391 results on '"Moretti, V"'
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2. Bell inequality violation by entangled single photon states generated from a laser, a LED or a Halogen lamp
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Pasini, M., Leone, N., Mazzucchi, S., Moretti, V., Pastorello, D., and Pavesi, L.
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Quantum Physics ,Physics - Optics - Abstract
In single-particle or intraparticle entanglement, two degrees of freedom of a single particle, e.g., momentum and polarization of a single photon, are entangled. Single-particle entanglement (SPE) provides a source of non classical correlations which can be exploited both in quantum communication protocols and in experimental tests of noncontextuality based on the Kochen-Specker theorem. Furthermore, SPE is robust under decoherence phenomena. Here, we show that single-particle entangled states of single photons can be produced from attenuated sources of light, even classical ones. To experimentally certify the entanglement, we perform a Bell test, observing a violation of the Clauser, Horne, Shimony and Holt (CHSH) inequality. On the one hand, we show that this entanglement can be achieved even in a classical light beam, provided that first-order coherence is maintained between the degrees of freedom involved in the entanglement. On the other hand, we prove that filtered and attenuated light sources provide a flux of independent SPE photons that, from a statistical point of view, are indistinguishable from those generated by a single photon source. This has important consequences, since it demonstrates that cheap, compact, and low power entangled photon sources can be used for a range of quantum technology applications.
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- 2020
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3. Toward stomatal–flux based forest protection against ozone: The MOTTLES approach
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Paoletti, E., Alivernini, A., Anav, A., Badea, O., Carrari, E., Chivulescu, S., Conte, A., Ciriani, M.L., Dalstein-Richier, L., De Marco, A., Fares, S., Fasano, G., Giovannelli, A., Lazzara, M., Leca, S., Materassi, A., Moretti, V., Pitar, D., Popa, I., Sabatini, F., Salvati, L., Sicard, P., Sorgi, T., and Hoshika, Y.
- Published
- 2019
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4. Cosmological horizons and reconstruction of quantum field theories
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Dappiaggi, C., Moretti, V., and Pinamonti, N.
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory ,Mathematical Physics - Abstract
As a starting point, we state some relevant geometrical properties enjoyed by the cosmological horizon of a certain class of Friedmann-Robertson-Walker backgrounds. Those properties are generalised to a larger class of expanding spacetimes $M$ admitting a geodesically complete cosmological horizon $\scrim$ common to all co-moving observers. This structure is later exploited in order to recast, in a cosmological background, some recent results for a linear scalar quantum field theory in spacetimes asymptotically flat at null infinity. Under suitable hypotheses on $M$, encompassing both the cosmological de Sitter background and a large class of other FRW spacetimes, the algebra of observables for a Klein-Gordon field is mapped into a subalgebra of the algebra of observables $\cW(\scrim)$ constructed on the cosmological horizon. There is exactly one pure quasifree state $\lambda$ on $\cW(\scrim)$ which fulfils a suitable energy-positivity condition with respect to a generator related with the cosmological time displacements. Furthermore $\lambda$ induces a preferred physically meaningful quantum state $\lambda_M$ for the quantum theory in the bulk. If $M$ admits a timelike Killing generator preserving $\scrim$, then the associated self-adjoint generator in the GNS representation of $\lambda_M$ has positive spectrum (i.e. energy). Moreover $\lambda_M$ turns out to be invariant under every symmetry of the bulk metric which preserves the cosmological horizon. In the case of an expanding de Sitter spacetime, $\lambda_M$ coincides with the Euclidean (Bunch-Davies) vacuum state, hence being Hadamard in this case. Remarks on the validity of the Hadamard property for $\lambda_M$ in more general spacetimes are presented., Comment: 32 pages, 1 figure, to appear on Comm. Math. Phys., dedicated to Professor Klaus Fredenhagen on the occasion of his 60th birthday
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- 2007
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5. Quantum out-states holographically induced by asymptotic flatness: Invariance under spacetime symmetries, energy positivity and Hadamard property
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Moretti, V.
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory ,Mathematical Physics - Abstract
This paper continues the analysis of the quantum states determined by the universal asymptotic structure of four-dimensional asymptotically flat vacuum spacetimes at null infinity M. It is now focused on the quantum state lambda_M, of a massles conformally coupled scalar field phi propagating in M. lambda_M is ``holographically'' induced in the bulk by the universal BMS-invariant state lambda at infinity scri of M. It is done by means of the correspondence between observables in the bulk and those on the boundary at null infinity discussed in previous papers. The induction is possible when some requirements are fulfilled, in particular the spacetime M and the associated unphysical one are globally hyperbolic and M admits future time infinity i^+. lambda_M coincides with Minkowski vacuum if M is Minkowski spacetime. It is now proved that, in the general case of a curved spacetime M, the state lambda_M enjoys the following further properties. (1) lambda_M is invariant under the group of isometries of the bulk spacetime M. (2) lambda_M fulfills a natural energy-positivity condition with respect to every notion of Killing time (if any) in the bulk spacetime M: If M admits a complete time-like Killing vector, the associated one-parameter group of isometries is represented by a strongly-continuous unitary group in the GNS representation of lambda_M. The unitary group has positive self-adjoint generator without zero modes in the one-particle space. (3) lambda_M is (globally) Hadamard in M and thus lambda_M can be used as starting point for perturbative renormalization procedure of QFT of phi in M., Comment: 41 pages, 2 figures, references added, presentation of some proofs improved, final version accepted for publication in Commun. Math. Phys
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- 2006
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6. Black Hole Horizons and Thermodynamics: A Quantum Approach
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Moretti, V. and Pinamonti, N.
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory - Abstract
We focus on quantization of the metric of a black hole restricted to the Killing horizon with universal radius $r_0$. After imposing spherical symmetry and after restriction to the Killing horizon, the metric is quantized employing the chiral currents formalism. Two ``components of the metric'' are indeed quantized: The former behaves as an affine scalar field under changes of coordinates, the latter is instead a proper scalar field. The action of the symplectic group on both fields is realized in terms of certain horizon diffeomorphisms. Depending on the choice of the vacuum state, such a representation is unitary. If the reference state of the scalar field is a coherent state rather than a vacuum, spontaneous breaking of conformal symmetry arises and the state contains a Bose-Einstein condensate. In this case the order parameter fixes the actual size of the black hole with respect to $r_0$. Both the constructed state together with the one associated with the affine scalar are thermal states (KMS) with respect to Schwarzschild Killing time when restricted to half horizon. The value of the order parameter fixes the temperature at the Hawking value as well. As a result, it is found that the quantum energy and entropy densities coincide with the black hole mass and entropy, provided the universal parameter $r_0$ is suitably chosen, not depending on the size of the actual black hole in particular., Comment: 21 pages, revised and published version, title changed
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- 2005
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7. Rigorous steps towards holography in asymptotically flat spacetimes
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Dappiaggi, C., Moretti, V., and Pinamonti, N.
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory ,Mathematical Physics - Abstract
Scalar QFT on the boundary $\Im^+$ at null infinity of a general asymptotically flat 4D spacetime is constructed using the algebraic approach based on Weyl algebra associated to a BMS-invariant symplectic form. The constructed theory is invariant under a suitable unitary representation of the BMS group with manifest meaning when the fields are interpreted as suitable extensions to $\Im^+$ of massless minimally coupled fields propagating in the bulk. The analysis of the found unitary BMS representation proves that such a field on $\Im^+$ coincides with the natural wave function constructed out of the unitary BMS irreducible representation induced from the little group $\Delta$, the semidirect product between SO(2) and the two dimensional translational group. The result proposes a natural criterion to solve the long standing problem of the topology of BMS group. Indeed the found natural correspondence of quantum field theories holds only if the BMS group is equipped with the nuclear topology rejecting instead the Hilbert one. Eventually some theorems towards a holographic description on $\Im^+$ of QFT in the bulk are established at level of $C^*$ algebras of fields for strongly asymptotically predictable spacetimes. It is proved that preservation of a certain symplectic form implies the existence of an injective $*$-homomorphism from the Weyl algebra of fields of the bulk into that associated with the boundary $\Im^+$. Those results are, in particular, applied to 4D Minkowski spacetime where a nice interplay between Poincar\'e invariance in the bulk and BMS invariance on the boundary at $\Im^+$ is established at level of QFT. It arises that the $*$-homomorphism admits unitary implementation and Minkowski vacuum is mapped into the BMS invariant vacuum on $\Im^+$., Comment: 62 pages, amslatex, xy package; revised section 2 and the conclusions; corrected some typos; added some references; accepted for pubblication on Rev. Math. Phys
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- 2005
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8. Bose-Einstein condensate and Spontaneous Breaking of Conformal Symmetry on Killing Horizons
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Moretti, V. and Pinamonti, N.
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High Energy Physics - Theory ,General Relativity and Quantum Cosmology ,Mathematical Physics - Abstract
Local scalar QFT (in Weyl algebraic approach) is constructed on degenerate semi-Riemannian manifolds corresponding to Killing horizons in spacetime. Covariance properties of the $C^*$-algebra of observables with respect to the conformal group $PSL(2,\bR)$ are studied.It is shown that, in addition to the state studied by Guido, Longo, Roberts and Verch for bifurcated Killing horizons, which is conformally invariant and KMS at Hawking temperature with respect to the Killing flow and defines a conformal net of von Neumann algebras, there is a further wide class of algebraic (coherent) states representing spontaneous breaking of $PSL(2,\bR)$ symmetry. This class is labeled by functions in a suitable Hilbert space and their GNS representations enjoy remarkable properties. The states are non equivalent extremal KMS states at Hawking temperature with respect to the residual one-parameter subgroup of $PSL(2,\bR)$ associated with the Killing flow. The KMS property is valid for the two local sub algebras of observables uniquely determined by covariance and invariance under the residual symmetry unitarily represented. These algebras rely on the physical region of the manifold corresponding to a Killing horizon cleaned up by removing the unphysical points at infinity (necessary to describe the whole $PSL(2,\bR)$ action).Each of the found states can be interpreted as a different thermodynamic phase, containing Bose-Einstein condensate,for the considered quantum field. It is finally suggested that the found states could describe different black holes., Comment: 36 pages, 1 figure. Formula of condensate energy density modified. Accepted for pubblication in Journal of Mathematical Physics
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- 2004
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9. Quantum Virasoro algebra with central charge c=1 on the horizon of a 2D-Rindler spacetime
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Moretti, V. and Pinamonti, N.
