenosine phosphorylase (MTAP) immunohistochemistry is a promising surrogate marker for CDKN2A homozygous deletion in different cancers but has not been examined in meningiomas. We performed CDKN2A FISH and MTAP immunohistochemistry on specimens from 30 patients with CNS WHO grade 2 (n = 27) and 3 (n = 3) meningiomas, including specimens from primary and recurrent tumors and then determined whether MTAP immunohistochemistry correlated with CDKN2A homozygous deletion and clinicopathological features. CDKN2A homozygous deletion was detected in 12% (3/26) of CNS WHO grade 2 and 67% (2/3) of CNS WHO grade 3 meningiomas; 3 cases exhibited temporal and/or spatial heterogeneity. MTAP loss was in excellent concordance with CDKN2A homozygous deletion (sensitivity; 100%, specificity; 100%). MTAP loss/CDKN2A homozygous deletion correlated with cellular proliferation (mitotic rate; p = 0.001, Ki-67 labeling index; p = 0.03) and poor prognosis (overall survival; p = 0.01, progression free survival; p < 0.001). Thus, MTAP immunostaining can be a surrogate marker for CDKN2A homozygous deletion in meningiomas, and MTAP loss/CDKN2A homozygous deletion may be an important prognostic factor for meningiomas., 博士（医学）・甲第840号・令和4年3月15日, © 2021 American Association of Neuropathologists, Inc. All rights reserved., This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of neuropathology and experimental neurology following peer review. The version of record "Vol.81 issue 2 p.117-126 (2022 Jan 29)" is available online at: https://doi.org/10.1093/jnen/nlab127., 発行元が定める登録猶予期間終了の後、本文を登録予定（2023.02）

Published
2022

34. Clinicopathological and genetic analyses of pulmonary enteric adenocarcinoma

Author

Okada, Fumi, primary, Takeda, Maiko, additional, Fujii, Tomomi, additional, Uchiyama, Tomoko, additional, Sasaki, Shoh, additional, Matsuoka, Minami, additional, Nitta, Yuji, additional, Terada, Chiyoko, additional, Maebo, Katsuya, additional, Morita, Kohei, additional, Ishida, Eiwa, additional, Sawabata, Noriyoshi, additional, and Ohbayashi, Chiho, additional

Published
2022
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36. Aspect and Predicateness of the Second Non-finite Forms of Verbs : Comparing Shiteite and Shite Forms

Author

Morita, Kohei

Subjects
述語, 中止形, アスペクト, 文の成分, 動詞
Abstract

本稿は，動詞の第二中止形の述語らしさについて，アスペクトに注目して記述したものである。分析では，シテとシテイテを比較して相互に言い換えができる場合とできない場合を取り出し，それぞれ定形動詞のアスペクトや中止形の動詞のタイプといった構文的特徴から記述した。そして，中止形のアスペクト的性質や文の成分の観点からシテとシテイテの述語らしさを考察し，次のような結果を得た。定形動詞が完成相の場合，シテイテはアスペクト形式として独立している点で最も述語らしい。定形動詞が継続相の場合には，シテイテとシテは独立したアスペクト形式とは言えないものの，述語らしい機能を果たす場合がある。一方で，シテにはアスペクト対立を持たず，従属的または複合的な関係の中で用いられ，述語らしいとは言えない場合がある。

Published
2021

37. Verification of A New Filter for Isolation of Circulating Tumor Cells by Only Blood Filtration

Author

MORITA, KOHEI, primary, SAWABATA, NORIYOSHI, additional, TATSUMI, SHIGENOBU, additional, FUJII, TOMOMI, additional, NISHIKAWA, TAKASHI, additional, KAWAGUCHI, TAKESHI, additional, ARAKANE, TORU, additional, TOMINAGA, YOSHIAKI, additional, SAKAGUCHI, HIROKAZU, additional, KOBAYASHI, TARO, additional, HONTSU, SHIGETO, additional, YAMAMOTO, YOSHIFUMI, additional, FUJIOKA, NOBUHIRO, additional, OUJI-SAGESHIMA, NORIKO, additional, ITO, TOSHIHIRO, additional, and OHBAYASHI, CHIHO, additional

