6,754 results on '"Morgan, G"'
Search Results
2. The Beta-decay Paul Trap Mk IV: Design and commissioning
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Varriano, L., Savard, G., Clark, J. A., Burdette, D. P., Burkey, M. T., Gallant, A. T., Hirsh, T. Y., Longfellow, B., Scielzo, N. D., Segel, R., Boron III, E. J., Brodeur, M., Callahan, N., Cannon, A., Kolos, K., Liu, B., Lopez-Caceres, S., Gott, M., Maaß, B., Marley, S. T., Mohs, C., Morgan, G. E., Mueller, P., Oberling, M., O'Malley, P. D., Porter, W. S., Purcell, Z., Ray, D., Rivero, F., Valverde, A. A., Wilson, G. L., and Zite, R.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
The Beta-decay Paul Trap is an open-geometry, linear trap used to measure the decays of $^8$Li and $^8$B to search for a tensor contribution to the weak interaction. In the latest $^8$Li measurement of Burkey et al. (2022), $\beta$ scattering was the dominant experimental systematic uncertainty. The Beta-decay Paul Trap Mk IV reduces the prevalence of $\beta$ scattering by a factor of 4 through a redesigned electrode geometry and the use of glassy carbon and graphite as electrode materials. The trap has been constructed and successfully commissioned with $^8$Li in a new data campaign that collected 2.6 million triple coincidence events, an increase in statistics by 30% with 4 times less $\beta$ scattering compared to the previous $^8$Li data set., Comment: 17 pages, 7 figures
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- 2023
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3. Plasmon Fizeau drag in 3D Dirac and Weyl semimetals
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Blevins, Morgan G. and Boriskina, Svetlana V.
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Condensed Matter - Mesoscale and Nanoscale Physics ,Physics - Optics - Abstract
There is a need for compact, dynamically tunable nonreciprocal optical elements to enable on-chip-compatible optical isolators and more efficient radiative energy transfer systems. Plasmon Fizeau drag, the drag of electrical current on propagating surface plasmon polaritons, has been proposed to induce nonreciprocal surface modes to enable one-way energy transport. However, relativistic electron drift velocities are required to induce appreciable contrast between the dispersion characteristics of co-propagating and counter-propagating surface plasmon modes. The high electron drift velocity of graphene previously allowed for the experimental demonstration of current-induced nonreciprocity in a two-dimensional (2D) Dirac material. The high electron drift and Fermi velocities in three-dimensional (3D) Dirac materials make them ideal candidates for the effect, however, both the theory of the Fizeau drag effect and its experimental demonstrations in 3D Dirac materials are missing. Here we develop a comprehensive theory of Fizeau drag in DC-biased 3D Weyl semimetals (WSM) or Dirac semimetals (DSM), both under local and non-local approximation and with dissipative losses. We predict that under practical assumptions for loss, Fizeau drag in the DSM Cd$_3$As$_2$ opens windows of pseudo-unidirectional transport. We additionally introduce new figures of merit to rank nonreciprocal plasmonic systems by their potential for directional SPP transport. Further, we propose a new approach for achieving appreciable plasmonic Fizeau drag via optically pumping bulk inversion symmetry breaking WSMs or DSMs.
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- 2023
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4. Expert review of the science underlying nature-based climate solutions
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Buma, B., Gordon, D. R., Kleisner, K. M., Bartuska, A., Bidlack, A., DeFries, R., Ellis, P., Friedlingstein, P., Metzger, S., Morgan, G., Novick, K., Sanchirico, J. N., Collins, J. R., Eagle, A. J., Fujita, R., Holst, E., Lavallee, J. M., Lubowski, R. N., Melikov, C., Moore, L. A., Oldfield, E. E., Paltseva, J., Raffeld, A. M., Randazzo, N. A., Schneider, C., Uludere Aragon, N., and Hamburg, S. P.
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- 2024
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5. Large Synthetic Data from the arXiv for OCR Post Correction of Historic Scientific Articles
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Naiman, Jill P., Cosillo, Morgan G., Williams, Peter K. G., and Goodman, Alyssa
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Computer Science - Digital Libraries ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Scientific articles published prior to the "age of digitization" (~1997) require Optical Character Recognition (OCR) to transform scanned documents into machine-readable text, a process that often produces errors. We develop a pipeline for the generation of a synthetic ground truth/OCR dataset to correct the OCR results of the astrophysics literature holdings of the NASA Astrophysics Data System (ADS). By mining the arXiv we create, to the authors' knowledge, the largest scientific synthetic ground truth/OCR post correction dataset of 203,354,393 character pairs. We provide baseline models trained with this dataset and find the mean improvement in character and word error rates of 7.71% and 18.82% for historical OCR text, respectively. When used to classify parts of sentences as inline math, we find a classification F1 score of 77.82%. Interactive dashboards to explore the dataset are available online: https://readingtimemachine.github.io/projects/1-ocr-groundtruth-may2023, and data and code, within the limitations of our agreement with the arXiv, are hosted on GitHub: https://github.com/ReadingTimeMachine/ocr_post_correction., Comment: 6 pages, 1 figure, 1 table; training/validation/test datasets and all model weights to be linked on Zenodo on publication
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- 2023
6. Executive Summary of the Topical Program: Nuclear Isomers in the Era of FRIB
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Misch, G. W., Mumpower, M. R., Kondev, F. G., Marley, S. T., Almaraz-Calderon, S., Brodeur, M., Brown, B. A., Carpenter, M. P., Carroll, J. J., Chiara, C. J., Chipps, K. A., Crider, B. P., Gade, A., Grzywacz, R., Jones, K. L., Kay, B. P., Kolos, K., Litvinov, Yu. A., Lopez-Caceres, S., Meyer, B. S., Minamisono, K., Morgan, G. E., Orford, R., Pain, S. D., Purcell, J., Ratkiewicz, A., Schatz, H., Sprouse, T. M., Sun, Y., Surman, R., Tannous, J. A., and Walker, P. M.