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High Energy Physics - Theory ,General Relativity and Quantum Cosmology ,Mathematical Physics - Abstract
Using the holographic machinery built up in a previous work, we show that the hidden SL(2,R) symmetry of a scalar quantum field propagating in a Rindler spacetime admits an enlargement in terms of a unitary positive-energy representation of Virasoro algebra, with central charge c=1, defined in the Fock representation. The Virasoro algebra of operators gets a manifest geometrical meaning if referring to the holographically associated QFT on the horizon: It is nothing but a representation of the algebra of vector fields defined on the horizon equipped with a point at infinity. All that happens provided the Virasoro ground energy h vanishes and, in that case, the Rindler Hamiltonian is associated with a certain Virasoro generator. If a suitable regularization procedure is employed, for h=1/2, the ground state of that generator corresponds to thermal states when examined in the Rindler wedge, taking the expectation value with respect to Rindler time. This state has inverse temperature 1/(2beta), where beta is the parameter used to define the initial SL(2,R) unitary representation. (As a consequence the restriction of Minkowski vacuum to Rindler wedge is obtained by fixing h=1/2 and 2beta=beta_U, the latter being Unruh's inverse temperature). Finally, under Wick rotation in Rindler time, the pair of QF theories which are built up on the future and past horizon defines a proper two-dimensional conformal quantum field theory on a cylinder., Comment: 35 pages, 1 figure .eps, LaTeX 2e, minor changes, accepted for publication in J.Math.Phys
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- 2003
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10. Holography and $SL(2,\bR)$ symmetry in 2D Rindler spacetime
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Moretti, V. and Pinamonti, N.
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High Energy Physics - Theory ,General Relativity and Quantum Cosmology ,Mathematical Physics - Abstract
It is shown that it is possible to define quantum field theory of a massless scalar free field on the Killing horizon of a 2D-Rindler spacetime. Free quantum field theory on the horizon enjoys diffeomorphism invariance and turns out to be unitarily and algebraically equivalent to the analogous theory of a scalar field propagating inside Rindler spacetime, nomatter the value of the mass of the field in the bulk. More precisely, there exists a unitary transformation that realizes the bulk-boundary correspondence under an appropriate choice for Fock representation spaces. Secondly, the found correspondence is a subcase of an analogous algebraic correspondence described by injective *-homomorphisms of the abstract algebras of observables generated by abstract quantum free-field operators. These field operators are smeared with suitable test functions in the bulk and exact 1-forms on the horizon. In this sense the correspondence is independent from the chosen vacua. It is proven that, under that correspondence the ``hidden'' $SL(2,\bR)$ quantum symmetry found in a previous work gets a clear geometric meaning, it being associated with a group of diffeomorphisms of the horizon itself., Comment: Title changed, further minor changes, references added, accepted for publication in J. Math. Phys
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- 2003
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11. QFT holography near the horizon of Schwarzschild-like spacetimes
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Moretti, V. and Pinamonti, N.
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High Energy Physics - Theory ,General Relativity and Quantum Cosmology - Abstract
It is argued that free QFT can be defined on the event horizon of a Schwarzschild-like spacetime and that this theory is unitarily and algebraically equivalent to QFT in the bulk (near the horizon). Under that unitary equivalence the bulk hidden SL(2,R) symmetry found in a previous work becomes manifest on the event horizon, it being induced by a group of horizon diffeomorphisms. The class of generators of that group can be enlarged to include a full Virasoro algebra of fields which are defined on the event horizon. These generators have a quantum representation in QFT on the event horizon and thus in the bulk., Comment: 8 pages, 1 figure, latex 2e, Relevant references added
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- 2003
12. Aspects of hidden and manifest SL(2,R) symmetry in 2D near-horizon black-hole background
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Moretti, V. and Pinamonti, N.
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory ,Mathematical Physics - Abstract
The invariance under unitary representations of the conformal group SL(2,R) of a quantum particle is rigorously investigated in two-dimensional spacetimes containing Killing horizons using DFF model. The limit of the near-horizon approximation is considered. If the Killing horizon is bifurcate the conformal symmetry is hidden, i.e. it does not arise from geometrical spacetime isometries, but the whole Hilbert space turns out to be an irreducible unitary representation of SL(2,R) and the time evolution is embodied in the unitary representation. In this case the symmetry does not depend on the mass of the particle and, if the representation is faithful, the conformal observable K shows thermal properties. If the Killing horizon is nonbifurcate the conformal symmetry is manifest, i.e. it arises from geometrical spacetime isometries. The SL(2,R) representation which arises from the geometry selects a hidden conformal representation. Also in that case the Hilbert space is an irreducible representation of SL(2,R) and the group conformal symmetries embodies the time evolution with respect to the local Killing time. However no thermal properties are involved. The conformal observable K gives rise to Killing time evolution of the quantum state with respect to another global Killing time present in the manifold. Mathematical proofs about the developed machinery are supplied and features of the operator H_g = -({d^2}/{dx^2})+ ({g}/{x^2}), with g=-1/4 are discussed. It is proven that a statement, used in the recent literature, about the spectrum of self-adjoint extensions of H_g is incorrect., Comment: 22 pages, 1 figure, latex 2e, some misprint corrected, a reference and a footnote added
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- 2002
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13. Aspects of noncommutative Lorentzian geometry for globally hyperbolic spacetimes
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Moretti, V.
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory ,Mathematical Physics - Abstract
Connes' functional formula of the Riemannian distance is generalized to the Lorentzian case using the so-called Lorentzian distance, the d'Alembert operator and the causal functions of a globally hyperbolic spacetime. As a step of the presented machinery, a proof of the almost-everywhere smoothness of the Lorentzian distance considered as a function of one of the two arguments is given. Afterwards, using a $C^*$-algebra approach, the spacetime causal structure and the Lorentzian distance are generalized into noncommutative structures giving rise to a Lorentzian version of part of Connes' noncommutative geometry. The generalized noncommutative spacetime consists of a direct set of Hilbert spaces and a related class of $C^*$-algebras of operators. In each algebra a convex cone made of self-adjoint elements is selected which generalizes the class of causal functions. The generalized events, called {\em loci}, are realized as the elements of the inductive limit of the spaces of the algebraic states on the $C^*$-algebras. A partial-ordering relation between pairs of loci generalizes the causal order relation in spacetime. A generalized Lorentz distance of loci is defined by means of a class of densely-defined operators which play the r\^ole of a Lorentzian metric. Specializing back the formalism to the usual globally hyperbolic spacetime, it is found that compactly-supported probability measures give rise to a non-pointwise extension of the concept of events., Comment: 43 pages, structure of the paper changed and presentation strongly improved, references added, minor typos corrected, title changed, accepted for publication in Reviews in Mathematical Physics
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- 2002
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14. On recent strategies proposed for proving the Riemann hypothesis
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Elizalde, E., Moretti, V., and Zerbini, S.
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Mathematical Physics ,High Energy Physics - Theory ,Mathematics - General Mathematics ,Mathematics - Number Theory ,11M26 ,30B40 ,14G10 ,46E20 - Abstract
We comment on some apparently weak points in the novel strategies recently developed by various authors aiming at a proof of the Riemann hypothesis. After noting the existence of relevant previous papers where similar tools have been used, we refine some of these strategies. It is not clear at the moment if the problems we point out here can be resolved rigorously, and thus a proof of the RH be obtained, along the lines proposed. However, a specific suggestion of a procedure to overcome the encountered difficulties is made, what constitutes a step towards this goal., Comment: 7 pages, LaTeX, no figures
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- 2001
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15. Quantum Scalar Field on the Massless (2+1)-Dimensional Black Hole Background
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Binosi, D., Moretti, V., Vanzo, L., and Zerbini, S.
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory - Abstract
The behavior of a quantum scalar field is studied in the metric ground state of the (2+1)-dimensional black hole of Ba\~nados, Teitelboim and Zanelli which contains a naked singularity. The one-loop BTZ partition function and the associate black hole effective entropy, the expectation value of the quantum fluctuation as well as the renormalized expectation value of the stress tensor are explicitly computed in the framework of the $\zeta$-function procedure. This is done for all values of the coupling with the curvature, the mass of the field and the temperature of the quantum state. In the massless conformally coupled case, the found stress tensor is used for determining the quantum back reaction on the metric due to the scalar field in the quantum vacuum state, by solving the semiclassical Einstein equations. It is finally argued that, within the framework of the 1/N expansion, the Cosmic Censorship Hypothesis is implemented since the naked singularity of the ground state metric is shielded by an event horizon created by the back reaction., Comment: 18 pages, RevTeX, no figures, minor changes, final version accepted for publication in Phys. Rev. D
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- 1998
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16. Rotating Topological Black Holes
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Klemm, D., Moretti, V., and Vanzo, L.
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General Relativity and Quantum Cosmology - Abstract
A class of metrics solving Einstein's equations with negative cosmological constant and representing rotating, topological black holes is presented. All such solutions are in the Petrov type-$D$ class, and can be obtained from the most general metric known in this class by acting with suitably chosen discrete groups of isometries. First, by analytical continuation of the Kerr-de Sitter metric, a solution describing uncharged, rotating black holes whose event horizon is a Riemann surface of arbitrary genus $g > 1$, is obtained. Then a solution representing a rotating, uncharged toroidal black hole is also presented. The higher genus black holes appear to be quite exotic objects, they lack global axial symmetry and have an intricate causal structure. The toroidal blackholes appear to be simpler, they have rotational symmetry and the amount of rotation they can have is bounded by some power of the mass., Comment: 25 pages, LateX, five ps figures added, minor errors corrected, addition of new references, improved discussion of the conserved charges
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- 1997
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17. \zeta function renormalization of one-loop stress tensors in curved spacetime: a check on the method in the conical manifold and other cases
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Moretti, V.
- Subjects
High Energy Physics - Theory ,General Relativity and Quantum Cosmology - Abstract
A previously introduced method to renormalize the one-loop stress tensor and the one-loop vacuum fluctuations in a curved background by a direct local $\zeta$-function approach is checked in some thermal and nonthermal cases. First the method is checked in the case of a conformally coupled massless field in the static Einstein universe where all hypotheses initially requested by the method hold true. Secondly, dropping the hypothesis of a closed manifold, the method is checked in the open static Einstein universe. Finally, the method is checked for a massless scalar field in the presence of a conical singularity in the Euclidean manifold (i.e. Rindler spacetimes/ large mass black hole manifold/cosmic string manifold). In all cases, a complete agreement with other approaches is found. Concerning the last case in particular, the method is proved to give rise to the stress tensor already got by the point-splitting approach for every coupling with the curvature regardless of the presence of the singular curvature. In the last case, comments on the measure employed in the path integral, the use of the optical manifold and the different approaches to renormalize the Hamiltonian are made., Comment: 22 pages, latex, no figures
- Published
- 1997
18. Canonical Quantization of Photons in a Rindler Wedge
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Moretti, V.
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory - Abstract
Photons and thermal photons are studied in the Rindler Wedge employing Feynman's gauge and canonical quantization. A Gupta-Bleuler-like formalism is explicitly implemented. Non thermal Wightman functions and related (Euclidean and Lorentzian) Green functions are explicitly calculated and their complex time analytic structure is analyzed using the Fulling-Ruijsenaars master function. The invariance of the advanced minus retarded fundamental solution is checked and a Ward identity discussed. It is suggested the KMS condition can be implemented to define thermal states also dealing with unphysical photons. Following this way, thermal Wightman functions and related (Euclidean and Lorentzian) Green functions are built up. Their analytic structure is examined employing a thermal master function as in the non thermal case and other corresponding properties are discussed. Some subtleties arising dealing with unphysical photons in presence of the Rindler conical singularity are pointed out. In particular, a family of thermal Wightman and Schwinger functions with the same physical content is proved to exist due to a remaining static gauge ambiguity. A photon version of Bisognano-Wichmann theorem is investigated in the case of photons propagating in the Rindler Wedge employing Wightman functions. Despite of the found ambiguity in defining Rindler Green functions, the coincidence of $(\beta = 2\pi)$-Rindler Wightman functions and Minkowski Wightman functions is proved dealing with test functions related to physical photons and Lorentz photons., Comment: 32 pages, latex, no figures, revised version, no changes in the physical results, to be published in J. Math. Phys
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- 1996
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19. Wightman Functions' Behaviour on the Event Horizon of an Extremal Reissner-Nordstr\'om Black Hole
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Moretti, V.
