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1. Increased biomarkers of cardiovascular risk in HIV-1 viremic controllers and low persistent inflammation in elite controllers and art-suppressed individuals

Author

Caetano, Diogo Gama, Ribeiro-Alves, Marcelo, Hottz, Eugênio Damaceno, Vilela, Larissa Melo, Cardoso, Sandra Wagner, Hoagland, Brenda, Grinsztejn, Beatriz, Veloso, Valdilea Gonçalves, Morgado, Mariza Gonçalves, Bozza, Patrícia Torres, Guimarães, Monick Lindenmeyer, and Côrtes, Fernanda Heloise

Published
2022
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2. Congenital Cytomegalovirus and HIV Perinatal Transmission

Author

Adachi, Kristina, Xu, Jiahong, Ank, Bonnie, Watts, D Heather, Camarca, Margaret, Mofenson, Lynne M, Pilotto, Jose Henrique, Joao, Esau, Gray, Glenda, Theron, Gerhard, Santos, Breno, Fonseca, Rosana, Kreitchmann, Regis, Pinto, Jorge, Mussi-Pinhata, Marisa M, Machado, Daisy Maria, Ceriotto, Mariana, Morgado, Mariza G, Bryson, Yvonne J, Veloso, Valdilea G, Grinsztejn, Beatriz, Mirochnick, Mark, Moye, Jack, and Nielsen-Saines, Karin

Subjects
Reproductive Medicine, Medical Microbiology, Biomedical and Clinical Sciences, HIV/AIDS, Pediatric, Perinatal Period - Conditions Originating in Perinatal Period, Pediatric AIDS, Clinical Research, Infectious Diseases, Conditions Affecting the Embryonic and Fetal Periods, Aetiology, 2.2 Factors relating to the physical environment, Infection, Reproductive health and childbirth, Good Health and Well Being, Anti-Retroviral Agents, Cohort Studies, Cytomegalovirus, Cytomegalovirus Infections, DNA, Viral, Female, HIV Infections, Humans, Infant, Infant, Newborn, Infectious Disease Transmission, Vertical, Pregnancy, Pregnancy Complications, Infectious, Real-Time Polymerase Chain Reaction, Risk Factors, Viral Load, congenital CMV, HIV MTCT, HIV perinatal transmission, MPH for the NICHD HPTN 040 Study Team, Paediatrics and Reproductive Medicine, Public Health and Health Services, Pediatrics, Clinical sciences, Paediatrics
Abstract

BackgroundCongenital cytomegalovirus (CMV) infection (cCMV) is an important cause of hearing loss and cognitive impairment. Prior studies suggest that HIV-exposed children are at higher risk of acquiring cCMV. We assessed the presence, magnitude and risk factors associated with cCMV among infants born to HIV-infected women, who were not receiving antiretrovirals during pregnancy.MethodscCMV and urinary CMV load were determined in a cohort of infants born to HIV-infected women not receiving antiretrovirals during pregnancy. Neonatal urines obtained at birth were tested for CMV DNA by qualitative and reflex quantitative real-time polymerase chain reaction.ResultsUrine specimens were available for 992 (58.9%) of 1684 infants; 64 (6.5%) were CMV-positive. Mean CMV load (VL) was 470,276 copies/ml (range: < 200-2,000,000 copies/ml). Among 89 HIV-infected infants, 16 (18%) had cCMV versus 42 (4.9%) of 858 HIV-exposed, uninfected infants (P < 0.0001). cCMV was present in 23.2% of infants with in utero and 9.1% infants with intrapartum HIV infection (P < 0.0001). Rates of cCMV among HIV-infected infants were 4-fold greater (adjusted OR, 4.4; 95% CI: 2.3-8.2) and 6-fold greater among HIV in utero-infected infants (adjusted OR, 6; 95% CI: 3-12.1) compared with HIV-exposed, uninfected infants. cCMV was not associated with mode of delivery, gestational age, Apgar scores, 6-month infant mortality, maternal age, race/ethnicity, HIV viral load or CD4 count. Primary cCMV risk factors included infant HIV-infection, particularly in utero infection.ConclusionHigh rates of cCMV with high urinary CMV VL were observed in HIV-exposed infants. In utero HIV infection appears to be a major risk factor for cCMV in infants whose mothers have not received combination antiretroviral therapy in pregnancy.

