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13 results on '"Moralez, Giulliana"'

1. Customization and external validation of the Simplified Mortality Score for the Intensive Care Unit (SMS-ICU) in Brazilian critically ill patients

Author

Zampieri, Fernando G., Granholm, Anders, Møller, Morten Hylander, Scotti, Alexandre Vaz, Alves, Alessandra, Cabral, Maurício Magalhães, Sousa, Marcelo Ferreira, Balieiro, Henrique Miller, Hortala, Carlos Cesar, Jr, Filho, Edison Moraes Rodrigues, Perecmanis, Eric, de Magalhães Menezes, Márcia Adélia, Moreira, Carlos Eduardo Nassif, Moralez, Giulliana Martines, Bafi, Antônio Tonete, de Carvalho, Clayton Barbieri, Salluh, Jorge Ibrain Figueira, Bozza, Fernando Augusto, Perner, Anders, and Soares, Marcio

Published
2020
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2. Association of frailty with short-term outcomes, organ support and resource use in critically ill patients

Author

Zampieri, Fernando G., Iwashyna, Theodore J., Viglianti, Elizabeth M., Taniguchi, Leandro U., Viana, William N., Costa, Roberto, Corrêa, Thiago D., Moreira, Carlos Eduardo N., Maia, Marcelo O., Moralez, Giulliana M., Lisboa, Thiago, Ferez, Marcus A., Freitas, Carlos Eduardo F., de Carvalho, Clayton B., Mazza, Bruno F., Lima, Mariza F. A., Ramos, Grazielle V., Silva, Aline R., Bozza, Fernando A., Salluh, Jorge. I. F., Soares, Marcio, and for the ORCHESTRA Study Investigators

Published
2018
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3. External validation of SAPS 3 and MPM0-III scores in 48,816 patients from 72 Brazilian ICUs

Author

Moralez, Giulliana Martines, Rabello, Ligia Sarmet Cunha Farah, Lisboa, Thiago Costa, Lima, Mariza da Fonte Andrade, Hatum, Rodrigo Marques, De Marco, Fernando Vinicius Cesar, Alves, Alessandra, Pinto, Jorge Eduardo da Silva Soares, de Araújo, Hélia Beatriz Nunes, Ramos, Grazielle Viana, Silva, Aline Reis, Fernandes, Guilherme Côrtes, Faria, Guilherme Brenande Alves, Mendes, Ciro Leite, Ramos Filho, Roberto Álvaro, de Souza, Valdênia Pereira, do Brasil, Pedro Emmanuel Alvarenga Americano, Bozza, Fernando Augusto, Salluh, Jorge Ibrain Figueira, Soares, Marcio, and On Behalf of the ORCHESTRA Study Investigators

Published
2017
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4. The effects of performance status one week before hospital admission on the outcomes of critically ill patients

Author

Zampieri, Fernando G., Bozza, Fernando A., Moralez, Giulliana M., Mazza, Débora D. S., Scotti, Alexandre V., Santino, Marcelo S., and Ribeiro, Rubens A. B.

Subjects
Medical research -- Analysis, Medicine, Experimental -- Analysis, Hospitals -- Admission and discharge, Mortality -- Brazil, Comorbidity -- Patient outcomes, Health care industry
Abstract

