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3. Biochemical and Anthropometric Outcomes in Paediatric Patients with Heterozygous Familial Hypercholesterolemia after COVID-19 Pandemic Lockdowns: An Exploratory Analysis.

Author

Peres, Maria, Moreira-Rosário, André, Padeira, Gonçalo, Gaspar Silva, Patrícia, Correia, Carla, Nunes, Andreia, Garcia, Elisabete, Faria, Ana, Teixeira, Diana, Calhau, Conceição, Pereira-da-Silva, Luís, Cristina Ferreira, Ana, and César Rocha, Júlio

Abstract

The COVID-19 pandemic lockdowns affected the lifestyles of children and adolescents, leading to an increase in childhood obesity. Paediatric patients with familial hypercholesterolemia (FH) may be more susceptible to lockdown effects due to their increased cardiovascular risk. However, data are lacking. We investigated the effect of lockdowns on the metabolic profile of paediatric patients with FH. Blood lipids and anthropometry measured in September 2021–April 2022 were retrospectively compared with pre-pandemic values. Thirty participants were included (1–16 years; 57% female). From baseline to post-pandemic, median [P25, P75] blood LDL-C concentration was 125 [112, 150] mg/dL vs. 125 [100, 147] mg/dL (p = 0.894); HDL-C was 58 [52, 65] mg/dL vs. 56 [51, 61] mg/dL (p = 0.107); triglycerides were 64 [44, 86] mg/dL vs. 59 [42, 86] mg/dL (p = 0.178). The BMI z-score did not change significantly (0.19 [−0.58, 0.89] vs. 0.30 [−0.48, 1.10], p = 0.524). The lack of deterioration in metabolic profiles during lockdowns is positive, as some deterioration was expected. We speculate that patients and caregivers were successfully educated about healthy lifestyle and dietary habits. Our results should be interpreted with caution since the study sample was small and heterogeneous. Multicentre research is needed to better understand the impact of lockdowns on this population. [ABSTRACT FROM AUTHOR]

Published
2024
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5. The Effect of Unadjusted Mineral Supplementation on Bone Health of Preterm Infants Fed Fortified Human Milk: An Exploratory Analysis.

Author

Cardoso, Manuela, Figueiredo, Leonor, Moreira‑Rosário, André, Camolas, José, Virella, Daniel, Macedo, Israel, and Pereira‑da‑Silva, Luís

Subjects
METABOLIC bone disorders, BONE health, BONE growth, PREMATURE infants, BREAST milk
Abstract

Background: In standard fortification of human milk (HM), the HM macronutrient content is assumed, and a fixed amount of a multinutrient fortifier is added to achieve recommended nutrient intakes. In target fortification, the HM macronutrient content is regularly measured, guiding the addition of modular macronutrient supplements to the fortified HM, to achieve the nutritional targets more precisely. Objective: The study aimed to investigate whether this addition of modular supplements, unaccompanied by mineral supplementation, predispose to metabolic bone disease (MBD). Methods: This is a secondary analysis of a larger study of infants born with <33 weeks gestational age. Fortifications based on the assumed (Group 1) or measured (Group 2) of the HM macronutrient content were compared, using low serum phosphate levels as an indicator of MBD, and length growth as a surrogate of bone growth. Results: Eighty‑four infants were included, 35 in Group 1 and 49 in Group 2. During the exposure period, infants of Group 2 received higher mean fat (6.1 vs. 5.3 g/kg/day, P < 0.001) and carbohydrate (13.0 vs. 11.7 g/kg/day, P < 0.001) intakes; in addition, they exhibited lower mean serum phosphate (5.5 vs. 6.0 mg/dL, P = 0.022) and faster mean length velocity (1.06 vs. 0.89 cm/week, P = 0.003). Conclusions: These findings suggest that feeding fortified HM with extra fat and carbohydrate content, unaccompanied by mineral supplementation, promotes increased bone growth, as indicated by accelerated length growth, but with insufficiently mineralized osteoid, indicated by low serum phosphate levels. Intervention studies using direct biomarkers of bone mass content and mineral density are necessary to corroborate our findings. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Children’s performance on Raven’s Coloured progressive matrices in Portugal: The Flynn effect

Author

Carvalho, Irene P., Costa, Ana, Silva, Sofia, Moreira, Bárbara, Almeida, Agostinho, Moreira-Rosário, André, Guerra, António, Peixoto, Bruno, Delerue-Matos, Cristina, Sintra, Diana, Pestana, Diogo, Pinto, Edgar, Mendes, Francisca de Castro, Martins, Inês, Leite, João Costa, Caldas, José Carlos, Fontoura, Manuel, Maia, Maria Luz, Queirós, Pedro, Moreira, Roxana, Leal, Sandra, Norberto, Sónia, Costa, Vera da, Fernandes, Virgínia Cruz, Keating, Elisa, Azevedo, Luís F., and Calhau, Conceição

