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153 results on '"Morales-Gomez, A."'

1. Vision Algorithm to Compute Pupil Parameters: Towards Non-invasive Estimation of Intracranial Pressure

Author

De La Rosa Hernández, Gerardo Adrián, Morales Gómez, Jesús Alberto, Quiroz Compean, Griselda, Torres Treviño, Luis Martín, Magjarević, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Flores Cuautle, José de Jesús Agustín, editor, Benítez-Mata, Balam, editor, Salido-Ruiz, Ricardo Antonio, editor, Alonso-Silverio, Gustavo Adolfo, editor, Dorantes-Méndez, Guadalupe, editor, Zúñiga-Aguilar, Esmeralda, editor, Vélez-Pérez, Hugo A., editor, Hierro-Gutiérrez, Edgar Del, editor, and Mejía-Rodríguez, Aldo Rodrigo, editor

Published
2024
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3. Mapping the dynamics between violence and alcohol outlets in Scotland using data from ambulance services.

Author

Susan McVie and Ana Morales-Gomez

Subjects
Demography. Population. Vital events, HB848-3697
Abstract

Objective In Scotland, the link between alcohol consumption and violent crime remains a significant concern. This study aims to explore the association between assault-related incidents captured by health services in Scotland and the availability and density of alcohol premises in Scotland. Approach Scotland has experienced an overall decline in violence in the last years; however, this trend varies significantly across different regions. Research has shown the importance of analysing the spatial and social contexts in which violence occurs. Using linked administrative data from ambulance services and a geographically aggregated dataset of the location of licensed outlets selling alcohol, we explore the link between place, alcohol premises densities and violence using regression models. Results Our findings show that violent incidents are concentrated in the most deprived areas and places with higher availability of alcohol premises. However, areas with a higher number of off-sales premises showed a higher prevalence of violent incidents than those with a higher number of on-sales premises. In addition, violent incidents exhibit an uptick during weekends, evenings, and early mornings, suggesting a link to the night-time economy. Conclusions and Implications The persistence of violence in Scotland, particularly in deprived areas with high concentrations of alcohol outlets, emphasise the need for public policies and interventions aimed at mitigating the adverse effects of alcohol-related violence. Data linkage between health services and police can contribute to understanding the spatial and social contexts in which violence occurs and could inform the design of focused crime prevention and public health approaches.

Published
2024
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4. Colombian surgical outcomes study insights on perioperative mortality rate, a main indicator of the lancet commission on global surgery – a prospective cohort study

Author

Pérez Rivera, Carlos J., Lozano-Suárez, Nicolás, Agudelo-Mendoza, Silvia Valentina, Bohórquez-Tarazona, Maria Paz, García-Zambrano, Laura, Lara-Espinosa, Daniela, Polania-Sandoval, Camilo Andres, Rojas-Serrano, Luisa Fernanda, Vargas-Cuéllar, María Paula, Velandia-Sánchez, Alejandro, Cabrera-Rivera, Paulo Andrés, Briceno-Ayala, Leonardo, Cruz-Reyes, Danna, Barrera Carvajal, Juan Guillermo, Cabrera-Vargas, Luis Felipe, Guevara, Oscar, Arce Polania, Laura Cristina, Buendía Barrios, Laura Natalia, Cristina Camargo Areyanes, María Isabel, Casas, Felipe, Alfaro, Valeria Cormane, García-Méndez, Juan P., Guerra, Bayron, Idarraga-Ayala, Sharon V., Abiyomaa, Akram Kadamani, Montoya, Christopher, Mosquera Paz, Manuel Santiago, Pineda, María Alejandra, Pinzón-Luna, Juliana, Bastidas, Isabella Roa, Roman Ortega, Carlos Fernando, Saavedra Henao, Juan D., SanJuan-Arias, Laura Carolina, Barreto, Vanessa, Corso, Julian, Maksoud-Garcia, Mariana, Mateus, Eliana Pineda, Zabaraín, Alejandra Vega, Mantilla-Sylvain, Fabien, Perez, Nicolas, Alzate-Ricaurte, Sergio, Bejarano, Monica, Caicedo Holguin, Isabella, García, Alberto Federico, Sanchez, Stefania Rodriguez, Santos, Felipe Bernal, Jaspe, Carlos Luna, Maria Camila Luna-Jaspe Roa, OLIVERA Bolívar, Maria Paula, Diaz, MariaFernanda Valdivieso, Agudelo, Yuli, Castillo-Aristizábal, Maria Paula, Hoyos Burgos, Juan Pablo, Maria Clara Mendoza Arango, Maria Clara, Gabriel Arroyave, Preciado, Felipe Buitrago, Cardona González, Lina María, Correa-Cote, Juan Camilo, Franco Arias, Karen Lorena, Llano Sierra, Juan Felipe, López, Gustavo, Mancero, Cesar, Parra, Sebastian, Gonzalez, Beatriz Ramirez, Daniela Sierra, Amaya Muñoz, Maria Camila, Blanco-Ramírez, Ashley, Camacho, Paul Anthony, Campillo, Jorge, Carvajal Mejia, Andrea Ximena, María Alejandra González Yamil, Osorno Villegas, Juan Carlos, Eduardo Rubio, Herrera, Santiago Sánchez, Herrera, Sebastian Sanchez, Agudelo, Tatiana, Andrade, Valentina, Pérez, Laura Arango, Ariza-Gutiérrez, Anibal, Jacobo Berrio, Torres, Natalia Cantillo, Chamorro-Rodríguez, Maria Valeria, Conde, Lucia, Feo Lee, Oscar Hernando, González Nieto, María Camila, Ibañez-Pintor, Laura Cecilia, Ochoa, Catalina, Ospina, Juan, Pérez-Ocampo, Juan José, Rojas, Esteban Portilla, Rey, Daniela Saaibi, Serrano, Eduardo, Solorza Velásquez, Sharon Michelle, Toro Cubides, Angélica María, Aguiar, Raúl, Beltrán Rincón, Diego Armando, Figueroa, Juan Sebastian, Figueroa-Casanova, Rafael, Gonzalez Mosos, Maria Fernanda, Marcia Gabriela Gómez, Osorno, Susana, Laura Palacio, Laura, Venegas, Jose, Caicedo Ramírez, Liliana Marcela, Cardona Gomez, Diana Catalina, Alejandro Fernandez Bolaños, Daniel, Fernández-Diago, Adriana, Olave Montaño, Victor David, Pastás, César, Amorocho, Silvia Marcela, Barbosa-Santibañez, Jorge, Baron, Vladimir, Cartagena-Alvarado, Alejandra, Castillo, Maria, Castillo-Florez, Maria Carolina, Dimian Mayorga, Omar David, Delgado-Nieto, Elena Leonor, Fajardo, Ernesto, Gomez Polania, Omar Leonardo, Gonzalez, Tania, Guzman Mesa, Daniel Felipe, Isaza-Restrepo, Andres, Leal, Jaime A., Medina, Camilo, Navarro-Alean, Jorge, Ocampo, Maria Antonia, Oliveros, Guillermo, Ortiz, Maria, Ortiz-Mahecha, Jorge I., Abaunza, Katherine Parra, Pulido Reyes, Felipe Antonio, Rivera-Rincón, Natalia, Carlos Alfonso Rodriguez Pinedo, Sanchez, Lizeth Rodriguez, Romero, Juan Javier, Sabogal Olarte, Juan Carlos, Salgado Tovar, Javier Mauricio, Torres, Guillermo Andrés, Vallejo, Linda, Vargas-Barato, Felipe, Vargas Patiño, Ana María, Villate León, Juan Pablo, Montañez Aldana, Miguel Angel, Norato, Chiara, Borda, Hugo Rojas, Núñez, Miguel Á Romero, Sánchez, Alejandro, López, Jose Támara, Támara P, Jose, Wilmer Fernando Botache Capera, Rojas, Rolando Medina, Juan Torres, Trujillo, Gina Catalina, Cubillos Saavedra, Gabriela Estefanía, Francisco García-Laverde, Naffah Enciso, Jussef Camilo, Betancur, Julian Arango, Cortés-Coronado, Adriana, Susana Sepúlveda Tamayo, Cardenas, Valentina Arboleda, García-Barrero, Luis Guillermo, Jhonatan Enrique Garzón-Galindo, Torres Parada, Lina Fernanda, Quintero, Alejandro Arias, Cano, David, Montoya Quintero, Kevin Fernando, Santiago Nieto Muñoz, Mejía, Paula Saza, Gomez Barrios, Jesus David, Jimeno, María Angélica, Restrepo Hernandez, Ghandi Ignacio, Rodríguez-Sequea, Adrian, Varón Cotes, Juan Carlos, Hanner Enrique Acevedo Reyes, Barandica Bolaño, Claudia Marcela, Sierra-Cote, Maria Camila, Angarita Vargas, Laura Daniela, Báez Ramírez, Alix Yurany, Rodriguez Suarez, Jose Armando, Sánchez, David Leonardo, Sandoval Rangel, Silvia Natalia, Hurtado, Edwin Ulloa, Hernández Almanza, Olga Esther, Martínez Zubiria, Rosalba Inmaculada, Muegues Salas, Angel Alexis, Becerra Cardona, Diego Alexander, Cárdenas Santamaría, Fabio Hernán, Echeverri Castaño, Juan Daniel, Echeverri Uribe, Juan Sebastián, Gaitán Buitrago, María Helena, Galvis Valencia, Luis Felipe, Sabogal, Andrea Henao, López Atehortúa, David Felipe, Molina Uribe, Juan Manuel, Peñate Suárez, Edwin Enrique, Valencia, Heiller Torres, Salazar, Marcela Velásquez, Correa, Catalina, García, Hans, Leal, Juan Hernández, Muñoz Vargas, Paula Tatiana, Bolívar Sáenz, Dínimo José, Caicedo Medina, Camilo Andrés, Garcia Riaño, Camilo Andres, Gonzalez, Stephanye Carrillo, Gómez, Jaime Lorduy, Madrid, Carlos Torres, Villa, Walter Torres, Luengas Orozco, Juan Sebastian, Capriles, Camilo Avendaño, Blanco, Carolina Diaz, Brieva Hoyos, Maria Lucía, Cantillo Moreno, Paola Andrea, Granados Mendoza, Sofía Carolina, Vizcaino Lara, José Dario, Babativa Peñuela, Karla Lizeth, Jiménez Bahamón, Paula Andrea, Maldonado Rico, Jhonier Estiven, Martínez Cortes, Duvan Ernesto, Orjuela Aragón, José Alfredo, Castro Roa, Lizeth Daniela, Gallego, Julieth Sarmiento, Herazo Meza, Marta Maria, Hernández Castillo, Anlly Caterin, Rojas Moncada, Rosa Gabriela, Casanova Bermeo, Lucia Fernanda, Cortés Otero, Oscar Fernando, Pinilla, Nicolás Diaz, Herrera Delgado, Harrison Rene, Macías Segura, Simon Alberto, Muñoz Castrillón, David Ramiro, Nuñez Romero, Luis Ramiro, Polania Andrade, Cesar Andrés, Valdez Toro, Hector Alejandro, Cardozo Parrado, Ana María, Moros, Jose Gonzalo, Nieto, Paula Andrea, Patarroyo, Jorge Mario, Perilla Martínez, Jose Luis, Gutierrez, María del Pilar Torres, Benito Flórez, Erika Johana, Gómez, Mariana Vergel, Robayo Rodriguez, Diana Ximena, Salcedo Miranda, Diego Fernando, Triviño Cortés, Maria Alejandra, Sastre, William Baquero, Bonett, Juan Sebastian, Cortes, Eliana, Duque, Pedro Fernando, Gutierrez, Carlos Enrique, Echeverry, Piedad, Motta Amar, Andrés Felipe, Torres, Lorena, Bautista, Jeremias Carvajal, Figueroa Bohórquez, David Mauricio, Quintana, Manuel Latorre, Olivera Briñez, Diego Fernando, Quintero Contreras, Marcel Leonardo, Gamboa, Raúl Vera, Zapata, Mariana Arias, Benavides Caipe, Cristhian Daniel, Betancur Acevedo, Luisa Fernanda, Zuluaga, Valentina Botero, Figueroa-Espinoza, Vanessa, Londoño-Patiño, Arbey Leandro, Moncayo-Gonzalez, Santiago, Puerta Suárez, Laura Sofia, Vargas-Arboleda, Paula Camila, Gonzalez Cera, Lisbet Sofia, Toro, Katerine Henao, de Jesus Ortiz Pino, Leobardo, Vasquez Vargas, Sergio Andrés, Zuluaga, Lency Naranjo, Garzón, Jaime Chamorro, Franco Rodriguez, Adriana Paola, Acosta Alape, Nataly Johana, Arbelaez Mariño, Andrés Felipe, Mora Herrera, Juan José, Ayala Muñoz, Javier Felipe, Camacho Pinzon, Yeiny Carina, Cárdenas Chacón, José Francisco, Peña Arenas, Liliana Andrea, Rodriguez Camargo, Gustavo Adolfo, Sánchez Arango, Carlos Alberto, Bolaños Ñañez, Daniel Mauricio, Garcés-Palacios, Diana Sofía, Ñañez Pantoja, María Alejandra, Ortega-Valencia, Omar Alejandro, Gamboa Bernal, María Paula, Lotero Gómez, Juan David, Martínez-Gutiérrez, Juan Sebastián, Morales-Gómez, Daniel, Pardo-Jiménez, Lina, Fonseca Galindo, Leon Miguel, Garcia Ramirez, Angélica Maria, Saurith Ramirez, Juan David, Barrero Montoya, Ivan Ricardo, Espitia, Santiago Cadena, Rojas, Salomé Pallares, Zapata Berrio, Laura Camila, Benavides Rodríguez, Diana Andrea, Gonzalez, Juan Carlos, Idarraga, Sharon Valentina, Márquez Rodríguez, Óscar Eduardo, Marrugo Prieto, Ivi Yohana, Soledad Machado, Laura Vanessa, Luna, Rubén, Pulido, Nicolás Navarro, Nuñez Ricardo, Federico Javier, García López, Andrea Elena, Luque, Fernando Girón, Jaramillo, Nasly Patiño, Pedraza Alonso, Néstor Fabian, Acuña Acuña Rivera JY, Javier Yecid, Guevara Cruz, Oscar Alexander, Martínez Buitrago, Juan Sebastián, Oviedo, Nathalia Montoya, Santafe Guerrero, Marcia Roxana, Chaves Cortés, Juanita Carolina, Rincón Tello, Francisco Mauricio, Bejarano Ramirez, Diana Fernanda, Cortes Mejia, Nicolas Andres, Garzon Mesa, Camilo Ernesto, Pabon, Alejandra Moncada, Triviño Alvarez, Diego Rymel, Torres, Alonso Vera, Cote Martinez, Maria Alejandra, Machado Rodriguez, Juan Manuel, Martinez, Gonzalo Nuñez, Osuna, Laura Naranjo, Roldan Garay, Andres Felipe, Amado, Daniel, Camacho-Mackenzie, Jaime, Maria Ceballos Mora, Cifuentes-Navarrete, Sara, Donoso-Samper, Andrea, Ferro, Manuel A., Gómez-Cáceres, Juan C., Gómez-Galán, Sebastián, Leiva, Ana G., Lisarazo, Juan, López-Castaño, Maria G., Martínez-Gil, Sofía, Montoya, M.J., Niño-Basto, Santiago, Ortigoza-Espitia, Sergio Andrés, Páez, Gustavo, Ramos-Anaya, Jesús William, Rozo, María J., Umana, Juan P., Amar, Andres Motta, Barrera Vargas, Andrés Felipe, Maldonado Escalante, Javier Dario, Molina Marroquin, German Ricardo, Prada Lievano, Silvia Alejandra, Vargas-Cuellar, Maria Paula, Polanía-Sandoval, Camilo A., and Cabrera-Rivera, Paulo A.