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Nuclear Theory ,Nuclear Experiment - Abstract
We report on the Facility for Rare Isotope Beams (FRIB) Theory Alliance topical program "Nuclear Isomers in the Era of FRIB". We outline the many ways isomers influence and contribute to nuclear science and technology, especially in the four FRIB pillars: properties of rare isotopes, nuclear astrophysics, fundamental symmetries, and applications for the nation and society. We conclude with a resolution stating our recommendation that the nuclear physics community actively pursue isomer research. A white paper is forthcoming., Comment: 4 pages including references
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- 2023
7. A Playbook to be Proud of: Making the Case for LGBTQ+ Inclusive User Account Design.
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Beatrice Fadrigon, Princess Gordon, Jane Lupica, and Morgan G. Ames
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- 2024
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8. Correction: Exploring the microbiome of oral epithelial dysplasia as a predictor of malignant progression
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Wright, Robyn J., Pewarchuk, Michelle E., Marshall, Erin A., Murray, Benjamin, Rosin, Miriam P., Laronde, Denise M., Zhang, Lewei, Lam, Wan L., Langille, Morgan G. I., and Rock, Leigha D.
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- 2024
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9. Oral microbial signatures associated with age and frailty in Canadian adults
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DeClercq, Vanessa, Wright, Robyn J., Nearing, Jacob T., and Langille, Morgan G. I.
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- 2024
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10. Interrogation of the human cortical peptidome uncovers cell-type specific signatures of cognitive resilience against Alzheimer’s disease
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Morgan, G. R. and Carlyle, B. C.
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- 2024
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11. Progression free survival of myeloma patients who become IFE-negative correlates with the detection of residual monoclonal free light chain (FLC) by mass spectrometry
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Giles, H. V., Drayson, M. T., Kishore, B., Pawlyn, C., Kaiser, M., Cook, G., de Tute, R., Owen, R. G., Cairns, D., Menzies, T., Davies, F. E., Morgan, G. J., Pratt, G., and Jackson, G. H.
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- 2024
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12. Cross-study analyses of microbial abundance using generalized common factor methods
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Hayes, Molly G., Langille, Morgan G. I., and Gu, Hong
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Statistics - Applications ,62P10 - Abstract
By creating networks of biochemical pathways, communities of micro-organisms are able to modulate the properties of their environment and even the metabolic processes within their hosts. Next-generation high-throughput sequencing has led to a new frontier in microbial ecology, promising the ability to leverage the microbiome to make crucial advancements in the environmental and biomedical sciences. However, this is challenging, as genomic data are high-dimensional, sparse, and noisy. Much of this noise reflects the exact conditions under which sequencing took place, and is so significant that it limits consensus-based validation of study results. We propose an ensemble approach for cross-study exploratory analyses of microbial abundance data in which we first estimate the variance-covariance matrix of the underlying abundances from each dataset on the log scale assuming Poisson sampling, and subsequently model these covariances jointly so as to find a shared low-dimensional subspace of the feature space. By viewing the projection of the latent true abundances onto this common structure, the variation is pared down to that which is shared among all datasets, and is likely to reflect more generalizable biological signal than can be inferred from individual datasets. We investigate several ways of achieving this, and demonstrate that they work well on simulated and real metagenomic data in terms of signal retention and interpretability.
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- 2023
13. Novel Tetrazolium-Based Colorimetric Assay for Helicase nsp13 in SARS-CoV-2
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Triet M. Pham, Morgan G. Howard, Shane M. Carey, Lindsey R. Baker, and Edward L. D’Antonio
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SARS-CoV-2 ,COVID-19 ,nsp13 ,helicase ,absorbance-based assay ,INT ,Therapeutics. Pharmacology ,RM1-950 ,Biochemistry ,QD415-436 - Abstract
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a human pathogenic virus that encodes for a helicase (SC2Hel) that is essential for viral replication. SC2Hel has the ability to unravel dsRNA or dsDNA in an NTP-dependent manner from the 5′ to 3′ directionality. The standard helicase assay from studies involving SARS-CoV and SARS-CoV-2 have relied on the concept of fluorescence resonance energy transfer. Adding to the collection of helicase assays, herein, we have developed a novel tetrazolium-based colorimetric assay system for the detection of ADP that is produced via SC2Hel activity. This SC2Hel assay combines three enzyme-coupled steps involving the ADP-dependent Thermococcus litoralis glucokinase (TlGlcK), Leuconostoc mesenteroides glucose-6-phosphate dehydrogenase (LmG6PDH), and Clostridium kluyveri diaphorase (CkDIA). Iodonitrotetrazolium chloride (INT), a colorimetric tetrazolium reagent, was used in the final step of the assay that converted into INT-formazan during reduction. INT-formazan in the assay’s buffered solution at pH 7.6 exhibited an intense colorimetric response at a wavelength maximum of 505 nm. The assay exhibited excellent performance characteristics as it revealed a Z’ factor of 0.87 and it has the potential to be further adopted into high-throughput screening studies for therapeutic drug discovery research.
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- 2024
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14. Oral microbial signatures associated with age and frailty in Canadian adults
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Vanessa DeClercq, Robyn J. Wright, Jacob T. Nearing, and Morgan G. I. Langille
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Medicine ,Science - Abstract
Abstract This study aimed to assess the association between the oral microbiome, age, and frailty. Data and saliva samples were obtained from male and female participants aged 35–70 years (n = 1357). Saliva samples were analysed by 16S rRNA gene sequencing and differences in microbial diversity and community compositions were examined in relation to chronological age and the frailty index (FI). Most alpha diversity measures (Richness, Shannon Diversity, Faith’s Phylogenetic Diversity) showed an inverse association with frailty, whereas a positive association was observed with age and Shannon Diversity and Evenness. A further sex-stratified analysis revealed differences in measures of microbial diversity and composition. Multiple genera were detected as significantly differentially abundant with increasing frailty and age by at least two methods. With age, the relative abundance of Veillonella was reduced in both males and females, whereas increases in Corynebacterium appeared specific to males and Aggregatibacter, Fusobacterium, Neisseria, Stomatobaculum, and Porphyromonas specific to females. Beta diversity was significantly associated with multiple mental health components of the FI. This study shows age and frailty are differentially associated with measures of microbial diversity and composition, suggesting the oral microbiome may be a useful indicator of increased risk of frailty or a potential target for improving health in ageing adults.