Published
2020
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7. Empowerment-based nutrition interventions on blood pressure: a randomized comparative effectiveness trial

Author

Moreira-Rosário, André, primary, Ismael, Shámila, additional, Barreiros-Mota, Inês, additional, Morais, Juliana, additional, Rodrigues, Catarina, additional, Castela, Inês, additional, Mendes, Inês Curvelo, additional, Soares, Maria Inês, additional, da Costa, Luís Soares, additional, Oliveira, Catarina Batista, additional, Henriques, Tiago, additional, Pinto, Patrícia, additional, Pita, Débora, additional, de Oliveira, Catarina Marques, additional, Maciel, Janaína, additional, Serafim, Thaina, additional, Araújo, João, additional, Rocha, Júlio César, additional, Pestana, Diogo, additional, Silvestre, Marta P., additional, Marques, Cláudia, additional, Faria, Ana, additional, Polonia, Jorge, additional, and Calhau, Conceição, additional

Published
2023
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8. Essential Trace Elements Status in Portuguese Pregnant Women and Their Association with Maternal and Neonatal Outcomes: A Prospective Study from the IoMum Cohort

Author

Bracchi, Isabella, primary, Guimarães, Juliana, additional, Rodrigues, Catarina, additional, Azevedo, Rui, additional, Coelho, Cláudia Matta, additional, Pinheiro, Cátia, additional, Morais, Juliana, additional, Barreiros-Mota, Inês, additional, Fernandes, Virgínia Cruz, additional, Delerue-Matos, Cristina, additional, Pinto, Edgar, additional, Moreira-Rosário, André, additional, de Azevedo, Luís Filipe Ribeiro, additional, Dias, Cláudia Camila, additional, Lima, Jorge, additional, Sapinho, Inês, additional, Ramalho, Carla, additional, Calhau, Conceição, additional, Leite, João Costa, additional, Almeida, Agostinho, additional, Pestana, Diogo, additional, and Keating, Elisa, additional

Published
2023
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9. Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 disease severity

Author

Freitas, Ana Teresa, Calhau, Conceição, Antunes, Gonçalo, Araújo, Beatriz, Bandeira, Matilde, Barreira, Sofia, Bazenga, Filipa, Braz, Sandra, Caldeira, Daniel, Santos, Susana Constantino Rosa, Faria, Ana, Faria, Daniel, Fraga, Marta, Nogueira-Garcia, Beatriz, Gonçalves, Lúcia, Kovalchuk, Pavlo, Lacerda, Luísa, Lopes, Hugo, Luís, Daniel, Medeiros, Fábio, Melo, Ana M. P., Melo-Cristino, José, Miranda, Ana, Pereira, Clara, Pinto, Ana Teresa, Pinto, João, Proença, Helena, Ramos, Angélica, Rato, João P. R., Rocha, Filipe, Rocha, Júlio César, Moreira-Rosário, André, Vazão, Helena, Volovetska, Yuliya, Guimarães, João-Tiago, and Pinto, Fausto J.

Published
2021
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12. Body Composition Evaluation and Clinical Markers of Cardiometabolic Risk in Patients with Phenylketonuria.

Author

Luengo-Pérez, Luis M., Fernández-Bueso, Mercedes, Ambrojo, Ana, Guijarro, Marta, Ferreira, Ana Cristina, Pereira-da-Silva, Luís, Moreira-Rosário, André, Faria, Ana, Calhau, Conceição, Daly, Anne, MacDonald, Anita, and Rocha, Júlio César

Abstract

Cardiovascular diseases are the main cause of mortality worldwide. Patients with phenylketonuria (PKU) may be at increased cardiovascular risk. This review provides an overview of clinical and metabolic cardiovascular risk factors, explores the connections between body composition (including fat mass and ectopic fat) and cardiovascular risk, and examines various methods for evaluating body composition. It particularly focuses on nutritional ultrasound, given its emerging availability and practical utility in clinical settings. Possible causes of increased cardiometabolic risk in PKU are also explored, including an increased intake of carbohydrates, chronic exposure to amino acids, and characteristics of microbiota. It is important to evaluate cardiovascular risk factors and body composition in patients with PKU. We suggest systematic monitoring of body composition to develop nutritional management and hydration strategies to optimize performance within the limits of nutritional therapy. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Systematic Review and Meta-Analysis

