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Your search keyword '"Morikawa, Akihiro"' showing total 910 results
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910 results on '"Morikawa, Akihiro"'

9. Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial

Author

Kobayashi, Tohru, Saji, Tsutomu, Otani, Tetsuya, Takeuchi, Kazuo, Nakamura, Tetsuya, Arakawa, Hirokazu, Kato, Taichi, Hara, Toshiro, Hamaoka, Kenji, Ogawa, Shunichi, Miura, Masaru, Nomura, Yuichi, Fuse, Shigeto, Ichida, Fukiko, Seki, Mitsuru, Fukazawa, Ryuji, Ogawa, Chitose, Furuno, Kenji, Tokunaga, Hirohide, Takatsuki, Shinichi, Hara, Shinya, and Morikawa, Akihiro

Published
2012
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10. Effects of ketoprofen for prevention of postoperative cognitive dysfunction in aged rats

Author

Kawano, Takashi, Takahashi, Tetsuya, Iwat, Hideki, Morikawa, Akihiro, Imori, Satoko, Waki, Sayaka, Tamura, Takahiko, Yamazaki, Fumimoto, Eguchi, Satoru, Kumagai, Naoko, and Yokoyama, Masataka

Subjects
Medical research, Medicine, Experimental, Analgesia -- Research, Ketoprofen -- Dosage and administration, Cognition disorders -- Prevention, Health
Abstract

Postoperative cognitive dysfunction is a common geriatric complication that may be associated with increased mortality. Here, we investigated the effects of postoperative analgesia with ketoprofen on cognitive functions in aged animals and compared its effectiveness to morphine. Rats were randomly allocated to one of four groups: isoflurane anesthesia without surgery (group C), isoflurane anesthesia with laparotomy (group IL), and isoflurane anesthesia with laparotomy plus postoperative analgesia with ketoprofen or morphine. There was no difference in postoperative locomotor activity among groups. In group IL, postoperative pain levels assessed by the Rat Grimace Scale significantly increased until 8 h after surgery, which was similarly inhibited by both ketoprofen and morphine. Cognitive function was assessed using radial arm maze testing for 12 consecutive days from postoperative day 3. Results showed that the number of memory errors in group IL were significantly higher than those in goup C. However, both ketoprofen and morphine could attenuate the increase in memory errors following surgery to a similar degree. Conversely, ketoprofen showed no effect on cognitive function in the nonsurgical rats that did not experience pain. Our findings suggest that postoperative analgesia with ketoprofen can prevent the development of surgery-associated memory deficits via its pain-relieving effects. Keywords Rehabilitation * Inflammation * Cognitive dysfunction * Aged rats, Postoperative cognitive dysfunction (POCD) is a mild but possibly long-lasting decline in cognitive function after anesthesia and surgery [1, 2]. Current literature has consistently shown that POCD is more frequent [...]

Published
2014
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14. Preventive effects of multisensory rehabilitation on development of cognitive dysfunction following systemic inflammation in aged rats

Author

Kawano, Takashi, Morikawa, Akihiro, Imori, Satoko, Waki, Sayaka, Tamura, Takahiko, Yamanaka, Daiki, Yamazaki, Fumimoto, and Yokoyama, Masataka

Subjects
Inflammation -- Research -- Risk factors, Cognition in children -- Research, Cognition disorders -- Research -- Care and treatment -- Patient outcomes -- Complications and side effects, Health
Abstract

Systemic inflammation can trigger transient or longer-lasting cognitive impairments, particularly in elderly patients. However, its pathogenesis has not been sufficiently clarified. In this study, we explored the potential effects of multisensory rehabilitation on cognitive dysfunction following systemic inflammation using an animal model. Aged male Wister rats were randomly injected intraperitoneally with either saline (control) or lipopolysaccharide (LPS; 5 mg/kg). After injection, both groups of rats were randomly assigned to either of two housing conditions (n = 8 in each condition): a standard cage environment (SC group) or a multisensory early rehabilitation environment (ER group). Cognitive function was examined after 7 days in the assigned environmental condition using a novel object recognition test. In the SC group, the LPS-treated rats showed impaired cognitive function compared with the control animals. These memory deficits were positively correlated with the levels of both tumor necrosis factor (TNF)-α and interleukin (IL)-1β in the hippocampus. On the other hand, in the LPS-treated ER group, neither cognitive impairment nor an increase in hippocampal levels of both TNF-α and IL-1β was found. These results imply that early rehabilitation (ER) intervention may be effective in preventing cognitive dysfunction following systemic inflammation via its anti-neuroinflammatory effects. Keywords Rehabilitation * Inflammation * Cognitive dysfunction * Aged rats, Systemic acute inflammation secondary to infection and tissue injury is reported to induce various cognitive complications, e.g., delirium and postoperative cognitive dysfunction [1-3]. These inflammation-associated cognitive disorders commonly occur in [...]

