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2. Childhood Obesity

Author

Maffeis, Claudio, Licenziati, Maria Rosaria, Vania, Andrea, Garofalo, Piernicola, Di Mauro, Giuseppe, Caroli, Margherita, Morino, Giuseppe, Siani, Paolo, Chiamenti, Giampietro, Sbraccia, Paolo, editor, Nisoli, Enzo, editor, and Vettor, Roberto, editor

Published
2016
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4. Diagnosis, treatment and prevention of pediatric obesity: consensus position statement of the Italian Society for Pediatric Endocrinology and Diabetology and the Italian Society of Pediatrics

Author

Valerio, Giuliana, Maffeis, Claudio, Saggese, Giuseppe, Ambruzzi, Maria Amalia, Balsamo, Antonio, Bellone, Simonetta, Bergamini, Marcello, Bernasconi, Sergio, Bona, Gianni, Calcaterra, Valeria, Canali, Teresa, Caroli, Margherita, Chiarelli, Francesco, Corciulo, Nicola, Crinò, Antonino, Di Bonito, Procolo, Di Pietrantonio, Violetta, Di Pietro, Mario, Di Sessa, Anna, Diamanti, Antonella, Doria, Mattia, Fintini, Danilo, Franceschi, Roberto, Franzese, Adriana, Giussani, Marco, Grugni, Graziano, Iafusco, Dario, Iughetti, Lorenzo, Lamborghini, Adima, Licenziati, Maria Rosaria, Limauro, Raffaele, Maltoni, Giulio, Manco, Melania, Reggiani, Leonardo Marchesini, Marcovecchio, Loredana, Marsciani, Alberto, del Giudice, Emanuele Miraglia, Morandi, Anita, Morino, Giuseppe, Moro, Beatrice, Nobili, Valerio, Perrone, Laura, Picca, Marina, Pietrobelli, Angelo, Privitera, Francesco, Purromuto, Salvatore, Ragusa, Letizia, Ricotti, Roberta, Santamaria, Francesca, Sartori, Chiara, Stilli, Stefano, Street, Maria Elisabeth, Tanas, Rita, Trifiró, Giuliana, Umano, Giuseppina Rosaria, Vania, Andrea, Verduci, Elvira, and Zito, Eugenio

Published
2018
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7. Childhood Obesity

Author

Maffeis, Claudio, primary, Licenziati, Maria Rosaria, additional, Vania, Andrea, additional, Garofalo, Piernicola, additional, Di Mauro, Giuseppe, additional, Caroli, Margherita, additional, Morino, Giuseppe, additional, Siani, Paolo, additional, and Chiamenti, Giampietro, additional

Published
2015
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9. Poor Health Related Quality of Life and Unhealthy Lifestyle Habits in Weight-Loss Treatment-Seeking Youth

Author

Mozzillo, Enza, primary, Zito, Eugenio, additional, Calcaterra, Valeria, additional, Corciulo, Nicola, additional, Di Pietro, Mario, additional, Di Sessa, Anna, additional, Franceschi, Roberto, additional, Licenziati, Maria Rosaria, additional, Maltoni, Giulio, additional, Morino, Giuseppe, additional, Predieri, Barbara, additional, Street, Maria Elisabeth, additional, Trifirò, Giuliana, additional, Gallè, Francesca, additional, Franzese, Adriana, additional, and Valerio, Giuliana, additional

Published
2021
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12. Additional file 1: of Diagnosis, treatment and prevention of pediatric obesity: consensus position statement of the Italian Society for Pediatric Endocrinology and Diabetology and the Italian Society of Pediatrics

Author

Valerio, Giuliana, Maffeis, Claudio, Saggese, Giuseppe, Ambruzzi, Maria, Balsamo, Antonio, Bellone, Simonetta, Bergamini, Marcello, Bernasconi, Sergio, Bona, Gianni, Calcaterra, Valeria, Canali, Teresa, Caroli, Margherita, Chiarelli, Francesco, Corciulo, Nicola, Crinò, Antonino, Procolo Di Bonito, Pietrantonio, Violetta Di, Pietro, Mario Di, Sessa, Anna Di, Diamanti, Antonella, Doria, Mattia, Fintini, Danilo, Franceschi, Roberto, Franzese, Adriana, Giussani, Marco, Grugni, Graziano, Iafusco, Dario, Iughetti, Lorenzo, Adima Lamborghini, Licenziati, Maria, Limauro, Raffaele, Maltoni, Giulio, Manco, Melania, Reggiani, Leonardo, Marcovecchio, Loredana, Marsciani, Alberto, Giudice, Emanuele Del, Morandi, Anita, Morino, Giuseppe, Moro, Beatrice, Nobili, Valerio, Perrone, Laura, Picca, Marina, Pietrobelli, Angelo, Privitera, Francesco, Purromuto, Salvatore, Ragusa, Letizia, Ricotti, Roberta, Santamaria, Francesca, Sartori, Chiara, Stilli, Stefano, Street, Maria, Tanas, Rita, Trifiró, Giuliana, Umano, Giuseppina, Vania, Andrea, Verduci, Elvira, and Zito, Eugenio