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- 2024
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15. Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
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Jean-Louis A. Parmasad, Konrad M. Ricke, Benjamin Nguyen, Morgan G. Stykel, Brodie Buchner-Duby, Amanda Bruce, Haley M. Geertsma, Eric Lian, Nathalie A. Lengacher, Steve M. Callaghan, Alvin Joselin, Julianna J. Tomlinson, Michael G. Schlossmacher, William L. Stanford, Jiyan Ma, Patrik Brundin, Scott D. Ryan, and Maxime W. C. Rousseaux
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Cytology ,QH573-671 - Abstract
Abstract Parkinson’s disease (PD) is a debilitating neurodegenerative disease characterized by the loss of midbrain dopaminergic neurons (DaNs) and the abnormal accumulation of α-Synuclein (α-Syn) protein. Currently, no treatment can slow nor halt the progression of PD. Multiplications and mutations of the α-Syn gene (SNCA) cause PD-associated syndromes and animal models that overexpress α-Syn replicate several features of PD. Decreasing total α-Syn levels, therefore, is an attractive approach to slow down neurodegeneration in patients with synucleinopathy. We previously performed a genetic screen for modifiers of α-Syn levels and identified CDK14, a kinase of largely unknown function as a regulator of α-Syn. To test the potential therapeutic effects of CDK14 reduction in PD, we ablated Cdk14 in the α-Syn preformed fibrils (PFF)-induced PD mouse model. We found that loss of Cdk14 mitigates the grip strength deficit of PFF-treated mice and ameliorates PFF-induced cortical α-Syn pathology, indicated by reduced numbers of pS129 α-Syn-containing cells. In primary neurons, we found that Cdk14 depletion protects against the propagation of toxic α-Syn species. We further validated these findings on pS129 α-Syn levels in PD patient neurons. Finally, we leveraged the recent discovery of a covalent inhibitor of CDK14 to determine whether this target is pharmacologically tractable in vitro and in vivo. We found that CDK14 inhibition decreases total and pathologically aggregated α-Syn in human neurons, in PFF-challenged rat neurons and in the brains of α-Syn-humanized mice. In summary, we suggest that CDK14 represents a novel therapeutic target for PD-associated synucleinopathy.
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- 2024
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16. Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
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Parmasad, Jean-Louis A., Ricke, Konrad M., Nguyen, Benjamin, Stykel, Morgan G., Buchner-Duby, Brodie, Bruce, Amanda, Geertsma, Haley M., Lian, Eric, Lengacher, Nathalie A., Callaghan, Steve M., Joselin, Alvin, Tomlinson, Julianna J., Schlossmacher, Michael G., Stanford, William L., Ma, Jiyan, Brundin, Patrik, Ryan, Scott D., and Rousseaux, Maxime W. C.
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- 2024
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17. Self-regulation training generalizability using the regulation of craving task. An fMRI study
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Iriannys Torres Morillo, Marcia Smith Pasqualini, Morgan G. Brucks, and Laura E. Martin
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self-regulation ,food craving ,brain activation ,addiction ,fMRI ,Psychology ,BF1-990 - Abstract
Individual differences in reward salience may relate to the difficulty in regulating the effects of multiple substances (e.g., nicotine and food). Increased brain activation in reward and self-regulation (SR) regions has been evidenced while adults view appetitive cues (e.g., food pictures) to test substance use disorder treatment response. Enhancing SR with behavioral interventions may increase brain activation in SR regions and reduce responses in reward regions. Our primary analysis demonstrated increased brain activation in SR regions to smoking cues among individuals who practiced SR by delaying their first cigarette of the day for 2 weeks. However, little is known about the generalizability of SR between appetitive cues. This secondary analysis explored the influence of adherence to a SR behavioral intervention by examining the impact of practicing smoking SR on brain activation to food cues among adults who smoke. Participants (N = 65) were randomly assigned to practice SR by delaying their first daily cigarette or smoking as usual for 2-weeks. Functional magnetic resonance imaging data were collected while people were told to think of “negative” or “positive” associations with the cue. The results indicated that practicing smoking SR was linked with increased activation in the dorsolateral prefrontal cortex (dlPFC) when viewing food cues. There was no correlation between delaying smoking adherence and brain activation in the dlPFC. Exploratory analyses suggested higher dlPFC activation when people thought about “positive” associations with the food cues instead of “negative” ones. We concluded that practicing smoking SR is related to increased brain activation to food cues, suggesting potential generalizability of SR practice from smoking cues to food cues.
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- 2024
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18. Improved Limit on Tensor Currents in the Weak Interaction from $^8$Li $\beta$ Decay
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Burkey, M. T., Savard, G., Gallant, A. T., Scielzo, N. D., Hirsh, T. Y., Varriano, L., Sargsyan, G. H., Launey, K. D., Brodeur, M., Burdette, D. P., Heckmaier, E., Joerres, K., Klimes, J. W., Kolos, K., Laminack, A., Leach, K. G., Levand, A. F., Longfellow, B., Maaß, B., Marley, S. T., Morgan, G. E., Mueller, P., Orford, R., Padgett, S. W., Galván, A. Pérez, Pierce, J. R., Ray, D., Segel, R., Siegl, K., Sharma, K. S., and Wang, B. S.
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Nuclear Experiment ,High Energy Physics - Phenomenology ,Nuclear Theory - Abstract
The electroweak interaction in the Standard Model (SM) is described by a pure vector-axial-vector structure, though any Lorentz-invariant component could contribute. In this work, we present the most precise measurement of tensor currents in the low-energy regime by examining the $\beta$-$\bar{\nu}$ correlation of trapped $^{8}$Li ions with the Beta-decay Paul Trap. We find $a_{\beta\nu} = -0.3325 \pm 0.0013_{stat} \pm 0.0019_{syst}$ at $1\sigma$ for the case of coupling to right-handed neutrinos $(C_T=-C_T')$, which is consistent with the SM prediction., Comment: 6 pages, 3 figures, 1 table
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- 2022
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19. Discovery of the new isotope Lr251: Impact of the hexacontetrapole deformation on single-proton orbital energies near the Z=100 deformed shell gap
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Huang, T, Seweryniak, D, Back, BB, Bender, PC, Carpenter, MP, Chowdhury, P, Clark, RM, Copp, PA, He, X-T, Herzberg, RD, Hoff, DEM, Jayatissa, H, Khoo, TL, Kondev, FG, Morgan, G, Morse, C, Korichi, A, Lauritsen, T, Müller-Gatermann, C, Potterveld, DH, Reviol, W, Rogers, AM, Saha, S, Savard, G, Sharma, K, Stolze, S, Waniganeththi, S, Wilson, GL, Wu, J, Xu, Y-F, and Zhu, S
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Nuclear and Plasma Physics ,Synchrotrons and Accelerators ,Physical Sciences ,Nuclear and plasma physics - Abstract
The products of the Tl203,205(Ti50,2n) fusion-evaporation reactions were studied using the recently commissioned Argonne Gas-Filled Analyzer at Argonne National Laboratory. Two α-decay activities with energies of 9210(19) and 9246(19) keV and half-lives of 42-14+42 and 24.4-4.5+7.0 ms were observed which were followed by the known α decays of Md247 and Es243. They are interpreted as originating from the 1/2-[521] and 7/2-[514] single-proton Nilsson states in the hitherto unknown isotope Lr251. From the measured Qα values the 1/2- level was placed 117(27) keV above the 7/2- level in Lr251 in contrast to Lr255 where the 1/2- level is the lowest. Also, the α decay of Lr253 was studied in more detail and a new α line at 8660(20) keV was found and a new half-life value of 2.46(32) s for an isomeric state in Lr253 was measured. The Lr251,253,255Qα values were compared with predictions of various mass models. The relative energies of the 1/2-[521] and 7/2-[514] single-proton Nilsson states in Lr251,253,255 isotopes were compared with results of the cranking shell model with pairing treated using the particle-number-conserving method. The level separation and, in particular, the level order change between Lr251 and Lr255 was reproduced only when the hexacontetrapole deformation 6 was included in the calculations.
