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3,256 results on '"Moreno, Santiago"'

1. Syntropy in complex systems: A complement to Shannon's Entropy

Author

Mendez-Moreno, Santiago

Subjects
Condensed Matter - Statistical Mechanics, Computer Science - Information Theory, Mathematical Physics, Mathematics - Dynamical Systems, 94A17, G.3
Abstract

This study introduces the syntropy function ($S_N$) and expectancy function ($E_N$), derived from the novel function $\phi$, to provide a refined perspective on complexity, extending beyond conventional entropy analysis. $S_N$ is designed to detect localized coherent events, whereas $E_N$ encapsulates expected system behaviors, offering a comprehensive framework for understanding system dynamics. The manuscript explores essential theorems and properties, underscoring their theoretical and practical implications. Future research will further elucidate their roles, particularly in biological signals and dynamic systems, suggesting a deep interplay between order and chaos., Comment: 26 pages, 13 figures

Published
2024

10. Isavuconazole Versus Voriconazole as the First-line Therapy for Solid Organ Transplant Recipients With Invasive Aspergillosis: Comparative Analysis of 2 Multicenter Cohort Studies

Author

Fernández-Ruiz, Mario, Gioia, Francesca, Bodro, Marta, Gutiérrez Martín, Isabel, Sabé, Núria, Rodriguez-Álvarez, Regino, Corbella, Laura, López-Viñau, Teresa, Valerio, Maricela, Illaro, Aitziber, Salto-Alejandre, Sonsoles, Cordero, Elisa, Arnaiz de Las Revillas, Francisco, Fariñas, María Carmen, Muñoz, Patricia, Vidal, Elisa, Carratalà, Jordi, Goikoetxea, Josune, Ramos-Martínez, Antonio, Moreno, Asunción, Martín-Dávila, Pilar, Fortún, Jesús, Aguado, José María, López-Medrano, Francisco, San Juan, Rafael, Linares, Laura, Lladó, Laura, González-Costello, José, Melilli, Edoardo, José Castón, Juan, Álvarez-Uría, Ana, Machado, Marina, Olmedo, María, Filigheddu, Eta, Moreno, Santiago, Cantón, Rafael, Pérez-Ayala, Ana, Calvo, Jorge, María Cifrián, José, Gonzalez-Rico, Claudia, Torre-Cisneros, Julián, del Mar Ras, María, Pérez, Sandra, Mónica López-Soria, Leyre, Linares, Laura, and Fernández-Cruz, Ana

Published
2024
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11. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms

Author

Alaggio, Rita, Amador, Catalina, Anagnostopoulos, Ioannis, Attygalle, Ayoma D, Araujo, Iguaracyra Barreto de Oliveira, Berti, Emilio, Bhagat, Govind, Borges, Anita Maria, Boyer, Daniel, Calaminici, Mariarita, Chadburn, Amy, Chan, John KC, Cheuk, Wah, Chng, Wee-Joo, Choi, John K, Chuang, Shih-Sung, Coupland, Sarah E, Czader, Magdalena, Dave, Sandeep S, de Jong, Daphne, Du, Ming-Qing, Elenitoba-Johnson, Kojo S, Ferry, Judith, Geyer, Julia, Gratzinger, Dita, Guitart, Joan, Gujral, Sumeet, Harris, Marian, Harrison, Christine J, Hartmann, Sylvia, Hochhaus, Andreas, Jansen, Patty M, Karube, Kennosuke, Kempf, Werner, Khoury, Joseph, Kimura, Hiroshi, Klapper, Wolfram, Kovach, Alexandra E, Kumar, Shaji, Lazar, Alexander J, Lazzi, Stefano, Leoncini, Lorenzo, Leung, Nelson, Leventaki, Vasiliki, Li, Xiao-Qiu, Lim, Megan S, Liu, Wei-Ping, Louissaint, Abner, Marcogliese, Andrea, Medeiros, L Jeffrey, Michal, Michael, Miranda, Roberto N, Mitteldorf, Christina, Montes-Moreno, Santiago, Morice, William, Nardi, Valentina, Naresh, Kikkeri N, Natkunam, Yasodha, Ng, Siok-Bian, Oschlies, Ilske, Ott, German, Parrens, Marie, Pulitzer, Melissa, Rajkumar, S Vincent, Rawstron, Andrew C, Rech, Karen, Rosenwald, Andreas, Said, Jonathan, Sarkozy, Clémentine, Sayed, Shahin, Saygin, Caner, Schuh, Anna, Sewell, William, Siebert, Reiner, Sohani, Aliyah R, Tooze, Reuben, Traverse-Glehen, Alexandra, Vega, Francisco, Vergier, Beatrice, Wechalekar, Ashutosh D, Wood, Brent, Xerri, Luc, and Xiao, Wenbin

Subjects
Cancer, Hematologic Neoplasms, Humans, Lymphoma, World Health Organization, Clinical Sciences, Oncology and Carcinogenesis, Immunology
Abstract

We herein present an overview of the upcoming 5th edition of the World Health Organization Classification of Haematolymphoid Tumours focussing on lymphoid neoplasms. Myeloid and histiocytic neoplasms will be presented in a separate accompanying article. Besides listing the entities of the classification, we highlight and explain changes from the revised 4th edition. These include reorganization of entities by a hierarchical system as is adopted throughout the 5th edition of the WHO classification of tumours of all organ systems, modification of nomenclature for some entities, revision of diagnostic criteria or subtypes, deletion of certain entities, and introduction of new entities, as well as inclusion of tumour-like lesions, mesenchymal lesions specific to lymph node and spleen, and germline predisposition syndromes associated with the lymphoid neoplasms.

