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1. Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimers disease.

Author

Agra Almeida Quadros, Ana, Li, Zhaozhi, Wang, Xue, Ndayambaje, I, Aryal, Sandeep, Ramesh, Nandini, Nolan, Matthew, Jayakumar, Rojashree, Han, Yi, Stillman, Hannah, Aguilar, Corey, Wheeler, Hayden, Connors, Theresa, Lopez-Erauskin, Jone, Baughn, Michael, Melamed, Zeev, Beccari, Melinda, Olmedo Martínez, Laura, Canori, Michael, Lee, Chao-Zong, Moran, Laura, Draper, Isabelle, Kopin, Alan, Oakley, Derek, Dickson, Dennis, Cleveland, Don, Hyman, Bradley, Das, Sudeshna, Ertekin-Taner, Nilüfer, and Lagier-Tourenne, Clotilde

Subjects
Alzheimer’s disease, Cryptic exons, SCG-10, Stathmin-2, TARDBP, TDP-43, UNC13A, Humans, Alzheimer Disease, Amyotrophic Lateral Sclerosis, DNA-Binding Proteins, Frontotemporal Dementia, Pick Disease of the Brain, RNA Splicing, RNA, Messenger, Stathmin
Abstract

Nuclear clearance and cytoplasmic accumulations of the RNA-binding protein TDP-43 are pathological hallmarks in almost all patients with amyotrophic lateral sclerosis (ALS) and up to 50% of patients with frontotemporal dementia (FTD) and Alzheimers disease. In Alzheimers disease, TDP-43 pathology is predominantly observed in the limbic system and correlates with cognitive decline and reduced hippocampal volume. Disruption of nuclear TDP-43 function leads to abnormal RNA splicing and incorporation of erroneous cryptic exons in numerous transcripts including Stathmin-2 (STMN2, also known as SCG10) and UNC13A, recently reported in tissues from patients with ALS and FTD. Here, we identify both STMN2 and UNC13A cryptic exons in Alzheimers disease patients, that correlate with TDP-43 pathology burden, but not with amyloid-β or tau deposits. We also demonstrate that processing of the STMN2 pre-mRNA is more sensitive to TDP-43 loss of function than UNC13A. In addition, full-length RNAs encoding STMN2 and UNC13A are suppressed in large RNA-seq datasets generated from Alzheimers disease post-mortem brain tissue. Collectively, these results open exciting new avenues to use STMN2 and UNC13A as potential therapeutic targets in a broad range of neurodegenerative conditions with TDP-43 proteinopathy including Alzheimers disease.

Published
2024

6. Immune checkpoint inhibitors-associated thrombosis in patients with lung cancer and melanoma: a study of the Spanish society of medical oncology (SEOM) thrombosis and cancer group

Author

Cánovas, Manuel Sánchez, Garay, David Fernández, Moran, Laura Ortega, Pérez, Jaime Rubio, Rubio, Carlos Miguel Guirao, de Mena, Miriam Lobo, Portero, Berta Obispo, Castro, Jesús Brenes, Lage, Yolanda, Lavin, Diego Cacho, Blanco, Ana Belen Rupérez, de Soignie, Ana Manuela Martín Fernández, Perejón, Jonatan Zacarías Benoit, Colomo, Laura Jiménez, Boluda, Noel Blaya, Moreno, Javier Bosque, Verduguez, Teresa Quintanar, Garrido, Carmen Rosa, Huertas, Roberto Martín, Puig, Carme Font i, and Martín, Andrés Jesús Muñoz

Published
2022
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9. Notes

Author

Moran, Laura

14. Index

Author

Moran, Laura

17. Cover

Author

Moran, Laura

25. Incidence, risk factors, and evolution of venous thromboembolic events in patients diagnosed with pancreatic carcinoma and treated with chemotherapy on an outpatient basis

Author

García Adrián, Silvia, González, Adán Rodríguez, de Castro, Eva Martínez, Olmos, Vanessa Pachón, Morán, Laura Ortega, del Prado, Purificación Martínez, Fernández, Mercedes Salgado, Burón, José David Cumplido, Escobar, Ignacio García, Galán, Joaquina Martínez, Pérez, Ana Isabel Ferrer, Neria, Fernando, Lavin, Diego Cacho, Hernández, Borja López de San Vicente, Jiménez-Fonseca, Paula, and Muñoz Martín, Andrés J.

Published
2022
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26. coMpliAnce with evideNce-based cliniCal guidelines in the managemenT of acute biliaRy pancreAtitis): The MANCTRA-1 international audit

