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Your search keyword '"Morandotti, G. A."' showing total 20 results
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20 results on '"Morandotti, G. A."'

1. Evaluating the newly developed BioFire COVID-19 test for SARS-CoV-2 molecular detection

Author

Liotti, F. M., Menchinelli, G., Marchetti, S., Morandotti, G. A., Sanguinetti, M., Posteraro, B., Cattani, P., Liotti F. M., Menchinelli G., Marchetti S., Morandotti G. A., Sanguinetti M. (ORCID:0000-0002-9780-7059), Posteraro B. (ORCID:0000-0002-1663-7546), Cattani P. (ORCID:0000-0003-4678-4763), Liotti, F. M., Menchinelli, G., Marchetti, S., Morandotti, G. A., Sanguinetti, M., Posteraro, B., Cattani, P., Liotti F. M., Menchinelli G., Marchetti S., Morandotti G. A., Sanguinetti M. (ORCID:0000-0002-9780-7059), Posteraro B. (ORCID:0000-0002-1663-7546), and Cattani P. (ORCID:0000-0003-4678-4763)

Abstract

N/A

Published
2020

3. Simulated Pediatric Blood Cultures to Assess the Inactivation of Clinically Relevant Antimicrobial Drug Concentrations in Resin-Containing Bottles

Author

Giordano, Lucia, Liotti, Flora Marzia, Menchinelli, Giulia, De Angelis, Giulia, D'Inzeo, Tiziana, Morandotti, Grazia Angela, Sanguinetti, Maurizio, Spanu, Teresa, Posteraro, Brunella, Giordano L., Liotti F. M., Menchinelli G., De Angelis G. (ORCID:0000-0002-7087-7399), D'Inzeo T. (ORCID:0000-0003-1508-3518), Morandotti G. A., Sanguinetti M. (ORCID:0000-0002-9780-7059), Spanu T. (ORCID:0000-0003-1864-5184), Posteraro B. (ORCID:0000-0002-1663-7546), Giordano, Lucia, Liotti, Flora Marzia, Menchinelli, Giulia, De Angelis, Giulia, D'Inzeo, Tiziana, Morandotti, Grazia Angela, Sanguinetti, Maurizio, Spanu, Teresa, Posteraro, Brunella, Giordano L., Liotti F. M., Menchinelli G., De Angelis G. (ORCID:0000-0002-7087-7399), D'Inzeo T. (ORCID:0000-0003-1508-3518), Morandotti G. A., Sanguinetti M. (ORCID:0000-0002-9780-7059), Spanu T. (ORCID:0000-0003-1864-5184), and Posteraro B. (ORCID:0000-0002-1663-7546)

Abstract

The bacteremia level as well as the administration of antibiotics before blood collection may significantly affect the recovery of bacterial pathogens from pediatric blood cultures in BacT/Alert Virtuo or Bactec FX BC systems, which remain the common techniques to diagnose bacteremia in pediatric patients. We simulated pediatric blood cultures with low or intermediate bacteremia level to evaluate BacT/Alert PF Plus and Bactec Peds Plus blood culture bottles for resin-based inactivation of 16 antibiotic–bacterium combinations. Overall, 105/192 (54.7%) of BacT/Alert PF Plus bottles and 69/192 (36.0%) of Bactec Peds Plus bottles allowed organisms to grow when exposed to antibiotics. In particular, both BacT/Alert PF Plus and Bactec Peds Plus bottles proved to be effective with piperacillin/tazobactam and Pseudomonas aeruginosa or with oxacillin and methicillin-susceptible Staphylococcus aureus (100% growth), whereas no effectiveness was apparent with ceftriaxone and Escherichia coli, Streptococcus agalactiae, or Streptococcus pneumoniae or with cefepime and E. coli (0% growth). In some relevant instances (e.g., with vancomycin and methicillin-resistant S. aureus or Streptococcus pneumoniae), BacT/Alert PF Plus bottles were superior to Bactec Peds Plus bottles. Together, these findings underscore the potentiality of resin-containing bottles to enhance diagnosis of bacteremia in pediatric patients on antimicrobial therapy. This is particularly true with one of the evaluated BC systems and with simulated intermediate bacteremia level only.