Published
2022

12. All-cause and AIDS-related mortality among people with HIV across Europe from 2001 to 2020: impact of antiretroviral therapy, tuberculosis and regional differences in a multicentre cohort study

Author

Kraef, Christian, Tusch, Erich, Singh, Sabine, Østergaard, Lars, Fätkenheuer, Gerd, Castagna, Antonella, Moreno, Santiago, Kusejko, Katharina, Szetela, Bartosz, Kuznetsova, Anastasiia, Tomažič, Janez, Ranin, Jovan, Zangerle, Robert, Mansson, Fredrik, Marchetti, Giulia, De Wit, Stéphane, Clarke, Amanda, Gerstoft, Jan, Podlekareva, Daria, Peters, Lars, Reekie, Joanne, and Kirk, Ole

Published
2024
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14. Correction: “The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms” Leukemia. 2022 Jul;36(7):1720–1748

Author

Alaggio, Rita, Amador, Catalina, Anagnostopoulos, Ioannis, Attygalle, Ayoma D., de Oliveira Araujo, Iguaracyra Barreto, Berti, Emilio, Bhagat, Govind, Borges, Anita Maria, Boyer, Daniel, Calaminici, Mariarita, Chadburn, Amy, Chan, John K. C., Cheuk, Wah, Chng, Wee-Joo, Choi, John K., Chuang, Shih-Sung, Coupland, Sarah E., Czader, Magdalena, Dave, Sandeep S., de Jong, Daphne, Di Napoli, Arianna, Du, Ming-Qing, Elenitoba-Johnson, Kojo S., Ferry, Judith, Geyer, Julia, Gratzinger, Dita, Guitart, Joan, Gujral, Sumeet, Harris, Marian, Harrison, Christine J., Hartmann, Sylvia, Hochhaus, Andreas, Jansen, Patty M., Karube, Kennosuke, Kempf, Werner, Khoury, Joseph, Kimura, Hiroshi, Klapper, Wolfram, Kovach, Alexandra E., Kumar, Shaji, Lazar, Alexander J., Lazzi, Stefano, Leoncini, Lorenzo, Leung, Nelson, Leventaki, Vasiliki, Li, Xiao-Qiu, Lim, Megan S., Liu, Wei-Ping, Louissaint, Jr, Abner, Marcogliese, Andrea, Medeiros, L. Jeffrey, Michal, Michael, Miranda, Roberto N., Mitteldorf, Christina, Montes-Moreno, Santiago, Morice, William, Nardi, Valentina, Naresh, Kikkeri N., Natkunam, Yasodha, Ng, Siok-Bian, Oschlies, Ilske, Ott, German, Parrens, Marie, Pulitzer, Melissa, Rajkumar, S. Vincent, Rawstron, Andrew C., Rech, Karen, Rosenwald, Andreas, Said, Jonathan, Sarkozy, Clémentine, Sayed, Shahin, Saygin, Caner, Schuh, Anna, Sewell, William, Siebert, Reiner, Sohani, Aliyah R., Suzuki, Ritsuro, Tooze, Reuben, Traverse-Glehen, Alexandra, Vega, Francisco, Vergier, Beatrice, Wechalekar, Ashutosh D., Wood, Brent, Xerri, Luc, and Xiao, Wenbin

Published
2023
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17. Microbiome-derived cobalamin and succinyl-CoA as biomarkers for improved screening of anal cancer

Author

Serrano-Villar, Sergio, Tincati, Camilla, Raju, Sajan C., Sáenz, Johan S., Moreno, Elena, Bargiela, Rafael, Cabello-Ubeda, Alfonso, Sendagorta, Elena, Kurz, Alina, Perez Molina, Jose A., de Benito, Amparo, Hov, Johannes R., Fernandez-Lopez, Laura, Muriel, Alfonso, del Campo, Rosa, Moreno, Santiago, Trøseid, Marius, Seifert, Jana, and Ferrer, Manuel

Published
2023
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18. Effectiveness and Safety of Direct-acting Antivirals for Treatment of Adolescents With HCV/HIV Coinfection: Real-world Data From Europe

