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18 results on '"Morihara, Keisuke"'

5. Father-to-offspring transmission of extremely long NOTCH2NLC repeat expansions with contractions: genetic and epigenetic profiling with long-read sequencing

Author

Fukuda, Hiromi, Yamaguchi, Daisuke, Nyquist, Kristofor, Yabuki, Yasushi, Miyatake, Satoko, Uchiyama, Yuri, Hamanaka, Kohei, Saida, Ken, Koshimizu, Eriko, Tsuchida, Naomi, Fujita, Atsushi, Mitsuhashi, Satomi, Ohbo, Kazuyuki, Satake, Yuki, Sone, Jun, Doi, Hiroshi, Morihara, Keisuke, Okamoto, Tomoko, Takahashi, Yuji, Wenger, Aaron M., Shioda, Norifumi, Tanaka, Fumiaki, Matsumoto, Naomichi, and Mizuguchi, Takeshi

Published
2021
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7. Reduced likelihood of the Poggendorff illusion in cerebellar strokes: a clinical and neuroimaging study

Author

Higashiyama, Yuichi, primary, Kuroki, Miho, additional, Kudo, Yosuke, additional, Hamada, Tomoya, additional, Morihara, Keisuke, additional, Saito, Asami, additional, Miyaji, Yosuke, additional, Kimura, Katsuo, additional, Joki, Hideto, additional, Kishida, Hitaru, additional, Doi, Hiroshi, additional, Ueda, Naohisa, additional, Takeuchi, Hideyuki, additional, Johkura, Ken, additional, and Tanaka, Fumiaki, additional

Published
2023
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9. Qualitative Deficits in Verbal Fluency in Parkinson’s Disease with Mild Cognitive Impairment: A Clinical and Neuroimaging Study

Author

Hamada, Tomoya, primary, Higashiyama, Yuichi, additional, Saito, Asami, additional, Morihara, Keisuke, additional, Landin-Romero, Ramon, additional, Okamoto, Mitsuo, additional, Kimura, Katsuo, additional, Miyaji, Yousuke, additional, Joki, Hideto, additional, Kishida, Hitaru, additional, Doi, Hiroshi, additional, Ueda, Naohisa, additional, Takeuchi, Hideyuki, additional, and Tanaka, Fumiaki, additional

Published
2021
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10. Usefulness of rapid MR angiography using two-point Dixon for evaluating carotid and aortic plaques

Author

Morihara, Keisuke, primary, Nakano, Tatsu, additional, Mori, Kentaro, additional, Fukui, Issei, additional, Nomura, Motohiro, additional, Suzuki, Keiichiro, additional, Hirano, Kenichi, additional, Takahashi, Mitsuyuki, additional, Takeuchi, Hideyuki, additional, Doi, Hiroshi, additional, Kitamura, Yoshihisa, additional, and Tanaka, Fumiaki, additional

Published
2021
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11. Additional file 1 of Father-to-offspring transmission of extremely long NOTCH2NLC repeat expansions with contractions: genetic and epigenetic profiling with long-read sequencing

Author

Fukuda, Hiromi, Yamaguchi, Daisuke, Nyquist, Kristofor, Yabuki, Yasushi, Miyatake, Satoko, Uchiyama, Yuri, Hamanaka, Kohei, Saida, Ken, Koshimizu, Eriko, Tsuchida, Naomi, Fujita, Atsushi, Mitsuhashi, Satomi, Ohbo, Kazuyuki, Satake, Yuki, Sone, Jun, Doi, Hiroshi, Morihara, Keisuke, Okamoto, Tomoko, Takahashi, Yuji, Wenger, Aaron M., Shioda, Norifumi, Tanaka, Fumiaki, Matsumoto, Naomichi, and Mizuguchi, Takeshi

Abstract

Additional file 1: Fig. S1. De novo NOTCH2NLC repeat expansion are suspected by RP-PCR; Fig. S2. Long repeat expansion of asymptomatic carrier fathers was confirmed by Southern blot analysis; Fig. S3. Maternal transmission of non-expanded allele as indicated by AL-PCR; Fig. S4. Polymerase kinetics study suggesting DNA base modification in asymptomatic carrier fathers; Fig. S5. Nanopore methylation analysis revealed gain of 5-mC in the asymptomatic carrier father (F2-father); Fig. S6. Consensus sequence of expanded and non-expanded alleles using PacBio HiFi reads; Fig. S7. Read-based methylation plots of 12 individuals; Fig. S8. Bimodal distribution of non-expanded and expanded alleles in the LCLs from the F4-father, not suggesting somatic mosaicism; Fig. S9. Read-based methylation plots for the F4-patient, showing the gain of 5-mC in the small percentage of disease-causing allele (median 162 repeat units); Fig. S10. Full unedited image for Fig. 3b and S2.

