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636 results on '"Morelli I"'

4. Pattern of Recurrence After Stereotactic Radiotherapy in Prostate Cancer Patients With Nodal Pelvic Relapse. A Multi-Institutional Retrospective Analysis

Author

Francolini, G., Bellini, C., Di Cataldo, V., Detti, B., Bruni, A., Alicino, G., Triggiani, L., La Mattina, S., D'Angelillo, R.M., Demofonti, C., Mazzola, R., Cuccia, F., Alongi, F., Aquilano, M., Allegra, A.G., Ciccone, L.P., Burchini, L., Salvestrini, V., Morelli, I., Frosini, G., Desideri, I., and Livi, L.

Published
2022
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5. The Role of Stereotactic Radiotherapy in Deferring the Need for Systemic Therapies in Patients with Progressive Oligometastatic Iodine-Refractory Thyroid Cancer

Author

Simontacchi, G., primary, Sparano, C., additional, Loi, M., additional, Mangoni, M., additional, Olmetto, E., additional, Garlatti, P., additional, Scoccimarro, E., additional, Frosini, G., additional, Bertini, N., additional, Morelli, I., additional, Romei, A., additional, Orsatti, C., additional, Pallotta, S., additional, Calusi, S., additional, Cataldo, V. Di, additional, and Livi, L., additional

Published
2023
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6. Long Term Clinical Outcomes of a Cohort of Lung-Only Oligometastatic HNSCC Patients Treated with SBRT

Author

Salvestrini, V., primary, Becherini, C., additional, Desideri, I., additional, Simontacchi, G., additional, Loi, M., additional, Garlatti, P., additional, Bertini, N., additional, Bonaparte, I., additional, Mattioli, C., additional, Banini, M., additional, Morelli, I., additional, Meattini, I., additional, Bonomo, P., additional, and Livi, L., additional

Published
2023
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7. Clinical Outcomes and Dosimetric Predictive Factors in Patients Undergoing Reirradiation for Recurrent Meningiomas

Author

Desideri, I., primary, Scartoni, D., additional, Morelli, I., additional, Banini, M., additional, Visani, L., additional, Greto, D., additional, Detti, B., additional, Perini, Z., additional, Zivelonghi, E., additional, Bulgarelli, G., additional, Pinzi, V., additional, Pierina, N., additional, Clerici, E., additional, Ascolese, A.M., additional, Anselmo, P., additional, Amelio, D., additional, Osti, M.F., additional, Minniti, G., additional, and Livi, L., additional

Published
2023
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9. PD-0576 Stereotactic reirradiation for locally recurrent prostate cancer after definitive radiotherapy

Author

Francolini, G., primary, Cerbai, C., additional, Carnevale, M.G., additional, Di Cataldo, V., additional, Detti, B., additional, Loi, M., additional, Frosini, G., additional, Guerrieri, B., additional, Morelli, I., additional, Roghi, M., additional, Ganovelli, M., additional, Allegra, A., additional, Salvestrini, V., additional, Visani, L., additional, Olmetto, E., additional, Greto, D., additional, Simontacchi, G., additional, Mangoni, M., additional, Desideri, I., additional, Meattini, I., additional, and Livi, L., additional

Published
2023
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11. PO-1391 Dose intensification in Locally Advanced Pancreatic Cancer using Robotic SBRT

Author

valzano, M., primary, Loi, M., additional, Bonomo, P., additional, Masi, L., additional, Doro, R., additional, Salvestrini, V., additional, Banini, M., additional, Lorenzetti, V., additional, Morelli, I., additional, Romei, A., additional, Di Cataldo, V., additional, Francolini, G., additional, Greto, D., additional, Mangoni, M., additional, Simontacchi, G., additional, and Livi, L., additional

Published
2023
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12. PD-0652 Re-irradiation of recurrent intracranial meningiomas: an Italian multicenter retrospective study

Author

Desideri, I., primary, Morelli, I., additional, Visani, L., additional, Greto, D., additional, Detti, B., additional, Perini, Z., additional, Zivelonghi, E., additional, Bulgarelli, G., additional, Pinzi, V., additional, Navarria, P., additional, Clerici, E., additional, Ascolese, A.M., additional, Anselmo, P., additional, Amelio, D., additional, Osti, M.F., additional, Minniti, G., additional, Livi, L., additional, and Scartoni, D., additional