Author

Podda, Mauro, Gerardi, Chiara, Coccolini, Federico, di Saverio, Salomone, Pellino, Gianluca, Pata, Francesco, Ielpo, Benedetto, Virdis, Francesco, Damaskos, Dimitris, Gourgiotis, Stavros, Poillucci, Gaetano, Pacella, Daniela, Jayant, Kumar, Agresta, Ferdinando, Sartelli, Massimo, Leppaniemi, Ari, Riboni, Cristiana, Catena, Fausto, Kluger, Yoram, Pisanu, Adolfo, Giordano, Alessio, Ferrario, Luca, Calvo, Mikel Prieto, Wilson, Michael, Soggiu, Fiammetta, Hamdan, Alaa, Gomes, Carlos Augusto, Fraga, Gustavo, Ioannidis, Argyrios, De Simone, Belinda, Demetrashvili, Zaza, Sahani, Saaz, Bains, Lovenish, Khamees, Almu'atasim, Ababneh, Hazim, Aljaiuossi, Osama, Pimentel, Samuel, Mohamad, Ikhwan Sani, Yusoff, Ahmad Ramzi, Zarnescu, Narcis Octavian, Calu, Valentin, Litvin, Andrey, Lesko, Dusan, Elmehrath, Ahmed, Elshami, Mohamedraed, de Santibañes, Martin, Gundara, Justin, Alawadhi, Kamel, Lui, Rashid, Julianov, Alexander, Ralon, Sergio, Garzali, Ibrahim-Umar, Machain, Gustavo M., Quispe-Cruz, Darwin Artidoro, Orantia, Abigail Cheska C., Walędziak, Maciej, Correia de Sá, Tiago, Ali, Syed Muhammad, Kovacevic, Bojan, Noel, Colin, Abdalah, Haidar M., Kchaou, Ali, Isik, Arda, Ansaloni, Luca, Biffl, Walter, Guerrieri, Mario, Sartori, Alberto, Abradelo, Manuel, Nigri, Giuseppe, Di Lorenzo, Nicola, Mingoli, Andrea, Chiarugi, Massimo, Di Menno Stavron, Juliana, Mazza, Oscar, Valenzuela, José Ignacio, Pantoja Pachajoa, Diana Alejandra, Alvarez, Fernando Andrés, Liaño, Julian Ezequiel, Tefay, Joan, Alshaikh, Abdulrahman, Hasan, Layla, Augusto Gomes, Carlos, Gomes, Felipe Couto, Fraga, Gustavo P., Calderan, Thiago R.A., Hirano, Elcio S., Dardanov, Dragomir, Saroglu, Azize, Atanasov, Boyko, Belev, Nikolay, Kovachev, Nikola, Chan, Shannon Melissa, Lok, Hon-Ting, Salcedo, Diego, Robayo, Diana, Triviño, María Alejandra, Manak, Jan, de Araujo, Jorann, Sethi, Ananya, Awad, Ahmed, Elbadawy, Merihan, Farid, Ahmed, Hanafy, Asmaa, Nafea, Ahmed, Sherief-Ghozy, Salah – Abbas, Alzhraa, Abdelsalam, Wafaa, Emile, Sameh, Elfallal, Ahmed, Elfeki, Hossam, Elghadban, Hosam, Shoma, Ashraf, Shetiwy, Mohamed, Elbahnasawy, Mohamed, Mohamed, Salem, Hamed, Emad Fawzi, Khalil, Usama Ahmed, Chouillard, Elie, Gumbs, Andrew, Police, Andréa, Mabilia, Andrea, Khutsishvili, Kakhi, Tvaladze, Anano, Ioannidis, Orestis, Anestiadou, Elissavet, Loutzidou, Lydia, Konstantinidis, Konstantinis, Konstantinidou, Sofia, Manatakis, Dimitrios, Acheimastos, Vasileios, Tasis, Nikolaos, Michalopoulos, Nikolaos, Kokoropoulos, Panagiotis, Papadoliopoulou, Maria, Sotiropoulou, Maria, Kapiris, Stylianos, Metaxas, Panagiotis, Tsouknidas, Ioannis, Kefili, Despoina, Petrakis, George, Dakis, Konstantinos, Alexandridou, Eirini, Synekidou, Eirini, Dakis, Kostas, Papadopoulos, Aristeidis, Chouliaras, Christos, Mouzakis, Odysseas, Mulita, Francesk, Maroulis, Ioannis, Vailas, Michail, Triantafyllou, Tania, Theodorou, Dimitrios, Lostoridis, Eftychios, Nagorni, Eleni-Aikaterini, Tourountzi, Paraskevi, Baili, Efstratia, Charalabopoulos, Alexandros, Liakakos, Theodore, Schizas, Dimitrios, Kozadinos, Alexandros, Syllaios, Athanasios, Machairas, Nikolaos, Kykalos, Stylianos, Stamopoulos, Paraskevas, Delis, Spiros, Farazi-Chongouki, Christos, Kalaitzakis, Evangelos, Giannarakis, Miltiadis, Lasithiotakis, Konstantinos, Petra, Giorgia, Gupta, Amit, Medappil, Noushif, Muthukrishnan, Vijayanand, Kamar, Jubin, Lal, Pawan, Agarwal, Rajendra, Magnoli, Matteo, Aonzo, Paolo, Serventi, Alberto, Giuliani, Antonio, Di Lascio, Pierpaolo, Pinto, Margherita, Bergamini, Carlo, Bottari, Andrea, Fortuna, Laura, Martellucci, Jacopo, Cicako, Atea, Miglietta, Claudio, Morino, Mario, Delogu, Daniele, Picchetto, Andrea, Assenza, Marco, D'Ambrosio, Giancarlo, Argenio, Giulio, Armellino, Mariano