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- 2022
20. Microbial hitchhikers harbouring antimicrobial-resistance genes in the riverine plastisphere
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Vinko Zadjelovic, Robyn J. Wright, Chiara Borsetto, Jeannelle Quartey, Tyler N. Cairns, Morgan G. I. Langille, Elizabeth M. H. Wellington, and Joseph A. Christie-Oleza
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Microbial ecology ,QR100-130 - Abstract
Abstract Background The widespread nature of plastic pollution has given rise to wide scientific and social concern regarding the capacity of these materials to serve as vectors for pathogenic bacteria and reservoirs for Antimicrobial Resistance Genes (ARG). In- and ex-situ incubations were used to characterise the riverine plastisphere taxonomically and functionally in order to determine whether antibiotics within the water influenced the ARG profiles in these microbiomes and how these compared to those on natural surfaces such as wood and their planktonic counterparts. Results We show that plastics support a taxonomically distinct microbiome containing potential pathogens and ARGs. While the plastisphere was similar to those biofilms that grew on wood, they were distinct from the surrounding water microbiome. Hence, whilst potential opportunistic pathogens (i.e. Pseudomonas aeruginosa, Acinetobacter and Aeromonas) and ARG subtypes (i.e. those that confer resistance to macrolides/lincosamides, rifamycin, sulfonamides, disinfecting agents and glycopeptides) were predominant in all surface-related microbiomes, especially on weathered plastics, a completely different set of potential pathogens (i.e. Escherichia, Salmonella, Klebsiella and Streptococcus) and ARGs (i.e. aminoglycosides, tetracycline, aminocoumarin, fluoroquinolones, nitroimidazole, oxazolidinone and fosfomycin) dominated in the planktonic compartment. Our genome-centric analysis allowed the assembly of 215 Metagenome Assembled Genomes (MAGs), linking ARGs and other virulence-related genes to their host. Interestingly, a MAG belonging to Escherichia –that clearly predominated in water– harboured more ARGs and virulence factors than any other MAG, emphasising the potential virulent nature of these pathogenic-related groups. Finally, ex-situ incubations using environmentally-relevant concentrations of antibiotics increased the prevalence of their corresponding ARGs, but different riverine compartments –including plastispheres– were affected differently by each antibiotic. Conclusions Our results provide insights into the capacity of the riverine plastisphere to harbour a distinct set of potentially pathogenic bacteria and function as a reservoir of ARGs. The environmental impact that plastics pose if they act as a reservoir for either pathogenic bacteria or ARGs is aggravated by the persistence of plastics in the environment due to their recalcitrance and buoyancy. Nevertheless, the high similarities with microbiomes growing on natural co-occurring materials and even more worrisome microbiome observed in the surrounding water highlights the urgent need to integrate the analysis of all environmental compartments when assessing risks and exposure to pathogens and ARGs in anthropogenically-impacted ecosystems. Video Abstract
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- 2023
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21. Cross-study analyses of microbial abundance using generalized common factor methods
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Molly G. Hayes, Morgan G. I. Langille, and Hong Gu
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Cross-study analysis ,Microbiome ,Multi-group analysis ,Common principal components ,Common factor models ,Ensemble principal component analysis ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Biology (General) ,QH301-705.5 - Abstract
Abstract Background By creating networks of biochemical pathways, communities of micro-organisms are able to modulate the properties of their environment and even the metabolic processes within their hosts. Next-generation high-throughput sequencing has led to a new frontier in microbial ecology, promising the ability to leverage the microbiome to make crucial advancements in the environmental and biomedical sciences. However, this is challenging, as genomic data are high-dimensional, sparse, and noisy. Much of this noise reflects the exact conditions under which sequencing took place, and is so significant that it limits consensus-based validation of study results. Results We propose an ensemble approach for cross-study exploratory analyses of microbial abundance data in which we first estimate the variance-covariance matrix of the underlying abundances from each dataset on the log scale assuming Poisson sampling, and subsequently model these covariances jointly so as to find a shared low-dimensional subspace of the feature space. Conclusions By viewing the projection of the latent true abundances onto this common structure, the variation is pared down to that which is shared among all datasets, and is likely to reflect more generalizable biological signal than can be inferred from individual datasets. We investigate several ways of achieving this, demonstrate that they work well on simulated and real metagenomic data in terms of signal retention and interpretability, and recommend a particular implementation.
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- 2023
- Full Text
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22. Child Opportunity Index and Pediatric Intensive Care Outcomes: A Multicenter Retrospective Study in the United States*
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McCrory, Michael C., Akande, Manzilat, Slain, Katherine N., Kennedy, Curtis E., Winter, Meredith C., Stottlemyre, Morgan G., Wakeham, Martin K., Barnack, Kyle A., Huang, Jia Xin, Sharma, Meesha, Zurca, Adrian D., Pinto, Neethi P., Dziorny, Adam C., Maddux, Aline B., Garg, Anjali, Woodruff, Alan G., Hartman, Mary E., Timmons, Otwell D., Heidersbach, R. Scott, Cisco, Michael J., Sochet, Anthony A., Wells, Brian J., Halvorson, Elizabeth E., and Saha, Amit K.
