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6. Diagnostic performance of cerebroplacental and umbilicocerebral ratio in appropriate for gestational age and late growth restricted fetuses attempting vaginal delivery: a multicenter, retrospective study.

Author

Villalain, Cecilia, Galindo, Alberto, Di Mascio, Daniele, Buca, Danilo, Morales-Rosello, Jose, Loscalzo, Gabriela, Sileo, Filomena Giulia, Finarelli, Alessandra, Bertucci, Emma, Facchinetti, Fabio, Rizzo, Giuseppe, Brunelli, Roberto, Giancotti, Antonella, Muzii, Ludovico, Maruotti, Giuseppe Maria, Carbone, Luigi, D’Amico, Alice, Tinari, Sara, Morelli, Roberta, and Cerra, Chiara

Subjects
DELIVERY (Obstetrics), GESTATIONAL age, FETAL development, PLACENTAL growth factor, NEONATAL intensive care units, FETAL growth retardation
Abstract

Background Cerebroplacental Doppler studies have been advocated to predict the risk of adverse perinatal outcome (APO) irrespective of fetal weight. Objective To report the diagnostic performance of cerebroplacental (CPR) and umbilicocerebral (UCR) ratios in predicting APO in appropriate for gestational age (AGA) fetuses and in those affected by late fetal growth restriction (FGR) attempting vaginal delivery. Study design Multicenter, retrospective, nested case-control study between 1 January 2017 and January 2020 involving five referral centers in Italy and Spain. Singleton gestations with a scan between 36 and 40 weeks and within two weeks of attempting vaginal delivery were included. Fetal arterial Doppler and biometry were collected. The AGA group was defined as fetuses with an estimated fetal weight and abdominal circumference >10th and <90th percentile, while the late FGR group was defined by Delphi consensus criteria. The primary outcome was the prediction of a composite of perinatal adverse outcomes including either intrauterine death, Apgar score at 5 min <7, abnormal acid-base status (umbilical artery pH < 7.1 or base excess of more than −11) and neonatal intensive care unit (NICU) admission. Area under the curve (AUC) analysis was performed. Results 646 pregnancies (317 in the AGA group and 329 in the late FGR group) were included. APO were present in 12.6% AGA and 24.3% late FGR pregnancies, with an odds ratio of 2.22 (95% CI 1.46–3.37). The performance of CPR and UCR for predicting APO was poor in both AGA [AUC: 0.44 (0.39–0.51)] and late FGR fetuses [AUC: 0.56 (0.49–0.61)]. Conclusions CPR and UCR on their own are poor prognostic predictors of APO irrespective of fetal weight. [ABSTRACT FROM AUTHOR]

Published
2022
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7. Diagnostic performance of cerebroplacental and umbilicocerebral ratio in appropriate for gestational age and late growth restricted fetuses attempting vaginal delivery: a multicenter, retrospective study

Author

Villalain, Cecilia, primary, Galindo, Alberto, additional, Di Mascio, Daniele, additional, Buca, Danilo, additional, Morales-Rosello, Jose, additional, Loscalzo, Gabriela, additional, Giulia Sileo, Filomena, additional, Finarelli, Alessandra, additional, Bertucci, Emma, additional, Facchinetti, Fabio, additional, Rizzo, Giuseppe, additional, Brunelli, Roberto, additional, Giancotti, Antonella, additional, Muzii, Ludovico, additional, Maria Maruotti, Giuseppe, additional, Carbone, Luigi, additional, D’Amico, Alice, additional, Tinari, Sara, additional, Morelli, Roberta, additional, Cerra, Chiara, additional, Nappi, Luigi, additional, Greco, Pantaleo, additional, Liberati, Marco, additional, D’Antonio, Francesco, additional, and Herraiz, Ignacio, additional

Published
2021
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9. Comparison between Cerebroplacental Ratio and Umbilicocerebral Ratio in Predicting Adverse Perinatal Outcome in Pregnancies Complicated by Late Fetal Growth Restriction: A Multicenter, Retrospective Study