Fortunato, Ioia, Giovanna, Occhionorelli, Savino, Andreotti, Dario, Domenico, Lacavalla, Luppi, Davide, Casadei, Massimiliano, Di Donato, Luca, Manoochehri, Farshad, Lucia Marchese, Tiziana Rita, Sergi, William, Manca, Roberto, Murgia, Raimondo, Piras, Enrico, Conti, Lorenzo, Gianazza, Simone, Rizzi, Andrea, Segalini, Edoardo, Monti, Marco, Iiritano, Elena, Mariani, Nicolò Maria, De Nicola, Enrico, Scifo, Giovanna, Pignata, Giusto, Andreuccetti, Jacopo, Fleres, Francesco, Clarizia, Guglielmo, Spolini, Alessandro, Biloslavo, Alan, Germani, Paola, Mastronardi, Manuela, Bogoni, Selene, Palmisano, Silvia, De Manzini, Nicolo’, Marino, Marco Vito, Martines, Gennaro, Trigiante, Giuseppe, Lagouvardou, Elpiniki, Anania, Gabriele, Bombardini, Cristina, Oppici, Dario, Pilia, Tiziana, Murzi, Valentina, Gessa, Emanuela, Bracale, Umberto, Di Nuzzo, Maria Michela, Peltrini, Roberto, Salvetti, Francesco, Viganò, Jacopo, Sganga, Gabriele, Bianchi, Valentina, Fransvea, Pietro, Fontana, Tommaso, Sarro, Giuliano, Dinuzzi, Vincenza Paola, Scaravilli, Luca, Papa, Mario Virgilio, Jovine, Elio, Ciabatti, Giulia, Mastrangelo, Laura, Rottoli, Matteo, Ricci, Claudio, Russo, Iris Shari, Aiolfi, Alberto, Bona, Davide, Lombardo, Francesca, Cianci, Pasquale, Bini, Roberto, Chiara, Osvaldo, Cioffi, Stefano, Cantafio, Stefano, Coretti, Guido, Licitra, Edelweiss, Savino, Grazia, Grimaldi, Sergio, Porfidia, Raffaele, Moggia, Elisabetta, Garino, Mauro, Marafante, Chiara, Pesce, Antonio, Fabbri, Nicolò, Feo, Carlo Vittorio, Marra, Ester, Troian, Marina, Drigo, Davide, Nagliati, Carlo, Andrea, Muratore, Danna, Riccardo, Murgese, Alessandra, Crespi, Michele, Guerci, Claudio, Frontali, Alice, Ferrari, Luca, Favi, Francesco, Picariello, Erika, Rampini, Alessia, D'Acapito, Fabrizio, Ercolani, Giorgio, Solaini, Leonardo, Palmieri, Francesco, Calì, Matteo, Ferrara, Francesco, Muttillo, Irnerio Angelo, Muttillo, Edoardo Maria, Picardi, Biagio, Galleano, Raffaele, Badran, Ali, Ghazouani, Omar, Cervellera, Maurizio, Campanella, Gaetano, Papa, Gennaro, Di Bella, Annamaria, Perrone, Gennaro, Petracca, Gabriele Luciano, Prioriello, Concetta, Giuffrida, Mario, Cozzani, Federico, Rossini, Matteo, Inama, Marco, Butturini, Giovanni, Moretto, Gianluigi, Morelli, Luca, Di Candio, Giulio, Guadagni, Simone, Cicuttin, Enrico, Cremonini, Camilla, Tartaglia, Dario, Genovese, Valerio, Cillara, Nicola, Cannavera, Alessandro, Deserra, Antonello, Picciariello, Arcangelo, Papagni, Vincenzo, Vincenti, Leonardo, Bagaglini, Giulia, Sica, Giuseppe, Lapolla, Pierfrancesco, Brachini, Gioia, Bono, Dario, Nicotera, Antonella, Zago, Marcello, Sammartano, Fabrizio, Benuzzi, Laura, Stella, Marco, Rossi, Stefano, Cerioli, Alessandra, Puccioni, Caterina, Olmi, Stefano, Rubicondo, Carolina, Uccelli, Matteo, Balla, Andrea, Guida, Anna, Lepiane, Pasquale, Sasia, Diego, Giraudo, Giorgio, Salomone, Sara, Belloni, Elena, Cossa, Alessandra, Lancellotti, Francesco, Caronna, Roberto, Chirletti, Piero, Saullo, Paolina, Troiano, Raffaele, Mucilli, Felice, Barone, Mirko, Ippoliti, Massimo, Grande, Michele, Sensi, Bruno, Siragusa, Leandro, Ortenzi, Monica, Santini, Andrea, Di Carlo, Isidoro, Veroux, Massimiliano, Gioco, Rossella, Veroux, Gastone, Currò, Giuseppe, Ammendola, Michele, Komaei, Iman, Navarra, Giuseppe, Tonini, Valeria, Sartarelli, Lodovico, Vaccari, Samuele, Ceresoli, Marco, Perrone, Stefano, Roccamatisi, Linda, Millo, Paolo, Contul, Riccardo Brachet, Ponte, Elisa, Zuin, Matteo, Portale, Giuseppe, Tonello, Alice Sabrina, Fratini, Geri, Bianchini, Matteo, Perotti, Bruno, Doria, Emanuele, Lunghi, Elia Giuseppe, Visconti, Diego, Al-Shami, Khayry, Awadi, Sajeda, Khalil Buwaitel, Mohammad