Published
2024
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7. Minimal impacts of invasive Scaevola taccada on Scaevola plumieri via pollinator competition in Puerto Rico

Author

Susan M. Swensen, Adriana Morales Gomez, Colette Piasecki-Masters, Ngawang Chime, Abigail R. Wine, Nandadevi Cortes Rodriguez, James Conklin, and Peter J. Melcher

Subjects
Scaevola plumieri, Scaevola taccada, Goodeniaceae, pollination, invasive, Plant culture, SB1-1110
Abstract

IntroductionScaevola taccada and Scaevola plumieri co-occur on shorelines of the Caribbean. Scaevola taccada is introduced in this habitat and directly competes with native dune vegetation, including S. plumieri, a species listed as locally endangered and threatened in Caribbean locations. This study addresses whether the invasive S. taccada also impacts the native S. plumieri indirectly by competing for pollinators and represents the first comparative study of insect visitation between these species.MethodsInsect visitation rates were measured at sites where species co-occur and where only the native occurs. Where species cooccur, insect visitors were captured, identified and analyzed for the pollen they carry. Pollen found on open-pollinated flowers was analyzed to assess pollen movement between the two species. We also compared floral nectar from each species by measuring volume, sugar content, and presence and proportions of amine group containing constituents (AGCCs).ResultsOur results demonstrate that both species share insect visitors providing the context for possible pollinator competition, yet significant differences in visitation frequency were not found. We found evidence of asymmetrical heterospecific pollen deposition in the native species, suggesting a possible reproductive impact. Insect visitation rates for the native were not significantly different between invaded and uninvaded sites, suggesting that the invasive S. taccada does not limit pollinator visits to S. plumieri. Comparisons of nectar rewards from the invasive and the native reveal similar volumes and sugar concentrations, but significant differences in some amine group containing constituents that may enhance pollinator attraction.ConclusionOur analysis finds no evidence for pollination competition and therefore S. taccada’s main impacts on S. plumieri are through competitive displacement and possibly through reproductive impacts as a consequence of heterospecific pollen deposition.

Published
2024
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8. Cardiovascular Outcomes in GRADE (Glycemia Reduction Approaches in Type 2 Diabetes: A Comparative Effectiveness Study)

Author

Green, Jennifer B., Everett, Brendan M., Ghosh, Alokananda, Younes, Naji, Krause-Steinrauf, Heidi, Barzilay, Joshua, Desouza, Cyrus, Inzucchi, Silvio E., Pokharel, Yashashwi, Schade, David, Scrymgeour, Alexandra, Tan, Meng H., Utzschneider, Kristina M., Mudaliar, Sunder, Crandall, J.P., McKee, M.D., Behringer-Massera, S., Brown-Friday, J., Xhori, E., Ballentine-Cargill, K., Duran, S., Estrella, H., Gonzalez de la Torre, S., Lukin, J., Phillips, L.S., Burgess, E., Olson, D., Rhee, M., Wilson, P., Raines, T.S., Boers, J., Costello, J., Maher-Albertelli, M., Mungara, R., Savoye, L., White, C.A., Gullett, C., Holloway, L., Morehead, F., Person, S., Sibymon, M., Tanukonda, S., Adams, C., Ross, A., Balasubramanyam, A., Gaba, R., Gonzalez Hattery, E., Ideozu, A., Jimenez, J., Montes, G., Wright, C., Hollander, P., Roe, E., Jackson, A., Smiley, A., Burt, P., Estrada, L., Chionh, K., Ismail-Beigi, F., Falck-Ytter, C., Sayyed Kassem, L., Sood, A., Tiktin, M., Kulow, T., Newman, C., Stancil, K.A., Cramer, B., Iacoboni, J., Kononets, M.V., Sanders, C., Tucker, L., Werner, A., Maxwell, A., McPhee, G., Patel, C., Colosimo, L., Krol, A., Goland, R., Pring, J., Alfano, L., Kringas, P., Hausheer, C., Tejada, J., Gumpel, K., Kirpitch, A., Schneier, H., AbouAssi, H., Chatterjee, R., Feinglos, M.N., English Jones, J., Khan, S.A., Kimpel, J.B., Zimmer, R.P., Furst, M., Satterwhite, B.M., Thacker, C.R., Evans Kreider, K., Mariash, C.N., Mather, K.J., Ismail, H.M., Lteif, A., Mullen, M., Hamilton, T., Patel, N., Riera, G., Jackson, M., Pirics, V., Aguillar, D., Howard, D., Hurt, S., Bergenstal, R., Carlson, A., Martens, T., Johnson, M., Hill, R., Hyatt, J., Jensen, C., Madden, M., Martin, D., Willis, H., Konerza, W., Yang, S., Kleeberger, K., Passi, R., Fortmann, S., Herson, M., Mularski, K., Glauber, H., Prihoda, J., Ash, B., Carlson, C., Ramey, P.A., Schield, E., Torgrimson-Ojerio, B., Arnold, K., Kauffman, B., Panos, E., Sahnow, S., Bays, K., Berame, K., Cook, J., Ghioni, D., Gluth, J., Schell, K., Criscola, J., Friason, C., Jones, S., Nazarov, S., Rassouli, N., Puttnam, R., Ojoawo, B., Nelson, R., Curtis, M., Hollis, B., Sanders-Jones, C., Stokes, K., El-Haqq, Z., Kolli, A., Tran, T., Wexler, D., Larkin, M.E., Meigs, J., Chambers, B., Dushkin, A., Rocchio, G., Yepes, M., Steiner, B., Dulin, H., Cayford, M., Chu, K., DeManbey, A., Hillard, M., Martin, K., Thangthaeng, N., Gurry, L., Kochis, R., Raymond, E., Ripley, V., Stevens, C., Park, J., Aroda, V., Ghazi, A., Magee, M., Ressing, A., Loveland, A., Hamm, M., Hurtado, M., Kuhn, A., Leger, J., Manandhar, L., Mwicigi, F., Sanchez, O., Young, T., Garg, R., Lagari-Libhaber, V., Florez, H.J., Valencia, W.M., Marks, J., Casula, S., Oropesa-Gonzalez, L., Hue, L., Cuadot, A., Nieto-Martinez, R., Riccio Veliz, A.K., Gutt, M., Kendal, Y.J., Veciana, B., Ahmann, A., Aby-Daniel, D., Joarder, F., Morimoto, V., Sprague, C., Yamashita, D., Cady, N., Rivera-Eschright, N., Kirchhoff, P., Morales Gomez, B., Adducci, J., Goncharova, A., Hox, S.H., Petrovitch, H., Matwichyna, M., Jenkins, V., Broadwater, L., Ishii, R.R., Bermudez, N.O., Hsia, D.S., Cefalu, W.T., Greenway, F.L., Waguespack, C., King, E., Fry, G., Dragg, A., Gildersleeve, B., Arceneaux, J., Haynes, N., Thomassie, A., Pavlionis, M., Bourgeois, B., Hazlett, C., Henry, R., Boeder, S., Pettus, J., Diaz, E., Garcia-Acosta, D., Maggs, S., DeLue, C., Stallings, A., Castro, E., Hernandez, S., Krakoff, J., Curtis, J.M., Killean, T., Khalid, M., Joshevama, E., Diaz, E., Martin, D., Tsingine, K., Karshner, T., Albu, J., Pi-Sunyer, F.X., Frances, S., Maggio, C., Ellis, E., Bastawrose, J., Gong, X., Banerji, M.A., August, P., Lee, M., Lorber, D., Brown, N.M., Josephson, D.H., Thomas, L.L., Tsovian, M., Cherian, A., Jacobson, M.H., Mishko, M.M., Kirkman, M.S., Buse, J.B., Diner, J., Dostou, J., Machineni, S., Young, L., Bergamo, K., Goley, A., Kerr, J., Largay, J.F., Guarda, S., Cuffee, J., Culmer, D., Fraser, R., Almeida, H., Coffer, S., Debnam, E., Kiker, L., Morton, S., Josey, K., Fuller, G., Garvey, W.T., Cherrington, A.L., Dyer, D., Lawson, M.C.R., Griffith, O., Agne, A., McCullars, S., Cohen, R.M., Craig, J., Rogge, M.C., Burton, K., Kersey, K., Wilson, C., Lipp, S., Vonder Meulen, M.B., Adkins, C., Onadeko, T., Rasouli, N., Baker, C., Schroeder, E., Razzaghi, M., Lyon, C., Penaloza, R., Underkofler, C., Lorch, R., Douglass, S., Steiner, S., Sivitz, W.I., Cline, E., Knosp, L.K., McConnell, J., Lowe, T., Herman, W.H., Pop-Busui, R., Martin, C., Waltje, A., Katona, A., Goodhall, L., Eggleston, R., Kuo, S., Bojescu, S., Bule, S., Kessler, N., LaSalle, E., Whitley, K., Seaquist, E.R., Bantle, A., Harindhanavudhi, T., Kumar, A., Redmon, B., Bantle, J., Coe, M., Mech, M., Taddese, A., Lesne, L., Smith, S., Kuechenmeister, L., Shivaswamy, V., Burbach, S., Rodriguez, M.G., Seipel, K., Alfred, A., Morales, A.L., Eggert, J., Lord, G., Taylor, W., Tillson, R., Adolphe, A., Burge, M., Duran-Valdez, E., Martinez, J., Bancroft, A., Kunkel, S., Ali Jamaleddin Ahmad, F., Hernandez McGinnis, D., Pucchetti, B., Scripsick, E., Zamorano, A., DeFronzo, R.A., Cersosimo, E., Abdul-Ghani, M., Triplitt, C., Juarez, D., Mullen, M., Garza, R.I., Verastiqui, H., Wright, K., Puckett, C., Raskin, P., Rhee, C., Abraham, S., Jordan, L.F., Sao, S., Morton, L., Smith, O., Osornio Walker, L., Schnurr-Breen, L., Ayala, R., Kreymer, R.B., Sturgess, D., Kahn, S.E., Alarcon-Casas Wright, L., Boyko, E.J., Tsai, E.C., Trence, D.L., Trikudanathan, S., Fattaleh, B.N., Montgomery, B.K., Atkinson, K.M., Kozedub, A., Concepcion, T., Moak, C., Prikhodko, N., Rhothisen, S., Elasy, T.A., Martin, S., Shackelford, L., Goidel, R., Hinkle, N., Lovell, C., Myers, J., Lipps Hogan, J., McGill, J.B., Salam, M., Schweiger, T., Kissel, S., Recklein, C., Clifton, M.J., Tamborlane, W., Camp, A., Gulanski, B., Pham, K., Alguard, M., Gatcomb, P., Lessard, K., Perez, M., Iannone, L., Magenheimer, E., Montosa, A., Cefalu, W.T., Fradkin, J., Burch, H.B., Bremer, A.A., Nathan, D.M., Lachin, J.M., Buse, J.B., Kahn, S.E., Larkin, M.E., Tiktin, M., Wexler, D., Burch, H.B., Bremer, A.A., Lachin, J.M., Bebu, I., Butera, N., Buys, C.J., Fagan, A., Gao, Y., Gramzinski, M.R., Hall, S.D., Kazemi, E., Legowski, E., Liu, H., Suratt, C., Tripputi, M., Arey, A., Backman, M., Bethepu, J., Lund, C., Mangat Dhaliwal, P., McGee, P., Mesimer, E., Ngo, L., Steffes, M., Seegmiller, J., Saenger, A., Arends, V., Gabrielson, D., Conner, T., Warren, S., Day, J., Huminik, J., Soliman, E.Z., Zhang, Z.M., Campbell, C., Hu, J., Keasler, L., Hensley, S., Li, Y., Herman, W.H., Kuo, S., Martin, C., Waltje, A., Mihalcea, R., Min, D.J., Perez-Rosas, V., Prosser, L., Resnicow, K., Ye, W., Shao, H., Zhang, P., Luchsinger, J., Sanchez, D., Assuras, S., Groessl, E., Sakha, F., Chong, H., Hillery, N., Abdouch, I., Bahtiyar, G., Brantley, P., Broyles, F.E., Canaris, G., Copeland, P., Craine, J.J., Fein, W.L., Gliwa, A., Hope, L., Lee, M.S., Meiners, R., Meiners, V., O’Neal, H., Park, J.E., Sacerdote, A., Sledge Jr, E., Soni, L., Steppel-Reznik, J., and Turchin, A.