Purpose To assess the impact of performance status (PS) impairment 1 week before hospital admission on the outcomes in patients admitted to intensive care units (ICU). Methods Retrospective cohort study in 59,693 patients (medical admissions, 67 %) admitted to 78 ICUs during 2013. We classified PS impairment according to the Eastern Cooperative Oncology Group (ECOG) scale in absent/minor (PS = 0-1), moderate (PS = 2) or severe (PS = 3-4). We used univariate and multivariate logistic regression analyses to investigate the association between PS impairment and hospital mortality. Results PS impairment was moderate in 17.3 % and severe in 6.9 % of patients. The hospital mortality was 14.4 %. Overall, the worse the PS, the higher the ICU and hospital mortality and length of stay. In addition, patients with worse PS were less frequently discharged home. PS impairment was associated with worse outcomes in all SAPS 3, Charlson Comorbidity Index and age quartiles as well as according to the admission type. Adjusting for other relevant clinical characteristics, PS impairment was associated with higher hospital mortality (odds-ratio (OR) = 1.96 (95 % CI 1.63-2.35), for moderate and OR = 4.22 (3.32-5.35), for severe impairment). The effects of PS on the outcome were particularly relevant in the medium range of severity-of-illness. These results were consistent in the subgroup analyses. However, adding PS impairment to the SAPS 3 score improved only slightly its discriminative capability. Conclusion PS impairment was associated with worse outcomes independently of other markers of chronic health status, particularly for patients in the medium range of severity of illness., Author(s): Fernando G. Zampieri [sup.1] [sup.2], Fernando A. Bozza [sup.3] [sup.4], Giulliana M. Moralez [sup.3] [sup.5], Débora D. S. Mazza [sup.6], Alexandre V. Scotti [sup.7], Marcelo S. Santino [sup.8], Rubens [...]

Published
2017
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5. A phase I study of mTOR inhibitor everolimus in association with cisplatin and radiotherapy for the treatment of locally advanced cervix cancer: PHOENIX I

Author

de Melo, Andréia Cristina, Grazziotin-Reisner, Rachele, Erlich, Felipe, Fontes Dias, Mariane S., Moralez, Giulliana, Carneiro, Michel, Ingles Garces, Álvaro Henrique, Guerra Alves, Flávia Vieira, Novaes Neto, Bruna, Fuchshuber-Moraes, Mateus, Morando, Juliane, Suarez-Kurtz, Guilherme, and Ferreira, Carlos Gil

Published
2016
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6. Clinical Characteristics and In-Hospital Mortality of Cardiac Arrest Survivors in Brazil: A Large Retrospective Multicenter Cohort Study

Author

Kurtz, Pedro, primary, Storm, Christian, additional, Soares, Marcio, additional, Bozza, Fernando, additional, Maciel, Carolina B., additional, Greer, David M., additional, Bastos, Leonardo S. L., additional, Melo, Ulisses, additional, Mazza, Bruno, additional, Santino, Marcelo S., additional, Seabra Lannes, Roberto, additional, de Moraes, Ana Paula Pierre, additional, Passos, Joel Tavares, additional, Moralez, Giulliana Martines, additional, Santos, Robson Correa, additional, Machado, Maristela Medeiros, additional, Saturnino, Saulo Fernandes, additional, Mendes, Ciro Leite, additional, Oswaldo Vianna, Arthur, additional, and Salluh, Jorge, additional

Published
2021
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8. Resuscitation fluid practices in Brazilian intensive care units: a secondary analysis of Fluid-TRIPS