Musallam, Naief Naffa', Mo'taz Fawzat, Samhouri, Ahmad, Sawalha, Hatem, Ramzi Yusoff, Ahmad, Che Ani, Mohd Firdaus, Ahmed Fathil, Ida Nadiah, Huei, Jih, Zakaria, Andee Dzulkarnaen, Ya'acob, Mohammad Zawawi, Beristain-Hernandez, Jose-Luis, Garcia-Meza, Alejandro, Sepulveda-Rdriguez, Rafael, Lozada Hernández, Edgard Efren, Acuña Pinzón, Camilo Levi, Condoy, Jefferson Nieves, Becerra García, Francisco C., Sadik, Mohammad, Jalpa, kadir, Bushra, Devi, Jalpa, Seerani, Nandlal, Zainab, Asghar, Mohammad Sohail, Afzal, Ameer, Akbar, Ali, Lohse, Helmut Segovia, Lohse, Herald Segovia, Artidoro Quispe-Cruz, Darwin, Leon Cabrera, Zamiara Solange, Yamamoto Seto, Gaby Susana, Chiuyari, José Ríos, Ordemar, Jorge, Rodríguez, Martha, Orantia-Carlos, Abigail Cheska C., Quitoy, Margie Antionette, Kwiatkowski, Andrzej, Mawlichanów, Maciej, Rocha, Mónica, Soares, Carlos, Muhammad Ali, Syed, Stoian, Alexandru Rares, Diana Draghici, Andreea, Draghici, Andreea Diana, Grigorean, Valentin Titus, Radulescu, Raluca Bievel, Costea, Radu Virgil, Zarnescu, Eugenia Claudia, Kurtenkov, Mikhail, Gendrikson, George, Alla-Angelina, Volovich, Arina, Tsurbanova, Kaldarov, Ayrat, Gachabayov, Mahir, Abdullaev, Abakar, Milentijevic, Milica, Karamarkovic, Milovan, Panyko, Arpád, Radonak, Jozef, Soltes, Marek, Álvarez Morán, Laura, García, Haydée Calvo, Vega, Pilar Suárez, Estevez, Sergio, Ausania, Fabio, Farguell, Jordi, González-Abós, Carolina, Sánchez-Cabús, Santiago, Martín, Belén, Molina, Víctor, Oms, Luis, Ilzarbe, Lucas, Feijóo, Eva Pont, Perra, Elena Sofia, Rojas-Bonet, Noel, Penalba-Palmí, Rafael, Pérez-Bru, Susana, Tur-Martínez, Jaume, Álvarez-Torrado, Andrea, Domingo-Gonzalez, Marta, Tejedor-Tejada, Javier, Di Martino, Marcello, García del Alamo, Yaiza, Mendoza-Moreno, Fernando, García-Moreno-Nisa, Francisca, Matías-García, Belén, Durán, Manuel, Calleja-Lozano, Rafael, Perez de Villar, José Manuel, Sánchez-Guillén, Luis, Caravaca, Iban, Triguero-Cánovas, Daniel, Maya Aparicio, Antonio Carlos, Meléndez, Blas Durán, Palacios, Andrea Masiá, Landaluce-olavarria, Aitor, De Francisco, Mario, Estraviz-Mateos, Begoña, Alconchel, Felipe, Nicolás-López, Tatiana, Ramírez, Pablo, Muñoz-Cruzado, Virginia Duran, Ciuró, Felipe Pareja, Perea del Pozo, Eduardo, Pizarro, Sergio Olivares, Cabrera, Vicente Herrera, Bayo, Jose Muros, Hamid, Hytham K.S., Roesel, Raffaello, Cristaudi, Alessandra, Abbas, Kinan, Ali, Iyad, Tlili, Ahmed, Bayhan, Hüseyin, Türkoğlu, Mehmet Akif, Uzunoglu, Mustafa Yener, Azamat, Ibrahim Fethi, Omarov, Nail, Uymaz, Derya Salim, Altintoprak, Fatih, Akin, Emrah, First, Necattin, Das, Koray, Ozer, Nazmi, Seker, Ahmet, Kara, Yasin, Bozkurt, Mehmet Abdussamet, Kocataş, Ali, Atici, Semra Demirli, Akalin, Murat, Calik, Bulent, Colak, Elif, Altinel, Yuksel, Meric, Serhat, Aktimur, Yunus Emre, Hudson, Victoria, Duval, Jean-Luc, Khan, Mansoor, Saad, Ahmed, Kaur, Mandeep, Bradley, Alison, Fox, Katherine, Tomasi, Ivan, Beasley, Daniel, Prasanti, Alekhya Kotta, Kotecha, Pinky, Ebied, Husam, Paul, Michaela, Sheth, Hemant, Gerogiannis, Ioannis, Gaber, Mohannad, Sheikh, Zara, Seth, Shatadru, Kunitsyna, Maria, Leo, Cosimo Alex, Bellato, Vittoria, Zafar, Noman, Elserafy, Amr, Bond-smith, Giles, Tebala, Giovanni, Mathur, Pawan, Abid, Izza, Chidumije, Nnaemeka, Sandhar, Pardip, Zohaib Ullah, Syed Osama, Lezama, Tamara, Anwaar, Muhammad Hassan, Magee, Conor, Ahmed, Salma, Davies, Brooke, Apollos, Jeyakumar, McCormack, Kieran, Choudhary, Hasham, Doulias, Triantafyllos, Morrison, Tamsin, Palepa, Anna, Cal, Fernando Bonilla, Sánchez, Lianet, Domínguez, Fabiana, Al-Raimi, Ibrahim, Alshargabi, Haneen, Meead, Abdullah, Di Saverio, Salomone, Damaskos, Dimitrios, Agnoletti, Vanni, and Mole, Damian