Published
2018

3. Global and regional epidemiology of HIV-1 recombinants in 1990–2015: a systematic review and global survey

Author

Abimiku, Alash'le G, Agwale, Simon, Archibald, Chris, Avidor, Boaz, Barbás, María Gabriela, Barre-Sinoussi, Francoise, Barugahare, Banson, Belabbes, El Hadj, Bertagnolio, Silvia, Birx, Deborah, Bobkov, Aleksei F, Brandful, James, Bredell, Helba, Brennan, Catherine A, Brooks, James, Bruckova, Marie, Buonaguro, Luigi, Buonaguro, Franco, Buttò, Stefano, Buvé, Anne, Campbell, Mary, Carr, Jean, Carrera, Alex, Carrillo, Manuel Gómez, Celum, Connie, Chaplin, Beth, Charles, Macarthur, Chatzidimitriou, Dimitrios, Chen, Zhiwei, Chijiwa, Katsumi, Cooper, David, Cunningham, Philip, Dagnra, Anoumou, de Gascun, Cillian F, Del Amo, Julia, Delgado, Elena, Dietrich, Ursula, Dwyer, Dominic, Ellenberger, Dennis, Ensoli, Barbara, Essex, Max, Gao, Feng, Fleury, Hervé, Fonjungo, Peter N, Foulongne, Vincent, Gadkari, Deepak A, García, Federico, Garsia, Roger, Gershy-Damet, Guy Michel, Glynn, Judith R, Goodall, Ruth, Grossman, Zehava, Lindenmeyer-Guimarães, Monick, Hahn, Beatrice, Hamers, Raph L, Hamouda, Osamah, Handema, Ray, He, Xiang, Herbeck, Joshua, Ho, David D, Holguin, Africa, Hosseinipour, Mina, Hunt, Gillian, Ito, Masahiko, Bel Hadj Kacem, Mohamed Ali, Kahle, Erin, Kaleebu, Pontiano, Kalish, Marcia, Kamarulzaman, Adeeba, Kang, Chun, Kanki, Phyllis, Karamov, Edward, Karasi, Jean-Claude, Kayitenkore, Kayitesi, Kelleher, Tony, Kitayaporn, Dwip, Kostrikis, Leondios G, Kucherer, Claudia, Lara, Claudia, Leitner, Thomas, Liitsola, Kirsi, Lingappa, Jai, Linka, Marek, Lorenzana de Rivera, Ivette, Lukashov, Vladimir, Maayan, Shlomo, Mayr, Luzia, McCutchan, Francine, Meda, Nicolas, Menu, Elisabeth, Mhalu, Fred, Mloka, Doreen, Mokili, John L, Montes, Brigitte, Mor, Orna, Morgado, Mariza, Mosha, Fausta, Moussi, Awatef, Mullins, James, Najera, Rafael, Nasr, Mejda, Ndembi, Nicaise, Neilson, Joel R, Nerurkar, Vivek R, Neuhann, Florian, Nolte, Claudine, Novitsky, Vlad, Nyambi, Philippe, Ofner, Marianna, Paladin, Fem J, Papa, Anna, Pape, Jean, Parkin, Neil, Parry, Chris, Peeters, Martine, Pelletier, Alexandra, Pérez-Álvarez, Lucía, Pillay, Deenan, Pinto, Angie, Quang, Trinh Duy, Rademeyer, Cecilia, Raikanikoda, Filimone, Rayfield, Mark A, Reynes, Jean-Marc, Rinke de Wit, Tobias, Robbins, Kenneth E, Rolland, Morgane, Rousseau, Christine, Salazar-Gonzales, Jesus, Salem, Hanan, Salminen, Mika, Salomon, Horacio, Sandstrom, Paul, Santiago, Mario L, Sarr, Abdoulaye D, Schroeder, Bryan, Segondy, Michel, Selhorst, Philippe, Sempala, Sylvester, Servais, Jean, Shaik, Ansari, Shao, Yiming, Slim, Amine, Soares, Marcelo A, Songok, Elijah, Stewart, Debbie, Stokes, Julie, Subbarao, Shambavi, Sutthent, Ruengpung, Takehisa, Jun, Tanuri, Amilcar, Tee, Kok Keng, Thapa, Kiran, Thomson, Michael, Tran, Tyna, Urassa, Willy, Ushijima, Hiroshi, van de Perre, Philippe, van der Groen, Guido, van Laethem, Kristel, van Oosterhout, Joep, van Sighem, Ard, van Wijngaerden, Eric, Vandamme, Anne-Mieke, Vercauteren, Jurgen, Vidal, Nicole, Wallace, Lesley, Williamson, Carolyn, Wolday, Dawit, Xu, Jianqing, Yang, Chunfu, Zhang, Linqi, Zhang, Rong, Hemelaar, Joris, Elangovan, Ramyiadarsini, Yun, Jason, Dickson-Tetteh, Leslie, Kirtley, Shona, Gouws-Williams, Eleanor, and Ghys, Peter D

Published
2020
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4. Global and regional molecular epidemiology of HIV-1, 1990–2015: a systematic review, global survey, and trend analysis

