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1. Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk

Author: Valle-Hita, Cristina, Díaz-López, Andrés, Becerra-Tomás, Nerea, Martínez-González, Miguel A., García, Verónica Ruiz, Corella, Dolores, Goday, Albert, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Cano-Ibáñez, Naomi, Tur, Josep A., Rubín-García, María, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Fontao, Sebastian Mas, Daimiel, Lidia, Ros, Emilio, Toledo, Estefania, Sorlí, José V., Roca, C., Abete, Iztiar, Moreno-Rodriguez, Anai, Crespo-Oliva, Edelys, Candela-García, Inmaculada, Morey, Marga, Garcia-Rios, Antonio, Casas, Rosa, Fernandez-Garcia, Jose Carlos, Santos-Lozano, José Manuel, Diez-Espino, Javier, Ortega-Azorín, Carolina, Comas, M., Zulet, M. Angeles, Sorto-Sanchez, Carolina, Ruiz-Canela, Miguel, Fitó, Montse, Salas-Salvadó, Jordi, and Babio, Nancy
Published: 2022
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2. Pro-vegetarian food patterns and cardiometabolic risk in the PREDIMED-Plus study: a cross-sectional baseline analysis

Author: Oncina-Cánovas, Alejandro, Vioque, Jesús, González-Palacios, Sandra, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Zomeño, Dolores, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Bernal-Lopez, Rosa M., Lapetra, José, Serra-Majem, J. Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín-Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emili, Toledo, Estefanía, Babio, Nancy, Sorli, Jose V., Schröder, Helmut, Zulet, María Angeles, Sorto-Sánchez, Carolina, Barón-López, Francisco Javier, Compañ-Gabucio, Laura, Morey, Marga, García-Ríos, Antonio, Casas, Rosa, Gómez-Pérez, Ana María, Santos-Lozano, José Manuel, Vázquez-Ruiz, Zenaida, Nishi, Stephanie K., Asensio, Eva M., Soldevila, Núria, Abete, Itziar, Goicolea-Güemez, Leire, Buil-Cosiales, Pilar, García-Gavilán, Jesús F., Canals, Erik, Torres-Collado, Laura, and García-de-la-Hera, Manuela
Published: 2022
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3. Fruit consumption and cardiometabolic risk in the PREDIMED-plus study: A cross-sectional analysis

Author: Becerra-Tomás, Nerea, Paz-Graniel, Indira, Tresserra-Rimbau, Anna, Martínez-González, Miguel Á., Barrubés, Laura, Corella, Dolores, Muñoz-Martínez, Júlia, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, José A., Serra-Majem, Luís, Estruch, Ramon, Bernal-López, Maria R., Lapetra, José, Pintó, Xavier, Tur, Josep A., Garcia-Rios, Antonio, Riquelme Gallego, Blanca, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Velilla-Zancada, Sonsoles, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Buil-Cosiales, Pilar, Babio, Nancy, Fernández-Carrión, Rebeca, Pérez-Vega, Karla A., Morey, Marga, Torres-Collado, Laura, Tojal-Sierra, Lucas, Pérez-López, Jessica, Abete, Itziar, Cabrera, Judith P., Casas, Rosa, Fernández-García, José C., Santos-Lozano, José M., Esteve-Luque, Virginia, Bouzas, Cristina, Fernandez-Lazaro, Cesar I., Sorlí, José V., Freixer, Gala, Martín, Marian, Muñoz, Montserrat G., Salaverria-Lete, Itziar, Toledo, Estefania, Castañer, Olga, and Salas-Salvadó, Jordi
Published: 2021
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4. Contribution of ultra-processed foods in visceral fat deposition and other adiposity indicators: Prospective analysis nested in the PREDIMED-Plus trial

Author: Konieczna, Jadwiga, Morey, Marga, Abete, Itziar, Bes-Rastrollo, Maira, Ruiz-Canela, Miguel, Vioque, Jesus, Gonzalez-Palacios, Sandra, Daimiel, Lidia, Salas-Salvadó, Jordi, Fiol, Miguel, Martín, Vicente, Estruch, Ramón, Vidal, Josep, Martínez-González, Miguel A., Canudas, Silvia, Jover, Antoni J., Fernández-Villa, Tania, Casas, Rosa, Olbeyra, Romina, Buil-Cosiales, Pilar, Babio, Nancy, Schröder, Helmut, Martínez, J. Alfredo, and Romaguera, Dora
Published: 2021
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5. Association between dairy product consumption and hyperuricemia in an elderly population with metabolic syndrome

Author: Mena-Sánchez, Guillermo, Babio, Nancy, Becerra-Tomás, Nerea, Martínez-González, Miguel Á., Díaz-López, Andrés, Corella, Dolores, Zomeño, Maria D., Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, José A., Serra-Majem, Luís, Estruch, Ramon, Bernal, Rosa, Lapetra, José, Pintó, Xavier, Tur, Josep A., Lopez-Miranda, José, Cano-Ibáñez, Naomi, Gaforio, Jose J., Matía-Martín, Pilar, Daimiel, Lidia, Caro, José L. Llisterri, Vidal, Josep, Vázquez, Clotilde, Ros, Emili, Arellano, Ana Garcia, Palau, Antoni, Fernández-Carrión, Rebeca, Pérez-Vega, Karla A., Morey, Marga, de la Hera, Manoli García, Vaquero-Luna, Jessica, Carmona-González, Francisco J., Abete, Itziar, Álvarez-Pérez, Jacqueline, Casas, Rosa, Fernández-García, José C., Santos-Lozano, José M., Corbella, Emili, Sureda, Antoni, Ruiz-Canela, Miguel, Barragán, Rocio, Goday, Albert, Martín, Marian, Altozano Rodado, María C., Toledo, Estefanía, Fitó, Montse, and Salas-Salvadó, Jordi
Published: 2020
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6. Development and Validation of Nutri S-Can, a Short Screener to Evaluate Adherence to the 2018 WCRF/AICR Cancer Prevention Recommendations

Author: Chaplin, Alice, primary, Nafría, Mar, additional, Sesé, Albert, additional, Rayó, Elena, additional, Morey, Marga, additional, Prohens, Lara, additional, and Romaguera, Dora, additional
Published: 2024
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7. Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome

Author: Díaz-López, Andrés, Paz-Graniel, Indira, Ruiz, Verónica, Toledo, Estefanía, Becerra-Tomás, Nerea, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Sánchez, Vicente Martín, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Villa, Tania Fernandez, Ros, Emilio, Eguaras, Sonia, Babio, Nancy, Sorlí, Jose V., Goday, Albert, Abete, Itziar, Sierra, Lucas Tojal, Barón-López, Francisco Javier, Torres-Collado, Laura, Morey, Marga, Garcia-Rios, Antonio, Casas, Rosa, Bernal-López, María Rosa, Santos-Lozano, José Manuel, Navarro, Adela, Gonzalez, Jose I., Zomeño, María Dolores, Zulet, Maria Angeles, Luna, Jessica Vaquero, Ramallal, Raul, Fitó, Montse, and Salas-Salvadó, Jordi
Published: 2021
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8. Validation of the Nutri S-can, A New Tool That Measures Adherence to the 2018 WCRF/AICR Cancer Prevention Recommendations

Author: Chaplin, Alice, Nafria, Mar, Sesé, Albert, Morey, Marga, Prohens, Lara, Rayó, Elena, and Romaguera, Dora
Published: 2024
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9. Impact of COVID-19 pandemic on the PREDIMED-Plus randomized clinical trial: Effects on the interventions, participants follow-up, and adiposity

Author: Paz-Graniel, Indira, primary, Fitó, Montserrat, additional, Ros, Emilio, additional, Buil-Cosiales, Pilar, additional, Corella, Dolores, additional, Babio, Nancy, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Serra-Majem, Lluis, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Martín-Sánchez, Vicente, additional, Pintó, Xavier, additional, Gaforio, José Juan, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, García-Gavilán, Jesus F., additional, Toledo, Estefanía, additional, Nishi, Stephanie K., additional, Sorlí, Jose V., additional, Castañer, Olga, additional, García-Ríos, Antonio, additional, García de la Hera, Manoli, additional, Barón-López, Francisco Javier, additional, Ruiz-Canela, Miguel, additional, Morey, Marga, additional, Casas, Rosa, additional, Garrido-Garrido, Eva María, additional, Tojal-Sierra, Lucas, additional, Fernández-García, José C., additional, Vázquez-Ruiz, Zenaida, additional, Fernández-Carrión, Rebeca, additional, Goday, Albert, additional, Peña-Orihuela, Patricia J., additional, Compañ-Gabucio, Laura, additional, Schröder, Helmut, additional, Martínez-Gonzalez, Miguel A., additional, and Salas-Salvadó, Jordi, additional
Published: 2023
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10. Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk

