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2. Multizentrische, randomisierte Phase III-Studie zur Magnetresonanztomographie-gesteuerten hochfokussierten Ultraschalltherapie zur Behandlung des Uterusmyoms (MRgFUS-TUF) im Vergleich zur Myomektomie bei symptomatischen und medikamentös nicht ausreichend therapierbaren Uterusmyomen (MARGI-T)

Author

Götze, TO, additional, Al-Batran, S-E, additional, Bankstahl, US, additional, Fleckenstein, A-S, additional, Engel, JB, additional, Aktas, B, additional, Martin, M, additional, Weisgerber, C, additional, Hunold, P, additional, Gallwas, J, additional, Kulenkampff, D, additional, Maintz, D, additional, Morgenstern, B, additional, Püsken, M, additional, Keim, S, additional, Matzko, M, additional, and Düx, M, additional

Published
2022
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8. Multicentric, randomized Phase III Trial of Magnetic Resonance Imaging-guided highly focused Ultrasound Therapy for the Treatment of Uterine Fibroid (MRgFUS-TUF) Patients versus Myomectomy for symptomatic and drug-naive Uterine Fibroid (MARGI-T) Patients

Author

Gotze, T. O., Al-Batran, S-E, Bankstahl, U. S., Fleckenstein, A-S, Engel, J. B., Aktas, B., Martin, M., Weisgerber, C., Hunold, P., Gallwas, J., Kulenkampff, D., Maintz, D., Morgenstern, B., Puesken, M., Keim, S., Matzko, M., Duex, M., Gotze, T. O., Al-Batran, S-E, Bankstahl, U. S., Fleckenstein, A-S, Engel, J. B., Aktas, B., Martin, M., Weisgerber, C., Hunold, P., Gallwas, J., Kulenkampff, D., Maintz, D., Morgenstern, B., Puesken, M., Keim, S., Matzko, M., and Duex, M.

Published
2022

9. Laparoskopische bilaterale Uterosakropexie zur apikalen Rekonstruktion ��� Weiterentwicklung einer Technik zum Ersatz beider Uterosakralligamente unter Erhalt des Uterus

Author

Ludwig, S, Morgenstern, B, Thangarajah, F, Brandt, J, and Mallmann, P

Subjects
ddc: 610, Medicine and health
Abstract

Einleitung: Symptomatische Senkungen der Geb��rmutter kommen auch bei pr��menopausalen Frauen vor. Sind konservative Ma��nahmen ausgesch��pft und besteht z.B. noch Kinderwunsch oder ist aus unterschiedlichen Gr��nden der Geb��rmutterhalt gew��nscht, so sind operative Therapieoptionen [zum vollst��ndigen Text gelangen Sie ��ber die oben angegebene URL]

Published
2021
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28. Hypertension — Diagnosis and Treatment

Author

Adelman, R. D., Gruskin, A. B., Baluarte, H. J., Kaiser, B. A., Polinsky, M. S., Morgenstern, B. Z., Perlman, S. A., Dillon, M. J., Mongeau, J. G., Brodehl, Johannes, editor, and Ehrich, Jochen H. H., editor

Published
1984
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29. jpHMM: recombination analysis in viruses with circular genomes such as the hepatitis B virus

Author

Schultz, A.-K., Bulla, I., Abdou-Chekaraou, M., Gordien, E., Morgenstern, B., Zoulim, F., Deny, P., and Stanke, M.

Subjects
Recombination, Genetic, Hepatitis B virus, Internet, Articles, Genome, Viral, Genomics, hepatitis B virus, Sequence Alignment, Markov Chains, Software
Abstract

jpHMM is a very accurate and widely used tool for recombination detection in genomic sequences of HIV-1. Here, we present an extension of jpHMM to analyze recombinations in viruses with circular genomes such as the hepatitis B virus (HBV). Sequence analysis of circular genomes is usually performed on linearized sequences using linear models. Since linear models are unable to model dependencies between nucleotides at the 5′- and 3′-end of a sequence, this can result in inaccurate predictions of recombination breakpoints and thus in incorrect classification of viruses with circular genomes. The proposed circular jpHMM takes into account the circularity of the genome and is not biased against recombination breakpoints close to the 5′- or 3′-end of the linearized version of the circular genome. It can be applied automatically to any query sequence without assuming a specific origin for the sequence coordinates. We apply the method to genomic sequences of HBV and visualize its output in a circular form. jpHMM is available online at http://jphmm.gobics.de for download and as a web server for HIV-1 and HBV sequences. Open-Access-Publikationsfonds 2012 peerReviewed

Published
2012

30. Treatment of SARS with human interferons. (Research letters)

Author

Cinatl, J, Morgenstern, B, Bauer, G, Chandra, P, Rabenau, H, and Doerr, HW

Subjects
Severe acute respiratory syndrome -- Care and treatment, Severe acute respiratory syndrome -- Research, Interferon -- Physiological aspects, Interferon -- Evaluation, Antiviral agents -- Physiological aspects, Antiviral agents -- Evaluation
Published
2003