Author

Abimiku, Alash'le G, Agwale, Simon, Archibald, Chris, Avidor, Boaz, Barbás, María Gabriela, Barre-Sinoussi, Francoise, Barugahare, Banson, Belabbes, El Hadj, Bertagnolio, Silvia, Birx, Deborah, Bobkov, Aleksei F, Brandful, James, Bredell, Helba, Brennan, Catherine A, Brooks, James, Bruckova, Marie, Buonaguro, Luigi, Buonaguro, Franco, Buttò, Stefano, Buve, Anne, Campbell, Mary, Carr, Jean, Carrera, Alex, Carrillo, Manuel Gómez, Celum, Connie, Chaplin, Beth, Charles, Macarthur, Chatzidimitriou, Dimitrios, Chen, Zhiwei, Chijiwa, Katsumi, Cooper, David, Cunningham, Philip, Dagnra, Anoumou, de Gascun, Cillian F, Del Amo, Julia, Delgado, Elena, Dietrich, Ursula, Dwyer, Dominic, Ellenberger, Dennis, Ensoli, Barbara, Essex, Max, Gao, Feng, Fleury, Herve, Fonjungo, Peter N, Foulongne, Vincent, Gadkari, Deepak A, García, Federico, Garsia, Roger, Gershy-Damet, Guy Michel, Glynn, Judith R, Goodall, Ruth, Grossman, Zehava, Lindenmeyer-Guimarães, Monick, Hahn, Beatrice, Hamers, Raph L, Hamouda, Osamah, Handema, Ray, He, Xiang, Herbeck, Joshua, Ho, David D, Holguin, Africa, Hosseinipour, Mina, Hunt, Gillian, Ito, Masahiko, Bel Hadj Kacem, Mohamed Ali, Kahle, Erin, Kaleebu, Pontiano Kaleebu, Kalish, Marcia, Kamarulzaman, Adeeba, Kang, Chun, Kanki, Phyllis, Karamov, Edward, Karasi, Jean-Claude, Kayitenkore, Kayitesi, Kelleher, Tony, Kitayaporn, Dwip, Kostrikis, Leondios G, Kucherer, Claudia, Lara, Claudia, Leitner, Thomas, Liitsola, Kirsi, Lingappa, Jai, Linka, Marek, Lorenzana de Rivera, Ivette, Lukashov, Vladimir, Maayan, Shlomo, Mayr, Luzia, McCutchan, Francine, Meda, Nicolas, Menu, Elisabeth, Mhalu, Fred, Mloka, Doreen, Mokili, John L, Montes, Brigitte, Mor, Orna, Morgado, Mariza, Mosha, Fausta, Moussi, Awatef, Mullins, James, Najera, Rafael, Nasr, Mejda, Ndembi, Nicaise, Neilson, Joel R, Nerurkar, Vivek R, Neuhann, Florian, Nolte, Claudine, Novitsky, Vlad, Nyambi, Philippe, Ofner, Marianna, Paladin, Fem J, Papa, Anna, Pape, Jean, Parkin, Neil, Parry, Chris, Peeters, Martine, Pelletier, Alexandra, Pérez-Álvarez, Lucía, Pillay, Deenan, Pinto, Angie, Quang, Trinh Duy, Rademeyer, Cecilia, Raikanikoda, Filimone, Rayfield, Mark A, Reynes, Jean-Marc, Rinke de Wit, Tobias, Robbins, Kenneth E, Rolland, Morgane, Rousseau, Christine, Salazar-Gonzales, Jesus, Salem, Hanan, Salminen, Mika, Salomon, Horacio, Sandstrom, Paul, Santiago, Mario L, Sarr, Abdoulaye D, Schroeder, Bryan, Segondy, Michel, Selhorst, Philippe, Sempala, Sylvester, Servais, Jean, Shaik, Ansari, Shao, Yiming, Slim, Amine, Soares, Marcelo A, Songok, Elijah, Stewart, Debbie, Stokes, Julie, Subbarao, Shambavi, Sutthent, Ruengpung, Takehisa, Jun, Tanuri, Amilcar, Tee, Kok Keng, Thapa, Kiran, Thomson, Michael, Tran, Tyna, Urassa, Willy, Ushijima, Hiroshi, van de Perre, Philippe, van der Groen, Guido, van Laethem, Kristel, van Oosterhout, Joep, van Sighem, Ard, van Wijngaerden, Eric, Vandamme, Anne-Mieke, Vercauteren, Jurgen, Vidal, Nicole, Wallace, Lesley, Williamson, Carolyn, Wolday, Dawit, Xu, Jianqing, Yang, Chunfu, Zhang, Linqi, Zhang, Rong, Hemelaar, Joris, Elangovan, Ramyiadarsini, Yun, Jason, Dickson-Tetteh, Leslie, Fleminger, Isabella, Kirtley, Shona, Williams, Brian, Gouws-Williams, Eleanor, and Ghys, Peter D

Published
2019
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5. The impact of early anti-SARS-CoV-2 antibody production on the length of hospitalization stay among COVID-19 patients

Author

de Almeida, Dalziza Victalina, primary, Cezar, Priscila Alves, additional, Fernandes, Thais Freitas Barreto, additional, Schwarz, Marcos Gustavo Araujo, additional, Mendonça-Lima, Leila, additional, Giacoia-Gripp, Carmem Beatriz Wagner, additional, Côrtes, Fernanda Heloise, additional, Lindenmeyer Guimarães, Monick, additional, Pilotto, Jose Henrique, additional, De Sá, Nathalia Beatriz Ramos, additional, Cazote, Andressa da Silva, additional, Gomes, Larissa Rodrigues, additional, Quintana, Marcel de Souza Borges, additional, Ribeiro-Alves, Marcelo, additional, Coelho, Lara Esteves, additional, Geraldo, Kim Mattos, additional, Ribeiro, Maria Pia Diniz, additional, Cardoso, Sandra Wagner, additional, Grinsztejn, Beatriz, additional, Veloso, Valdiléa G, additional, and Morgado, Mariza Gonçalves, additional