Published
2023
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17. PD-0849 Concomitant Nivolumab and RT in metastatic kidney cancer. Benefit of ablative vs palliative approach

Author

Francolini, G., primary, Di Cataldo, V., additional, Detti, B., additional, Loi, M., additional, Ghirardelli, P., additional, Vavassori, V., additional, Nicosia, L., additional, Alongi, F., additional, Triggiani, L., additional, La Mattina, S., additional, Allegra, A.G., additional, Scoccimarro, E., additional, Aquilano, M., additional, Lucidi, S., additional, Valzano, M., additional, Peruzzi, A., additional, Morelli, I., additional, Mariotti, M., additional, Salvestrini, V., additional, Stocchi, G., additional, Ciccone, L.P., additional, Desideri, I., additional, and Livi, L., additional

Published
2021
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20. Extracts and constituents of Lavandula multifida with topical anti-inflammatory activity

Author

Sosa, S., Altinier, G., Politi, M., Braca, A., Morelli, I., and Loggia, R. Della

Subjects
Lavenders -- Research, Anti-inflammatory drugs -- Research, Biological sciences, Health, Science and technology
Abstract

Abstract The topical anti-inflammatory activity of the ethanol and aqueous extracts from the aerial parts of Lavandula multifida L. (Lamiaceae), used in the Moroccan traditional medicine, was investigated by inhibition [...]

Published
2005

21. Topical anti-inflammatory activity of Bauhinia tarapotensis leaves

Author

Sosa, S., Braca, A., Altinier, G., Loggia, R. Della, Morelli, I., and Tubaro, A.

Subjects
Biological sciences, Health, Science and technology
Abstract

Summary The topical anti-inflammatory properties of Bauhinia tarapotensis Benth. (Leguminosae) leaves have been studied by the inhibition of the croton oil-induced ear edema in mice. A bioassay-guided fractionation showed an [...]

Published
2002

23. The World Association against Infection in Orthopaedics and Trauma (WAIOT) procedures for Microbiological Sampling and Processing for Periprosthetic Joint Infections (PJIs) and other Implant-Related Infections

Author

Drago, L, Clerici, P, Morelli, I, Ashok, J, Benzakour, T, Bozhkova, S, Alizadeh, C, del Sel, H, Sharma, HK, Peel, T, Mattina, R, Romano, CL, Drago, L, Clerici, P, Morelli, I, Ashok, J, Benzakour, T, Bozhkova, S, Alizadeh, C, del Sel, H, Sharma, HK, Peel, T, Mattina, R, and Romano, CL

Abstract

While implant-related infections continue to play a relevant role in failure of implantable biomaterials in orthopaedic and trauma there is a lack of standardised microbiological procedures to identify the pathogen(s). The microbiological diagnosis of implant-related infections is challenging due to the following factors: the presence of bacterial biofilm(s), often associated with slow-growing microorganisms, low bacterial loads, previous antibiotic treatments and, possible intra-operative contamination. Therefore, diagnosis requires a specific set of procedures. Based on the Guidelines of the Italian Association of the Clinical Microbiologists (AMCLI), the World Association against Infection in Orthopaedics and Trauma has drafted the present document. This document includes guidance on the basic principles for sampling and processing for implant-related infections based on the most relevant literature. These procedures outline the main microbiological approaches, including sampling and processing methodologies for diagnostic assessment and confirmation of implant-related infections. Biofilm dislodgement techniques, incubation time and the role of molecular approaches are addressed in specific sections. The aim of this paper is to ensure a standardised approach to the main microbiological methods for implant-related infections, as well as to promote multidisciplinary collaboration between clinicians and microbiologists.

Published
2019

36. Neutrophil gelatinase-associated lipocalin (NGAL): a promising biomarker for the early diagnosis of acute kidney injury (AKI)

Author

Antonucci, E., Lippi, G., Andrea Ticinesi, Pigna, F., Guida, L., Morelli, I., Nouvenne, A., Borghi, L., and Meschi, T.