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- 2024
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23. Correction: Exploring the microbiome of oral epithelial dysplasia as a predictor of malignant progression
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Robyn J. Wright, Michelle E. Pewarchuk, Erin A. Marshall, Benjamin Murray, Miriam P. Rosin, Denise M. Laronde, Lewei Zhang, Wan L. Lam, Morgan G. I. Langille, and Leigha D. Rock
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Dentistry ,RK1-715 - Published
- 2024
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24. Network analysis of S-nitrosylated synaptic proteins demonstrates unique roles in health and disease
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Stykel, Morgan G. and Ryan, Scott D.
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- 2024
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25. Microbial hitchhikers harbouring antimicrobial-resistance genes in the riverine plastisphere
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Zadjelovic, Vinko, Wright, Robyn J., Borsetto, Chiara, Quartey, Jeannelle, Cairns, Tyler N., Langille, Morgan G. I., Wellington, Elizabeth M. H., and Christie-Oleza, Joseph A.
- Published
- 2023
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26. Investigating the oral microbiome in retrospective and prospective cases of prostate, colon, and breast cancer
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Nearing, Jacob T., DeClercq, Vanessa, and Langille, Morgan G. I.
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- 2023
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27. Exploring the microbiome of oral epithelial dysplasia as a predictor of malignant progression
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Wright, Robyn J., Pewarchuk, Michelle E., Marshall, Erin A., Murrary, Benjamin, Rosin, Miriam P., Laronde, Denise M., Zhang, Lewei, Lam, Wan L., Langille, Morgan G. I., and Rock, Leigha D.
- Published
- 2023
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28. Large Synthetic Data from the arχiv for OCR Post Correction of Historic Scientific Articles.
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Jill P. Naiman, Morgan G. Cosillo, Peter K. G. Williams, and Alyssa Goodman
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- 2023
- Full Text
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29. Large Synthetic Data from the ariv for OCR Post Correction of Historic Scientific Articles
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Naiman, J. P., Cosillo, Morgan G., Williams, Peter K. G., Goodman, Alyssa, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Alonso, Omar, editor, Cousijn, Helena, editor, Silvello, Gianmaria, editor, Marrero, Mónica, editor, Teixeira Lopes, Carla, editor, and Marchesin, Stefano, editor
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- 2023
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30. New Classification for Pediatric Proximal Fifth Metatarsal Fractures
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Lee, Hannah A., Batley, Morgan G., Krakow, Arielle, Buczek, Matthew J., Sarkar, Sulagna, Talwar, Divya, Horn, Bernard David, and Davidson, Richard S.
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- 2024
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31. Air pollution mortality benefits of sustained COVID-19 mobility restrictions in Australian cities
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Chaston, T.B., Knibbs, L.D., Morgan, G., Jalaludin, B., Broome, R., Dennekamp, M., Johnston, F.H., and Vardoulakis, S.
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- 2024
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32. Exploration of Potential Broad-Spectrum Antiviral Targets in the Enterovirus Replication Element: Identification of Six Distinct 5′ Cloverleaves
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Morgan G. Daniels, Meagan E. Werner, Rockwell T. Li, and Steven M. Pascal
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RNA ,enterovirus ,picornavirus ,cloverleaf ,replication ,Microbiology ,QR1-502 - Abstract
Enterovirus genomic replication initiates at a predicted RNA cloverleaf (5′CL) at the 5′ end of the RNA genome. The 5′CL contains one stem (SA) and three stem-loops (SLB, SLC, SLD). Here, we present an analysis of 5′CL conservation and divergence for 209 human health-related serotypes from the enterovirus genus, including enterovirus and rhinovirus species. Phylogenetic analysis indicates six distinct 5′CL serotypes that only partially correlate with the species definition. Additional findings include that 5′CL sequence conservation is higher between the EV species than between the RV species, the 5′CL of EVA and EVB are nearly identical, and RVC has the lowest 5′CL conservation. Regions of high conservation throughout all species include SA and the loop and nearby bases of SLB, which is consistent with known protein interactions at these sites. In addition to the known protein binding site for the Poly-C binding protein in the loop of SLB, other conserved consecutive cytosines in the stems of SLB and SLC provide additional potential interaction sites that have not yet been explored. Other sites of conservation, including the predicted bulge of SLD and other conserved stem, loop, and junction regions, are more difficult to explain and suggest additional interactions or structural requirements that are not yet fully understood. This more intricate understanding of sequence and structure conservation and variability in the 5′CL may assist in the development of broad-spectrum antivirals against a wide range of enteroviruses, while better defining the range of virus isotypes expected to be affected by a particular antiviral.
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- 2024
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33. Investigating the oral microbiome in retrospective and prospective cases of prostate, colon, and breast cancer
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Jacob T. Nearing, Vanessa DeClercq, and Morgan G. I. Langille
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Microbial ecology ,QR100-130 - Abstract
Abstract The human microbiome has been proposed as a potentially useful biomarker for several cancers. To examine this, we made use of salivary samples from the Atlantic Partnership for Tomorrow’s Health (PATH) project and Alberta’s Tomorrow Project (ATP). Sample selection was divided into both a retrospective and prospective case control design examining prostate, breast, and colon cancer. In total 89 retrospective and 260 prospective cancer cases were matched to non-cancer controls and saliva samples were sequenced using 16S rRNA gene sequencing. We found no significant differences in alpha diversity. All beta diversity measures were insignificant except for unweighted UniFrac profiles in retrospective breast cancer cases and weighted UniFrac, Bray-Curtis and Robust Atchinson’s distances in colon cancer after testing with age and sex adjusted MiRKAT models. Differential abundance (DA) analysis showed several taxa that were associated with previous cancer in all three groupings. Only one genus (Clostridia UCG-014) in breast cancer and one ASV (Fusobacterium periodonticum) in colon cancer was identified by more than one DA tool. In prospective cases three ASVs were associated with colon cancer, one ASV with breast cancer, and one ASV with prostate cancer. Random Forest classification showed low levels of signal in both study designs in breast and prostate cancer. Contrastingly, colon cancer did show signal in our retrospective analysis (AUC: 0.737) and in one of two prospective cohorts (AUC: 0.717). Our results indicate that it is unlikely that reliable microbial oral biomarkers for breast and prostate cancer exist.. However, further research into the oral microbiome and colon cancer could be fruitful.