Author

Malik, Farihah, Crichton, Siobhan, Plotnikova, Yulia, Latysheva, Inga, Samarina, Anna, Pokorska-Śpiewak, Maria, Gomez, Marisa Navarro, Bailey, Heather, Thorne, Claire, Judd, Ali, Turkova, Anna, Collins, Intira Jeannie, Marczyńska, Magdalena, Popielska, Jolanta, Ołdakowska, Agnieszka, Zawadka, Konrad, Pluta, Magdalena, Doroba, Małgorzata, Okhonskaya, Liubov, Rozenberg, Vladimir, Voronin, Evgeny, Plynsky, Alexksey A., José Mellado, María, Escosa, Luis, García Hortelano, Milagros, Sainz, Talía, Grasa, Carlos, Rodríguez, Paula, Rojo, Pablo, Prieto-Tato, Luis, Epalza, Cristina, Tagarro, Alfredo, Domínguez, Sara, Ballesteros, Álvaro, Tomás Ramos, José, Illán, Marta, Berzosa, Arantxa, Guillén, Sara, Soto, Beatriz, Luisa Navarro, María, Saavedra, Jesús, Santos, Mar, Aguilera, David, Santiago, Begoña, Jimenez de Ory, Santiago, Bermejo, Amanda, Penín, María, Martínez, Jorge, Badillo, Katie, Belén Jiménez, Ana, Navas, Adriana, Oñate, Eider, Pocheville, Itziar, Garrote, Elisa, Colino, Elena, Afonso, Olga, Gómez Sirvent, Jorge, Garzón, Mónica, Román, Vicente, Angulo, Raquel, Neth, Olaf, Falcón, Lola, Terol, Pedro, Luis Santos, Juan, Vázquez, Álvaro, Carazo, Begoña, Medina, Antonio, Lendínez, Francisco, Ibáñez, Mercedes, Peromingo, Estrella, Isabel Sánchez, María, Ruiz, Beatriz, Grande, Ana, José Romero, Francisco, Pérez, Carlos, Calle, Laura, Pareja, Marta, Losada, Begoña, Herranz, Mercedes, Bustillo, Matilde, Collado, Pilar, Antonio Couceiro, José, Vila, Leticia, Calviño, Consuelo, Isabel Piqueras, Ana, Oltra, Manuel, Gavilán, César, Montesinos, Elena, Dapena, Marta, Jiménez, Beatriz, Gloria Andrés, Ana, Marugán, Víctor, Ochoa, Carlos, Isabel Menasalvas, Ana, Cervantes, Eloísa, Álvarez, Beatriz, Díez, Cristina, Bernardino, Ignacio, Luisa Montes, María, Valencia, Eulalia, Delgado, Ana, Rubio, Rafael, Pulido, Federico, Bisbal, Otilia, Monereo Alonso, Alfonso, Berenguer, Juan, Díez, Cristina, Aldamiz, Teresa, Tejerina, Francisco, Carlos Bernaldo de Quirós, Juan, Padilla, Belén, Carrillo, Raquel, Montilla, Pedro, Bermúdez, Elena, Valerio, Maricela, Sanz, Jose, Gimeno, Alejandra, Cervero, Miguel, Torres, Rafael, Moreno, Santiago, Jesús Perez, María, del Campo, Santos, Ryan, Pablo, Troya, Jesus, Sanz, Jesus, Losa, Juan, Gomez, Rafael, Górgolas, Miguel, Díaz, Alberto, de la Fuente, Sara, Antonio Iribarren, Jose, Jose Aramburu, Maria, Martinez, Lourdes, Josune Goikoetxea, Ane, Ibarra, Sofia, de la Peña, Mireia, Asensi, Víctor, Hernandez, Michele, Remedios Alemán, María, Pelazas, Ricardo, del Mar Alonso, María, María López, Ana, García, Dácil, Rodriguez, Jehovana, Angel Cardenes, Miguel, Castaño, Manuel A., Orihuela, Francisco, Pérez, Inés, Isabel Mayorga, Mª, Fernando Lopez-Cortes, Luis, Roca, Cristina, Llaves, Silvia, Jose Rios, Maria, Rodriguez, Jesus, Palomo, Virginia, Pasquau, Juan, Garcia, Coral, Hernandez, Jose, Martinez, Clara, Rivero, Antonio, Camacho, Angela, Merino, Dolores, Raffo, Miguel, Corpa, Laura, Martinez, Elisa, Mateos, Fernando, Javier Blanch, Jose, Torralba, Miguel, Arazo, Piedad, Samperiz, Gloria, Miralles, Celia, Ocampo, Antonio, Pousada, Guille, Mena, Alvaro, Montero, Marta, Salavert, Miguel, Jose Galindo, Maria, Pretel, Natalia, Portilla, Joaquín, Portilla, Irene, Gutierrez, Felix, Masia, Mar, Robledano, Cati, Adsuar, Araceli, Hinojosa, Carmen, Monteagudo, Begoña, Bachiller, Pablo, Abadía, Jesica, Galera, Carlos, Albendin, Helena, Fernandez, Marian, and Ramon Blanco, Jose

Published
2024
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19. Decalogue to promote the implementation and improvement of recommendations for the early diagnosis of HIV in Emergency Departments