Author

Di Mascio, Daniele, primary, Herraiz, Ignacio, additional, Villalain, Cecilia, additional, Buca, Danilo, additional, Morales-Rossello, Jose, additional, Loscalzo, Gabriela, additional, Sileo, Filomena Giulia, additional, Finarelli, Alessandra, additional, Bertucci, Emma, additional, Facchinetti, Fabio, additional, Rizzo, Giuseppe, additional, Brunelli, Roberto, additional, Giancotti, Antonella, additional, Muzii, Ludovico, additional, Maruotti, Giuseppe Maria, additional, Carbone, Luigi, additional, D’Amico, Alice, additional, Tinari, Sara, additional, Morelli, Roberta, additional, Cerra, Chiara, additional, Nappi, Luigi, additional, Greco, Pantaleo, additional, Liberati, Marco, additional, Galindo, Alberto, additional, and D’Antonio, Francesco, additional

Published
2021
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10. Effects of a Synbiotic Formula on Functional Bowel Disorders and Gut Microbiota Profile during Long-Term Home Enteral Nutrition (LTHEN): A Pilot Study

Author

D’Onofrio, Valentina, primary, Del Chierico, Federica, additional, Belci, Paola, additional, Vernocchi, Pamela, additional, Quagliariello, Andrea, additional, Reddel, Sofia, additional, Conta, Giorgia, additional, Mancino, Maria Vittoria, additional, Fadda, Maurizio, additional, Scigliano, Maria Carmine, additional, Morelli, Roberta, additional, De Francesco, Antonella, additional, Guagnini, Fabio, additional, Fassio, Filippo, additional, Galletti, Rosalba, additional, and Putignani, Lorenza, additional

Published
2020
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13. L’habitant et la fabrication énergétique des écoquartiers. Processus, conception, réception

Author

Grudet, Isabelle, Heland, Laure, Decup-Pannier, Benoîte, Roudil, Nadine, Morelli, Roberta, Laboratoire Espaces Travail (LET), Ecole d'architecture de Paris-La Villette-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Laboratoire Architecture, Ville, Urbanisme, Environnement (LAVUE), École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV)-École nationale supérieure d'architecture de Paris Val-de-Seine (ENSA PVDS)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Ministère de la Culture (MC)-Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS)-École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV)-École nationale supérieure d'architecture de Paris Val-de-Seine (ENSA PVDS)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Ministère de la Culture (MC)-Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Architecture, Ville, Urbanisme, Environnement (LAVUE), École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV)-École nationale supérieure d'architecture de Paris Val-de-Seine (ENSA PVDS)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Ministère de la Culture (MC)-Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS), École nationale supérieure d'architecture de Lyon (ENSAL), Ministère de la Culture et de la communication, Université Paris 8 Vincennes-Saint-Denis (UP8)-École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris Nanterre (UPN)-École nationale supérieure d'architecture de Paris Val-de-Seine (ENSA PVDS)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC)-Université Paris 8 Vincennes-Saint-Denis (UP8)-École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris Nanterre (UPN)-École nationale supérieure d'architecture de Paris Val-de-Seine (ENSA PVDS)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Ecole d'architecture de Paris-La Villette, HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris Nanterre (UPN)-École nationale supérieure d'architecture de Paris Val-de-Seine (ENSA PVDS)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC), Centre National de la Recherche Scientifique (CNRS)-Université Paris Nanterre (UPN)-Ministère de la Culture (MC)-Université Paris 8 Vincennes-Saint-Denis (UP8)-École nationale supérieure d'architecture de Paris Val-de-Seine (ENSA PVDS)-École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Nanterre (UPN)-Ministère de la Culture (MC)-Université Paris 8 Vincennes-Saint-Denis (UP8)-École nationale supérieure d'architecture de Paris Val-de-Seine (ENSA PVDS)-École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV), Centre National de la Recherche Scientifique (CNRS)-Université Paris Nanterre (UPN)-Ministère de la Culture (MC)-Université Paris 8 Vincennes-Saint-Denis (UP8)-École nationale supérieure d'architecture de Paris Val-de-Seine (ENSA PVDS)-École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV), Centre National de la Recherche Scientifique (CNRS)-Université Paris Nanterre (UPN)-Ministère de la Culture (MC)-Université Paris 8 Vincennes-Saint-Denis (UP8)-École nationale supérieure d'architecture de Paris Val-de-Seine (ENSA PVDS)-École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Nanterre (UPN)-Ministère de la Culture (MC)-Université Paris 8 Vincennes-Saint-Denis (UP8)-École nationale supérieure d'architecture de Paris Val-de-Seine (ENSA PVDS)-École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université (HESAM)-HESAM Université (HESAM)-Ecole d'architecture de Paris-La Villette, and Documentation, Lavue