Author

Freitas, Flavio Geraldo Rezende de, primary, Hammond, Naomi, additional, Li, Yang, additional, Azevedo, Luciano Cesar Pontes de, additional, Cavalcanti, Alexandre Biasi, additional, Taniguchi, Leandro, additional, Gobatto, André, additional, Japiassú, André Miguel, additional, Bafi, Antonio Tonete, additional, Mazza, Bruno Franco, additional, Noritomi, Danilo Teixeira, additional, Dal-Pizzol, Felipe, additional, Bozza, Fernando, additional, Salluh, Jorge Ibrahin Figueira, additional, Westphal, Glauco Adrieno, additional, Soares, Márcio, additional, Assunção, Murillo Santucci César de, additional, Lisboa, Thiago, additional, Lobo, Suzana Margarete Ajeje, additional, Barbosa, Achilles Rohlfs, additional, Ventura, Adriana Fonseca, additional, Souza, Ailson Faria de, additional, Silva, Alexandre Francisco, additional, Toledo, Alexandre, additional, Reis, Aline, additional, Cembrane, Allan, additional, Rea Neto, Alvaro, additional, Gut, Ana Lúcia, additional, Justo, Ana Patricia Pierre, additional, Santos, Ana Paula, additional, Albuquerque, André Campos D. de, additional, Scazufka, André, additional, Rodrigues, Antonio Babo, additional, Fernandino, Bruno Bonaccorsi, additional, Silva, Bruno Goncalves, additional, Vida, Bruno Sarno, additional, Pinheiro, Bruno Valle, additional, Pinto, Bruno Vilela Costa, additional, Feijo, Carlos Augusto Ramos, additional, Abreu Filho, Carlos de, additional, Bosso, Carlos Eduardo da Costa Nunes, additional, Moreira, Carlos Eduardo Nassif, additional, Ramos, Carlos Henrique Ferreira, additional, Tavares, Carmen, additional, Arantes, Cidamaiá, additional, Grion, Cintia, additional, Mendes, Ciro Leite, additional, Kmohan, Claudio, additional, Piras, Claudio, additional, Castro, Cristine Pilati Pileggi, additional, Lins, Cyntia, additional, Beraldo, Daniel, additional, Fontes, Daniel, additional, Boni, Daniela, additional, Castiglioni, Débora, additional, Paisani, Denise de Moraes, additional, Pedroso, Durval Ferreira Fonseca, additional, Mattos, Ederson Roberto, additional, Brito Sobrinho, Edgar de, additional, Troncoso, Edgar M. V., additional, Rodrigues Filho, Edison Moraes, additional, Nogueira, Eduardo Enrico Ferrari, additional, Ferreira, Eduardo Leme, additional, Pacheco, Eduardo Souza, additional, Jodar, Euzebio, additional, Ferreira, Evandro L. A., additional, Araujo, Fabiana Fernandes de, additional, Treviso, Fabiana Schuelter, additional, Amorim, Fábio Ferreira, additional, Giannini, Fabio Poianas, additional, Santos, Fabrício Primitivo Matos, additional, Buarque, Fátima, additional, Lima, Felipe Gallego, additional, Costa, Fernando Antonio Alvares da, additional, Sad, Fernando Cesar dos Anjos, additional, Aranha, Fernando G., additional, Ganem, Fernando, additional, Callil, Flavio, additional, Costa Filho, Francisco Flávio, additional, Dall´Arto, Frederico Toledo Campo, additional, Moreno, Geovani, additional, Friedman, Gilberto, additional, Moralez, Giulliana Martines, additional, Silva, Guilherme Abdalla da, additional, Costa, Guilherme, additional, Cavalcanti, Guilherme Silva, additional, Betônico, Gustavo Navarro, additional, Reis, Hélder, additional, Araujo, Helia Beatriz N., additional, Hortiz Júnior, Helio Anjos, additional, Guimaraes, Helio Penna, additional, Urbano, Hugo, additional, Maia, Israel, additional, Santiago Filho, Ivan Lopes, additional, Farhat Júnior, Jamil, additional, Alvarez, Janu Rangel, additional, Passos, Joel Tavares, additional, Paranhos, Jorge