Author

González del Castillo, Juan, Perez Elias, Maria Jesus, Miguens, Iría, Espinosa, Begoña, Juárez, Ricardo, Piedrafita Lozoya, Lourdes, Trenc, Patricia, Alvarez Manzanares, Jesús, Marchena, María José, Rodríguez, Raquel, Cabrera, Nayra, Grajal, Pilar, Navarro, Carmen, Piñera, Pascual, García, Federico, Moreno, Santiago, and Miro, Oscar

Published
2024
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20. Decálogo para promover la implementación y mejora de las recomendaciones para el diagnóstico temprano del VIH en los servicios de urgencias

Author

González del Castillo, Juan, Perez Elias, Maria Jesus, Miguens, Iría, Espinosa, Begoña, Juárez, Ricardo, Piedrafita Lozoya, Lourdes, Trenc, Patricia, Alvarez Manzanares, Jesus, Marchena, María José, Rodríguez, Raquel, Cabrera, Nayra, Grajal, Pilar, Navarro, Carmen, Piñera, Pascual, García, Federico, Moreno, Santiago, and Miro, Oscar

Published
2024
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22. Global DNA methylation and telomere length as markers of accelerated aging in people living with HIV and non-alcoholic fatty liver disease

Author

Moreno, Elena, Martínez-Sanz, Javier, Martín-Mateos, Rosa, Díaz-Álvarez, Jorge, Serrano-Villar, Sergio, Burgos-Santamaría, Diego, Luna, Laura, Vivancos, María Jesús, Moreno-Zamora, Ana, Pérez-Elías, María Jesús, Moreno, Santiago, Dronda, Fernando, Montes, María Luisa, and Sánchez-Conde, Matilde

Published
2023
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24. Anticipating Cyberdefense Capability Requirements by Link Prediction Analysis

Author

Moreno, Santiago Anton, Percia David, Dimitri, Mermoud, Alain, Maillart, Thomas, Mezzetti, Anita, Price, Camille C., Series Editor, Zhu, Joe, Associate Editor, Hillier, Frederick S., Founding Editor, Borgonovo, Emanuele, Editorial Board Member, Nelson, Barry L., Editorial Board Member, Patty, Bruce W., Editorial Board Member, Pinedo, Michael, Editorial Board Member, Vanderbei, Robert J., Editorial Board Member, and Keupp, Marcus Matthias, editor

Published
2023
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25. Tenofovir Disoproxil Fumarate Reduces the Severity of COVID-19 in Patients with Chronic Hepatitis B

Author

Mateos-Muñoz, Beatriz, Buti, María, Vázquez, Inmaculada Fernández, Conde, Marta Hernández, Bernal-Monterde, Vanesa, Díaz-Fontenla, Fernando, Morillas, Rosa María, García-Buey, Luisa, Badía, Ester, Miquel, Mireia, Amador-Navarrete, Alberto, Rodríguez-Tajes, Sergio, Ramos-Merino, Lucía, Madejón, Antonio, García-Retortillo, Montserrat, Arenas, Juan Ignacio, Cabezas, Joaquín, Santiago, Jesús Manuel González, Fernández-Rodríguez, Conrado, Cordero, Patricia, Diago, Moisés, Mancebo, Antonio, Pardo, Alberto, Rodríguez, Manuel, Hoyas, Elena, Moreno, Jose Javier, Turnes, Juan, Simón, Miguel Ángel, Marcos-Fosch, Cristina, Calleja, Jose Luis, Bañares, Rafael, Lens, Sabela, Garcia-Samaniego, Javier, Crespo, Javier, Romero-Gomez, Manuel, Gea, Francisco, de Santiago, Enrique Rodríguez, Moreno, Santiago, and Albillos, Agustin

Published
2023
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27. Author Correction: Microbiome-derived cobalamin and succinyl-CoA as biomarkers for improved screening of anal cancer

Author

Serrano-Villar, Sergio, Tincati, Camilla, Raju, Sajan C., Sáenz, Johan S., Moreno, Elena, Bargiela, Rafael, Cabello-Ubeda, Alfonso, Sendagorta, Elena, Kurz, Alina, Perez Molina, Jose A., de Benito, Amparo, Hov, Johannes R., Fernandez-Lopez, Laura, Muriel, Alfonso, del Campo, Rosa, Moreno, Santiago, Trøseid, Marius, Seifert, Jana, and Ferrer, Manuel

Published
2024
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30. ARID2 deficiency promotes tumor progression and is associated with higher sensitivity to chemotherapy in lung cancer

Author

Moreno, Thaidy, Monterde, Beatriz, González-Silva, Laura, Betancor-Fernández, Isabel, Revilla, Carlos, Agraz-Doblas, Antonio, Freire, Javier, Isidro, Pablo, Quevedo, Laura, Blanco, Rosa, Montes-Moreno, Santiago, Cereceda, Laura, Astudillo, Aurora, Casar, Berta, Crespo, Piero, Morales Torres, Cristina, Scaffidi, Paola, Gómez-Román, Javier, Salido, Eduardo, and Varela, Ignacio