Published
2024
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9. 393 Harnessing the potential of transcriptional adaptation as a mechanism for rare Amyotrophic lateral sclerosis

Author

Adriana Morales Gomez, Nathan Staff, and Stephen C. Ekker

Subjects
Medicine
Abstract

OBJECTIVES/GOALS: Transcriptional adaptation is a phenomenon in which a mutation in one gene leads to the genetic compensation of another homogenous gene. Understanding the mechanism of transcriptional adaptation may contribute to an explanation for variation in clinical manifestations of rare Amyotrophic lateral sclerosis patient phenotypes. METHODS/STUDY POPULATION: The presence of a premature termination codon triggers transcriptional activation. Therefore, we utilized CRISPR-Cas9 tool to generate a premature termination codon in CHCHD10 gene in multiple types of cells, including induced pluripotent stem cells derived from patient samples with known CHCHD10 mutations causative for Amyotrophic lateral sclerosis. CRISPR-Cas9 tool was delivered via ribonucleoprotein electroporation and transfect cell’s DNA was sequenced to validate gene editing. To confirm transcriptional adaption, changes in levels of protein and gene expression will be measured via immunoblot and quantification of CHCHD10 and CHCHCD2 from whole cells lysates of the edited cells. RESULTS/ANTICIPATED RESULTS: We anticipate that CHCHD2 transcriptional adaptation can functionally compensate for the locus loss of function of CHCHD10. This mechanism of transcriptional adaptation may contribute to an explanation for variation in clinical manifestations of patient phenotypes. DISCUSSION/SIGNIFICANCE: Our approach would advance discovery science towards by exploring transcriptional adaptation mechanism in humans, which can lead to novel therapies for rare Amyotrophic lateral sclerosis, such as CHCHD10.

Published
2024
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10. Burnout and Self-Perceived Stress in Workers in Essential Services after the Impact of Hurricanes Irma and Maria

Author

Morales-Gomez, Edline M., Torres-Montalvo, Keishla M., Heredia-Morales, Manuel, Rodriguez-Torres, Jessica, Diaz-Reguero, Zulmarie J., Manso-Davila, Merry A., Rivera-Leon, Solaritza, Vega-Solis, Nicol S., Ortiz-Cordero, Samary, Ramos-Aponte, Kareliz, Rivera-Hernandez, Yaritza, Aulet-Gonzalez, Bianca L., Torres-Figueroa, Domingo, Pagan-Santiago, Nilsalin, Figueroa-Estepa, Leslie, Font-Rivera, Ana S., Padilla-Camacho, Bridgette, Ventura-Rosa, Monica, Rosario-Medina, Jeannette C., Jesus, Jose C. Salaman-De, Santiago-Diaz, Annette M., Millan-Perez, Liza I., Pena-Orellana, Marisol, and Rios-Motta, Ruth

Published
2022

11. Higher burden of cardiometabolic and socioeconomic risk factors in women with type 2 diabetes: an analysis of the Glycemic Reduction Approaches in Diabetes (GRADE) baseline cohort

Author

C Wright, C Sanders, C Wilson, L Tucker, S Jones, S Douglass, C Patel, A Kumar, S Smith, A Ghosh, C Adams, R Hill, D Martin, J Hu, M Lee, N Patel, O Smith, J Cook, J Day, M Jackson, G Riera, P McGee, J Park, J Jiménez, S Yang, A Carlson, C Martin, H Liu, Y Li, A Krol, K Wright, S Golden, A Sood, J Martinez, D Sanchez, K Burton, Y Gao, S Martin, O Sanchez, C DeSouza, M Johnson, L Estrada, A Jackson, J Higgins, K Martin, J Craig, A Kuhn, L Ngo, Deborah J Wexler, R Chatterjee, E Walker, J Kerr, W Taylor, J Lim, M Perez, R Henry, Vanita R Aroda, R Fraser, Cyrus Desouza, E King, C Campbell, J González, E Diaz, P Zhang, J Marks, S Abraham, A Ross, M Khalid, T Young, J Myers, J Barzilay, B Chambers, G Montes, C Jensen, J McConnell, R Nelson, L Prosser, S Morton, M Curtis, P Wilson, L Young, M Fürst, S Warren, C Newman, S Kuo, N Rasouli, A Werner, L Morton, A Ghazi, M Salam, F Ismail-Beigi, P Kringas, C Baker, E Ellis, A Cherian, L Holloway, M Madden, B Hollis, G Fuller, B Steiner, K Stokes, R Ayala, T Lowe, K Chu, S Durán, D Dyer, A Alfred, J Leger, Nicole M Butera, T Hamilton, J Costello, E Burgess, R Garg, A Maxwell, C Stevens, W Ye, T Tran, L Fischer, M Hurtado, H Schneier, C Lund, R Lorch, M Mullen, J Bantle, K Arnold, D Wexler, A TURCHIN, MS Lee, D Howard, J Tejada, S Hernandez, Tasma Harindhanavudhi, E Schroeder, K Pham, S Kunkel, A Fagan, G Lord, H CHONG, A Smiley, E Debnam, H Petrovitch, M Bäckman, B Kauffman, V Jenkins, B Cramer, JP Crandall, MD McKee, S Behringer-Massera, J Brown-Friday, E Xhori, K Ballentine-Cargill, H Estrella, S Gonzalez de la torre, J Lukin, LS Phillips, D Olson, M Rhee, TS Raines, J Boers, C Gullett, M Maher-Albertelli, R Mungara, L Savoye, CA White, F Morehead, S Person, M Sibymon, S Tanukonda, A Balasubramanyam, R Gaba, P Hollander, E Roe, P Burt, K Chionh, C Falck-Ytter, L Sayyed Kassem, M Tiktin, T Kulow, KA Stancil, J Iacoboni, MV Kononets, L Colosimo, R Goland, J Pring, L Alfano, C Hausheer, K Gumpel, A Kirpitch, JB Green, H AbouAssi, MN Feinglos, J English Jones, RP Zimmer, BM Satterwhite, K Evans Kreider, CR Thacker, CN Mariash, KJ Mather, A Lteif, V Pirics, D Aguillar, S Hurt, R Bergenstal, T Martens, J Hyatt, H Willis, W Konerza, K Kleeberger, R Passi, S Fortmann, M Herson, K Mularski, H Glauber, J Prihoda, B Ash, C Carlson, PA Ramey, E Schield, B Torgrimson-Ojerio, E Panos, S Sahnow, K Bays, K Berame, D Ghioni, J Gluth, K Schell, J Criscola, C Friason, S Nazarov, N Rassouli, R Puttnam, B Ojoawo, C Sanders-Jones, Z El-Haqq, A Kolli, J Meigs, A Dushkin, G Rocchio, M Yepes, H Dulin, M Cayford, A DeManbey, M Hillard, N Thangthaeng, L Gurry, R Kochis, E Raymond, V Ripley, V Aroda, A Loveland, M Hamm, HJ Florez, WM Valencia, S Casula, L Oropesa-Gonzalez, L Hue, AK Riccio Veliz, R Nieto-Martinez, M Gutt, A Ahmann, D Aby-Daniel, F Joarder, V Morimoto, C Sprague, D Yamashita, N Cady, N Rivera-Eschright, P Kirchhoff, B Morales Gomez, J Adducci, A Goncharova, SH Hox, M Matwichyna, NO Bermudez, L Broadwater, RR Ishii, DS Hsia, WT Cefalu, FL Greenway, C Waguespack, N Haynes, A Thomassie, B Bourgeois, C Hazlett, S Mudaliar, S Boeder, J Pettus, D Garcia-Acosta, S Maggs, C DeLue, E Castro, J Krakoff, JM Curtis, T Killean, E Joshevama, K Tsingine, T Karshner, J Albu, FX Pi-Sunyer, S Frances, C Maggio, J Bastawrose, X Gong, MA Banerji, D Lorber, NM Brown, DH Josephson, LL Thomas, M Tsovian, MH Jacobson, MM Mishko, MS Kirkman, JB Buse, J Dostou, K Bergamo, A Goley, JF Largay, S Guarda, J Cuffee, D Culmer, H Almeida, S Coffer, L Kiker, K Josey, WT Garvey, A Agne, S McCullars, RM Cohen, MC Rogge, K Kersey, S Lipp, MB Vonder Meulen, C Underkofler, S Steiner, E Cline, WH Herman, R Pop-Busui, MH Tan, A Waltje, A Katona, L Goodhall, R Eggleston, K Whitley, S Bule, N Kessler, E LaSalle, ER Seaquist, A Bantle, T Harindhanavudhi, B Redmon, M Coe, M Mech, A Taddese, L Lesne, L Kuechenmeister, V Shivaswamy, AL Morales, K Seipel, J Eggert, R Tillson, DS Schade, A Adolphe, M Burge, E Duran-Valdez, P August, MG Rodriguez, O Griffith, A Naik, Barbara I Gulanski, Heidi Krause-Steinrauf, Judith H Lichtman, Jennifer B Green, Colleen E Suratt, Hiba AbouAssi, Andrew J Ahmann, E Gonzalez Hattery, A Ideozu, G McPhee, SA Khan, JB Kimpel, HM Ismail, ME Larkin, M Magee, A Ressing, L Manandhar, F Mwicigi, V Lagari-Libhaber, A Cuadot, YJ Kendal, B Veciana, G Fry, A Dragg, B Gildersleeve, J Arceneaux, M Pavlionis, A Stallings, S Machineni, AL Cherrington, MCR Lawson, C Adkins, T Onadeko, M Razzaghi, C Lyon, R Penaloza, WI Sivitz, LK Knosp, S Bojescu, S Burbach, A Bancroft, FA Jamaleddin Ahmad, D Hernandez McGinnis, B Pucchetti, E Scripsick, A Zamorano, RA DeFronzo, E Cersosimo, M Abdul-Ghani, C Triplitt, D Juarez, RI Garza, H Verastiqui, C Puckett, P Raskin, C Rhee, LF Jordan, S Sao, L Osornio Walker, L Schnurr-Breen, RB Kreymer, D Sturgess, KM Utzschneider, SE Kahn, L Alarcon-Casas Wright, EJ Boyko, EC Tsai, DL Trence, S Trikudanathan, BN Fattaleh, BK Montgomery, KM Atkinson, A Kozedub, T Concepcion, C Moak, N Prikhodko, S Rhothisen, TA Elasy, L Shackelford, R Goidel, N Hinkle, C Lovell, J Lipps Hogan, JB McGill, T Schweiger, S Kissel, C Recklein, MJ Clifton, W Tamborlane, A Camp, B Gulanski, SE Inzucchi, M Alguard, P Gatcomb, K Lessard, L Iannone, A Montosa, E Magenheimer, J Fradkin, HB Burch, AA Bremer, DM Nathan, JM Lachin, H Krause-Steinrauf, N Younes, I Bebu, N Butera, CJ Buys, MR Gramzinski, SD Hall, E Kazemi, E Legowski, C Suratt, M Tripputi, A Arey, J Bethepu, P Mangat Dhaliwal, E Mesimer, M Steffes, J Seegmiller, A Saenger, V Arends, D Gabrielson, T Conner, J Huminik, A Scrymgeour, EZ Soliman, Y Pokharel, ZM Zhang, L Keasler, S Hensley, R Mihalcea, DJ Min, V Perez-Rosas, K Resnicow, H Shao, J Luchsinger, S Assuras, E Groessl, F Sakha, N Hillery, BM Everett, I Abdouch, G Bahtiyar, P Brantley, FE Broyles, G Canaris, P Copeland, JJ Craine, WL Fein, A Gliwa, L Hope, R Meiners, V Meiners, H O’Neal, JE Park, A Sacerdote, E Sledge, L Soni, J Steppel-Reznik, B Brooks-Worrell, CS Hampe, JP Palmer, A Shojaie, L Doner Lotenberg, JM Gallivan, and DM Tuncer

Subjects
Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Introduction Type 2 diabetes mellitus (T2DM) is a powerful risk factor for cardiovascular disease (CVD), conferring a greater relative risk in women than men. We sought to examine sex differences in cardiometabolic risk factors and management in the contemporary cohort represented by the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).Research design and methods GRADE enrolled 5047 participants (1837 women, 3210 men) with T2DM on metformin monotherapy at baseline. The current report is a cross-sectional analysis of baseline data collected July 2013 to August 2017.Results Compared with men, women had a higher mean body mass index (BMI), greater prevalence of severe obesity (BMI≥40 kg/m2), higher mean LDL cholesterol, greater prevalence of low HDL cholesterol, and were less likely to receive statin treatment and achieve target LDL, with a generally greater prevalence of these risk factors in younger women. Women with hypertension were equally likely to achieve blood pressure targets as men; however, women were less likely to receive ACE inhibitors or angiotensin receptor blockers. Women were more likely to be divorced, separated or widowed, and had fewer years of education and lower incomes.Conclusions This contemporary cohort demonstrates that women with T2DM continue to have a greater burden of cardiometabolic and socioeconomic risk factors than men, particularly younger women. Attention to these persisting disparities is needed to reduce the burden of CVD in women.Trial registration number ClinicalTrials.gov (NCT01794143)