Author

Rodrigues, Tânia, Rodrigues Fialho, Sofia, Araújo, João Ricardo, Rocha, Rita, Moreira-Rosário, André, Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS), and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
irritable bowel syndrome, meta-analysis, Medicine(all), randomized controlled trials, fecal microbiota transplantation, microbiome therapy
Abstract

Funding Information: This work was sponsored by national funds through FCT, Fundação para a Ciência e a Tecnologia, I.P., within the scope of the projects CINTESIS, R&D Unit (reference UIDB/4255/2020) and “RISE—LA/P/0053/2020”. Background: Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disease with no effective treatment. Altered microbiota composition seems implicated in disease etiology and therefore fecal microbial transplantation (FMT) has emerged as a possible treatment therapy. To clarify the clinical parameters impacting FMT efficacy, we conducted a systematic review with subgroup analysis. Methods: A literature search was performed identifying randomized controlled trials (RCTs) comparing FMT with placebo in IBS adult patients (8-week follow-up) with a reported improvement in global IBS symptoms. Results: Seven RCTs (489 participants) met the eligibility requirements. Although FMT seems not to be effective in global improvement of IBS symptoms, subgroup analysis shows that FMT through gastroscopy or nasojejunal tube are effective IBS treatments (RR 3.03; 95% CI 1.94–4.73; I2 = 10%, p < 0.00001). When considering non-oral ingestion routes, IBS patients with constipation symptoms are more likely to benefit from FMT administration (p = 0.003 for the difference between IBS subtypes regarding constipation). Fresh fecal transplant and bowel preparation seem also to have impact on FMT efficacy (p = 0.03 and p = 0.01, respectively). Conclusion: Our meta-analysis revealed a set of critical steps that could affect the efficacy of FMT as clinical procedure to treat IBS, nevertheless more RCTs are needed. publishersversion published

Published
2023

15. A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Author

Schadow, Alena M, Revheim, Ingrid, Spielau, Ulrike, Dierkes, Jutta, Schwingshackl, Lukas, Frank, Jan, Hodgson, Jonathan M, Moreira-Rosário, André, Seal, Chris J, Buyken, Anette E, Rosendahl-Riise, Hanne, Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS), and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
Adult, Glycated Hemoglobin, Dietary Fiber, Diabetes Mellitus, Type 2, SDG 3 - Good Health and Well-being, Cardiovascular Diseases, Humans, Insulin, Bread, Blood Glucose/analysis, Randomized Controlled Trials as Topic
Abstract

Copyright © 2022. Published by Elsevier Inc. Bread is a major source of grain-derived carbohydrates worldwide. High intakes of refined grains, low in dietary fiber and high in glycemic index, are linked with increased risk for type 2 diabetes mellitus (T2DM) and other chronic diseases. Hence, improvements in the composition of bread could influence population health. This systematic review evaluated the effect of regular consumption of reformulated breads on glycemic control among healthy adults, adults at cardiometabolic risk or with manifest T2DM. A literature search was performed using MEDLINE, Embase, Web of Science and the Cochrane Central Register of Controlled Trials. Eligible studies employed a bread intervention (≥2 wk) in adults (healthy, at cardiometabolic risk or manifest T2DM) and reported glycemic outcomes (fasting blood glucose, fasting insulin, HOMA-IR, HbA1c, and postprandial glucose responses). Data were pooled using generic inverse variance with random-effects model and presented as mean difference (MD) or standardized MD between treatments with 95% CIs. Twenty-two studies met the inclusion criteria (n = 1037 participants). Compared with "regular" or comparator bread, consumption of reformulated intervention breads yielded lower fasting blood glucose concentrations (MD: -0.21 mmol/L; 95% CI: -0.38, -0.03; I2 = 88%, moderate certainty of evidence), yet no differences in fasting insulin (MD: -1.59 pmol/L; 95% CI: -5.78, 2.59; I2 = 38%, moderate certainty of evidence), HOMA-IR (MD: -0.09; 95% CI: -0.35, 0.23; I2 = 60%, moderate certainty of evidence), HbA1c (MD: -0.14; 95% CI: -0.39, 0.10; I2 = 56%, very low certainty of evidence), or postprandial glucose response (SMD: -0.46; 95% CI: -1.28, 0.36; I2 = 74%, low certainty of evidence). Subgroup analyses revealed a beneficial effect for fasting blood glucose only among people with T2DM (low certainty of evidence). Our findings suggest a beneficial effect of reformulated breads high in dietary fiber, whole grains, and/or functional ingredients on fasting blood glucose concentrations in adults, primarily among those with T2DM. This trial was registered at PROSPERO as CRD42020205458. publishersversion published