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Lung Cancer, Genetics, Rare Diseases, Lung, Cancer, 2.1 Biological and endogenous factors, Aetiology, A549 Cells, Animals, Cell Line, Tumor, Disease Progression, Female, High-Throughput Nucleotide Sequencing, Humans, Lung Neoplasms, Mice, Mice, Nude, Survival Rate, Transcription Factors, Clinical Sciences, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

The survival rate in lung cancer remains stubbornly low and there is an urgent need for the identification of new therapeutic targets. In the last decade, several members of the SWI/SNF chromatin remodeling complexes have been described altered in different tumor types. Nevertheless, the precise mechanisms of their impact on cancer progression, as well as the application of this knowledge to cancer patient management are largely unknown. In this study, we performed targeted sequencing of a cohort of lung cancer patients on genes involved in chromatin structure. In addition, we studied at the protein level the expression of these genes in cancer samples and performed functional experiments to identify the molecular mechanisms linking alterations of chromatin remodeling genes and tumor development. Remarkably, we found that 20% of lung cancer patients show ARID2 protein loss, partially explained by the presence of ARID2 mutations. In addition, we showed that ARID2 deficiency provokes profound chromatin structural changes altering cell transcriptional programs, which bolsters the proliferative and metastatic potential of the cells both in vitro and in vivo. Moreover, we demonstrated that ARID2 deficiency impairs DNA repair, enhancing the sensitivity of the cells to DNA-damaging agents. Our findings support that ARID2 is a bona fide tumor suppressor gene in lung cancer that may be exploited therapeutically.