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- 2023
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34. Exploring the microbiome of oral epithelial dysplasia as a predictor of malignant progression
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Robyn J. Wright, Michelle E. Pewarchuk, Erin A. Marshall, Benjamin Murrary, Miriam P. Rosin, Denise M. Laronde, Lewei Zhang, Wan L. Lam, Morgan G. I. Langille, and Leigha D. Rock
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Oral epithelial dysplasia ,Oral cancer ,16S rRNA sequencing ,Oral microbiota ,Microbiome ,Dentistry ,RK1-715 - Abstract
Abstract A growing body of research associates the oral microbiome and oral cancer. Well-characterized clinical samples with outcome data are required to establish relevant associations between the microbiota and disease. The objective of this study was to characterize the community variations and the functional implications of the microbiome in low-grade oral epithelial dysplasia (OED) using 16S rRNA gene sequencing from annotated archival swabs in progressing (P) and non-progressing (NP) OED. We characterised the microbial community in 90 OED samples — 30 swabs from low-grade OED that progressed to cancer (cases) and 60 swabs from low-grade OED that did not progress after a minimum of 5 years of follow up (matched control subjects). There were small but significant differences between P and NP samples in terms of alpha diversity as well as beta diversity in conjunction with other clinical factors such as age and smoking status for both taxa and functional predictions. Across all samples, the most abundant genus was Streptococcus, followed by Haemophilus, Rothia, and Neisseria. Taxa and predicted functions were identified that were significantly differentially abundant with progression status (all Ps and NPs), when samples were grouped broadly by the number of years between sampling and progression or in specific time to progression for Ps only. However, these differentially abundant features were typically present only at low abundances. For example, Campylobacter was present in slightly higher abundance in Ps (1.72%) than NPs (1.41%) and this difference was significant when Ps were grouped by time to progression. Furthermore, several of the significantly differentially abundant functions were linked to the Campylobacteraceae family in Ps and may justify further investigation. Larger cohort studies to further explore the microbiome as a potential biomarker of risk in OED are warranted.
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- 2023
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35. TurboPy: A Lightweight Python Framework for Computational Physics
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Richardson, A. S., Gordon, D. F., Swanekamp, S. B., Rittersdorf, I. M., Adamson, P. E., Grannis, O. S., Morgan, G. T., Ostenfeld, A., Phlips, K. L., Sun, C. G., Tang, G., and Watkins, D. J.
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Physics - Computational Physics ,Physics - Plasma Physics - Abstract
Computational physics problems often have a common set of aspects to them that any particular numerical code will have to address. Because these aspects are common to many problems, having a framework already designed and ready to use will not only speed the development of new codes, but also enhance compatibility between codes. Some of the most common aspects of computational physics problems are: a grid, a clock which tracks the flow of the simulation, and a set of models describing the dynamics of various quantities on the grid. Having a framework that could deal with these basic aspects of the simulation in a common way could provide great value to computational scientists by solving various numerical and class design issues that routinely arise. This paper describes the newly developed computational framework that we have built for rapidly prototyping new physics codes. This framework, called turboPy, is a lightweight physics modeling framework based on the design of the particle-in-cell code turboWAVE. It implements a class (called Simulation) which drives the simulation and manages communication between physics modules, a class (called PhysicsModule) which handles the details of the dynamics of the various parts of the problem, and some additional classes such as a Grid class and a Diagnostic class to handle various ancillary issues that commonly arise.
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- 2020
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36. Deer management influences perception of avian plumage in temperate deciduous forests
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Boycott, Timothy J., Sherrard, Morgan G., Gall, Megan D., and Ronald, Kelly L.
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- 2023
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37. Regulations or delegations? : how Congress delegated its war powers to the President through discretionary AUMFs
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Baker, Morgan G.
- Abstract
My thesis examines the expansion of U.S. presidential war power, under the lens of congressionally enacted authorizations for use of military force (AUMFs), since the founding. Whereas most academic scholarship has been dedicated to unauthorized presidential war making, my research analyzes the impact of AUMFs and their potential to delegate constitutional powers to the President through vague language, highly discretionary provisions, and the non-inclusion of specific regulatory measures. Two relevant analytical legal doctrines apply: void-for-vagueness and legislative non-delegation. No scholar has previously applied these two legal doctrines to scrutinize AUMFs and their potential to unconstitutionally empower the President. I draw from historical precedents, specifically U.S. Supreme Court cases concerning executive power, separation-of-powers, and war powers. These cases are critical in understanding the difference between general versus limited wars. By applying legal doctrines and judicial precedents, I argue that AUMFs were originally intended to regulate the President as commander-in-chief. Yet, historically enacted AUMFs have violated these two legal doctrines, unconstitutionally delegating broad war powers to the President. Consequently, presidents execute AUMFs in a highly arbitrary fashion, as the vague language provides discretion to wage virtually unrestricted warfare. My thesis is structured chronologically, with case studies that investigate specific conflict AUMFs. The historical chapters cover the period from the U.S. founding to the Korean War (1789-1950). The case studies include: the 1955 Formosa Resolution and 1957 Middle East Resolution, 1964 Tonkin Gulf Resolution, 1991 Persian Gulf War AUMF, and the 2001 AUMF. My research draws from archival documents and personal interviews conducted with U.S. judges, law professors, historians, and other scholars of U.S. politics.
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- 2020
38. Quasi-two-dimensional modelling of gallium nitride based microwave high power power transistors
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Carpenter, Morgan G., Aaen, P. H., and Sporea, Radu
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621.3815 - Abstract
Increasing demands on mobile networks to provide high speed data rates has led to fifth generation wireless networks. Essential to achieving the high frequencies of operation and powers required are gallium nitride (GaN) high-electron mobility transistors (HEMTs), because of their high efficiency, relatively high voltage breakdown and power handling. As a comparatively young technology, computer modelling is essential to developing and optimizing GaN HEMTs, and current two-dimensional (2D) modelling techniques struggle to efficiently link process parameters to DC and RF performance. Modern undoped devices based on InAlN/GaN heterostructures put further demand on computer models, as they rely on polarisation effects as the main contributors to the current-carrying two-dimensional electron gas channel, rather than doped donor layers found in previous GaAs and GaN devices. The new quasi-two-dimensional physical model presented in this research covers all these issues to accurately simulate device performance from DC to mm-wave. It includes an appropriate treatment of the electric field in the gate region and transport models for hot electron effects such as velocity overshoot, as well as handling electron transport in InAlN alloys, polarisation effects and the effects of undoped and doped layers. It is the first model to account for hot electron effects for undoped GaN-based HEMT devices. The model is used to demonstrate the link between process parameter variation and small-signal performance.