Published
2023

16. Association between Elevated Iodine Intake and IQ among School Children in Portugal

Author

Carvalho, Irene P., primary, Peixoto, Bruno, additional, Caldas, José Carlos, additional, Costa, Ana, additional, Silva, Sofia, additional, Moreira, Bárbara, additional, Almeida, Agostinho, additional, Moreira-Rosário, André, additional, Guerra, António, additional, Delerue-Matos, Cristina, additional, Sintra, Diana, additional, Pestana, Diogo, additional, Pinto, Edgar, additional, Mendes, Francisca Castro, additional, Martins, Inês, additional, Leite, João Costa, additional, Fontoura, Manuel, additional, Maia, Maria Luz, additional, Queirós, Pedro, additional, Moreira, Roxana, additional, Leal, Sandra, additional, Norberto, Sónia, additional, Costa, Vera, additional, Fernandes, Virgínia Cruz, additional, Keating, Elisa, additional, Azevedo, Luís, additional, and Calhau, Conceição, additional

Published
2022
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18. Is the Phenylalanine-Restricted Diet a Risk Factor for Overweight or Obesity in Patients with Phenylketonuria (PKU)? A Systematic Review and Meta-Analysis

Author

Rodrigues, Catarina, Pinto, Alex, Faria, Ana, Teixeira, Diana, van Wegberg, Annemiek M.J., Ahring, Kirsten, Feillet, François, Calhau, Conceição, MacDonald, Anita, Moreira-Rosário, André, Rocha, Júlio César, Comprehensive Health Research Centre (CHRC) - pólo NMS, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
obesity, Nutrition and Dietetics, SDG 3 - Good Health and Well-being, phenylketonuria, nutritional and metabolic diseases, overweight, body mass index, phenylalanine-restricted diet, phenylalanine restriction, Food Science
Abstract

Funding: CINTESIS—UIDB/4255/2020 a program financially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência, through national funds is acknowledged. Support from Human Nutrition and Metabolism Master Program from NOVA Medical School, Universidade Nova de Lisboa is ackowledged. Although there is a general assumption that a phenylalanine (Phe)-restricted diet promotes overweight in patients with phenylketonuria (PKU), it is unclear if this presumption is supported by scientific evidence. This systematic review aimed to determine if patients with PKU are at a higher risk of overweight compared to healthy individuals. A literature search was carried out on PubMed, Cochrane Library, and Embase databases. Risk of bias of individual studies was assessed using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies, and the quality of the evidence for each outcome was assessed using the NutriGrade scoring system. From 829 articles identified, 15 were included in the systematic review and 12 in the meta-analysis. Body mass index (BMI) was similar between patients with PKU and healthy controls, providing no evidence to support the idea that a Phe-restricted diet is a risk factor for the development of overweight. However, a subgroup of patients with classical PKU had a significantly higher BMI than healthy controls. Given the increasing prevalence of overweight in the general population, patients with PKU require lifelong follow-up, receiving personalised nutritional counselling, with methodical nutritional status monitoring from a multidisciplinary team in inherited metabolic disorders. publishersversion published

Published
2021

19. Is the Phenylalanine-Restricted Diet a Risk Factor for Overweight or Obesity in Patients with Phenylketonuria (PKU)? A Systematic Review and Meta-Analysis

Author

Rodrigues, Catarina, primary, Pinto, Alex, additional, Faria, Ana, additional, Teixeira, Diana, additional, van Wegberg, Annemiek M. J., additional, Ahring, Kirsten, additional, Feillet, François, additional, Calhau, Conceição, additional, MacDonald, Anita, additional, Moreira-Rosário, André, additional, and Rocha, Júlio César, additional

Published
2021
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20. Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients

Author

Moreira-Rosário, André, primary, Marques, Cláudia, additional, Pinheiro, Hélder, additional, Araújo, João Ricardo, additional, Ribeiro, Pedro, additional, Rocha, Rita, additional, Mota, Inês, additional, Pestana, Diogo, additional, Ribeiro, Rita, additional, Pereira, Ana, additional, de Sousa, Maria José, additional, Pereira-Leal, José, additional, de Sousa, José, additional, Morais, Juliana, additional, Teixeira, Diana, additional, Rocha, Júlio César, additional, Silvestre, Marta, additional, Príncipe, Nuno, additional, Gatta, Nuno, additional, Amado, José, additional, Santos, Lurdes, additional, Maltez, Fernando, additional, Boquinhas, Ana, additional, de Sousa, Germano, additional, Germano, Nuno, additional, Sarmento, Gonçalo, additional, Granja, Cristina, additional, Póvoa, Pedro, additional, Faria, Ana, additional, and Calhau, Conceição, additional