Published
2022
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38. Identification of fusion transcripts in sarcoma from archival formalin‐fixed paraffin‐embedded tissues: A next‐generation sequencing approach

Author

Fujii, Tomomi, primary, Takeda, Maiko, additional, Uchiyama, Tomoko, additional, Nitta, Yuji, additional, Maebou, Katsuya, additional, Terada, Chiyoko, additional, Okada, Fumi, additional, Matsuoka, Minami, additional, Sugimoto, Sumire, additional, Sasaki, Shoh, additional, Morita, Kohei, additional, Itami, Hiroe, additional, Miyake, Makito, additional, Takeda, Masayuki, additional, Sawabata, Noriyoshi, additional, Fujimoto, Kiyohide, additional, and Ohbayashi, Chiho, additional

Published
2022
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41. <Articles>Invariance in Poincaré's philosophy

Author

MORITA, Kohei

Abstract

It has been widely accepted that one of the foundations of Poincare's philosophy is the notion of the group. However, the roles of the group theory in his philosophy has not been strictly examined. The aim of this paper is to reveal the role of this notion in his epistemology, in particular, philosophy of geometry, philosophy of science, and the objectivity. To look at closer, the important notion for his epistemology is not the group itself, but invariance (even though he does not refer to this term).

Published
2021

42. Spindle‐nucleated cells in cervical liquid‐based cytology: Difficulties in distinguishing between epithelial and non‐epithelial tumours based on morphology.

Author

Toyoda, Shinji, Morita, Kohei, Ishida, Eiwa, Sado, Toshiyuki, and Kita, Tsunekazu

Subjects
*CYTOLOGY, *MORPHOLOGY, *FALLOPIAN tubes, *TUMORS, *CELL morphology
Abstract

Spindle-nucleated cells in cervical liquid-based cytology: Difficulties in distinguishing between epithelial and non-epithelial tumours based on morphology Keywords: liquid-based cytology; uterine cervix; uterine tumours resembling ovarian sex cord tumours EN liquid-based cytology uterine cervix uterine tumours resembling ovarian sex cord tumours 271 274 4 04/12/23 20230501 NES 230501 Uterine tumours resembling ovarian sex cord tumours of the uterine cervix are highly sporadic. Parabasal squamous cells High-grade squamous intraepithelial cells Atypical stromal cells Sex cord-stromal cells What is the final diagnosis based on the findings shown in Figures 1-3?. [Extracted from the article]

Published
2023
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45. Histopathological and epigenetic changes in myocardium associated with cancer therapy‐related cardiac dysfunction

Author

Terada, Chiyoko‐Ikeda, primary, Onoue, Kenji, additional, Fujii, Tomomi, additional, Itami, Hiroe, additional, Morita, Kohei, additional, Uchiyama, Tomoko, additional, Takeda, Maiko, additional, Nakagawa, Hitoshi, additional, Nakano, Tomoya, additional, Baba, Youichirou, additional, Amemiya, Kisaki, additional, Saito, Yoshihiko, additional, Hatakeyama, Kinta, additional, and Ohbayashi, Chiho, additional

Published
2022
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46. Overexpression of microRNA-345 Affects the Invasive Capacity of Pancreatic Ductal Adenocarcinoma Cell Lines by Suppressing MUC1 and TJP2 Expression

Author

Tatsumi, Shigenobu, primary, Fujii, Tomomi, additional, Sugimoto, Aya, additional, Sekita-Hatakeyama, Yoko, additional, Morita, Kohei, additional, Uchiyama, Tomoko, additional, Itami, Hiroe, additional, Takeda, Maiko, additional, Yamazaki, Masaharu, additional, Sho, Masayuki, additional, and Ohbayashi, Chiho, additional

Published
2022
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47. Evaluation of DNA/RNA quality from cell block of malignant mesothelioma and lung adenocarcinoma

Author

Tatsumi, Shigenobu, primary, Takeuchi, Mao, additional, Fujii, Tomomi, additional, Sugimoto, Aya, additional, Sekita‐Hatakeyama, Yoko, additional, Nishikawa, Takeshi, additional, Uchiyama, Tomoko, additional, Morita, Kohei, additional, Itami, Hiroe, additional, Takeda, Maiko, additional, Yamazaki, Masaharu, additional, and Ohbayashi, Chiho, additional

