Search

Your search keyword '"Morimoto, Hiroki"' showing total 99 results
Start Over Author "Morimoto, Hiroki"
99 results on '"Morimoto, Hiroki"'

3. Neutrophil‐to‐lymphocyte ratio associates with nutritional parameters, intratumoral immune profiles, and clinical outcomes of pembrolizumab in head and neck squamous cell carcinoma.

Author

Morimoto, Hiroki, Tsujikawa, Takahiro, Miyagawa‐Hayashino, Aya, Kimura, Alisa, Saburi, Sumiyo, Murakami, Nanako, Kitamoto, Kayo, Mukudai, Shigeyuki, Nagao, Hikaru, Saya, Shibata, Ogi, Hiroshi, Konishi, Eiichi, Itoh, Kyoko, and Hirano, Shigeru

Subjects
NEUTROPHIL lymphocyte ratio, SQUAMOUS cell carcinoma, HEAD & neck cancer, TUMOR markers, NECK, TREATMENT effectiveness
Abstract

Background: The relationship between the tumor‐immune microenvironment and systemic inflammatory markers, including neutrophil‐to‐lymphocyte ratio (NLR), is unclear. Methods: We examined the characteristics of systemic inflammatory markers and tumor immune microenvironments in relation to treatment outcomes in 29 consecutive patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) who received pembrolizumab, using 14‐marker multiplex immunohistochemistry and image cytometry. Results: NLR ≥4.5 (high NLR) at pretreatment status significantly correlated with short overall survival (OS) and progression‐free survival‐2 (PFS2) and malnutrition status. High NLR in peripheral blood was significantly correlated with low lymphoid cell and high tumor‐associated macrophage counts in tissues, especially myeloid‐to‐lymphoid cell ratios, suggesting an association between circulating and intratumoral immune complexity profiles. Conclusions: This study suggests a link between NLR in circulating blood, systemic nutritional status, and immune composition within the tumor. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

7. Abstract 5172: Tumor-immune microenvironmental profiling during chemo- and targeted therapy for head and neck squamous cell carcinoma

Author

Kimura, Alisa, primary, Tsujikawa, Takahiro, additional, Mitsuda, Junichi, additional, Miyagawa-Hayashino, Aya, additional, Morimoto, Hiroki, additional, Saburi, Sumiyo, additional, Yoshimura, Kanako, additional, Ohmura, Gaku, additional, Mukudai, Sigeyuki, additional, Nagao, Hikaru, additional, Sugiyama, Yoichiro, additional, Ogi, Hiroshi, additional, Shibata, Saya, additional, Konishi, Eiichi, additional, Itoh, Kyoko, additional, and Hirano, Shigeru, additional

Published
2023
Full Text
View/download PDF

8. Abstract 4453: Neutrophil-to-lymphocyte ratio associates with intratumoral myeloid predominance and clinical outcomes of pembrolizumab in head and neck squamous cell carcinoma

Author

Morimoto, Hiroki, primary, Tsujikawa, Takahiro, additional, Miyagawa-Hayashino, Aya, additional, Kimura, Alisa, additional, Saburi, Sumiyo, additional, Mitsuda, Junichi, additional, Yoshimura, Kanako, additional, Ohmura, Gaku, additional, Mukudai, Shigeyuki, additional, Nagao, Hikaru, additional, Sugiyama, Yoichiro, additional, Saya, Shibata, additional, Ogi, Hiroshi, additional, Konishi, Eiichi, additional, Itoh, Kyoko, additional, and Hirano, Shigeru, additional

Published
2023
Full Text
View/download PDF

10. Abstract 5210: Tumor immune characterization identifies age-stratified biomarkers for nivolumab in patients with head and neck squamous cell carcinoma: A nationwide collaborative study in Japan

