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Your search keyword '"Morimoto, Sakiko"' showing total 11 results
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11 results on '"Morimoto, Sakiko"'

1. Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques

Author

Nagatake, Takahiro, Kishino, Shigenobu, Urano, Emiko, Murakami, Haruka, Kitamura, Nahoko, Konishi, Kana, Ohno, Harumi, Tiwari, Prabha, Morimoto, Sakiko, Node, Eri, Adachi, Jun, Abe, Yuichi, Isoyama, Junko, Sawane, Kento, Honda, Tetsuya, Inoue, Asuka, Uwamizu, Akiharu, Matsuzaka, Takashi, Miyamoto, Yoichi, Hirata, So-ichiro, Saika, Azusa, Shibata, Yuki, Hosomi, Koji, Matsunaga, Ayu, Shimano, Hitoshi, Arita, Makoto, Aoki, Junken, Oka, Masahiro, Matsutani, Akira, Tomonaga, Takeshi, Kabashima, Kenji, Miyachi, Motohiko, Yasutomi, Yasuhiro, Ogawa, Jun, and Kunisawa, Jun

Published
2022
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4. 17(S),18(R)‐epoxyeicosatetraenoic acid generated by cytochrome P450 BM‐3 from Bacillus megaterium inhibits the development of contact hypersensitivity via G‐protein‐coupled receptor 40‐mediated neutrophil suppression

Author

Saika, Azusa, Nagatake, Takahiro, Kishino, Shigenobu, Park, Si‐Bum, Honda, Tetsuya, Matsumoto, Naomi, Shimojou, Michiko, Morimoto, Sakiko, Tiwari, Prabha, Node, Eri, Hirata, So‐ichiro, Hosomi, Koji, Kabashima, Kenji, Ogawa, Jun, and Kunisawa, Jun

Subjects
structure‐activity relationship, lcsh:Biology (General), lipid mediators, epoxy‐fatty acid, anti‐inflammation, lcsh:QH301-705.5, Research Articles, Research Article, dermatitis
Abstract

Dietary intake of ω3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid is beneficial for health control. We recently identified 17,18‐epoxyeicosatetraenoic acid (17,18‐EpETE) as a lipid metabolite endogenously generated from eicosapentaenoic acid that exhibits potent anti‐allergic and anti‐inflammatory properties. However, chemically synthesized 17,18‐EpETE is enantiomeric due to its epoxy group—17(S),18(R)‐EpETE and 17(R),18(S)‐EpETE. In this study, we demonstrated stereoselective differences of 17(S),18(R)‐EpETE and 17(R),18(S)‐EpETE in amelioration of skin contact hypersensitivity and found that anti‐inflammatory activity was detected in 17(S),18(R)‐EpETE, but not in 17(R),18(S)‐EpETE. In addition, we found that cytochrome P450 BM‐3 derived from Bacillus megaterium stereoselectively converts EPA into 17(S),18(R)‐EpETE, which effectively inhibited the development of skin contact hypersensitivity by inhibiting neutrophil migration in a G protein‐coupled receptor 40‐dependent manner. These results suggest the new availability of a bacterial enzyme to produce a beneficial lipid mediator, 17(S),18(R)‐EpETE, in a stereoselective manner. Our findings highlight that bacterial enzymatic conversion of fatty acid is a promising strategy for mass production of bioactive lipid metabolites.

Published
2020

5. ω3 fatty acid metabolite, 12‐hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α

Author

Saika, Azusa, primary, Nagatake, Takahiro, additional, Hirata, So‐ichiro, additional, Sawane, Kento, additional, Adachi, Jun, additional, Abe, Yuichi, additional, Isoyama, Junko, additional, Morimoto, Sakiko, additional, Node, Eri, additional, Tiwari, Prabha, additional, Hosomi, Koji, additional, Matsunaga, Ayu, additional, Honda, Tetsuya, additional, Tomonaga, Takeshi, additional, Arita, Makoto, additional, Kabashima, Kenji, additional, and Kunisawa, Jun, additional

Published
2021
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6. Microbial enzyme stereoselectively converts EPA into 17(S),18(R)-epoxyeicosatetraenoic acid useful for the amelioration of contact hypersensitivity

Author

Saika, Azusa, primary, Nagatake, Takahiro, additional, Kishino, Shigenobu, additional, Park, Si-Bum, additional, Honda, Tetsuya, additional, Matsumoto, Naomi, additional, Shimojou, Michiko, additional, Morimoto, Sakiko, additional, Tiwari, Prabha, additional, Node, Eri, additional, Hirata, So-ichiro, additional, Hosomi, Koji, additional, Kabashima, Kenji, additional, Ogawa, Jun, additional, and Kunisawa, Jun, additional

Published
2020
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7. 17( S ),18( R )‐epoxyeicosatetraenoic acid generated by cytochrome P450 BM‐3 from Bacillus megaterium inhibits the development of contact hypersensitivity via G‐protein‐coupled receptor 40‐mediated neutrophil suppression

Author

Saika, Azusa, primary, Nagatake, Takahiro, additional, Kishino, Shigenobu, additional, Park, Si‐Bum, additional, Honda, Tetsuya, additional, Matsumoto, Naomi, additional, Shimojou, Michiko, additional, Morimoto, Sakiko, additional, Tiwari, Prabha, additional, Node, Eri, additional, Hirata, So‐ichiro, additional, Hosomi, Koji, additional, Kabashima, Kenji, additional, Ogawa, Jun, additional, and Kunisawa, Jun, additional

