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Treatment resistant depression (TRD) is a subgroup of Major Depressive Disorder that does not respond to typical or first-line treatment approaches. Treatment-resistant depression is diagnosed when two appropriate antidepressant therapies fail. TRD may also be connected to lengthy stays in a hospital for medical attention. To distinguish authentic TRD, a number of definitions and standards have been presented, but no single definition or standard has yet gained acceptance. As a result, TRD poses unique difficulties for therapeutic strategies and efficient therapies. Recent meta-analyses, original studies of the PubMed literature were compiled. In this article, we'll try to give a comprehensive overview of TRD treatment options and discuss the difficulties that come with treating this condition. [ABSTRACT FROM AUTHOR]

Munchausen Syndrome (MS) has been a medical entity since its discovery and has aroused curiosity in the medical world. The difficulty in diagnosing and treatment falls within the realm of severe psychiatric disorders. The individual simulates certain diseases in order to become a patient and to attract the attention and assistance of medical staff. The subject does not seek to obtain material or financial benefits. Its characteristic element is the repeated or exaggerated mimicry of the symptoms of an acute organic disease, as well as the falsification of laboratory tests in search of a treatment. The factual post-traumatic stress syndrome offers patients with MS a role as both a victim and a hero, and they receive understanding and respect from society. With the help of specific psychological tests, the clinician can determine if the symptoms are claimed or true, and finding an external motivation, such as financial motivation, makes it possible to differentiate the simulation from the true MS. [ABSTRACT FROM AUTHOR]

This article describes the case of a 48-year-old female patient who was involuntary admitted by the authorities for a psychotic episode characterized by delusional ideas of grandeur, filiation and reference. The patient firmly believed that she was not only a member of the royal family of Monaco, but also had a special familial connection to the ruling dynasty. This case highlights the complexities of psychotic disorders and the presence of multiple delusional themes that can significantly impact an individual's perception of reality and functioning. These delusions profoundly affected the patient's daily life and interpersonal relationships. Her strong conviction in her royal filiation led to strained interactions with family members, who were unable to validate her claims. The patient's preoccupation with her imagined connection to the royal family overshadowed her personal responsibilities, causing disruptions in her overall functioning. This paper underscores the intricate nature of psychotic disorders and the multifaceted delusions that can arise within them. Understanding the interplay between these delusional themes is vital in guiding diagnosis and treatment strategies. By implementing a comprehensive approach that includes medication, psychotherapy, and a supportive environment, healthcare professionals can assist patients in regaining a more accurate perception of reality and improve overall functioning and well-being. [ABSTRACT FROM AUTHOR]

Schizophrenia is a serious and complex mental disorder that not only affects one's ability to perceive reality, but also leads to emotional and behavioral disturbances. The main feature of schizophrenia is represented by the existence of psychotic symptoms, such as hallucinations and/or delusions which need immediate psychiatric care. Schizophrenia involves a significant lack of insight and non-adherence to treatment, resulting in multiple relapses and hospitalizations and consequently leading to unfavorable outcomes. This article will present the clinical case of a 54-year-old woman, diagnosed with paranoid schizophrenia, who presents herself together with her son to the ER of "Socola" Institute of Psychiatry due to an aggravation of symptoms. This case illustrates a situation that had a favorable outcome, in spite of the several challenges encountered when trying to find a suitable treatment option. Family support played an essential role in this particular matter which resulted in achieving a better level of healing and social functioning. [ABSTRACT FROM AUTHOR]

Alcohol use disorder is a medical condition marked by a diminished capacity to halt or manage alcohol consumption, even in the face of detrimental social, professional, or health outcomes. It encompasses various terms such as alcohol abuse, dependence, addiction, and colloquially, alcoholism. Research has consistently highlighted the significant toll that alcoholism can take on the spouses of individuals struggling with alcohol addiction. Living with a spouse who struggles with alcoholism can be incredibly challenging and emotionally taxing. It can have significant impacts on one's mental and physical health, as well as on the dynamics of the relationship and family life. The typologies of wives of alcoholics categorize the various coping and behavioral patterns these individuals may adopt in response to their spouse's alcoholism, including enabling the behavior, adopting a victim mindset, compensating by being overly competent (the hero), displaying oppositional behavior (the rebel), or withdrawing emotionally and socially to protect themselves. The dynamics of alcoholism in a marriage can erode trust, communication, and intimacy, often leading to a breakdown of the relationship if left unaddressed. Seeking professional help, such as therapy or support groups, can be crucial for both spouses to navigate the challenges of alcoholism and work towards healing and recovery, either individually or as a couple. [ABSTRACT FROM AUTHOR]

Oncological pathologies take a toll on millions of lives throughout the world, with a burden set to spiral in the future. The humanity’s increasing lifespan has pushed physicists to come up with specific and improved methods of treatment, and even more so, aggressive, in order to fight back these cell degenerations. Chemotherapy remains still one of the most effective ways to treat cancer, but the price for health might be even higher than expected. The cognitive repercussions of cancer and its treatment have been under the spotlight for the past 20 years, where scientists focused on getting a deeper understanding of post-chemotherapy effects on the human brain. In this paper we dive into the psychological and psychiatric pathology linked to this treatment method, by examining a clinical case that envisions a resilient woman who overcame cancer, but still encountered some setbacks. [ABSTRACT FROM AUTHOR]

Schizoaffective disorder represents a psychiatric condition characterized by symptoms of both schizophrenia and mood disorders, such as bipolar disorder or depression. Together, these two conditions have a major impact on individuals and affect many aspects of their lives. Moreover, practicians often have difficulties in diagnosing and treating the patients suffering from this disorder. In patients with psychiatric conditions, including schizoaffective disorder, the lack of insight is frequently a significant problem. Objectives: This paper aims to provide a general perspective upon the evolution of schizoaffective disorder and to emphasize the patients' limited capacity to recognise their condition and the need for treatment. Methods: This article will present the clinical case of a 37-year old woman, who is brought by the police to the ER of "Socola" Institute of Psychiatry for psychomotor agitation, emotional lability, mood swings, delusions of prejudice and persecution, impulsive behavior and aggressiveness towards her parents, especially her father. Conclusions: Impairment of insight is considered an important characteristic of psychiatric disorders, including schizoaffective disorder. It is crucial for physicians to develop trusting relationships with both the patient and the patient's family in order to improve the quality of life of both patients and their families. [ABSTRACT FROM AUTHOR]

The spread of COVID 19 across the globe is challenging the capacity of response of all healthcare systems. The uncertainty and the newness af this pandemic provoked a generalized wariness and stress among all categories of population, but mainly among healthcare professionals. Due to the lack of knowledge of the disease, the excessive amount of work, poor resources and depletion of personal protection equipment, the huge media pressure and many other difficulties, healthcare workers(HCW) are at high risk of developing many mental health issues such as anxiety, depression, burnout, post-traumatic stress disorder, sleep disorders, all of which could have a negative long-term psychological impact. In this context, it is important to research and to have an real-time view on this topic, in order to find ways of improving the psycological distress HCW are facing. [ABSTRACT FROM AUTHOR]