Subjects
[SHS.ARCHI]Humanities and Social Sciences/Architecture, space management, [SHS.SOCIO]Humanities and Social Sciences/Sociology, [SHS.SOCIO] Humanities and Social Sciences/Sociology, [SHS.GEO] Humanities and Social Sciences/Geography, [SHS.GEO]Humanities and Social Sciences/Geography, [SHS.ARCHI] Humanities and Social Sciences/Architecture, space management
Abstract

Rapport final de recherche

Published
2016

15. Integration and Quality in Transformations of Urban Space

Author

Morelli, Roberta, Centre de Recherche sur l'Habitat (CRH), Laboratoire Architecture, Ville, Urbanisme, Environnement (LAVUE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Nanterre (UPN)-Ministère de la Culture (MC)-Université Paris 8 Vincennes-Saint-Denis (UP8)-École nationale supérieure d'architecture de Paris Val-de-Seine (ENSA PVDS)-École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Nanterre (UPN)-Ministère de la Culture (MC)-Université Paris 8 Vincennes-Saint-Denis (UP8)-École nationale supérieure d'architecture de Paris Val-de-Seine (ENSA PVDS)-École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV), École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV)-École nationale supérieure d'architecture de Paris Val-de-Seine (ENSA PVDS)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Ministère de la Culture (MC)-Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS)-École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV)-École nationale supérieure d'architecture de Paris Val-de-Seine (ENSA PVDS)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Ministère de la Culture (MC)-Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS), Université Paris 8 Vincennes-Saint-Denis (UP8)-École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris Nanterre (UPN)-École nationale supérieure d'architecture de Paris Val-de-Seine (ENSA PVDS)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC)-Université Paris 8 Vincennes-Saint-Denis (UP8)-École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV), and HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris Nanterre (UPN)-École nationale supérieure d'architecture de Paris Val-de-Seine (ENSA PVDS)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture (MC)

Subjects
[SHS.ARCHI]Humanities and Social Sciences/Architecture, space management
Abstract

International audience; Comment la complexité de la réalité contemporaine peut (et doit) changer la manière d’aborder la transformation urbaine ? La définition de l’approche multi‑scalaire et intégrée proposée ici répond à la volonté de dépasser les limites des analyses sectorielles, à travers la mise au point d’un outil d’évaluation de la qualité des projets urbains et architecturaux.