Published
2022
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28. High-Dose Isoniazid Lacks EARLY Bactericidal Activity against Isoniazid-resistant Tuberculosis Mediated by katG Mutations: A Randomized Phase II Clinical Trial.

Author

Gausi, Kamunkhwala, Ignatius, Elisa H., De Jager, Veronique, Upton, Caryn, Kim, Soyeon, McKhann, Ashley, Moran, Laura, Wiesner, Lubbe, von Groote-Bidlingmaier, Florian, Marzinek, Philip, Vanker, Naadira, Yvetot, Joseph, Pierre, Samuel, Rosenkranz, Susan L., Swindells, Susan, Diacon, Andreas H., Nuermberger, Eric L., Denti, Paolo, and Dooley, Kelly E.

Subjects
ISONIAZID, MULTIDRUG-resistant tuberculosis, TUBERCULOSIS, CLINICAL trials, BACTERICIDAL action, MYCOBACTERIUM tuberculosis
Abstract

Rationale: Observational studies suggest that high-dose isoniazid may be efficacious in treating multidrug-resistant tuberculosis. However, its activity against Mycobacterium tuberculosis (M.tb) with katG mutations (which typically confer high-level resistance) is not established. Objectives: To characterize the early bactericidal activity (EBA) of high-dose isoniazid in patients with tuberculosis caused by katG-mutated M.tb. Methods: A5312 was a phase IIA randomized, open-label trial. Participants with tuberculosis caused by katG-mutated M.tb were randomized to receive 15 or 20 mg/kg isoniazid daily for 7 days. Daily sputum samples were collected for quantitative culture. Intensive pharmacokinetic sampling was performed on Day 6. Data were pooled across all A5312 participants for analysis (drug-sensitive, inhA-mutated, and katG-mutated M.tb). EBA was determined using nonlinear mixed-effects modeling. Measurements and Main Results: Of 80 treated participants, 21 had katG-mutated M.tb. Isoniazid pharmacokinetics were best described by a two-compartment model with an effect of NAT2 acetylator phenotype on clearance. Model-derived maximum concentration and area under the concentration–time curve in the 15 and 20 mg/kg groups were 15.0 and 22.1 mg/L and 57.6 and 76.8 mg ⋅ h/L, respectively. Isoniazid bacterial kill was described using an effect compartment and a sigmoidal maximum efficacy relationship. Isoniazid potency against katG-mutated M.tb was approximately 10-fold lower than in inhA-mutated M.tb. The highest dose of 20 mg/kg did not demonstrate measurable EBA, except against a subset of slow NAT2 acetylators (who experienced the highest concentrations). There were no grade 3 or higher drug-related adverse events. Conclusions: This study found negligible bactericidal activity of high-dose isoniazid (15–20 mg/kg) in the majority of participants with tuberculosis caused by katG-mutated M.tb. Clinical trial registered with (NCT01936831). [ABSTRACT FROM AUTHOR]

Published
2024
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29. Belonging and Becoming in a Multicultural World

Author

Moran, Laura

Subjects
Social Science, Emigration & Immigration, bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFN Migration, immigration & emigration
Abstract

Children and youth are front and center in the context of global mass migration and the social discord around questions of multicultural inclusion that it often ignites. It is young people at the forefront of navigating the complexities of cultural and ethnic diversity in their everyday lives. Imprecise portrayals of their inclination to either embrace diversity or to incite racism are used to exemplify both the success and failures of the multicultural project. In the context of young people’s heightened politicization, Belonging and Becoming in a Multicultural World, shifts the focus to a group of Sudanese and Karen refugee youth’s own insights, explanations and practices as they attempt to create a sense of identity and belonging. It sees these young people engaging race, racism and national identity in creative and unexpected ways as they are confronted with the social and moral implications of multiculturalism in Australia.

Published
2019

30. QT effects of bedaquiline, delamanid, or both in patients with rifampicin-resistant tuberculosis: a phase 2, open-label, randomised, controlled trial

Author

Alli, Oladapo, Gottesman, Joan, Guevara, Maria, Hikuam, Chris, Hovind, Laura, Karlsson, Mats, McClaren, Jennifer, McIlleron, Helen, Murtaugh, William, Rolls, Barbara, Shahkolahi, Akbar, Stone, Lynnett, Tegha, Gerald, Tenai, Jacob, Upton, Caryn, Wimbish, Chanelle, Dooley, Kelly E, Rosenkranz, Susan L, Conradie, Francesca, Moran, Laura, Hafner, Richard, von Groote-Bidlingmaier, Florian, Lama, Javier R., Shenje, Justin, De Los Rios, Jorge, Comins, Kyla, Morganroth, Joel, Diacon, Andreas H, Cramer, Yoninah S, Donahue, Kathleen, and Maartens, Gary

Published
2021
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31. A snapshot of cancer-associated thromboembolic disease in 2018–2019: First data from the TESEO prospective registry

Author

Carmona-Bayonas, Alberto, Gómez, David, Martínez de Castro, Eva, Pérez Segura, Pedro, Muñoz Langa, José, Jimenez-Fonseca, Paula, Sánchez Cánovas, Manuel, Ortega Moran, Laura, García Escobar, Ignacio, Rupérez Blanco, Ana Belén, Fernández Pérez, Isaura, Martínez de Prado, Purificación, Porta i Balanyà, Rut, Quintanar Verduguez, Teresa, Rodríguez-Lescure, Álvaro, and Muñoz, Andrés

Published
2020
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32. Prevalence and Correlates of Electrocardiographic Abnormalities in Adults With HIV: Insights From the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE)

Author

Bloomfield, Gerald S., Weir, Isabelle R., Ribaudo, Heather J., Fitch, Kathleen V., Fichtenbaum, Carl J., Moran, Laura E., Bedimo, Roger, de Filippi, Christopher, Morse, Caryn G., Piccini, Jonathan, Zanni, Markella V., Lu, Michael T., Hoffmann, Udo, Grinspoon, Steven K., and Douglas, Pamela S.

Published
2022
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33. Training Class Inclusion Responding in Typically Developing Children and Individuals with Autism

Author

Ming, Siri, Mulhern, Teresa, Stewart, Ian, Moran, Laura, and Bynum, Kellie

Abstract

In a "class inclusion" task, a child must respond to stimuli as being involved in two different though hierarchically related categories. This study used a Relational Frame Theory (RFT) paradigm to assess and train this ability in three typically developing preschoolers and three individuals with autism spectrum disorder, all of whom had failed class inclusion tests. For all subjects, relational training successfully established the target repertoire and subsequent testing demonstrated both maintenance and generalization. Limitations and future research directions are discussed.