Eduardo da Rocha, additional, Marques, José Aurelio, additional, Moreira Filho, José Gonçalves, additional, Andrade, Jose Neto, additional, C Sobrinho, José Onofre de, additional, Bezerra, Jose Terceiro de Paiva, additional, Alves, Juliana Apolônio, additional, Ferreira, Juliana, additional, Gomes, Jussara, additional, Sato, Karina Midori, additional, Gerent, Karine, additional, Teixeira, Kathia Margarida Costa, additional, Conde, Katia Aparecida Pessoa, additional, Martins, Laércia Ferreira, additional, Figueirêdo, Lanese, additional, Rezegue, Leila, additional, Tcherniacovsk, Leonardo, additional, Ferraz, Leone Oliveira, additional, Cavalcante, Liane, additional, Rabelo, Ligia, additional, Miilher, Lilian, additional, Garcia, Lisiane, additional, Tannous, Luana, additional, Hajjar, Ludhmila Abrahão, additional, Paciência, Luís Eduardo Miranda, additional, Cruz Neto, Luiz Monteiro da, additional, Bley, Macia Valeria, additional, Sousa, Marcelo Ferreira, additional, Puga, Marcelo Lourencini, additional, Romano, Marcelo Luz Pereira, additional, Nobrega, Marciano, additional, Arbex, Marcio, additional, Rodrigues, Márcio Leite, additional, Guerreiro, Márcio Osório, additional, Rocha, Marcone, additional, Alves, Maria Angela Pangoni, additional, Rosa, Maria Doroti, additional, Dias, Mariza D’Agostino, additional, Martins, Miquéias, additional, Oliveira, Mirella de, additional, Moretti, Miriane Melo Silveira, additional, Matsui, Mirna, additional, Messender, Octavio, additional, Santarém, Orlando Luís de Andrade, additional, Silveira, Patricio Júnior Henrique da, additional, Vassallo, Paula Frizera, additional, Antoniazzi, Paulo, additional, Gottardo, Paulo César, additional, Correia, Paulo, additional, Ferreira, Paulo, additional, Torres, Paulo, additional, Silva, Pedro Gabrile M. de Barros e, additional, Foernges, Rafael, additional, Gomes, Rafael, additional, Moraes, Rafael, additional, Nonato filho, Raimundo, additional, Borba, Renato Luis, additional, Gomes, Renato V, additional, Cordioli, Ricardo, additional, Lima, Ricardo, additional, López, Ricardo Pérez, additional, Gargioni, Ricardo Rath de Oliveira, additional, Rosenblat, Richard, additional, Souza, Roberta Machado de, additional, Almeida, Roberto, additional, Narciso, Roberto Camargo, additional, Marco, Roberto, additional, waltrick, Roberto, additional, Biondi, Rodrigo, additional, Figueiredo, Rodrigo, additional, Dutra, Rodrigo Santana, additional, Batista, Roseane, additional, Felipe, Rouge, additional, Franco, Rubens Sergio da Silva, additional, Houly, Sandra, additional, Faria, Sara Socorro, additional, Pinto, Sergio Felix, additional, Luzzi, Sergio, additional, Sant’ana, Sergio, additional, Fernandes, Sergio Sonego, additional, Yamada, Sérgio, additional, Zajac, Sérgio, additional, Vaz, Sidiner Mesquita, additional, Bezerra Bezerra, Silvia Aparecida, additional, Farhat, Tatiana Bueno Tardivo, additional, Santos, Thiago Martins, additional, Smith, Tiago, additional, Silva, Ulysses V. A., additional, Damasceno, Valnei Bento, additional, Nobre, Vandack, additional, Dantas, Vicente Cés de Souza, additional, Irineu, Vivian Menezes, additional, Bogado, Viviane, additional, Nedel, Wagner, additional, Campos Filho, Walther, additional, Dantas, Weidson, additional, Viana, William, additional, Oliveira Filho, Wilson de, additional, Delgadinho, Wilson Martins, additional, Finfer, Simon, additional, and Machado, Flavia Ribeiro, additional