Published
2019
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8. Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice

Author

Tiwari, Prabha, primary, Nagatake, Takahiro, additional, Hirata, So‐ichiro, additional, Sawane, Kento, additional, Saika, Azusa, additional, Shibata, Yuki, additional, Morimoto, Sakiko, additional, Honda, Tetsuya, additional, Adachi, Jun, additional, Abe, Yuichi, additional, Isoyama, Junko, additional, Tomonaga, Takeshi, additional, Kiyono, Hiroshi, additional, Kabashima, Kenji, additional, and Kunisawa, Jun, additional

Published
2019
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9. The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques

Author

Nagatake, Takahiro, Shiogama, Yumiko, Inoue, Asuka, Kikuta, Junichi, Honda, Tetsuya, Tiwari, Prabha, Kishi, Takayuki, Yanagisawa, Atsushi, Isobe, Yosuke, Matsumoto, Naomi, Shimojou, Michiko, Morimoto, Sakiko, Suzuki, Hidehiko, Hirata, So-ichiro, Steneberg, Pär, Edlund, Helena, Aoki, Junken, Arita, Makoto, Kiyono, Hiroshi, Yasutomi, Yasuhiro, Ishii, Masaru, Kabashima, Kenji, Kunisawa, Jun, Nagatake, Takahiro, Shiogama, Yumiko, Inoue, Asuka, Kikuta, Junichi, Honda, Tetsuya, Tiwari, Prabha, Kishi, Takayuki, Yanagisawa, Atsushi, Isobe, Yosuke, Matsumoto, Naomi, Shimojou, Michiko, Morimoto, Sakiko, Suzuki, Hidehiko, Hirata, So-ichiro, Steneberg, Pär, Edlund, Helena, Aoki, Junken, Arita, Makoto, Kiyono, Hiroshi, Yasutomi, Yasuhiro, Ishii, Masaru, Kabashima, Kenji, and Kunisawa, Jun

Abstract

Background: Metabolites of eicosapentaenoic acid exert various physiologic actions. 17,18-Epoxyeicosatetraenoic acid (17,18-EpETE) is a recently identified new class of antiallergic and anti-inflammatory lipid metabolite of eicosapentaenoic acid, but its effects on skin inflammation and the underlying mechanisms remain to be investigated. Objective: We evaluated the effectiveness of 17,18-EpETE for control of contact hypersensitivity in mice and cynomolgus macaques. We further sought to reveal underlying mechanisms by identifying the responsible receptor and cellular target of 17,18-EpETE. Methods: Contact hypersensitivity was induced by topical application of 2,4-dinitrofluorobenzene. Skin inflammation and immune cell populations were analyzed by using flow cytometric, immunohistologic, and quantitative RT-PCR analyses. Neutrophil mobility was examined by means of imaging analysis in vivo and neutrophil culture in vitro. The receptor for 17,18-EpETE was identified by using the TGF-alpha shedding assay, and the receptor's involvement in the anti-inflammatory effects of 17,18-EpETE was examined by using KO mice and specific inhibitor treatment. Results: We found that preventive or therapeutic treatment with 17,18-EpETE ameliorated contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques. 17,18-EpETE was recognized by G protein-coupled receptor (GPR) 40 (also known as free fatty acid receptor 1) and inhibited chemoattractant-induced Rac activation and pseudopod formation in neutrophils. Indeed, the antiallergic inflammatory effect of 17,18-EpETE was abolished in the absence or inhibition of GPR40. Conclusion: 17,18-EpETE inhibits neutrophil mobility through GPR40 activation, which is a potential therapeutic target to control allergic inflammatory diseases.

Published
2018
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10. The 17,18-epoxyeicosatetraenoic acid–G protein–coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques

Author

Nagatake, Takahiro, primary, Shiogama, Yumiko, additional, Inoue, Asuka, additional, Kikuta, Junichi, additional, Honda, Tetsuya, additional, Tiwari, Prabha, additional, Kishi, Takayuki, additional, Yanagisawa, Atsushi, additional, Isobe, Yosuke, additional, Matsumoto, Naomi, additional, Shimojou, Michiko, additional, Morimoto, Sakiko, additional, Suzuki, Hidehiko, additional, Hirata, So-ichiro, additional, Steneberg, Pär, additional, Edlund, Helena, additional, Aoki, Junken, additional, Arita, Makoto, additional, Kiyono, Hiroshi, additional, Yasutomi, Yasuhiro, additional, Ishii, Masaru, additional, Kabashima, Kenji, additional, and Kunisawa, Jun, additional

Published
2018
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11. Immunological association of inducible bronchus-associated lymphoid tissue organogenesis in Ag85B-rHPIV2 vaccine-induced anti-tuberculosis mucosal immune responses in mice

Author

Nagatake, Takahiro, primary, Suzuki, Hidehiko, additional, Hirata, So-ichiro, additional, Matsumoto, Naomi, additional, Wada, Yasuko, additional, Morimoto, Sakiko, additional, Nasu, Ayaka, additional, Shimojou, Michiko, additional, Kawano, Mitsuo, additional, Ogami, Kentaro, additional, Tsujimura, Yusuke, additional, Kuroda, Etsushi, additional, Iijima, Norifumi, additional, Hosomi, Koji, additional, Ishii, Ken J, additional, Nosaka, Tetsuya, additional, Yasutomi, Yasuhiro, additional, and Kunisawa, Jun, additional

Published
2018
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