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2. Sexualized drug use, risky sexual behaviors, and prevention strategies among gay, bisexual, and other men who have sex with men.

Author

Íncera-Fernández, Daniel, Román-González, F. Javier, Moreno-Guillén, Santiago, and Gámez-Guadix, Manuel

Subjects
PREVENTION of sexually transmitted diseases, HIV prevention, SEXUALLY transmitted disease diagnosis, SUBSTANCE abuse, SEXUAL partners, RISK-taking behavior, RESEARCH funding, HUMAN sexuality, LGBTQ+ people, DISEASE prevalence, AGE distribution, DESCRIPTIVE statistics, SEX customs, MEN who have sex with men, PRE-exposure prophylaxis, CONDOMS, SOCIODEMOGRAPHIC factors
Abstract

This study aimed to analyze the prevalence of sexualized drug use (SDU) and determine its association with a comprehensive set of sociodemographic characteristics, risky sexual behaviors, prevention measures for human immunodeficiency virus (HIV) and other sexually transmitted infections (STI), and STI diagnosis in Spain. The sample consisted of 493 men who have sex with men between 18 and 78 years old (M age = 32.58, SD = 11.05). Approximately 37.9% of the participants had participated in SDU. Participants who practiced SDU were significantly more likely to be older and have more casual sexual partners and engage in less conventional sexual practices than those who did not. In addition, SDU was associated with less consistent condom use and greater use of Pre-Exposure Prophylaxis (PrEP) compared to participants who did not practice SDU. Finally, the STI diagnosis was also significantly related to SDU. However, when condom use and PrEP was included and controlled in the model along with STI diagnosis, SDU was no longer related to a higher likelihood of STI diagnosis. These results reveal the need to strengthen programs to foster risk-reduction behaviors and reduce the incidence of health implications associated with SDU. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Author

Aznar Muñoz, Esther, Gil Divasson, Pedro, González Muñiz, Patricia, Muñoz Aguirre, Clara, Díaz Menéndez, Marta, de la Calle Prieto, Fernando, Arsuaga Vicente, Marta, Trigo Esteban, Elena, Pérez Valero, Ignacio, de Miguel Buckley, Rosa, Cadiñaños Loidi, Julen, Diaz Pollan, Beatriz, Martín Carbonero, Luz, Ramos Ramos, Juan Carlos, Loeches Yagüe, Belén, Montejano Sánchez, Rocío, González García, Juan, García Rodríguez, Julio, Berenguer, Juan, Ramírez, Margarita, Gutiérrez, Isabel, Tejerina, Francisco, Aldámiz-Echevarría, Teresa, Díez, Cristina, Fanciulli, Chiara, Pérez-Latorre, Leire, Pinilla, Blanca, López, Juan Carlos, Such Diaz, Ana, Álvaro Alonso, Elena, Torres Macho, Juan, Cuevas Tascon, Guillermo, Jiménez González de Buitrago, Eva, Brañas Baztán, Fátima, Valencia de la Rosa, Jorge, Pérez Butragueño, Mario, Fernández Jiménez, Inés, Muñiz Nicolás, Gemma, Sepúlveda Berrocal, Antonia, Gato Díez, Alberto, Toledano Sierra, María Pilar, García Butenegro, María Paz, Peláez Ballesta, Ana Isabel, Morcillo Rodríguez, Elena, Fernández Romero, Isidoro, Peláez Ballesta, Cristina, Guirado Torrecillas, María Isabel, Goikoetxea Agirre, Josune, Bereciartua Bastarrica, Elena, Guio Carrión, Laura, Rodríguez Álvarez, Regino, Ibarrola Hierro, Marta, Pérez Hernández, Isabel A., Pérez Zapata, Inés, Román Soto, Sergio, Kallouchi, Mohamed, Domínguez Vicent, Juan Ramón, Silvariño Fernández, Rafae, Ugalde Espiñeira, Jon, Sanjuan López, Ainhoa, García Martínez, Silvia, Temprano Gogenola, Mikel, Asensi, Víctor, Suárez, Silvia, Suárez, Lucia, Yllera, Carmen, Rivas-Carmenado, María, Romero-Palacios, Alberto, Ruiz Aragón, Jesús, Jiménez Aguilar, Patricia, Fernández Ávila, Ma Luisa, Castilla Ortiz, Rosario, Alende Castro, Vanesa, Pérez García, Cristina, Fernández Morales, Marta, Valle Feijoo Begoña Rodríguez Ferreira, María Lorena María, Gómez-Junyent, Joan, Villar-García, Judit, López-Montesinos, Inmaculada, Arrieta-Aldea, Itziar, Rial-Villavecchia, Abora, García Vázquez, Elisa, Roura Piloto, Aychel Elena, Moral Escudero, Encarnación, Hernández Torres, Alicia, Albendín Iglesias, Helena, Vinuesa García, David, Martínez Montes, Clara, De la Hera Fernández, Francisco Javier, Anguita Santos, Francisco, Ruiz Sancho, Andrés, Díaz de Brito Fernández, Vicens, Sanmarti Vilamala, Montserrat, España Cueto, Sergio, Molina Morant, Daniel, González-Cuevas, Araceli, Chara Cervantes, Joel Elías, Policarpo Torres, Guillem, Ortega Montoliu, Meritxell, Angerri Nadal, Mònica, De Genover Gil, Ariadna, Patera, Eleni, Godoy Lorenzo, Rita, Zioga, Evangelia Anna María, Isern Fernández, Virginia, Sabbagh Fajardo, Carlos Enrique, Ferrer Ribera, Ana, Bea Serrano, Carlos, Oltra Sempere, Rosa, Vela Bernal, Sara, Albiol Viñals, Paloma, Pedromingo Kus, Miguel, Garcinuño, María Ángeles, Fiorante, Silvana, Pérez Pinto, Sergio, de la Vega, Alexandra, Fariñas Álvarez, María Carmen, González Rico, Claudia, Arnaiz de las Revillas, Francisco, Giménez, Teresa, Calvo, Jorge, Meije Castillo, Yolanda, Duarte Borges, Alejandra, Pareja Coca, Júlia, Clemente Presas, Mercedes, Sanz Salvador, Xavier, Pérez Rodríguez, Ma Teresa, Sousa, Adrián, Pérez González, Alexandre, Longueira, Rebeca, Araujo, Alejandro, Alonso Martínez, Blanca, García Escudero, Laura, Lidia Kamel Rey, Sara, Roa Alonso, David, Avilés Parra, Juan Pablo, Pelegrín Senent, Iván, Rouco Esteves Marques, Rosana, Raich Montiu, Laia, Souto Higueras, Jessica, Gálvez Bobadilla, Manuel Alejandro, Parra Ruiz, Jorge, Ramos Sesma, Violeta, Velasco Fuentes, Sara, García Pereña, Laura, Lluna Carrascosa, Alfonso, Gilaberte Reyzábal, Sergio, Liébana Gómez, Mónica, Salillas Hernando, Juan, Serrano Martínez, Alberto, Torralba González de Suso, Miguel, Martínez Martín, Patricia, Rábago Lorite, Isabel, González-Ruano Pérez, Patricia, Pérez-Monte Mínguez, Beatriz, García Flores, Ángeles, Comas Casanova, Pere, Martín Plata, Andrea, Santana Báez, Sergio Manuel, Sanz Peláez, Oscar, Mohamed Ramírez, Karim, Robaina Bordón, José María, Vílchez Rueda, Helem Haydeé, Riera Jaume, Melchor, Mut Ramon, Gemma, Gavalda Manso, Meritxell, Planas Bibiloni, Lluis, Castelo Corral, Laura, Ramos Merino, Lucía, Sánchez Vidal, Efrén, Rodríguez Mayo, María, Míguez Rey, Enrique, García de Lomas Guerrero, José M., De la Torre Lima, Javier, Correa Ruiz, Ana, Fernández Sánchez, Fernando, Jiménez-García, Nicolás, Sierra-Monzón, José Luis, Gracia-Tello, Borja, Hernández-Bonaga, María, Pellejero, Galadriel, Asín-Corrochano, Marta, Boix Palop, Lucia, Calbo, Esther, Badía, Cristina, Dietl, Beatriz, Lucía, Gómez, Domínguez-Castellano, Ángel, Ríos-Villegas, María José, del Toro, María D., Palacios Baena, Zaira R., Salamanca-Rivera, Elena, Marín, Elena, Almadana, Virginia, Pérez-Galera, Salvador, González-Iglesias, Luisa, Abelenda-Alonso, Gabriela, Álvarez-Pouso, Claudia, Escrihuela, Francesc, Gudiol, Carlota, Lorenzo-Esteller, Laia, Niubó, Jordi, Podzamczer, Daniel, Pujol, Miquel, Rombauts, Alexander, Salvert Lletí, Miguel, Gil Sánchez, Ricardo, Jiménez Escrig, Marta, Parra Gómez, Laura, Tasias Pitarch, Mariona, Navarro Vilasaró, Marta, Machado Sicilia, María Luisa, Gomila Grange, Aina, Calzado Isbert, Sonia, Carrasco Antón, Nerea, Petkova-Saiz, Elizabet, Cabello Úbeda, Alfonso, Górgolas Hernández-Mora, Miguel, Sánchez-Pernaute, Olga, Dueñas Gutiérrez, Carlos, Martin Guerra, Javier, Castrodeza Sanz, José Javier, Fernández Espinilla, Virginia, Rodríguez Fernández, Laura, González-Moreno, Juan, Villoslada Gelabert, Aroa, Ribot Sanso, María Antonia, Fernández-Baca, María Victoria, Hernández Milian, Almudena, Morán Rodríguez, Miguel Ángel, Ortiz de Zárate Ibarra, Zuriñe, Portu Zapirain, José Joaquin, Saez de Adana Arroniz, Ester, Gainzarain Arana, Juan Carlos, Meca Birlanga, Olga, del Amor Espín, Ma Jesús, Viqueira González, Montserrat, García García, Josefina, Martínez Madrid, Onofre, Bernal Morell, Enrique, Alcaraz, Antonia, Muñoz, Ángeles, Pina, Ignacio, de la Rosa, Vicente, Caínzos Romero, Tamara, Sánchez Trigo, Sabela, Mariño Callejo, Ana Isabel, Álvarez Díaz, Hortensia, Valcarce Pardeiro, Nieves, Sánchez Serrano, Adriana, Piñar Cabezos, Diana, García Villalba, Eva Pilar, Aguayo Jiménez, Carmen, Ruíz Campuzano, María, Naranjo Velasco, Virginia, Santos Peña, Marta, Mora Delgado, Juan, Sevilla Moreno, Israel, Lojo Cruz, Cristina, Kortajarena Urkola, Xabier, Iribarren Loyarte, José Antonio, Bustinduy Odriozola, María Jesús, Ibarguren Pinilla, Maialen, Álvarez Rodríguez, Ignacio, Martínez Marcos, Francisco Javier, Rodríguez Gómez, Francisco Javier, Asschert Agüero, Isabel, Muñoz Beamud, Francisco, Ruiz Reina, Antonio José, Llenas-García, Jara, González-Cuello, Inmaculada, Hellín-Valiente, Elena, Martínez Birlanga, Esther, Tafalla Torres, José Manuel, Calderón Parra, Jorge, Escudero López, Gabriela, Gutiérrez Martín, Isabel, Andrés Eisenhofer, Ane, García Prieto, Sonia, Álvarez Franco, Raquel, Roger Zapata, Daniel, Martínez Cifre, Blanca, Aranda Rife, Elena, Martín Rubio, Irene, Barbosa Ventura, André, Garrido, Javier, Gonzalo, Concepción, Piñero, Iván, de la Cruz Felipe, Nieves, Talavera García, Eva, Lamata Subero, Marta, Mendoza Roy, Paula, García de Carlos, María Soledad, Lajusticia Aisa, Justo, Arteche Eguizabal, Lorea, Urrutia Losada, Ainhoa, Domingo Echaburu, Saioa, Cuadros Tito, Pedro Ángel, Orbe Narváez, Gurutz, Liébana Martos, Ma del Carmen, Roldán Fontana, Carolina, Herrero Rodríguez, Carmen, Duro Ruiz, Gaspar, Pérez Parra, Santiago, Mera Fidalgo, Arantzazu, Hortos Alsina, Miquel, Alberich Conesa, Ana, Bladé Vidal, Lourdes, Merchante Gutiérrez, Nicolás, León Jiménez, Eva, Espíndola Gómez, Reinaldo, Erostarbe Gallardo, María, Martínez Pérez-Crespo, Pedro, Cisneros, José Miguel, Aguilar-Guisado, Manuela, Aldabó, Teresa, Bueno, Claudio, Cordero-Matía, Elisa, Escoresca, Ana, Infante, Carmen, Guillermo, Martín, Salto, Sonsoles, Gioia, Francesca, Vizcarra, Pilar, Fortún Abete, Jesús, Martín Dávila, Pilar, Moreno Guillén, Santiago, Oteo Revuelta, José A., García-García, Concepción, Santibañez Sáenz, Paula, Cervera Acedo, Cristina, Azcona Gutiérrez, José M., Reguera Iglesias, José María, Plata Ciezar, Antonio, Valiente de Santis, Lucia, Sobrino Diaz, Beatriz, Ruiz Mesa, Juan Diego, Rodríguez-Baño, Jesús, Pachón, Jerónimo, Carratalà, Jordi, Ryan, Pablo, Jarrín, Inmaculada, Yllescas, María, and Arribas, José Ramón