Published
2022
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48. Maintaining Optimality in Assignment Problem against Weight Updates around Vertices

Author

Morita, Kohei, Shiroshita, Shinya, Yamaguchi, Yutaro, and Yokoi, Yu

Subjects
FOS: Computer and information sciences, Computer Science - Computer Science and Game Theory, Computer Science - Data Structures and Algorithms, Data Structures and Algorithms (cs.DS), Computer Science and Game Theory (cs.GT)
Abstract

We consider a dynamic situation in the weighted bipartite matching problem in which edge weights are repeatedly updated and each update occurs around a single vertex. Our objective is to maintain an optimal matching at any moment. A trivial approach is to compute an optimal matching from scratch each time an update occurs, but this seems inefficient. In this paper, we show that, if we simultaneously maintain a dual solution, then it suffices to perform Dijkstra's algorithm only once per update. As an application of our result, we provide a faster implementation of the envy-cycle procedure for finding an envy-free allocation of indivisible goods. Our algorithm runs in $\mathrm{O}(mn^2)$ time, while the known bound of the original one is $\mathrm{O}(mn^3)$, where $n$ and $m$ denote the numbers of agents and items, respectively., Comment: 10 pages

Published
2022
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49. Nationwide surveillance of bacterial respiratory pathogens conducted by the Surveillance Committee of Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Clinical Microbiology in 2009: general view of the pathogens’ antibacterial susceptibility

Author

Watanabe, Akira, Yanagihara, Katsunori, Matsumoto, Tetsuya, Kohno, Shigeru, Aoki, Nobuki, Oguri, Toyoko, Sato, Junko, Muratani, Tetsuro, Yagisawa, Morimasa, Ogasawara, Kazuhiko, Koashi, Naoto, Kozuki, Tsuneo, Komoto, Akira, Takahashi, Yoshisaburo, Tsuji, Toshikatsu, Terada, Michinori, Nakanishi, Kunio, Hattori, Rikizo, Hirako, Yukio, Maruo, Akinori, Minamitani, Shinichi, Morita, Kohei, Wakamura, Tomotaro, Sunakawa, Keisuke, Iwata, Satoshi, Iwamoto, Aikichi, Ezaki, Takayuki, Onodera, Shoichi, Kusachi, Shinya, Tateda, Kazuhiro, Tanaka, Michio, Totsuka, Kyoichi, Niki, Yoshihito, Matsumoto, Tetsuro, Kadota, Junichi, Morinaga, Yoshitomo, Honma, Yasuo, Hanaki, Hideaki, Ohsaki, Yoshinobu, Honda, Yasuhito, Sasaoka, Shoichi, Takeda, Hiroaki, Ikeda, Hideki, Sugai, Atsuko, Miki, Makoto, Nakanowatari, Susumu, Takahashi, Hiroshi, Utagawa, Mutsuko, Kobayashi, Nobuyuki, Takasaki, Jin, Konosaki, Hisami, Aoki, Yasuko, Shoji, Michi, Goto, Hajime, Saraya, Takeshi, Kurai, Daisuke, Okazaki, Mitsuhiro, Kobayashi, Yoshio, Katono, Yasuhiro, Kawana, Akihiko, Saionji, Katsu, Miyazawa, Naoki, Sato, Yoshimi, Watanuki, Yuji, Kudo, Makoto, Ehara, Shigeru, Tsukada, Hiroki, Imai, Yumiko, Watabe, Nobuei, Aso, Sakura, Mikamo, Hiroshige, Yamagishi, Yuka, Takesue, Yoshio, Wada, Yasunao, Nakamura, Tadahiro, Mitsuno, Noriko, Mikasa, Keiichi, Kasahara, Kei, Uno, Kenji, Sano, Reiko, Miyashita, Naoyuki, Kurokawa, Yukinori, Takaya, Mariko, Shimizu, Satomi, Kuwabara, Masao, Watanabe, Yaeko, Doi, Masao, Negayama, Kiyoshi, Hiramatsu, Kazufumi, Honda, Junichi, and Fujita, Masaki

Published
2012
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