Published
2018
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34. Antiretroviral therapy and vaginally administered contraceptive hormones: a three-arm, pharmacokinetic study

Author

Barr, Liz, Blanchard-Horan, Christina, Connick, Elizabeth, Cermak, Mary Allegra, Chakhtoura, Nahida, Chang-Ching, Cecelia, Fox, Andee, Haas, David W., Landay, Alan, Leon, Mey, Park, Jeong-Gun, Patterson, Kristine, Sise, Thucuma, Spear, Greg, Shugarts, David, Tshandu, Pamela, Wira, Charles R, Scarsi, Kimberly K, Cramer, Yoninah S, Rosenkranz, Susan L, Aweeka, Francesca, Berzins, Baiba, Coombs, Robert W, Coughlin, Kristine, Moran, Laura E, Zorrilla, Carmen D, Akelo, Victor, Aziz, Mariam, Friedman, Ruth K, Gingrich, David, Swaminathan, Shobha, Godfrey, Catherine, and Cohn, Susan E

Published
2019
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35. Adverse Pregnancy Outcomes Among Women with Human Immunodeficiency Virus Taking Isoniazid Preventive Therapy During the First Trimester.

Author

Gupta, Amita, Hughes, Michael D, Cruz, Jorge Leon, Avihingsanon, Anchalee, Mwelase, Noluthando, Severe, Patrice, Omoz-Oarhe, Ayotunde, Masheto, Gaerolwe, Moran, Laura, Benson, Constance A, Chaisson, Richard E, and Swindells, Susan

Subjects
TUBERCULOSIS prevention, ISONIAZID, SECONDARY analysis, ANTIRETROVIRAL agents, RESEARCH funding, PREMATURE infants, HIV infections, PREGNANCY outcomes, PREGNANT women, PERINATAL death, RELATIVE medical risk, DESCRIPTIVE statistics, LOW birth weight, FIRST trimester of pregnancy, CONFIDENCE intervals, REGRESSION analysis, PREGNANCY
Abstract

Background Isoniazid preventive therapy (IPT) is recommended for tuberculosis prevention yet data on the safety of first-trimester pregnancy exposure are limited. Methods Planned secondary analysis in a TB prevention trial of adverse pregnancy outcomes among participants assigned to 9-month IPT who became pregnant during (IPT-exposed) or after (unexposed) IPT. Regression models compared binary outcomes of a composite adverse outcome (any non-live birth, excluding induced abortion); preterm delivery <37 weeks; and low birth weight <2500 g) among exposure groups. Models were adjusted for latent TB infection, maternal age, CD4 count, and antiretroviral therapy (ART). Results In total, 128 participants had a known pregnancy outcome; 39 IPT-exposed and 89 unexposed. At pregnancy outcome, ART use was lower in IPT-exposed (79%) than unexposed women (98%). Overall, 29 pregnancies ended in a composite adverse outcome (25 spontaneous abortions, 2 stillbirths and 2 ectopic pregnancies), 15 preterm deliveries, and 10 infants with low birth weight. IPT was associated with the composite adverse outcome adjusting for covariates at enrollment (adjusted relative risk [aRR] 1.98; 95% confidence interval [CI] 1.15, 3.41), but the effect was attenuated when adjusted for covariates at pregnancy outcome (aRR 1.47; 95% CI.84, 2.55); IPT was not associated with preterm delivery (relative risk [RR] 0.87; 95% CI.32–2.42) or low birth weight (RR 1.01; 95% CI.29, 3.56). Conclusions First-trimester IPT exposure was associated with nearly two-fold increased risk of fetal demise, mostly spontaneous abortion, though the association was attenuated when adjusted for covariates proximal to pregnancy outcome including ART use. Further study is needed to inform TB prevention guidelines. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Adverse Pregnancy Outcomes among HIV-infected Women Taking Isoniazid Preventive Therapy During the First Trimester

Author

Gupta, Amita, primary, Hughes, Michael D, additional, Cruz, Jorge Leon, additional, Avihingsanon, Anchalee, additional, Mwelase, Noluthando, additional, Severe, Patrice, additional, Omoz-Oarhe, Ayotunde, additional, Masheto, Gaerolwe, additional, Moran, Laura, additional, Benson, Constance A, additional, Chaisson, Richard E, additional, and Swindells, Susan, additional

Published
2023
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37. Efficacy and Safety of Three Antiretroviral Regimens for Initial Treatment of HIV-1: A Randomized Clinical Trial in Diverse Multinational Settings