Published
2021
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5. COVID -19: On the threshold of the fifth year. The situation in Spain

Author

Rodríguez-Artalejo, Fernando, primary, Ruiz-Galiana, Julián, additional, Cantón, Rafael, additional, De Lucas Ramos, Pilar, additional, García-Botella, Alejandra, additional, García-Lledó, Alberto, additional, Hernández-Sampelayo, Teresa, additional, Gómez-Pavón, Javier, additional, González del Castillo, Juan, additional, Martín-Delgado, Mari Cruz, additional, Martín Sánchez, Francisco Javier, additional, Martínez-Sellés, Manuel, additional, Molero García, José María, additional, Moreno Guillén, Santiago, additional, García de Viedma, Darío, additional, and Bouza, Emilio, additional

Published
2023
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6. Tuberculosis in Spain: An opinion paper

Author

Moreno Guillén, Santiago, primary, Rodríguez-Artalejo, Fernando, additional, Ruiz-Galiana, Julián, additional, Cantón, Rafael, additional, De Lucas Ramos, Pilar, additional, García-Botella, Alejandra, additional, García-Lledó, Alberto, additional, Hernández-Sampelayo, Teresa, additional, Gómez-Pavón, Javier, additional, González del Castillo, Juan, additional, Martín-Delgado, Mari Cruz, additional, Martín Sánchez, Francisco Javier, additional, Martínez-Sellés, Manuel, additional, Molero García, José María, additional, Santiago, Begoña, additional, Caminero, José Antonio, additional, Barros, Carlos, additional, García de Viedma, Darío, additional, Martín, Carlos, additional, and Bouza, Emilio, additional

Published
2023
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7. Respiratory syncytial virus: A new era.

Author

Ruiz-Galiana, Julián, Cantón, Rafael, De Lucas Ramos, Pilar, García-Botella, Alejandra, García-Lledó, Alberto, Hernández-Sampelayo, Teresa, Gómez-Pavón, Javier, González del Castillo, Juan, Cruz Martín-Delgado, Mari, Martín Sánchez, Francisco Javier, Martínez-Sellés, Manuel, Molero García, José María, Moreno Guillén, Santiago, Rodríguez-Artalejo, Fernando, Rodríguez Fernandez, Rosa, Kestler, Marta, and Bouza, Emilio

Subjects
RESPIRATORY syncytial virus, PUBLIC health, IMMUNOSUPPRESSIVE agents, PAIN in children, MONOCLONAL antibodies
Abstract

Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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8. COVID -19: On the threshold of the fifth year. The situation in Spain.

Author

Rodríguez-Artalejo, Fernando, Ruiz-Galiana, Julián, Cantón, Rafael, De Lucas Ramos, Pilar, García-Botella, Alejandra, García-Lledó, Alberto, Hernández-Sampelayo, Teresa, Gómez-Pavón, Javier, González del Castillo, Juan, Cruz Martín-Delgado, Mari, Martín Sánchez, Francisco Javier, Martínez-Sellés, Manuel, Molero García, José María, Moreno Guillén, Santiago, García de Viedma, Darío, and Bouza, Emilio

Subjects
COVID-19 pandemic, INTENSIVE care units, ANGIOTENSIN converting enzyme, GENETIC mutation
Abstract

Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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10. Advantages and disadvantages of maintaining the mandatory use of masks in health centers and nursing homes in Spain. How and when is it justified to maintain it?

Author

Martínez-Sellés, Manuel, primary, Martín Sánchez, Francisco Javier, additional, Moreno Guillén, Santiago, additional, Rodríguez-Artalejo, Fernando, additional, Ruiz-Galiana, Julián, additional, Cantón, Rafael, additional, De Lucas Ramos, Pilar, additional, García-Botella, Alejandra, additional, García-Lledó, Alberto, additional, Hernández-Sampelayo, Teresa, additional, Gómez-Pavón, Javier, additional, González del Castillo, Juan, additional, Martín-Delgado, Mari Cruz, additional, Molero García, José María, additional, Santiago, Begoña, additional, Caminero, José Antonio, additional, Barros, Carlos, additional, García de Viedma, Darío, additional, Martín, Carlos, additional, and Bouza, Emilio, additional

Published
2023
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11. Sexually transmitted infections in Spain: Current status

Author

Del Romero, Jorge, primary, Moreno Guillén, Santiago, additional, Rodríguez-Artalejo, Fernando, additional, Ruiz-Galiana, Julián, additional, Cantón, Rafael, additional, De Lucas Ramos, Pilar, additional, García-Botella, Alejandra, additional, García-Lledó, Alberto, additional, Hernández-Sampelayo, Teresa, additional, Gómez-Pavón, Javier, additional, González del Castillo, Juan, additional, Martín-Delgado, Mari Cruz, additional, Martín Sánchez, Francisco Javier, additional, Martínez-Sellés, Manuel, additional, Molero García, José María, additional, Gómez Castellá, Javier, additional, Palomo, María, additional, García Berrio, Rocío, additional, Couso González, Aldina, additional, Sotomayor, César, additional, and Bouza, Emilio, additional

Published
2023
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12. What Should Be Known by a Urologist About the Medical Management of COVID-19’s Patients?