Published
2012

16. Criteri di integrazione nelle trasformazioni dello spazio urbano

Author

Morelli, Roberta <1976> and Mingucci, Roberto

Subjects
ICAR/14 Composizione architettonica e urbana
Abstract

La tesi di ricerca, a partire dallo studio di aspetti concettuali e metodologici connessi al progetto dello spazio urbano, in termini di elementi spaziali, tipologie di prodotti e processi della progettazione, si propone di definire i temi critici di un approccio progettuale integrato, quali contributi alla base di una proposta di revisione della lettura dei criteri della composizione architettonica e urbana. L'approfondimento dei principi posti alla base della qualità dello spazio urbano - intesa secondo un'accezione ampia del termine entro cui far convergere il tema della sostenibilità - ha indotto a condurre una riflessione specifica sull'incidenza dell'interazione tra fattori progettuali e procedurali, secondo una visione sistemica che sposta l'attenzione dagli oggetti alle relazioni, quali elementi chiave della comprensione delle dinamiche urbane. L'analisi critica di esperienze applicative esemplari selezionate nel contesto europeo, riferita agli stessi temi critici dell'integrazione offre uno strumento essenziale di indagine, approfondimento e verifica puntuale di indirizzi e linee strategiche, utile anche per l'individuazione di un percorso preventivo di analisi degli elementi significativi del controllo del progetto. La valutazione comparata dei casi, mettendo in relazione interventi a scala urbana e specifiche realizzazioni a scala architettonica, si propone di evidenziare come l'efficacia delle strategie più generali possa tradursi nel valore dei progetti di dettaglio solo attraverso un approccio metodologico integrato, capace di incidere profondamente e proficuamente sulla qualità delle trasformazioni dello spazio urbano. Porsi in un atteggiamento critico capace di interpretare la complessità della realtà contemporanea secondo una prospettiva a-scalare della progettazione, rappresenta la condizione essenziale per promuovere e valorizzare una creatività progettuale capace di definire scenari contemporanei e futuri più responsabili e consapevoli.

Published
2010

17. Criteri di integrazione nelle trasformazioni dello spazio urbano

Author

Mingucci, Roberto, Morelli, Roberta <1976>, Mingucci, Roberto, and Morelli, Roberta <1976>

Abstract

La tesi di ricerca, a partire dallo studio di aspetti concettuali e metodologici connessi al progetto dello spazio urbano, in termini di elementi spaziali, tipologie di prodotti e processi della progettazione, si propone di definire i temi critici di un approccio progettuale integrato, quali contributi alla base di una proposta di revisione della lettura dei criteri della composizione architettonica e urbana. L'approfondimento dei principi posti alla base della qualità dello spazio urbano - intesa secondo un'accezione ampia del termine entro cui far convergere il tema della sostenibilità - ha indotto a condurre una riflessione specifica sull'incidenza dell'interazione tra fattori progettuali e procedurali, secondo una visione sistemica che sposta l'attenzione dagli oggetti alle relazioni, quali elementi chiave della comprensione delle dinamiche urbane. L'analisi critica di esperienze applicative esemplari selezionate nel contesto europeo, riferita agli stessi temi critici dell'integrazione offre uno strumento essenziale di indagine, approfondimento e verifica puntuale di indirizzi e linee strategiche, utile anche per l'individuazione di un percorso preventivo di analisi degli elementi significativi del controllo del progetto. La valutazione comparata dei casi, mettendo in relazione interventi a scala urbana e specifiche realizzazioni a scala architettonica, si propone di evidenziare come l'efficacia delle strategie più generali possa tradursi nel valore dei progetti di dettaglio solo attraverso un approccio metodologico integrato, capace di incidere profondamente e proficuamente sulla qualità delle trasformazioni dello spazio urbano. Porsi in un atteggiamento critico capace di interpretare la complessità della realtà contemporanea secondo una prospettiva a-scalare della progettazione, rappresenta la condizione essenziale per promuovere e valorizzare una creatività progettuale capace di definire scenari contemporanei e futuri più responsabili e consapevoli.

Published
2010

20. INTRODUCTION.

Author

Morelli, Roberta and Strangio, Donatella

Abstract

The article discusses the concepts of mega events and large exhibitions, as well as the logistical aspects of organizing such events. Topics discussed include the role of economics in organizing large scale events, the role of urban transformation and public spaces, and the frequency of events.

Published
2013

21. Effects of a Synbiotic Formula on Functional Bowel Disorders and Gut Microbiota Profile during Long-Term Home Enteral Nutrition (LTHEN): A Pilot Study.