Published
2021
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10. The effects of performance status one week before hospital admission on the outcomes of critically ill patients

Author

Zampieri, Fernando G., primary, Bozza, Fernando A., additional, Moralez, Giulliana M., additional, Mazza, Débora D. S., additional, Scotti, Alexandre V., additional, Santino, Marcelo S., additional, Ribeiro, Rubens A. B., additional, Rodrigues Filho, Edison M., additional, Cabral, Maurício M., additional, Maia, Marcelo O., additional, D’Alessandro, Patrícia S., additional, Oliveira, Sandro V., additional, Menezes, Márcia A. M., additional, Caser, Eliana B., additional, Lannes, Roberto S., additional, Alencar Neto, Meton S., additional, Machado, Maristela M., additional, Sousa, Marcelo F., additional, Salluh, Jorge I. F., additional, and Soares, Marcio, additional

Published
2016
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11. Abstract CT403: A Phase I study of oral administration of mTOR inhibitor everolimus (E) in association with cisplatin (C) and radiotherapy (R) for the treatment of locally advanced cervix cancer (LACC) - PHOENIX I

Author

Ferreira, Carlos Gil, primary, Alves, Flávia V. Guerra, additional, Grazziotin, Rachele, additional, Erlich, Felipe, additional, Moralez, Giulliana, additional, Carneiro, Michel P., additional, Dias, Mariane Fontes, additional, and Melo, Andréia C. de, additional

Published
2014
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12. A phase I study of mTOR inhibitor everolimus in association with cisplatin and radiotherapy for the treatment of locally advanced cervix cancer: PHOENIX I.

Author

Melo, Andréia, Grazziotin-Reisner, Rachele, Erlich, Felipe, Fontes Dias, Mariane, Moralez, Giulliana, Carneiro, Michel, Ingles Garces, Álvaro, Guerra Alves, Flávia, Novaes Neto, Bruna, Fuchshuber-Moraes, Mateus, Morando, Juliane, Suarez-Kurtz, Guilherme, Ferreira, Carlos, de Melo, Andréia Cristina, Fontes Dias, Mariane S, Ingles Garces, Álvaro Henrique, Guerra Alves, Flávia Vieira, and Ferreira, Carlos Gil

Subjects
CERVICAL cancer treatment, CANCER in women, EVEROLIMUS, CISPLATIN, CANCER radiotherapy, MTOR protein, CLINICAL trials, THERAPEUTICS
Abstract

Background: Cervix cancer (CC) represents the fourth most common cancer in women. Treatment involving cisplatin and radiotherapy has been the standard for locally advanced disease. Everolimus inhibits the aberrant activity of mTOR that is part of carcinogenesis in CC. Further everolimus inactivates the HPV E7 oncoprotein and inhibits its proliferation. Preclinical models have suggested that everolimus sensitizes tumoral cells and vasculature to cisplatin and radiotherapy.Methods: In a 3 + 3 design, the trial aimed to treat three dose levels of at least three patients with daily doses of everolimus (2.5, 5 and 10 mg/day), cisplatin and radiotherapy delivered in a 9-week interval in CC patients, stage IIB, IIIA or IIIB. Patients received everolimus from day -7 up to the last day of brachytherapy. Primary objective was to evaluate safety, toxicity and the maximum-tolerated dose (MTD) of everolimus in association with cisplatin and radiotherapy. Pharmacokinetic (PK) parameters and response rates were analyzed as secondary objectives.Results: Thirteen patients were enrolled, 6 at 2.5 mg, 3 at 5 mg and 4 at 10 mg. Four patients did not complete the planned schedule, 1 at 2.5 mg presented grade 4 acute renal failure interpreted as dose-limiting toxicity (DLT) and 3 at 10 mg: 1 with disease progression, and 2 with DLTs-1 grade 3 rash and 1 grade 4 neutropenia. PK results were characterized by dose-dependent increases in AUC and C max.Conclusions: The MTD of everolimus in combination with cisplatin and radiotherapy has been defined as 5 mg/day. The data regarding safety and response rates support further studies. [ABSTRACT FROM AUTHOR]

Published
2016
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13. Phase I Trial of Erlotinib Combined with Cisplatin and Radiotherapy for Patients with Locally Advanced Cervical Squamous Cell Cancer

Author

Nogueira-Rodrigues, Angélica, primary, do Carmo, Cláudio C., additional, Viegas, Célia, additional, Erlich, Felipe, additional, Camisão, Cláudia, additional, Fontão, Karina, additional, Lima, Roberta, additional, Herchenhorn, Daniel, additional, Martins, Renato G., additional, Moralez, Giulliana M., additional, Small, Isabele A., additional, and Ferreira, Carlos G., additional

Published
2008
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