Published
2023
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12. Individual and structural factors affecting recidivism : the role of prisoners, prisons and place in the Chilean context

Author

Morales Gomez, Ana Ivon, Medina-Ariza, Juan, and Koskinen, Johan

Subjects
300, Chilean prisons, Bayesian spatial analysis, Re-offending, Recidivism, Prison-specific effects
Abstract

Criminology has a long history of trying to understand why people reoffend. People that are released from prison offer us the opportunity study the conditions under which some individuals continue to commit crimes and others do not in great detail. Although research in the last years have incorporated the context as a source of influence on recidivism, much of the literature has focused on attributing the explanations solely on the level of the individuals themselves. Taking this individualistic perspective as my point of departure, I take some steps towards incorporating effects of the environment and aspects associated with social influence and learning in explaining why people re-offend (after being released from prisons). Studying the Chilean prison system, I first establish individual factors associated with recidivism, then account for prison environment and characteristics, to finally attempt at accounting for larger community effects. This was done by analysing data from a cohort of offenders who served sentences in Chilean prisons. Individual factors associated with time until recidivism were analysed using Event history models. Then, multilevel models were used to account for prison-specific effects: the exclusive contribution of prison to recidivism. Finally, hierarchical spatial models were used to analyse how space can be associated with varying levels of recidivism. In addition to the effects of individual characteristics, strong evidence of prison-specific effects was found, which implies that individual propensity towards recidivism is not independent of the prison where the sentence is served. In other words, differences in prison settings have the potential to impact on the individual likelihood of re-offending either by reducing or incrementing the individual risk. Likewise, evidence of spatial clustering of recidivism was also found, which indicates that recidivism has also a spatial component operating beyond the individuals' control. The main contribution of this thesis lies in demonstrating that recidivism implies a complex system of interdependence between different actors and institutions, which needs to be considered to understand recidivism in a larger context. These findings have profound theoretical and policy implications, as they imply that the responsibility for recidivism falls not only on the offenders themselves but also on the wider context of the justice system's institutions and society itself.

Published
2018

14. Structural and functional changes in the fungal community of plant detritus in an invaded Atlantic Forest

Author

Jaqueline Bail, Jose Alejandro Morales Gomez, Giselle Cristina de Oliveira Vaz, Wagner Antonio Chiba de Castro, and Rafaella Costa Bonugli-Santos

Subjects
Ascomycota, Basidiomycota, Iguaçu National Park, Litter decomposition, Tradescantia zebrina, Microbiology, QR1-502
Abstract

Abstract Background Changes in the fungal community in the litter decomposition by invasive plants can negatively impact nutrient cycling in natural ecosystems. One still does not know the dimension of this hypothesis, but apparently, it is not despicable. This study evaluated the assemblage composition of fungi during litter decomposition in areas of Atlantic Forest invaded or not invaded by Tradescantia zebrina using Illumina MiSeq and metabarcoding analysis. Results The invaded sample showed significantly higher richness and a difference in the species dominance than the invaded litter. Ascomycota was the first most abundant phylum in both areas. Even so, the dissimilarity between areas can be evidenced. The fungal from Basidiomycota were very representative in the non-invaded areas (ranged from an abundance of 43.29% in the non-invaded to 2.35% in the invaded sample). The genus Lepiota can indicate the primary functional group related to biomass degradation and showed the might difference about the invaded areas due to its essential reduction by the invader. In the invaded sample, there was a total absence of the endophyte-undefined saprotroph guild. Also, some genera not taxonomically characterized were eliminated in the invaded sample, revealing that the fungal biodiversity of areas has not yet been thoroughly characterized. Conclusions Hence, makes impossible the real interpretation of the invasive plant impact, showing the importance of continuing research on fungal biodiversity. It is important to emphasize that the replacement of the native species by T. zebrina may be responsible for the elimination of fungal groups that have not yet been identified.

Published
2022
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16. 288 Harnessing the potential of transcriptional adaptation as a mechanism for Amyotrophic lateral sclerosis

Author

Adriana Morales Gomez, Nathan Staff, and Stephen C. Ekker

Subjects
Medicine
Abstract

OBJECTIVES/GOALS: Understanding the mechanism of transcriptional adaptation may contribute to an explanation for variation in clinical manifestations of Amyotrophic lateral sclerosis patient phenotypes. METHODS/STUDY POPULATION: To examine transcriptional adaptation, we utilized gene editing tools in HT1080 cells and patient samples with known CHCHD10 mutations causative for Amyotrophic lateral sclerosis. Frameshift mutations were performed via CRISPR-Cas9. Ribonucleoprotein electroporation was used to transfect cells and DNA sequencing was conducted to validate gene editing. To validate transcriptional adaption, changes in levels of protein and gene expression will be measured via immunoblot and quantification of CHCHD10 and CHCHCD2 from whole cells lysates of the edited cells. RESULTS/ANTICIPATED RESULTS: We anticipate that CHCHD2 transcriptional adaptation can functionally compensate for the locus loss of function of CHCHD10. This mechanism of transcriptional adaptation may contribute to an explanation for variation in clinical manifestations of patient phenotypes. DISCUSSION/SIGNIFICANCE: Our approach would advance discovery science towards by exploring CHCHD10/2 transcriptional adaptation mechanism that can lead to novel therapies for rare Amyotrophic lateral sclerosis, such as CHCHD10-R15L.

Published
2023
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20. Refined Homology-Directed Repair Methodological Approaches of Donorguide, a Chimeric RNA: DNA tracrRNA.

Author

Morales Gomez, Adriana, Rai Thulung, Lucy, Daby, Camden L., Savage, Kaila S., Clark, Karl J., and Ekker, Stephen C.

Subjects
*RNA, *DNA, *BRACHYDANIO, *DNA insertion elements
Abstract

The use of single-stranded oligodeoxynucleotide (ssODN) along with CRISPR–Cas9-mediated double-strand breaks (DSB) is one of the most commonly deployed methods for introducing genetic alterations, but this approach has notable limitations. Recognizing this, we have developed a protocol article that provides a step-by-step process of donorguide, a covalent fusion of trans-activating CRISPR RNA (tracrRNA) and ssODN. Donorguide has the potential to enhance the introduction of specific genetic alterations (insertion, deletion, and substitution) at a DSB, improving homology-directed repair methods from zebrafish in vivo to human cells in vitro. We also explored and discuss the impact of increasing the length of donorguide homology arms in zebrafish. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Maximum power, ecological function and efficiency of an irreversible Carnot cycle. A cost and effectiveness optimization

Author

Aragon-Gonzalez, G, Canales-Palma, A., Leon-Galicia, A., and Morales-Gomez, J. R.

Subjects
Physics - Classical Physics, Physics - General Physics
Abstract

In this work we include, for the Carnot cycle, irreversibilities of linear finite rate of heat transferences between the heat engine and its reservoirs, heat leak between the reservoirs and internal dissipations of the working fluid. A first optimization of the power output, the efficiency and ecological function of an irreversible Carnot cycle, with respect to: internal temperature ratio, time ratio for the heat exchange and the allocation ratio of the heat exchangers; is performed. For the second and third optimizations, the optimum values for the time ratio and internal temperature ratio are substituted into the equation of power and, then, the optimizations with respect to the cost and effectiveness ratio of the heat exchangers are performed. Finally, a criterion of partial optimization for the class of irreversible Carnot engines is herein presented., Comment: 17 pages, 4 figures. Submitted to Energy Convers. Manage

Published
2007
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23. Shape of the OGTT glucose response curve: relationship with β-cell function and differences by sex, race, and BMI in adults with early type 2 diabetes treated with metformin

Author

C Wright, C Wilson, L Tucker, S Jones, S Douglass, C Patel, A Kumar, S Smith, C Adams, R Hill, D Martin, M Lee, N Patel, J Cook, M Jackson, G Riera, E González, J Park, S Yang, A Carlson, C Martin, A Krol, A Sood, J Martinez, C DeSouza, M Johnson, L Estrada, A Jackson, K Martin, SA Khan, J Craig, A Kuhn, Deborah J Wexler, R Chatterjee, J Kerr, W Taylor, R Henry, R Fraser, Kieren J Mather, M Larkin, E King, E Diaz, J Marks, A Ross, M Khalid, J Barzilay, B Chambers, G Montes, C Jensen, J McConnell, R Nelson, S Morton, M Curtis, P Wilson, L Young, M Fürst, C Newman, S Kuo, N Rasouli, A Werner, A Ghazi, F Ismail-Beigi, P Kringas, C Baker, E Ellis, Philip Raskin, A Cherian, L Holloway, M Madden, B Hollis, G Fuller, B Steiner, K Stokes, T Lowe, K Chu, S Durán, A Alfred, John M Lachin, T Hamilton, J Costello, E Burgess, R Garg, C Stevens, T Tran, M Hurtado, H Schneier, R Lorch, M Mullen, J Bantle, K Arnold, D Wexler, Neda Rasouli, D Howard, J Tejada, S Hernandez, E Schroeder, S Kunkel, G Lord, A Smiley, E Debnam, H Petrovitch, B Kauffman, V Jenkins, B Cramer, Kristina M Utzschneider, Naji Younes, Joshua I Barzilay, Mary Ann Banerji, Robert M Cohen, Erica V Gonzalez, Faramarz Ismail-Beigi, Steven E Kahn, JP Crandall, MD McKee, S Behringer-Massera, J Brown-Friday, E Xhori, K Ballentine-Cargill, H Estrella, S Gonzalez de la torre, J Lukin, LS Phillips, D Olson, M Rhee, TS Raines, J Boers, C Gullett, M Maher-Albertelli, R Mungara, L Savoye, CA White, F Morehead, S Person, M Sibymon, S Tanukonda, A Balasubramanyam, R Gaba, P Hollander, E Roe, P Burt, K Chionh, C Falck-Ytter, L Sayyed Kassem, M Tiktin, T Kulow, KA Stancil, J Iacoboni, MV Kononets, G McPhee AMaxwell, L Colosimo, R Goland, J Pring, L Alfano, C Hausheer, K Gumpel, A Kirpitch, JB Green, H AbouAssi, MN Feinglos, J English Jones, RP Zimmer, BM Satterwhite, K Evans Kreider, CR Thacker, CN Mariash, KJ Mather, A Lteif, V Pirics, D Aguillar, S Hurt, R Bergenstal, T Martens, J Hyatt, H Willis, W Konerza, K Kleeberger, R Passi, S Fortmann, M Herson, K Mularski, H Glauber, J Prihoda, B Ash, C Carlson, PA Ramey, E Schield, B Torgrimson-Ojerio, E Panos, S Sahnow, K Bays, K Berame, D Ghioni, J Gluth, K Schell, J Criscola, C Friason, S Nazarov, N Rassouli, R Puttnam, B Ojoawo, C Sanders-Jones, Z El-Haqq, A Kolli, J Meigs, A Dushkin, G Rocchio, M Yepes, H Dulin, M Cayford, A DeManbey, M Hillard, N Thangthaeng, L Gurry, R Kochis, E Raymond, V Ripley, V Aroda, Ann Ressing, A Loveland, M Hamm, F Mofor, HJ Florez, WM Valencia, S Casula, L Oropesa-Gonzalez, L Hue, AK Riccio Veliz, R Nieto-Martinez, M Gutt, A Ahmann, D Aby-Daniel, F Joarder, V Morimoto, C Sprague, D Yamashita, N Cady, N Rivera-Eschright, P Kirchhoff, B Morales Gomez, J Adducci, A Goncharova, SH Hox, M Matwichyna, NO Bermudez, L Broadwater, RR Ishii, DS Hsia, WT Cefalu, FL Greenway, C Waguespack, N Haynes, A Thomassie, B Bourgeois, C Hazlett, S Mudaliar, S Boeder, J Pettus, D Garcia-Acosta, S Maggs, C DeLue, E Castro, J Krakoff, JM Curtis, T Killean, E Joshevama, K Tsingine, T Karshner, J Albu, FX Pi-Sunyer, S Frances, C Maggio, J Bastawrose, X Gong, MA Banerji, D Lorber, NM Brown, DH Josephson, LL Thomas, M Tsovian, MH Jacobson, MM Mishko, MS Kirkman, JB Buse, J Dostou, K Bergamo, A Goley, JF Largay, S Guarda, J Cuffee, D Culmer, H Almeida, S Coffer, L Kiker, K Josey, WT Garvey, A Cherrington, D Golson, MC Robertson, A Agne, S McCullars, RM Cohen, MC Rogge, K Kersey, S Lipp, MB Vonder Meulen, C Underkofler, S Steiner, W Sivitz, E Cline, L Knosp, WH Herman, R Pop-Busui, MH Tan, A Waltje, A Katona, L Goodhall, R Eggleston, K Whitley, S Bule, N Kessler, E LaSalle, ER Seaquist, A Bantle, T Harindhanavudhi, B Redmon, M Coe, M Mech, A Taddese, L Lesne, L Kuechenmeister, V Shivaswamy, AL Morales, K Seipel, J Eggert, R Tillson, DS Schade, A Adolphe, M Burge, E Duran-Valdez, P August, MG Rodriguez, JB Kimpel, and O Griffith

Subjects
Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Introduction The shape of the glucose curve during an oral glucose tolerance test (OGTT) reflects β-cell function in populations without diabetes but has not been as well studied in those with diabetes. A monophasic shape has been associated with higher risk of diabetes, while a biphasic pattern has been associated with lower risk. We sought to determine if phenotypic or metabolic characteristics were associated with glucose response curve shape in adults with type 2 diabetes treated with metformin alone.Research design and methods This is a cross-sectional analysis of 3108 metformin-treated adults with type 2 diabetes diagnosed

Published
2021
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24. 320 Genetic Compensation as a mechanism underlying patients with Rare ALS

Author

Adriana Morales Gomez, Nathan Staff, and Stephen C. Ekker

Subjects
Medicine
Abstract

OBJECTIVES/GOALS: Rare mutations in CHCHD10 gene are found in 1% of patients with familial Amyotrophic lateral sclerosis (ALS). The overall goal of this study is to utilize induced pluripotent stem cells (iPSCs) as an in vitro model organism for rare ALS variants to evaluate the mechanism of transcription adaptation of CHCHD10/2 as a potential therapeutic. METHODS/STUDY POPULATION: Point mutations on normal iPSCs was performed via Donorguide CRISPR/Cas9. The single stranded RNA/DNA donors contain genetic alterations of CHCHD10: Pro12Ser, Arg15Leu, Pro23Leu, Pro34Ser, Ser59Leu, Gly66Val, Pro80Leu, Tyr92Cys and Gln102His. Ribonucleoprotein electroporation was used to transfect iPSCs and DNA sequencing was used to validate gene editing. To validate transcriptional adaption, changes in levels of protein and gene expression were measured via immunoblot and quantification of CHCHD10 and CHCHCD2 was performed from whole cells lysates of the edited iPSCs. RESULTS/ANTICIPATED RESULTS: We anticipate that CHCHD2 transcriptional adaptation can functionally compensate for the locus loss of function of CHCHD10. This mechanism of transcriptional adaptation may contribute to an explanation for variation in clinical manifestations of patient phenotypes. DISCUSSION/SIGNIFICANCE: This study supplies further evidence for genetic modification as a treatment option for diseases with point mutation causal or enabling mechanisms, including some variants of ALS. Future work will explore the gene-correction from an ALS patient with a known CHCHD10-R15L variant.