Published
2021
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21. Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 infection severity

Author

Freitas, Ana Teresa, primary, Calhau, Conceição, additional, Antunes, Gonçalo, additional, Araújo, Beatriz, additional, Bandeira, Matilde, additional, Barreira, Sofia, additional, Bazenga, Filipa, additional, Braz, Sandra, additional, Caldeira, Daniel, additional, Santos, Susana Constantino Rosa, additional, Faria, Ana, additional, Faria, Daniel, additional, Fraga, Marta, additional, Nogueira-Garcia, Beatriz, additional, Gonçalves, Lúcia, additional, Kovalchuk, Pavlo, additional, Lacerda, Luísa, additional, Lopes, Hugo, additional, Luís, Daniel, additional, Medeiros, Fábio, additional, Melo, Ana M. P., additional, Melo-Cristino, José, additional, Miranda, Ana, additional, Pereira, Clara, additional, Pinto, Ana Teresa, additional, Pinto, João, additional, Proença, Helena, additional, Ramos, Angélica, additional, P. R. Rato, João, additional, Rocha, Filipe, additional, César Rocha, Júlio, additional, Moreira-Rosário, André, additional, Vazão, Helena, additional, Volovetska, Yuliya, additional, Guimarães, João-Tiago, additional, and Pinto, Fausto, additional

Published
2021
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22. Iodine knowledge is associated with iodine status in Portuguese pregnant women: results from the IoMum cohort study

Author

Pinheiro, Cátia, primary, Xavier Moreira, Nara, additional, Ferreira, Pedro, additional, Matta Coelho, Cláudia, additional, Guimarães, Juliana, additional, Pereira, Gonçalo, additional, Cortez, Alice, additional, Bracchi, Isabella, additional, Pestana, Diogo, additional, Barreiros Mota, Inês, additional, Prucha, Carmo, additional, Martins, Cristina, additional, Alves Ribeiro, Célia, additional, Pinto, Edgar, additional, Almeida, Agostinho, additional, Delerue-Matos, Cristina, additional, Montenegro, Nuno, additional, Dias, Cláudia Camila, additional, Moreira-Rosário, André, additional, Azevedo, Luís Filipe, additional, Brantsæter, Anne-Lise, additional, Ramalho, Carla, additional, Cruz Fernandes, Virgínia, additional, Costa Leite, João, additional, Calhau, Conceição, additional, and Keating, Elisa, additional

Published
2021
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23. The association of milk and dairy consumption with iodine status in pregnant women in Oporto region

Author

Ferreira, Pedro, primary, Pinheiro, Cátia, additional, Matta Coelho, Cláudia, additional, Guimarães, Juliana, additional, Pereira, Gonçalo, additional, Xavier Moreira, Nara, additional, Cortez, Alice, additional, Bracchi, Isabella, additional, Pestana, Diogo, additional, Barreiros Mota, Inês, additional, Prucha, Carmo, additional, Martins, Cristina, additional, Alves Ribeiro, Célia, additional, Pinto, Edgar, additional, Almeida, Agostinho, additional, Delerue-Matos, Cristina, additional, Montenegro, Nuno, additional, Dias, Cláudia Camila, additional, Moreira-Rosário, André, additional, Azevedo, Luís Filipe, additional, Brantsæter, Anne-Lise, additional, Ramalho, Carla, additional, Cruz Fernandes, Virgínia, additional, Calhau, Conceição, additional, Costa Leite, João, additional, and Keating, Elisa, additional

Published
2021
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26. Iodine Status and Iodised Salt Consumption in Portuguese School-Aged Children: The Iogeneration Study

Author

Costa Leite, João, primary, Keating, Elisa, additional, Pestana, Diogo, additional, Cruz Fernandes, Virgínia, additional, Maia, Maria, additional, Norberto, Sónia, additional, Pinto, Edgar, additional, Moreira-Rosário, André, additional, Sintra, Diana, additional, Moreira, Bárbara, additional, Costa, Ana, additional, Silva, Sofia, additional, Costa, Vera, additional, Martins, Inês, additional, Castro Mendes, Francisca, additional, Queirós, Pedro, additional, Peixoto, Bruno, additional, Carlos Caldas, José, additional, Guerra, António, additional, Fontoura, Manuel, additional, Leal, Sandra, additional, Moreira, Roxana, additional, Palmares Carvalho, Irene, additional, Matias Lima, Rui, additional, Martins, Catia, additional, Delerue-Matos, Cristina, additional, Almeida, Agostinho, additional, Azevedo, Luís, additional, and Calhau, Conceição, additional

Published
2017
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