Published
2021

4. Re-evaluating positive serum samples for SARS-CoV-2-specific IgA and IgG antibodies using an in-house serological assay

Author

Cacaci, Margherita, Menchinelli, Giulia, Ricci, Rosalba, De Maio, Flavio, Mariotti, Melinda, Torelli, Riccardo, Morandotti, Grazia Angela, Bugli, Francesca, Sanguinetti, Maurizio, Posteraro, Brunella, Cacaci M. (ORCID:0000-0002-5433-9400), Menchinelli G., Ricci R., De Maio F., Mariotti M., Torelli R., Morandotti G. A., Bugli F. (ORCID:0000-0001-9038-3233), Sanguinetti M. (ORCID:0000-0002-9780-7059), Posteraro B. (ORCID:0000-0002-1663-7546), Cacaci, Margherita, Menchinelli, Giulia, Ricci, Rosalba, De Maio, Flavio, Mariotti, Melinda, Torelli, Riccardo, Morandotti, Grazia Angela, Bugli, Francesca, Sanguinetti, Maurizio, Posteraro, Brunella, Cacaci M. (ORCID:0000-0002-5433-9400), Menchinelli G., Ricci R., De Maio F., Mariotti M., Torelli R., Morandotti G. A., Bugli F. (ORCID:0000-0001-9038-3233), Sanguinetti M. (ORCID:0000-0002-9780-7059), and Posteraro B. (ORCID:0000-0002-1663-7546)

Abstract

Not available

Published
2021

5. Bordetella pertussis DNA detected in a tracheostomized child blood before seroconversion

Author

Liotti, Flora Marzia, De Angelis, Giulia, Speziale, Domenico, Morandotti, Grazia Angela, Genovese, Orazio, Sanguinetti, Maurizio, Posteraro, Brunella, Liotti F. M., De Angelis G. (ORCID:0000-0002-7087-7399), Speziale D., Morandotti G. A., Genovese O., Sanguinetti M. (ORCID:0000-0002-9780-7059), Posteraro B. (ORCID:0000-0002-1663-7546), Liotti, Flora Marzia, De Angelis, Giulia, Speziale, Domenico, Morandotti, Grazia Angela, Genovese, Orazio, Sanguinetti, Maurizio, Posteraro, Brunella, Liotti F. M., De Angelis G. (ORCID:0000-0002-7087-7399), Speziale D., Morandotti G. A., Genovese O., Sanguinetti M. (ORCID:0000-0002-9780-7059), and Posteraro B. (ORCID:0000-0002-1663-7546)

Abstract

NA

Published
2021

6. Prevalence and Clonal Distribution of Azole-Resistant Candida parapsilosis Isolates Causing Bloodstream Infections in a Large Italian Hospital

Author

Martini, Cecilia, Torelli, Riccardo, de Groot, T., De Carolis, Elena, Morandotti, Grazia Angela, De Angelis, Giulia, Posteraro, Brunella, Meis, J. F., Sanguinetti, Maurizio, Martini C., Torelli R., De Carolis E. (ORCID:0000-0003-4757-7256), Morandotti G. A., De Angelis G. (ORCID:0000-0002-7087-7399), Posteraro B. (ORCID:0000-0002-1663-7546), Sanguinetti M. (ORCID:0000-0002-9780-7059), Martini, Cecilia, Torelli, Riccardo, de Groot, T., De Carolis, Elena, Morandotti, Grazia Angela, De Angelis, Giulia, Posteraro, Brunella, Meis, J. F., Sanguinetti, Maurizio, Martini C., Torelli R., De Carolis E. (ORCID:0000-0003-4757-7256), Morandotti G. A., De Angelis G. (ORCID:0000-0002-7087-7399), Posteraro B. (ORCID:0000-0002-1663-7546), and Sanguinetti M. (ORCID:0000-0002-9780-7059)