Published
2023
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6. HIV-1 Controllers Exhibit an Enhanced Antiretroviral Innate State Characterized by Overexpression of p21 and MCPIP1 and Silencing of Endogenous Retroviruses

Author

Azevedo, Suwellen Sardinha Dias de, primary, Ribeiro Alves, Marcelo, additional, Côrtes, Fernanda Heloise, additional, Delatorre, Edson, additional, Hoagland, Brenda, additional, Villela, Larissa M., additional, Grinsztejn, Beatriz, additional, Veloso, Valdiléa Gonçalves, additional, Morgado, Mariza Gonçalves, additional, Souza, Thiago Moreno, additional, and Bello, Gonzalo, additional

Published
2023
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10. Cytomegalovirus Urinary Shedding in HIV-infected Pregnant Women and Congenital Cytomegalovirus Infection

Author

NICHD HPTN 040 Study Team, Adachi, Kristina, Xu, Jiahong, Ank, Bonnie, Watts, D. Heather, Mofenson, Lynne M., Pilotto, Jose Henrique, Joao, Esau, Santos, Breno, Fonseca, Rosana, Kreitchmann, Regis, Pinto, Jorge, Mussi-Pinhata, Marisa M., Gray, Glenda, Theron, Gerhard, Morgado, Mariza G., Bryson, Yvonne J., Veloso, Valdilea G., Klausner, Jeffrey D., Moye, Jack, and Nielsen-Saines, Karin

Published
2017

11. Diversity of anal HPV and Non-HPV Sexually Transmitted Infections and Concordance with Genital Infections in HIV-Infected and HIV-Uninfected Women in the Tapajós Region, Amazon, Brazil

Author

Rodrigues, Luana Lorena Silva, primary, Pilotto, José Henrique, additional, Martinelli, Katrini Guidolini, additional, Nicol, Alcina F., additional, De Paula, Vanessa Salete, additional, Gheit, Tarik, additional, Oliveira, Nathália Silva Carlos, additional, Silva-de-Jesus, Carlos, additional, Sahasrabuddhe, Vikrant V., additional, Da Silva, Diane M., additional, Kast, W. Martin, additional, Hardick, Justin, additional, Gaydos, Charlotte A., additional, and Morgado, Mariza Gonçalves, additional

Published
2023
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13. Ongoing HIV-1 evolution and reservoir reseeding in two elite controllers with genetically diverse peripheral proviral quasispecies

Author

de Azevedo, Suwellen Sardinha Dias, Côrtes, Fernanda Heloise, Villela, Larissa M, Hoagland, Brenda, Grinsztejn, Beatriz, Veloso, Valdilea Gonçalvez, Morgado, Mariza G, and Bello, Gonzalo

Subjects
viral evolution, viral diversity, HIV-1, proviral reservoir, elite controllers
Abstract

BACKGROUND Elite controllers (EC) are human immunodeficiency virus (HIV)-positive individuals who can maintain low viral loads for extended periods without antiretroviral therapy due to multifactorial and individual characteristics. Most have a small HIV-1 reservoir composed of identical proviral sequences maintained by clonal expansion of infected CD4+ T cells. However, some have a more diverse peripheral blood mononuclear cell (PBMC)-associated HIV-1 reservoir with unique sequences. OBJECTIVES To understand the turnover dynamics of the PBMC-associated viral quasispecies in ECs with relatively diverse circulating proviral reservoirs. METHODS We performed single genome amplification of the env gene at three time points during six years in two EC with high intra-host HIV DNA diversity. FINDINGS Both EC displayed quite diverse PBMCs-associated viral quasispecies (mean env diversity = 1.9-4.1%) across all time-points comprising both identical proviruses that are probably clonally expanded and unique proviruses with evidence of ongoing evolution. HIV-1 env glycosylation pattern suggests that ancestral and evolving proviruses may display different phenotypes of resistance to broadly neutralising antibodies consistent with persistent immune pressure. Evolving viruses may progressively replace the ancestral ones or may remain as minor variants in the circulating proviral population. MAIN CONCLUSIONS These findings support that the high intra-host HIV-1 diversity of some EC resulted from long-term persistence of archival proviruses combined with the continuous reservoir’s reseeding and low, but measurable, viral evolution despite undetectable viremia.