Published
2014
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17. Japanese pediatric guideline for the treatment and management of bronchial asthma 2012

Author

Hamasaki, Yuhei, Kohno, Yoichi, Ebisawa, Motohiro, Kondo, Naomi, Nishima, Sankei, Nishimuta, Toshiyuki, Morikawa, Akihiro, Aihara, Yukoh, Akasawa, Akira, Adachi, Yuichi, Arakawa, Hirokazu, Ikebe, Toshiichi, Ichikawa, Kunio, Inoue, Toshishige, Iwata, Tsutomu, Urisu, Atsuo, Ohya, Yukihiro, Okada, Kenji, Odajima, Hiroshi, Katsunuma, Toshio, Kameda, Makoto, Kurihara, Kazuyuki, Sakamoto, Tatsuo, Shimojo, Naoki, Suehiro, Yutaka, Tokuyama, Kenichi, Nambu, Mitsuhiko, Fujisawa, Takao, Matsui, Takehiko, Matsubara, Tomoyo, Mayumi, Mitsufumi, Mochizuki, Hiroyuki, Yamaguchi, Koichi, and Yoshihara, Shigemi

Published
2014
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21. Study of nasopharyngeal bacterial flora. Variations in nasopharyngeal bacterial flora in schoolchildren and adults when administered antimicrobial agents

Author

Konno, Masatoshi, Baba, Shunkichi, Mikawa, Haruki, Hara, Kohei, Matsumoto, Fumio, Kaga, Kimitaka, Nishimura, Tadao, Kobayashi, Toshimitsu, Furuya, Nobuhiko, Moriyama, Hiroshi, Okamoto, Yoshitaka, Furukawa, Mituru, Yamanaka, Noboru, Matsushima, Toshiharu, Yoshizawa, Yasuyuki, Kohno, Shigeru, Kobayashi, Kunihiko, Morikawa, Akihiro, Koizumi, Shoichi, Sunakawa, Keisuke, Inoue, Matsuhisa, and Ubukata, Kimiko

Published
2007
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22. Study of nasopharyngeal bacterial flora. Second report. Variations in nasopharyngeal bacterial flora in children aged 6 years or younger when administered antimicrobial agents. Part 2

Author

Konno, Masatoshi, Baba, Shunkichi, Mikawa, Haruki, Hara, Kohei, Matsumoto, Fumio, Kaga, Kimitaka, Nishimura, Tadao, Kobayashi, Toshimitsu, Furuya, Nobuhiko, Moriyama, Hiroshi, Okamoto, Yoshitaka, Furukawa, Mituru, Yamanaka, Noboru, Matsushima, Toshiharu, Yoshizawa, Yasuyuki, Kohno, Shigeru, Kobayashi, Kunihiko, Morikawa, Akihiro, Koizumi, Shoichi, Sunakawa, Keisuke, Inoue, Matsuhisa, and Ubukata, Kimiko

Published
2006
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23. Study of nasopharyngeal bacterial flora. Second report. Variations in nasopharyngeal bacterial flora in children aged 6 years or younger when administered antimicrobial agents. Part 1

Author

Konno, Masatoshi, Baba, Shunkichi, Mikawa, Haruki, Hara, Kohei, Matsumoto, Fumio, Kaga, Kimitaka, Nishimura, Tadao, Kobayashi, Toshimitsu, Furuya, Nobuhiko, Moriyama, Hiroshi, Okamoto, Yoshitaka, Furukawa, Mituru, Yamanaka, Noboru, Matsushima, Toshiharu, Yoshizawa, Yasuyuki, Kohno, Shigeru, Kobayashi, Kunihiko, Morikawa, Akihiro, Koizumi, Shoichi, Sunakawa, Keisuke, Inoue, Matsuhisa, and Ubukata, Kimiko

Published
2006
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24. Study of upper respiratory tract bacterial flora: first report. Variations in upper respiratory tract bacterial flora in patients with acute upper respiratory tract infection and healthy subjects and variations by subject age

Author

Konno, Masatoshi, Baba, Shunkichi, Mikawa, Haruki, Hara, Kohei, Matsumoto, Fumio, Kaga, Kimitaka, Nishimura, Tadao, Kobayashi, Toshimitsu, Furuya, Nobuhiko, Moriyama, Hiroshi, Okamoto, Yoshitaka, Furukawa, Mituru, Yamanaka, Noboru, Matsushima, Toshiharu, Yoshizawa, Yasuyuki, Kohno, Shigeru, Kobayashi, Kunihiko, Morikawa, Akihiro, Koizumi, Shoichi, Sunakawa, Keisuke, Inoue, Matsuhisa, and Ubukata, Kimiko

Published
2006
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39. Japanese pediatric guidelines for the treatment and management of bronchial asthma 2008

Author

Kondo, Naomi, Nishimuta, Toshiyuki, Nishima, Sankei, Morikawa, Akihiro, Aihara, Yukoh, Akasaka, Toru, Akasawa, Akira, Adachi, Yuichi, Arakawa, Hirokazu, Ikarashi, Takao, Ikebe, Toshiichi, Inoue, Toshishige, Iwata, Tsutomu, Urisu, Atsuo, Ebisawa, Motohiro, Ohya, Yukihiro, Okada, Kenji, Odajima, Hiroshi, Katsunuma, Toshio, Kameda, Makoto, Kurihara, Kazuyuki, Kohno, Yoichi, Sakamoto, Tatsuo, Shimojo, Naoki, Suehiro, Yutaka, Tokuyama, Kenichi, Nambu, Mitsuhiko, Hamasaki, Yuhei, Fujisawa, Takao, Matsui, Takehiko, Matsubara, Tomoyo, Mayumi, Mitsufumi, Mukoyama, Tokuko, Mochizuki, Hiroyuki, Yamaguchi, Koichi, and Yoshihara, Shigemi

Published
2010
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