Published
2021
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13. Seen by a Glance, But Not by a Stare—A Case Study of a Patient With Simultanagnosia.

Author

Morihara, Keisuke, Higashiyama, Yuichi, Asano, Shiori, Matsunaga, Yuki, Takahashi, Keita, Miyake, Ryoko, Tanaka, Kenichi, Joki, Hideto, Doi, Hiroshi, Takeuchi, Hideyuki, and Tanaka, Fumiaki

Subjects
*VISUAL perception, *UNILATERAL neglect, *PERCEPTION testing, *CEREBRAL infarction, *SYMPTOMS, *RECTAL prolapse
Abstract

Objective Simultanagnosia is a rare neuropsychological symptom characterized by difficulty recognizing global structures while preserving perception of local detail. The condition is classified into ventral and dorsal types. Clinical presentation of ventral simultanagnosia includes a reduced ability to recognize multiple visual stimuli rapidly, that is, part-by-part recognition. Here, we report a case of ventral simultanagnosia with a unique presentation; when short-duration visual stimuli were presented, the patient could perform global recognition by improving his part-by-part approach. To investigate the relationship between local and global perception bias and the duration of the present stimulus, we conducted a visual perception test using hierarchically organized Navon figures. Methods/Results The patient was a 62-year-old right-handed man who suffered from cerebral infarction in the right occipitotemporal lobe. He had no language dysfunction but exhibited left unilateral neglect, prosopagnosia, and ventral-type simultanagnosia. We conducted a visual perception test using the Navon figures and control figures as a visual stimulus. We randomly presented the figures for intervals of 0.2 or 20 s and let the patient report all the letters (global and/or local element) that he recognized. Global elements of the Navon letter were recognized a rate of 0% and 78.3% at intervals of 20 and 0.2 s, respectively, indicating that shorter presentation made the part-by-part approach less likely to manifest. Conclusions We assumed that the simultanagnosia in this case was caused by failure to maintain the initially perceived global information for a long period of time during visual presentation, due to right occipitotemporal damage. [ABSTRACT FROM AUTHOR]

Published
2022
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15. Neural mechanisms of foreign accent syndrome: Lesion and network analysis

Author

Higashiyama, Yuichi, primary, Hamada, Tomoya, additional, Saito, Asami, additional, Morihara, Keisuke, additional, Okamoto, Mitsuo, additional, Kimura, Katsuo, additional, Joki, Hideto, additional, Kishida, Hitaru, additional, Doi, Hiroshi, additional, Ueda, Naohisa, additional, Takeuchi, Hideyuki, additional, and Tanaka, Fumiaki, additional

Published
2021
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16. GGC Repeat Expansion of NOTCH2NLC in Adult Patients with Leukoencephalopathy

Author

Okubo, Masaki, primary, Doi, Hiroshi, additional, Fukai, Ryoko, additional, Fujita, Atsushi, additional, Mitsuhashi, Satomi, additional, Hashiguchi, Shunta, additional, Kishida, Hitaru, additional, Ueda, Naohisa, additional, Morihara, Keisuke, additional, Ogasawara, Akihiro, additional, Kawamoto, Yuko, additional, Takahashi, Tatsuya, additional, Takahashi, Keita, additional, Nakamura, Haruko, additional, Kunii, Misako, additional, Tada, Mikiko, additional, Katsumoto, Atsuko, additional, Fukuda, Hiromi, additional, Mizuguchi, Takeshi, additional, Miyatake, Satoko, additional, Miyake, Noriko, additional, Suzuki, Junichiro, additional, Ito, Yasuhiro, additional, Sone, Jun, additional, Sobue, Gen, additional, Takeuchi, Hideyuki, additional, Matsumoto, Naomichi, additional, and Tanaka, Fumiaki, additional

Published
2019
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