Abstract

Level of evidence and grade of recommendations according to the National Guidelines System [4]. (DOCX 15Â kb)

Published
2018
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13. Prevalence of pathogenetic MC4R mutations in Italian children with early Onset obesity, tall stature and familial history of obesity

Author

Crinò Antonino, Balsamo Antonio, Di Pietro Mario, Salvatoni Alessandro, Vottero Alessandra, Iughetti Lorenzo, Morino Giuseppe, Greggio Nella, Tanas Rita, Xiang Zhimin, Cirillo Grazia, Santoro Nicola, Grandone Anna, Haskell-Luevano Carrie, Perrone Laura, and del Giudice Emanuele

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background Melanocortin-4-receptor (MC4R) mutations represent the most frequent genetic cause of non-syndromic early onset obesity. Children carrying MC4R mutations seem to show a particular phenotype characterized by early onset, severe obesity and high stature. To verify whether MC4R mutations are associated with this particular phenotype in the Italian pediatric population, we decided to screen the MC4R gene in a group of obese children selected on the basis of their phenotype. Methods To perform this study, a multicentric approach was designed. Particularly, to be enrolled in the study subjects needed to meet the following criteria: Body mass index ≥ 3 deviation scores according to age and sex, familiar history of obesity (at least one parent obese), obesity onset before the 10 years old, height ≥ 2 deviation scores. The coding region of MC4R gene was screened in 240 obese children (mean age 8.3 ± 3.1, mean BMI 30.8 ± 5.4) and in 200 controls (mean age 8.1 ± 2.8; mean BMI 14.2 ± 2.5). Results Three mutations have been found in five obese children. The S127L (C380T), found in three unrelated children, had been described and functionally characterized previously. The Q307X (C919T) and the Y332H (T994C) mutations were found in two patients. Functional studies showed that only Q307X impaired protein function. Conclusion The low prevalence of MC4R mutations (1.6%) in this group of obese children selected according to the obesity degree, the tall stature and the family history of obesity was similar to the prevalence observed in previous screenings performed in obese adults and in not phenotypically selected obese children.

Published
2009
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23. Prevalence of pathogenetic MC4R mutations in Italian children with early Onset obesity, tall stature and familial history of obesity

Author

Santoro, Nicola, primary, Cirillo, Grazia, additional, Xiang, Zhimin, additional, Tanas, Rita, additional, Greggio, Nella, additional, Morino, Giuseppe, additional, Iughetti, Lorenzo, additional, Vottero, Alessandra, additional, Salvatoni, Alessandro, additional, Di Pietro, Mario, additional, Balsamo, Antonio, additional, Crinò, Antonino, additional, Grandone, Anna, additional, Haskell-Luevano, Carrie, additional, Perrone, Laura, additional, and del Giudice, Emanuele Miraglia, additional

Published
2009
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25. Donizetti: Lucia di Lammermoor.

Author

Coro E Orchestra Del Teatro Di San Carlo Di Napoli, Prefumo, Danilo, producer, Mazzola, Denia, performer, Morino, Giuseppe, performer, Carroli, Silvano, performer, and Bernart, Massimo De, conductor

Published
2002

26. The King of Belcanto.

Author

Warmia National Philharmonic, Nava, Alessandro, producer, Morino, Giuseppe, performer, and Amaducci, Bruno, conductor

Published
2004

27. Gianni di Parigi

Author

Donizetti, Gaetano, 1797-1848., Radiotelevisione italiana. Coro di Milano. Performer, Radiotelevisione italiana. Orchestra sinfonica di Milano. Performer, Cillario, Carlo Felice. Conductor, Morino, Giuseppe. Performer, Romani, Felice, 1788-1865. Librettist, Romero, Angelo, 1940- Performer, and Serra, Luciana. Performer

