1. Evaluation of IL-35, as a Possible Biomarker for Follow-Up after Therapy, in Chronic Human Schistosoma Infection
- Author
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Nadia Marascio, Maria Teresa Loria, Grazia Pavia, Cinzia Peronace, Neill James Adams, Morena Campolo, Francesca Divenuto, Angelo Giuseppe Lamberti, Aida Giancotti, Giorgio Settimo Barreca, Maria Mazzitelli, Enrico Maria Trecarichi, Carlo Torti, Francesca Perandin, Zeno Bisoffi, Angela Quirino, and Giovanni Matera
- Subjects
Schistosoma haematobium ,Schistosoma mansoni ,IL-35 ,Medicine - Abstract
The host response to helminth infections is characterized by systemic and tissue-related immune responses that play a crucial role in pathological diseases. Recently, experimental studies have highlighted the role of regulatory T (Tregs) and B (Bregs) cells with secreted cytokines as important markers in anti-schistosomiasis immunity. We investigated the serical levels of five cytokines (TNFα, IFN-γ, IL-4, IL-10 and IL-35) in pre- and post-treatment samples from chronic Schistosoma infected patients to identify potential serological markers during follow-up therapy. Interestingly, we highlighted an increased serum level of IL-35 in the pre-therapy samples (median 439 pg/mL for Schistosoma haematobium and 100.5 pg/mL for Schistsoma mansoni infected patients) compared to a control group (median 62 pg/mL and 58 pg/mL, respectively, p ≤ 0.05), and a significantly lower concentration in post-therapy samples (181 pg/mL for S. haematobium and 49.5 pg/mL for S. mansoni infected patients, p ≤ 0.05). The present study suggests the possible role of IL-35 as a novel serological biomarker in the evaluation of Schistosoma therapy follow-up.
- Published
- 2023
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