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Brazilian jalap root, Operculina hamiltonii (G. Don) D.F. Austin & Staple, Convolvulaceae, belongs to the morning glory family and is used as a purgative or laxative medicinal plant. After hydrolysis and peracetylation of the EtOH-soluble extract, the known operculinic acids A and B and turpethic acid C, in addition to three undescribed glycosidic acids, operculinic acids L-N with a tetrasaccharide or pentasaccharide moieties with unusual 12-hydroxy fatty acid aglycones of different chain lengths (C17 and C18), were isolated from a commercial sample of pulverized roots by preparative recycling HPLC. Analysis of sixteen samples, including crude drugs and commercial phytopharmaceuticals based on jalap root, led to the generation of distinctive chromatographic profiles for each sample. The major isolated glycosidic acids were used as diagnostic peaks for HPLC-ESIMS fingerprinting by selected ion monitoring mode using target ions at [M + Na]+.

El presente trabajo busca identificar y definir acciones estratégicas que ayuden a visibilizar y convertir el agua en una herramienta indispensable para construir una paz duradera en la región del Urabá Antioqueño. Se parte de la premisa de que no se puede haber paz en ningún territorio si la población no tiene acceso a agua potable, si los acuíferos están contaminados o su aprovechamiento se encuentra limitado por el control territorial de agentes distintos a las instituciones del estado y las comunidades que los habitan. Y esta es la razón por la cual, tras la firma de los Acuerdos de Paz de La Habana en 2016, se pone en evidencia el agua como un elemento estructurante y articulador de los proyectos identificados por las comunidades para garantizar la paz en el territorio. Pero ¿Qué significa vivir en paz? Este trabajo establece una segunda premisa: la construcción de la paz no se puede separar del ordenamiento y la gestión del territorio. Vivir en paz significa garantizar condiciones de vida que provean recursos sanitarios y hospitalarios, oportunidades económicas, seguridad alimentaria y un ambiente físico sin amenazas. Con este enfoque, se ponen en consideración los diferentes instrumentos, planes y proyectos para los cuales el agua es un elemento esencial para el desarrollo de la región, y se hace énfasis en las iniciativas priorizadas en los Planes de Desarrollo con Enfoque Territorial (PDET) tomando como caso de estudio el núcleo veredal El Tres, del Distrito Portuario de Turbo. Este documento se compone de cuatro capítulos que construyen una ruta del conocimiento en torno al agua. El primer capítulo analiza el papel del agua como herramienta para la implementación de los Acuerdos de Paz, en el marco de la creación de los PDET. El segundo capítulo ahonda en la caracterización geográfica e histórica del área de estudio y detalla los diferentes instrumentos de gestión y planificación en aras de elaborar una hoja de ruta metodológica para abordar la multiplicidad de acciones e intenciones que confluyen en un mismo territorio. El tercer capítulo es una síntesis de los diferentes componentes que conforman la red de estrategias para la gestión del agua, desde lo ambiental, lo social y lo institucional. Finalmente, en el capítulo cuarto, se examinan seis proyectos habilitantes de pequeña y gran escala enmarcados en seis líneas estratégicas. Dicho recorrido nos lleva a un nuevo comienzo donde el agua se convierte en el elemento habilitante de las diferentes iniciativas y proyectos priorizados por las comunidades en el marco de los Acuerdos de Paz y en elemento articulador de los diferentes instrumentos que operan en el territorio. El trabajo busca, entre otras cosas, mostrar que un elemento tan esencial como el agua no es únicamente un recurso, sino la clave para el desarrollo de aquellas comunidades que buscan la construcción de una paz estable y duradera., This thesis seeks to identify and define strategic actions that help to turn water a important way to resolve conflicts and convert it into an indispensable tool for building peace in the region of Urabá Antioqueño. It is based on the premise that there can be no peace in any territory if the population does not have access to drinking water, if the aquifers are contaminated or if their use is limited by the territorial control of agents other than state institutions and the communities that inhabit them. And this is the reason why, after the signing of the Havana Peace Accords in 2016, water is highlighted as a structuring and articulating element of the projects identified by the communities to guarantee peace in the territory. But, what does it mean to live in peace? This work establishes a second premise: peace construction cannot be separated from territorial planning and management. Living in peace means guaranteeing living conditions that provide health and hospital resources, economic opportunities, food security and a physical environment free of threats. With this approach, the different instruments, plans and projects for which water is an essential element for the development of the region are considered, and emphasis is placed on the initiatives prioritized in Planes de Desarrollo con Enfoque Territorial (PDET), taking as a case study El Tres, Turbo - Antioquia. This document is composed of four chapters that build a knowledge route around water. The first chapter analyzes the role of water as a tool for the implementation of the Peace Agreements, in the framework of the creation of the PDETs. The second chapter delves into the geographical and historical characterization of the study area and details the different management and planning instruments in order to develop a methodological roadmap to address the multiplicity of actions and intentions that converge in the same territory. The third chapter is a synthesis of the different components that make up the network of strategies for water management, from the environmental, social and institutional perspectives. Finally, the fourth chapter examines six enabling projects of small and large scale framed in six strategic lines. This journey takes us to a new beginning where water becomes the enabling element of the different initiatives and projects prioritized by the communities within the framework of the Peace Agreements and the articulating element of the different instruments operating in the territory. The work seeks, among other things, to show that such an essential element as water is not only a resource, but the key to the development of those communities seeking to build a stable and lasting peace.