40. The iBeetle large-scale RNAi screen reveals gene functions for insect development and physiology

Author

Schmitt-Engel, C, Schultheis, D, Schwirz, J, Ströhlein, N, Troelenberg, N, Majumdar, U, Anh Dao, V, Grossmann, D, Ritcher, T, Tech, M, Dönitz, J, Gerischer, L, Theis, M, Schild, I, Trauner, J, Koniszewski, N, Küster, E, Kittelmann, S, Hu, Y, Lehmann, S, Siemanowski, J, Ulrich, J, Panfilio, KA, Schröder, R, Morgenstern, B, Stanke, M, Buchhholz, F, Frasch, M, Roth, S, Wimmer, E, Schoppmeier, M, Kingler, M, Bucher, G, Schmitt-Engel, C, Schultheis, D, Schwirz, J, Ströhlein, N, Troelenberg, N, Majumdar, U, Anh Dao, V, Grossmann, D, Ritcher, T, Tech, M, Dönitz, J, Gerischer, L, Theis, M, Schild, I, Trauner, J, Koniszewski, N, Küster, E, Kittelmann, S, Hu, Y, Lehmann, S, Siemanowski, J, Ulrich, J, Panfilio, KA, Schröder, R, Morgenstern, B, Stanke, M, Buchhholz, F, Frasch, M, Roth, S, Wimmer, E, Schoppmeier, M, Kingler, M, and Bucher, G

Abstract

Genetic screens are powerful tools to identify the genes required for a given biological process. However, for technical reasons, comprehensive screens have been restricted to very few model organisms. Therefore, although deep sequencing is revealing the genes of ever more insect species, the functional studies predominantly focus on candidate genes previously identified in Drosophila, which is biasing research towards conserved gene functions. RNAi screens in other organisms promise to reduce this bias. Here we present the results of the iBeetle screen, a large-scale, unbiased RNAi screen in the red flour beetle, Tribolium castaneum, which identifies gene functions in embryonic and postembryonic development, physiology and cell biology. The utility of Tribolium as a screening platform is demonstrated by the identification of genes involved in insect epithelial adhesion. This work transcends the restrictions of the candidate gene approach and opens fields of research not accessible in Drosophila.

Published
2015

43. Improved phylogenomic taxon sampling noticeably affects non-bilaterian relationships. Molecular Biology and Evolution 27(9): 1983-1987Improved phylogenomic taxon sampling noticeably affects non-bilaterian relationships

Author

Pick, K. S., Philippe, Herve, Schreiber, F., Erpenbeck, D., Jackson, D.J., Wrede, P., Wiens, M., Alié, Alexandre, Morgenstern, B., Manuel, Michaël, Wörheide, G., Systématique, adaptation, évolution (SAE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), and Leballeur, Philippe

Subjects
[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2010

44. Phylogenomics revives traditional views on deep animal relationship

Author

Philippe, H., Romain Derelle, Philippe Lopez, Pick, K., Carole Borchiellini, Nicole Boury-Esnault, Vacelet, J., Emmanuelle Renard, Evelyn Houliston, Eric Quéinnec, Da Silva, C., Winckler, P., Hervé Le Guyader, Leys, S., Jackson, D. J., Schleiber, T., Erpenbeck, D., Morgenstern, B., Wörheide, G., Michaël Manuel, Systématique, adaptation, évolution (SAE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Centre d'océanologie de Marseille (COM), Université de la Méditerranée - Aix-Marseille 2-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Biologie et écologie tropicale et méditerranéenne [2007-2010] (BETM), Université de Perpignan Via Domitia (UPVD)-École pratique des hautes études (EPHE), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2009