Published
2021

34. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events

Author

Jarrín, Inma, Dalmau, David, Navarro, M. Luisa, González, M. Isabel, Garcia, Federico, Poveda, Eva, Iribarren, Jose Antonio, Gutiérrez, Félix, Rubio, Rafael, Vidal, Francesc, Berenguer, Juan, González, Juan, Muñoz-Fernández, M. Ángeles, Jarrín, Inmaculada, Moreno, Cristina, Rava, Marta, Izquierdo, Rebeca, Mauleón, Elba, Portilla, Joaquín, Portilla, Irene, Merino, Esperanza, García, Gema, Agea, Iván, Sánchez-Payá, José, Rodríguez, Juan Carlos, Giner, Livia, Reus, Sergio, Boix, Vicente, Torrus, Diego, Pérez, Verónica, Portilla, Julia, Gómez, Juan Luís, Hernández, Jehovana, Lirola, Ana López, García, Dácil, Díaz-Flores, Felicitas, Alonso, M. Mar, Pelazas, Ricardo, Alemán, M. Remedios, Asensi, Víctor, Rivas Carmenado, María Eugenia, Suarez-Zarracina, Tomás, Pulido, Federico, Bisbal, Otilia, Hernando, M. Asunción, Rial, David, de Lagarde, María, Arce, Octavio, Pinto, Adriana, Bermejo, Laura, Santacreu, Mireia, Navarro, Roser, Gonzalez, Candela, Aramburu, M. José, Camino, Xabier, Ángel von Wichmann, Miguel, Goenaga, Miguel Ángel, Bustinduy, M. Jesús, Azkune, Harkaitz, Ibarguren, Maialen, Kortajarena, Xabier, Álvarez-Rodriguez, Ignacio, Gil, Leire, Martínez, Lourdes, Robledano, Catalina, Masiá, Mar, Padilla, Sergio, Adsuar, Araceli, Pascual, Rafael, Fernández, Marta, Galiana, Antonio, García, José Alberto, Barber, Xavier, Agullo, Vanessa, Abellán, Javier Garcia, Pascual, Reyes, Telenti, Guillermo, Guillén, Lucia, Botella, Ángela, Muga, Roberto, Sanvisens, Arantza, Fuster, Daniel, Gutierrez, Isabel, López, Juan Carlos, Ramírez, Margarita, Padilla, Belén, Gijón, Paloma, Aldamiz-Echevarría, Teresa, Tejerina, Francisco, Diez, Cristina, Pérez, Leire, Fanciulli, Chiara, Corral, Saray, Martí, Anna, Peraire, Joaquín, Viladés, Consuelo, Vargas, Montserrat, Olona, Montserrat, Rull, Anna, Alba, Verónica, Yeregui, Elena, Masip, Jenifer, García-Pardo, Graciano, Bertomeu, Frederic Gómez, Espineira, Sonia, Montero, Marta, Cuéllar, Sandra, Blanes, Marino, Tasias, María, Calabuig, Eva, Salavert, Miguel, Fernández, Juan, Segarra, Inmaculada, González-García, Juan, Delgado, Ana, Arnalich, Francisco, Arribas, José Ramón, Bernardino, Jose Ignacio, Castro, Juan Miguel, Escosa, Luis, Herranz, Pedro, Hontañón, Victor, García-Bujalance, Silvia, García, Milagros, González-Baeza, Alicia, Martín-Carbonero, M. Luz, Mayoral, Mario, Mellado, M. Jose, Esteban, Rafael, Montejano, Rocío, Montes, M. Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rodés, Berta, Rúa, Guadalupe, Sainz, Talía, Sendagorta, Elena, Valencia, Eulalia, Busca, Carmen, Cano, Joanna, Cardiñanos, Julen, de Miguel, Rosa, Blanco, Jose Ramón, Pérez-Martínez, Laura, Oteo, José Antonio, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Arazo, Piedad, Sampériz, Gloria, Martinez, Marina, Jaén, Angels, Sanmartí, Montse, Cairó, Mireia, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, Mariona, Alonso, Noemí, Aiello, Francesco, Rivero, María, Piérola, Beatriz, Goikoetxea, Maider, Gracia, María, Ibero, Carlos, Moreno, Estela, Repáraz, Jesús, Navarro, Gemma, Garcia, Manel Cervantes, Isbert, Sonia Calzado, Vilasaro, Marta Navarro, Garcia, Belen Lopez, Santos, Ignacio de los, Santos, Alejandro de los, Sanz, Jesús, García-Fraile, Lucio, Martín, Enrique, Sánchez-Cerrillo, Ildefonso, Calvet, Marta, Barrios, Ana, Bautista, Azucena, Sáez, Carmen, Ciudad, Marianela, Gutiérrez, Ángela, Moreno, Santiago, Campo, Santos del, Casado, José Luis, Dronda, Fernando, Moreno, Ana, Pérez, M. Jesús, Serrano, Sergio, Vivancos, M<ce:sup loc='post">a</ce:sup> Jesús, Martínez-Sanz, Javier, Vallejo, Alejandro, Sanchez, Matilde, Pérez-Molina, Jose Antonio, Hermida, José Manuel, Bernal, Enrique, Alcaraz, Antonia, Bravo, Joaquín, Muñoz, Ángeles, Tomás, Cristina, Martínez, Mónica, Villalba, M. Carmen, García, Federico, Martínez, Clara, Hernández, José, Medina, Leopoldo Muñoz, Álvarez, Marta, Chueca, Natalia, Vinuesa, David, de Salazar, Adolfo, Fuentes, Ana, Guirao, Emilio, Viñuela, Laura, Ruiz-Sancho, Andrés, Anguita, Francisco, Del Romero, Jorge, Raposo, Montserrat, Rodríguez, Carmen, Puerta, Teresa, Carrió, Juan Carlos, Vera, Mar, Ballesteros, Juan, Ayerdi, Oskar, Baza, Begoña, Orviz, Eva, Antela, Antonio, Losada, Elena, Riera, Melchor, Peñaranda, María, Ribas, M. Angels, Campins, Antoni A., Garcia-Gazalla, Mercedes, Fanjul, Francisco J., Murillas, Javier, Homar, Francisco, Vilchez, Helem H., Martin, Luisa, Payeras, Antoni, Santos, Jesús, López, María, Gómez, Crisitina, Viciana, Isabel, Palacios, Rosario, López-Cortés, Luis Fernando, Espinosa, Nuria, Roca, Cristina, Llaves, Silvia, Tiraboschi, Juan Manuel, Imaz, Arkaitz, Silva, Ana Karina, Saumoy, María, Scévola, Sofía Catalina, Curran, Adrián, Falcó, Vicenç, Navarro, Jordi, Burgos, Joaquin, Suanzes, Paula, García, Jorge, Descalzo, Vicente, Álvarez, Patricia, Planas, Bibiana, Sanchiz, Marta, Rodríguez, Lucía, Olalla, Julián, Sánchez, M José, Pérez, Javier, Arco, Alfonso del, Torre, Javier de la, Prada, José Luis, Martínez, Onofre Juan, Martinez, Lorena, Vera, Francisco Jesús, García, Josefina, Alcaraz, Begoña, Sánchez Guirao, Antonio Jesús, Mena, Alvaro, Castro, Angeles, Pernas, Berta, Vázquez, Pilar, López, Soledad, Ibarra, Sofía, García, Guillermo, Mirena, Josu, Ferrero, Oscar Luis, López, Josefina, Cámara, M. Mar, Peña, Mireia de la, Lopez, Miriam, Lopez, Iñigo, Lombide, Itxaso, Polo, Victor, de Miguel, Joana, Galera, Carlos, Fernández, Marian, Albendin, Helena, Castillo, Antonia, Iborra, Asunción, Moreno, Antonio, Merlos, M. Angustias, Vidal, Asunción, Amador, Concha, Pasquau, Francisco, Gil, Concepcion, Algado, Jose Tomás, Suarez-García, Inés, Malmierca, Eduardo, González-Ruano, Patricia, Ruiz, M. Pilar, Pascual, José Francisco, Sáez, Elena, Balsalobre, Luz, López, M. Villa, Omar, Mohamed, Herrero, Carmen, Gómez, M. Amparo, Alberto de Zarraga, Miguel, Pérez, Desiré, Estrada, Vicente, Sanz, Nieves, Cabello, Noemí, García, Jorge Vergas, Núñez, Maria Jose, Sagastagoitia, Iñigo, Górgolas, Miguel, Cabello, Alfonso, Álvarez, Beatriz, Prieto, Laura, Carrillo, Irene, Sanz, José, Arranz, Alberto, Hernández, Cristina, Novella, María, Galindo, M. José, Ferrer, Ana, Román, Antonio Rivero, Ruíz, Inma, Juárez, Antonio Rivero, López, Pedro, Machuca, Isabel, Frias, Mario, Camacho, Ángela, Pérez, Ignacio, Corona, Diana, Cervero, Miguel, Torres, Rafael, Pineda, Juan Antonio, Rincón, Pilar, Macías, Juan, Real, Luis Miguel, Corma, Anais, Gonzalez-Serna, Alejandro, Pérez, Alexandre, Morano, Luis, Miralles, Celia, Ocampo, Antonio, Pousada, Guillermo, Patiño, Lucía, Dueñas, Carlos, Gutiérrez, Sara, Tapia, Elena, Novoa, Cristina, Egües, Xjoylin, Telleria, Pablo, Díaz-Álvarez, Jorge, Rosas Cancio-Suarez, Marta, Ron, Raquel, Iribarren, José Antonio, Ruiz Sancho, Andrés, Cabello, Noemi, and Serrano-Villar, Sergio