Author

D'Onofrio, Valentina, Del Chierico, Federica, Belci, Paola, Vernocchi, Pamela, Quagliariello, Andrea, Reddel, Sofia, Conta, Giorgia, Mancino, Maria Vittoria, Fadda, Maurizio, Scigliano, Maria Carmine, Morelli, Roberta, De Francesco, Antonella, Guagnini, Fabio, Fassio, Filippo, Galletti, Rosalba, and Putignani, Lorenza

Abstract

Long-term enteral nutrition (LTEN) can induce gut microbiota (GM) dysbiosis and gastrointestinal related symptoms, such as constipation or diarrhoea. To date, the treatment of constipation is based on the use of laxatives and prebiotics. Only recently have probiotics and synbiotics been considered, the latter modulating the GM and regulating intestinal functions. This randomized open-label intervention study evaluated the effects of synbiotic treatment on the GM profile, its functional activity and on intestinal functions in long-term home EN (LTHEN) patients. Twenty LTHEN patients were recruited to take enteral formula plus one sachet/day of synbiotic (intervention group, IG) or enteral formula (control group, CG) for four months and evaluated for constipation, stool consistency, and GM and metabolite profiles. In IG patients, statistically significant reduction of constipation and increase of stool consistency were observed after four months (T1), compared to CG subjects. GM ecology analyses revealed a decrease in the microbial diversity of both IC and CG groups. Biodiversity increased at T1 for 5/11 IG patients and Methanobrevibacter was identified as the biomarker correlated to the richness increase. Moreover, the increase of short chain fatty acids and the reduction of harmful molecules have been correlated to synbiotic administration. Synbiotics improve constipation symptoms and influences Methanobrevibacter growth in LTHEN patients. [ABSTRACT FROM AUTHOR]

Published
2021
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23. The two Italies (Book Review).

Author

Morelli, Roberta

Subjects
INTERNATIONAL economic relations, NONFICTION
Abstract

Reviews the book "The Two Italies: Economic Relations Between the Norman Kingdom of Sicily and the Northern Communes," by David Abulafia.

Published
1978

25. Impact of parvovirus B19 outbreak in a single center.

Author

Faiola S, Morelli R, Casati, Laoreti A, Lanna M, and Maria Savasi V

Abstract

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Published
2024
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26. Effects of a Synbiotic Formula on Functional Bowel Disorders and Gut Microbiota Profile during Long-Term Home Enteral Nutrition (LTHEN): A Pilot Study.

Author

D'Onofrio V, Del Chierico F, Belci P, Vernocchi P, Quagliariello A, Reddel S, Conta G, Mancino MV, Fadda M, Scigliano MC, Morelli R, De Francesco A, Guagnini F, Fassio F, Galletti R, and Putignani L

Subjects
Aged, Biodiversity, Constipation, Dysbiosis, Fatty Acids, Volatile, Feces microbiology, Female, Humans, Italy, Male, Pilot Projects, Prebiotics, Probiotics, Surveys and Questionnaires, Synbiotics, Enteral Nutrition, Food, Formulated, Gastrointestinal Microbiome, Irritable Bowel Syndrome microbiology
Abstract

Long-term enteral nutrition (LTEN) can induce gut microbiota (GM) dysbiosis and gastrointestinal related symptoms, such as constipation or diarrhoea. To date, the treatment of constipation is based on the use of laxatives and prebiotics. Only recently have probiotics and synbiotics been considered, the latter modulating the GM and regulating intestinal functions. This randomized open-label intervention study evaluated the effects of synbiotic treatment on the GM profile, its functional activity and on intestinal functions in long-term home EN (LTHEN) patients. Twenty LTHEN patients were recruited to take enteral formula plus one sachet/day of synbiotic (intervention group, IG) or enteral formula (control group, CG) for four months and evaluated for constipation, stool consistency, and GM and metabolite profiles. In IG patients, statistically significant reduction of constipation and increase of stool consistency were observed after four months (T 1 ), compared to CG subjects. GM ecology analyses revealed a decrease in the microbial diversity of both IC and CG groups. Biodiversity increased at T 1 for 5/11 IG patients and Methanobrevibacter was identified as the biomarker correlated to the richness increase. Moreover, the increase of short chain fatty acids and the reduction of harmful molecules have been correlated to synbiotic administration. Synbiotics improve constipation symptoms and influences Methanobrevibacter growth in LTHEN patients.

Published
2020
Full Text
View/download PDF

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