Published
2023

14. Inflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil

Author

Neira-Goulart, Milena, primary, de Sá, Nathalia Beatriz Ramos, additional, Ribeiro-Alves, Marcelo, additional, Perazzo, Hugo, additional, Geraldo, Kim Mattos, additional, Ribeiro, Maria Pia Diniz, additional, Cardoso, Sandra Wagner, additional, Grinsztejn, Beatriz, additional, Veloso, Valdiléa G., additional, Rodrigues Gomes, Larissa, additional, Cazote, Andressa da Silva, additional, de Almeida, Dalziza Victalina, additional, Giacoia-Gripp, Carmem Beatriz Wagner, additional, Côrtes, Fernanda Heloise, additional, and Morgado, Mariza Gonçalves, additional

Published
2023
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17. Reduction of inflammation and T cell activation after 6 months of cART initiation during acute, but not in early chronic HIV-1 infection

Author

de Paula, Hury Hellen Souza, Ferreira, Ana Cristina Garcia, Caetano, Diogo Gama, Delatorre, Edson, Teixeira, Sylvia Lopes Maia, Coelho, Lara Esteves, João, Eduarda Grinsztejn, de Andrade, Michelle Morata, Cardoso, Sandra Wagner, Grinsztejn, Beatriz, Veloso, Valdilea Gonçalves, Morgado, Mariza Gonçalves, Guimarães, Monick Lindenmeyer, and Côrtes, Fernanda Heloise

Published
2018
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20. Pretreatment HIV Drug Resistance and HIV-1 Subtype C Are Independently Associated With Virologic Failure: Results From the Multinational PEARLS (ACTG A5175) Clinical Trial

Author

AIDS Clinical Trials Group (ACTG) A5175 Study Team, Kantor, Rami, Smeaton, Laura, Vardhanabhuti, Saran, Hudelson, Sarah E., Wallis, Carol L., Tripathy, Srikanth, Morgado, Mariza G., Saravanan, Shanmugham, Balakrishnan, Pachamuthu, Reitsma, Marissa, Hart, Stephen, Mellors, John W., Halvas, Elias, Grinsztejn, Beatriz, Hosseinipour, Mina C., Kumwenda, Johnstone, La Rosa, Alberto, Lalloo, Umesh G., Lama, Javier R., Rassool, Mohammed, Santos, Breno R., Supparatpinyo, Khuanchai, Hakim, James, Flanigan, Timothy, Kumarasamy, Nagalingeswaran, Campbell, Thomas B., and Eshleman, Susan H.

Published
2015

22. Inflammasome genetic variants are associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes

Author

de Sá, Nathalia Beatriz Ramos, primary, de Souza, Nara Cristina Silva, additional, Neira-Goulart, Milena, additional, Ribeiro-Alves, Marcelo, additional, Da Silva, Tatiana Pereira, additional, Pilotto, Jose Henrique, additional, Rolla, Valeria Cavalcanti, additional, Giacoia-Gripp, Carmem B. W., additional, de Oliveira Pinto, Luzia Maria, additional, Scott-Algara, Daniel, additional, Morgado, Mariza Gonçalves, additional, and Teixeira, Sylvia Lopes Maia, additional

Published
2022
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23. Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, Brazil

Author

de Sá, Nathalia Beatriz Ramos, primary, Neira-Goulart, Milena, additional, Ribeiro-Alves, Marcelo, additional, Perazzo, Hugo, additional, Geraldo, Kim Mattos, additional, Ribeiro, Maria Pia Diniz, additional, Cardoso, Sandra Wagner, additional, Grinsztejn, Beatriz, additional, Veloso, Valdiléa G., additional, Capão, Artur, additional, Siqueira, Marilda Mendonça, additional, de Lima Bezerra, Ohanna Cavalcanti, additional, Garcia, Cristiana Couto, additional, Gomes, Larissa Rodrigues, additional, da Silva Cazote, Andressa, additional, de Almeida, Dalziza Victalina, additional, Giacoia-Gripp, Carmem Beatriz Wagner, additional, Côrtes, Fernanda Heloise, additional, and Morgado, Mariza Gonçalves, additional

Published
2022
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28. Immunogenicity and sustainability of the immune response in Brazilian HIV-1-infected individuals vaccinated with inactivated triple influenza vaccine

Author

Souza, Thiago Moreno L., Santini-Oliveira, Marilia, Martorelli, Andressa, Luz, Paula M., Vasconcellos, Mauricio T.L., Giacoia-Gripp, Carmem B.W., Morgado, Mariza, Nunes, Estevão P., Lemos, Alberto S., Ferreira, Ana C.G., Moreira, Ronaldo I., Veloso, Valdiléa G., Siqueira, Marilda, Grinsztejn, Beatriz, and Camacho, Luiz A.B.

Published
2016
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29. Nlrp3 Inflammasome Genetic Variants Are Associated With Risk And/Or Protection To Hospitalization Among Covid-19 Patients From Rio De Janeiro, Brazil

Author

de Sá, Nathalia Beatriz Ramos, primary, Neira-Goulart, Milena, additional, Ribeiro-Alves, Marcelo, additional, Geraldo, Kim Mattos, additional, Ribeiro, Maria Pia Diniz, additional, Cardoso, Sandra Wagner, additional, Grinsztejn, Beatriz, additional, Veloso, Valdiléa G., additional, Capão, Artur, additional, Siqueira, Marilda Mendonça, additional, Bezerra, Ohanna Cavalcanti de Lima, additional, Garcia, Cristiana Couto, additional, Gomes, Larissa Rodrigues, additional, Cazote, Andressa da Silva, additional, De Almeida, Dalziza Victalina, additional, Giacoia-Gripp, Carmem Beatriz Wagner, additional, Côrtes, Fernanda Heloise, additional, and Morgado, Mariza Gonçalves, additional

Published
2021
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30. Identification of a new circulating recombinant form of human immunodeficiency virus type 1, CRF124_cpx involving subtypes A, G, H, and CRF27_cpx in Angola.