Published
2023
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37. Impact of first-line antiretroviral therapy regimens on the restoration of the CD4/CD8 ratio in the CNICS cohort

Author

Herrera, Sabina, Fernandez-Felix, Borja M, Hunt, Peter W, Deeks, Steven G, Sainz, Talía, Heath, Sonya L, Achenbach, Chad J, Rodríguez, Benigno, Mathews, Christopher, Christopoulos, Katerina, Mayer, Kenneth, Napravnik, Sonia, Moreno, Santiago, and Serrano-Villar, Sergio

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Immunology, HIV/AIDS, Infectious Diseases, Clinical Research, Sexually Transmitted Infections, Clinical Trials and Supportive Activities, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Infection, Good Health and Well Being, Adult, Anti-HIV Agents, CD4-CD8 Ratio, CD8-Positive T-Lymphocytes, Cohort Studies, HIV Infections, Humans, Viral Load, Microbiology, Pharmacology and Pharmaceutical Sciences, Clinical sciences, Pharmacology and pharmaceutical sciences
Abstract

BackgroundThe CD4/CD8 ratio is an indicator of immunosenescence and a predictor of all-cause mortality in HIV-infected patients. The effects of different ART regimens on CD4/CD8 ratio recovery remain unclear.MethodsClinical cohort study of ART-treated patients from the CFAR Network of Integrated Clinical Systems (CNICS). We included ART-naive adults with HIV infection who achieved undetectable HIV RNA during the first 48 weeks of treatment and had additional follow-up 48 weeks after virological suppression (VS). Primary endpoints included increase in CD4/CD8 ratio at both timepoints and secondary endpoints were CD4/CD8 ratio recovery at cut-offs of ≥0.5 or ≥1.0.ResultsOf 3971 subjects who met the study criteria, 1876 started ART with an NNRTI, 1804 with a PI and 291 with an integrase strand transfer inhibitor (INSTI). After adjusting for age, sex, race, year of entry, risk group, HCV serostatus, baseline viral load and baseline CD4/CD8 ratio, subjects on an NNRTI showed a significantly greater CD4/CD8 ratio gain compared with those on a PI, either 48 weeks after ART initiation or after 48 weeks of HIV RNA VS. The greater CD4/CD8 ratio improvement in the NNRTI arm was driven by a higher decline in CD8 counts. The INSTI group showed increased rates of CD4/CD8 ratio normalization at the ≥1.0 cut-off compared with the PI group.ConclusionsNNRTI therapy was associated with a greater increase in the CD4/CD8 ratio compared with PIs. NNRTI- and INSTI-based first-line ART were associated with higher rates of CD4/CD8 ratio normalization at a cut-off of 1.0 than a PI-based regimen, which might have clinical implications.

Published
2020

38. Delayed gastrointestinal-associated lymphoid tissue reconstitution in duodenum compared with rectum in HIV-infected patients initiating antiretroviral therapy.

Author

Sainz, Talia, Serrano-Villar, Sergio, Mann, Surinder, Ma, Zhong-Min, Utay, Netanya S, Thompson, Corbin G, Chun, Tae-Wook, Kashuba, Angela D, Siewe, Basile, Albanese, Anthony, Troia-Cancio, Paolo, Sinclair, Elizabeth, Somasunderam, Anoma, Yotter, Tammy, Moreno, Santiago, Pollard, Richard B, Landay, Alan, Miller, Christopher J, and Asmuth, David M

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Clinical Research, HIV/AIDS, Infectious Diseases, Sexually Transmitted Infections, Digestive Diseases, Infection, Adult, Antiretroviral Therapy, Highly Active, Biopsy, Blood, CD4-CD8 Ratio, CD4-Positive T-Lymphocytes, Duodenum, Female, HIV Infections, Humans, Immune Reconstitution, Immunophenotyping, Intestinal Mucosa, Linear Models, Lymphocyte Activation, Male, Rectum, duodenum, gastrointestinal-associated lymphoid tissue, HIV, immune reconstitution, lipoteichoic acid, rectum, small intestines, T regulatory cells, zonulin, gamma delta intestinal T cells, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Virology, Biomedical and clinical sciences, Health sciences
Abstract