- Subjects
High Energy Physics - Theory ,General Relativity and Quantum Cosmology - Abstract
A weaker Haag, Narnhofer and Stein prescription as well as a weaker Hessling Quantum Equivalence Principle for the behaviour of thermal Wightman functions on an event horizon are analysed in the case of an extremal Reissner-Nordstr\"{o}m black hole in the limit of a large mass. In order to avoid the degeneracy of the metric in the stationary coordinates on the horizon, a method is introduced which employs the invariant length of geodesics which pass the horizon. First the method is checked for a massless scalar field on the event horizon of the Rindler wedge, extending the original procedure of Haag, Narnhofer and Stein onto the {\em whole horizon} and recovering the same results found by Hessling. Afterwards the HNS prescription and Hessling's prescription for a massless scalar field are analysed on the whole horizon of an extremal Reissner-Nordstr\"{o}m black hole in the limit of a large mass. It is proved that the weak form of the HNS prescription is satisfyed for all the finite values of the temperature of the KMS states, i.e., this principle does not determine any Hawking temperature. It is found that the Reissner-Nordstr\"{o}m vacuum, i.e., $T=0$ does satisfy the weak HNS prescription and it is the only state which satisfies weak Hessling's prescription, too. Finally, it is suggested that all the previously obtained results should be valid dropping the requirements of a massless field and of a large mass black hole., Comment: 27 pages, standard LaTex, no figures, final version containing the results following from Hessling's principle as they appeared in the other paper gr-qc/9510016, minor changes in the text and in references, it will appear on Class. Quant. Grav
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- 1995
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20. Slice Functional Calculus in Quaternionic Hilbert Spaces
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Ghiloni, R., Moretti, V., Perotti, A., Mityushev, Vladimir V., editor, and Ruzhansky, Michael V., editor
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- 2015
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21. Occurrence of L1M Elements in Chromosomal Rearrangements Associated to Chronic Myeloid Leukemia (CML): Insights from Patient-Specific Breakpoints Characterization
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L’Abbate, A, Moretti, V, Pungolino, E, Micheloni, G, Valli, R, Frattini, A, Barcella, M, Acquati, F, A Reinbold, R, Costantino, L, Ferrara, F, Trojani, A, Ventura, M, Porta, G, Cairoli, R, Alberto L’Abbate, Vittoria Moretti, Ester Pungolino, Giovanni Micheloni, Roberto Valli, Annalisa Frattini, Matteo Barcella, Francesco Acquati, Rolland A Reinbold, Lucy Costantino, Fulvio Ferrara, Alessandra Trojani, Mario Ventura, Giovanni Porta, Roberto Cairoli, L’Abbate, A, Moretti, V, Pungolino, E, Micheloni, G, Valli, R, Frattini, A, Barcella, M, Acquati, F, A Reinbold, R, Costantino, L, Ferrara, F, Trojani, A, Ventura, M, Porta, G, Cairoli, R, Alberto L’Abbate, Vittoria Moretti, Ester Pungolino, Giovanni Micheloni, Roberto Valli, Annalisa Frattini, Matteo Barcella, Francesco Acquati, Rolland A Reinbold, Lucy Costantino, Fulvio Ferrara, Alessandra Trojani, Mario Ventura, Giovanni Porta, and Roberto Cairoli
- Abstract
Chronic myeloid leukemia (CML) is a rare myeloproliferative disorder caused by the reciprocal translocation t(9;22)(q34;q11) in hematopoietic stem cells (HSCs). This chromosomal translocation results in the formation of an extra-short chromosome 22, called a Philadelphia chromosome (Ph), containing the BCR-ABL1 fusion gene responsible for the expression of a constitutively active tyrosine kinase that causes uncontrolled growth and replication of leukemic cells. Mechanisms behind the formation of this chromosomal rearrangement are not well known, even if, as observed in tumors, repetitive DNA may be involved as core elements in chromosomal rearrangements. We have participated in the explorative investigations of the PhilosoPhi34 study to evaluate residual Ph+ cells in patients with negative FISH analysis on CD34+/lin- cells with gDNA qPCR. Using targeted next-generation deep sequencing strategies, we analyzed the genomic region around the t(9;22) translocations of 82 CML patients and one CML cell line and assessed the relevance of interspersed repeat elements at breakpoints (BP). We found a statistically higher presence of LINE elements, in particular belonging to the subfamily L1M, in BP cluster regions of both chromosome 22 and 9 compared to the whole human genome. These data suggest that L1M elements could be potential drivers of t(9;22) translocation leading to the generation of the BCR-ABL1 chimeric gene and the expression of the active BCR-ABL1-controlled tyrosine kinase chimeric protein responsible for CML.
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- 2023
22. La co-produzione di servizi in sanità. Una scoping review
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Giarelli G., Genova A, Moretti V., Lombi, Linda, Cervia, S., Lombi L. (ORCID:0000-0002-8486-1021), Giarelli G., Genova A, Moretti V., Lombi, Linda, Cervia, S., and Lombi L. (ORCID:0000-0002-8486-1021)
- Abstract
Il contributo propone i risultati di una sco-ping review orientata a identificare e mappare le evidenze disponibili relati-vamente alle pratiche di co-produzione di servizi in ambito sanitario, per chiarire concetti chiave/definizioni presenti in letteratura, esaminare gli ap-procci metodologici attraverso cui sono condotti gli studi ed esplorare i ri-sultati principali identificando le raccomandazioni in un dato campo
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- 2023
23. Fare ricerca partecipativa su benessere e salute nella società sindemica
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Giarelli, G, Genova, A, Moretti, V, Russo, C, Giarelli, G, Genova, A, Moretti, V, and Russo, C
- Abstract
Partendo dalla definizione di sociologia pubblica proposta da Michael Burawoy (2005), che ragiona sia sulla diffusione della conoscenza sociologica a un pubblico extra accademico, che sulla tensione fra interesse scientifico e interesse pubblico e sociale, questo capitolo vuole discutere l’opportunità dell’utilizzo di un approccio partecipativo e collaborativo alla ricerca sociale, e in particolare a quel ramo della ricerca sociale che si occupa di benessere e salute degli individui. Nei successivi paragrafi, si procederà dunque a definire la ricerca partecipativa e il milieu accademico in cui si è sviluppata, per poi individuarne i principali modelli epistemici. Infine, per rendere più chiaro in che modo questi modelli possano essere operativizzati all’interno della ricerca sociale, si citeranno due esempi di impiego di un approccio collaborativo in due diversi contesti: un reparto ospedaliero e un gruppo di giovani senza fissa dimora.
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- 2023
24. Addressing digital inclusion in the co-design of an e-learning platforms for home caregivers
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Pronzano, R., Moretti, V., Chirico, I., Golino, A., Grignoli, D., Santini, S., and Chattat, R.
- Published
- 2023
25. Comparing Long-Acting Antipsychotic Discontinuation Rates Under Ordinary Clinical Circumstances: A Survival Analysis from an Observational, Pragmatic Study
- Author
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Bertolini, F, Ostuzzi, G, Pievani, M, Aguglia, A, Bartoli, F, Bortolaso, P, Callegari, C, Caroleo, M, Carra, G, Corbo, M, D'Agostino, A, De Fazio, P, Magliocco, F, Martinotti, G, Ostinelli, E, Piccinelli, M, Tedeschi, F, Barbui, C, Boschello, F, Gastaldon, C, Mazzi, M, Nose, M, Papola, D, Perini, G, Piccoli, A, Purgato, M, Ruggeri, M, Terlizzi, S, Turrini, G, Raffaele, G, Cavallotti, S, Chirico, M, Ferrato, F, Limosani, I, Mastromo, D, Monzani, E, Porcellana, M, Restaino, F, Annese, P, Bolognesi, S, Cerretini, M, De Capua, A, Debolini, S, Del Zanna, M, Fargnoli, F, Giannini, A, Luccarelli, L, Lucii, C, Pierantozzi, E, Tozzi, F, Bardicchia, F, Cardamone, G, Facchi, E, Magnani, N, Soscia, F, Biancosino, B, Zotos, S, Giacomin, M, Pompei, F, Spano, M, Zonta, F, Buzzi, A, Calzolari, R, Caselli, I, Diurni, M, Giana, E, Ielmini, M, Milano, A, Poloni, N, Sani, E, Zizolfi, D, Alberini, G, Cazzamalli, S, Costantini, C, Di Caro, A, Paronelli, C, Piantanida, S, Alessandro, P, Barbanti, S, D'Ippolito, C, Gozzi, M, Moretti, V, Campese, O, Di Capro, L, di Giannantonio, M, Fiori, F, Lorusso, M, Mancini, V, Viceconte, D, Calandra, C, Luca, M, Signorelli, M, Suraniti, F, Balzarro, B, Boncompagni, G, Caretto, V, Emiliani, R, Lupoli, P, Menchetti, M, Rossi, E, Storbini, V, Tarricone, I, Terzi, L, Boso, M, Catania, C, De Paoli, G, Risaro, P, Aspesi, F, Bava, M, Bono, A, Brambilla, G, Castagna, G, Lucchi, S, Nava, R, Provenzi, M, Tabacchi, T, Tremolada, M, Verrengia, E, Barchiesi, M, Oriani, M, Pacetti, M, Ferro, M, Ghio, L, Beneduce, R, Laffranchini, L, Magni, L, Rossi, G, Tura, G, Addeo, L, Balletta, G, De Vivo, E, Di Benedetto, R, Parise, V, Carpiniello, B, Pinna, F, Pecile, D, Mattei, C, Bonavigo, T, Fabrici, E, Panarello, S, Peresson, G, Vitucci, C, Gardellin, F, Strizzolo, S, Cossetta, E, Fizzotti, C, Moretti, D, Di Gregorio, L, Sozzi, F, Colli, G, La Barbera, D, Laurenzi, S, Bertolini F., Ostuzzi G., Pievani M., Aguglia A., Bartoli F., Bortolaso P., Callegari C., Caroleo M., Carra G., Corbo M., D'Agostino A., De Fazio P., Magliocco F., Martinotti G., Ostinelli E. G., Piccinelli M. P., Tedeschi F., Barbui C., Boschello F., Gastaldon C., Mazzi M. A., Nose M., Papola D., Perini G., Piccoli A., Purgato M., Ruggeri