Identificar la solución de la metodología de tratamiento superficial en pavimento flexible que garantice serviciabilidad y maximice el período de diseño de la carrera 8 (octava) del municipio de Agua de Dios, (Cundinamarca). En el presente documento se realizará como objetivo principal el análisis, diagnóstico de metodologías de tratamientos superficiales en pavimentos flexibles en la carrera 8 (octava) del Municipio de Agua de Dios (Cundinamarca). Tomando como punto de partida la importancia de esta vía para el municipio y su notable deterioramiento, el cual es evidenciado por medio de registros fotográficos que muestran el estado superficial de la vía. Una de las patologías existentes en la vía son los baches, los cuales generan una gran afectación en la movilidad del municipio generando aglomeraciones vehiculares y un alto índice de accidentalidad según los habitantes del municipio, ya que por medio de herramientas investigativas se realizó una encuesta a los habitantes arrojando inconformidad con el estado actual de la vía. Por medio de un aforo vehicular se determinó el transito promedio diario y los tipos de vehículos que transitan por la carrera octava del municipio de Agua de Dios. Observando que transitan todo tipo de vehículos los cuales producen un daño considerable en la vía The main objective of this document is the analysis, diagnosis of surface treatment methodologies in flexible pavements in Carrera 8 (eighth) of the Municipality of Agua de Dios (Cundinamarca). Taking as a starting point the importance of this road for the municipality and its notable deterioration, which is evidenced by means of photographic records that show the surface condition of the road. One of the existing pathologies on the road are potholes, which greatly affect the mobility of the municipality, generating vehicular agglomeration and a high accident rate according to the inhabitants of the municipality, since a survey was carried out using investigative tools to the inhabitant’s throwing dissatisfaction with the current state of the road. By means of a vehicle capacity, the average daily traffic and the types of vehicles that travel through the eighth race of the municipality of Agua de Dios were determined. Observing that all types of vehicles transit which produce considerable damage on the road.

Cobalt toxicity in patients with hip arthroplasty is a rare complication, but it should be considered in those patients who, after a ceramic fracture, were implanted with a metal-on-polyethylene prosthesis. The complete removal of ceramic particles during revision surgery can be complicated. If the bearing surface is replaced with a metal-on-polyethylene prosthesis, these residual ceramic particles may wear down the chrome-cobalt head, producing localised metallosis. This can trigger blood metal ion levels to rise, causing systemic toxicity. Visual and auditory alterations, cognitive deterioration, hypothyroidism, neuropathy, cardiomyopathy, anorexia, fatigue, diabetes, polycythemia, and respiratory and cutaneous symptoms are some of the clinical manifestations of prosthetic cobaltism.A young patient presented with multiorgan failure secondary to cobalt toxicity after a ceramic fracture and revision with a metal-on-polyethylene prosthesis; his serum cobalt and chromium levels were 652 μg/L and 270 μg/L, respectively. The patient needed a heart transplant after presenting with cobalt-induced cardiogenic shock.In a patient with a ceramic fracture who is subjected to revision surgery with a metal-on-polyethylene bearing, it is necessary to rule out the possibility of cobalt intoxication. Serum cobalt levels20 μg/L are inadmissible; in these cases, surgical treatment should be considered in the short term. A wide synovectomy and replacement of components should be performed with hard friction options, preferably with a ceramic-on-ceramic prosthesis.