Author

Tsujikawa, Takahiro, primary, Ohno, Kazuchika, additional, Saburi, Sumiyo, additional, Mitsuda, Junichi, additional, Yoshimura, Kanako, additional, Kimura, Alisa, additional, Morimoto, Hiroki, additional, Ohmura, Gaku, additional, Arai, Akihito, additional, Ogi, Hiroshi, additional, Shibata, Saya, additional, Ariizumi, Yosuke, additional, Tasaki, Akihisa, additional, Takahashi, Ryosuke, additional, Tateishi, Yumiko, additional, Kawabe, Hiroaki, additional, Ikeda, Sadakatsu, additional, Morita, Kei-ichi, additional, Tsunoda, Tatsuhiko, additional, Akashi, Takumi, additional, Kurata, Morito, additional, Imoto, Issei, additional, Shimizu, Yasushi, additional, Watanabe, Akihito, additional, Asada, Yukinori, additional, Hayashi, Ryuichi, additional, Saito, Yuki, additional, Ozawa, Hiroyuki, additional, Tsukahara, Kiyoaki, additional, Oridate, Nobuhiko, additional, Horii, Arata, additional, Maruo, Takashi, additional, Hanai, Nobuhiro, additional, Inohara, Hidenori, additional, Iwai, Hiroshi, additional, Fujii, Takashi, additional, Nibu, Ken-ichi, additional, Iwae, Shigemichi, additional, Ueda, Tsutomu, additional, Yasumatsu, Ryuji, additional, Umeno, Hirohito, additional, Masuda, Muneyuki, additional, Itoh, Kyoko, additional, Hirano, Shigeru, additional, and Asakage, Takahiro, additional

Published
2022
Full Text
View/download PDF

16. A case of thyroid arteriovenous malformation with laryngeal extension

Author

Ikeda, Aoi, primary, Sugiyama, Youichirou, additional, Mitsuda, Junichi, additional, Arai, Akihito, additional, Morimoto, Hiroki, additional, Kimura, Arisa, additional, Yoshimura, Kanako, additional, Saburi, Sumiyo, additional, Oomura, Gaku, additional, Tsujikawa, Takahiro, additional, and Hirano, Shigeru, additional

Published
2022
Full Text
View/download PDF

26. On verbal/nonverbal modality dependence of left and right inferior prefrontal activation during performance of flanker interference task

Author

Morimoto, Hiroki M., Hirose, Satoshi, Chikazoe, Junichi, Jimura, Koji, Asari, Tomoki, Yamashita, Ken-ichiro, Miyashita, Yasushi, and Konishi, Seiki

Subjects
Modality effects -- Research, Prefrontal cortex -- Properties, Prefrontal cortex -- Models, Cerebral hemispheres -- Research, Interference (Perception) -- Research, Verbal ability -- Physiological aspects, Health, Psychology and mental health
Published
2008

28. An interim analysis of malnutrition and prognosis in elderly head and neck cancer patient: Koto-SG multicenter research

Author

Arai, Akihito, primary, Ishizaka, Nariyasu, additional, Tadaki, Nobuhisa, additional, Murakami, Rei, additional, Tameno, Hitosuke, additional, Kayano, Kaori, additional, Tei, Kou, additional, Koike, Shinobu, additional, Nobuhara, Kenji, additional, Okano, Hiroyuki, additional, Morimoto, Hiroki, additional, Omura, Gaku, additional, Tsujikawa, Takahiro, additional, Sugiyama, Yoichiro, additional, and Hirano, Shigeru, additional

Published
2021
Full Text
View/download PDF

29. Front Cover.

Author

Morimoto, Hiroki, Tsujikawa, Takahiro, Miyagawa‐Hayashino, Aya, Kimura, Alisa, Saburi, Sumiyo, Murakami, Nanako, Kitamoto, Kayo, Mukudai, Shigeyuki, Nagao, Hikaru, Saya, Shibata, Ogi, Hiroshi, Konishi, Eiichi, Itoh, Kyoko, and Hirano, Shigeru