Author: Rubín-García, María, Vitelli-Storelli, Facundo, Álvarez-Álvarez, Laura, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Hernáez, Álvaro, Martínez, J Alfredo, Alonso-Gómez, Ángel M, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Serra-Majem, Luís I, Cano-Ibañez, Naomi, Tur, Josep A, Marcos-Delgado, Alba, Tresserra-Rimbau, Anna, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emili, Vázquez-Ruiz, Zenaida, Babio, Nancy, Barragán, Rocío, Castañer-Niño, Olga, Razquin, Cristina, Tojal-Sierra, Lucas, Gómez-Gracia, Enrique, González-Palacios, Sandra, Morey, Marga, García-Rios, Antonio, Castro-Barquero, Sara, Bernal-López, María Rosa, Santos-Lozano, José Manuel, Ruiz-Canela, Miguel, Castro-Salomó, Antoni, Pascual-Castelló, Eva Cristina, Moldon, Verónica, Bullón-Vela, Vanessa, Sorto-Sanchez, Carolina, Cenoz-Osinaga, Juan Carlos, Gutiérrez, Liliana, Mengual, Maira, Lamuela-Raventós, Rosa María, Martín-Sánchez, Vicente, PREDIMED‐Plus Trial Investigators, and European Commission
Subjects: Male, Coumaric Acids, Polyphenols, Hyperuricemia, Uric Acid, Cross-Sectional Studies, Cardiovascular Diseases, Risk Factors, Heart Disease Risk Factors, Hydroxybenzoates, Humans, Female, Cardiology and Cardiovascular Medicine
Abstract: BACKGROUND: Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. METHODS AND RESULTS: This cross-sectional analysis involved baseline data of 6332 participants. Food polyphenol content was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer database. Multivariable-adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, −0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, −0.27 to −0.06]) and hydroxycinnamic acids (β coefficient, −0.19 [95% CI, −0.3 to −0.09]), alkylmethoxyphenols (β coefficient, −0.2 [95% CI, −0.31 to −0.1]), and methoxyphenols (β coefficient, −0.24 [95% CI, −0.34 to −0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71–0.95]; PR, 0.82 [95% CI, 0.71–0.95]; PR, 0.80 [95% CI, 0.70–0.92]; and PR, 0.79 [95% CI, 0.69–0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02–0.26]) but not with hyperuricemia. CONCLUSIONS: In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic acids, alkylmethoxyphenol, and methoxyphenol) was inversely associated with serum uric acid levels and hyperuricemia. Nevertheless, our findings warrant further research., European Research Council (ERC) European Commission 2013-2018 340918, official funding agency for biomedical research of the Spanish government Instituto de Salud Carlos III, European Commission PI13/00673 PI13/00492 PI13/00272 PI13/01123 PI13/00462 PI13/00233 PI13/02184 PI13/00728 PI13/01090 PI13/01056 PI14/01722 PI14/00636 PI14/00618 PI14/00696 PI14/01206 PI14/01919, Especial Action Project, La Caixa Foundation 2013ACUP00194, Consejo Interinstitucional de Ciencia y Tecnologia (CICYT) AGL2016-75329-R, Center for Forestry Research & Experimentation (CIEF), European Commission PROMETEO/2017/017, Generalitat de Catalunya SGR-2019, Junta de Andalucia PI0458/2013 PS0358/2016 PI0137/2018, SEMERGEN (Sociedad Espanola de Medicos de Atencion Primaria), European Cooperation in Science and Technology (COST), IDISBA (Instituto de Investigacion Sanitaria Islas Baleares), European Commission CIBEROBN CB06/03 CB12/03, European Commission European Commission Joint Research Centre EAT2BENI-CE_H2020_SFS2016, Spanish Ministry of Science, Innovation and Universities for the Formacion de Profesorado Universitario FPU17/00785, Instituto de Salud Carlos III, through the Fondo de Investigacion para la Salud - European Regional Development Fund PI16/00501 PI16/00533 PI16/00381 PI16/00366 PI16/01522 PI16/01120 PI17/00764 PI17/01183 PI17/00855 PI17/01347 PI17/00525 PI17/01827 PI17/00532 PI17/00215 PI17/01441 PI17/00508 PI17/01732 PI17/00926 PI19/00957 PI16/00473, Instituto de Salud Carlos III European Commission PI14/00853 PI14/01374 PI14/00972 PI19/00386 PI19/00309 PI19/01032 PI19/00576 PI19/00017 PI19/01226 PI19/00781 PI19/01560 PI16/00662 PI16/01873 PI16/01094 PI19/01332 PI14/00728 PI14/01471
Published: 2022
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11. Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome

Author: Valle-Hita, Cristina, primary, Becerra-Tomás, Nerea, additional, Díaz-López, Andrés, additional, Vázquez-Ruiz, Zenaida, additional, Megías, Isabel, additional, Corella, Dolores, additional, Goday, Albert, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Serra-Majem, Lluís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Martín-Sánchez, Vicente, additional, Pintó, Xavier, additional, Gaforio, José J., additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Amengual-Galbarte, Angela, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, García-Arellano, Ana, additional, Barragán, Rocío, additional, Fitó, Montse, additional, Peña-Orihuela, Patricia J., additional, Asencio-Aznar, Alberto, additional, Gómez-Gracia, Enrique, additional, Martinez-Urbistondo, Diego, additional, Morey, Marga, additional, Casas, Rosa, additional, Garrido-Garrido, Eva María, additional, Tojal-Sierra, Lucas, additional, Damas-Fuentes, Miguel, additional, Goñi, Estibaliz, additional, Ortega-Azorín, Carolina, additional, Castañer, Olga, additional, Garcia-Rios, Antonio, additional, Gisbert-Sellés, Cristina, additional, Sayón-Orea, Carmen, additional, Schröder, Helmut, additional, Salas-Salvadó, Jordi, additional, and Babio, Nancy, additional
Published: 2022
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12. Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk

Author: Marhuenda-Muñoz, María, primary, Domínguez-López, Inés, additional, Langohr, Klaus, additional, Tresserra-Rimbau, Anna, additional, Martínez González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Zomeño, María Dolores, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Angel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramón, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Serra-Majem, Ll., additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Martín-Sánchez, Vicente, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, Toledo, Estefanía, additional, Fernández de la Puente Cervera, María, additional, Barragán, Rocío, additional, Fitó, Montse, additional, Tojal-Sierra, Lucas, additional, Gómez-Gracia, Enrique, additional, Zazo, Juan Manuel, additional, Morey, Marga, additional, García-Ríos, Antonio, additional, Casas, Rosa, additional, Gómez-Pérez, Ana M., additional, Santos-Lozano, José Manuel, additional, Vázquez-Ruiz, Zenaida, additional, Atzeni, Alessandro, additional, Asensio, Eva M., additional, Gili-Riu, M. Mar, additional, Bullon, Vanessa, additional, Moreno-Rodriguez, Anai, additional, Lecea, Oscar, additional, Babio, Nancy, additional, Peñas Lopez, Francesca, additional, Gómez Melis, Guadalupe, additional, and Lamuela-Raventós, Rosa M., additional
Published: 2022
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13. Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk

Author: Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Generalitat de Catalunya, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), European Research Council, Junta de Andalucía, Generalitat Valenciana, Marhuenda-Muñoz, María, Domínguez-López, Inés, Langohr, Klaus, Tresserra-Rimbau, Anna, Martínez González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Zomeño Fajardo, Maria Dolores, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín-Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Toledo, Estefanía, Fernández de la Puente Cervera, María, Barragán, Rocío, Fitó, Montserrat, Tojal-Sierra, Lucas, Gómez-Gracia, Enrique, Zazo, Juan Manuel, Morey, Marga, Garcia-Rios, Antonio, Casas, Rosa, Gómez-Pérez, Ana María, Santos-Lozano, José Manuel, Vázquez-Ruiz, Zenaida, Atzeni, Alessandro, Asensio, Eva M., Gili-Riu, M. Mar, Bullon, Vanessa, Moreno-Rodríguez, Anai, Lecea, Óscar, Babio, Nancy, Peñas Lopez, Francesca, Gómez Melis, Guadalupe, Lamuela-Raventós, Rosa M., Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III, Generalitat de Catalunya, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), European Research Council, Junta de Andalucía, Generalitat Valenciana, Marhuenda-Muñoz, María, Domínguez-López, Inés, Langohr, Klaus, Tresserra-Rimbau, Anna, Martínez González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Zomeño Fajardo, Maria Dolores, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín-Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Toledo, Estefanía, Fernández de la Puente Cervera, María, Barragán, Rocío, Fitó, Montserrat, Tojal-Sierra, Lucas, Gómez-Gracia, Enrique, Zazo, Juan Manuel, Morey, Marga, Garcia-Rios, Antonio, Casas, Rosa, Gómez-Pérez, Ana María, Santos-Lozano, José Manuel, Vázquez-Ruiz, Zenaida, Atzeni, Alessandro, Asensio, Eva M., Gili-Riu, M. Mar, Bullon, Vanessa, Moreno-Rodríguez, Anai, Lecea, Óscar, Babio, Nancy, Peñas Lopez, Francesca, Gómez Melis, Guadalupe, and Lamuela-Raventós, Rosa M.
Abstract: Carotenoid intake has been reported to be associated with improved cardiovascular health, but there is little information on actual plasma concentrations of these compounds as biomarkers of cardiometabolic risk. The objective was to investigate the association between circulating plasma carotenoids and different cardiometabolic risk factors and the plasma fatty acid profile. This is a cross-sectional evaluation of baseline data conducted in a subcohort (106 women and 124 men) of an ongoing multi-factorial lifestyle trial for primary cardiovascular prevention. Plasma concentrations of carotenoids were quantified by liquid chromatography coupled to mass spectrometry. The associations between carotenoid concentrations and cardiometabolic risk factors were assessed using regression models adapted for interval-censored variables. Carotenoid concentrations were cross-sectionally inversely associated with serum triglyceride concentrations [−2.79 mg/dl (95% CI: −4.25, −1.34) and −5.15 mg/dl (95% CI: −7.38, −2.93), p-values = 0.0002 and <0.00001 in women and men, respectively], lower levels of plasma saturated fatty acids [−0.09% (95% CI: −0.14, −0.03) and −0.15 % (95% CI: −0.23, −0.08), p-values = 0.001 and 0.0001 in women and men, respectively], and higher levels of plasma polyunsaturated fatty acids [(0.12 % (95% CI: −0.01, 0.25) and 0.39 % (95% CI: 0.19, 0.59), p-values = 0.065 and 0.0001 in women and men, respectively] in the whole population. Plasma carotenoid concentrations were also associated with higher plasma HDL-cholesterol in women [0.47 mg/dl (95% CI: 0.23, 0.72), p-value: 0.0002], and lower fasting plasma glucose in men [−1.35 mg/dl (95% CI: −2.12, −0.59), p-value: 0.001].
Published: 2022

14. Pro-vegetarian food patterns and cardiometabolic risk in the PREDIMED-Plus study: a cross-sectional baseline analysis