Author

Mendes Da Silva, Rayana Katylin, Morais, Joana, Foley, Brian Thomas, Bello, Gonzalo, Morgado, Mariza Gonçalves, and Lindenmeyer Guimarães, Monick

Subjects
HIV, HIV-positive persons, BAYESIAN analysis, AIDS
Abstract

Angola, located in Central Africa, has around 320,000 (270,000-380,000) people living with human immunodeficiency virus (HIV)/AIDS, equivalent to 1% of the country's population at the end of 2021. A previous study conducted in 2012, using Angolan samples collected between 2008 and 2010 revealed a high prevalence of HIV-1 recombinants, around 42% of sequences, with 21% showing the same UH profile in partial pol region which were grouped into a monophyletic cluster with high bootstrap support. Thus, the objective of the present work was to obtain complete genomes of those sequences and characterize them, aiming at a description of a new circulating recombinant form (CRF). Whole blood from nine HIV-1 UH pol-infected individuals had their genomic DNA extracted, and nested PCR was used to amplify seven overlapping fragments targeting the full-length HIV-1 genome. The final classification was based on maximum likelihood trees, and recombination analyses were performed using a bootscan from the Simplot program. BLAST and Los Alamos Database inspections were used to search other similar H-like pol sequences. Complete genome amplification was possible for three samples, partial genomes were obtained for the other three, and only pol was available for the remaining three sequences. Bootscan analysis of the two whole-genome and three partial genome sequences retrieved from people living with HIV/AIDS (PLHIVA) without epidemiological linkage showed the same complex recombination profile involving HIV-1 subtypes A/G/H/CRF27_ cpx, with a total of six recombinant breakpoints, aiming to classify a new HIV-1 CRF124_cpx. We found no other full-length HIV-1 genomes with the same mosaic profile; however, we identified 33 partial pol sequences, mainly sampled from Angola between 2001 to 2019, with the same H-like profile. Bayesian analysis of H and H-like pol sequences indicates that CRF124_cpx probably originated in Angola at mid-1970s, indicating that this CRF has been circulating in the country for a long time. In summary, our study describes a new CRF circulating principally in Angola and highlights the importance of continuing molecular surveillance studies, especially in countries with high molecular diversity of HIV. [ABSTRACT FROM AUTHOR]

Published
2022
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31. Inflammasome genetic variants are associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes.

Author

Ramos de Sá, Nathalia Beatriz, Silva de Souza, Nara Cristina, Neira-Goulart, Milena, Ribeiro-Alves, Marcelo, Pereira Da Silva, Tatiana, Henrique Pilotto, Jose, Cavalcanti Rolla, Valeria, Giacoia-Gripp, Carmem B. W., de Oliveira Pinto, Luzia Maria, Scott-Algara, Daniel, Gonçalves Morgado, Mariza, and Maia Teixeira, Sylvia Lopes

Subjects
TUBERCULOSIS, GENETIC variation, HAPLOTYPES, SINGLE nucleotide polymorphisms, GENETIC polymorphisms, INFLAMMASOMES, HIV
Abstract

Background: Tuberculosis (TB) and AIDS are the leading causes of infectious diseases death worldwide. Here, we investigated the relationship between from single nucleotide polymorphisms (SNPs) of the NLRP3, CARD8, AIM2, CASP-1, IFI16, and IL-1b inflammasome genes, as well as the profiles of secreted proinflammatory cytokines (e.g., IL-1b, IL-18, IL-33, and IL-6) with the TB clinical profiles, TB-HIV coinfection, and IRIS onset. Methods: The individuals were divided into four groups: TB-HIV group (n=88; 11 of them with IRIS), HIV-1 group (n=20), TB group (n=24) and healthy volunteers (HC) group (n=10), and were followed up at INI/FIOCRUZ and HGNI (Rio de Janeiro/Brazil) from 2006 to 2016. Real-time PCR was used to determine the genotypes of the Single Nucleotide Polymorphism (SNPs), and ELISA was used to measure the plasma cytokine levels. Unconditional logistic regression models were used to perform risk estimations. Results: A higher risk for extrapulmonary TB was associated with the TT genotype (aOR=6.76; P=0.026) in the NLRP3 rs4612666 Single Nucleotide Polymorphism (SNP) and the C-C-T-G-C haplotype (aOR=4.99; P= 0.017) in the NLRP3 variants. This same Single Nucleotide Polymorphism (SNP) was associated with lower risk against extrapulmonary TB when the carrier allele C (aOR=0.15; P=0.021) was present. Among those with HIV-1 infections, a higher risk for TB onset was associated with the GA genotype (aOR=5.5; P=0.044) in the IL1-b rs1143634 Single Nucleotide Polymorphism (SNP). In contrast, lower risk against TB onset was associated with the A-G haplotype (aOR=0.17; P= 0.026) in the CARD8 variants. Higher IL-6 and IL-33 levels were observed in individuals with TB. A higher risk for IRIS onset was associated with CD8 counts = 500 cells/mm3 (aOR=12.32; P=0.010), the presence of extrapulmonary TB (aOR=6.6; P=0.038), and the CT genotype (aOR=61.06; P=0.026) or carrier allele T (aOR=61.06; P=0.026) in the AIM2 rs2276405 Single Nucleotide Polymorphism (SNP), whereas lower risk against IRIS onset was associated with the AT genotype (aOR=0.02; P=0.033) or carrier allele T (aOR=0.02; P=0.029) in the CARD8 rs2043211 Single Nucleotide Polymorphism (SNP) and the T-G haplotype (aOR=0.07; P= 0.033) in the CARD8 variants. No other significant associations were observed. Conclusions: Our results depict the involvement of genetic polymorphisms of crucial innate immunity genes and proinflammatory cytokines in the clinical outcomes related to TB-HIV coinfection. [ABSTRACT FROM AUTHOR]