Published
1988

28. La Sonnambula

Author

(1801), Vincenzo Bellini, composer, Italian International Orchestra, Bratislava Philharmonic Chorus, Ciofi, Patrizia, performer, Morino, Giuseppe, performer, Furlanetto, Giovanni, performer, and Carella, Giuliano, conductor

Published
1995

29. Maria Di Rohan

Author

(1797), Gaetano Donizetti, composer, Orchestra Internazionale d'Italia Opera, Bratislava Philharmonic Chorus, Nava, Alessandro, producer, Prefumo, Danilo, producer, Nicolesco, Mariana, performer, Morino, Giuseppe, performer, Coni, Paolo, performer, and Bernart, Massimo De, conductor

Published
1993

30. Diagnosis, treatment and prevention of pediatric obesity: Consensus position statement of the Italian Society for Pediatric Endocrinology and Diabetology and the Italian Society of Pediatrics

Author

Valerio Nobili, Maria Amalia Ambruzzi, Giuseppina Rosaria Umano, Antonella Diamanti, Maria E. Street, Chiara Sartori, Emanuele Miraglia del Giudice, Valeria Calcaterra, Elvira Verduci, Stefano Stilli, Marcello Bergamini, Dario Iafusco, Teresa Canali, Maria Rosaria Licenziati, Danilo Fintini, G. Trifirò, Anna Di Sessa, Giuseppe Saggese, Margherita Caroli, Adima Lamborghini, Nicola Corciulo, Adriana Franzese, Anita Morandi, Graziano Grugni, Salvatore Purromuto, Gianni Bona, Laura Perrone, Procolo Di Bonito, Claudio Maffeis, S. Bellone, Roberta Ricotti, Francesco Chiarelli, Sergio Bernasconi, Leonardo Marchesini Reggiani, Marina Picca, A. Marsciani, Eugenio Zito, Beatrice Moro, Andrea Vania, Violetta Di Pietrantonio, Giulio Maltoni, Antonio Balsamo, Marco Giussani, Lorenzo Iughetti, L. Ragusa, Melania Manco, Roberto Franceschi, Francesca Santamaria, Giuseppe Morino, Antonino Crinò, Francesco Privitera, Raffaele Limauro, Mattia Doria, Angelo Pietrobelli, Mario Di Pietro, Giuliana Valerio, Loredana Marcovecchio, Rita Tanas, Valerio, Giuliana, Maffeis, Claudio, Saggese, Giuseppe, Amalia Ambruzzi, Maria, Balsamo, Antonio, Bellone, Simonetta, Bergamini, Marcello, Bernasconi, Sergio, Bona, Gianni, Calcaterra, Valeria, Canali, Teresa, Caroli, Margherita, Chiarelli, Francesco, Corciulo, Nicola, Crinò, Antonino, Di Bonito, Procolo, Di Pietrantonio, Violetta, Di Pietro, Mario, Di Sessa, Anna, Diamanti, Antonella, Doria, Mattia, Fintini, Danilo, Franceschi, Roberto, Franzese, Adriana, Giussani, Marco, Grugni, Graziano, Iafusco, Dario, Iughetti, Lorenzo, Lamborghini, Adima, Rosaria Licenziati, Maria, Limauro, Raffaele, Maltoni, Giulio, Manco, Melania, Marchesini Reggiani, Leonardo, Marcovecchio, Loredana, Marsciani, Alberto, Miraglia del Giudice, Emanuele, Morandi, Anita, Morino, Giuseppe, Moro, Beatrice, Nobili, Valerio, Perrone, Laura, Picca, Marina, Pietrobelli, Angelo, Privitera, Francesco, Purromuto, Salvatore, Ragusa, Letizia, Ricotti, Roberta, Santamaria, Francesca, Sartori, Chiara, Stilli, Stefano, Elisabeth Street, Maria, Tanas, Rita, Trifiró, Giuliana, Rosaria Umano, Giuseppina, Vania, Andrea, Verduci, Elvira, Zito, Eugenio, Ambruzzi, Maria Amalia, Licenziati, Maria Rosaria, Reggiani, Leonardo Marchesini, Del Giudice, Emanuele Miraglia, Street, Maria Elisabeth, and Umano, Giuseppina Rosaria

Subjects
Position statement, medicine.medical_specialty, Pediatric Obesity, Evidence-based practice, Consensus, Adolescent, Pediatric endocrinology, 030209 endocrinology & metabolism, Consensu, Disease, Review, Pediatrics, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, 030225 pediatrics, Intervention (counseling), Diagnosis, Medicine, Humans, Child, Societies, Medical, Pediatric, Pediatric obesity, Prevention, Treatment, business.industry, lcsh:RJ1-570, Infant, Newborn, Infant, lcsh:Pediatrics, General Medicine, medicine.disease, Obesity, Diagnosis treatment, Italy, Family medicine, Child, Preschool, business, Psychosocial, Human, Diagnosi
Abstract