Author

Campbell, Thomas B, Smeaton, Laura M, Kumarasamy, N, Flanigan, Timothy, Klingman, Karin L, Firnhaber, Cynthia, Grinsztejn, Beatriz, Hosseinipour, Mina C, Kumwenda, Johnstone, Lalloo, Umesh, Riviere, Cynthia, Sanchez, Jorge, Melo, Marineide, Supparatpinyo, Khuanchai, Tripathy, Srikanth, Martinez, Ana I, Nair, Apsara, Walawander, Ann, Moran, Laura, Chen, Yun, Snowden, Wendy, Rooney, James F, Uy, Jonathan, Schooley, Robert T, De Gruttola, Victor, Hakim, James Gita, Swann, Edith, Barnett, Ronald L, Brizz, Barbara, Delph, Yvette, Gettinger, Nikki, Mitsuyasu, Ronald T, Eshleman, Susan, Safren, Steven, Fiscus, Susan A, Andrade, Adriana, Haas, David W, Amod, Farida, Berthaud, Vladimir, Bollinger, Robert C, Bryson, Yvonne, Celentano, David, Chilongozi, David, Cohen, Myron, Collier, Ann C, Currier, Judith Silverstein, Cu-Uvin, Susan, Eron, Joseph, Flexner, Charles, Gallant, Joel E, Gulick, Roy M, Hammer, Scott M, Hoffman, Irving, Kazembe, Peter, Kumwenda, Newton, Lama, Javier R, Lawrence, Jody, Maponga, Chiedza, Martinson, Francis, Mayer, Kenneth, Nielsen, Karin, Pendame, Richard B, Ramratnam, Bharat, Sanne, Ian, Severe, Patrice, Sirisanthana, Thira, Solomon, Suniti, Tabet, Steve, Taha, Taha, van der Horst, Charles, Wanke, Christine, Gormley, Joan, Marcus, Cheryl J, Putnam, Beverly, Loeliger, Edde, Pappa, Keith A, Webb, Nancy, Shugarts, David L, Winters, Mark A, Descallar, Renard S, Steele, Joseph, Wulfsohn, Michael, Said, Farideh, Chen, Yue, Martin, John C, Bischofberger, Norbert, Cheng, Andrew, Jaffe, Howard, Sharma, Jabin, Poongulali, S, Cardoso, Sandra Wagner, Faria, Deise Lucia, Berendes, Sima, Burke, Kelly, Mngqibisa, Rosie, Kanyama, Cecelia, Kayoyo, Virginia, Samaneka, Wadzanai P, Chisada, Anthony, and Faesen, Sharla

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Patient Safety, Infectious Diseases, Comparative Effectiveness Research, HIV/AIDS, Clinical Trials and Supportive Activities, Clinical Research, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Infection, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, Coinfection, Drug Therapy, Combination, Female, Follow-Up Studies, HIV Infections, HIV-1, Humans, Internationality, Male, Mycobacterium tuberculosis, Pregnancy, Time Factors, Treatment Outcome, Withholding Treatment, PEARLS study team of the ACTG, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundAntiretroviral regimens with simplified dosing and better safety are needed to maximize the efficiency of antiretroviral delivery in resource-limited settings. We investigated the efficacy and safety of antiretroviral regimens with once-daily compared to twice-daily dosing in diverse areas of the world.Methods and findings1,571 HIV-1-infected persons (47% women) from nine countries in four continents were assigned with equal probability to open-label antiretroviral therapy with efavirenz plus lamivudine-zidovudine (EFV+3TC-ZDV), atazanavir plus didanosine-EC plus emtricitabine (ATV+DDI+FTC), or efavirenz plus emtricitabine-tenofovir-disoproxil fumarate (DF) (EFV+FTC-TDF). ATV+DDI+FTC and EFV+FTC-TDF were hypothesized to be non-inferior to EFV+3TC-ZDV if the upper one-sided 95% confidence bound for the hazard ratio (HR) was ≤1.35 when 30% of participants had treatment failure. An independent monitoring board recommended stopping study follow-up prior to accumulation of 472 treatment failures. Comparing EFV+FTC-TDF to EFV+3TC-ZDV, during a median 184 wk of follow-up there were 95 treatment failures (18%) among 526 participants versus 98 failures among 519 participants (19%; HR 0.95, 95% CI 0.72-1.27; p = 0.74). Safety endpoints occurred in 243 (46%) participants assigned to EFV+FTC-TDF versus 313 (60%) assigned to EFV+3TC-ZDV (HR 0.64, CI 0.54-0.76; p

Published
2012

38. Prediction of serious complications in patients with pulmonary thromboembolism and solid cancer: Validation of the EPIPHANY Index in a prospective cohort of patients from the PERSEO study

Author

Sánchez-Cánovas, Manuel, primary, Jimenez-Fonseca, Paula, additional, Fernández Garay, David, additional, Cejuela Solís, Mónica, additional, Casado Elía, Diego, additional, Coma Salvans, Eva, additional, de la Haba Vacas, Irma, additional, Gómez Sánchez, David, additional, Fernández Montés, Ana, additional, Morales Giménez, Roberto, additional, Biosca Gómez de Tejada, Mercedes, additional, Arrazubi Arrula, Virginia, additional, Sequero López, Silvia, additional, Otero Candelera, Remedios, additional, Sánchez Cendra, Cristina, additional, Justo de la Peña, Marina, additional, Moreno Muñoz, Diana, additional, Orillo Sarmiento, Mayra, additional, Martínez de Castro, Eva, additional, García Escobar, Ignacio, additional, Bernal Vidal, Alejandro, additional, Ortega Moran, Laura, additional, Muñoz Martín, Andrés J., additional, Sánchez Bayona, Rodrigo, additional, Martínez Ortiz, María José, additional, Ayala de la Peña, Francisco, additional, Vicente, Vicente, additional, and Carmona-Bayonas, Alberto, additional

Published
2023
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42. Role of EpCAM+ CD133+ extracellular vesicles in steatosis to steatohepatitis transition in NAFLD

Author

Universidad de Sevilla. Departamento de Medicina, Consejeria de Economia, Conocimiento, Empresas y Universidad, Junta de Andalucia, Consejeria de salud y Familia, Instituto de Salud Carlos III, Junta de Andalucia, Sociedad Andaluza de patologia Digestiva, Muñoz Hernández, Rocío, Gato, Sheila, Gil-Gomez, Antonio, Aller, Rocio, Rojas, Angela, Moran, Laura, Ampuero Herrojo, Javier, Romero Gómez, Manuel, Universidad de Sevilla. Departamento de Medicina, Consejeria de Economia, Conocimiento, Empresas y Universidad, Junta de Andalucia, Consejeria de salud y Familia, Instituto de Salud Carlos III, Junta de Andalucia, Sociedad Andaluza de patologia Digestiva, Muñoz Hernández, Rocío, Gato, Sheila, Gil-Gomez, Antonio, Aller, Rocio, Rojas, Angela, Moran, Laura, Ampuero Herrojo, Javier, and Romero Gómez, Manuel