Subjects
TREATMENT effectiveness
Abstract

This document is the front cover of an article titled "Neutrophil-to-lymphocyte ratio associates with nutritional parameters, intratumoral immune profiles, and clinical outcomes of pembrolizumab in head and neck squamous cell carcinoma" by Hiroki Morimoto et al. The article explores the relationship between the neutrophil-to-lymphocyte ratio and various factors such as nutritional parameters, immune profiles, and clinical outcomes in patients with head and neck squamous cell carcinoma who received pembrolizumab treatment. The authors of the article are Hiroki Morimoto, Takahiro Tsujikawa, Aya Miyagawa-Hayashino, Alisa Kimura, Sumiyo Saburi, Nanako Murakami, Kayo Kitamoto, Shigeyuki Mukudai, Hikaru Nagao, Shibata Saya, Hiroshi Ogi, Eiichi Konishi, Kyoko Itoh, and Shigeru Hirano. [Extracted from the article]

Published
2024
Full Text
View/download PDF

32. Elevation of circulating neutrophil extracellular traps, interleukin (IL)‐8, IL‐22, and vascular endothelial growth factor in patients with venomous snake mamushi (Gloydius blomhoffii) bites.

Author

Ogura, Yasuaki, Fukuchi, Kensuke, Morimoto, Hiroki, Yuki, Tsurumi, Otsuka, Masaki, Shimauchi, Takatoshi, Honda, Tetsuya, and Tokura, Yoshiki

Abstract

Mamushi bites cause swelling and pain that extend from the bitten site. The coagulopathic, anti‐coagulopathic, and vasculopathic actions of mamushi venom result in various laboratory abnormalities, occasionally with muscular, renal, and other organ damage. We investigated the serum biomarkers that were associated with the pathogenesis of mamushi bites, focusing on markers related to tissue‐damage and neutrophil activation. Twenty patients (one case of grade 2, 13 cases of grade 3, and six cases of grade 4 of severity) seen by us in one summer season were enrolled. Peripheral blood samples were taken from the patients on day 0, day 2, and day 7 after mamushi bites. In addition to routine blood examination, serum samples were subjected to enzyme‐linked immunosorbent assay for citrullinated histone H3 (CitH3), interleukin (IL)‐8, IL‐17A, IL‐22, vascular endothelial growth factor (VEGF), high mobility group box protein 1 (HMGB1), tumor necrosis factor (TNF)‐α, and IL‐33. Creatinine kinase (CK) values significantly correlated with prothrombin time (PT) levels, suggesting that muscular damage is associated with exaggerated coagulation and fibrinolysis. In the vast majority of patients, HMGB1, TNF‐α, and IL‐33 were under detection levels. Neutrophil counts did not correlate with PT or CK, indicating that the coagulation disorder and muscular damage were virtually independent of the neutrophil activation. The neutrophil number significantly correlated with CitH3, a representative marker of neutrophil extracellular traps. Moreover, there were significant correlations between neutrophil number, CitH3, IL‐8, IL‐22, and VEGF. Our study suggests that there are two major cascades in mamushi bites. One is an already characterized venom effect on coagulation, vessels, and muscles. In the other novel cascade, we propose that neutrophil activation with IL‐8 leads to the production of IL‐22 and VEGF. This sequential event may contribute to both vascular damage and repair. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

34. Spatially resolved immune microenvironmental profiling for follicular thyroid carcinoma with minimal capsular invasion

Author

Saburi, Sumiyo, Tsujikawa, Takahiro, Miyagawa-Hayashino, Aya, Mitsuda, Junichi, Yoshimura, Kanako, Kimura, Alisa, Morimoto, Hiroki, Ohmura, Gaku, Arai, Akihito, Ogi, Hiroshi, Konishi, Eiichi, Itoh, Kyoko, Sugino, Kiminori, and Hirano, Shigeru