BACKGROUND:We aimed to characterize the impact of ART initiation on GALT at various sites along the gastrointestinal site. METHODOLOGY:Peripheral blood and duodenal and rectal biopsies were obtained from 12 HIV and 33 treatment-naïve HIV subjects at baseline and after 9-months ART. Tissue was digested for immunophenotyping. Inflammatory, bacterial translocation and intestinal damage markers were measured in plasma. RESULTS:Twenty-six HIV subjects completed follow-up. The lowest reconstitution of CD4 T-cells and the lowest CD4/CD8 ratio during ART compared to blood were observed in the duodenum with the rectum being either intermediate or approaching blood levels. Regulatory T-cells (Treg) were in higher proportions in the duodenum than the rectum and neither declined significantly during ART. Several correlations with biomarkers of microbial translocation were observed including increases in LTA levels, which reflects gram-positive bacterial translocation, correlated with increases in %CD4 T-cells in duodenum (Rho 0.773, P = 0.033), and with decreases duodenal Treg populations (Rho -0.40, P = 0.045). CONCLUSIONS:HIV-mediated immunological disruption is greater in the duodenum than rectum and blood before and during ART. Small intestine damage may represent a unique environment for T-cell depletion, which might be attenuated by interaction with gram positive bacteria.

Published
2019

39. Daily tenofovir disoproxil fumarate/emtricitabine and hydroxychloroquine for pre-exposure prophylaxis of COVID-19: a double-blind placebo-controlled randomized trial in healthcare workers

Author

Julia del Amo, Polo, Rosa, Moreno, Santiago, Berenguer, Juan, Martínez, Esteban, Hernán, Miguel, Martínez de Salazar, Pablo, García de Albéniz, Xabier, García-Albéniz, Xabier, Terán, Carolina, Morales, Miguel, Rial-Crestelo, David, Garcinuño, M. Angeles, García del Toro, Miguel, Hita, César, Gómez-Sirvent, Juan Luis, Buzón, Luis, Díaz de Santiago, Alberto, Arellano, Jose Pérez, Sanz, Jesus, Bachiller, Pablo, Alfaro, Elisa Martínez, Díaz-Brito, Vicente, Masiá, Mar, Hernández-Torres, Alicia, Guerra, Jose M., Santos, Jesús, Arazo, Piedad, Muñoz, Leopoldo, Arribas, Jose Ramon, Hernán, Miguel A., and Del Amo, Julia

Published
2023
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41. Fecal Microbiota Transplantation Alters the Proteomic Landscape of Inflammation in HIV: Identifying Bacterial Drivers

Author

Díaz-García, Claudio, primary, Moreno, Elena, additional, Talavera, Alba, additional, Martín-Fernández, Lucía, additional, Martín-Pedraza, Laura, additional, Pérez-Molina, José A., additional, González-Bodí, Sara, additional, Huerta-Cepas, Jaime, additional, Dronda, Fernando, additional, Gosalbes, María José, additional, Luna, Laura, additional, Vivancos, María Jesús, additional, Moreno, Santiago, additional, and Serrano-Villar, Sergio, additional

Published
2024
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43. Osteomesopyknosis associated with a novel ALOX5 variant that impacts the RANKL pathway

Author

Fernandez‐Luna, Jose L., primary, Hernández, José L., additional, Curiel‐Olmo, Soraya, additional, Martínez‐Amador, Néstor A., additional, Vega, Ana I., additional, Quirce, Remedios, additional, Montes‐Moreno, Santiago, additional, Gutierrez, Olga, additional, del Real, Alvaro, additional, Sañudo, Carolina, additional, and Riancho, Jose A., additional

Published
2024
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50. GECOP-MMC: phase IV randomized clinical trial to evaluate the efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC) with mytomicin-C after complete surgical cytoreduction in patients with colon cancer peritoneal metastases

Author

Pereira, Fernando, Serrano, Angel, Manzanedo, Israel, Pérez-Viejo, Estibalitz, González-Moreno, Santiago, González-Bayón, Luis, Arjona-Sánchez, Alvaro, Torres, Juan, Ramos, Isabel, Barrios, Maria E., Cascales, Pedro, Morales, Rafael, Boldó, Enrique, García-Fadrique, Alfonso, Arteaga, Xabier, Gutierrez-Calvo, Alberto, Sánchez-García, Susana, Asensio, Enrique, Ramírez, Cesar P., Artiles, Manuel, Vaqué, Javier, Parra, Pedro A., Villarejo, Pedro, Muñoz-Casares, Cristóbal, Turienzo, Estrella, Calero, Alicia, Torrejimeno, Isabel Jaén, Prieto, Isabel, Galindo, Julio, Borrego, Vicente, Marcello, Manuel E., Rihuete, Cristina, Carrasco, Joaquin, and Gomez-Quiles, Luis

Published
2022
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