Ilustraciones, tablas Se ha realizado una aproximación a la plataforma Pinturillo2, para ello se realiza una triangulación metodológica, por la cual se realizó un acercamiento etnográfico a los chats como escenario social de dicha plataforma con tal de describirlos, asimismo se lleva a cabo la captación de correlatos electrofisiológicos por medio de EEG en participantes dentro del rango de 18 a 23 años, enfocándose en el ritmo gamma, en una tarea online en la plataforma Pinturillo2 y una adaptación offline o física de esta misma, para su posterior análisis por medio de ANOVA. An approach to the Pinturillo2 platform has been carried out, for this a methodological triangulation is carried out, by which an ethnographic approach was made to the chats as a social scene of said platform in order to describe them, also the capture of electrophysiological correlates is carried out by means of EEG in participants within the range of 18 to 23 years, focusing on the gamma rhythm, on an online task on the Pinturillo2 platform and an offline or physical adaptation of it, for subsequent analysis by means of ANOVA. Pregrado Antropologo(a)

The regional elections in Catalonia held on 21 December 2017 received wide media coverage, far beyond Spanish media, due to separatist tension in that territory and was one of the main topics in most of the world’s media. Within this process social networks, especially Twitter, obtained crucial relevance given the interest aroused by the political leaders’ publications, since in those elections the debate transcended the usual ideological divisions of right and left and became a struggle between constitutionalists and separatists. This paper analyses the presence and influence of the main candidates of the Catalan political parties on Twitter. To achieve this, a mainly quantitative, mixed methodology based on big data was carried out where all the tweets issued by the candidates during the electoral campaign were analysed.

Background: The influence of vocation on success can be studied through various surveys, but a model is needed that will validate the results of such surveys with a high probability of accurately representing the reality under study. Bayesian networks meet this requirement Purpose: Students who enroll on an engineering degree may have to choose engineering disciplines that differ from their initial choice. In some cases, these differences can undermine their vocational commitment and leave them with the feeling that their final choice was mistaken. This study is intended to gauge engineering student perceptions of success in terms of vocation and to remedy weaknesses that may discernible in their attitudes. Method: Bayesian networks, by choosing a variable, proper graphs, probabilistic calculation and survey validations with the ROC curve (Receiver Operating Characteristic) can identify variable-dependent survey results and filter them accordingly. Results: Issues relating to professional expectations and learning have more influence on students whether they are or are not in the specific field of engineering that reflected their vocation. Success rates increase considerably when students perceive variables such as "find useful work", "find a job easily" or "enjoy learning" in a positive light. Conclusions: What helps students to feel that they are not wrong is to think that they will find employment and that their jobs will make them feel useful. It is therefore essential to talk about professional life from the very first year through to graduation and students should do so believing fully in their choice of degree.

The aim was to identify effective surgical treatments for patients with rheumatoid arthritis in the foot and/or ankle. A systematic review of the literature was conducted via a data search of the PubMed, Scopus, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and PROSPERO databases, from their inception until June 2019. Only non-randomized controlled trials and cohort studies were included in this review. Two of the present authors independently assessed the quality of each study and extracted the relevant data. A quality assessment of all articles was performed using the methodological index for non-randomized studies criteria. In addition, the Newcastle Ottawa scale was used for cohort studies. Thirteen studies met the inclusion criteria (five cohort studies and eight NRCTs). The total population considered was 923 patients (570 patients had RA), with a mean age of 58.8 years. Regarding the risk of bias, both the NRCTs and the cohort studies had a moderate level of quality. Despite the relatively low quality of these studies, surgical treatment for the foot and/or ankle is shown to reduce pain and improve functionality in patients with RA, in the short term (6–12 months).

Este trabajo se realiza con el fin de crear un marco teórico a través del cual se puedan establecer los factores que se consideran claves en la transferencia de conocimiento entre las empresas, quienes debido a las cambios que se presentan dada la globalización, se ven obligadas constantemente a adquirir nuevos conocimientos con el fin de continuar innovando en el mercado y satisfaciendo las necesidades de los consumidores.

International audience; The main purpose of the present study was to analyse the internal structure and to test the measurement invariance of the Strengths and Difficulties Questionnaire (SDQ), self-reported version, in five European countries. The sample consisted of 3012 adolescents aged between 12 and 17 years (M = 14.20; SD = 0.83). The five-factor model (with correlated errors added), and the five-factor model (with correlated errors added) with the reverse-worded items allowed to cross-load on the Prosocial subscale, displayed adequate goodness of-fit indices. Multi-group confirmatory factor analysis showed that the five-factor model (with correlated errors added) had partial strong measurement invariance by countries. A total of 11 of the 25 items were non-invariant across samples. The level of internal consistency of the Total difficulties score was 0.84, ranging between 0.69 and 0.78 for the SDQ subscales. The findings indicate that the SDQ's subscales need to be modified in various ways for screening emotional and behavioural problems in the five European countries that were analysed.