Abstract

The most prevalent cause of nosocomial bloodstream infection (BSI) among non-C. albicans Candida species, Candida parapsilosis, may not only be resistant to azole antifungal agents but also disseminate to vulnerable patients. In this survey of BSIs occurring at a large Italian hospital between May 2014 and May 2019, C. parapsilosis accounted for 28.5% (241/844) of all Candida isolates causing BSI episodes. The majority of episodes (151/844) occurred in medical wards. Across the 5 yearly periods, the rates of azole non-susceptibility were 11.8% (4/34), 17.8% (8/45), 28.6% (12/42), 32.8% (19/58), and 17.7% (11/62), respectively, using the Sensititre YeastOne® method. Among azole non-susceptible isolates (54/241; 22.4%), 49 were available for further investigation. Using the CLSI reference method, all 49 isolates were resistant to fluconazole and, except one (susceptible dose-dependent), to voriconazole. Forty (81.6%) isolates harbored the Erg11p Y132F substitution and nine (18.4%) isolates the Y132F in combination with the Erg11p R398I substitution. According to their genotypes, as defined using a microsatellite analysis based on six short tandem repeat markers, 87.7% of isolates (43/49) grouped in two major clusters (II and III), whereas 4.1% of isolates (2/49) belonged to a separate cluster (I). Interestingly, all the isolates from cluster II harbored the Y132F substitution, and those from cluster III harbored both Y132F and R398I substitutions. Of 56 non-Italian isolates included as controls, two Indian isolates with the Y132F substitution had a genotype clearly differing from that of the isolates from clusters II and I. In conclusion, these findings show the dominance of clonal Y132F isolates in our hospital and suggest detection of the Y132F substitution as helpful tool to prevent transmission among hospitalized patients at risk of BSI.

Published
2020

7. Clinical microbiology laboratory adaptation to COVID-19 emergency: experience at a large teaching hospital in Rome, Italy

Author

Posteraro, Brunella, Marchetti, Simona, Romano, Lucio, Santangelo, Rosaria, Morandotti, Grazia Angela, Sanguinetti, Maurizio, Cattani Franchi, Paola, Posteraro B. (ORCID:0000-0002-1663-7546), Marchetti S., Romano L., Santangelo R. (ORCID:0000-0002-8056-218X), Morandotti G. A., Sanguinetti M. (ORCID:0000-0002-9780-7059), Cattani P. (ORCID:0000-0003-4678-4763), Posteraro, Brunella, Marchetti, Simona, Romano, Lucio, Santangelo, Rosaria, Morandotti, Grazia Angela, Sanguinetti, Maurizio, Cattani Franchi, Paola, Posteraro B. (ORCID:0000-0002-1663-7546), Marchetti S., Romano L., Santangelo R. (ORCID:0000-0002-8056-218X), Morandotti G. A., Sanguinetti M. (ORCID:0000-0002-9780-7059), and Cattani P. (ORCID:0000-0003-4678-4763)

Abstract

No abstract

Published
2020

13. MEN 10700, a new penem antibiotic: in-vitro activity and its correlation with beta-lactamase stability, PBP affinity and diffusion through the bacterial cell wall.

Author

Fontana, R, Altamura, M, Arcamone, F, Mazzariol, A, Morandotti, G, Sperning, R, and Cornaglia, G

Abstract

The in-vitro activity of MEN 10700, a novel penem, was compared with that of imipenem, ritipenem, ampicillin/sulbactam, cefotaxime, ciprofloxacin and amikacin against 1088 strains taken from 21 genera, including Gram-negative, Gram-positive and anaerobic bacteria. MIC data showed that MEN 10700 was very active against staphylococci and streptococci (MIC90 < or = 0.5 mg/L) and against most members of the Enterobacteriaceae (MIC90 < or = 2 mg/L), with reduced activity only against Providencia stuartii (MIC90 = 8 mg/L). MEN 10700 was also active against anaerobic species such as Clostridium perfringens and Bacteroides fragilis as well as Moraxella catarrhalis. It was moderately active against Enterococcus faecalis and inactive against Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Aeromonas spp. and Acinetobacter spp. Its antibacterial spectrum was thus slightly narrower than that of imipenem, but compared favourably with those of a third-generation cephalosporin and ritipenem. MEN 10700 was highly stable to a number of beta-lactamases and was a poor inducer of class I enzymes. It bound penicillin-binding protein 2 with the highest affinity and easily permeated the outer membrane of Escherichia coli. [ABSTRACT FROM AUTHOR]