Author: Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Research Council, Junta de Andalucía, Generalitat Valenciana, Oncina-Canovas, Alejandro, Vioque, Jesús, González-Palacios, Sandra, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Zomeño Fajardo, Maria Dolores, Martínez, J. A., Alonso-Gómez, Ángel M., Wärnberg, Julia, Romaguera, Dora, López-Miranda, José, Estruch, Ramón, Bernal-López, María Rosa, Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín-Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Toledo, Estefanía, Babio, Nancy, Sorlí, Jose V., Schröder, Helmut, Zulet, M. Ángeles, Sorto-Sánchez, Carolina2, Barón-López, Francisco Javier, Compañ-Gabucio, Laura, Morey, Marga, Garcia-Rios, Antonio, Casas, Rosa, Gómez-Pérez, Ana María, Santos-Lozano, José Manuel, Vázquez-Ruiz, Zenaida, Nishi, Stephanie K., Asensio, Eva M., Soldevila, Núria, Abete, Itziar, Goicolea-Güemez, Leire, Buil-Cosiales, Pilar, García-Gavilán, Jesús F., Canals, Erik, Torres-Collado, Laura, García de la Hera, Manuela, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Research Council, Junta de Andalucía, Generalitat Valenciana, Oncina-Canovas, Alejandro, Vioque, Jesús, González-Palacios, Sandra, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Zomeño Fajardo, Maria Dolores, Martínez, J. A., Alonso-Gómez, Ángel M., Wärnberg, Julia, Romaguera, Dora, López-Miranda, José, Estruch, Ramón, Bernal-López, María Rosa, Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín-Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Toledo, Estefanía, Babio, Nancy, Sorlí, Jose V., Schröder, Helmut, Zulet, M. Ángeles, Sorto-Sánchez, Carolina2, Barón-López, Francisco Javier, Compañ-Gabucio, Laura, Morey, Marga, Garcia-Rios, Antonio, Casas, Rosa, Gómez-Pérez, Ana María, Santos-Lozano, José Manuel, Vázquez-Ruiz, Zenaida, Nishi, Stephanie K., Asensio, Eva M., Soldevila, Núria, Abete, Itziar, Goicolea-Güemez, Leire, Buil-Cosiales, Pilar, García-Gavilán, Jesús F., Canals, Erik, Torres-Collado, Laura, and García de la Hera, Manuela
Abstract: [Purpose]: We explored the cross-sectional association between the adherence to three different provegetarian (PVG) food patterns defined as general (gPVG), healthful (hPVG) and unhealthful (uPVG), and the cardiometabolic risk in adults with metabolic syndrome (MetS) of the PREDIMED-Plus randomized intervention study. [Methods]: We performed a cross-sectional analysis of baseline data from 6439 participants of the PREDIMED-Plus randomized intervention study. The gPVG food pattern was built by positively scoring plant foods (vegetables/fruits/legumes/grains/potatoes/nuts/olive oil) and negatively scoring, animal foods (meat and meat products/animal fats/eggs/fish and seafood/dairy products). The hPVG and uPVG were generated from the gPVG by adding four new food groups (tea and coffee/fruit juices/sugar-sweetened beverages/sweets and desserts), splitting grains and potatoes and scoring them differently. Multivariable-adjusted robust linear regression using MM-type estimator was used to assess the association between PVG food patterns and the standardized Metabolic Syndrome score (MetS z-score), a composed index that has been previously used to ascertain the cardiometabolic risk, adjusting for potential confounders. [Results]: A higher adherence to the gPVG and hPVG was associated with lower cardiometabolic risk in multivariable models. The regression coefficients for 5th vs. 1st quintile were − 0.16 (95% CI: − 0.33 to 0.01) for gPVG (p trend: 0.015), and − 0.23 (95% CI: − 0.41 to − 0.05) for hPVG (p trend: 0.016). In contrast, a higher adherence to the uPVG was associated with higher cardiometabolic risk, 0.21 (95% CI: 0.04 to 0.38) (p trend: 0.019). [Conclusion]: Higher adherence to gPVG and hPVG food patterns was generally associated with lower cardiovascular risk, whereas higher adherence to uPVG was associated to higher cardiovascular risk.
Published: 2022

15. Pro-vegetarian food patterns and cardiometabolic risk in the PREDIMED-Plus study: a cross-sectional baseline analysis

Author: Universitat Rovira i Virgili, Oncina-Canovas, Alejandro; Vioque, Jesus; Gonzalez-Palacios, Sandra; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Corella, Dolores; Zomeno, Dolores; Alfredo Martinez, J.; Alonso-Gomez, Angel M.; Warnberg, Julia; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Bernal-Lopez, Rosa M.; Lapetra, Jose; Luis Serra-Majem, J.; Bueno-Cavanillas, Aurora; Tur, Josep A.; Martin-Sanchez, Vicente; Pinto, Xavier; Delgado-Rodriguez, Miguel; Matia-Martin, Pilar; Vidal, Josep; Vazquez, Clotilde; Daimiel, Lidia; Ros, Emili; Toledo, Estefania; Babio, Nancy; Sorli, Jose, V; Schroder, Helmut; Angeles Zulet, Maria; Sorto-Sanchez, Carolina; Javier Baron-Lopez, Francisco; Compan-Gabucio, Laura; Morey, Marga; Garcia-Rios, Antonio; Casas, Rosa; Maria Gomez-Perez, Ana; Manuel Santos-Lozano, Jose; Vazquez-Ruiz, Zenaida; Nishi, Stephanie K.; Asensio, Eva M.; Soldevila, Nuria; Abete, Itziar; Goicolea-Guemez, Leire; Buil-Cosiales, Pilar; Garcia-Gavilan, Jesus F.; Canals, Erik; Torres-Collado, Laura; Garcia-de-la-Hera, Manuela, Universitat Rovira i Virgili, and Oncina-Canovas, Alejandro; Vioque, Jesus; Gonzalez-Palacios, Sandra; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Corella, Dolores; Zomeno, Dolores; Alfredo Martinez, J.; Alonso-Gomez, Angel M.; Warnberg, Julia; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Bernal-Lopez, Rosa M.; Lapetra, Jose; Luis Serra-Majem, J.; Bueno-Cavanillas, Aurora; Tur, Josep A.; Martin-Sanchez, Vicente; Pinto, Xavier; Delgado-Rodriguez, Miguel; Matia-Martin, Pilar; Vidal, Josep; Vazquez, Clotilde; Daimiel, Lidia; Ros, Emili; Toledo, Estefania; Babio, Nancy; Sorli, Jose, V; Schroder, Helmut; Angeles Zulet, Maria; Sorto-Sanchez, Carolina; Javier Baron-Lopez, Francisco; Compan-Gabucio, Laura; Morey, Marga; Garcia-Rios, Antonio; Casas, Rosa; Maria Gomez-Perez, Ana; Manuel Santos-Lozano, Jose; Vazquez-Ruiz, Zenaida; Nishi, Stephanie K.; Asensio, Eva M.; Soldevila, Nuria; Abete, Itziar; Goicolea-Guemez, Leire; Buil-Cosiales, Pilar; Garcia-Gavilan, Jesus F.; Canals, Erik; Torres-Collado, Laura; Garcia-de-la-Hera, Manuela
Abstract: Purpose We explored the cross-sectional association between the adherence to three different provegetarian (PVG) food patterns defined as general (gPVG), healthful (hPVG) and unhealthful (uPVG), and the cardiometabolic risk in adults with metabolic syndrome (MetS) of the PREDIMED-Plus randomized intervention study. Methods We performed a cross-sectional analysis of baseline data from 6439 participants of the PREDIMED-Plus randomized intervention study. The gPVG food pattern was built by positively scoring plant foods (vegetables/fruits/legumes/grains/potatoes/nuts/olive oil) and negatively scoring, animal foods (meat and meat products/animal fats/eggs/fish and seafood/dairy products). The hPVG and uPVG were generated from the gPVG by adding four new food groups (tea and coffee/fruit juices/sugar-sweetened beverages/sweets and desserts), splitting grains and potatoes and scoring them differently. Multivariable-adjusted robust linear regression using MM-type estimator was used to assess the association between PVG food patterns and the standardized Metabolic Syndrome score (MetS z-score), a composed index that has been previously used to ascertain the cardiometabolic risk, adjusting for potential confounders. Results A higher adherence to the gPVG and hPVG was associated with lower cardiometabolic risk in multivariable models. The regression coefficients for 5th vs. 1st quintile were - 0.16 (95% CI: - 0.33 to 0.01) for gPVG (p trend: 0.015), and - 0.23 (95% CI: - 0.41 to - 0.05) for hPVG (p trend: 0.016). In contrast, a higher adherence to the uPVG was associated with higher cardiometabolic risk, 0.21 (95% CI: 0.04 to 0.38) (p trend: 0.019). Conclusion Higher adherence to gPVG and hPVG food patterns was generally associated with lower cardiovascular risk, whereas higher a
Published: 2022

16. Pro-vegetarian food patterns and cardiometabolic risk in the PREDIMED-Plus study: a cross-sectional baseline analysis

Author: Oncina-Cánovas, Alejandro, primary, Vioque, Jesús, additional, González-Palacios, Sandra, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Zomeño, Dolores, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Bernal-Lopez, Rosa M., additional, Lapetra, José, additional, Serra-Majem, J. Luís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Martín-Sánchez, Vicente, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emili, additional, Toledo, Estefanía, additional, Babio, Nancy, additional, Sorli, Jose V., additional, Schröder, Helmut, additional, Zulet, María Angeles, additional, Sorto-Sánchez, Carolina, additional, Barón-López, Francisco Javier, additional, Compañ-Gabucio, Laura, additional, Morey, Marga, additional, García-Ríos, Antonio, additional, Casas, Rosa, additional, Gómez-Pérez, Ana María, additional, Santos-Lozano, José Manuel, additional, Vázquez-Ruiz, Zenaida, additional, Nishi, Stephanie K., additional, Asensio, Eva M., additional, Soldevila, Núria, additional, Abete, Itziar, additional, Goicolea-Güemez, Leire, additional, Buil-Cosiales, Pilar, additional, García-Gavilán, Jesús F., additional, Canals, Erik, additional, Torres-Collado, Laura, additional, and García-de-la-Hera, Manuela, additional
Published: 2021
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17. Consumption of Caffeinated Beverages and Kidney Function Decline in an Elderly Mediterranean Population with Metabolic Syndrome