Author

Sánchez-González, Álvaro, López-Fando Lavalle, Luis, Esteban-Fernández, Alberto, Ruiz, Mercedes, Hevia, Vital, Comeche, Belén, Sánchez Conde, Matilde, Álvarez, Sara, Lorca Álvaro, Javier, Fraile Poblador, Agustín, Hevia Palacios, Manuel, Domínguez Gutiérrez, Ana, Artiles Medina, Alberto, Sanz Mayayo, Enrique, Duque, Gemma, Gómez Dos Santos, Victoria, Moreno-Guillén, Santiago, and Burgos Revilla, Javier

Published
2020
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13. COVID-19 and geographical area of origin

Author

Vizcarra, Pilar, Norman, Francesca, Crespillo, Clara, Pérez-Molina, José, Comeche, Belén, Chamorro, Sandra, Monge, Begoña, Moreno, Santiago, López-Vélez, Rogelio, Pérez-Elías, Maria Jesús, Fortún, Jesús, Navas, Enrique, Quereda, Carmen, Dronda, Fernando, Del Campo, Santos, Reinoso, Javier Cobo, Casado, José Luis, Moreno, Ana, Martín-Dávila, Pilar, Hermida, José Manuel, Pintado, Vicente, Serrano-Villar, Sergio, Sánchez-Conde, Matilde, Escudero, Rosa, Gioia, Francesca, Herrera, Sabina, Ron, Raquel, Martínez-Sanz, Javier, Pons-Guillén, Mario, Vivancos, María Jesús, Norman, Francesca F., Crespillo-Andújar, Clara, Pérez-Molina, José Antonio, Monge-Maillo, Begoña, and Moreno-Guillén, Santiago

Published
2021
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14. Status of Herpes Zoster and Herpes Zoster Vaccines in 2023: A position paper

Author

Molero García, José María, primary, Moreno Guillén, Santiago, additional, Rodríguez-Artalejo, Fernando, additional, Ruiz-Galiana, Julián, additional, Cantón, Rafael, additional, De Lucas Ramos, Pilar, additional, García-Botella, Alejandra, additional, García-Lledó, Alberto, additional, Hernández-Sampelayo, Teresa, additional, Gómez-Pavón, Javier, additional, González del Castillo, Juan, additional, Martín-Delgado, Mari Cruz, additional, Martín-Sánchez, Francisco Javier, additional, Martínez-Sellés, Manuel, additional, and Bouza, Emilio, additional

Published
2023
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16. Conventional versus extended-pulsed fidaxomicin dosing in patients at high risk of recurrence of Clostridioides difficile infection: a propensity score analysis

Author

Escudero-Sánchez, Rosa, primary, Rubio Martín, Elena, additional, Vizcarra, Pilar, additional, Braojos Sánchez, Francisco, additional, Diaz Gago, Álvaro, additional, Del Campo Albendea, Laura, additional, Muriel, Alfonso, additional, Halperin, Ana, additional, Ponce Alonso, Manuel, additional, Moreno Guillén, Santiago, additional, and Cobo, Javier, additional

Published
2023
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17. A Risk Assessment Tool for Predicting Fragility Fractures in People with HIV: Derivation and Internal Validation of the FRESIA Model.

Author

Vizcarra, Pilar, Moreno, Ana, Vivancos, María J., Muriel García, Alfonso, Ramirez Schacke, Margarita, González‐Garcia, Juan, Curran, Adrián, Palacios, Rosario, Sánchez Guirao, Antonio Jesús, Reus Bañuls, Sergio, Moreno Guillén, Santiago, and Casado, José L.

Abstract

People with HIV have a higher risk of fracture than the general population. Because of the low performance of the existing prediction tools, there is controversy surrounding fracture risk estimation in this population. The aim of the study was to develop a model for predicting the long‐term risk of fragility fractures in people with HIV. We included 11,899 individuals aged ≥30 years from the Spanish HIV/AIDS research network cohort. We identified incident fragility fractures from medical records, defined as nontraumatic or those occurring after a casual fall, at major osteoporotic sites (hip, clinical spine, forearm, proximal humerus). Our model accounted for the competing risk of death and included 12 candidate predictors to estimate the time to first fragility fracture. We assessed the discrimination and calibration of the model and compared it with the FRAX tool. The incidence rate of fragility fractures was 4.34 (95% CI 3.61 to 5.22) per 1000 person‐years. The final prediction model included age, chronic kidney disease, and chronic obstructive pulmonary disease as significant predictors. The model accurately predicted the 5‐ and 10‐year risk of fragility fractures, with an area under the receiving operator characteristic curve of 0.768 (95% CI 0.722 to 0.814) and agreement between the observed and expected probabilities. Furthermore, it demonstrated better discrimination and calibration than the FRAX tool, improving the classification of over 35% of individuals with fragility fractures compared to FRAX. Our prediction model demonstrated accuracy in predicting the long‐term risk of fragility fractures. It can assist in making personalized intervention decisions for individuals with HIV and could potentially replace the current tools recommended for fracture risk assessment in this population. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR). [ABSTRACT FROM AUTHOR]

Published
2023
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18. Insights for COVID-19 in 2023

Author

Martín-Sánchez, Francisco Javier, primary, Martínez-Sellés, Manuel, additional, Molero García, José María, additional, Moreno Guillén, Santiago, additional, Rodríguez-Artalejo, Fernando, additional, Ruiz-Galiana, Julián, additional, Cantón, Rafael, additional, De Lucas Ramos, Pilar, additional, García-Botella, Alejandra, additional, García-Lledó, Alberto, additional, Hernández-Sampelayo, Teresa, additional, Gómez-Pavón, Javier, additional, González del Castillo, Juan, additional, Martín-Delgado, Mari Cruz, additional, and Bouza, Emilio, additional

Published
2022
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19. A feasibility study for 3 strategies promoting HIV testing in primary health care in Madrid, Spain (ESTVIH project)

Author

Domínguez‐Berjón, M. Felicitas, Pichiule‐Castañeda, Myrian, García‐Riolobos, M. Carmen, Esteban‐Vasallo, María D., Arenas‐González, Sonia M., Morán‐Arribas, Mónica, Verdejo‐Ortés, José, Zoni, Ana Clara, Álvarez‐Castillo, M. Carmen, Astray, Jenaro, Aguirre Martín‐Gil, Ramón, Casado López, Mariano, Cevallos García, Carlos, Diezma Criado, Juan Carlos, Granado de la Orden, Susana, Hernández Pascual, Montserrat, Martínez Vidal, Manuel, Moreno Guillén, Santiago, Ordobás Gavín, María, Rico Bermejo, Juan, Ruiz Alonso, Sergio, Zorrilla Torras, Belén, Ferruelo Magán, Manuela, García Valverde, Concepción, López Delgado, María Eugenia, Martínez Gómez, Marta, Martínez Urroz, María Belén, Pascual Malanda, Mercedes, Abad Esteban, Ana María, Alejo Díaz‐Zorita, Concepción, Alfaro León, Gisella, Alonso Martín, M del Pilar, Arbocco Morales, Fabiola María, Bravo Martin, Isabel, Cadenas Giralt, Rosario, Carmena Díaz, Silvia, Castro Pastor, María Luisa, Caudevilla Galligo, Fernando, Cobos López, Cristina, Crespo Fernández, María Rosa, Cruz Pérez, María, Escudero Rodrigo, David, Ferreiro La Sal, Lucia, Ferrer Signes, Miryam, Fortuny Gil, Almudena, García Rabanal, María del Mar, García Rodríguez, Ana Belén, García Soltero, Jesús, Gil Agapito, Paulo, Gómez Neo, Rosa, Góngora Maldonado, Francisco, González Fernández, Cristina, González San Segundo, Rosa María, Grandes Velasco, Sonia, Herrero Martínez, María José, Hidalgo Rodrigo, M. Ángeles, Hurtado La Torre, Reyes, López Uriarte, Beatriz, López‐Hermosa Seseña, Paloma, Martín García, Socorro, Menéndez Álvarez, Susana, Metola Gómez, Montserrat, Molero García, José María, Moreno Puerta, Sara Isabel, Moreno Valencia, Lucía, Muñoz Martínez de Salinas, Cristina, Muros Muñoz, Carmen María, Navarro Mellen, Julia, Orcera Valero, Ana, Prieto Barbosa, Dolores, Quintana Luzón, Celia, Ramos Zamorano, Azucena, Saa Sarria, Rosario, San Feliu Gilabert, M. Teresa, Sánchez Iñigo, Cristina, Sánchez Melero, M. Teresa, Santos Alonso, Belén, Valverde Vadillo, Concepción, Velasco Gutiérrez, Rafaela, Yepes Doblado, M Blanca, and Zamorano Benito, Carmen

Published
2017
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20. Monkeypox in humans: a new outbreak

Author

Martín-Delgado, Mari Cruz, primary, Martín-Sánchez, Francisco Javier, additional, Martínez-Sellés, Manuel, additional, Molero García, José María, additional, Moreno Guillén, Santiago, additional, Rodríguez-Artalejo, Fernando, additional, Ruiz-Galiana, Julián, additional, Cantón, Rafael, additional, De Lucas Ramos, Pilar, additional, García-Botella, Alejandra, additional, García-Lledó, Alberto, additional, Hernández-Sampelayo, Teresa, additional, Gómez-Pavón, Javier, additional, González del Castillo, Juan, additional, Muñoz, Patricia, additional, Valerio, Maricela, additional, Catalán, Pilar, additional, Burillo, Almudena, additional, Cobo, Alejandro, additional, Alcamí, Antonio, additional, and Bouza, Emilio, additional

Published
2022
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21. Lessons from COVID-19 for future disasters: an opinion paper

Author

González del Castillo, Juan, primary, Martín-Delgado, Mari Cruz, additional, Martín-Sánchez, Francisco Javier, additional, Martínez-Sellés, Manuel, additional, Molero García, José María, additional, Moreno Guillén, Santiago, additional, Rodríguez-Artalejo, Fernando, additional, Ruiz-Galiana, Julián, additional, Cantón, Rafael, additional, De Lucas Ramos, Pilar, additional, García-Botella, Alejandra, additional, García-Lledó, Alberto, additional, Hernández-Sampelayo, Teresa, additional, Gómez-Pavón, Javier, additional, and Bouza, Emilio, additional

Published
2022
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22. Insights for COVID-19 in 2023.