Published
2022
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32. Killer immunoglobulin-like receptor (KIR) genes are associated with the risk of episodes of high-level and detectable viremia among HIV controllers

Author

De Sá, Nathalia Beatriz Ramos, primary, Silva, Karina dos S., additional, Ribeiro-Alves, Marcelo, additional, Caetano, Diogo Gama, additional, Côrtes, Fernanda Heloise, additional, de Azevedo, Suwellen S. D., additional, Hoagland, Brenda, additional, Grinsztejn, Beatriz, additional, Veloso, Valdilea G., additional, Morgado, Mariza G., additional, and Teixeira, Sylvia Lopes Maia, additional

Published
2021
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38. Molecular epidemiology of HIV-1 infection in a small Brazilian County: Usefulness of envelope and polymerase sequences to epidemiologic studies

Author

Eyer-Silva, Walter A. and Morgado, Mariza G.

Subjects
Brazil -- Health aspects, AIDS (Disease) -- Development and progression, Epidemics, Health
Abstract

A genetic analysis of viral sequences from the small county of Miracema, Rio de Janeiro State is performed as the AIDS epidemic in Brazil is spreading from the large urban centers to small counties and the innermost parts of the country. The polyphyletic pattern suggests multiple viral introductions in the region while intracluster cases, including those with no known direct epidemiologic link, probably took part in the same chain of viral transmission.

Published
2006

40. High emergence of drug resistance after HAART interruption at delivery in a cohort of HIV+ pregnant women submitted to antiretroviral treatment to prevent mother-to-child transmission in Rio de Janeiro, Brazil

Author

Ismerio Ronaldo, Muri Sandra, Khalili Ruth, Ribeiro Jorge Eurico, Velasco-de-Castro Carlos Augusto, Rodrigues-Pedro Adriana, Couto-Fernandez Jose Carlos, Veloso Valdilea, Grinsztejn Beatriz, Pilotto Jose Henrique, Courrier Judith, and Morgado Mariza G

Subjects
Immunologic diseases. Allergy, RC581-607
Published
2009
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41. Assessing the emergence of drug resistance in a cohort of HIV infected pregnant women under HAART for prophylaxis of mother-to-child transmission (MTCT) followed in a referral center in Rio de Janeiro, Brazil

Author

Ismerio Ronaldo, Muri Sandra, Khalili Ruth, Ribeiro Jorge-Eurico, Lima Elizangela, Flores Geane, Rodrigues-Pedro Adriana, Couto-Fernandez Jose-Carlos, Veloso Valdilea, Grinsztejn Beatriz, Pilotto Jose-Henrique, and Morgado Mariza G

Subjects
Immunologic diseases. Allergy, RC581-607
Published
2008
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44. Global and regional epidemiology of HIV-1 recombinants in 1990–2015: a systematic review and global survey