M., Terlizzi S., Turrini G., Raffaele G., Cavallotti S., Chirico M., Ferrato F., Limosani I., Mastromo D., Monzani E., Porcellana M., Restaino F., Annese P. M., Bolognesi S., Cerretini M., De Capua A., Debolini S., Del Zanna M., Fargnoli F., Giannini A., Luccarelli L., Lucii C., Pierantozzi E., Tozzi F., Bardicchia F., Cardamone G., Facchi E., Magnani N., Soscia F., Biancosino B., Zotos S., Giacomin M., Pompei F., Spano M., Zonta F., Buzzi A., Calzolari R., Caselli I., Diurni M., Giana E., Ielmini M., Milano A., Poloni N., Sani E., Zizolfi D., Alberini G., Cazzamalli S., Costantini C., Di Caro A., Paronelli C., Piantanida S., Piccinelli M., Alessandro P., Barbanti S. V., D'Ippolito C., Gozzi M., Moretti V., Campese O., Di Capro L., di Giannantonio M., Fiori F., Lorusso M., Mancini V., Viceconte D., Calandra C., Luca M., Signorelli M. S., Suraniti F., Balzarro B., Boncompagni G., Caretto V., Emiliani R., Lupoli P., Menchetti M., Rossi E., Storbini V., Tarricone I., Terzi L., Boso M., Catania C., De Paoli G., Risaro P., Aspesi F., Bava M., Bono A., Brambilla G., Castagna G., Lucchi S., Nava R., Provenzi M., Tabacchi T., Tremolada M., Verrengia E., Barchiesi M., Oriani M. G., Pacetti M., Ferro M., Ghio L., Beneduce R., Laffranchini L., Magni L. R., Rossi G., Tura G. B., Addeo L., Balletta G., De Vivo E., Di Benedetto R., Parise V. F., Carpiniello B., Pinna F., Pecile D., Mattei C., Bonavigo T., Fabrici E. P., Panarello S., Peresson G., Vitucci C., Gardellin F., Strizzolo S., Cossetta E., Fizzotti C., Moretti D., Di Gregorio L., Sozzi F., Colli G., La Barbera D., Laurenzi S., Bertolini, F, Ostuzzi, G, Pievani, M, Aguglia, A, Bartoli, F, Bortolaso, P, Callegari, C, Caroleo, M, Carra, G, Corbo, M, D'Agostino, A, De Fazio, P, Magliocco, F, Martinotti, G, Ostinelli, E, Piccinelli, M, Tedeschi, F, Barbui, C, Boschello, F, Gastaldon, C, Mazzi, M, Nose, M, Papola, D, Perini, G, Piccoli, A, Purgato, M, Ruggeri, M, Terlizzi, S, Turrini, G, Raffaele, G, Cavallotti, S, Chirico, M, Ferrato, F, Limosani, I, Mastromo, D, Monzani, E, Porcellana, M, Restaino, F, Annese, P, Bolognesi, S, Cerretini, M, De Capua, A, Debolini, S, Del Zanna, M, Fargnoli, F, Giannini, A, Luccarelli, L, Lucii, C, Pierantozzi, E, Tozzi, F, Bardicchia, F, Cardamone, G, Facchi, E, Magnani, N, Soscia, F, Biancosino, B, Zotos, S, Giacomin, M, Pompei, F, Spano, M, Zonta, F, Buzzi, A, Calzolari, R, Caselli, I, Diurni, M, Giana, E, Ielmini, M, Milano, A, Poloni, N, Sani, E, Zizolfi, D, Alberini, G, Cazzamalli, S, Costantini, C, Di Caro, A, Paronelli, C, Piantanida, S, Alessandro, P, Barbanti, S, D'Ippolito, C, Gozzi, M, Moretti, V, Campese, O, Di Capro, L, di Giannantonio, M, Fiori, F, Lorusso, M, Mancini, V, Viceconte, D, Calandra, C, Luca, M, Signorelli, M, Suraniti, F, Balzarro, B, Boncompagni, G, Caretto, V, Emiliani, R, Lupoli, P, Menchetti, M, Rossi, E, Storbini, V, Tarricone, I, Terzi, L, Boso, M, Catania, C, De Paoli, G, Risaro, P, Aspesi, F, Bava, M, Bono, A, Brambilla, G, Castagna, G, Lucchi, S, Nava, R, Provenzi, M, Tabacchi, T, Tremolada, M, Verrengia, E, Barchiesi, M, Oriani, M, Pacetti, M, Ferro, M, Ghio, L, Beneduce, R, Laffranchini, L, Magni, L, Rossi, G, Tura, G, Addeo, L, Balletta, G, De Vivo, E, Di Benedetto, R, Parise, V, Carpiniello, B, Pinna, F, Pecile, D, Mattei, C, Bonavigo, T, Fabrici, E, Panarello, S, Peresson, G, Vitucci, C, Gardellin, F, Strizzolo, S, Cossetta, E, Fizzotti, C, Moretti, D, Di Gregorio, L, Sozzi, F, Colli, G, La Barbera, D, Laurenzi, S, Bertolini F., Ostuzzi G., Pievani M., Aguglia A., Bartoli F., Bortolaso P., Callegari C., Caroleo M., Carra G., Corbo M., D'Agostino A., De Fazio P., Magliocco F., Martinotti G., Ostinelli E. G., Piccinelli M. P., Tedeschi F., Barbui C., Boschello F., Gastaldon C., Mazzi M. A., Nose M., Papola D., Perini G., Piccoli A., Purgato M., Ruggeri M., Terlizzi S., Turrini G., Raffaele G., Cavallotti S., Chirico M., Ferrato F., Limosani I., Mastromo D., Monzani E., Porcellana M., Restaino F., Annese P. M., Bolognesi S., Cerretini M., De Capua A., Debolini S., Del Zanna M., Fargnoli F., Giannini A., Luccarelli L., Lucii C., Pierantozzi E., Tozzi F., Bardicchia F., Cardamone G., Facchi E., Magnani N., Soscia F., Biancosino B., Zotos S., Giacomin M., Pompei F., Spano M., Zonta F., Buzzi A., Calzolari R., Caselli I., Diurni M., Giana E., Ielmini M., Milano A., Poloni N., Sani E., Zizolfi D., Alberini G., Cazzamalli S., Costantini C., Di Caro A., Paronelli C., Piantanida S., Piccinelli M., Alessandro P., Barbanti S. V., D'Ippolito C., Gozzi M., Moretti V., Campese O., Di Capro L., di Giannantonio M., Fiori F., Lorusso M., Mancini V., Viceconte D., Calandra C., Luca M., Signorelli M. S., Suraniti F., Balzarro B., Boncompagni G., Caretto V., Emiliani R., Lupoli P., Menchetti M., Rossi E., Storbini V., Tarricone I., Terzi L., Boso M., Catania C., De Paoli G., Risaro P., Aspesi F., Bava M., Bono A., Brambilla G., Castagna G., Lucchi S., Nava R., Provenzi M., Tabacchi T., Tremolada M., Verrengia E., Barchiesi M., Oriani M. G., Pacetti M., Ferro M., Ghio L., Beneduce R., Laffranchini L., Magni L. R., Rossi G., Tura G. B., Addeo L., Balletta G., De Vivo E., Di Benedetto R., Parise V. F., Carpiniello B., Pinna F., Pecile D., Mattei C., Bonavigo T., Fabrici E. P., Panarello S., Peresson G., Vitucci C., Gardellin F., Strizzolo S., Cossetta E., Fizzotti C., Moretti D., Di Gregorio L., Sozzi F., Colli G., La Barbera D., and Laurenzi S.
- Abstract
Background: Recent guidelines suggested a wider use of long-acting injectable antipsychotics (LAI) than previously, but naturalistic data on the consequences of LAI use in terms of discontinuation rates and associated factors are still sparse, making it hard for clinicians to be informed on plausible treatment courses. Objective: Our objective was to assess, under real-world clinical circumstances, LAI discontinuation rates over a period of 12 months after a first prescription, reasons for discontinuation, and associated factors. Methods: The STAR Network ‘Depot Study’ was a naturalistic, multicentre, observational prospective study that enrolled subjects initiating a LAI without restrictions on diagnosis, clinical severity or setting. Participants from 32 Italian centres were assessed at baseline and at 6 and 12 months of follow-up. Psychopathology, drug attitude and treatment adherence were measured using the Brief Psychiatric Rating Scale, the Drug Attitude Inventory and the Kemp scale, respectively. Results: The study followed 394 participants for 12 months. The overall discontinuation rate at 12 months was 39.3% (95% confidence interval [CI] 34.4–44.3), with paliperidone LAI being the least discontinued LAI (33.9%; 95% CI 25.3–43.5) and olanzapine LAI the most discontinued (62.5%; 95% CI 35.4–84.8). The most frequent reason for discontinuation was onset of adverse events (32.9%; 95% CI 25.6–40.9) followed by participant refusal of the medication (20.6%; 95% CI 14.6–27.9). Medication adherence at baseline was negatively associated with discontinuation risk (hazard ratio [HR] 0.853; 95% CI 0.742–0.981; p = 0.026), whereas being prescribed olanzapine LAI was associated with increased discontinuation risk compared with being prescribed paliperidone LAI (HR 2.156; 95% CI 1.003–4.634; p = 0.049). Conclusions: Clinicians should be aware that LAI discontinuation is a frequent occurrence. LAI choice should be carefully discussed with the patient, tak
- Published
- 2021
26. Digital Health Literacy and Infodemic: the impact on Italian medical students between 2019-2020
- Author
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Moretti, V, primary, Arnoldo, L, additional, Valdi, G, additional, Conte, A, additional, Masoni, M, additional, Guelfi, MR, additional, Anelli, F, additional, and Brunelli, L, additional
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- 2022
- Full Text
- View/download PDF
27. A dietary intervention study to reduce Metabolic Syndrome risks in heart-transplanted patients
- Author
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Valdi, G, primary, Ferrara, V, additional, Marinoni, M, additional, Nalli, C, additional, Di Nora, C, additional, Sponga, S, additional, Benedetti, G, additional, Parpinel, M, additional, Livi, U, additional, and Moretti, V, additional
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- 2022
- Full Text
- View/download PDF
28. Comparing Long-Acting Antipsychotic Discontinuation Rates Under Ordinary Clinical Circumstances: A Survival Analysis from an Observational, Pragmatic Study
- Author