Published
2022
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25. Diurnal variation of NMDA receptor expression in the rat cerebral cortex is associated with traumatic brain injury damage

Author

Francisco Estrada-Rojo, Julio Morales-Gomez, Elvia Coballase-Urrutia, Marina Martinez-Vargas, and Luz Navarro

Subjects
Excitotoxicity, Circadian rhythm, Glutamate receptor, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390
Abstract

Abstract Objective Data from our laboratory suggest that recovery from a traumatic brain injury depends on the time of day at which it occurred. In this study, we examined whether traumatic brain injury -induced damage is related to circadian variation in N‐methyl‐d‐aspartate receptor expression in rat cortex. Results We confirmed that traumatic brain injury recovery depended on the time of day at which the damage occurred. We also found that motor cortex N‐methyl‐d‐aspartate receptor subunit NR1 expression exhibited diurnal variation in both control and traumatic brain injury-subjected rats. However, this rhythm is more pronounced in traumatic brain injury—subjected rats, with minimum expression in those injured during nighttime hours. These findings suggest that traumatic brain injury occurrence times should be considered in future clinical studies and when designing neuroprotective strategies for patients.

Published
2018
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28. 55564 Interactive mindfulness and dialogue sessions are integral components of research training.

Author

Kit Knier, Adriana Morales Gomez, Joanna Yang Yowler, Chris Pierret, and Linda M. Scholl

Subjects
Medicine
Abstract

ABSTRACT IMPACT: This work demonstrates the integration of interactive mindfulness and dialogue sessions in curricula is both desired by students and effective in conferring resilience, a protective factor that may aid in maintaining wellbeing of trainees interested in pursuing graduate studies in biomedical research and science. OBJECTIVES/GOALS: To support student futures in the field of biomedicine, Mayo Clinic Graduate School of Biological Sciences utilized digital platforms to deliver a summer research program in the summer of 2020. One goal of this program, in addition to scholastic outcomes and research experience, was to support and improve the wellbeing of college student participants. METHODS/STUDY POPULATION: Following the cancellation of in-person summer research programs, students were invited to attend a digital Summer Foundations in Research program. The 4-week program included 4 small group dialogue sessions led by trained facilitators and 4 large group mindfulness seminars followed with 3 Q/A style small group sessions. Surveys were delivered on days 1, 27, and 3 months following the program. Wellbeing measures included Brief Resilience, Perceived Stress, and Satisfaction with Life Scales. Students were prompted to indicate how worthwhile they found course components and comment on why they rated each component the way they did. Wellbeing results were assessed using paired t-tests with Bonferroni correction for multiple comparisons. Thematic analysis was used to interpret qualitative results. RESULTS/ANTICIPATED RESULTS: Students improved across all wellbeing measures at the program conclusion, including resilience (mean difference(SE) pre- to post-program +0.22(0.06) p=0.0007), perceived stress (-1.71(0.66) p=0.0116), and life satisfaction (+1.57(0.52) p=0.0037). Gains in resilience were maintained 3 months out (pre-program to 3 month survey +0.28(0.06) p

Published
2021
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29. 75202 The New Normal: A Virtual Summer Foundations in Research

Author

Adriana Morales Gomez, Kit Knier, Joanna Yang Yowler, Chris Pierret, and Linda M. Scholl

Subjects
Medicine
Abstract

ABSTRACT IMPACT: The Summer Foundation on Research gave undergraduate students the opportunity to do research despite the new normal - COVID-19 pandemic. OBJECTIVES/GOALS: The COVID-19 pandemic prevented domestic and international undergraduate students from attending in-person Mayo Clinic Summer Undergraduate Research Programs. Mayo decided to redesign this program as a virtual, 4-week Summer Foundations in Research (SFIR) program. The goal of this program was to give students a scientific research experience. METHODS/STUDY POPULATION: The SFIR included an Introduction to Experimental Design, Dialogue methodology for communicating science, scientific mentoring, asynchronous online modules and a Resiliency component. Evaluations of the program were undertaken to gather feedback for program improvement and to assess the educational and mental health impact on participants. These evaluations asked student to rate each section of the program. Additionally, students were encouraged to provide their own comments and feedback. Statistical analysis of quantitative data was performed using excel. The qualitative data was studied using the identification, analysis and interpretation of patterns method per the student’s comments on each of the questions addressed in the survey. RESULTS/ANTICIPATED RESULTS: These evaluations revealed positive outcomes across program components: 66% of the participants found the Resiliency component extremely worthwhile, 80% of participants liked the experimental design and 70% liked the educational courses. Qualitative data showed that mentor/mentee interactions were highly valued, and both participants and faculty suggested increasing the amount of time devoted to these interactions. Small group discussions gave students the opportunity to get to know other peers and encouraged further discussions about science and the community. Participants suggested minor improvements to the program, such as re-creating the online modules specific for undergraduate students, increasing 1-to-1 and small group’s discussion, and increasing the length of the program. DISCUSSION/SIGNIFICANCE OF FINDINGS: Despite the quick pivot of the SFIR program, the re-design and new format supported the development of participants’ resilience skills and training as future scientists during a particularly challenging time. Mayo is committed to continuing this program as an early step in a pathway to careers in research.

Published
2021
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30. Diseño de una Estacion de Bomberos para el Municipio de Villanueva, Santander

Author

Morales Gomez, Johan Nicolas and Sevilla Torres, Diana Carolina

Subjects
Estación de bomberos, Firefighterstatus, Response time, Emergencia, Implementation, arquitectura de interiores, Emergency, cuerpo de bomberos, Implantación, Functionalism, Funcionalismo, Tiempo de respuesta, bomberos - requisitos residenciales
Abstract

Una estación de bomberos coordina, apoya y gestiona la técnica operativamente a los cuerpos de bomberos para la atención de las distintas emergencias relacionadas con la gestión integral del riesgo contra incendios y los distintos preparativos y atenciones para el rescate en la totalidad de las modalidades e incidentes con materiales peligrosos. El municipio de Villanueva, en la actualidad no cuenta con una organización espacial la cual indique el crecimiento de la población, por lo tanto, hoy en día se han tomado medidas para ello, una de las problemáticas más evidente es que el municipio tiene una gran afectación con referente a de las viviendas, existiendo una gran posibilidad de que se ocasione un incendio debido a que usualmente se incendian hasta dos casas por mes, ya que el 40% de habitantes cuenta con viviendas vulnerables al fuego; el último incendio fue en el año 2017. Teniendo en cuenta lo planteado anteriormente es necesario resaltar la importancia de este proyecto ya que no se centra exclusivamente el estudio físico de la construcción de la estación de bomberos sino también del beneficio que este trae consigo. A fire station coordinates, supports and manages the technique operationally to the fire departments for the attention of the different emergencies related to the integral management of the risk against fires and the different preparations and attention for the rescue in all the modalities and incidents with hazardous materials. The municipality of Villanueva currently does not have a spatial organization which indicates the growth of the population, therefore, today measures have been taken for it, one of the most evident problems is that the municipality has a large affectation with regard to the houses, with a great possibility of causing a fire because up to two houses usually burn down per month, since 40% of the inhabitants have houses vulnerable to fire; the last fire was in 2017. Taking into account what was stated above, it is necessary to highlight the importance of this project since it does not focus exclusively on the physical study of the construction of the fire station but also on the benefit that it brings. Arquitecto http://www.ustabuca.edu.co/ustabmanga/presentacion Pregrado

Published
2022

31. DNA metabarcoding of the leachate microbiota from sanitary landfill: potential for bioremediation process

Author

João Victor Fonseca Moreira, Rafaella Costa Bonugli-Santos, Michel Rodrigo Zambrano Passarini, and Jose Alejandro Morales Gomez

Subjects
biology, Firmicutes, Microbiota, Bacteroidetes, General Medicine, Solid Waste, biology.organism_classification, Biochemistry, Microbiology, Waste Disposal Facilities, Biodegradation, Environmental, Bioremediation, Microbial ecology, Microbial population biology, Environmental chemistry, Genetics, DNA Barcoding, Taxonomic, Leachate, Proteobacteria, Synergistetes, Molecular Biology, Water Pollutants, Chemical
Abstract

Leachate generation contains a variety of toxic compounds, and is a major problem for municipal solid waste (MSW). Microbial profile knowledge is essential to new alternatives and improvements in current treatments of these effluents. In this respect, the microbial community in the leachate from the sanitary landfill of the city of Foz do Iguaçu was analyzed. The 16S rDNA metabarcoding suggested the dominance of fermenting bacteria belonging to Firmicutes phylum, followed by Proteobacteria, Bacteroidetes, and Synergistetes. The most abundant genera were Sedimentibacter, Vulcanibacillus, and Anaerovorax. However, 60% of amplicon sequence variants (ASVs) were not classified taxonomically. In addition, an expressive abundance was attributed to the superphylum known as PVC group, little studied and with unknown scientific potential. The leachate acidogenic phase was masked in the chemical and physical analyzes. Nevertheless, it was evidenced in the metabarcoding methodology. No specifically methanogenic group was detected in significant abundance. Therefore, from bacterial community identification, a bioremediation process can be designed. Enriched culture media can be developed and targeted to the recovery of specific groups which may be involved in leachate biodegradation. What is more, the results expand the knowledge of bacterial diversity, especially from the presence of unknown genera in this habitat.

Published
2021
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33. Defying expectations:Can we identify neighbourhoods with 'other than expected' developmental outcomes?

Author

Morales-Gomez, Ana and McVie, Susan

Subjects
violence, vulnerabilities, administrative data, repeat victimisation, mixture models, crime
Abstract

ObjectiveThe aim of this project is to analyse temporal patterns of repeat violent victimisation (RVV) in Scotland using administrative data and explore the extent to which these patterns are associated with underlying health vulnerabilities (related to mental health and problematic alcohol and/or drug use) and vary by individual socio-demographic characteristics.ApproachViolence in Scotland, and especially RVV, is a ‘key public health priority’. However, very little is known about the link between violence and other health vulnerabilities at an individual level, which may be useful in informing prevention approaches. This paper uses data on violence-related ambulance call-outs linked to hospital records containing information on wider health vulnerabilities. We use survival mixture models to identify and characterise population sub-groups, based on time to repeated violent episodes and explore how different health-related factors are associated with RVV and how this varies across sub-populations.ResultsWe identify two classes of RVV with two distinct survival trajectories: a ‘low vulnerability’ class and a ‘high vulnerability’ class. People in the high vulnerability class experienced RVV more quickly and were more likely to have underlying mental health conditions and/or problematic drug or alcohol use than those in the low vulnerability class. The association between socio-demographic characteristics and RVV differed across the two classes, with significant inequality in RVV for high-risk individuals between those in the most and the least affluent communities. The findings suggest that the first 6 months after the index event is a critical period of RVV for people in the high-risk group, but there may be different exposure mechanisms for different types of victims.ConclusionBetter use of administrative data from health sources could help improve our understanding and identification of repeat victims of violence. The ability to identify whether victims are likely to be ‘high-risk’ or ‘low-risk’ could inform the design of focused strategic approaches and interventions aimed at reducing repeat violent victimization.