The Italian Consensus Position Statement on Diagnosis, Treatment and Prevention of Obesity in Children and Adolescents integrates and updates the previous guidelines to deliver an evidence based approach to the disease. The following areas were reviewed: (1) obesity definition and causes of secondary obesity; (2) physical and psychosocial comorbidities; (3) treatment and care settings; (4) prevention. The main novelties deriving from the Italian experience lie in the definition, screening of the cardiometabolic and hepatic risk factors and the endorsement of a staged approach to treatment. The evidence based efficacy of behavioral intervention versus pharmacological or surgical treatments is reported. Lastly, the prevention by promoting healthful diet, physical activity, sleep pattern, and environment is strongly recommended since the intrauterine phase. Electronic supplementary material The online version of this article (10.1186/s13052-018-0525-6) contains supplementary material, which is available to authorized users.

Published
2018

31. Triglycerides-to-HDL cholesterol ratio as screening tool for impaired glucose tolerance in obese children and adolescents

Author

Giuliana Valerio, Antonio Balsamo, Giuseppe Morino, Mario Di Pietro, Adriana Franzese, Procolo Di Bonito, Melania Manco, Claudio Maffeis, Graziano Grugni, Stefania Di Candia, Manco, Melania, Grugni, Graziano, Di Pietro, Mario, Balsamo, Antonio, Di Candia, Stefania, Morino, Giuseppe Stefano, Franzese, Adriana, Di Bonito, Procolo, Maffeis, Claudio, and Valerio, Giuliana

Subjects
Male, Endocrinology, Diabetes and Metabolism, 030204 cardiovascular system & hematology, Overweight, Impaired glucose tolerance, 0302 clinical medicine, Endocrinology, Mass Screening, Child, Children, education.field_of_study, Pediatric obesity, General Medicine, Cholesterol, Italy, Female, medicine.symptom, Lipoproteins, HDL, medicine.medical_specialty, HDL, Adolescent, Lipoproteins, Population, 030209 endocrinology & metabolism, Triglycerides-to-HDL cholesterol ratio, Waist, 03 medical and health sciences, Diabetes mellitus, Internal medicine, Glucose Intolerance, medicine, Internal Medicine, Humans, Obesity, education, Mass screening, Triglycerides, Case-Control Studies, Cholesterol, HDL, business.industry, Case-control study, nutritional and metabolic diseases, medicine.disease, Impaired fasting glucose, business, Body mass index
Abstract

AIMS:To identify metabolic phenotypes at increased risk of impaired glucose tolerance (IGT) in Italian overweight/obese children (n = 148, age 5-10 years) and adolescents (n = 531, age 10-17.9 year). METHODS:Phenotypes were defined as follows: obesity by the 95th cut-points of the Center for Disease Control body mass index reference standards, impaired fasting glucose (fasting plasma glucose ≥100 mg/dl), high circulating triglycerides (TG), TG/HDL cholesterol ≥2.2, waist-to-height ratio (WTHR) >0.6, and combination of the latter with high TG or TG/HDL cholesterol ≥2.2. RESULTS:In the 148 obese children, TG/HDL-C ≥ 2.2 (OR 20.19; 95 % CI 2.50-163.28, p = 0.005) and the combination of TG/HDL-C ≥ 2.2 and WTHR > 0.60 (OR 14.97; 95 % CI 2.18-102.76, p = 0.006) were significantly associated with IGT. In the 531 adolescents, TG/HDL-C ≥ 2.2 (OR 1.991; 95 % CI 1.243-3.191, p = 0.004) and the combination with WTHR > 0.60 (OR 2.24; 95 % CI 1.29-3.87, p = 0.004) were associated with significantly increased risk of IGT. In the whole sample, having high TG levels according to the NIH National Heart, Lung and Blood Institute Expert Panel was not associated with an increased risk of presenting IGT. CONCLUSIONS:TG/HDL-C ratio can be useful, particularly in children, to identify obese young patients at risk of IGT. Its accuracy as screening tool in a general population needs to be verified. The combination of TG/HDL-C ratio and WTHR > 0.6 did not improve prediction. Having high TG according to the NIH definition was not associated with increased risk of developing IGT.

Published
2016

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