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Bertolini, F., Ostuzzi, G., Pievani, M., Aguglia, A., Bartoli, F., Bortolaso, P., Callegari, C., Caroleo, M., Carra, G., Corbo, M., D'Agostino, A., De Fazio, P., Magliocco, F., Martinotti, G., Ostinelli, E. G., Piccinelli, M. P., Tedeschi, F., Barbui, C., Boschello, F., Gastaldon, C., Mazzi, M. A., Nose, M., Papola, D., Perini, G., Piccoli, A., Purgato, M., Ruggeri, M., Terlizzi, S., Turrini, G., Raffaele, G., Cavallotti, S., Chirico, M., Ferrato, F., Limosani, I., Mastromo, D., Monzani, E., Porcellana, M., Restaino, F., Annese, P. M., Bolognesi, S., Cerretini, M., De Capua, A., Debolini, S., Del Zanna, M., Fargnoli, F., Giannini, A., Luccarelli, L., Lucii, C., Pierantozzi, E., Tozzi, F., Bardicchia, F., Cardamone, G., Facchi, E., Magnani, N., Soscia, F., Biancosino, B., Zotos, S., Giacomin, M., Pompei, F., Spano, M., Zonta, F., Buzzi, A., Callegred, C., Calzolari, R., Caselli, I., Diurni, M., Giana, E., Ielmini, M., Milano, A., Poloni, N., Sani, E., Zizolfi, D., Alberini, G., Cazzamalli, S., Costantini, C., Di Caro, A., Paronelli, C., Piantanida, S., Piccinelli, M., Alessandro, P., Barbanti, S. V., D'Ippolito, C., Gozzi, M., Moretti, V., Campese, O., Di Capro, L., di Giannantonio, M., Fiori, F., Lorusso, M., Mancini, V., Viceconte, D., Calandra, C., Luca, M., Signorelli, M. S., Suraniti, F., Balzarro, B., Boncompagni, G., Caretto, V., Emiliani, R., Lupoli, P., Menchetti, M., Rossi, E., Storbini, V., Tarricone, I., Terzi, L., Boso, M., Catania, C., De Paoli, G., Risaro, P., Aspesi, F., Bava, M., Bono, A., Brambilla, G., Castagna, G., Lucchi, S., Nava, R., Provenzi, M., Tabacchi, T., Tremolada, M., Verrengia, E., Barchiesi, M., Oriani, M. G., Pacetti, M., Ferro, M., Ghio, L., Beneduce, R., Laffranchini, L., Magni, L. R., Rossi, G., Tura, G. B., Addeo, L., Balletta, G., De Vivo, E., Di Benedetto, R., Parise, V. F., Carpiniello, B., Pinna, F., Pecile, D., Mattei, C., Bonavigo, T., Fabrici, E. P., Panarello, S., Peresson, G., Vitucci, C., Gardellin, F., Strizzolo, S., Cossetta, E., Fizzotti, C., Moretti, D., Di Gregorio, L., Sozzi, F., Colli, G., La Barbera, D., Laurenzi, S., Bertolini, F, Ostuzzi, G, Pievani, M, Aguglia, A, Bartoli, F, Bortolaso, P, Callegari, C, Caroleo, M, Carra, G, Corbo, M, D'Agostino, A, De Fazio, P, Magliocco, F, Martinotti, G, Ostinelli, E, Piccinelli, M, Tedeschi, F, Barbui, C, Boschello, F, Gastaldon, C, Mazzi, M, Nose, M, Papola, D, Perini, G, Piccoli, A, Purgato, M, Ruggeri, M, Terlizzi, S, Turrini, G, Raffaele, G, Cavallotti, S, Chirico, M, Ferrato, F, Limosani, I, Mastromo, D, Monzani, E, Porcellana, M, Restaino, F, Annese, P, Bolognesi, S, Cerretini, M, De Capua, A, Debolini, S, Del Zanna, M, Fargnoli, F, Giannini, A, Luccarelli, L, Lucii, C, Pierantozzi, E, Tozzi, F, Bardicchia, F, Cardamone, G, Facchi, E, Magnani, N, Soscia, F, Biancosino, B, Zotos, S, Giacomin, M, Pompei, F, Spano, M, Zonta, F, Buzzi, A, Calzolari, R, Caselli, I, Diurni, M, Giana, E, Ielmini, M, Milano, A, Poloni, N, Sani, E, Zizolfi, D, Alberini, G, Cazzamalli, S, Costantini, C, Di Caro, A, Paronelli, C, Piantanida, S, Alessandro, P, Barbanti, S, D'Ippolito, C, Gozzi, M, Moretti, V, Campese, O, Di Capro, L, di Giannantonio, M, Fiori, F, Lorusso, M, Mancini, V, Viceconte, D, Calandra, C, Luca, M, Signorelli, M, Suraniti, F, Balzarro, B, Boncompagni, G, Caretto, V, Emiliani, R, Lupoli, P, Menchetti, M, Rossi, E, Storbini, V, Tarricone, I, Terzi, L, Boso, M, Catania, C, De Paoli, G, Risaro, P, Aspesi, F, Bava, M, Bono, A, Brambilla, G, Castagna, G, Lucchi, S, Nava, R, Provenzi, M, Tabacchi, T, Tremolada, M, Verrengia, E, Barchiesi, M, Oriani, M, Pacetti, M, Ferro, M, Ghio, L, Beneduce, R, Laffranchini, L, Magni, L, Rossi, G, Tura, G, Addeo, L, Balletta, G, De Vivo, E, Di Benedetto, R, Parise, V, Carpiniello, B, Pinna, F, Pecile, D, Mattei, C, Bonavigo, T, Fabrici, E, Panarello, S, Peresson, G, Vitucci, C, Gardellin, F, Strizzolo, S, Cossetta, E, Fizzotti, C, Moretti, D, Di Gregorio, L, Sozzi, F, Colli, G, La Barbera, D, Laurenzi, S, Bertolini F., Ostuzzi G., Pievani M., Aguglia A., Bartoli F., Bortolaso P., Callegari C., Caroleo M., Carra G., Corbo M., D'Agostino A., De Fazio P., Magliocco F., Martinotti G., Ostinelli E.G., Piccinelli M.P., Tedeschi F., Barbui C., Boschello F., Gastaldon C., Mazzi M.A., Nose M., Papola D., Perini G., Piccoli A., Purgato M., Ruggeri M., Terlizzi S., Turrini G., Raffaele G., Cavallotti S., Chirico M., Ferrato F., Limosani I., Mastromo D., Monzani E., Porcellana M., Restaino F., Annese P.M., Bolognesi S., Cerretini M., De Capua A., Debolini S., Del Zanna M., Fargnoli F., Giannini A., Luccarelli L., Lucii C., Pierantozzi E., Tozzi F., Bardicchia F., Cardamone G., Facchi E., Magnani N., Soscia F., Biancosino B., Zotos S., Giacomin M., Pompei F., Spano M., Zonta F., Buzzi A., Callegred C., Calzolari R., Caselli I., Diurni M., Giana E., Ielmini M., Milano A., Poloni N., Sani E., Zizolfi D., Alberini G., Cazzamalli S., Costantini C., Di Caro A., Paronelli C., Piantanida S., Piccinelli M., Alessandro P., Barbanti S.V., D'Ippolito C., Gozzi M., Moretti V., Campese O., Di Capro L., di Giannantonio M., Fiori F., Lorusso M., Mancini V., Viceconte D., Calandra C., Luca M., Signorelli M.S., Suraniti F., Balzarro B., Boncompagni G., Caretto V., Emiliani R., Lupoli P., Menchetti M., Rossi E., Storbini V., Tarricone I., Terzi L., Boso M., Catania C., De Paoli G., Risaro P., Aspesi F., Bava M., Bono A., Brambilla G., Castagna G., Lucchi S., Nava R., Provenzi M., Tabacchi T., Tremolada M., Verrengia E., Barchiesi M., Oriani M.G., Pacetti M., Ferro M., Ghio L., Beneduce R., Laffranchini L., Magni L.R., Rossi G., Tura G.B., Addeo L., Balletta G., De Vivo E., Di Benedetto R., Parise V.F., Carpiniello B., Pinna F., Pecile D., Mattei C., Bonavigo T., Fabrici E.P., Panarello S., Peresson G., Vitucci C., Gardellin F., Strizzolo S., Cossetta E., Fizzotti C., Moretti D., Di Gregorio L., Sozzi F., Colli G., La Barbera D., and Laurenzi S.
- Subjects
Male ,Pediatrics ,respectively) ,0302 clinical medicine ,Delayed-Action Preparation ,Brief Psychiatric Rating Scale ,Pharmacology (medical) ,he STAR Network ‘Depot Study’ prospectively followed 394 subjects initiating treatment with long-acting injections (LAIs) of antipsychotics under naturalistic conditions for 12 months. LAI discontinuation was frequent in everyday clinical practice in Italy ,Original Research Article ,Prospective Studies ,Prospective cohort study ,treatment ,Mental Disorders ,Hazard ratio ,whereas more than half of participants initiating risperidone LAI and olanzapine LAI discontinued during the 12 months of follow-up (51.4 and 62.5% ,Psychiatric Status Rating Scale ,Middle Aged ,side efects ,Psychiatry and Mental health ,Italy ,Mental Disorder ,Female ,he STAR Network ‘Depot Study’ prospectively followed 394 subjects initiating treatment with long-acting injections (LAIs) of antipsychotics under naturalistic conditions for 12 months. LAI discontinuation was frequent in everyday clinical practice in Italy, occurring in almost 40% of the entire sample ,side efects, participant refusal to continue LAIs and LAIs no longer being required were the most frequently reported reasons for discontinuation. Paliperidone LAI and aripiprazole LAI were the least discontinued medications (33.9 and 35.4%, respectively), whereas more than half of participants initiating risperidone LAI and olanzapine LAI discontinued during the 12 months of follow-up (51.4 and 62.5%, respectively). In multivariate analysis, being prescribed olanzapine LAI and poor medication adherence at baseline were signifcantly associated with higher discontinuation risk ,Human ,Antipsychotic Agents ,medicine.drug ,Psychopathology ,Adult ,medicine.medical_specialty ,Discontinuation ,Follow-Up Studie ,Medication Adherence ,03 medical and health sciences ,medicine ,Humans ,Paliperidone ,Adverse effect ,Settore MED/25 - Psichiatria ,discontinuation rates ,Psychiatric Status Rating Scales ,respectively). In multivariate analysis ,business.industry ,Long-Acting Antipsychotic ,long-acting injectable antipsychotics ,Survival Analysis ,Confidence interval ,participant refusal to continue LAIs and LAIs no longer being required were the most frequently reported reasons for discontinuation. Paliperidone LAI and aripiprazole LAI were the least discontinued medications (33.9 and 35.4% ,030227 psychiatry ,Prospective Studie ,Antipsychotic Agent ,occurring in almost 40% of the entire sample ,Delayed-Action Preparations ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,being prescribed olanzapine LAI and poor medication adherence at baseline were signifcantly associated with higher discontinuation risk ,Follow-Up Studies - Abstract
Background Recent guidelines suggested a wider use of long-acting injectable antipsychotics (LAI) than previously, but naturalistic data on the consequences of LAI use in terms of discontinuation rates and associated factors are still sparse, making it hard for clinicians to be informed on plausible treatment courses. Objective Our objective was to assess, under real-world clinical circumstances, LAI discontinuation rates over a period of 12 months after a first prescription, reasons for discontinuation, and associated factors. Methods The STAR Network ‘Depot Study’ was a naturalistic, multicentre, observational prospective study that enrolled subjects initiating a LAI without restrictions on diagnosis, clinical severity or setting. Participants from 32 Italian centres were assessed at baseline and at 6 and 12 months of follow-up. Psychopathology, drug attitude and treatment adherence were measured using the Brief Psychiatric Rating Scale, the Drug Attitude Inventory and the Kemp scale, respectively. Results The study followed 394 participants for 12 months. The overall discontinuation rate at 12 months was 39.3% (95% confidence interval [CI] 34.4–44.3), with paliperidone LAI being the least discontinued LAI (33.9%; 95% CI 25.3–43.5) and olanzapine LAI the most discontinued (62.5%; 95% CI 35.4–84.8). The most frequent reason for discontinuation was onset of adverse events (32.9%; 95% CI 25.6–40.9) followed by participant refusal of the medication (20.6%; 95% CI 14.6–27.9). Medication adherence at baseline was negatively associated with discontinuation risk (hazard ratio [HR] 0.853; 95% CI 0.742–0.981; p = 0.026), whereas being prescribed olanzapine LAI was associated with increased discontinuation risk compared with being prescribed paliperidone LAI (HR 2.156; 95% CI 1.003–4.634; p = 0.049). Conclusions Clinicians should be aware that LAI discontinuation is a frequent occurrence. LAI choice should be carefully discussed with the patient, taking into account individual characteristics and possible obstacles related to the practicalities of each formulation. Supplementary Information The online version contains supplementary material available at 10.1007/s40263-021-00809-w.