Published
2022

34. Clinical and Metabolic Characterization of Adults With Type 2 Diabetes by Age in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) Cohort

Author

Aroda, Vanita R., Krause-Steinrauf, Heidi, Kazemi, Erin J., Buse, John B., Gulanski, Barbara I., Florez, Hermes J., Ahmann, Andrew J., Loveland, Amy, Kuhn, Alexander, Lonier, Jacqueline Y., Wexler, Deborah J., Crandall, J.P., McKee, M.D., Behringer-Massera, S., Brown-Friday, J., Xhori, E., Ballentine-Cargill, K., Duran, S., Estrella, H., Gonzalez de la torre, S., Lukin, J., Phillips, L.S., Burgess, E., Olson, D., Rhee, M., Wilson, P., Raines, T.S., Boers, J., Costello, J., Maher-Albertelli, M., Mungara, R., Savoye, L., White, C.A., Gullett, C., Holloway, L., Morehead, F., Person, S., Sibymon, M., Tanukonda, S., Adams, C., Ross, A., Balasubramanyam, A., Gaba, R., Gonzalez Hattery, E., Ideozu, A., Jimenez, J., Montes, G., Wright, C., Hollander, P., Roe, E., Jackson, A., Smiley, A., Burt, P., Estrada, L., Chionh, K., Ismail-Beigi, F., Falck-Ytter, C., Sayyed Kassem, L., Sood, A., Tiktin, M., Kulow, T., Newman, C., Stancil, K.A., Cramer, B., Iacoboni, J., Kononets, M.V., Sanders, C., Tucker, L., Werner, A., Maxwell, A., McPhee, G., Patel, C., Colosimo, L., Krol, A., Goland, R., Pring, J., Alfano, L., Kringas, P., Hausheer, C., Tejada, J., Gumpel, K., Kirpitch, A., Schneier, H., Green, J.B., AbouAssi, H., Chatterjee, R., Feinglos, M.N., English Jones, J., Khan, S.A., Kimpel, J.B., Zimmer, R.P., Furst, M., Satterwhite, B.M., Thacker, C.R., Evans Kreider, K., Mariash, C.N., Mather, K.J., Ismail, H.M., Lteif, A., Mullen, M., Hamilton, T., Patel, N., Riera, G., Jackson, M., Pirics, V., Aguillar, D., Howard, D., Hurt, S., Bergenstal, R., Carlson, A., Martens, T., Johnson, M., Hill, R., Hyatt, J., Jensen, C., Madden, M., Martin, D., Willis, H., Konerza, W., Yang, S., Kleeberger, K., Passi, R., Fortmann, S., Herson, M., Mularski, K., Glauber, H., Prihoda, J., Ash, B., Carlson, C., Ramey, P.A., Schield, E., Torgrimson-Ojerio, B., Arnold, K., Kauffman, B., Panos, E., Sahnow, S., Bays, K., Berame, K., Cook, J., Ghioni, D., Gluth, J., Schell, K., Criscola, J., Friason, C., Jones, S., Nazarov, S., Barzilay, J., Rassouli, N., Puttnam, R., Ojoawo, B., Nelson, R., Curtis, M., Hollis, B., Sanders-Jones, C., Stokes, K., El-Haqq, Z., Kolli, A., Tran, T., Wexler, D., Larkin, M., Meigs, J., Chambers, B., Dushkin, A., Rocchio, G., Yepes, M., Steiner, B., Dulin, H., Cayford, M., Chu, K., DeManbey, A., Hillard, M., Martin, K., Thangthaeng, N., Gurry, L., Kochis, R., Raymond, E., Ripley, V., Stevens, C., Park, J., Aroda, V., Ghazi, A., Magee, M., Ressing, Ann, Loveland, A., Hamm, M., Hurtado, M., Kuhn, A., Leger, J., Manandhar, L., Sanchez, O., Young, T., Mofor, F., Garg, R., Lagari-Libhaber, V., Florez, H.J., Valencia, W.M., Marks, J., Casula, S., Oropesa-Gonzalez, L., Hue, L., Cuadot, A., Nieto-Martinez, R., Riccio Veliz, A.K., Gutt, M., Kendal, Y.J., Veciana, B., Ahmann, A., Aby-Daniel, D., Joarder, F., Morimoto, V., Sprague, C., Yamashita, D., Cady, N., Rivera-Eschright, N., Kirchhoff, P., Morales Gomez, B., Adducci, J., Goncharova, A., Hox, S.H., Petrovitch, H., Matwichyna, M., Jenkins, V., Broadwater, L., Ishii, R.R., Bermudez, N.O., Hsia, D.S., Cefalu, W.T., Greenway, F.L., Waguespack, C., King, E., Fry, G., Dragg, A., Gildersleeve, B., Arceneaux, J., Haynes, N., Thomassie, A., Pavlionis, M., Bourgeois, B., Hazlett, C., Mudaliar, S., Henry, R., Boeder, S., Pettus, J., Diaz, E., Garcia-Acosta, D., Maggs, S., DeLue, C., Stallings, A., Castro, E., Hernandez, S., Krakoff, J., Curtis, J.M., Killean, T., Khalid, M., Joshevama, E., Tsingine, K., Karshner, T., Albu, J., Pi-Sunyer, F.X., Frances, S., Maggio, C., Ellis, E., Bastawrose, J., Gong, X., Banerji, M.A., August, P., Lee, M., Lorber, D., Brown, N.M., Josephson, D.H., Thomas, L.L., Tsovian, M., Cherian, A., Jacobson, M.H., Mishko, M.M., Kirkman, M.S., Buse, J.B., Dostou, J., Machineni, S., Young, L., Bergamo, K., Goley, A., Kerr, J., Largay, J.F., Guarda, S., Cuffee, J., Culmer, D., Fraser, R., Almeida, H., Coffer, S., Debnam, E., Kiker, L., Morton, S., Josey, K., Fuller, G., Garvey, W.T., Cherrington, A.L., Dyer, D., Lawson, M.C.R., Griffith, O., Agne, A., McCullars, S., Cohen, R.M., Craig, J., Rogge, M.C., Burton, K., Kersey, K., Wilson, C., Lipp, S., Vonder Meulen, M.B., Adkins, C., Onadeko, T., Rasouli, N., Baker, C., Schroeder, E., Razzaghi, M., Lyon, C., Penaloza, R., Underkofler, C., Lorch, R., Douglass, S., Steiner, S., Sivitz, W.I., Cline, E., Knosp, L.K., McConnell, J., Lowe, T., Herman, W.H., Pop-Busui, R., Tan, M.H., Martin, C., Waltje, A., Katona, A., Goodhall, L., Eggleston, R., Kuo, S., Bojescu, S., Bule, S., Kessler, N., LaSalle, E., Whitley, K., Seaquist, E.R., Bantle, A., Harindhanavudhi, T., Kumar, A., Redmon, B., Bantle, J., Coe, M., Mech, M., Taddese, A., Lesne, L., Smith, S., Desouza, C., Kuechenmeister, L., Shivaswamy, V., Burbach, S., Rodriguez, M.G., Seipel, K., Alfred, A., Morales, A.L., Eggert, J., Lord, G., Taylor, W., Tillson, R., Schade, D.S., Adolphe, A., Burge, M., Duran-Valdez, E., Martinez, J., Bancroft, A., Kunkel, S., Ali Jamaleddin Ahmad, F., Hernandez McGinnis, D., Pucchetti, B., Scripsick, E., Zamorano, A., DeFronzo, R.A., Cersosimo, E., Abdul-Ghani, M., Triplitt, C., Juarez, D., Garza, R.I., Verastiqui, H., Wright, K., Puckett, C., Raskin, P., Rhee, C., Abraham, S., Jordan, L.F., Sao, S., Morton, L., Smith, O., Osornio Walker, L., Schnurr-Breen, L., Ayala, R., Kreymer, R.B., Sturgess, D., Utzschneider, K.M., Kahn, S.E., Alarcon-Casas, L., Wright, L., Boyko, E.J., Tsai, E.C., Trence, D.L., Trikudanathan, S., Fattaleh, B.N., Montgomery, B.K., Atkinson, K.M., Kozedub, A., Concepcion, T., Moak, C., Prikhodko, N., Rhothisen, S., Elasy, T.A., Martin, S., Shackelford, L., Goidel, R., Hinkle, N., Lovell, C., Myers, J., Lipps Hogan, J., McGill, J.B., Salam, M., Schweiger, T., Kissel, S., Recklein, C., Clifton, M.J., Tamborlane, W., Camp, A., Gulanski, B., Inzucchi, S.E., Pham, K., Alguard, M., Gatcomb, P., Lessard, K., Perez, M., Iannone, L., Magenheimer, E., Montosa, A., Burch, H.B., Bremer, A.A., Fradkin, J., Nathan, D.M., Lachin, J.M., Krause-Steinrauf, H., Younes, N., Backman, M., Bebu, I., Butera, N., Buys, C.J., Fagan Murphy, A., Gao, Y., Ghosh, A., Gramzinski, M.R., Kazemi, E., Hall, S.D., Legowski, E., Suratt, C., Tripputi, M., Arey, A., Bethepu, J., Lund, C., Mangat Dhaliwal, P., McGee, P., Mesimer, E., Ngo, L., Steffes, M., Seegmiller, J., Saenger, A., Arends, V., Gabrielson, D., Conner, T., Warren, S., Day, J., Huminik, J., Scrymgeour, A., Soliman, E.Z., Pokharel, Y., Zhang, Z.M., Campbell, C., Hu, J., Keasler, L., Hensley, S., Li, Y., Mihalcea, R., Min, D.J., Perez-Rosas, V., Prosser, L., Resnicow, K., Ye, W., Shao, H., Zhang, P., Luchsinger, J., Sanchez, D., Assuras, S., Groessl, E., Sakha, F., Chong, H., Hillery, N., Everett, B.M., Abdouch, I., Bahtiyar, G., Brantley, P., Broyles, F.E., Canaris, G., Copeland, P., Craine, J.J., Fein, W.L., Gliwa, A., Hope, L., Lee, M.S., Meiners, R., Meiners, V., O’Neal, H., Park, J.E., Sacerdote, A., Sledge, E., Soni, L., Steppel-Reznik, J., Turchin, A., Brooks-Worrell, B., Hampe, C.S., Newgard, C.B., Palmer, J.P., Shojaie, A., Higgins, J., Fischer, L., Golden, S., Gonzalez, J., Naik, A., Walker, E., Doner Lotenberg, L., Gallivan, J.M., Lim, J., and Tuncer, D.M.

Subjects
Clinical Care/Education/Nutrition/Psychosocial Research
Abstract

OBJECTIVE: Differences in type 2 diabetes phenotype by age are described, but it is not known whether these differences are seen in a more uniformly defined adult population at a common early stage of care. We sought to characterize age-related clinical and metabolic characteristics of adults with type 2 diabetes on metformin monotherapy, prior to treatment intensification. RESEARCH DESIGN AND METHODS: In the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE), participants were enrolled who had type 2 diabetes duration

Published
2022

35. Muscle Energy Metabolism, Growth, and Meat Quality in Beef Cattle

Author

Jordan Wicks, Mariane Beline, Juan Fernando Morales Gomez, Santiago Luzardo, Saulo Luz Silva, and David Gerrard

Subjects
animals, growth, muscle, meat quality, beef, tenderness, color, Agriculture (General), S1-972
Abstract

World meat production must increase substantially to support current projections in population growth over the next 30 years. However, maximizing product quality remains a focus for many in the meat industry, as incremental increases in product quality often signal potential increases in segment profitability. Moreover, increases in meat quality also address concerns raised by an ever-growing affluent society demanding greater eating satisfaction. Production strategies and valued endpoints differ worldwide, though this makes the global marketing of meat challenging. Moreover, this variation in production schemes makes it difficult for the scientific community to understand precisely those mechanisms controlling beef quality. For example, some cattle are produced in low input, extensive, forage-based systems. In contrast, some producers raise cattle in more intensive operations where feeding programs are strategically designed to maximal growth rates and achieve significant fat deposition. Yet, others produce cattle that perform between these two extremes. Fresh meat quality, somewhat like the variation observed in production strategies, is perceived differently across the globe. Even so, meat quality is largely predicated on those characteristics visible at the retail counter, namely color and perceived texture and firmness. Once purchased, however, the eating experience is a function of flavor and tenderness. In this review, we attempt to identify a few areas where animal growth may impact postmortem energy metabolism and thereby alter meat quality. Understanding how animals grow and how this affects meat quality development is incumbent to all vested in the meat industry.

Published
2019
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36. Teaching Skills to Promote Clinical Reasoning in Early Basic Science Courses

Author

Elizondo-Omana, Rodrigo Enrique, Morales-Gomez, Jesus Alberto, and Morquecho-Espinoza, Orlando

Abstract

Basic and superior reasoning skills are woven into the clinical reasoning process just as they are used to solve any problem. As clinical reasoning is the central competence of medical education, development of these reasoning skills should occur throughout the undergraduate medical curriculum. The authors describe here a method of teaching reasoning skills in a clinical context during a human anatomy course. (Contains 3 tables.)

Published
2010
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38. Inequalities in the Quality and Governance of Urban, Public Green Spaces, Evidence from Deprived Neighborhoods in Queretaro, Mexico

Author

Claudia Abigail Morales Gomez, Karol Soria Yañez, and Mónica Ribeiro-Palacios

Subjects
Inequality, Health, Toxicology and Mutagenesis, media_common.quotation_subject, Corporate governance, Geography, Planning and Development, Urban sustainability, Management, Monitoring, Policy and Law, Sustainable environment, Urban planning, Component (UML), Key (cryptography), Quality (business), Business, Environmental planning, media_common
Abstract

Urban, public green spaces have become part of the worldwide urban planning agenda and form a key component of the quality of life, health, and sustainable environment. However, the benefits of the...