Author: Medicina, Medikuntza, Díaz López, Andrés, Paz Graniel, Indira, Ruiz, Verónica, Toledo, Estefanía, Becerra Tomás, Nerea, Corella, Dolores, Castañer, Olga, Martínez Hernández, José Alfredo, Alonso Gómez, Ángel María, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra Majem, Lluís, Bueno Cavanillas, Aurora, Tur, Josep A., Martín Sánchez, Vicente, Pintó, Xavier, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Fernández Villa, Tania, Ros, Emilio, Eguaras, Sonia, Babio, Nancy, Sorli, José Vicente, Goday, Albert, Abete, Itziar, Tojal Sierra, Lucas, Barón López, Francisco Javier, Torres Collado, Laura, Morey, Marga, García Ríos, Antonio, Casas, Rosa, Bernal López, María Rosa, Santos Lozano, José Manuel, Navarro, Adela, González, José I., Zomeño Blanquerna, María Dolores, Zulet, M. Ángeles, Vaquero Luna, Jessica, Ramallal, Raul, Fitó, Montserrat, Salas Salvadó, Jordi, Medicina, Medikuntza, Díaz López, Andrés, Paz Graniel, Indira, Ruiz, Verónica, Toledo, Estefanía, Becerra Tomás, Nerea, Corella, Dolores, Castañer, Olga, Martínez Hernández, José Alfredo, Alonso Gómez, Ángel María, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra Majem, Lluís, Bueno Cavanillas, Aurora, Tur, Josep A., Martín Sánchez, Vicente, Pintó, Xavier, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Fernández Villa, Tania, Ros, Emilio, Eguaras, Sonia, Babio, Nancy, Sorli, José Vicente, Goday, Albert, Abete, Itziar, Tojal Sierra, Lucas, Barón López, Francisco Javier, Torres Collado, Laura, Morey, Marga, García Ríos, Antonio, Casas, Rosa, Bernal López, María Rosa, Santos Lozano, José Manuel, Navarro, Adela, González, José I., Zomeño Blanquerna, María Dolores, Zulet, M. Ángeles, Vaquero Luna, Jessica, Ramallal, Raul, Fitó, Montserrat, and Salas Salvadó, Jordi
Abstract: It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and 1-year changes in glomerular filtration rate (eGFR) in a large Spanish cohort of overweight/obese elderly with metabolic syndrome (MetS). This prospective analysis includes 5851 overweight/obese adults (55–75 years) with MetS from the PREDIMED-Plus study. We assessed coffee, tea, and caffeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate-adjusted regression models were applied to test associations between baseline coffee, tea, or caffeine intake and 1-year eGFR changes. Caffeinated coffee (> 2 cups/day) and tea (at least 1 cup/day) drinkers had 0.88 and 0.93 mL/min/1.73 m2 greater eGFR decrease respectively, compared to those with less than 1 cup/day of coffee consumption or non-tea drinkers. Furthermore, caffeinated coffee consumption of > 2 cups/day was associated with 1.19-fold increased risk of rapid eGFR decline > 3 mL/min/1.73 m2 (95% CI 1.01–1.41). Similarly, individuals in the highest (median, 51.2 mg/day) tertile of caffeine intake had a 0.87 mL/min/1.73 m2 greater eGFR decrease. Decaffeinated coffee was not associated with eGFR changes. In conclusion, higher consumption of caffeinated coffee, tea, and caffeine was associated with a greater 1-year eGFR decline in overweight/obese adults with MetS.
Published: 2021

18. Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial

Author: Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Commission, European Research Council, Junta de Andalucía, Generalitat Valenciana, Díaz-López, Andrés, Becerra-Tomás, Nerea, Ruiz, Verónica, Toledo, Estefanía, Babio, Nancy, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, López-Miranda, José, Cano-Ibáñez, Naomi, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Paz, José Antonio de, Vidal, Josep, Vázquez, Clotilde, Ruiz-Canela, Miguel, Bulló, Mònica, Sorlí, Jose V., Goday, Albert, Fiol, Miquel, García de la Hera, Manuela, Tojal-Sierra, Lucas, Pérez-Farinós, Napoleón, Zulet, M. Ángeles, Sánchez-Villegas, Almudena, Sacanella, Emilio, Fernandez-Garcia, José Carlos, Santos-Lozano, José Manuel, Gimenez-Gracia, Miquel, Bibiloni, Maria del Mar, Díez-Espino, Javier, Ortega-Azorín, Carolina, Castañer, Olga, Morey, Marga, Torres-Collado, Laura, Sorto-Sánchez, Carolina, Muñoz, Miguel Ángel, Ros, Emilio, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Commission, European Research Council, Junta de Andalucía, Generalitat Valenciana, Díaz-López, Andrés, Becerra-Tomás, Nerea, Ruiz, Verónica, Toledo, Estefanía, Babio, Nancy, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, López-Miranda, José, Cano-Ibáñez, Naomi, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Paz, José Antonio de, Vidal, Josep, Vázquez, Clotilde, Ruiz-Canela, Miguel, Bulló, Mònica, Sorlí, Jose V., Goday, Albert, Fiol, Miquel, García de la Hera, Manuela, Tojal-Sierra, Lucas, Pérez-Farinós, Napoleón, Zulet, M. Ángeles, Sánchez-Villegas, Almudena, Sacanella, Emilio, Fernandez-Garcia, José Carlos, Santos-Lozano, José Manuel, Gimenez-Gracia, Miquel, Bibiloni, Maria del Mar, Díez-Espino, Javier, Ortega-Azorín, Carolina, Castañer, Olga, Morey, Marga, Torres-Collado, Laura, Sorto-Sánchez, Carolina, Muñoz, Miguel Ángel, Ros, Emilio, Martínez-González, Miguel Ángel, and Salas-Salvadó, Jordi
Abstract: Introduction: Large randomized trials testing the effect of a multifactorial weight-loss lifestyle intervention including Mediterranean diet (MedDiet) on renal function are lacking. Here, we evaluated the 1-year efficacy of an intensive weight-loss intervention with an energy-reduced MedDiet (erMedDiet) plus increased physical activity (PA) on renal function. Methods: Randomized controlled "PREvención con DIeta MEDiterránea-Plus"(PREDIMED-Plus) trial is conducted in 23 Spanish centers comprising 208 primary care clinics. Overweight/obese (n = 6,719) adults aged 55-75 years with metabolic syndrome were randomly assigned (1:1) to an intensive weight-loss lifestyle intervention with an erMedDiet, PA promotion, and behavioral support (intervention) or usual-care advice to adhere to an energy-unrestricted MedDiet (control) between September 2013 and December 2016. The primary outcome was 1-year change in estimated glomerular filtration rate (EGFR). Secondary outcomes were changes in urine albumin-to-creatinine ratio (UACR), incidence of moderately/severely impaired EGFR (<60 mL/min/1.73 m2) and micro-to macroalbuminuria (UACR ≥30 mg/g), and reversion of moderately (45 to <60 mL/min/1.73 m2) to mildly impaired GFR (60 to <90 mL/min/1.73 m2) or micro-to macroalbuminuria. Results: After 1 year, EGFR declined by 0.66 and 1.25 mL/min/1.73 m2 in the intervention and control groups, respectively (mean difference, 0.58 mL/min/1.73 m2; 95% CI: 0.15-1.02). There were no between-group differences in mean UACR or micro-to macroalbuminuria changes. Moderately/severely impaired EGFR incidence and reversion of moderately to mildly impaired GFR were 40% lower (HR 0.60; 0.44-0.82) and 92% higher (HR 1.92; 1.35-2.73), respectively, in the intervention group. Conclusions: The PREDIMED-Plus lifestyle intervention approach may preserve renal function and delay CKD progression in overweight/obese adults.
Published: 2021

19. Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome

Author: Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Research Council, European Commission, Junta de Andalucía, Generalitat Valenciana, AstraZeneca, Govern de les Illes Balears, Ministerio de Educación, Cultura y Deporte (España), Institución Catalana de Investigación y Estudios Avanzados, Díaz-López, Andrés, Paz-Graniel, Indira, Ruiz, Verónica, Toledo, Estefanía, Becerra-Tomás, Nerea, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Fernández-Villa, Tania, Ros, Emilio, Eguaras, Sonia, Babio, Nancy, Sorlí, Jose V., Goday, Albert, Abete, Itziar, Tojal-Sierra, Lucas, Barón-López, Francisco Javier, Torres-Collado, Laura, Morey, Marga, Garcia-Rios, Antonio, Casas, Rosa, Bernal-López, María Rosa, Santos-Lozano, José Manuel, Navarro, Adela, González, José I., Zomeño Fajardo, Maria Dolores, Zulet, M. Ángeles, Vaquero-Luna, Jessica, Ramallal, Raúl, Fitó, Montserrat, Salas-Salvadó, Jordi, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Research Council, European Commission, Junta de Andalucía, Generalitat Valenciana, AstraZeneca, Govern de les Illes Balears, Ministerio de Educación, Cultura y Deporte (España), Institución Catalana de Investigación y Estudios Avanzados, Díaz-López, Andrés, Paz-Graniel, Indira, Ruiz, Verónica, Toledo, Estefanía, Becerra-Tomás, Nerea, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Fernández-Villa, Tania, Ros, Emilio, Eguaras, Sonia, Babio, Nancy, Sorlí, Jose V., Goday, Albert, Abete, Itziar, Tojal-Sierra, Lucas, Barón-López, Francisco Javier, Torres-Collado, Laura, Morey, Marga, Garcia-Rios, Antonio, Casas, Rosa, Bernal-López, María Rosa, Santos-Lozano, José Manuel, Navarro, Adela, González, José I., Zomeño Fajardo, Maria Dolores, Zulet, M. Ángeles, Vaquero-Luna, Jessica, Ramallal, Raúl, Fitó, Montserrat, and Salas-Salvadó, Jordi
Abstract: It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and 1-year changes in glomerular filtration rate (eGFR) in a large Spanish cohort of overweight/obese elderly with metabolic syndrome (MetS). This prospective analysis includes 5851 overweight/obese adults (55–75 years) with MetS from the PREDIMED-Plus study. We assessed coffee, tea, and caffeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate-adjusted regression models were applied to test associations between baseline coffee, tea, or caffeine intake and 1-year eGFR changes. Caffeinated coffee (> 2 cups/day) and tea (at least 1 cup/day) drinkers had 0.88 and 0.93 mL/min/1.73 m greater eGFR decrease respectively, compared to those with less than 1 cup/day of coffee consumption or non-tea drinkers. Furthermore, caffeinated coffee consumption of > 2 cups/day was associated with 1.19-fold increased risk of rapid eGFR decline > 3 mL/min/1.73 m (95% CI 1.01–1.41). Similarly, individuals in the highest (median, 51.2 mg/day) tertile of caffeine intake had a 0.87 mL/min/1.73 m greater eGFR decrease. Decaffeinated coffee was not associated with eGFR changes. In conclusion, higher consumption of caffeinated coffee, tea, and caffeine was associated with a greater 1-year eGFR decline in overweight/obese adults with MetS.
Published: 2021