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- 2020
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39. Impact of Biological Sex on Immune Activation and Frequency of the Latent HIV Reservoir During Suppressive Antiretroviral Therapy
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Falcinelli, Shane D, Shook-Sa, Bonnie E, Dewey, Morgan G, Sridhar, Sumati, Read, Jenna, Kirchherr, Jennifer, James, Katherine S, Allard, Brigitte, Ghofrani, Simon, Stuelke, Erin, Baker, Caroline, Roan, Nadia R, Eron, Joseph J, Kuruc, JoAnn D, Ramirez, Catalina, Gay, Cynthia, Mollan, Katie R, Margolis, David M, Adimora, Adaora A, and Archin, Nancie M
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Medical Microbiology ,Biomedical and Clinical Sciences ,Immunology ,Clinical Research ,HIV/AIDS ,Infectious Diseases ,Genetics ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Infection ,Good Health and Well Being ,Adult ,Anti-Retroviral Agents ,CD4-Positive T-Lymphocytes ,CD8-Positive T-Lymphocytes ,Cross-Sectional Studies ,Estrogen Receptor alpha ,Female ,Gene Expression ,HIV Infections ,HIV-1 ,Humans ,Leukocytes ,Mononuclear ,Male ,Middle Aged ,Sex Factors ,Virus Latency ,HIV ,reservoir ,women ,men ,cure ,Biological Sciences ,Medical and Health Sciences ,Microbiology ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundPersistent HIV infection of long-lived resting CD4 T cells, despite antiretroviral therapy (ART), remains a barrier to HIV cure. Women have a more robust type 1 interferon response during HIV infection relative to men, contributing to lower initial plasma viremia. As lower viremia during acute infection is associated with reduced frequency of latent HIV infection, we hypothesized that women on ART would have a lower frequency of latent HIV compared to men.MethodsART-suppressed, HIV seropositive women (n = 22) were matched 1:1 to 22 of 39 ART-suppressed men. We also compared the 22 women to all 39 men, adjusting for age and race as covariates. We measured the frequency of latent HIV using the quantitative viral outgrowth assay, the intact proviral DNA assay, and total HIV gag DNA. We also performed activation/exhaustion immunophenotyping on peripheral blood mononuclear cells and quantified interferon-stimulated gene (ISG) expression in CD4 T cells.ResultsWe did not observe evident sex differences in the frequency of persistent HIV in resting CD4 T cells. Immunophenotyping and CD4 T-cell ISG expression analysis revealed marginal differences across the sexes.ConclusionsDifferences in HIV reservoir frequency and immune activation appear to be small across sexes during long-term suppressive therapy.
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- 2020
40. Radiographic Evaluation of Pediatric Patients with Patellofemoral Instability
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Orellana, Kevin J., Batley, Morgan G., Lawrence, J. Todd R., Nguyen, Jie C., and Williams, Brendan A.
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- 2022
- Full Text
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41. Plant This Not That: A Tool for Improving Invasive Species Identification and Expanding the Use of Sustainable Alternatives in Florida, USA, Landscaping
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S. Brooks Parrish, Tina McIntyre, Morgan G. Pinkerton, and Sandra B. Wilson
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extension ,native plants ,outreach ,sterile cultivars ,Plant culture ,SB1-1110 - Abstract
The newly released “Plant This Not That: A Guide to Avoiding Invasive Plant Species in Florida” booklet emerges as a crucial tool in cultivating a comprehensive understanding of invasive species, facilitating informed decision-making in plant selection. Its unique focus on illustrating alternatives to invasive plants, coupled with its accessible format, can empower individuals to contribute to the preservation of Florida, USA, ecosystems. The booklet’s impact was displayed through an in-service training for 58 University of Florida/Institute of Food and Agricultural Sciences extension personnel. Following the in-service training, attendees demonstrated statistically significant improvements in their perceived knowledge of four key invasive species concepts. This study highlights the booklet and accompanying training’s potential as a valuable resource for mitigating the impacts of invasive plant species.
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- 2023
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42. Potential biomarker of brain response to opioid antagonism in adolescents with eating disorders: a pilot study
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Stephani L. Stancil, Hung-Wen Yeh, Morgan G. Brucks, Amanda S. Bruce, Michaela Voss, Susan Abdel-Rahman, William M. Brooks, and Laura E. Martin
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opioid antagonism ,eating disorders ,naltrexone ,adolescents ,pharmacodynamic biomarker ,fMRI ,Psychiatry ,RC435-571 - Abstract
BackgroundEating Disorders (ED) affect up to 5% of youth and are associated with reward system alterations and compulsive behaviors. Naltrexone, an opioid antagonist, is used to treat ED behaviors such as binge eating and/or purging. The presumed mechanism of action is blockade of reward activation; however, not all patients respond, and the optimal dose is unknown. Developing a tool to detect objective drug response in the brain will facilitate drug development and therapeutic optimization. This pilot study evaluated neuroimaging as a pharmacodynamic biomarker of opioid antagonism in adolescents with ED.MethodsYouth aged 13–21 with binge/purge ED completed functional magnetic resonance imaging (fMRI) pre- and post-oral naltrexone. fMRI detected blood oxygenation-level dependent (BOLD) signal at rest and during two reward probes (monetary incentive delay, MID, and passive food view, PFV) in predefined regions of interest associated with reward and inhibitory control. Effect sizes for Δ%BOLD (post-naltrexone vs. baseline) were estimated using linear mixed effects modeling.ResultsIn 12 youth (16–21 years, 92% female), BOLD signal changes were detected following naltrexone in the nucleus accumbens during PFV (Δ%BOLD −0.08 ± 0.03; Cohen’s d −1.06, p = 0.048) and anterior cingulate cortex during MID (Δ%BOLD 0.06 ± 0.03; Cohen’s d 1.25, p = 0.086).ConclusionfMRI detected acute reward pathway modulation in this small sample of adolescents with binge/purge ED. If validated in future, larger trials, task-based Δ%BOLD detected by fMRI may serve as a pharmacodynamic biomarker of opioid antagonism to facilitate the development of novel therapeutics targeting the reward pathway, enable quantitative pharmacology trials, and inform drug dosing.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT04935931, NCT#04935931.