Author

Martín Sánchez, Francisco Javier, Martínez-Sellés, Manuel, Molero García, José María, Moreno Guillén, Santiago, Rodríguez-Artalejo, Fernando, Ruiz-Galiana, Julián, Cantón, Rafael, De Lucas Ramos, Pilar, García-Botella, Alejandra, García-Lledó, Alberto, Hernández-Sampelayo, Teresa, Gómez-Pavón, Javier, González del Castillo, Juan, Martín-Delgado, Mari Cruz, and Bouza, Emilio

Subjects
CORONAVIRUS diseases, SARS disease, VACCINATION, INFLUENZA vaccines
Abstract

Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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24. COVID-19: Some unresolved issues

Author

Gómez-Pavón, Javier, primary, González del Castillo, Juan, additional, Martín-Delgado, Mari Cruz, additional, Martín-Sánchez, Francisco Javier, additional, Martínez-Sellés, Manuel, additional, Molero García, José María, additional, Moreno Guillén, Santiago, additional, Rodríguez-Artalejo, Fernando, additional, Ruiz-Galiana, Julián, additional, Cantón, Rafael, additional, De Lucas Ramos, Pilar, additional, García-Botella, Alejandra, additional, García-Lledó, Alberto, additional, Hernández-Sampelayo, Teresa, additional, and Bouza, Emilio, additional

Published
2022
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25. COVID in Pediatric Age: an opinion paper

Author

Hernández-Sampelayo, Teresa, primary, Gómez-Pavón, Javier, additional, González del Castillo, Juan, additional, Martín-Delgado, Mari Cruz, additional, Martín-Sánchez, Francisco Javier, additional, Martínez-Sellés, Manuel, additional, Molero García, José María, additional, Moreno Guillén, Santiago, additional, Rodríguez-Artalejo, Fernando, additional, Ruiz-Galiana, Julián, additional, Cantón, Rafael, additional, De Lucas Ramos, Pilar, additional, García-Botella, Alejandra, additional, García-Lledó, Alberto, additional, Calvo Rey, Cristina, additional, and Bouza, Emilio, additional

Published
2022
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26. Booster or additional vaccination doses in patients vaccinated against COVID-19

Author

García Botella, Alejandra, García Lledó, Alberto, Gómez Pavón, Javier, González del Castillo, Juan, Hernández Sampelayo, Teresa, Martín Delgado, María Cruz, Martín Sánchez, Francisco Javier, Martínez Sellés Oliveria Soares, Manuel, Molero García, José María, and Moreno Guillén, Santiago

Subjects
Infecciones por coronavirus, Paciente, Microbiología, Virus
Abstract

Several health organizations, mainly in Western countries, have recently authorized the use of a booster dose of the COVID-19 vaccine for patients previously vaccinated with mRNA vaccines, with criteria that do not always coincide. The COVID Scientific Committee of the Illustrious College of Physicians of Madrid (ICOMEM) has received and asked several questions about this situation, to which the group has tried to give answers, after deliberation and consensus. The efficacy of the vaccines administered so far is beyond doubt and they have managed to reduce, fundamentally, the severe forms of the disease. The duration of this protection is not well known, is different in different individuals and for different variants of the virus and is not easily predictable with laboratory tests. Data on the real impact of a supplementary or “booster” dose in the scientific literature are scarce for the moment and its application in large populations such as those in the state of Israel may be associated with a decrease in the risk of new and severe episodes in the short observation period available. We also lack sufficient data on the safety and potential adverse effects of these supplementary doses and we do not know the ideal time to administer them in different situations. In this state of affairs, it seems prudent to administer supplemental doses to those exposed to a higher risk, such as immunocompromised individuals and the elderly. On the other hand, we consider that this is not the time to accelerate, on the spur of the moment, a massive administration of a third dose to other population groups that are less exposed and at lower risk, without waiting for adequate scientific information, which will undoubtedly arrive gradually. We do not believe that this position is incompatible with the practical and ethical warnings made by the World Health Organization in this respect. Varias organizaciones sanitarias, fundamentalmente de países occidentales, han autorizado recientemente el uso de una dosis de refuerzo de la vacuna frente al COVID-19 para pacientes previamente vacunados con vacunas mRNA, con cri-terios no siempre coincidentes. El Comité Científico de COVID, del Ilustre Colegio de Méd-icos de Madrid (ICOMEM) ha recibido y se ha formulado diver-sas preguntas sobre esta situación, a la que el grupo ha tratado de dar respuestas, tras deliberación y consenso.La eficacia de las vacunas administradas hasta el momen-to está fuera de toda duda y han logrado disminuir, fundamentales, las formas graves de enfermedad. La duración de esa protección no se conoce bien, es diferente en distintos individuos y para distintas variantes del virus y no es fácil-mente predecible con pruebas de laboratorio.Los datos sobre el impacto real de una dosis complemen-taria o “booster” en la literatura científica son escasos por el momento y su aplicación en grandes poblaciones como las del estado de Israel pueden asociarse a una disminución del riesgo de nuevos episodios y episodios graves en el corto periodo de observación disponible.Carecemos también de datos suficientes sobre la seguri-dad y potenciales efectos adversos de estas dosis complemen-tarias e ignoramos el momento idóneo de administrarlas en distintas situaciones.En este estado de cosas, parece prudente administrar do-sis complementarias a aquellos expuestos a un mayor riesgo, como pueden ser los individuos inmunodeprimidos y las per-sonas mayores. Por el contrario, consideramos que no es este el momento de acelerar improvisadamente una administración masiva de una tercera dosis a otros grupos de población menos expuesta y de menor riesgo, sin esperar la adecuada infor-mación científica, que sin duda irá llegando paulatinamente. No creemos que esta posición, sea incompatible con las advertencias prácticas y éticas que realiza la Organización Mundial de la Salud a este respecto. Sin financiación 2.515 JCR (2021) Q4, 116/136 Microbiology 0.440 SJR (2021) Q4, 1353/2489 Medicine (miscellaneous) No data IDR 2020 UEM

Published
2022

27. Pharmacological treatment of COVID-19: an opinion paper

Author

García Lledó, Alberto, Gómez Pavón, Javier, González del Castillo, Juan, Hernández Sampelayo, Teresa, Martín Delgado, María Cruz, Martín Sánchez, Francisco Javier, Martínez Sellés Oliveria Soares, Manuel, Molero García, José María, Moreno Guillén, Santiago, and Bouza, Emilio

Subjects
Tratamiento médico, Vitamina D, Adalimumab, COVID-19, Enfermedad transmisible, Virus
Abstract

The precocity and efficacy of the vaccines developed so far against COVID-19 has been the most significant and saving advance against the pandemic. The development of vaccines has not prevented, during the whole period of the pandemic, the constant search for therapeutic medicines, both among existing drugs with different indications and in the development of new drugs. The Scientific Committee of the COVID-19 of the Illustrious College of Physicians of Madrid wanted to offer an early, simplified and critical approach to these new drugs, to new developments in immunotherapy and to what has been learned from the immune response modulators already known and which have proven effective against the virus, in order to help understand the current situation. La precocidad y la eficacia de las vacunas desarrolladas hasta ahora frente al COVID-19, ha sido el avance más significativo y salvador frente a la pandemia. El desarrollo vacunal no ha impedido, durante todo el periodo de la pandemia, la búsqueda constante de remedios terapéuticos, tanto entre los medicamentos ya existentes y con indicaciones diversas, como en el desarrollo de nuevos fármacos. Sobre estos nuevos fármacos, sobre las novedades en la inmunoterapia y sobre lo aprendido de los moduladores de la respuesta inmune ya conocidos y que se han mostrado eficaces frente al virus, el Comité Científico del COVID-19 del Ilustre Colegio de Médicos de Madrid ha querido ofrecer una aproximación precoz, simplificada y critica que pueda ayudar a comprender la situación actual. Sin financiación 2.515 JCR (2021) Q3, 206/279 Pharmacology & Pharmacy 0.440 SJR (2021) Q3, 1353/2489 Medicine (miscellaneous) No data IDR 2020 UEM