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- 2021
29. A Review of Recent Results of the ζ-Function Regularization Procedure in Curved Spacetime
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Moretti, V., Casciaro, B., editor, Fortunato, D., editor, Francaviglia, M., editor, and Masiello, A., editor
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- 2000
- Full Text
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30. Tracing the Source of the Bio/Siliciclastic Beach Sands at Rosa Marina (Apulian Coast, SE Italy)
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Van Loon, A.J. (Tom), primary, Moretti, M., additional, Tropeano, M., additional, Acquafredda, P., additional, Baldacconi, R., additional, Festa, V., additional, Lisco, S., additional, Mastronuzzi, G., additional, Moretti, V., additional, and Scotti, R., additional
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- 2017
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31. Contributors
- Author
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Abbott, D., primary, Acquafredda, P., additional, Agangi, A., additional, Armstrong-Altrin, J.S., additional, Balakrishnan, S., additional, Baldacconi, R., additional, Basu, A., additional, Bennett, V.C., additional, Bose, P.K., additional, Breger, D., additional, Chakraborty, N., additional, Chakraborty, P.P., additional, Chan, M.A., additional, Chiarenzelli, J., additional, Chivas, A.R., additional, da Costa, G., additional, Das, K., additional, Dasgupta, P., additional, De, S., additional, deLorraine, W., additional, Dey, A., additional, Eriksson, P.G., additional, Fergusson, C.L., additional, Festa, V., additional, Friend, C.R.L., additional, Galinskaya, K., additional, Ghosh, S., additional, Gusiakov, V., additional, Han, Y., additional, Han, Z., additional, Henderson, R.A., additional, Hofmann, A., additional, Horie, K., additional, Ibanez-Mejia, M., additional, Jong, J., additional, Kessler, F.L., additional, Kratzmann, D., additional, Lisco, S., additional, Long, D.G.F., additional, Lupulescu, M., additional, Mandal, A., additional, Mastronuzzi, G., additional, Mazumder, R., additional, Mejiama, W., additional, Moretti, M., additional, Moretti, V., additional, Mukherjee, S., additional, Mukhopadhyay, J., additional, Nagarajan, R., additional, Nagendra, R., additional, Nutman, A.P., additional, Offler, R., additional, Pisarska-Jamroży, M., additional, Rambolamanana, G., additional, Rosiere, C.A., additional, Saha, S., additional, Sanyal, S., additional, Sarkar, S., additional, Sato, T., additional, Scotti, R., additional, Selleck, B., additional, Sengupta, P., additional, Shanmugam, G., additional, Tawfik, H.A., additional, Tropeano, M., additional, Tsutsumi, Y., additional, Van Loon, A.J. (Tom), additional, and Young, G.M., additional
- Published
- 2017
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32. From Photocatalysis to Photo-Electrocatalysis: An Innovative Water Remediation System for Sustainable Fish Farming
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Buoio, E., Cialini, C., Cafiso, A., Aidos, L., Mazzola, S., Rossi, R., Livolsi, S., Di Giancamillo, A., Moretti, V., Selli, E., Bestetti, M., Franz, S., Chiarello, G., Costa, A., and Bazzocchi, C.
- Subjects
photo-electrocatalysis ,Settore AGR/19 - Zootecnica Speciale ,Settore VET/06 - Parassitologia e Malattie Parassitarie degli Animali ,nitrogen-containing compounds ,rainbow trout ,water remediation ,welfare markers ,Settore AGR/09 - Meccanica Agraria ,Settore VET/01 - Anatomia degli Animali Domestici ,Settore VET/02 - Fisiologia Veterinaria ,Settore AGR/18 - Nutrizione e Alimentazione Animale ,Settore CHIM/02 - Chimica Fisica - Published
- 2022
33. Can a validated website help improve university students' e-health literacy?
- Author
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Conte, A., Brunelli, L., Moretti, V., Valdi, G., Guelfi, M. R., Masoni, M., Anelli, F., Parpinel, M., and Arnoldo, L.
- Subjects
HEALTH literacy ,INTERNET ,PUBLIC health ,COLLEGE students ,ONLINE education - Abstract
Copyright of Annali di Igiene, Medicina Preventiva e di Comunità is the property of Societa Editrice Universo s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
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34. Clinical correlates of paliperidone palmitate and aripiprazole monohydrate prescription for subjects with schizophreniaspectrum disorders: Findings from the STAR Network Depot Study
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Barbui C, Nosè M, Purgato M, Turrini G, Ostuzzi G, Mazzi MA, Papola D, Gastaldon C, Terlizzi S, Bertolini F, Piccoli A, Ruggeri M, De Fazio P, Magliocco F, Caroleo M, Raffaele G, D'Agostino A, Ostinelli EG, Chirico M, Cavallotti S, Lucii C, Bolognesi S, Debolini S, Pierantozzi E, Fargnoli F, Del Zanna M, Giannini A, Luccarelli L, De Capua A, Annese PM, Cerretini M, Tozzi F, Magnani N, Cardamone G, Bardicchia F, Facchi E, Soscia F, Zotos S, Biancosino B, Zonta F, Pompei F, Callegari C, Zizolfi D, Poloni N, Ielmini M, Caselli I, Giana E, Buzzi A, Diurni M, Milano A, Sani E, Calzolari R, Bortolaso P, Piccinelli M, Cazzamalli S, Alberini G, Piantanida S, Costantini C, Paronelli C, Di Caro A, Moretti V, Gozzi M, D'Ippolito C, Barbanti SV, Papalini A, Corbo M, Martinotti G, Campese O, Fiori F, Lorusso M, Di Capro L, Viceconte D, Mancini V, Suraniti F, Signorelli MSI, Rossi E, Lupoli P, Menchetti M, Terzi L, Boso M, Risaro P, De Paoli G, Catania C, Tarricone I, Caretto V, Storbini V, Emiliani R, Balzarro B, Carrà G, Bartoli F, Tabacchi T, Nava R, Bono A, Provenzi M, Brambilla G, Aspesi F, Trotta G, Tremolada M, Castagna G, Bava M, Verrengia E, Lucchi S, Oriani MG, Barchiesi M, Pacetti M, Aguglia A, Magni LR, Rossi G, Beneduce R, Tura GB, Laffranchini L, Mastromo D, Ferrato F, Restaino F, Monzani E, Porcellana M, Limosani I, Ghio L, Ferro M, Parise VF, Balletta G, Addeo L, De Vivo E, Di Benedetto R, Pinna F, Carpiniello B, Spano M, Giacomin M, Pecile D, Mattei C, Fabrici EP, Panarello S, Peresson G, Vitucci C, Bonavigo T, Perini G, Boschello F, Strizzolo S, Gardellin F, Di Giannantonio M, Moretti D, Fizzotti C, Cossetta E, Di Gregorio L, Sozzi F, Boncompagni G, La Barbera D, Colli G, Laurenzi S, Calandra C, Luca M, Crocamo C, STAR Network Depot Investigators, Bartoli F., Ostuzzi G., Crocamo C., Corbo M., D'Agostino A., Martinotti G., Ostinelli E.G., Tabacchi T., Barbui C., Carr G., Nose M., Purgato M., Turrini G., Mazzi M.A., Papola D., Gastaldon C., Terlizzi S., Bertolini F., Piccoli A., Ruggeri M., De Fazio P., Magliocco F., Caroleo M., Raffaele G., Chirico M., Cavallotti S., Lucii C., Bolognesi S., Debolini S., Pierantozzi E., Fargnoli F., Del Zanna M., Giannini A., Luccarelli L., De Capua A., Annese P.M., Cerretini M., Tozzi F., Magnani N., Cardamone G., Bardicchia F., Facchi E., Soscia F., Zotos S., Biancosino B., Zonta F., Pompei F., Callegari C., Zizolfi D., Poloni N., Ielmini M., Caselli I., Giana E., Buzzi A., Diurni M., Milano A., Sani E., Calzolari R., Bortolaso P., Piccinelli M., Cazzamalli S., Alberini G., Piantanida S., Costantini C., Paronelli C., Di Caro A., Moretti V., Gozzi M., D'Ippolito C., Barbanti S.V., Papalini A., Campese O., Fiori F., Lorusso M., Di Capro L., Viceconte D., Mancini V., Suraniti F., Signorelli M.S., Rossi E., Lupoli P., Menchetti M., Terzi L., Boso M., Risaro P., De Paoli G., Catania C., Tarricone I., Caretto V., Storbini V., Emiliani R., Balzarro B., Carra G., Nava R., Bono A., Provenzi M., Brambilla G., Aspesi F., Trotta G., Tremolada M., Castagna G., Bava M., Verrengia E., Lucchi S., Oriani M.G., Barchiesi M., Pacetti M., Aguglia A., Magni L.R., Rossi G., Beneduce R., Tura G.B., Laffranchini L., Mastromo D., Ferrato F., Restaino F., Monzani E., Porcellana M., Limosani I., Ghio L., Ferro M., Parise V.F., Balletta G., Addeo L., De Vivo E., Di Benedetto R., Pinna F., Carpiniello B., Spano M., Giacomin M., Pecile D., Mattei C., Fabrici E.P., Panarello S., Peresson G., Vitucci C., Bonavigo T., Perini G., Boschello F., Strizzolo S., Gardellin F., Di Giannantonio M., Moretti D., Fizzotti C., Cossetta E., Di Gregorio L., Sozzi F., Boncompagni G., La Barbera D., Colli G., Laurenzi S., Calandra C., Luca M., Barbui C, Nosè M, Purgato M, Turrini G, Ostuzzi G, Mazzi MA, Papola D, Gastaldon C, Terlizzi S, Bertolini F, Piccoli A, Ruggeri M, De Fazio P, Magliocco F, Caroleo M, Raffaele G, D'Agostino A, Ostinelli EG, Chirico M, Cavallotti S, Lucii C, Bolognesi S, Debolini S, Pierantozzi E, Fargnoli F, Del Zanna M, Giannini A, Luccarelli L, De Capua A, Annese PM, Cerretini M, Tozzi F, Magnani N, Cardamone G, Bardicchia F, Facchi E, Soscia F, Zotos S, Biancosino B, Zonta F, Pompei F, Callegari C, Zizolfi D, Poloni N, Ielmini M, Caselli I, Giana E, Buzzi A, Diurni M, Milano A, Sani E, Calzolari R, Bortolaso P, Piccinelli M, Cazzamalli S, Alberini G, Piantanida S, Costantini C, Paronelli C, Di Caro A, Moretti V, Gozzi M, D'Ippolito C, Barbanti SV, Papalini A, Corbo M, Martinotti G, Campese O, Fiori F, Lorusso M, Di Capro L, Viceconte D, Mancini V, Suraniti F, Signorelli MSI, Rossi E, Lupoli P, Menchetti M, Terzi L, Boso M, Risaro P, De Paoli G, Catania C, Tarricone I, Caretto V, Storbini V, Emiliani R, Balzarro B, Carrà G, Bartoli F, Tabacchi T, Nava R, Bono A, Provenzi M, Brambilla G, Aspesi F, Trotta G, Tremolada M, Castagna G, Bava M, Verrengia E, Lucchi S, Oriani MG, Barchiesi M, Pacetti M, Aguglia A, Magni LR, Rossi G, Beneduce R, Tura GB, Laffranchini L, Mastromo D, Ferrato F, Restaino F, Monzani E, Porcellana M, Limosani I, Ghio L, Ferro M, Parise VF, Balletta G, Addeo L, De Vivo E, Di Benedetto R, Pinna F, Carpiniello B, Spano M, Giacomin M, Pecile D, Mattei C, Fabrici EP, Panarello S, Peresson G, Vitucci C, Bonavigo T, Perini G, Boschello F, Strizzolo S, Gardellin F, Di Giannantonio M, Moretti D, Fizzotti C, Cossetta E, Di Gregorio L, Sozzi F, Boncompagni G, La Barbera D, Colli G, Laurenzi S, Calandra C, Luca M, Crocamo C, STAR Network Depot Investigators, Bartoli, F, Ostuzzi, G, Crocamo, C, Corbo, M, D'Agostino, A, Martinotti, G, Ostinelli, E, Tabacchi, T, Barbui, C, and Carra, G