Abstract

Background and Aims Extracellular vesicles (EVs) have emerged as a potential source of circulating biomarkers in liver disease. We evaluated circulating AV+ EpCAM+ CD133+ EVs as a potential biomarker of the transition from simple steatosis to steatohepatitis. Methods EpCAM and CD133 liver proteins and EpCAM+ CD133+ EVs levels were analysed in 31 C57BL/6J mice fed with a chow or high fat, high cholesterol and carbohydrates diet (HFHCC) for 52 weeks. The hepatic origin of MVs was addressed using AlbCrexmT/mG mice fed a Western (WD) or Dual diet for 23 weeks. Besides, we assessed plasma MVs in 130 biopsy-proven NAFLD patients. Results Hepatic expression of EpCAM and CD133 and EpCAM+ CD133+ EVs increased during disease progression in HFHCC mice. GFP+ MVs were higher in AlbCrexmT/mG mice fed a WD (5.2% vs 12.1%) or a Dual diet (0.5% vs 7.3%). Most GFP+ MVs were also positive for EpCAM and CD133 (98.3% and 92.9% respectively), suggesting their hepatic origin. In 71 biopsy-proven NAFLD patients, EpCAM+ CD133+ EVs were significantly higher in those with steatohepatitis compare to those with simple steatosis (286.4 ± 61.9 vs 758.4 ± 82.3; p < 0.001). Patients with ballooning 367 ± 40.6 vs 532.0 ± 45.1; p = 0.01 and lobular inflammation (321.1 ± 74.1 vs 721.4 ± 80.1; p = 0.001), showed higher levels of these EVs. These findings were replicated in an independent cohort. Conclusions Circulating levels of EpCAM+ CD133+ MVs in clinical and experimental NAFLD were increased in the presence of steatohepatitis, showing high potential as a non-invasive biomarker for the evaluation and management of these patients.

Published
2023

43. ARCHER2 Net Zero Case Study

Author

Smith, Lorna, Simpson, Alan, Moran, Laura, and Turner, Andy

Subjects
Digital Research Infrastructure, ARCHER2, Net Zero, carbon cost, DRI, EPCC, HPC, High Performance Computing, UKRI
Abstract

ARCHER2 is the UK’s National HPC service, operated by EPCC, the University of Edinburgh, at theAdvanced Computing Facility. ARCHER2 provides an invaluable resource to UK academics to deliverworld-class research, including research into the impact of climate change. As part of the wider DRIscoping project, this case study has investigated the emissions associated with ARCHER2 and makes aseries of recommendations to move towards Net Zero for large-scale facilities of this type. A detailed analysis of ARCHER2 including its overall energy use, the type of electricity used and how this will impact on the carbon footprint of ARCHER2 over service lifetime, has been conducted. Also included areinvestigations into the embedded energy, (e.g. from PAIA or empirical analysis based on area of printed circuits).

Published
2023
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44. Emerging Technologies: Rust in HPC

Author

Moran, Laura and Bull, J. Mark

Abstract

This technical report is a short investigation into how Rust couldbe used for a scientific application in a HPC system. A computational fluid dynamics model of fluid flow into and out of a box was developed in Rust and compared to the same algorithm implementedin C and Fortran. These simulations were performed for both serial and parallelised versions over a variety of problem sizes. The report discusses the results of these simulations and the implications for using Rust as a tool for scientific programming in HPC.

Published
2023
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48. The Use of the LASSI (The Learning and Study Strategies Inventory) to Predict and Evaluate the Study Habits and Academic Performance of Students in a Learning Assistance Program

Author

Dill, Anna L., Justice, Cheryl A., Minchew, Sue S., Moran, Laura M., Wang, Chih-hsuan, and Weed, Candace B.

Abstract

The Learning Center (TLC) at Mississippi State University (MSU) is an academic support unit designed to help students improve their academic performance. One of the programs offered by TLC is the Learning Skills Support Program (LSSP), which is designed for academically suspended students. The Center has traditionally used the Learning and Study Strategies Inventory (LASSI) to determine the awareness and reported use of study skills of students enrolled in the LSSP. The purpose of this study was to determine whether the LSSP students improved in their awareness of study habits and academic mindsets by analyzing their LASSI scores. The researchers addressed the following questions: (a) whether there was or was not a significant difference between the pretest and the posttest LASSI scores of the LSSP students in the fall 2012 semester, and (b) whether there were or were not significant differences among the correlations between the posttest LASSI scale results and student success.

Published
2014
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50. Diet in a global cohort of adults with HIV at low-to-moderate traditional cardiovascular disease risk

Author

Fitch, Kathleen V., primary, McCallum, Sara A., additional, Erlandson, Kristine M., additional, Overton, Edgar Turner, additional, Zanni, Markella V., additional, Fichtenbaum, Carl, additional, Aberg, Judith A., additional, Fulda, Evelynne S., additional, Kileel, Emma M., additional, Moran, Laura E., additional, Bloomfield, Gerald S., additional, Novak, Richard M., additional, Pérez-Frontera, Sigrid, additional, Abrams-Downey, Alexandra, additional, Pierone, Gerald, additional, Kumarasamy, Nagalingeswaran, additional, Ruxrungtham, Kiat, additional, Mngqibisa, Rosie, additional, Douglas, Pamela S., additional, Ribaudo, Heather J., additional, and Grinspoon, Steven K., additional

Published
2022
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