Published
2022

29. Pharmacological treatment of COVID-19: an opinion paper

Author

García-Lledó, Alberto, primary, Gómez-Pavón, Javier, additional, González del Castillo, Juan, additional, Hernández-Sampelayo, Teresa, additional, Martín-Delgado, Mari Cruz, additional, Martín Sánchez, Francisco Javier, additional, Martínez-Sellés, Manuel, additional, Molero García, José María, additional, Moreno Guillén, Santiago, additional, Rodríguez-Artalejo, Fernando, additional, Ruiz-Galiana, Julián, additional, Cantón, Rafael, additional, De Lucas Ramos, Pilar, additional, García-Botella, Alejandra, additional, and Bouza, Emilio, additional

Published
2021
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30. Booster or additional vaccination doses in patients vaccinated against COVID-19

Author

García-Botella, Alejandra, primary, García-Lledó, Alberto, additional, Gómez-Pavón, Javier, additional, González del Castillo, Juan, additional, Hernández-Sampelayo, Teresa, additional, Martín-Delgado, Mari Cruz, additional, Martín Sánchez, Francisco Javier, additional, Martínez-Sellés, Manuel, additional, Molero García, José María, additional, Moreno Guillén, Santiago, additional, Rodríguez-Artalejo, Fernando, additional, Ruiz-Galiana, Julián, additional, Cantón, Rafael, additional, De Lucas Ramos, Pilar, additional, and Bouza, Emilio, additional

Published
2021
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31. Monkeypox in humans: a new outbreak.

Author

Cruz Martín-Delgado, Mari, Martín Sánchez, Francisco Javier, Martínez-Sellés, Manuel, Molero García, José María, Moreno Guillén, Santiago, Rodríguez-Artalejo, Fernando, Ruiz-Galiana, Julián, Cantón, Rafael, De Lucas Ramos, Pilar, García-Botella, Alejandra, García-Lledó, Alberto, Hernández-Sampelayo, Teresa, Gómez-Pavón, Javier, González del Castillo, Juan, Muñoz, Patricia, Valerio, Maricela, Catalán, Pilar, Burillo, Almudena, Cobo, Alejandro, and Alcamí, Antonio

Subjects
MONKEYPOX virus, RODENTS, ORTHOPOXVIRUSES, LYMPHADENITIS, POLYMERASE chain reaction, PROCTITIS
Abstract

Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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32. Actions and attitudes on the immunized patients against SARS-CoV-2

Author

De Lucas Ramos, Pilar, primary, García-Botella, Alejandra, additional, García-Lledó, Alberto, additional, Gómez-Pavón, Javier, additional, González del Castillo, Juan, additional, Hernández-Sampelayo, Teresa, additional, Martín-Delgado, Mari Cruz, additional, Martín Sánchez, Francisco Javier, additional, Martínez-Sellés, Manuel, additional, Molero García, José María, additional, Moreno Guillén, Santiago, additional, Rodríguez-Artalejo, Fernando, additional, Ruiz-Galiana, Julián, additional, Cantón, Rafael, additional, and Bouza, Emilio, additional

Published
2021
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33. Persistence and viability of SARS-CoV-2 in primary infection and reinfections

Author

Ruiz-Galiana, Julián, primary, De Lucas Ramos, Pilar, additional, García-Botella, Alejandra, additional, García-Lledó, Alberto, additional, Gómez-Pavón, Javier, additional, González del Castillo, Juan, additional, Hernández-Sampelayo, Teresa, additional, Martín-Delgado, Mari Cruz, additional, Martín Sánchez, Francisco Javier, additional, Martínez-Sellés, Manuel, additional, Molero García, José María, additional, Moreno Guillén, Santiago, additional, Rodríguez-Artalejo, Fernando, additional, Cantón, Rafael, additional, and Bouza, Emilio, additional

Published
2021
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34. Vacunación anti-COVID-19: la realidad tras los ensayos clínicos

Author

Ruiz Galiana, Julián, Cantón, Rafael, De Lucas Ramos, Pilar, García Botella, Alejandra, García Lledó, Alberto, Gómez Pavón, Javier, González del Castillo, Juan, Hernández Sampelayo, Teresa, Martín Delgado, María Cruz, Martín Sánchez, Francisco Javier, Martínez Sellés, Manuel, Molero García, José María, Moreno Guillén, Santiago, Rodríguez Artalejo, Fernando, and Bouza, Emilio

Subjects
Vacunas, Efectos adversos, COVID-19
Abstract

Tras el comienzo de la vacunación frente a SARS-CoV-2, se está acumulando ya suficiente experiencia clínica, en el mundo real y fuera de los ensayos clínicos, para resolver algunas de las cuestiones que siguen pendientes sobre este problema. El Comité Científico sobre COVID-19 del Colegio de Médicos de Madrid ha discutido y revisado algunos de estos temas con una aproximación multidisciplinar. El documento que sigue es un intento de responder a algunas de dichas cuestiones con la información disponible hasta el momento. Este documento se ha estructurado en preguntas sobre distintos aspectos de las indicaciones, eficacia y tolerancia de la vacunación anti- COVID-19. post-print 214 KB

Published
2021

35. COVID-19 and geographical area of origin

Author

Norman, Francesca F., primary, Crespillo-Andújar, Clara, additional, Pérez-Molina, José Antonio, additional, Comeche, Belén, additional, Chamorro, Sandra, additional, Monge-Maillo, Begoña, additional, Moreno-Guillén, Santiago, additional, López-Vélez, Rogelio, additional, Vizcarra, Pilar, additional, Norman, Francesca, additional, Crespillo, Clara, additional, Pérez-Molina, José, additional, Monge, Begoña, additional, Moreno, Santiago, additional, Pérez-Elías, Maria Jesús, additional, Fortún, Jesús, additional, Navas, Enrique, additional, Quereda, Carmen, additional, Dronda, Fernando, additional, Del Campo, Santos, additional, Reinoso, Javier Cobo, additional, Casado, José Luis, additional, Moreno, Ana, additional, Martín-Dávila, Pilar, additional, Hermida, José Manuel, additional, Pintado, Vicente, additional, Serrano-Villar, Sergio, additional, Sánchez-Conde, Matilde, additional, Escudero, Rosa, additional, Gioia, Francesca, additional, Herrera, Sabina, additional, Ron, Raquel, additional, Martínez-Sanz, Javier, additional, Pons-Guillén, Mario, additional, and Vivancos, María Jesús, additional

Published
2021
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36. Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Author