Published
2021
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39. Serum Phosphorylated Neurofilament Heavy Subunit Levels and its Association with the Risk for Catastrophic Injury in Thoroughbred Racehorses

Author

Irene Rojas-Núñez, Adriana Morales Gomez, Scott Palmer, and Hussni O. Mohammed

Subjects
Equine, Risk Factors, Case-Control Studies, Physical Conditioning, Animal, Intermediate Filaments, Animals, Enzyme-Linked Immunosorbent Assay, Horses
Abstract

Neurofilaments are structural proteins that are concentrated in the body and axons of neurons. Damage to the neurons or axons as a result of trauma or infectious diseases leads to the release of neurofilaments into blood and cerebrospinal fluid (CSF). This case-control study was carried out to compare serum levels of phosphorylated neurofilament heavy chain (pNF-H) between clinically healthy Thoroughbred (TB) horses and TB horses that suffered catastrophic musculoskeletal injuries (cMSI), and to investigate the correlation between putative risk factors and serum concentrations of pNF-H in injured horses. Blood samples were collected from clinically healthy horses and from horses that suffered cMSI. The concentration of pNF-H in serum samples was determined using the Phosphorylated Neurofilament H Sandwich enzyme-linked immunosorbent assay kit. A total of 343 horses were enrolled in the study (148 cases and 195 controls). The median serum concentration of pNF-H for controls was 0.0 ng/ml and for cases was 0.07 ng/ml. No significant difference was observed between the 2 groups in racing. The number of lifetime starts was correlated with serum pNF-H concentration in case horses. The serum concentration of pNF-H was higher in case horses that experienced cMSI while training than while racing. The number of lifetime starts is a proxy measure for several risk factors related to cumulative exercise load during the career of racehorses. Measurement of serum concentrations of pNF-H in TB racehorses does not support the hypothesis that subclinical neurologic injury or conditions are associated with catastrophic injury of TB racehorses.

Published
2022

40. Islet Autoimmunity is Highly Prevalent and Associated With Diminished β-Cell Function in Patients With Type 2 Diabetes in the Grade Study

Author

Brooks-Worrell, Barbara, Hampe, Christiane S., Hattery, Erica G., Palomino, Brenda, Zangeneh, Sahar Z., Utzschneider, Kristina, Kahn, Steven E., Larkin, Mary E., Johnson, Mary L., Mather, Kieren J., Younes, Naji, Rasouli, Neda, Desouza, Cyrus, Cohen, Robert M., Park, Jean Y., Florez, Hermes J., Valencia, Willy Marcos, Shojaie, Ali, Palmer, Jerry P., Balasubramanyam, Ashok, Crandall, Jill P., McKee, Melissa Diane, Brown-Friday, Janet, Xhori, Entila, Ballentine-Cargill, Keisha, Duran, Sally, Lukin, Jennifer, Beringher, Stephanie, Gonzalez de la Torre, Susana, Phillips, Lawrence, Burgess, Elizabeth, Olson, Darin, Rhee, Mary, Wilson, Peter, Raines, Tasha Stephanie, Costello, Julie, Gullett, Chona, Maher-Albertelli, Maxine, Morehead, Folayan, Mungara, Radhika, Person, Saranjit, Savoye, Louise, Sibymon, Mabil, Tanukonda, Sridhar, White, Carol Ann, Holloway, Leah, Adams, Cynthia, Ross, April, Gonzalez Hattery, Erica, Gaba, Ruchi, Montes, Graciela, Wright, Charlyne, Hollander, Priscilla, Roe, Erin, Uy, Analyn, Burt, Polly, Estrada, Lorie, Chionh, Kris, Ismail-Beigi, Faramarz, Falck-Ytter, Corinna, Sayyed Kassem, Laure, Sood, Ajay, Tiktin, Margaret, Cramer, Bethany, Iacoboni, Jacalyn, Kononets, Maria V., Kulow, Tanya, Newman, Cynthia, Stancil, Katherine A., Sanders, Cristina, Tucker, Lisa, Werner, Amanda, Krol, Adrienne, McPhee, Gloria, Patel, Christine, Colosimo, Linda, Goland, Robin, Pring, James, Kringas, Patricia, Tejada, Jessica, Hausheer, Camille, Schneier, Harvey, Gumpel, Kelly, Kirpitch, Amanda, Green, Jennifer B., AbouAssi, Hiba, Chatterjee, Ranee, Feinglos, Mark N., English Jones, Jennifer, Khan, Shubi A., Kimpel, Jeanne B., Zimmer, Ronna P., Furst, Mary, Satterwhite, Barbara M., Thacker, Connie, Evans Kreider, Kathryn, Lteif, Amale, Hamilton, Tonya, Patel, Nick, Riera, Gabriela, Jackson, Marcia, Pirics, Vivian, Howard, Devin, Aguillar, Danielle, Hurt, Sloan, Bergenstal, Richard, Carlson, Anders, Martens, Thomas, Johnson, Mary, Hill, Renae, Hyatt, Jamie, Jensen, Connie, Madden, Marcia, Martin, Dianna, Willis, Holly, Konerza, Wanda, Passi, Rebecca, Kleeberger, Kathleen, Fortmann, Stephen, Herson, Michael, Mularski, Karen, Glauber, Harry, Prihoda, James, Ash, Britt, Carlson, Christina, Ramey, Phyllis Anne, Schield, Emily, Torgrimson-Ojerio, Britta, Arnold, Kathy, Kauffman, Bryan, Panos, Elease, Sahnow, Samantha, Bays, Kristi, Cook, Jennifer, Gluth, Jennifer, Sasaki, Debra, Schell, Katrina, Criscola, Jennifer, Friason, Camille, Jones, Suzi, Nazarov, Sergey, Barzilay, Joshua, Rassouli, Negah, Puttnam, Rachel, Curtis, Michelle, Stokes, Kia, Hollis, Bonita, Sanders-Jones, Cynthia, Nelson, Roslin, El-Haqq, Zakiah, Kolli, Abby, Tran, Tu, Wexler, Deborah, Larkin, Mary, Meigs, James, Dushkin, Amy, Rocchio, Gianna, Chambers, Brittany, Yepes, Mike, Steiner, Barbara, Dulin, Hilary, Cayford, Melody, DeManbey, Andrea, Gurry, Lindsey, Hillard, Mallory, Martin, Kimberly, Stevens, Christine, Thangthaeng, Nopporn, Kochis, Raquel, Raymond, Elyse, Ripley, Valerie, Park, Jean, Aroda, Vanita, Ghazi, Adline, Loveland, Amy, Hurtado, Maria, Kuhn, Alexander, Mofor, Florence, Marks, Jennifer, Oropesa-Gonzalez, Lisset, Riccio Veliz, Ana K., Nieto-Martinez, Ramfis, Gutt, Miriam, Ahmann, Andrew, Aby-Daniel, Diana, Joarder, Farahnaz, Morimoto, Victoria, Sprague, Carol, Yamashita, Daisuke, Cady, Nancy, Kirchhoff, Patricia, Rivera-Eschright, Nadia, Adducci, Joseph, Morales Gomez, Brianna, Goncharova, Alina, Hox, Sophia H., Petrovitch, Helen, Matwichyna, Michael, Jenkins, Victoria, Bermudez, Nina O., Ishii, Renée R., Hsia, Daniel S., Cefalu, William T., Greenway, Frank L., Waguespack, Celeste, King, Erin, Haynes, Natalie, Thomassie, Amy, Bourgeois, Brandi, Hazlett, Claire, Henry, Robert, Mudaliar, Sunder, Boeder, Schafer, Pettus, Jeremy, Diaz, Elsa, DeLue, Catherine, Castro, Erick, Hernandez, Sylvia, Krakoff, Jonathan, Curtis, Jeffrey M., Killean, Tina, Joshevama, Erica, Diaz, Enrique, Martin, Denelle, Karshner, Tracey, Albu, Jeanine, Pi-Sunyer, F. Xavier, Frances, Sylvaine, Maggio, Carol, Ellis, Emily, Bastawrose, Joseph, Gong, Xiuqun, Banerji, Mary Ann, August, Phyllis, Lorber, Daniel, Brown, Necole M., Josephson, Debra H., Thomas, Lorraine L., Tsovian, Mari, Cherian, Ajini, Jacobson, Marlo H., Mishko, Motria M., Kirkman, M. Sue, Bergamo, Katherine, Buse, John B., Dostou, Jean, Young, Laura, Goley, April, Kerr, Jeffrey, Largay, Joseph F., Guarda, Sonia, Cuffee, Juanita, Culmer, Dawn, Fraser, Rachael, Almeida, Hope, Coffer, Samantha, Debnam, Elizabeth, Kiker, Lauren, Morton, Sarah, Josey, Kim, Fuller, Gail, Garvey, W. Timothy, Cherrington, Andrea, Golson, Dana, Griffith, Olivia, Robertson, Mary Catherine, Agne, April, McCullars, Steve, Craig, Jacqueline, Kersey, Kimberly, Rogge, M. Colleen, Wilson, Carla, Burton, Kathryn, Lipp, Sonia, Vonder Meulen, Mary Beth, Schroeder, Emily, Steiner, Stephanie, Baker, Chelsea, Underkofler, Chantal, Douglass, Sara, Sivitz, William, Cline, Erin, Knosp, Laura, McConnell, Jennifer, Lowe, Tamara, Herman, William H., Pop-Busui, Rodica, Tan, Meng H., Martin, Catherine, Waltje, Andrea, Goodhall, Lynn, Eggleston, Rebecca, Kuo, Shihchen, Bule, Stephanie, Kessler, Nancy, LaSalle, Elizabeth, Seaquist, Elizabeth R., Bantle, Anne, Kumar, Anjali, Redmon, Bruce, Bantle, John, Harindhanavudhi, Tasma, Coe, Mary, Mech, Michael, Taddese, Abdisa, Lesne, Lesia, Smith, Shannon, Kuechenmeister, Lisa, Shivaswamy, Vijay, Morales, Ana Laura, Rodriguez, Maria Grace, Seipel, Kris, Alfred, Alissa, Eggert, Jenna, Lord, Grace, Taylor, William, Tillson, Renee, Schade, David S., Adolphe, Allen, Burge, Mark, Duran-Valdez, Elizabeth, Martinez, Janae, Hernandez McGinnis, Doris, Pucchetti, Benjamin, Scripsick, Elizabeth, DeFronzo, Ralph A., Cersosimo, Eugenio, Abdul-Ghani, Muhammad, Triplitt, Curtis, Verastiqui, Hector, Garza, Rosa Irene, Wright, Kathryn, Puckett, Curtiss, Raskin, Philip, Rhee, Chanhaeng, Abraham, Soma, Jordan, Lin Fan, Sao, Serey, Morton, Luisa, Smith, Oralenda, Osornio Walker, Laura, Schnurr-Breen, Laura, Ayala, Rosa, Kraymer, Robert, Sturgess, Daytheon, Utzschneider, Kristina M., Alarcon-Casas Wright, Lorena, Boyko, Edward, Tsai, Elaine C., Trence, Dace L., Fattaleh, Basma N., Montgomery, Brenda K., Atkinson, Karen M., Concepcion, Tessa, Kozedub, Alexandra, Moak, Cameron, Rhothisen, Samantha, Elasy, Tom A., Martin, Stephanie, Shackelford, Laura, Goidel, Rita, Hinkle, Nina, Lipps Hogan, Janie, Lovell, Cynthia, Myers, Janet, McGill, Janet B., Salam, Maamoun, Kissel, Sarah, Schweiger, Toni, Recklein, Carol, Tamborlane, William, Gatcomb, Patricia, Camp, Anne, Gulanski, Barbara, Inzucchi, Silvio, Pham, Kim, Alguard, Michele, Lessard, Katarzyna, Perez, Magalys, Magenheimer, Elizabeth, Montoza, Abmaridel, Nathan, David M., Lachin, John, Krause-Steinrauf, Heidi, Burch, Henry, Linder, Barbara, Bremer, Andrew, Backman, Michael, Bebu, Ionut, Buys, C.J., Fagan Murphy, Anna, Gao, Yuping, Gramzinski, Michaela, Hall, Stephanie, Legowski, Elizabeth, Arey, Alyssa, Bethepu, Joel, Lund, Claire, Mangat Dhaliwal, Pam, McGee, Paula, Mesimer, Emily, Ngo, Lisa, Steffes, Michael, Seegmiller, Jesse, Saenger, Amy, Arends, Valerie, Gabrielson, Deanna, Conner, Todd, Stuart, Warren, Day, Jolene, Scrymgeour, Alexandra, Soliman, Elsayed Z., Zhang, Zhu-Ming, Campbell, Charles, Hu, Julie, Keasler, Lisa, Hensley, Susan, Li, Yabing, Herman, William, Mihalcea, Rada, Perez-Rosas, Veronica, Prosser, Lisa, Resnicow, Kenneth, Ye, Wen, Shao, Hui, Zhang, Ping, Luchsinger, Jose, Sanchez, Danurys, Burch, Henry B., Fradkin, Judith, Groessl, Erik, Chong, Helen, Hillery, Naomi, Abdouch, Ivan, Brantley, Paula, Broyles, Frances E., Canaris, Gay, Copeland, Paul, Craine, Jeri J., Fein, Warren L., Lee, Melissa S., Meiners, Rebecca, Meiners, Vaughn, O’Neal, Hollis, Park, James E., Sledge, Edward, Steppel-Resnick, Jeanne, Turchin, Alexander, Higgins, John, Fischer, Lawrence, Golden, Sherita, Gonzalez, Jeffrey, Naik, Aanand, Walker, Elizabeth, Doner Lotenberg, Lynne, Gallivan, Joanne M., Lim, Joanne, Tuncer, Diane M., and Behringer-Massera, Stephanie

Subjects
endocrine system diseases, Diabetes Mellitus, Type 2, Endocrinology, Diabetes and Metabolism, Smoke, T-Lymphocytes, Internal Medicine, Humans, Pathophysiology, Fires
Abstract

Islet autoimmunity may contribute to β-cell dysfunction in type 2 diabetes (T2D). Its prevalence and clinical significance have not been rigorously determined. In this ancillary study to the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE), we investigated the prevalence of cellular and humoral islet autoimmunity in patients with T2D duration of 4.0 ± 3.0 years (HbA1c 7.5 ± 0.5% on metformin alone). We measured T-cell autoreactivity against islet proteins, islet autoantibodies against 65-kDa GAD antigen, IA-2, and zinc transporter-8, and β-cell function. Cellular islet autoimmunity was present in 41.3%, humoral islet autoimmunity in 13.5%, and both in 5.3%. β-Cell function calculated as incremental area under the curve of glucose from 0–120 min (iAUC-CG) and ΔC-peptide(0–30)/Δglucose(0–30) from an oral glucose tolerance test was lower among T-cell–positive (T+) than T-cell–negative (T−) individuals using two different adjustments for insulin sensitivity (iAUC-CG: 13.2% [95% CI 0.3, 24.4] or 11.4% [95% CI 0.4, 21.2] lower; ΔC-peptide[0–30]/Δglucose[0–30]: 19% [95% CI 3.1, 32.3] or 17.7% [95% CI 2.6, 30.5%] lower). T+ patients had 17% higher HbA1c (95% CI 0.07, 0.28) and 7.7 mg/dL higher fasting plasma glucose levels (95% CI 0.2, 15.3) than T− patients. We conclude that islet autoimmunity is much more prevalent in patients with T2D than previously reported. T-cell–mediated autoimmunity is associated with diminished β-cell function and worse glycemic control.