[ES] El progresivo avance del Derecho de familia hacia reconocimiento de su autonomía de la voluntad corre paralelo al desarrollo de sus límites; constituidos fundamentalmente por los límites nacidos de los principios constitucionales de igualdad de los cónyuges en el matrimonio y por los límites derivados de la configuración del matrimonio como institución, abarcando las normas imperativas referentes a los deberes entre cónyuges y las causas de separación. Entre las expresiones de la autonomía de la voluntad antes de la crisis matrimonial encontramos los acuerdos prematrimoniales. Se trata de pactos entre los cónyuges alcanzados antes y después de contraer matrimonio, pero antes de producirse la crisis y que son condicionales, es decir, dependen de la existencia de una crisis conyugal; y preventivos, esto es, anticipan los problemas o conflictos que puedan surgir ante la eventual crisis, [EN] The progressive advancement of the family law towards recognition of its autonomy runs parallel to the development of its limits; constituted mainly by the limits of the constitutional principles of equality of the spouses in the marriage and the limits deriving from the configuration of marriage as an institution, covering the mandatory regulations regarding the duties between spouses and the causes of separation. Expressions of autonomy of the will before the marriage crisis include premarital agreements. It is pacts between the spouses reached before and after marriage, but before the crisis and which are conditional, i.e. they depend on the existence of a marital crisis; and prevention, that is, they anticipate problems or conflicts that may arise before the eventual crisis., Tesis Univ. Jaén. Departamento de Derecho Civil y Derecho Financiero y Tributario. Leída el 10 de junio de 2013

The development of the planning of academic units is an important activity within the undergraduate teaching process defined in the Quality Management System at ESPOL, since the registration process for each academic term depends directly on this planning. Until now, academic planning of the Faculty of Electrical and Computer Engineering (FIEC) has been developed using basic utility programs that do not offer enough support to the dean, area coordinators and career coordinators, in terms of collaboration among them, reference to historical data, editing of class and activity planning, and correction of schedule conflicts. This article presents a software solution based on web technologies and business process management, which increases the productivity of the actors involved in the planning of classes, schedules and activities of teachers in

Este proyecto ayuda a resolver el problema de organización de espacio en una bodega, es decir, permite organizar los productos de tal manera que el espacio físico disponible en la bodega se lo pueda utilizar eficientemente. No es un manejador de inventario de productos, sino un complemento. Para resolver el problema de organización del espacio físico de una Bodega, se realizó lo siguiente: - Dentro de la Bodega, se crean lugares de almacenamiento denominados Perchas. Estas Perchas tienen 3 dimensiones espaciales: alto, ancho y profundidad. - Dentro de las Perchas, se crean nuevos lugares de almacenamiento denominados SubPechas. Igualmente estas SubPerchas tienen 3 dimensiones espaciales: alto, ancho, profundidad. Se tiene la siguiente restricción: las dimensiones de las SubPerchas no pueden exceder a la de las Perchas, esto es manejado internamente por el sistema. - Se requiere que los productos sean manejados como cajas de productos, con dimensiones de alto, ancho y profundidad. - Las cajas de productos serán asignadas a las SubPerchas, considerando el volumen máximo disponible en las SubPerchas, esto es manejado internamente por el sistema. - No se permite que a una SubPercha se le asigne diferentes tipos de productos, es decir, una SubPercha solo almacena un mismo tipo de producto con iguales dimensiones de las cajas. El proyecto fue desarrollado con tecnología web, bajo la especificación J2EE. Está dividido en 9 módulos, 2 de los cuáles son desarrollados para que puedan ser utilizados por dispositivos PDA que tengan acceso a red inalámbrica a través del protocolo 802.11b/g y posean un navegador incorporado.

Eina que facilita al màxim totes les tasques de gestió tant de les entitats que pertanyen a la coordinadora d'ONG de Lleida com a la pròpia coordinadora. Herramienta que facilita al máximo todas las tareas de gestión tanto de las entidades que pertenecen a la coordinadora de ONG de Lleida como a la propia coordinadora. Tool that simplifies management tasks to the fullest possible extent, both for the entities that are connected to the coordinator of the NGO of Lleida and for the coordinating body itself.

Se redacta el presente proyecto, con el propósito de realizar un dispositivo electrónico que monitorice en un Smartphone, la finalización de los procesos de los electrodomésticos de una vivienda. El objeto de este proyecto, es el desarrollo de un prototipo que sea capaz de obtener y tratar los datos del consumo de los electrodomésticos y una vez que hayan finalizado el proceso seleccionado, enviar a través de una señal inalámbrica al terminal móvil el aviso de finalización. El diseño del presente prototipo busca los siguientes resultados: • Analizar la información suministrada por los sensores mediante un microcontrolador. • Enviar una señal inalámbrica a una centralita y ésta al router, indicando que el programa ha finalizado. • El router se comunicará con el dispositivo móvil y a través de una aplicación mostrará en la pantalla los diferentes avisos