- Subjects
Aripiprazole monohydrate ,Long-acting injectable antipsychotics ,Paliperidone palmitate ,Schizophrenia ,Adult ,Antipsychotic Agents ,Aripiprazole ,Female ,Health Knowledge, Attitudes, Practice ,Humans ,Male ,Medication Adherence ,Paliperidone Palmitate ,Practice Patterns, Physicians' ,Schizophrenic Psychology ,Young Adult ,Long-acting injectable antipsychotic ,medicine.medical_specialty ,medicine.medical_treatment ,Aripiprazole monohydrate, Long-acting injectable antipsychotics, Paliperidone palmitate, Schizophrenia ,Practice Patterns ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Brief Psychiatric Rating Scale ,medicine ,Pharmacology (medical) ,Antipsychotic ,Settore MED/25 - Psichiatria ,Practice ,Physicians' ,business.industry ,Health Knowledge ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Attitudes ,Propensity score matching ,Observational study ,business ,030217 neurology & neurosurgery ,medicine.drug ,Psychopathology - Abstract
This study, based on the 'Servizi Territoriali Associati per la Ricerca' (STAR) Network Depot Study nationwide baseline data, explored whether individual symptoms severity and clusters might influence the prescription of paliperidone palmitate 1-month (PP1M) vs. aripiprazole monohydrate. The Brief Psychiatric Rating Scale (BPRS) was used to assess psychopathology and relevant symptoms clusters. Drug Attitude Inventory, 10 items, was used to test attitude towards medications. Adherence to treatments was rated according to the Kemp seven-point scale. We assessed for eligibility 451 individuals and, among them, we included 195 subjects (n = 117 who started PPM1 and n = 78 aripiprazole monohydrate). Individuals were comparable in terms of age, gender, treatment years, recent hospitalizations, previous long-acting injectable antipsychotic treatments, additional oral treatments, attitude toward drugs, medication adherence, and alcohol/substance-related comorbidities. Subjects starting PP1M presented higher BPRS overall (P = 0.009), positive (P = 0.015), and negative (P = 0.010) symptom scores compared to subjects starting aripiprazole monohydrate. Results were confirmed by appropriate regression models and propensity score matching analysis. No differences were found comparing the other BPRS subscale scores: affect, resistance, and activation. Clinicians may be more prone to prescribe PPM1, rather than aripiprazole monohydrate, to subjects showing higher overall symptom severity, including positive and negative symptoms. No additional clinical factors influenced prescribing attitudes in our sample.
- Published
- 2020
35. Role of rare and common variants in the diagnosis of adults with cryptogenic liver and lipid disorders
- Author
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Ronzoni, L., Pelusi, S., Moretti, V., Malvestiti, F., Torghabehei, H.E., Rondena, J., Periti, G., Bianco, C., De Filippo, M., Prati, D., and Valenti, L.
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- 2024
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- View/download PDF
36. Energy and macronutrients intake in an Italian infants cohort at 24 months of age
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Valdi, G, primary, Moretti, V, additional, Concina, F, additional, Pani, P, additional, Carletti, C, additional, Ronfani, L, additional, and Parpinel, M, additional
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- 2021
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37. The impact of the second victim phenomenon in an Italian Academic Hospital: a cross-sectional study
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Moretti, V, primary, Scarpis, E, additional, Ruscio, E, additional, Bianchet, B, additional, Doimo, A, additional, Farneti, F, additional, Castriotta, L, additional, Quattrin, R, additional, and Cocconi, R, additional
- Published
- 2021
- Full Text
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38. Safety culture in COVID-19 wards during 2020 SARS-COV-2 pandemic
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Bianchet, B, primary, Doimo, A, additional, Moretti, V, additional, Bellomo, F, additional, Degan, S, additional, Farneti, F, additional, and Cocconi, R, additional
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- 2021
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- View/download PDF
39. e-Health Literacy among medical students
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Moretti, V, primary, Valdi, G, additional, Brunelli, L, additional, Arnoldo, L, additional, Conte, A, additional, Masoni, M, additional, Guelfi, MR, additional, and Anelli, F, additional
- Published
- 2021
- Full Text
- View/download PDF
40. 2020 healthcare workers flu vaccination during covid-19: the experience of Udine University Hospital
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Chirico, L, primary, Moretti, V, additional, Valdi, G, additional, Varadi, G, additional, Da Ros, R, additional, Pozzi, D, additional, Brunelli, L, additional, and Cocconi, R, additional
- Published
- 2021
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41. Impact of Covid-19 on incident reporting
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Doimo, A, primary, Bianchet, B, additional, Moretti, V, additional, Mellace, F, additional, Favero, B, additional, Longobardi, G, additional, Bellomo, F, additional, Degan, S, additional, Farneti, F, additional, and Cocconi, R, additional
- Published
- 2021
- Full Text
- View/download PDF
42. CELLOW-FeeP Project - Circular Economic: Live Larvae recycling Organic Waste for rural Poultry
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Gasco, L., Schiavone, A., Cerolini, S., Bellagamba, F., Bongiorno, V., Capucchio, M. T., Dinuccio, E., Ferrocino, I., Moretti, V., Nucera, D. M., Bellezza Oddon, S., Renna, M., Biasato, I., Tedeschi, G., and Zaniboni, L.
- Published
- 2021
43. Quality of Primary Food Products as Affected by Climate Change
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Savoini, G. and Moretti, V. M.
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- 2006
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44. What do Italians at high risk of stroke know about ischaemic stroke? A survey among a group of subjects undergoing neuro-sonographic examination
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De Dominicis, L., Cardinali, P., Pucci, E., Marchegiani, G., Caporalini, R., Moretti, V., Sanguigni, S., Carle, F., Gesuita, R., and Giuliani, G.
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- 2006
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45. Second victim experience: cross-sectional survey at the Department of Maternal-Child Health in Udine
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Scarpis, E, primary, Ruscio, E, additional, Bianchet, B, additional, Doimo, A, additional, Moretti, V, additional, Cocconi, R, additional, Farneti, F, additional, Castriotta, L, additional, and Quattrin, R, additional
- Published
- 2020
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46. Flu vaccination coverage among healthcare workers: a comparison between 2018 and 2019 campaigns
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Varadi, G, primary, Vacchi, O G B, additional, Moretti, V, additional, Pozzi, D, additional, Chirico, L, additional, Del Pin, M, additional, Brunelli, L, additional, Cocconi, R, additional, and Brusaferro, S, additional
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- 2020
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47. Second Victim Experience and Support Tool: cultural adaptation and psychometric evaluation in Italy
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Scarpis, E, primary, Ruscio, E, additional, Bianchet, B, additional, Doimo, A, additional, Moretti, V, additional, Cocconi, R, additional, Farneti, F, additional, Castriotta, L, additional, and Quattrin, R, additional
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- 2020
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48. 3PC-029 Paediatric drug resistant epilepsy: nitrazepam 1 mg/mL solutions to avoid clinical therapeutic error
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Berardi, MA, primary, Ortenzi, GB, additional, Moretti, V, additional, Adresciani, E, additional, Garzone, AMF, additional, Cappanera, S, additional, Polidori, C, additional, and Pompilio, A, additional
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- 2020
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49. After entry to a residence: therapies and quality of life for people with ID and mental disorders
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Moretti, V., Villanti, F., and Ruggerini, C.