Rodríguez-Baño, Jesús, primary, Pachón, Jerónimo, additional, Carratalà, Jordi, additional, Ryan, Pablo, additional, Jarrín, Inmaculada, additional, Yllescas, María, additional, Arribas, José Ramón, additional, Berenguer, Juan, additional, Aznar Muñoz, Esther, additional, Gil Divasson, Pedro, additional, González Muñiz, Patricia, additional, Muñoz Aguirre, Clara, additional, Díaz Menéndez, Marta, additional, de la Calle Prieto, Fernando, additional, Arsuaga Vicente, Marta, additional, Trigo Esteban, Elena, additional, Pérez Valero, Ignacio, additional, de Miguel Buckley, Rosa, additional, Cadiñaños Loidi, Julen, additional, Diaz Pollan, Beatriz, additional, Martín Carbonero, Luz, additional, Ramos Ramos, Juan Carlos, additional, Loeches Yagüe, Belén, additional, Montejano Sánchez, Rocío, additional, González García, Juan, additional, García Rodríguez, Julio, additional, Ramírez, Margarita, additional, Gutiérrez, Isabel, additional, Tejerina, Francisco, additional, Aldámiz-Echevarría, Teresa, additional, Díez, Cristina, additional, Fanciulli, Chiara, additional, Pérez-Latorre, Leire, additional, Pinilla, Blanca, additional, López, Juan Carlos, additional, Such Diaz, Ana, additional, Álvaro Alonso, Elena, additional, Torres Macho, Juan, additional, Cuevas Tascon, Guillermo, additional, Jiménez González de Buitrago, Eva, additional, Brañas Baztán, Fátima, additional, Valencia de la Rosa, Jorge, additional, Pérez Butragueño, Mario, additional, Fernández Jiménez, Inés, additional, Muñiz Nicolás, Gemma, additional, Sepúlveda Berrocal, Antonia, additional, Gato Díez, Alberto, additional, Toledano Sierra, María Pilar, additional, García Butenegro, María Paz, additional, Peláez Ballesta, Ana Isabel, additional, Morcillo Rodríguez, Elena, additional, Fernández Romero, Isidoro, additional, Peláez Ballesta, Cristina, additional, Guirado Torrecillas, María Isabel, additional, Goikoetxea Agirre, Josune, additional, Bereciartua Bastarrica, Elena, additional, Guio Carrión, Laura, additional, Rodríguez Álvarez, Regino, additional, Ibarrola Hierro, Marta, additional, Pérez Hernández, Isabel A., additional, Pérez Zapata, Inés, additional, Román Soto, Sergio, additional, Kallouchi, Mohamed, additional, Domínguez Vicent, Juan Ramón, additional, Silvariño Fernández, Rafae, additional, Ugalde Espiñeira, Jon, additional, Sanjuan López, Ainhoa, additional, García Martínez, Silvia, additional, Temprano Gogenola, Mikel, additional, Asensi, Víctor, additional, Suárez, Silvia, additional, Suárez, Lucia, additional, Yllera, Carmen, additional, Rivas-Carmenado, María, additional, Romero-Palacios, Alberto, additional, Ruiz Aragón, Jesús, additional, Jiménez Aguilar, Patricia, additional, Fernández Ávila, Ma Luisa, additional, Castilla Ortiz, Rosario, additional, Alende Castro, Vanesa, additional, Pérez García, Cristina, additional, Fernández Morales, Marta, additional, Valle Feijoo Begoña Rodríguez Ferreira, María Lorena María, additional, Gómez-Junyent, Joan, additional, Villar-García, Judit, additional, López-Montesinos, Inmaculada, additional, Arrieta-Aldea, Itziar, additional, Rial-Villavecchia, Abora, additional, García Vázquez, Elisa, additional, Roura Piloto, Aychel Elena, additional, Moral Escudero, Encarnación, additional, Hernández Torres, Alicia, additional, Albendín Iglesias, Helena, additional, Vinuesa García, David, additional, Martínez Montes, Clara, additional, De la Hera Fernández, Francisco Javier, additional, Anguita Santos, Francisco, additional, Ruiz Sancho, Andrés, additional, Díaz de Brito Fernández, Vicens, additional, Sanmarti Vilamala, Montserrat, additional, España Cueto, Sergio, additional, Molina Morant, Daniel, additional, González-Cuevas, Araceli, additional, Chara Cervantes, Joel Elías, additional, Policarpo Torres, Guillem, additional, Ortega Montoliu, Meritxell, additional, Angerri Nadal, Mònica, additional, De Genover Gil, Ariadna, additional, Patera, Eleni, additional, Godoy Lorenzo, Rita, additional, Zioga, Evangelia Anna María, additional, Isern Fernández, Virginia, additional, Sabbagh Fajardo, Carlos Enrique, additional, Ferrer Ribera, Ana, additional, Bea Serrano, Carlos, additional, Oltra Sempere, Rosa, additional, Vela Bernal, Sara, additional, Albiol Viñals, Paloma, additional, Pedromingo Kus, Miguel, additional, Garcinuño, María Ángeles, additional, Fiorante, Silvana, additional, Pérez Pinto, Sergio, additional, de la Vega, Alexandra, additional, Fariñas Álvarez, María Carmen, additional, González Rico, Claudia, additional, Arnaiz de las Revillas, Francisco, additional, Giménez, Teresa, additional, Calvo, Jorge, additional, Meije Castillo, Yolanda, additional, Duarte Borges, Alejandra, additional, Pareja Coca, Júlia, additional, Clemente Presas, Mercedes, additional, Sanz Salvador, Xavier, additional, Pérez Rodríguez, Ma Teresa, additional, Sousa, Adrián, additional, Pérez González, Alexandre, additional, Longueira, Rebeca, additional, Araujo, Alejandro, additional, Alonso Martínez, Blanca, additional, García Escudero, Laura, additional, Lidia Kamel Rey, Sara, additional, Roa Alonso, David, additional, Avilés Parra, Juan Pablo, additional, Pelegrín Senent, Iván, additional, Rouco Esteves Marques, Rosana, additional, Raich Montiu, Laia, additional, Souto Higueras, Jessica, additional, Gálvez Bobadilla, Manuel Alejandro, additional, Parra Ruiz, Jorge, additional, Ramos Sesma, Violeta, additional, Velasco Fuentes, Sara, additional, García Pereña, Laura, additional, Lluna Carrascosa, Alfonso, additional, Gilaberte Reyzábal, Sergio, additional, Liébana Gómez, Mónica, additional, Salillas Hernando, Juan, additional, Serrano Martínez, Alberto, additional, Torralba González de Suso, Miguel, additional, Martínez Martín, Patricia, additional, Rábago Lorite, Isabel, additional, González-Ruano Pérez, Patricia, additional, Pérez-Monte Mínguez, Beatriz, additional, García Flores, Ángeles, additional, Comas Casanova, Pere, additional, Martín Plata, Andrea, additional, Santana Báez, Sergio Manuel, additional, Sanz Peláez, Oscar, additional, Mohamed Ramírez, Karim, additional, Robaina Bordón, José María, additional, Vílchez Rueda, Helem Haydeé, additional, Riera Jaume, Melchor, additional, Mut Ramon, Gemma, additional, Gavalda Manso, Meritxell, additional, Planas Bibiloni, Lluis, additional, Castelo Corral, Laura, additional, Ramos Merino, Lucía, additional, Sánchez Vidal, Efrén, additional, Rodríguez Mayo, María, additional, Míguez Rey, Enrique, additional, García de Lomas Guerrero, José M., additional, De la Torre Lima, Javier, additional, Correa Ruiz, Ana, additional, Fernández Sánchez, Fernando, additional, Jiménez-García, Nicolás, additional, Sierra-Monzón, José Luis, additional, Gracia-Tello, Borja, additional, Hernández-Bonaga, María, additional, Pellejero, Galadriel, additional, Asín-Corrochano, Marta, additional, Boix Palop, Lucia, additional, Calbo, Esther, additional, Badía, Cristina, additional, Dietl, Beatriz, additional, Lucía, Gómez, additional, Domínguez-Castellano, Ángel, additional, Ríos-Villegas, María José, additional, del Toro, María D., additional, Palacios Baena, Zaira R., additional, Salamanca-Rivera, Elena, additional, Marín, Elena, additional, Almadana, Virginia, additional, Pérez-Galera, Salvador, additional, González-Iglesias, Luisa, additional, Abelenda-Alonso, Gabriela, additional, Álvarez-Pouso, Claudia, additional, Escrihuela, Francesc, additional, Gudiol, Carlota, additional, Lorenzo-Esteller, Laia, additional, Niubó, Jordi, additional, Podzamczer, Daniel, additional, Pujol, Miquel, additional, Rombauts, Alexander, additional, Salvert Lletí, Miguel, additional, Gil Sánchez, Ricardo, additional, Jiménez Escrig, Marta, additional, Parra Gómez, Laura, additional, Tasias Pitarch, Mariona, additional, Navarro Vilasaró, Marta, additional, Machado Sicilia, María Luisa, additional, Gomila Grange, Aina, additional, Calzado Isbert, Sonia, additional, Carrasco Antón, Nerea, additional, Petkova-Saiz, Elizabet, additional, Cabello Úbeda, Alfonso, additional, Górgolas Hernández-Mora, Miguel, additional, Sánchez-Pernaute, Olga, additional, Dueñas Gutiérrez, Carlos, additional, Martin Guerra, Javier, additional, Castrodeza Sanz, José Javier, additional, Fernández Espinilla, Virginia, additional, Rodríguez Fernández, Laura, additional, González-Moreno, Juan, additional, Villoslada Gelabert, Aroa, additional, Ribot Sanso, María Antonia, additional, Fernández-Baca, María Victoria, additional, Hernández Milian, Almudena, additional, Morán Rodríguez, Miguel Ángel, additional, Ortiz de Zárate Ibarra, Zuriñe, additional, Portu Zapirain, José Joaquin, additional, Saez de Adana Arroniz, Ester, additional, Gainzarain Arana, Juan Carlos, additional, Meca Birlanga, Olga, additional, del Amor Espín, Ma Jesús, additional, Viqueira González, Montserrat, additional, García García, Josefina, additional, Martínez Madrid, Onofre, additional, Bernal Morell, Enrique, additional, Alcaraz, Antonia, additional, Muñoz, Ángeles, additional, Pina, Ignacio, additional, de la Rosa, Vicente, additional, Caínzos Romero, Tamara, additional, Sánchez Trigo, Sabela, additional, Mariño Callejo, Ana Isabel, additional, Álvarez Díaz, Hortensia, additional, Valcarce Pardeiro, Nieves, additional, Sánchez Serrano, Adriana, additional, Piñar Cabezos, Diana, additional, García Villalba, Eva Pilar, additional, Aguayo Jiménez, Carmen, additional, Ruíz Campuzano, María, additional, Naranjo Velasco, Virginia, additional, Santos Peña, Marta, additional, Mora Delgado, Juan, additional, Sevilla Moreno, Israel, additional, Lojo Cruz, Cristina, additional, Kortajarena Urkola, Xabier, additional, Iribarren Loyarte, José Antonio, additional, Bustinduy Odriozola, María Jesús, additional, Ibarguren Pinilla, Maialen, additional, Álvarez Rodríguez, Ignacio, additional, Martínez Marcos, Francisco Javier, additional, Rodríguez Gómez, Francisco Javier, additional, Asschert Agüero, Isabel, additional, Muñoz Beamud, Francisco, additional, Ruiz Reina, Antonio José, additional, Llenas-García, Jara, additional, González-Cuello, Inmaculada, additional, Hellín-Valiente, Elena, additional, Martínez Birlanga, Esther, additional, Tafalla Torres, José Manuel, additional, Calderón Parra, Jorge, additional, Escudero López, Gabriela, additional, Gutiérrez Martín, Isabel, additional, Andrés Eisenhofer, Ane, additional, García Prieto, Sonia, additional, Álvarez Franco, Raquel, additional, Roger Zapata, Daniel, additional, Martínez Cifre, Blanca, additional, Aranda Rife, Elena, additional, Martín Rubio, Irene, additional, Barbosa Ventura, André, additional, Garrido, Javier, additional, Gonzalo, Concepción, additional, Piñero, Iván, additional, de la Cruz Felipe, Nieves, additional, Talavera García, Eva, additional, Lamata Subero, Marta, additional, Mendoza Roy, Paula, additional, García de Carlos, María Soledad, additional, Lajusticia Aisa, Justo, additional, Arteche Eguizabal, Lorea, additional, Urrutia Losada, Ainhoa, additional, Domingo Echaburu, Saioa, additional, Cuadros Tito, Pedro Ángel, additional, Orbe Narváez, Gurutz, additional, Liébana Martos, Ma del Carmen, additional, Roldán Fontana, Carolina, additional, Herrero Rodríguez, Carmen, additional, Duro Ruiz, Gaspar, additional, Pérez Parra, Santiago, additional, Mera Fidalgo, Arantzazu, additional, Hortos Alsina, Miquel, additional, Alberich Conesa, Ana, additional, Bladé Vidal, Lourdes, additional, Merchante Gutiérrez, Nicolás, additional, León Jiménez, Eva, additional, Espíndola Gómez, Reinaldo, additional, Erostarbe Gallardo, María, additional, Martínez Pérez-Crespo, Pedro, additional, Cisneros, José Miguel, additional, Aguilar-Guisado, Manuela, additional, Aldabó, Teresa, additional, Bueno, Claudio, additional, Cordero-Matía, Elisa, additional, Escoresca, Ana, additional, Infante, Carmen, additional, Guillermo, Martín, additional, Salto, Sonsoles, additional, Gioia, Francesca, additional, Vizcarra, Pilar, additional, Fortún Abete, Jesús, additional, Martín Dávila, Pilar, additional, Moreno Guillén, Santiago, additional, Oteo Revuelta, José A., additional, García-García, Concepción, additional, Santibañez Sáenz, Paula, additional, Cervera Acedo, Cristina, additional, Azcona Gutiérrez, José M., additional, Reguera Iglesias, José María, additional, Plata Ciezar, Antonio, additional, Valiente de Santis, Lucia, additional, Sobrino Diaz, Beatriz, additional, and Ruiz Mesa, Juan Diego, additional