Published
1998
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14. Original articles. MEN 10700, a new penem antibiotic: in-vitro activity and its correlation with β-lactamase stability, PBP affinity and diffusion through the bacterial cell wall.

Author

Fontana, R, Altamura, M, Arcamone, F, Mazzariol, A, Morandotti, G, Sperning, R, and Cornaglia, G

Abstract

The in-vitro activity of MEN 10700, a novel penem, was compared with that of imipenem, ritipenem, ampicillin/sulbactam, cefotaxime, ciprofloxacin and amikacin against 1088 strains taken from 21 genera, including Gram negative, Gram-positive and anaerobic bacteria. MIC data showed that MEN 10700 was very active against staphylococci and streptococci (MIC90≤0.5 mg/L) and against most members of the Enterobacteriaceae (MIC90≤2 mg/L), with reduced activity only against Providencia stuartii (MIC90=8 mg/L). MEN 10700 was also active against anaerobic species such as Clostridium perfringens and Bacteroides fragilis as well as Moraxella catarrhalis. It was moderately active against Enterococcus faecalis and inactive against Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Aeromonas spp. and Acinetobacter spp. Its antibacterial spectrum was thus slightly narrower than that of imipenem, but compared favourably with those of a third-generation cephalosporin and ritipenem. MEN 10700 was highly stable to a number of β-lactamases and was a poor inducer of class I enzymes. It bound penicillin-binding protein 2 with the highest affinity and easily permeated the outer membrane of Escherichia coli. [ABSTRACT FROM PUBLISHER]

Published
1998
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18. Gaetano Gandolfi, Allegoria del sacramento del Battesimo

Author

BIAGI, DONATELLA, M. Agostini, D. Benati, D. Biagi Maino, A. Brogi, G. Del Monaco, P. Di Natale, F. Frangi, F. Giannini, A. Morandotti, G. Palloni, F. Massaccesi, M. Riccomini, E. Sambo, Daniele Benati, and Donatella Biagi Maino

Subjects
ITALIA DEL SETTECENTO, AUFKLÄRUNG, SACRAMENTO, PITTURA
Abstract

La raffigurazione dei Sacramenti nel XVIII secolo acquista sempre più rilevante importanza anche in quel clima di riformismo che anima le coscienze più ricettive e libere dagli opposti estremismi che contrappongono, dallo scadere del secolo precedente, regolata devozione e convinto rigorismo. La scelta di impaginare l'immagine del primo tra i Sacramenti in termini di affabile quanto severa, nel rispetto del dettato religioso, rappresentazione dimostra quanto del lascito benedettino sia impellente, ancora nella seconda metà del Settecento, all'immaginazione del Gandolfi, che stempera l'austerità del racconto - al sommo la presenza dell'Agnello è di non poco momento - con la trama di una pittura morbidamente condotta nell'adozione del colore euilibratissimo nei toni e nelle modalità di stesura.

Published
2013

19. Clinical microbiology laboratory adaptation to COVID-19 emergency: experience at a large teaching hospital in Rome, Italy.

Author

Posteraro B, Marchetti S, Romano L, Santangelo R, Morandotti GA, Sanguinetti M, and Cattani P

Subjects
COVID-19, Hospitals, Teaching, Humans, Laboratories, Hospital, Pandemics, Real-Time Polymerase Chain Reaction, Rome, SARS-CoV-2, Betacoronavirus isolation & purification, Coronavirus Infections diagnosis, Pneumonia, Viral diagnosis
Published
2020
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