20. High Fruit and Vegetable Consumption and Moderate Fat Intake Are Associated with Higher Carotenoid Concentration in Human Plasma

Author: Universitat Rovira i Virgili, Marhuenda-Munoz, Maria; Rinaldi de Alvarenga, Jose Fernando; Hernaez, Alvaro; Tresserra-Rimbau, Anna; Martinez-Gonzalez, Miguel Angel; Salas-Salvado, Jordi; Corella, Dolores; Malcampo, Mireia; Martinez, Jose Alfredo; Alonso-Gomez, Angel M.; Warnberg, Julia; Vioque, Jesus; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Tinahones, Francisco J.; Lapetra, Jose; Serra-Majem, J. Lluis; Bueno-Cavanillas, Aurora; Tur, Josep A.; Sanchez, Vicente Martin; Pinto, Xavier; Delgado-Rodriguez, Miguel; Matia-Martin, Pilar; Vidal, Josep; Vazquez, Clotilde; Daimiel, Lidia; Ros, Emilio; Serra-Mir, Merce; Vazquez-Ruiz, Zenaida; Nishi, Stephanie K.; Sorli, Jose V.; Zomeno, Maria Dolores; Zulet, Maria Angeles; Vaquero-Luna, Jessica; Carabano-Moral, Rosa; Notario-Barandiaran, Leyre; Morey, Marga; Garcia-Rios, Antonio; Gomez-Perez, Ana M.; Santos-Lozano, Jose Manuel; Buil-Cosiales, Pilar; Basora, Josep; Portoles, Olga; Schroder, Helmut; Abete, Itziar; Salaverria-Lete, Itziar; Toledo, Estefania; Babio, Nancy; Fito, Montse; Martinez-Huelamo, Miriam; Lamuela-Raventos, Rosa M., Universitat Rovira i Virgili, and Marhuenda-Munoz, Maria; Rinaldi de Alvarenga, Jose Fernando; Hernaez, Alvaro; Tresserra-Rimbau, Anna; Martinez-Gonzalez, Miguel Angel; Salas-Salvado, Jordi; Corella, Dolores; Malcampo, Mireia; Martinez, Jose Alfredo; Alonso-Gomez, Angel M.; Warnberg, Julia; Vioque, Jesus; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Tinahones, Francisco J.; Lapetra, Jose; Serra-Majem, J. Lluis; Bueno-Cavanillas, Aurora; Tur, Josep A.; Sanchez, Vicente Martin; Pinto, Xavier; Delgado-Rodriguez, Miguel; Matia-Martin, Pilar; Vidal, Josep; Vazquez, Clotilde; Daimiel, Lidia; Ros, Emilio; Serra-Mir, Merce; Vazquez-Ruiz, Zenaida; Nishi, Stephanie K.; Sorli, Jose V.; Zomeno, Maria Dolores; Zulet, Maria Angeles; Vaquero-Luna, Jessica; Carabano-Moral, Rosa; Notario-Barandiaran, Leyre; Morey, Marga; Garcia-Rios, Antonio; Gomez-Perez, Ana M.; Santos-Lozano, Jose Manuel; Buil-Cosiales, Pilar; Basora, Josep; Portoles, Olga; Schroder, Helmut; Abete, Itziar; Salaverria-Lete, Itziar; Toledo, Estefania; Babio, Nancy; Fito, Montse; Martinez-Huelamo, Miriam; Lamuela-Raventos, Rosa M.
Abstract: Carotenoids are pigments contained mainly in fruit and vegetables (F&V) that have beneficial effects on cardiometabolic health. Due to their lipophilic nature, co-ingestion of fat appears to increase their bioavailability via facilitating transfer to the aqueous micellar phase during digestion. However, the extent to which high fat intake may contribute to increased carotenoid plasma concentrations is still unclear. The objective was to examine the degree to which the consumption of different amounts of both carotenoid-rich foods and fats is associated with plasma carotenoid concentrations within a Mediterranean lifestyle context (subsample from the PREDIMED-Plus study baseline) where consumption of F&V and fat is high. The study population was categorized into four groups according to their self-reported consumption of F&V and fat. Carotenoids were extracted from plasma samples and analyzed by HPLC-UV-VIS-QqQ-MS/MS. Carotenoid systemic concentrations were greater in high consumers of F&V than in low consumers of these foods (+3.04 mu mol/L (95% CI: 0.90, 5.17), p-value = 0.005), but circulating concentrations seemed to decrease when total fat intake was very high (-2.69 mu mol/L (-5.54; 0.16), p-value = 0.064). High consumption of F&V is associated with greater systemic levels of total carotenoids, in particular when fat intake is low-to-moderate rather than very high.
Published: 2021

21. Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial

Author: Universitat Rovira i Virgili, Diaz-Lopez, Andres; Becerra-Tomas, Nerea; Ruiz, Veronica; Toledo, Estefania; Babio, Nancy; Corella, Dolores; Fito, Montse; Romaguera, Dora; Vioque, Jesus; Alonso-Gomez, Angel M.; Warnberg, Julia; Martinez, J. Alfredo; Serra-Majem, Luis; Estruch, Ramon; Tinahones, Francisco J.; Lapetra, Jose; Pinto, Xavier; Tur, Josep A.; Lopez-Miranda, Jose; Cano Ibanez, Naomi; Delgado-Rodriguez, Miguel; Matia-Martin, Pilar; Daimiel, Lidia; Antonio de Paz, Jose; Vidal, Josep; Vazquez, Clotilde; Ruiz-Canela, Miguel; Bullo, Monica; Sorli, Jose, V; Goday, Albert; Fiol, Miquel; Garcia-de-la-Hera, Manoli; Sierra, Lucas Tojal; Perez-Farinos, Napoleon; Zulet, Maria Angeles; Sanchez-Villegas, Almudena; Sacanella, Emilio; Carlos Fernandez-Garcia, Jose; Manuel Santos-Lozano, Jose; Gimenez-Gracia, Miquel; Bibiloni, Maria Del Mar; Diez-Espino, Javier; Ortega-Azorin, Carolina; Castaner, Olga; Morey, Marga; Torres-Collado, Laura; Sorto Sanchez, Carolina; Angel Munoz, Miguel; Ros, Emilio; Martinez-Gonzalez, Miguel A.; Salas-Salvado, Jordi;PREDIMED-Plus Investigators, Universitat Rovira i Virgili, and Diaz-Lopez, Andres; Becerra-Tomas, Nerea; Ruiz, Veronica; Toledo, Estefania; Babio, Nancy; Corella, Dolores; Fito, Montse; Romaguera, Dora; Vioque, Jesus; Alonso-Gomez, Angel M.; Warnberg, Julia; Martinez, J. Alfredo; Serra-Majem, Luis; Estruch, Ramon; Tinahones, Francisco J.; Lapetra, Jose; Pinto, Xavier; Tur, Josep A.; Lopez-Miranda, Jose; Cano Ibanez, Naomi; Delgado-Rodriguez, Miguel; Matia-Martin, Pilar; Daimiel, Lidia; Antonio de Paz, Jose; Vidal, Josep; Vazquez, Clotilde; Ruiz-Canela, Miguel; Bullo, Monica; Sorli, Jose, V; Goday, Albert; Fiol, Miquel; Garcia-de-la-Hera, Manoli; Sierra, Lucas Tojal; Perez-Farinos, Napoleon; Zulet, Maria Angeles; Sanchez-Villegas, Almudena; Sacanella, Emilio; Carlos Fernandez-Garcia, Jose; Manuel Santos-Lozano, Jose; Gimenez-Gracia, Miquel; Bibiloni, Maria Del Mar; Diez-Espino, Javier; Ortega-Azorin, Carolina; Castaner, Olga; Morey, Marga; Torres-Collado, Laura; Sorto Sanchez, Carolina; Angel Munoz, Miguel; Ros, Emilio; Martinez-Gonzalez, Miguel A.; Salas-Salvado, Jordi;PREDIMED-Plus Investigators
Abstract: Introduction: Large randomized trials testing the effect of a multifactorial weight-loss lifestyle intervention including Mediterranean diet (MedDiet) on renal function are lacking. Here, we evaluated the 1-year efficacy of an intensive weight-loss intervention with an energy-reduced MedDiet (erMedDiet) plus increased physical activity (PA) on renal function. Methods: Randomized controlled PREvencion con DIeta MEDiterranea-Plus (PREDIMED-Plus) trial is conducted in 23 Spanish centers comprising 208 primary care clinics. Overweight/obese (n = 6,719) adults aged 55-75 years with metabolic syndrome were randomly assigned (1:1) to an intensive weight-loss lifestyle intervention with an erMedDiet, PA promotion, and behavioral support (intervention) or usual-care advice to adhere to an energy-unrestricted MedDiet (control) between September 2013 and December 2016. The primary outcome was 1-year change in estimated glomerular filtration rate (eGFR). Secondary outcomes were changes in urine albumin-to-creatinine ratio (UACR), incidence of moderately/severely impaired eGFR (<60 mL/min/1.73 m(2)) and micro- to macroalbuminuria (UACR >= 30 mg/g), and reversion of moderately (45 to <60 mL/min/1.73 m(2)) to mildly impaired GFR (60 to <90 mL/min/1.73 m(2)) or micro- to macroalbuminuria. Results: After 1 year, eGFR declined by 0.66 and 1.25 mL/min/1.73 m(2) in the intervention and control groups, respectively (mean difference, 0.58 mL/min/1.73 m(2); 95% CI: 0.15-1.02). There were no between-group differences in mean UACR or micro- to macroalbuminuria changes. Moderately/severely impaired eGFR incidence and reversion of moderately to mildly impaired GFR were 40% lower (HR 0.60; 0.44-0.82) and 92% higher (HR 1.92; 1.35-2.73), respectively, in the intervention group. Conclusions: The PRE
Published: 2021

22. High Fruit and Vegetable Consumption and Moderate Fat Intake Are Associated with Higher Carotenoid Concentration in Human Plasma