Published
2021
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37. Pharmacological treatment of COVID-19: an opinion paper.

Author

García-Lledó, Alberto, Gómez-Pavón, Javier, González del Castillo, Juan, Hernández-Sampelayo, Teresa, Cruz Martín-Delgado, Mari, Martín Sánchez, Francisco Javier, Martínez-Sellés, Manuel, Molero García, José María, Moreno Guillén, Santiago, Rodríguez-Artalejo, Fernando, Ruiz-Galiana, Julián, Cantón, Rafael, De Lucas Ramos, Pilar, García-Botella, Alejandra, and Bouza, Emilio

Subjects
COVID-19, COVID-19 pandemic, COVID-19 vaccines, THERAPEUTICS, PHYSICIANS
Abstract

Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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38. Booster or additional vaccination doses in patients vaccinated against COVID-19.

Author

García-Botella, Alejandra, García-Lledó, Alberto, Gómez-Pavón, Javier, González del Castillo, Juan, Hernández-Sampelayo, Teresa, Cruz Martín-Delgado, Mari, Martín Sánchez, Francisco Javier, Martínez-Sellés, Manuel, Molero García, José María, Moreno Guillén, Santiago, Rodríguez-Artalejo, Fernando, Ruiz-Galiana, Julián, Cantón, Rafael, De Lucas Ramos, Pilar, and Bouza, Emilio

Subjects
BOOSTER vaccines, COVID-19, COVID-19 vaccines, PHYSICIANS, RNA regulation
Abstract

Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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39. Actions and attitudes on the immunized patients against SARS-CoV-2.

Author

De Lucas Ramos, Pilar, García-Botella, Alejandra, García-Lledó, Alberto, Gómez-Pavón, Javier, González del Castillo, Juan, Hernández-Sampelayo, Teresa, Cruz Martín-Delgado, Mari, Martín Sánchez, Francisco Javier, Martínez-Sellés, Manuel, Molero García, José María, Moreno Guillén, Santiago, Rodríguez-Artalejo, Fernando, Ruiz-Galiana, Julián, Cantón, Rafael, and Bouza, Emilio

Subjects
SARS-CoV-2, COVID-19 vaccines, HUMAN beings, SOCIAL distancing, IMMUNE response
Abstract

Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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40. Persistence and viability of SARS-CoV-2 in primary infection and reinfections.

Author

Ruiz-Galiana, Julián, De Lucas Ramos, Pilar, García-Botella, Alejandra, García-Lledó, Alberto, Gómez-Pavón, Javier, González del Castillo, Juan, Hernández-Sampelayo, Teresa, Cruz Martín-Delgado, Mari, Martín Sánchez, Francisco Javier, Martínez-Sellés, Manuel, Molero García, José María, Moreno Guillén, Santiago, Rodríguez-Artalejo, Fernando, Cantón, Rafael, and Bouza, Emilio

Subjects
SARS-CoV-2, IMMUNE response, ANTIBODY formation, HUMAN genome, CLINICAL trials
Abstract

Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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43. New variants of SARS-CoV-2.

Author

Cantón, Rafael, De Lucas Ramos, Pilar, García-Botella, Alejandra, García-Lledó, Alberto, Gómez-Pavón, Javier, González del Castillo, Juan, Hernández-Sampelayo, Teresa, Cruz Martín-Delgado, Mari, Martín Sánchez, Francisco Javier, Martínez-Sellés, Manuel, Molero García, José María, Moreno Guillén, Santiago, Rodríguez-Artalejo, Fernando, Ruiz-Galiana, Julián, and Bouza, Emilio

Subjects
COVID-19, COVID-19 vaccines, DNA sequencing, EPIDEMIOLOGY, PUBLIC health
Abstract

Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
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44. Vacunación anti-COVID-19: La realidad tras los ensayos clínicos.

Author

Ruiz-Galiana, Julián, Cantón, Rafael, De Lucas Ramos, Pilar, García-Botella, Alejandra, García-Lledó, Alberto, Gómez-Pavón, Javier, González del Castillo, Juan, Hernández-Sampelayo, Teresa, Cruz Martín-Delgado, Mari, Martín Sánchez, Francisco Javier, Martínez-Sellés, Manuel, Molero García, José María, Moreno Guillén, Santiago, Rodríguez-Artalejo, Fernando, and Bouza, Emilio

Abstract

Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
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45. Síndrome post-COVID: Un documento de reflexión y opinión.

Author

Bouza, Emilio, Cantón Moreno, Rafael, De Lucas Ramos, Pilar, García-Botella, Alejandra, García-Lledó, Alberto, Gómez-Pavón, Javier, González del Castillo, Juan, Hernández-Sampelayo, Teresa, Cruz Martín-Delgado, Mari, Martín Sanchez, Francisco Javier, Martínez-Sellés, Manuel, Molero García, José María, Moreno Guillén, Santiago, Javier Rodríguez-Artalejo, Francisco, Ruiz-Galiana, Julián, De Pablo Brühlmann, Silvia, Porta Etessam, Jesús, and Santos Sebastián, Mar

Abstract

Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
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47. Organisational and financial consequences of the early discharge of patients treated for acute bacterial skin and skin structure infection and osteomyelitis in infectious disease departments in Greece, Italy and Spain: a scenario analysis

Author

Restelli, Umberto, primary, Bonfanti, Marzia, additional, Croce, Davide, additional, Grau, Santiago, additional, Metallidis, Symeon, additional, Moreno Guillén, Santiago, additional, Pacelli, Valeria, additional, Rizzardini, Giuliano, additional, Soro, Marco, additional, Vozikis, Athanasios, additional, and Gray, Alastair, additional

Published
2019
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48. VIH en España 2017: políticas para una nueva gestión de la cronicidad más allá del control virológico

Author

Gol Montserrat, Jordi, Llano Señaris, Juan E. del, Castaño, Manuel, Hernández, Juan Sebastián, García Goñi, Manuel, Amo Valero, Julia del, Segura Porta, Ferrán, Suárez Lozano, Ignacio, Teira, Ramón, Serrano Villar, Sergio, Moreno Guillén, Santiago, Fernández Giráldez, Elvira, Elizondo Rodríguez, Nerea, Navarro, Gemma, Pujol, Ferran, Fuster Ruiz de Apocada, María Jóse, Blanch, Jordi, Nuño Solinís, Roberto, Campbell, Colin, Brañas, Fátima, Morillo Verdugo, Ramón A., Marco, María Paz, Gol Montserrat, Jordi, Llano Señaris, Juan E. del, Castaño, Manuel, Hernández, Juan Sebastián, García Goñi, Manuel, Amo Valero, Julia del, Segura Porta, Ferrán, Suárez Lozano, Ignacio, Teira, Ramón, Serrano Villar, Sergio, Moreno Guillén, Santiago, Fernández Giráldez, Elvira, Elizondo Rodríguez, Nerea, Navarro, Gemma, Pujol, Ferran, Fuster Ruiz de Apocada, María Jóse, Blanch, Jordi, Nuño Solinís, Roberto, Campbell, Colin, Brañas, Fátima, Morillo Verdugo, Ramón A., and Marco, María Paz