Abstract

Spatial profiles of the tumor-immune microenvironment are associated with disease progression and clinicopathological factors in various cancers. Follicular thyroid carcinoma (FTC) is the second most common thyroid cancer, where the presence of capsular invasion or angioinvasion determines the pathological diagnosis; however, little is known about the immune microenvironment profiles associated with the acquisition of invasive potential of FTC. In this study, we focused on FTC with minimal capsular invasion, and the spatially resolved immune microenvironment of FTC was studied in the discovery (n= 13) and validation cohorts (n= 40). CD8+T cells, helper T cells, regulatory T cells, B cells, natural killer cells, tumor-associated macrophages, CD66+granulocytes, mature dendritic cells, and mast cells were quantitatively evaluated in single tissue sections, via a 12-marker multiplex immunohistochemistry and image cytometry. Cell densities and compositions of immune cells were spatially stratified by six tissue regions including tumor center, subcapsular region, capsular invasion, adjacent stroma of capsular invasion, peritumoral stroma, and adjacent normal. Lymphoid cell lineages in the tumor center and subcapsular regions were significantly lower than those in adjacent normal and peritumoral stroma, potentially related to the lymphoid lineage exclusion from the intratumoral regions of FTC. Interestingly, immune cell composition profiles in the capsular invasive front were distinct from those of intratumoral region. The ratios of T cells to CD66b+granulocytes with capsular invasion were significantly higher than those without capsular invasion, suggesting the presence of a unique immune microenvironment at the invasive front between tumor foci and stroma. In addition, tumor cells at the capsular invasive front showed significantly higher expression of tumor programmed cell death ligand 1 (PD-L1) than those at the tumor center. This study revealed spatial immune profiles associated with capsular invasion of FTC, providing new insights into the mechanisms underlying its development and initial invasion.

Published
2021
Full Text
View/download PDF

36. Loss of Runt-related transcription factor 3 induces resistance to 5-fluorouracil and cisplatin in hepatocellular carcinoma

Author

Kataoka, Junro, primary, Shiraha, Hidenori, additional, Horiguchi, Shigeru, additional, Sawahara, Hiroaki, additional, Uchida, Daisuke, additional, Nagahara, Teruya, additional, Iwamuro, Masaya, additional, Morimoto, Hiroki, additional, Takeuchi, Yasuto, additional, Kuwaki, Kenji, additional, Onishi, Hideki, additional, Nakamura, Shinichiro, additional, Takaki, Akinobu, additional, Nouso, Kazuhiro, additional, Yagi, Takahito, additional, Yamamoto, Kazuhide, additional, and Okada, Hiroyuki, additional

Published
2017
Full Text
View/download PDF

39. Loss of Runt-related transcription factor 3 induces resistance to 5-fluorouracil and cisplatin in hepatocellular carcinoma

Author

KATAOKA, JUNRO, primary, SHIRAHA, HIDENORI, additional, HORIGUCHI, SHIGERU, additional, SAWAHARA, HIROAKI, additional, UCHIDA, DAISUKE, additional, NAGAHARA, TERUYA, additional, IWAMURO, MASAYA, additional, MORIMOTO, HIROKI, additional, TAKEUCHI, YASUTO, additional, KUWAKI, KENJI, additional, ONISHI, HIDEKI, additional, NAKAMURA, SHINICHIRO, additional, TAKAKI, AKINOBU, additional, NOUSO, KAZUHIRO, additional, YAGI, TAKAHITO, additional, YAMAMOTO, KAZUHIDE, additional, and OKADA, HIROYUKI, additional

Published
2016
Full Text
View/download PDF

42. Paraphenylenediamine ingredient possibly contributes to granuloma formation in inflammatory tattoo.

Author

Ogura, Yasuaki, Morimoto, Hiroki, Otsuka, Masaki, and Tokura, Yoshiki

Subjects
*TATTOOING, *GRANULOMA
Abstract

A case study of a 67-year-old Japanese man was referred to us because of a 20-year history of itchy reddish change in permanent tattoo and report an erythematous indurated eruption congruous with a dermally injected permanent tattoo in a patient who had contact dermatitis to paraphenylenediamine .

Published
2022
Full Text
View/download PDF

43. Postpartum polymorphic eruption of pregnancy prominently occurring on striae distensae.

Author

Ogura, Yasuaki, Inuzuka, Manabu, Morimoto, Hiroki, Otsuka, Masaki, and Tokura, Yoshiki

Subjects
PREGNANCY, PUERPERIUM, THIRD trimester of pregnancy
Abstract

A case study of a 27-year-old primigravida was referred to us for evaluation of her skin lesions, in which she developed an eruption on the abdomen, extending to the thighs, after delivery of a first female baby, except for the mother's transient anemia improved by one-dose blood transfusion.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results