- Published
- 2023
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43. Beta-delayed-neutron studies of $^{135,136}$Sb and $^{140}$I performed with trapped ions
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Alan, B. S., Caldwell, S. A., Scielzo, N. D., Czeszumska, A., Clark, J. A., Savard, G., Aprahamian, A., Burkey, M. T., Chiara, C. J., Harker, J., Levand, A. F., Marley, S. T., Morgan, G. E., Munson, J. M., Norman, E. B., Nystrom, A., Orford, R., Padgett, S. W., Galvan, A. Perez, Sharma, K. S., Siegl, K., and Strauss, S. Y.
- Subjects
Nuclear Experiment ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Beta-delayed-neutron ($\beta$n) spectroscopy was performed using the Beta-decay Paul Trap and an array of radiation detectors. The $\beta$n branching ratios and energy spectra for $^{135,136}$Sb and $^{140}$I were obtained by measuring the time of flight of recoil ions emerging from the trapped ion cloud. These nuclei are located at the edge of an isotopic region identified as having $\beta$n branching ratios that impact the r-process abundance pattern around the A~130 peak. For $^{135,136}$Sb and $^{140}$I, $\beta$n branching ratios of 14.6(11)%, 17.6(28)%, and 7.6(28)% were determined, respectively. The $\beta$n energy spectra obtained for $^{135}$Sb and $^{140}$I are compared with results from direct neutron measurements, and the $\beta$n energy spectrum for $^{136}$Sb has been measured for the first time.
- Published
- 2019
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44. Moral Responsibility
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Wisneski, Daniel C., Morgan, G. Scott, Bauman, Christopher W., and Farazmand, Ali, editor
- Published
- 2022
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45. Challenges and knowledge gaps with immune checkpoint inhibitors monotherapy in the management of patients with non-small-cell lung cancer: a survey of oncologist perceptions
- Author
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Castelo-Branco, L., Morgan, G., Prelaj, A., Scheffler, M., Canhão, H., Van Meerbeeck, J.P., and Awada, A.
- Published
- 2023
- Full Text
- View/download PDF
46. Nitrosative stress in Parkinson’s disease
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Morgan G. Stykel and Scott D. Ryan
- Subjects
Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Parkinson’s Disease (PD) is a neurodegenerative disorder characterized, in part, by the loss of dopaminergic neurons within the nigral-striatal pathway. Multiple lines of evidence support a role for reactive nitrogen species (RNS) in degeneration of this pathway, specifically nitric oxide (NO). This review will focus on how RNS leads to loss of dopaminergic neurons in PD and whether RNS accumulation represents a central signal in the degenerative cascade. Herein, we provide an overview of how RNS accumulates in PD by considering the various cellular sources of RNS including nNOS, iNOS, nitrate, and nitrite reduction and describe evidence that these sources are upregulating RNS in PD. We document that over 1/3 of the proteins that deposit in Lewy Bodies, are post-translationally modified (S-nitrosylated) by RNS and provide a broad description of how this elicits deleterious effects in neurons. In doing so, we identify specific proteins that are modified by RNS in neurons which are implicated in PD pathogenesis, with an emphasis on exacerbation of synucleinopathy. How nitration of alpha-synuclein (aSyn) leads to aSyn misfolding and toxicity in PD models is outlined. Furthermore, we delineate how RNS modulates known PD-related phenotypes including axo-dendritic-, mitochondrial-, and dopamine-dysfunctions. Finally, we discuss successful outcomes of therapeutics that target S-nitrosylation of proteins in Parkinson’s Disease related clinical trials. In conclusion, we argue that targeting RNS may be of therapeutic benefit for people in early clinical stages of PD.
- Published
- 2022
- Full Text
- View/download PDF
47. Quality control in resting-state fMRI: the benefits of visual inspection
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Rebecca J. Lepping, Hung-Wen Yeh, Brent C. McPherson, Morgan G. Brucks, Mohammad Sabati, Rainer T. Karcher, William M. Brooks, Joshua D. Habiger, Vlad B. Papa, and Laura E. Martin
- Subjects
artifacts ,functional magnetic resonance imaging (fMRI) ,resting state—fMRI ,reproducibility of results ,quality control ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
BackgroundA variety of quality control (QC) approaches are employed in resting-state functional magnetic resonance imaging (rs-fMRI) to determine data quality and ultimately inclusion or exclusion of a fMRI data set in group analysis. Reliability of rs-fMRI data can be improved by censoring or “scrubbing” volumes affected by motion. While censoring preserves the integrity of participant-level data, including excessively censored data sets in group analyses may add noise. Quantitative motion-related metrics are frequently reported in the literature; however, qualitative visual inspection can sometimes catch errors or other issues that may be missed by quantitative metrics alone. In this paper, we describe our methods for performing QC of rs-fMRI data using software-generated quantitative and qualitative output and trained visual inspection.ResultsThe data provided for this QC paper had relatively low motion-censoring, thus quantitative QC resulted in no exclusions. Qualitative checks of the data resulted in limited exclusions due to potential incidental findings and failed pre-processing scripts.ConclusionVisual inspection in addition to the review of quantitative QC metrics is an important component to ensure high quality and accuracy in rs-fMRI data analysis.
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- 2023
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48. A Playbook to be Proud of: Making the Case for LGBTQ+ Inclusive User Account Design
- Author
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Fadrigon, Beatrice, primary, Gordon, Princess, additional, Lupica, Jane, additional, and Ames, Morgan G., additional
- Published
- 2024
- Full Text
- View/download PDF
49. Efficient computation of contributional diversity metrics from microbiome data with FuncDiv.
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Gavin M. Douglas, Sunu Kim, Morgan G. I. Langille, and B. Jesse Shapiro
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- 2023
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50. Integrating phylogenetic and functional data in microbiome studies.
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Gavin M. Douglas, Molly G. Hayes, Morgan G. I. Langille, and Elhanan Borenstein
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- 2022
- Full Text
- View/download PDF
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