Abstract

The analysis of the available databases related to HIV/AIDS confirms a paradigm shift in the patient’s life expectancy: now HIV has become a chronic disease, so patients are aging. However, this advance is accompanied by a negative counterpart: due to the increase in the number of years of life gained, there is a prevalence of comorbidities greater than the general population and at an earlier age. Reducing the risk associated with all the comorbidities that the ageing patient with HIV/AIDS may develop, must now be a health objective; it must be added to the traditional objectives that until now were part of the strategy to reduce the impact of the HIV infection. In the specific case of women, it is also necessary to train peri and postmenopausal women to increase their skills and motivation to care for their health; It is also very important to examine the role that hormone replacement therapy can play in reducing their symptoms., RESUMEN El análisis de las bases de datos disponibles relacionadas con VIH/SIDA confirma un cambio de paradigma en la esperanza de vida del paciente: ahora el VIH se ha convertido en una enfermedad crónica, con la que los pacientes están envejeciendo. No obstante, este avance se acompaña de una contraparte negativa: debido al incremento en el número de años de vida ganados, se da una prevalencia de comorbilidades mayor a la de la población general y a una edad más temprana. Reducir el riesgo asociado a todas las comorbilidades que puede desarrollar el paciente con VIH/SIDA mientras envejece debe ser hoy en día un objetivo de salud, que se suma a los objetivos tradicionales que hasta ahora formaban parte de la estrategia para reducir el impacto de la infección por el VIH. En el caso específico de la mujer, además es necesario formar a las mujeres peri y postmenopáusicas para incrementar sus habilidades y su motivación para el cuidado de su salud; también es muy importante que se examine el rol que puede tener la terapia de reemplazo hormonal en la reducción de sus síntomas.

Published
2018

49. Pre-exposure prophylaxis (PrEP) against HIV: efficacy, safety and uncertainties

Author

Sánchez-Conde, Matilde, Vivancos, María-Jesús, and Moreno-Guillén, Santiago

Subjects
Efficacy, Eficacia, Pre-exposure prophylaxis, Infección por el VIH, HIV infection, Profilaxis preexposición
Abstract

Despite the global stabilization of the number of new HIV infections in recent years, there has been an increase in new infections among men who have sex with men. This fact indicates the lack of effectiveness of the measures and prevention campaigns established so far for this group. It is therefore necessary to implement alternative preventive measures for them. Pre-exposure pharmacological prophylaxis (PrEP) is one of the best evaluated options and has had high protection rates in both clinical and real-life trials. The strategy has also shown an adequate profile in terms of safety, tolerance, adverse effects and cost-effectiveness in the studies carried out to assess this important topic Resumen En los últimos años se ha objetivado un incremento de las nuevas infecciones por el VIH en el grupo de hombres que tienen sexo con hombres, lo que indica la ausencia de eficacia de las campañas y medidas preventivas instauradas en dicho grupo. Es necesario, por tanto, implementar medidas preventivas alternativas, siendo la profilaxis farmacológica pre-exposición (PrEP) una de las opciones mejor evaluadas tanto en ensayos clínicos como en la vida real, habiéndose demostrado tasas de protección superiores al 80% cuando se administra en los casos indicados y con buen cumplimiento terapeútico. La estrategia ha demostrado, además, un perfil adecuado en seguridad, tolerancia y efectos adversos, siendo además coste-efectiva según los estudios realizados para valorar este importante aspecto.

Published
2017

50. Cost-utility analysis of the fixed-dose combination of dolutegravir/abacavir/lamivudine as initial treatment of HIV+ patients in Spain

Author

Moreno Guillén, Santiago, Losa García, Juan Emilio, Berenguer Berenguer, Juan, Martínez Sesmero, José Manuel, Cenoz Gomis, Santiago, Graefehain, Ruth, Sánchez-Cambronero, David López, and Parrondo García, Francisco Javier

Subjects
Cost-Utility analysis, Análisis coste-utilidad, Tratamiento del VIH, HIV treatment, Computer simulation, Simulación por ordenador
Abstract

Objective: Fixed-dose combinations of antiretroviral drugs have meant an important step forward in simplifying treatment and improving com-pliance and has led to an increased effectiveness of therapy, a viral load decrease and improving the quality of life of patients. The single-table formulation of dolutegravir with abacavir and lamivudine (DTG/ABC/3TC) is a highly efficacious and well -tolerated once-daily re-gimen for HIV-infected patients. The objective of the study was to assess the incremental cost-utility ratio of the fixed-dose combination of (DTG/ ABC/3TC) versus the combinations emtricitabine/tenofovir/efavirenz (FTC/TDF/EFV), and darunavir/r (DRV/r) or raltegravir (RAL) with emtrici-tabine/tenofovir (FTC/TDF) or abacavir/lamivudine (ABC/3TC) as initial antiretroviral therapy in patients infected with HIV-1 from the perspective of the Spanish National Health System. Method: The ARAMIS model, which uses a microsimulation approach to simulate the individual changes in each patient from the start of treatment to death through a Markov chain of descriptive health states of the disease, was adapted to Spain. The alternatives used for comparison were the fixed- dose combination of emtricitabine/tenofovir/efavirenz (FTC/TDF/ EFV), and the fixed-dose combinations of emtricitabine/tenofovir (FTC/ TDF) or abacavir/lamivudine (ABC/3TC) with darunavir/r (DRV/r) or ral-tegravir (RAL). The probability of achieving virological suppression by the treatments included in the model was obtained from clinical trials SINGLE, SPRING-2 and FLAMINGO and the costs were expressed in € (2015). The model use the perspective of the Spanish National Health System, with a lifetime horizon and a discount rate of 3% was applied to cost and effectiveness. Results: Treatment initiation with DTG/ABC/3TC was dominant when it was compared with treatment initiation with all the comparators: vs. FTC/TDF/EFV (-67 210.71€/QALY), vs. DRV/r + FTC/TDF or ABC/3TC (-1 787 341.44€/QALY), and vs. RAL + FTC/TDF or ABC/3TC (-1 005 117.13€/QALY). All the sensitivity analyses performed showed the consistency of these findings. Conclusions: With the premises considered, treatment initiation with DTG/ABC/3TC STR appears to be the most cost-effective option in ART-naïve HIV infected patients from the Spanish Health System perspective. Resumen Objetivo: Las combinaciones a dosis fijas de medicamentos antirretro-virales han significado un importante paso adelante en la simplificación del tratamiento y la mejora del cumplimiento, así como hacia una mayor eficacia de la terapia, una disminución de la carga viral y una mejora de la calidad de vida de los pacientes. La formulación de un comprimido único una vez al día con dosis fijas de dolutegravir, abacavir y lamivudina (DTG/ABC/3TC) para pacientes infectados con VIH es un régimen altamente eficaz y bien tolerado. El objetivo del estudio fue evaluar la relación coste-utilidad incremental de la combinación de dosis fija de (DTG/ABC/3TC) versus las combina-ciones de emtricitabina/tenofovir/efavirenz (TDF/FTC/EFV) y darunavir/r (DRV/r) o raltegravir (RAL) con emtricitabina/tenofovir (FTC/TDF) o aba-cavir/lamivudina (ABC/3TC) como tratamiento antirretroviral inicial en pacientes infectados con VIH-1 desde la perspectiva del Sistema Nacio-nal de Salud Español. Método: Se adaptó en España el modelo ARAMIS. Este utiliza un en-foque de microsimulación para emular los cambios individuales en cada paciente desde el inicio del tratamiento hasta su muerte mediante una ca-dena de Markov de estados de salud descriptivos de la enfermedad. Las alternativas empleadas para la comparación fueron la combinación de dosis fijas de emtricitabina/tenofovir/efavirenz (TDF/FTC/EFV) y las com-binaciones de dosis fijas de emtricitabina/tenofovir (FTC/TDF) o abaca-vir/lamivudina (ABC/3TC) con darunavir/r (DRV/r) o raltegravir (RAL). La probabilidad de lograr la supresión virológica mediante los tratamientos incluidos en el modelo se ha obtenido de ensayos clínicos individuales, SPRING2 y FLAMINGO, y los costes fueron expresados en € (2015). El uso del modelo de la perspectiva del Sistema Nacional de Salud espa-ñol, con un horizonte de vida útil y una tasa de descuento del 3% se, aplicó a coste y efectividad. Resultados: El inicio de tratamiento con DTG/ABC/3TC fue dominante cuando se comparó con el inicio del tratamiento con el resto de compara-dores: frente a TDF/FTC/EFV (-67.210,710 € / AVAC) vs DRV/r FTC/TDF o ABC/3TC (-1,787,341.44 € / AVAC) y vs RAL FTC/TDF o ABC/3TC (-1,005,117.13 € / AVAC). Todos los análisis de sensibilidad realizados demostraron la consistencia de estos hallazgos. Conclusiones: Con las premisas consideradas, el inicio del tratamiento con la combinación a dosis fijas de DTG/ABC/3TC parece ser la opción más rentable para el tratamiento de pacientes infectados con el VIH des-de la perspectiva del Sistema Nacional de Salud español

Published
2017

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