Author

Hemelaar, Joris, primary, Elangovan, Ramyiadarsini, additional, Yun, Jason, additional, Dickson-Tetteh, Leslie, additional, Kirtley, Shona, additional, Gouws-Williams, Eleanor, additional, Ghys, Peter D, additional, Abimiku, Alash'le G, additional, Agwale, Simon, additional, Archibald, Chris, additional, Avidor, Boaz, additional, Barbás, María Gabriela, additional, Barre-Sinoussi, Francoise, additional, Barugahare, Banson, additional, Belabbes, El Hadj, additional, Bertagnolio, Silvia, additional, Birx, Deborah, additional, Bobkov, Aleksei F, additional, Brandful, James, additional, Bredell, Helba, additional, Brennan, Catherine A, additional, Brooks, James, additional, Bruckova, Marie, additional, Buonaguro, Luigi, additional, Buonaguro, Franco, additional, Buttò, Stefano, additional, Buvé, Anne, additional, Campbell, Mary, additional, Carr, Jean, additional, Carrera, Alex, additional, Carrillo, Manuel Gómez, additional, Celum, Connie, additional, Chaplin, Beth, additional, Charles, Macarthur, additional, Chatzidimitriou, Dimitrios, additional, Chen, Zhiwei, additional, Chijiwa, Katsumi, additional, Cooper, David, additional, Cunningham, Philip, additional, Dagnra, Anoumou, additional, de Gascun, Cillian F, additional, Del Amo, Julia, additional, Delgado, Elena, additional, Dietrich, Ursula, additional, Dwyer, Dominic, additional, Ellenberger, Dennis, additional, Ensoli, Barbara, additional, Essex, Max, additional, Gao, Feng, additional, Fleury, Hervé, additional, Fonjungo, Peter N, additional, Foulongne, Vincent, additional, Gadkari, Deepak A, additional, García, Federico, additional, Garsia, Roger, additional, Gershy-Damet, Guy Michel, additional, Glynn, Judith R, additional, Goodall, Ruth, additional, Grossman, Zehava, additional, Lindenmeyer-Guimarães, Monick, additional, Hahn, Beatrice, additional, Hamers, Raph L, additional, Hamouda, Osamah, additional, Handema, Ray, additional, He, Xiang, additional, Herbeck, Joshua, additional, Ho, David D, additional, Holguin, Africa, additional, Hosseinipour, Mina, additional, Hunt, Gillian, additional, Ito, Masahiko, additional, Bel Hadj Kacem, Mohamed Ali, additional, Kahle, Erin, additional, Kaleebu, Pontiano, additional, Kalish, Marcia, additional, Kamarulzaman, Adeeba, additional, Kang, Chun, additional, Kanki, Phyllis, additional, Karamov, Edward, additional, Karasi, Jean-Claude, additional, Kayitenkore, Kayitesi, additional, Kelleher, Tony, additional, Kitayaporn, Dwip, additional, Kostrikis, Leondios G, additional, Kucherer, Claudia, additional, Lara, Claudia, additional, Leitner, Thomas, additional, Liitsola, Kirsi, additional, Lingappa, Jai, additional, Linka, Marek, additional, Lorenzana de Rivera, Ivette, additional, Lukashov, Vladimir, additional, Maayan, Shlomo, additional, Mayr, Luzia, additional, McCutchan, Francine, additional, Meda, Nicolas, additional, Menu, Elisabeth, additional, Mhalu, Fred, additional, Mloka, Doreen, additional, Mokili, John L, additional, Montes, Brigitte, additional, Mor, Orna, additional, Morgado, Mariza, additional, Mosha, Fausta, additional, Moussi, Awatef, additional, Mullins, James, additional, Najera, Rafael, additional, Nasr, Mejda, additional, Ndembi, Nicaise, additional, Neilson, Joel R, additional, Nerurkar, Vivek R, additional, Neuhann, Florian, additional, Nolte, Claudine, additional, Novitsky, Vlad, additional, Nyambi, Philippe, additional, Ofner, Marianna, additional, Paladin, Fem J, additional, Papa, Anna, additional, Pape, Jean, additional, Parkin, Neil, additional, Parry, Chris, additional, Peeters, Martine, additional, Pelletier, Alexandra, additional, Pérez-Álvarez, Lucía, additional, Pillay, Deenan, additional, Pinto, Angie, additional, Quang, Trinh Duy, additional, Rademeyer, Cecilia, additional, Raikanikoda, Filimone, additional, Rayfield, Mark A, additional, Reynes, Jean-Marc, additional, Rinke de Wit, Tobias, additional, Robbins, Kenneth E, additional, Rolland, Morgane, additional, Rousseau, Christine, additional, Salazar-Gonzales, Jesus, additional, Salem, Hanan, additional, Salminen, Mika, additional, Salomon, Horacio, additional, Sandstrom, Paul, additional, Santiago, Mario L, additional, Sarr, Abdoulaye D, additional, Schroeder, Bryan, additional, Segondy, Michel, additional, Selhorst, Philippe, additional, Sempala, Sylvester, additional, Servais, Jean, additional, Shaik, Ansari, additional, Shao, Yiming, additional, Slim, Amine, additional, Soares, Marcelo A, additional, Songok, Elijah, additional, Stewart, Debbie, additional, Stokes, Julie, additional, Subbarao, Shambavi, additional, Sutthent, Ruengpung, additional, Takehisa, Jun, additional, Tanuri, Amilcar, additional, Tee, Kok Keng, additional, Thapa, Kiran, additional, Thomson, Michael, additional, Tran, Tyna, additional, Urassa, Willy, additional, Ushijima, Hiroshi, additional, van de Perre, Philippe, additional, van der Groen, Guido, additional, van Laethem, Kristel, additional, van Oosterhout, Joep, additional, van Sighem, Ard, additional, van Wijngaerden, Eric, additional, Vandamme, Anne-Mieke, additional, Vercauteren, Jurgen, additional, Vidal, Nicole, additional, Wallace, Lesley, additional, Williamson, Carolyn, additional, Wolday, Dawit, additional, Xu, Jianqing, additional, Yang, Chunfu, additional, Zhang, Linqi, additional, and Zhang, Rong, additional

Published
2020
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