45. The genome of the model beetle and pest tribolium castaneum

Author

Richards, S, Gibbs, RA, Weinstock, GM, Brown, SJ, Denell, R, Beeman, RW, Gibbs, R, Bucher, G, Friedrich, M, Grimmelikhuijzen, CJ, Klingler, M, Lorenzen, M, Roth, S, Schröder, R, Tautz, D, Zdobnov, EM, Muzny, D, Attaway, T, Bell, S, Buhay, CJ, Chandrabose, MN, Chavez, D, Clerk-Blankenburg, KP, Cree, A, Dao, M, Davis, C, Chacko, J, Dinh, H, Dugan-Rocha, S, Fowler, G, Garner, TT, Garnes, J, Gnirke, A, Hawes, A, Hernandez, J, Hines, S, Holder, M, Hume, J, Jhangiani, SN, Joshi, V, Khan, ZM, Jackson, L, Kovar, C, Kowis, A, Lee, S, Lewis, LR, Margolis, J, Morgan, M, Nazareth, LV, Nguyen, N, Okwuonu, G, Parker, D, Ruiz, SJ, Santibanez, J, Savard, J, Scherer, SE, Schneider, B, Sodergren, E, Vattahil, S, Villasana, D, White, CS, Wright, R, Park, Y, Lord, J, Oppert, B, Brown, S, Wang, L, Weinstock, G, Liu, Y, Worley, K, Elsik, CG, Reese, JT, Elhaik, E, Landan, G, Graur, D, Arensburger, P, Atkinson, P, Beidler, J, Demuth, JP, Drury, DW, Du, YZ, Fujiwara, H, Maselli, V, Osanai, M, Robertson, HM, Tu, Z, Wang, JJ, Wang, S, Song, H, Zhang, L, Werner, D, Stanke, M, Morgenstern, B, Solovyev, V, Kosarev, P, Brown, G, Chen, HC, Ermolaeva, O, Hlavina, W, Kapustin, Y, Kiryutin, B, Kitts, P, Maglott, D, Pruitt, K, Sapojnikov, V, Souvorov, A, Mackey, AJ, Waterhouse, RM, Wyder, S, Kriventseva, EV, Kadowaki, T, Bork, P, Aranda, M, Bao, R, Beermann, A, Berns, N, Bolognesi, R, Bonneton, F, Bopp, D, Butts, T, Chaumot, A, Denell, RE, Ferrier, DE, Gordon, CM, Jindra, M, Lan, Q, Lattorff, HM, Laudet, V, von Levetsow, C, Liu, Z, Lutz, R, Lynch, JA, da Fonseca, RN, Posnien, N, Reuter, R, Schinko, JB, Schmitt, C, Schoppmeier, M, Shippy, TD, Simonnet, F, Marques-Souza, H, Tomoyasu, Y, Trauner, J, Van der Zee, M, Vervoort, M, Wittkopp, N, Wimmer, EA, Yang, X, Jones, AK, Sattelle, DB, Ebert, PR, Nelson, D, Scott, JG, Muthukrishnan, S, Kramer, KJ, Arakane, Y, Zhu, Q, Hogenkamp, D, Dixit, R, Jiang, H, Zou, Z, Marshall, J, Elpidina, E, Vinokurov, K, Oppert, C, Evans, J, Lu, Z, Zhao, P, Sumathipala, N, Altincicek, B, Vilcinskas, A, Williams, M, Hultmark, D, Hetru, C, Hauser, F, Cazzamali, G, Williamson, M, Li, B, Tanaka, Y, Predel, R, Neupert, S, Schachtner, J, Verleyen, P, Raible, F, Walden, KK, Angeli, S, Forêt, S, Schuetz, S, Maleszka, R, Miller, SC, Grossmann, D, MDC Library, and Zdobnov, Evgeny

Subjects
0106 biological sciences, Repetitive Sequences, Nucleic Acid/genetics, Insecticides, Proteome, Genome, Insect, Cytochrome P-450 Enzyme System/genetics, Genes, Insect, Insect, Receptors, Odorant, 01 natural sciences, Genome, Receptors, G-Protein-Coupled, G-Protein-Coupled Receptors, Genome, Insect/ genetics, Oogenesis, Cytochrome P-450 Enzyme System, RNA interference, Odorant Receptors, Caenorhabditis elegans, Insect Genome, Phylogeny, media_common, Genetics, ddc:616, 0303 health sciences, Base Composition, Neurotransmitter Agents, Tribolium, Multidisciplinary, Neurotransmitter Agents/genetics, Receptors, Odorant/genetics, Vision, Ocular/genetics, Telomere, Insecticides/pharmacology, DNA Transposable Elements/genetics, Proteome/genetics, Genes, Insect/ genetics, Oogenesis/genetics, Taste, RNA Interference, Growth and Development, Drosophila melanogaster, animal structures, Nucleic Acid Repetitive Sequences, Taste/genetics, media_common.quotation_subject, 570 Life Sciences, Biology, 010603 evolutionary biology, 610 Medical Sciences, Medicine, 03 medical and health sciences, Humans, Insect Genes, Ocular Vision, Animals, Tribolium/classification/embryology/ genetics/physiology, Red flour beetle, Gene, Drosophila, Vision, Ocular, 030304 developmental biology, Repetitive Sequences, Nucleic Acid, Growth and Development/genetics, Telomere/genetics, Body Patterning, fungi, biology.organism_classification, Body Patterning/genetics, Cardiovascular and Metabolic Diseases, DNA Transposable Elements, Receptors, G-Protein-Coupled/genetics
Abstract

Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved the ability to interact with a diverse chemical environment, as shown by large expansions in odorant and gustatory receptors, as well as P450 and other detoxification enzymes. Development in Tribolium is more representative of other insects than is Drosophila, a fact reflected in gene content and function. For example, Tribolium has retained more ancestral genes involved in cell-cell communication than Drosophila, some being expressed in the growth zone crucial for axial elongation in short-germ development. Systemic RNA interference in T. castaneum functions differently from that in Caenorhabditis elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control.

Published
2008

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