Author: Marhuenda-Muñoz, María, primary, Rinaldi de Alvarenga, José Fernando, additional, Hernáez, Álvaro, additional, Tresserra-Rimbau, Anna, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Malcampo, Mireia, additional, Martínez, José Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramón, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Serra-Majem, J. Lluís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Sánchez, Vicente Martín, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, Serra-Mir, Mercè, additional, Vázquez-Ruiz, Zenaida, additional, Nishi, Stephanie K., additional, Sorlí, Jose V., additional, Zomeño, María Dolores, additional, Zulet, María Angeles, additional, Vaquero-Luna, Jessica, additional, Carabaño-Moral, Rosa, additional, Notario-Barandiaran, Leyre, additional, Morey, Marga, additional, García-Ríos, Antonio, additional, Gómez-Pérez, Ana M., additional, Santos-Lozano, José Manuel, additional, Buil-Cosiales, Pilar, additional, Basora, Josep, additional, Portolés, Olga, additional, Schröder, Helmut, additional, Abete, Itziar, additional, Salaverria-Lete, Itziar, additional, Toledo, Estefanía, additional, Babio, Nancy, additional, Fitó, Montse, additional, Martínez-Huélamo, Miriam, additional, and Lamuela-Raventós, Rosa M, additional
Published: 2021
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23. Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial

Author: Díaz-López, Andrés, primary, Becerra-Tomás, Nerea, additional, Ruiz, Verónica, additional, Toledo, Estefanía, additional, Babio, Nancy, additional, Corella, Dolores, additional, Fíto, Montse, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel M, additional, Wärnberg, Julia, additional, Martínez, J.Alfredo, additional, Serra-Majem, Luís, additional, Estruch, Ramon, additional, Tinahones, Francisco J, additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep, additional, López-Miranda, José, additional, Ibañez, Naomi Cano, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Paz, Jose Antonio de la, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ruiz-Canela, Miguel, additional, Bulló, Mònica, additional, Sorlí, José V, additional, Goday, Albert, additional, Fiol, Miquel, additional, García-de-la-Hera, Manoli, additional, Sierra, Lucas Tojal, additional, Pérez-Farinós, Napoleón, additional, Zulet, Maria Angeles, additional, Sánchez-Villegas, Almudena, additional, Sacanella, Emilio, additional, Fernández-García, José Carlos, additional, Santos-Lozano, José Manuel, additional, Gimenez-Gracia, Miquel, additional, Bibiloni, Maria del Mar, additional, Diez-Espino, Javier, additional, Ortega-Azorin, Carolina, additional, Castañer, Olga, additional, Morey, Marga, additional, Torres-Collado, Laura, additional, Sanchez, Carolina Sorto, additional, Muñoz, Miguel Ángel, additional, Ros, Emilio, additional, Martínez-González, Miguel A, additional, and Salas-Salvadó, Jordi, additional
Published: 2020
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24. Adherence to the Mediterranean Lifestyle and Desired Body Weight Loss in a Mediterranean Adult Population with Overweight: A PREDIMED-Plus Study

Author: Bouzas, Cristina, primary, Bibiloni, Maria del Mar, additional, Julibert, Alicia, additional, Ruiz-Canela, Miguel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Zomeño, Maria Dolors, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Martínez, J. Alfredo, additional, Serra-Majem, Luís, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Pintó, Xavier, additional, García Ríos, Antonio, additional, Bueno-Cavanillas, Aurora, additional, Gaforio, José J., additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Martín-Sánchez, Vicente, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Fernandez-Lázaro, Cesar Ignacio, additional, Becerra-Tomás, Nerea, additional, Gimenez-Alba, Ignacio Manuel, additional, Muñoz, Julia, additional, Morey, Marga, additional, Oncina-Canovas, Alejandro, additional, Tojal-Sierra, Lucas, additional, Pérez-López, Jéssica, additional, Abete, Itziar, additional, Casañas-Quintana, Tamara, additional, Castro-Barquero, Sara, additional, Bernal-López, M. Rosa, additional, Santos-Lozano, José Manuel, additional, Galera, Ana, additional, Angullo-Martinez, Escarlata, additional, Basterra-Gortari, F. Javier, additional, Basora, Josep, additional, Saiz, Carmen, additional, Castañer, Olga, additional, Martín, Marian, additional, Notario-Barandiarán, Leyre, additional, Belló-Mora, María C., additional, Sayón-Orea, Carmen, additional, García-Gavilán, Jesús, additional, Goday, Albert, additional, and Tur, Josep A., additional
Published: 2020
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25. El entorno urbano construido como estrategia de prevención de la diabetes mellitus tipo 2

Author: Colom, Antoni, Ruiz, Maurici, Barón López, Francisco Javier, Compa, Montserrat, Martín, Marian, Morey, Marga, Romaguera Bosch, Dora, Wärnberg, Julia, Colom, Antoni, Ruiz, Maurici, Barón López, Francisco Javier, Compa, Montserrat, Martín, Marian, Morey, Marga, Romaguera Bosch, Dora, and Wärnberg, Julia
Published: 2019

26. Cross-sectional association between non-soy legume consumption, serum uric acid and hyperuricemia: the PREDIMED-Plus study

Author: Instituto de Salud Carlos III, European Commission, European Research Council, Junta de Andalucía, Generalitat Valenciana, Becerra-Tomás, Nerea, Mena-Sánchez, Guillermo, Díaz-López, Andrés, Martínez-González, Miguel Ángel, Babio, Nancy, Corella, Dolores, Freixer, Gala, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Fernández-García, José C., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Gaforio, José Juan, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Razquin, Cristina, Abellán Cano, Iván, Sorlí, José V., Torres, Laura, Morey, Marga, Navarrete-Muñoz, María A., Tojal Sierra, Lucas, Crespo-Oliva, Edelys, Zulet, M. Ángeles, Sanchez-Villegas, Almudena, Casas, Rosa, Bernal-Lopez, M, Rosa, Santos-Lozano, J. M., Corbella, Emili, Bibiloni, Maria del Mar, Ruiz-Canela, Miguel, Fernández-Carrión, Rebeca, Quifer, Mireia, Prieto, Rafel M., Fernandez-Brufal, Noelia, Salaverria Lete, Itziar, Cenoz, Juan Carlos, Llimona, Regina, Salas-Salvadó, Jordi, Instituto de Salud Carlos III, European Commission, European Research Council, Junta de Andalucía, Generalitat Valenciana, Becerra-Tomás, Nerea, Mena-Sánchez, Guillermo, Díaz-López, Andrés, Martínez-González, Miguel Ángel, Babio, Nancy, Corella, Dolores, Freixer, Gala, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Fernández-García, José C., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Gaforio, José Juan, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Razquin, Cristina, Abellán Cano, Iván, Sorlí, José V., Torres, Laura, Morey, Marga, Navarrete-Muñoz, María A., Tojal Sierra, Lucas, Crespo-Oliva, Edelys, Zulet, M. Ángeles, Sanchez-Villegas, Almudena, Casas, Rosa, Bernal-Lopez, M, Rosa, Santos-Lozano, J. M., Corbella, Emili, Bibiloni, Maria del Mar, Ruiz-Canela, Miguel, Fernández-Carrión, Rebeca, Quifer, Mireia, Prieto, Rafel M., Fernandez-Brufal, Noelia, Salaverria Lete, Itziar, Cenoz, Juan Carlos, Llimona, Regina, and Salas-Salvadó, Jordi
Abstract: [Purpose]: To assess the association between the consumption of non-soy legumes and different subtypes of non-soy legumes and serum uric acid (SUA) or hyperuricemia in elderly individuals with overweight or obesity and metabolic syndrome. [Methods]:A cross-sectional analysis was conducted in the framework of the PREDIMED-Plus study. We included 6329 participants with information on non-soy legume consumption and SUA levels. Non-soy legume consumption was estimated using a semi-quantitative food frequency questionnaire. Linear regression models and Cox regression models were used to assess the associations between tertiles of non-soy legume consumption, different subtypes of non-soy legume consumption and SUA levels or hyperuricemia prevalence, respectively., [Results]: Individuals in the highest tertile (T3) of total non-soy legume, lentil and pea consumption, had 0.14 mg/dL, 0.19 mg/dL and 0.12 mg/dL lower SUA levels, respectively, compared to those in the lowest tertile (T1), which was considered the reference one. Chickpea and dry bean consumption showed no association. In multivariable models, participants located in the top tertile of total non-soy legumes [prevalence ratio (PR): 0.89; 95% CI 0.82–0.97; p trend = 0.01, lentils (PR: 0.89; 95% CI 0.82–0.97; p trend = 0.01), dry beans (PR: 0.91; 95% C: 0.84–0.99; p trend = 0.03) and peas (PR: 0.89; 95% CI 0.82–0.97; p trend = 0.01)] presented a lower prevalence of hyperuricemia (vs. the bottom tertile). Chickpea consumption was not associated with hyperuricemia prevalence., [Conclusions]: In this study of elderly subjects with metabolic syndrome, we observed that despite being a purine-rich food, non-soy legumes were inversely associated with SUA levels and hyperuricemia prevalence.
Published: 2019

27. Mediterranean Built Environment and Precipitation as Modulator Factors on Physical Activity in Obese Mid-Age and Old-Age Adults with Metabolic Syndrome: Cross-Sectional Study

Author: Universitat Rovira i Virgili, Colom, Antoni; Ruiz, Maurici; Warnberg, Julia; Compa, Montserrat; Muncunill, Josep; Javier Baron-Lopez, Francisco; Carlos Benavente-Marin, Juan; Cabeza, Elena; Morey, Marga; Fito, Montserrat; Salas-Salvado, Jordi; Romaguera, Dora, Universitat Rovira i Virgili, and Colom, Antoni; Ruiz, Maurici; Warnberg, Julia; Compa, Montserrat; Muncunill, Josep; Javier Baron-Lopez, Francisco; Carlos Benavente-Marin, Juan; Cabeza, Elena; Morey, Marga; Fito, Montserrat; Salas-Salvado, Jordi; Romaguera, Dora
Abstract: When promoting physical activity (PA) participation, it is important to consider the plausible environmental determinants that may affect this practice. The impact of objectively-measured public open spaces (POS) and walk-friendly routes on objectively-measured and self-reported PA was explored alongside the influence of rainy conditions on this association, in a Mediterranean sample of overweight or obese senior adults with metabolic syndrome. Cross-sectional analyses were undertaken on 218 PREDIMED-Plus trial participants aged 55–75 years, from the city of Palma, in Mallorca (Spain). Indicators of access to POS and walk-friendly routes were assessed in a 1.0 and 0.5 km sausage network walkable buffers around each participant’s residence using geographic information systems. Mean daily minutes of self-reported leisure-time brisk walking, and accelerometer objectively-measured moderate-to-vigorous PA in bouts of at least 10 min (OM-MVPA) were measured. To investigate the association between access to POS and walk-friendly routes with PA, generalized additive models with a Gaussian link function were used. Interaction of rainy conditions with the association between access to POS and walk-friendly routes with OM-MVPA was also examined. Better access to POS was not statistically significantly associated with self-reported leisure-time brisk walking or OM-MVPA. A positive significant association was observed only between distance of walk-friendly routes contained or intersected by buffer and OM-MVPA, and was solely evident on non-rainy days. In this elderly Mediterranean population, only access to walk-friendly routes had an influence on accelerometer-measured PA. Rainy conditions during the accelerometer wear period did appear to modify this association.
Published: 2019

28. Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk

Author: Papandreou, Christopher, primary, Babio, Nancy, additional, Díaz-López, Andrés, additional, Martínez-González, Miguel, additional, Becerra-Tomas, Nerea, additional, Corella, Dolores, additional, Schröder, Helmut, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel, additional, Wärnberg, Julia, additional, Martínez, Alfredo, additional, Serra-Majem, Lluís, additional, Estruch, Ramon, additional, Muñoz-Garach, Araceli, additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep, additional, Garcia-Rios, Antonio, additional, Bueno-Cavanillas, Aurora, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Martín-Sánchez, Vicente, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Ruiz-Canela, Miguel, additional, Bulló, Mónica, additional, Sorli, Jose, additional, Quifer, Mireia, additional, Colom, Antoni, additional, Oncina-Canovas, Alejandro, additional, Tojal-Sierra, Lucas, additional, Barón-López, Javier, additional, Pérez-Farinós, Napoleón, additional, Abete, Itziar, additional, Sanchez-Villegas, Almudena, additional, Casas, Rosa, additional, Fernández-Garcia, José, additional, Santos-Lozano, José, additional, Corbella, Emili, additional, del M. Bibiloni, Maria, additional, Diez-Espino, Javier, additional, Asensio, Eva, additional, Torras, Laura, additional, Morey, Marga, additional, Compañ-Gabucio, Laura, additional, Salaverria-Lete, Itziar, additional, Cenoz-Osinaga, Juan, additional, Castañer, Olga, additional, and Salas-Salvadó, Jordi, additional
Published: 2019
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29. Mediterranean Built Environment and Precipitation as Modulator Factors on Physical Activity in Obese Mid-Age and Old-Age Adults with Metabolic Syndrome: Cross-Sectional Study

Author: Colom, Antoni, primary, Ruiz, Maurici, additional, Wärnberg, Julia, additional, Compa, Montserrat, additional, Muncunill, Josep, additional, Barón-López, Francisco, additional, Benavente-Marín, Juan, additional, Cabeza, Elena, additional, Morey, Marga, additional, Fitó, Montserrat, additional, Salas-Salvadó, Jordi, additional, and Romaguera, Dora, additional
Published: 2019
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30. Mediterranean Built Environment and Weather as Modulator Factors on Physical Activity: Cross-Sectional Study

Author: Colom, Antoni, primary, Ruiz, Maurici, additional, Muncunill, Josep, additional, Wärnberg, Julia, additional, Compa, Montserrat, additional, Baron, Javier, additional, Pérez, Napoleón, additional, Morey, Marga, additional, Cabeza, Elena, additional, Fiol, Miquel, additional, and Romague, Dora, additional
Published: 2018
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31. Association between Access to Public Open Spaces and Physical Activity in a Mediterranean Population at High Cardiovascular Risk

Author: Colom, Antoni, primary, Fiol, Miguel, additional, Ruiz, Maurici, additional, Compa, Montserrat, additional, Morey, Marga, additional, Moñino, Manuel, additional, and Romaguera, Dora, additional
Published: 2018
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32. Impact of mediterranean diet promotion on environmental sustainability: a longitudinal analysis

Author: Tecnologia de los Alimentos, Álvarez Fernández, Laura, Vitelli Storelli, Facundo Ezequiel, Rubín García, María, Oricheta García, María Silvia, Bouzas, Cristina, Ruiz Canela, Miguel, Corella, Dolores, Corella, D., Salas Savadó, Jordi, Fitõ, Montserrat, Martínez, Jose Alfredo, Tojal-sierra, Lucas, Wärnberg, Julia, Vioque, Jesus L., Romaguera, D., López Miranda, José, Estruch, Ramón Sarrate, Tinahones, Francisco J., Santos Lozano, José Manuel, Serra Majem, Lluis I, Bueno Cavanillas, Aurora, Martín Sánchez, Vicente, García Fernández, María del Camino, Esteve-luque, Virginia, Delgado-rodríquez, Miguel, Torrego-ellacuría, Macarena, Vidal Cortada, Josep Rafael Cuauhtémoc Acoltzi, Arancio Prieto, Lucía, Daimiel, L. A., Casas, Rosa, García-arellano, Ana, Shyam, Sangeetha, González, José Ignacio, Castañer, Olga, García Ríos, Antonio, Ortiz Díaz, F., Fernández, A. C., Sánchez-villegas, Almudena, Morey, Marga, Cano-ibáñez, Naomi, Sorto Sánchez, Carolina, Bernal López, María Rosa, Bes-rastrollo, Maira, Nishi, Stephanie K., Coltell, Oscar, Zomeño, María Dolores, Peã±a-orihuela, Patricia Judith, Aparicio, D. V., Zulet, María A, Vázquez, Z., Babio, Nancy Elvira, Pérez, Karla Alejandra, Tur, Josep Antoni, Tecnologia de los Alimentos, Álvarez Fernández, Laura, Vitelli Storelli, Facundo Ezequiel, Rubín García, María, Oricheta García, María Silvia, Bouzas, Cristina, Ruiz Canela, Miguel, Corella, Dolores, Corella, D., Salas Savadó, Jordi, Fitõ, Montserrat, Martínez, Jose Alfredo, Tojal-sierra, Lucas, Wärnberg, Julia, Vioque, Jesus L., Romaguera, D., López Miranda, José, Estruch, Ramón Sarrate, Tinahones, Francisco J., Santos Lozano, José Manuel, Serra Majem, Lluis I, Bueno Cavanillas, Aurora, Martín Sánchez, Vicente, García Fernández, María del Camino, Esteve-luque, Virginia, Delgado-rodríquez, Miguel, Torrego-ellacuría, Macarena, Vidal Cortada, Josep Rafael Cuauhtémoc Acoltzi, Arancio Prieto, Lucía, Daimiel, L. A., Casas, Rosa, García-arellano, Ana, Shyam, Sangeetha, González, José Ignacio, Castañer, Olga, García Ríos, Antonio, Ortiz Díaz, F., Fernández, A. C., Sánchez-villegas, Almudena, Morey, Marga, Cano-ibáñez, Naomi, Sorto Sánchez, Carolina, Bernal López, María Rosa, Bes-rastrollo, Maira, Nishi, Stephanie K., Coltell, Oscar, Zomeño, María Dolores, Peã±a-orihuela, Patricia Judith, Aparicio, D. V., Zulet, María A, Vázquez, Z., Babio, Nancy Elvira, Pérez, Karla Alejandra, and Tur, Josep Antoni
Abstract: [EN]This article aims to estimate the differences in environmental impact (greenhouse gas [GHG] emissions, land use, energy used, acidification and potential eutrophication) after one year of promoting a Mediterranean diet (MD). Methods Baseline and 1-year follow-up data from 5800 participants in the PREDIMED-Plus study were used. Each participant's food intake was estimated using validated semi-quantitative food frequency questionnaires, and the adherence to MD using the Dietary Score. The influence of diet on environmental impact was assessed through the EAT-Lancet Commission tables. The influence of diet on environmental impact was assessed through the EAT-Lancet Commission tables. The association between MD adherence and its environmental impact was calculated using adjusted multivariate linear regression models.

33. Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome

Author: Medicina Preventiva, Díaz-López, Andrés, Díaz López, Andrés, Paz Graniel, Indira, Ruiz, Verónica, Toledo, Estefanía, Becerra Tomás, Nerea, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra Majem, Luís, Bueno Cavanillas, Aurora, Tur, Josep A., Martín Sánchez, Vicente, Pintó, Xavier, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Fernández Villa, Tania, Ros, Emilio, Eguaras, Sonia, Babio, Nancy, Sorlí, José V., Goday, Albert, Abete, Itziar, Tojal Sierra, Lucas, Barón López, Francisco Javier, Torres Collado, Laura, Morey, Marga, García Ríos, Antonio, Casas, Rosa, Bernal López, María Rosa, Santos Lozano, José Manuel, Navarro, Adela, Gonzalez, Jose I., Zomeño, María Dolores, Zulet, Maria Angeles, Vaquero Luna, Jessica, Ramallal, Raul, Fitó, Montse, Salas Salvadó, Jordi, Medicina Preventiva, Díaz-López, Andrés, Díaz López, Andrés, Paz Graniel, Indira, Ruiz, Verónica, Toledo, Estefanía, Becerra Tomás, Nerea, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra Majem, Luís, Bueno Cavanillas, Aurora, Tur, Josep A., Martín Sánchez, Vicente, Pintó, Xavier, Delgado Rodríguez, Miguel, Matía Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Fernández Villa, Tania, Ros, Emilio, Eguaras, Sonia, Babio, Nancy, Sorlí, José V., Goday, Albert, Abete, Itziar, Tojal Sierra, Lucas, Barón López, Francisco Javier, Torres Collado, Laura, Morey, Marga, García Ríos, Antonio, Casas, Rosa, Bernal López, María Rosa, Santos Lozano, José Manuel, Navarro, Adela, Gonzalez, Jose I., Zomeño, María Dolores, Zulet, Maria Angeles, Vaquero Luna, Jessica, Ramallal, Raul, Fitó, Montse, and Salas Salvadó, Jordi
Abstract: [EN] It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and 1-year changes in glomerular filtration rate (eGFR) in a large Spanish cohort of overweight/obese elderly with metabolic syndrome (MetS). This prospective analysis includes 5851 overweight/obese adults (55–75 years) with MetS from the PREDIMED-Plus study. We assessed coffee, tea, and caffeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate-adjusted regression models were applied to test associations between baseline coffee, tea, or caffeine intake and 1-year eGFR changes. Caffeinated coffee (> 2 cups/day) and tea (at least 1 cup/day) drinkers had 0.88 and 0.93 mL/min/1.73 m2 greater eGFR decrease respectively, compared to those with less than 1 cup/day of coffee consumption or non-tea drinkers. Furthermore, caffeinated coffee consumption of > 2 cups/day was associated with 1.19-fold increased risk of rapid eGFR decline > 3 mL/min/1.73 m2 (95% CI 1.01–1.41). Similarly, individuals in the highest (median, 51.2 mg/day) tertile of caffeine intake had a 0.87 mL/min/1.73 m2 greater eGFR decrease. Decaffeinated coffee was not associated with eGFR changes. In conclusion, higher onsumption of caffeinated coffee, tea, and caffeine was associated with a greater 1-year eGFR decline in overweight/obese adults with MetS.

34. Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial.

Author: Díaz-López A, Becerra-Tomás N, Ruiz V, Toledo E, Babio N, Corella D, Fitó M, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Tinahones FJ, Lapetra J, Pintó X, Tur JA, López-Miranda J, Cano Ibañez N, Delgado-Rodríguez M, Matía-Martín P, Daimiel L, de Paz JA, Vidal J, Vázquez C, Ruiz-Canela M, Bulló M, Sorlí JV, Goday A, Fiol M, García-de-la-Hera M, Tojal Sierra L, Pérez-Farinós N, Zulet MÁ, Sánchez-Villegas A, Sacanella E, Fernández-García JC, Santos-Lozano JM, Gimenez-Gracia M, Del Mar Bibiloni M, Diez-Espino J, Ortega-Azorin C, Castañer O, Morey M, Torres-Collado L, Sorto Sanchez C, Muñoz MÁ, Ros E, Martinez-Gonzalez MA, and Salas-Salvadó J
Subjects: Aged, Female, Humans, Kidney Function Tests, Male, Middle Aged, Kidney physiopathology, Life Style, Obesity physiopathology, Obesity therapy, Weight Loss
Abstract: Introduction: Large randomized trials testing the effect of a multifactorial weight-loss lifestyle intervention including Mediterranean diet (MedDiet) on renal function are lacking. Here, we evaluated the 1-year efficacy of an intensive weight-loss intervention with an energy-reduced MedDiet (erMedDiet) plus increased physical activity (PA) on renal function., Methods: Randomized controlled "PREvención con DIeta MEDiterránea-Plus" (PREDIMED-Plus) trial is conducted in 23 Spanish centers comprising 208 primary care clinics. Overweight/obese (n = 6,719) adults aged 55-75 years with metabolic syndrome were randomly assigned (1:1) to an intensive weight-loss lifestyle intervention with an erMedDiet, PA promotion, and behavioral support (intervention) or usual-care advice to adhere to an energy-unrestricted MedDiet (control) between September 2013 and December 2016. The primary outcome was 1-year change in estimated glomerular filtration rate (eGFR). Secondary outcomes were changes in urine albumin-to-creatinine ratio (UACR), incidence of moderately/severely impaired eGFR (<60 mL/min/1.73 m2) and micro- to macroalbuminuria (UACR ≥30 mg/g), and reversion of moderately (45 to <60 mL/min/1.73 m2) to mildly impaired GFR (60 to <90 mL/min/1.73 m2) or micro- to macroalbuminuria., Results: After 1 year, eGFR declined by 0.66 and 1.25 mL/min/1.73 m2 in the intervention and control groups, respectively (mean difference, 0.58 mL/min/1.73 m2; 95% CI: 0.15-1.02). There were no between-group differences in mean UACR or micro- to macroalbuminuria changes. Moderately/severely impaired eGFR incidence and reversion of moderately to mildly impaired GFR were 40% lower (HR 0.60; 0.44-0.82) and 92% higher (HR 1.92; 1.35-2.73), respectively, in the intervention group., Conclusions: The PREDIMED-Plus lifestyle intervention approach may preserve renal function and delay CKD progression in overweight/obese adults., (© 2021 S. Karger AG, Basel.)
Published: 2021
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35. Effect of changes in adherence to Mediterranean diet on nutrient density after 1-year of follow-up: results from the PREDIMED-Plus Study.

Author: Cano-Ibáñez N, Bueno-Cavanillas A, Martínez-González MÁ, Salas-Salvadó J, Corella D, Freixer GL, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Tinahones FJ, Lapetra J, Pintó X, Tur JA, García-Ríos A, García-Molina L, Delgado-Rodríguez M, Matía-Martín P, Daimiel L, Martín-Sánchez V, Vidal J, Vázquez C, Ros E, Bartolomé-Resano J, Palau-Galindo A, Portoles O, Torres L, Miquel-Fiol, Sánchez MTC, Sorto-Sánchez C, Moreno-Morales N, Abete I, Álvarez-Pérez J, Sacanella E, Bernal-López MR, Santos-Lozano JM, Fanlo-Maresma M, Bouzas C, Razquin C, Becerra-Tomás N, Ortega-Azorin C, LLimona R, Morey M, Román-Maciá J, Goicolea-Güemez L, Vázquez-Ruiz Z, Barrubés L, Fitó M, and Gea A
Subjects: Aged, Cardiovascular Diseases complications, Cardiovascular Diseases prevention & control, Female, Follow-Up Studies, Humans, Male, Metabolic Syndrome complications, Metabolic Syndrome prevention & control, Middle Aged, Obesity complications, Obesity prevention & control, Overweight complications, Overweight prevention & control, Risk Factors, Spain, Time Factors, Cardiovascular Diseases diet therapy, Diet, Mediterranean, Metabolic Syndrome diet therapy, Nutritional Status, Obesity diet therapy, Overweight diet therapy
Abstract: Background: The prevalence of overweight/obesity and related manifestations such as metabolic syndrome (MetS) is increasing worldwide. High energy density diets, usually with low nutrient density, are among the main causes. Some high-quality dietary patterns like the Mediterranean diet (MedDiet) have been linked to the prevention and better control of MetS. However, it is needed to show that nutritional interventions promoting the MedDiet are able to improve nutrient intake., Objective: To assess the effect of improving MedDiet adherence on nutrient density after 1 year of follow-up at the PREDIMED-Plus trial., Methods: We assessed 5777 men (55-75 years) and women (60-75 years) with overweight or obesity and MetS at baseline from the PREDIMED-Plus trial. Dietary changes and MedDiet adherence were evaluated at baseline and after 1 year. The primary outcome was the change in nutrient density (measured as nutrient intake per 1000 kcal). Multivariable-adjusted linear regression models were fitted to analyse longitudinal changes in adherence to the MedDiet and concurrent changes in nutrient density., Results: During 1-year follow-up, participants showed improvements in nutrient density for all micronutrients assessed. The density of carbohydrates (- 9.0%), saturated fatty acids (- 10.4%) and total energy intake (- 6.3%) decreased. These changes were more pronounced in the subset of participants with higher improvements in MedDiet adherence., Conclusions: The PREDIMED-Plus dietary intervention, based on MedDiet recommendations for older adults, maybe a feasible strategy to improve nutrient density in Spanish population at high risk of cardiovascular disease with overweight or obesity.
Published: 2020
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36. Cross-sectional association between non-soy legume consumption, serum uric acid and hyperuricemia: the PREDIMED-Plus study.

Author: Becerra-Tomás N, Mena-Sánchez G, Díaz-López A, Martínez-González MÁ, Babio N, Corella D, Freixer G, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Fernández-García JC, Lapetra J, Pintó X, Tur JA, López-Miranda J, Bueno-Cavanillas A, Gaforio JJ, Matía-Martín P, Daimiel L, Martín-Sánchez V, Vidal J, Vázquez C, Ros E, Razquin C, Abellán Cano I, Sorli JV, Torres L, Morey M, Navarrete-Muñoz EM, Tojal Sierra L, Crespo-Oliva E, Zulet MÁ, Sanchez-Villegas A, Casas R, Bernal-Lopez MR, Santos-Lozano JM, Corbella E, Del Mar Bibiloni M, Ruiz-Canela M, Fernández-Carrión R, Quifer M, Prieto RM, Fernandez-Brufal N, Salaverria Lete I, Cenoz JC, Llimona R, and Salas-Salvadó J
Subjects: Aged, Cross-Sectional Studies, Humans, Prevalence, Risk Factors, Uric Acid, Fabaceae, Hyperuricemia epidemiology, Metabolic Syndrome
Abstract: Purpose: To assess the association between the consumption of non-soy legumes and different subtypes of non-soy legumes and serum uric acid (SUA) or hyperuricemia in elderly individuals with overweight or obesity and metabolic syndrome., Methods: A cross-sectional analysis was conducted in the framework of the PREDIMED-Plus study. We included 6329 participants with information on non-soy legume consumption and SUA levels. Non-soy legume consumption was estimated using a semi-quantitative food frequency questionnaire. Linear regression models and Cox regression models were used to assess the associations between tertiles of non-soy legume consumption, different subtypes of non-soy legume consumption and SUA levels or hyperuricemia prevalence, respectively., Results: Individuals in the highest tertile (T3) of total non-soy legume, lentil and pea consumption, had 0.14 mg/dL, 0.19 mg/dL and 0.12 mg/dL lower SUA levels, respectively, compared to those in the lowest tertile (T1), which was considered the reference one. Chickpea and dry bean consumption showed no association. In multivariable models, participants located in the top tertile of total non-soy legumes [prevalence ratio (PR): 0.89; 95% CI 0.82-0.97; p trend = 0.01, lentils (PR: 0.89; 95% CI 0.82-0.97; p trend = 0.01), dry beans (PR: 0.91; 95% C: 0.84-0.99; p trend = 0.03) and peas (PR: 0.89; 95% CI 0.82-0.97; p trend = 0.01)] presented a lower prevalence of hyperuricemia (vs. the bottom tertile). Chickpea consumption was not associated with hyperuricemia prevalence., Conclusions: In this study of elderly subjects with metabolic syndrome, we observed that despite being a purine-rich food, non-soy legumes were inversely associated with SUA levels and hyperuricemia prevalence., Trial Registration: ISRCTN89898870. Registration date: 24 July 2014.
Published: 2020
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