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- 2010
50. Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy
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Ostuzzi, G., Mazzi, M. A., Terlizzi, S., Bertolini, F., Aguglia, A., Bartoli, F., Bortolaso, P., Callegari, C., Caroleo, M., Carrà, G., Corbo, M., D'Agostino, A., Gastaldon, C., Lucii, C., Magliocco, F., Martinotti, G., Nosé, M., Ostinelli, E. G., Papola, D., Piccinelli, M. P., Piccoli, A., Purgato, M., Tabacchi, T., Turrini, G., Ruggeri, M., Barbui, C., De Fazio, P., Raffaele, G., Chirico, M., Cavallotti, S., Bolognesi, S., Debolini, S., Pierantozzi, E., Fargnoli, F., Del Zanna, M., Giannini, A., Luccarelli, L., De Capua, A., Annese, P. M., Cerretini, M., Tozzi, F. E., Magnani, N., Cardamone, G., Bardicchia, F., Facchi, E., Soscia, F., Zotos, S., Biancosino, B., Zonta, F., Pompei, F., Zizolfi, D., Poloni, N., Ielmini, M., Caselli, I., Giana, E., Buzzi, A., Diurni, M., Milano, A., Sani, E., Calzolari, Roberta, Cazzamalli, S., Alberini, Gabrio, Piantanida, Silvia, Costantini, C., Paronelli, Chiara, Di Caro, A., Moretti, V., Gozzi, M., D'Ippolito, C., Barbanti, S. V., Alessandro, P., Campese, O., Fiori, F., Lorusso, M., Di Capro, L., Viceconte, D., Mancini, V., Suraniti, F., Signorelli, M. S., Rossi, E., Lupoli, P., Menchetti, M., Terzi, L., Boso, M., Risaro, P., De Paoli, G., Catania, C., Tarricone, I., Caretto, V., Storbini, V., Emiliani, R., Balzarro, B., Nava, R., Bono, A., Provenzi, M., Brambilla, G., Aspesi, F., Tremolada, M., Castagna, G., Bava, M., Verrengia, E., Lucchi, S., Oriani, M. G., Barchiesi, M., Pacetti, M., Magni, L. R., Rossi, G., Beneduce, R., Tura, G. B., Laffranchini, L., Mastromo, D., Ferrato, F., Restaino, F., Monzani, E., Porcellana, M., Limosani, I., Ghio, L., Ferro, M., Parise, V. F., Balletta, G., Addeo, L., De Vivo, E., Benedetto, R. D., Pinna, F., Carpiniello, B., Spano, M., Giacomin, M., Pecile, D., Mattei, C., Fabrici, E. P., Panarello, S., Peresson, G., Vitucci, C., Bonavigo, T., Perini, G., Boschello, F., Strizzolo, S., Gardellin, F., Di Giannantonio, M., Moretti, D., Fizzotti, C., Cossetta, E., Gregorio, L. D., Sozzi, F., Boncompagni, G., Barbera, D. L., Colli, G., Laurenzi, S., Calandra, C., Luca, M., Ostuzzi, Giovanni, Mazzi, Maria Angela, Terlizzi, Samira, Bertolini, Federico, Aguglia, Andrea, Bartoli, Francesco, Bortolaso, Paola, Callegari, Camilla, Caroleo, Mariarita, Carrà, Giuseppe, Corbo, Mariangela, D'Agostino, Armando, Gastaldon, Chiara, Lucii, Claudio, Magliocco, Fabio, Martinotti, Giovanni, Nosé, Michela, Ostinelli, Edoardo Giuseppe, Papola, Davide, Piccinelli, Marco Piero, Piccoli, Alberto, Purgato, Marianna, Tabacchi, Tommaso, Turrini, Giulia, Ruggeri, Mirella, Barbui, Corrado, De Fazio, Pasquale, Raffaele, Gaetano, Chirico, Margherita, Cavallotti, Simone, Bolognesi, Simone, Debolini, Sara, Pierantozzi, Elisa, Fargnoli, Francesco, Del Zanna, Maria, Giannini, Alessandra, Luccarelli, Livia, De Capua, Alberto, Annese, Pasqua Maria, Cerretini, Massimiliano, Tozzi, Fior-Ella, Magnani, Nadia, Cardamone, Giuseppe, Bardicchia, Francesco, Facchi, Edvige, Soscia, Federica, Zotos, Spyridon, Biancosino, Bruno, Zonta, Filippo, Pompei, Francesco, Zizolfi, Daniele, Poloni, Nicola, Ielmini, Marta, Caselli, Ivano, Giana, Edoardo, Buzzi, Aldo, Diurni, Marcello, Milano, Anna, Sani, Emanuele, Calzolari, Roberta, Piccinelli, Marco, Cazzamalli, Sara, Alberini, Gabrio, Piantanida, Silvia, Costantini, Chiara, Paronelli, Chiara, Di Caro, Angela, Moretti, Valentina, Gozzi, Mauro, D'Ippolito, Chiara, Barbanti, Silva Veronica, Alessandro, Papalini, Campese, Ornella, Fiori, Federica, Lorusso, Marco, Di Capro, Lucia, Viceconte, Daniela, Mancini, Valerio, Suraniti, Francesco, Signorelli, Maria Salvina, Rossi, Eugenio, Lupoli, Pasqualino, Menchetti, Marco, Terzi, Laura, Boso, Marianna, Risaro, Paolo, De Paoli, Giuseppe, Catania, Cristina, Tarricone, Ilaria, Caretto, Valentina, Storbini, Viviana, Emiliani, Roberta, Balzarro, Beatrice, Nava, Roberto, Bono, Adele, Provenzi, Milena, Brambilla, Giulia, Aspesi, Flora, Tremolada, Martina, Castagna, Gloria, Bava, Mattia, Verrengia, Enrica, Lucchi, Sara, Oriani, Maria Ginevra, Barchiesi, Michela, Pacetti, Monica, Magni, Laura Rosa, Rossi, Giuseppe, Beneduce, Rossella, Tura, Giovanni Battista, Laffranchini, Laura, Mastromo, Daniele, Ferrato, Farida, Restaino, Francesco, Monzani, Emiliano, Porcellana, Matteo, Limosani, Ivan, Ghio, Lucio, Ferro, Maurizio, Parise, Vincenzo Fricchione, Balletta, Giovanni, Addeo, Lelio, De Vivo, Elisa, Benedetto, Rossella Di, Pinna, Federica, Carpiniello, Bernardo, Spano, Mariangela, Giacomin, Marzio, Pecile, Damiano, Mattei, Chiara, Fabrici, Elisabetta Pascolo, Panarello, Sofia, Peresson, Giulia, Vitucci, Claudio, Bonavigo, Tommaso, Perini, Giovanni, Boschello, Filippo, Strizzolo, Stefania, Gardellin, Francesco, Di Giannantonio, Massimo, Moretti, Daniele, Fizzotti, Carlo, Cossetta, Edoardo, Gregorio, Luana Di, Sozzi, Francesca, Boncompagni, Giancarlo, Barbera, Daniele La, Colli, Giuseppe, Laurenzi, Sabrina, Calandra, Carmela, Luca, Maria, Ostuzzi, G, Mazzi, M, Terlizzi, S, Bertolini, F, Aguglia, A, Bartoli, F, Bortolaso, P, Callegari, C, Caroleo, M, Carrà, G, Corbo, M, D'Agostino, A, Gastaldon, C, Lucii, C, Magliocco, F, Martinotti, G, Nosé, M, Ostinelli, E, Papola, D, Piccinelli, M, Piccoli, A, Purgato, M, Tabacchi, T, Turrini, G, Ruggeri, M, Barbui, C, De Fazio, P, Raffaele, G, Chirico, M, Cavallotti, S, Bolognesi, S, Debolini, S, Pierantozzi, E, Fargnoli, F, Del Zanna, M, Giannini, A, Luccarelli, L, De Capua, A, Annese, P, Cerretini, M, Tozzi, F, Magnani, N, Cardamone, G, Bardicchia, F, Facchi, E, Soscia, F, Zotos, S, Biancosino, B, Zonta, F, Pompei, F, Zizolfi, D, Poloni, N, Ielmini, M, Caselli, I, Giana, E, Buzzi, A, Diurni, M, Milano, A, Sani, E, Calzolari, R, Cazzamalli, S, Alberini, G, Piantanida, S, Costantini, C, Paronelli, C, Di Caro, A, Moretti, V, Gozzi, M, D'Ippolito, C, Barbanti, S, Alessandro, P, Campese, O, Fiori, F, Lorusso, M, Di Capro, L, Viceconte, D, Mancini, V, Suraniti, F, Signorelli, M, Rossi, E, Lupoli, P, Menchetti, M, Terzi, L, Boso, M, Risaro, P, De Paoli, G, Catania, C, Tarricone, I, Caretto, V, Storbini, V, Emiliani, R, Balzarro, B, Nava, R, Bono, A, Provenzi, M, Brambilla, G, Aspesi, F, Tremolada, M, Castagna, G, Bava, M, Verrengia, E, Lucchi, S, Oriani, M, Barchiesi, M, Pacetti, M, Magni, L, Rossi, G, Beneduce, R, Tura, G, Laffranchini, L, Mastromo, D, Ferrato, F, Restaino, F, Monzani, E, Porcellana, M, Limosani, I, Ghio, L, Ferro, M, Parise, V, Balletta, G, Addeo, L, De Vivo, E, Benedetto, R, Pinna, F, Carpiniello, B, Spano, M, Giacomin, M, Pecile, D, Mattei, C, Fabrici, E, Panarello, S, Peresson, G, Vitucci, C, Bonavigo, T, Perini, G, Boschello, F, Strizzolo, S, Gardellin, F, Di Giannantonio, M, Moretti, D, Fizzotti, C, Cossetta, E, Gregorio, L, Sozzi, F, Boncompagni, G, Barbera, D, Colli, G, Laurenzi, S, Calandra, C, and Luca, M
- Subjects
Genetics and Molecular Biology (all) ,Male ,Pediatrics ,European People ,Bipolar Disorder ,Cross-sectional study ,Economics ,Epidemiology ,medicine.medical_treatment ,assessment ,viruses ,lcsh:Medicine ,Social Sciences ,Longitudinal Studie ,Biochemistry ,Prescription ,Geographical locations ,0302 clinical medicine ,Mathematical and Statistical Techniques ,Biochemistry, Genetics and Molecular Biology (all) ,Agricultural and Biological Sciences (all) ,immune system diseases ,Medicine and Health Sciences ,long-acting intramuscular (LAI) antipsychotics ,clinical practice ,second-generation antipsychotic (SGA) LAIs ,Antipsychotics ,Ethnicities ,Longitudinal Studies ,lcsh:Science ,Multidisciplinary ,virus diseases ,Drugs ,Middle Aged ,Italian People ,Europe ,Prescriptions ,Italy ,Physical Sciences ,Aripiprazole ,Female ,Bivariate Analysis ,Statistics (Mathematics) ,medicine.drug ,Human ,Research Article ,Antipsychotic Agents ,Employment ,Adult ,medicine.medical_specialty ,Adolescent ,Research and Analysis Methods ,03 medical and health sciences ,Mental Health and Psychiatry ,medicine ,Humans ,Paliperidone ,Bipolar disorder ,European Union ,Statistical Methods ,Antipsychotic ,Cross-Sectional Studie ,Pharmacology ,Risperidone ,business.industry ,Mood Disorders ,lcsh:R ,medicine.disease ,030227 psychiatry ,Antipsychotic Agent ,Cross-Sectional Studies ,Labor Economics ,Multivariate Analysis ,Schizophrenia ,Observational study ,lcsh:Q ,Population Groupings ,People and places ,business ,030217 neurology & neurosurgery ,Mathematics - Abstract
Background For many years, long-acting intramuscular (LAI) antipsychotics have been prescribed predominantly to chronic and severe patients, as a last resort when other treatments failed. Recently, a broader and earlier use of LAIs, particularly second-generation LAIs, has been emphasized. To date, few studies attempted to frame how this change in prescribing took place in real-world practice. Therefore, this study aimed to describe the clinical features of patients prescribed with LAIs, and to explore possible prescribing differences between first- and second-generations LAIs under ordinary clinical practice in Italy. Methods The STAR Network "Depot" Study is an observational, longitudinal, multicenter study involving 35 centers in Italy. In the cross-sectional phase, patients prescribed with LAIs were consecutively recruited and assessed over a period of 12 months. Descriptive statistics and multivariable logistic regression analyses were employed. Results Of the 451 recruited patients, 61% were males. The level of social and working functioning was heterogeneous, as was the severity of disease. Seventy-two per cent of the patients had a diagnosis of the schizophrenia spectrum. Seventy per cent were prescribed with second-generation antipsychotic (SGA) LAIs (mostly paliperidone, aripiprazole and risperidone). Compared to first-generation antipsychotic (FGA) LAIs, patients prescribed with SGA LAIs were more often younger; employed; with a diagnosis of the schizophrenia spectrum or bipolar disorder; with higher levels of affective symptoms; with fewer LAI prescriptions in the past. Discussion LAIs' prescribing practices appear to be more flexible as compared to the past, although this change is mostly restricted to SGA LAIs.
- Published
- 2018
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