Subjects
Early Diagnosis, Lipocalin-2, Predictive Value of Tests, Acute Kidney Injury, cardiac surgery, NGAL, Humans, Biomarkers
Abstract

Acute kidney injury (AKI) is a common complication that occurs in a broad spectrum of clinical settings. Cardiac surgery-associated AKI continues to be a well-recognized complication of cardiac surgery with high morbidity and mortality. The lack of early biomarkers has for long prevented timely interventions to mitigate the effects of AKI. Serum creatinine is not a timely marker of AKI, so that it cannot be used to set potentially effective therapies to treat AKI in patients during phases when the injury is still potentially reversible. Neutrophil gelatinase-associated lipocalin (NGAL) has been identified as a promising biomarker for early detection of AKI. Several studies have shown that NGAL levels significantly increase in AKI patients 24 to 48 hours before a detectable increase of serum creatinine. Recent studies also suggest that measurements of urinary NGAL levels in patients at risk for cardiac surgery-associated AKI may facilitate its early diagnosis and allow clinicians to implement therapeutic adjustments that have the potential to reverse renal cellular damage and minimize further kidney injury.

Published
2014

39. Citotoxic Saponins from Schefflera rotundifolia

Author

Braca, A., Autore, G., DE SIMONE, F., Marzocco, S., Morelli, I., Venturella, F., BRACA, A, AUTORE, G, DE SIMONE, F, MARZOCCO, S, MORELLI, I, and VENTURELLA, F

Abstract

Eight new oleanane and lupane saponins (1-8) as well as two new benzyl glycosides (9 and 10) were isolated from the aerial parts of Schefflera rotundifolia (Ten) Frodin (Araliaceae) together with two known benzyl glycosides. Their structures were established using 1D- and 2D-NMR spectroscopy and mass spectrometry. The antiproliferative activity of all compounds was evaluated using three continuous murine and human culture cell lines J774.A1, HEK-293, and WEHI-164. Compounds 7 and 8, having betulinic acid as aglycone, were the most active constituents

Published
2004

40. Citotoxic saponins from Schefflera fagueti

Author

Cioffi, G., Braca, A., Autore, G., Morelli, I., Pinto, A., Venturella, F., De Tommasi, N., Cioffi, G, Braca, A, Autore, G, Morelli, I, Pinto, A, Venturella, F, and De Tommasi, N

Subjects
Settore BIO/14 - Farmacologia, Triterpene saponins, Antiproliferative activity
Published
2003

41. Insights into the mechanisms of desiccation resistance of the Patagonian PAH‐degrading strain <italic>Sphingobium</italic> sp. 22B.

Author

Madueño, L., Coppotelli, B. M., Festa, S., Alvarez, H. M., and Morelli, I. S.

Subjects
TREHALOSE, GLYCOGEN, POLYHYDROXYBUTYRATE, TRANSMISSION electron microscopy, SPHINGOMONAS
Abstract

Abstract: Aim: To analyse the physiological response of Sphingobium sp. 22B to water stress. Methods and Results: The strain was grown under excess of carbon source and then subjected to low (60RH) and high (18RH) water stress conditions for 96 h. Quantification of trehalose, glycogen, polyhydroxybutyrate (PHB) and transmission electron microscopy (TEM) was studied. Genes linked with desiccation were searched in Sphingobium sp. 22B and Sphingomonas ‘sensu latu’ genomes and their transcripts were quantified by real‐time PCR. Results showed that, in the absence of water stress, strain 22B accumulated 4·76 ± 1·41% of glycogen, 0·84 ± 1·62% of trehalose and 44·9 ± 6·4% of PHB per cellular dry weight. Glycogen and trehalose were mobilized under water stressed conditions, this mobilization was significantly higher in 60RH in comparison to 18RH. Gene treY was upregulated sixfold in 60RH relative to control condition. TEM and quantification of PHB revealed that PHB was mobilized under 60RH condition accompanied by the downregulation of the phbB gene. TEM images showed an extracellular amorphous matrix in 18RH and 60RH. Major differences were found in the presence of aqpZ and trehalose genes between strain 22B and Sphingomonas genomes. Conclusion: Strain 22B showed a carbon conservative metabolism capable of accumulation of three types of endogenous carbon sources. The strain responds to water stress by changing the expression pattern of genes related to desiccation, formation of an extracellular amorphous matrix and mobilization of the carbon sources according to the degree of water stress. Trehalose, glycogen and PHB may have multiple functions in different degrees of desiccation. The robust endowment of molecular responses to desiccation shown in Sphingobium sp. 22B could explain its survival in semi‐arid soil. Significance and Impact of the Study: Understanding the physiology implicated in the toleration of the PAH‐degrading strain Sphingobium sp 22B to environmental desiccation may improve the bioaugmentation technologies in semi‐arid hydrocarbon‐contaminated soils. [ABSTRACT FROM AUTHOR]

Published
2018
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