Published
2021

41. Levels of Serum Phosphorylated Neurofilament Heavy Subunit in Clinically Healthy Standardbred Horses

Author

Irene Rojas-Núñez, Adriana Morales Gomez, Emily K Selland, Theresa Oduol, Stephanie Wolf, Scott Palmer, and Hussni O. Mohammed

Subjects
Cross-Sectional Studies, Equine, Neurofilament Proteins, Intermediate Filaments, Animals, Horse Diseases, Horses, Nervous System Diseases, Biomarkers
Abstract

Neurofilaments heavy chain proteins (pNF-H) have been identified as useful serum biomarkers for humans and animals with neurologic conditions, some of which can lead to poor performance, and athletic injuries. However, there are no published reports that describe a reference range for serum pNF-H levels in healthy racehorses. This cross-sectional study was carried out to determine the serum concentration of pNF-H in 1,349 samples collected from 1,291 clinically healthy standardbred (SB) racehorses. Data on age, time of sampling (pre-race or post-race), and finishing position during a race were collected. The concentration of pNF-H in serum samples was determined using an enzyme-linked immunosorbent assay (ELISA). The appropriate statistical techniques were used to determine the median serum concentration of pNF-H in these horses, if the serum concentration of pNF-H changed with age, if there were changes in the serum concentration of pNF-H during a race, and if there was an association between serum concentration of pNF-H, and the finishing position for the horse. The median serum concentration of pNF-H in this group of clinically healthy SB horses was 0.0 ng/mL. The concentration of pNF-H in serum was not associated with the age of the horses in this study as was determined by regression analysis. There was no significant change in the serum concentration of pNF-H before and after a race in paired samples. There was no association of serum concentration of pNF-H and the finishing position of the horses after the race. The data from this study supports use of0.412 ng/mL as a reference interval for measurement of serum levels of pNF-H in SB racehorses as 95% of the collected samples fell into the range 0.0-0.412 ng/mL.

Published
2021

42. Education, Policy, and Social Change: Experiences from Latin America.

Author

Morales-Gomez, Daniel A., Torres, Carlos Alberto, Morales-Gomez, Daniel A., and Torres, Carlos Alberto

Abstract

Using both a retrospective and a prospective view, this book examines the links joining research, policy, and change in education in Latin America. It inquires about the relationships among the economy, politics, and the state. It reviews the praxis of education in Latin American countries and in the context of the development trends of the 1980s. The various chapters discuss the challenges these societies have faced in education in their progression toward the 21st century. Following the introduction by Daniel A. Morales-Gomez and Carlos Alberto Torres, part 1 analyzes the dialectic among educational changes, policies, and research in societies where democratic systems are confronted by socioeconomic and political problems that may deeply affect their development in the 1990s. Chapters include the following: (1) "Bolivia: Society, State, and Education in Crisis" (Jorge Rivera P.); (2) "Columbia: Educational Research and Policy--Problems of the 1980s, Issues for the 1990s" (Benjamin Alvarez); (3) "Ecuador: Basic Quechuan Education" (Consuelo Yanez Cossio); (4) "Peru: Education for National Identity--Ethnicity and Andean Nationalism" (Gonzalo Portocarrero M.); and (6) "Venezuela: Education after Prosperity" (Carmen Garcia Guadilla and Ramon Casanova). Part 2 examines educational research and policies in countries facing different stages in the transition from authoritarian to democratic rule. Chapters include the following: (7) "Argentina: Education in Transition--From Dictatorship to Democracy" (Emilio Fermin Mignone); (8) "Brazil: Conflicts between Public and Private Schooling and the Brazilian Constitutions" (Moacir Gadotti); and (9) "Chile: The State and Higher Education" (Jose Joaquin Brunner). Part 3 addresses the links among educational research, policy, and change during the 1980s in nations that have been affected by political turmoil, widespread poverty, and hemispherical geopolitical interests. Chapters include the following: (10) "Costa Rica: Education and Politics--A Historical Perspective" (Astrid Fischel Volio); (11) "Cuba: Educational Research and Decision Making" (Lidia Turner Marti and Elvira Martin Sabina); and (12) "Nicaragua: Education and Social Transformation, 1979-91" (Robert F. Arnove and Anthony Dewees). The conclusion, "Educational Research and Policy in the 1990s--Future Challenges," is by Daniel A. Morales-Gomez and Carlos Alberto Torres. Five tables, a bibliography of 384 references, and an index are included. (LMI)

Published
1992

43. Bioaccessibility of Macrominerals and Trace Elements from Tomato (Solanum lycopersicum L.) Farmers’ Varieties

Author

Lillian Barros, María de Cortes Sánchez-Mata, José Pinela, Virginia Fernández-Ruiz, María Ciudad-Mulero, Isabel Ferreira, Patricia Morales Gomez, and Ana Maria Carvalho

Subjects
Local varieties, Minerals, Micronutrients, Health (social science), In vitro gastrointestinal digestion, Bioaccessibility, Plant Science, Solanum lycopersicum L, local varieties, minerals, micronutrients, in vitro gastrointestinal digestion, bioaccessibility, dietary reference intakes, Dietary reference intakes, Health Professions (miscellaneous), Microbiology, Food Science
Abstract

Traditional farmers’ varieties of tomato grown under extensive farming techniques are considered delicious and healthy foods and are preferred by local consumers. Tomatoes are an important component of a healthy diet, as they provide essential micronutrients, including minerals, which are vital to healthy development, disease prevention, and wellbeing. Given the considerable dietary intake of tomatoes and the scarcity of information about the bioaccessibility of inorganic constituents in this fruit, this study was carried out to evaluate the content and bioaccessibility of minerals (macro- and microelements) in tomato farmers’ varieties widely cultivated in northeastern Portugal homegardens. Among the macroelements, K stood out as the most abundant mineral in the studied varieties, followed by Mg, Ca, and Na. Regarding the microelements, while the yellow tomato had higher concentrations of Fe and Cu, the round tomato had more Zn and Mn. The in vitro bioaccessibility assessment showed that, among the macroelements, Mg was more bioaccessible than Ca and K when all the tomato varieties were considered together. Among the microelements, Cu seemed to be the most bioaccessible. Although the contribution of a 100 g serving of the studied tomato farmers’ varieties to the dietary reference intakes (DRIs) of minerals is relatively low, this food could contribute to reaching these mineral requirements, as it is included in the diet of most of the population, especially in Mediterranean regions. The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for the financial support through national funds FCT/MCTES granted to CIMO (UIDB/00690/2020), the ALIMNOVA Research Group (ref: 951505), and FEI21/34 (UCM). The FCT funded the contracts of J. Pinela (CEECIND/01011/2018) and L. Barros (institutional scientific employment program contract). info:eu-repo/semantics/publishedVersion

Published
2022
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44. Prevalence of antibiotic resistant pathogenic E. coli from animals, retail and humans diagnosed with Gastroenteritisv

Author

Patrick L. McDonough, Hussni O. Mohammed, Adriana M. Morales Gomez, Elizabeth Aguilera Nunez, and Yung-Fu Chang

Subjects
Antibiotic resistance, Biology, Microbiology
Abstract

Foodborne pathogens represent one of the major challenges to health systems around the world. This risk is exacerbated by the presence of antimicrobial resistant (AMR) pathogens. Knowledge of the presence of these pathogens in the food supply chain would help in establishing intervention strategies to mitigate their risk. The objective of this study was to detect AMR among serotypes of Escherichia coli (E. coli) food adulterants serotypes of E. coli in the food supply chain and among isolates from gastroenteritis cases. E. coli isolates recovered from animals, meat processing plants, retail, and humans were examined for the presence of AMR using phenotypic and genotypic approaches. AMR to aminoglycosides, β-lactams, and tetracycline were detected in all isolates recovered from these sources at different levels. Similarly, presence of the bla-Tem, bla-SHV, aadA, and strAB genes were detected in isolates from these sources but there was no significant correlation between the genetic detection and phenotypic expression AMR.

Published
2021
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45. Attrition of Thoroughbred and Standardbred racehorses at New York Racetracks due to exercise and non-exercise related fatalities during the 2016 - 2019 racing seasons

Author

Scott Palmer, Adriana M. Morales Gomez, and Hussni O. Mohammed

Subjects
Male, Equine, business.industry, Incidence (epidemiology), Significant difference, New York, Horse, Retrospective cohort study, medicine.disease, Sudden death, Breed, United States, Physical Conditioning, Animal, Medicine, Animals, Attrition, Horse Diseases, Horses, Seasons, business, Intact male, Demography, Retrospective Studies
Abstract

A longitudinal retrospective study was carried out to investigate the attrition of Thoroughbred (TB) and Standardbred (SB) horses racing at New York racetracks during the 2016 to 2019 seasons. The data were collected from the New York State Gaming Commission (NYSGC) Equine Breakdown, Death, Injury and Incident (EBDII), The Jockey Club InCompass Solutions, and The United States Trotting Association Pathway databases. Survival analysis was used to compare the predisposing factors by breed of the horse. The study included 431 horses (360 TB and 71 SB). There was a significant difference between the average incidence of attrition events per start for TB (0.304) and SB (0.035) horses. There was a significant difference in the median age to attrition between TB (4.2 years) and SB (7.5 years) horses. There was also a significant difference between the average number of starts to attrition for TB (13.6) and SB (125.5) horses. Among the causes of attrition events in the two breeds musculoskeletal injuries and medical conditions were significantly higher among TB horses, while sudden death was significantly higher among SB horses. The multivariate analysis showed that the hazard of attrition was affected by the age of the horse, age at first start, whether the horse was intact male, type of activity (racing training or other) and the breed of the horse. SB horses were less likely to experience attrition events in comparison to TB horses.

Published
2021

46. The use of an integrative approach to improve accuracy of species identification and detection of new species in studies of stream fish diversity

Author

Jose Alejandro Morales Gomez, Luiz Henrique Garcia Pereira, Jerson Rogelio Chanchay Castro, Claudio Oliveira, Pilar Mireya Huatatoca Vargas, Universidade Federal da Integração Latino-Americana – UNILA, and Universidade Estadual Paulista (Unesp)

Subjects
0106 biological sciences, 0301 basic medicine, Species complex, Paraná River basin, Biodiversity, Identification key, Plant Science, Conservation, Fish distribution, Characiformes, 010603 evolutionary biology, 01 natural sciences, DNA barcoding, Sensitivity and Specificity, 03 medical and health sciences, Rivers, Deforestation, Genetics, Animals, DNA Barcoding, Taxonomic, Phylogeny, Polymorphism, Genetic, biology, Ecology, Fishes, General Medicine, biology.organism_classification, Checklist, Characidae, 030104 developmental biology, Insect Science, Animal Science and Zoology, Identification (biology), Brazil
Abstract

Made available in DSpace on 2021-06-25T10:29:01Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) In this study, we made an inventory of the stream and headwater ichthyofauna of the left bank of the Itaipu Dam Reservoir, located in the lower part of the Upper Paraná River basin, using an integrative approach of molecular and morphological data. The area is located in the western portion of the Paraná state in Brazil, in an area of about 8,000 km2 highly impacted by deforestation and intensive agriculture. For taxonomic identification of species, we used an identification key combined with the DNA barcoding approach. We found 48 species belonging to six orders, 13 families, and 37 genera. The Siluriformes and Characiformes were the most representative orders (75%) and the Characidae was the most representative family (20.8%). Nine species prevailed in this region, making up to 86% of all specimens collected. The integrative approach proved to be useful by allowing the unambiguous identification of all species, including those cases in which morphological characters were not conclusive for species identification, cases of cryptic species, and species with high morphological plasticity. In addition, the integrative approach highlighted six to 13 new putative species depending on the approach considered. Our study provides a relevant contribution to the knowledge of fish diversity in a poorly studied area of the Paraná River basin. We showed that the use of an integrative approach in inventory studies improves species identification and the discovery of new, cryptic, and overlooked species, being a powerful and necessary tool to quantify biodiversity. Laboratório de Biodiversidade e Ecologia Molecular Instituto Latino-Americano de Ciências da Vida e da Natureza – ILACVN Universidade Federal da Integração Latino-Americana – UNILA, Av. Tarquínio Joslin dos Santos, 1000 Departamento de Biologia estrutural e Funcional Instituto de Biociências Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP Departamento de Biologia estrutural e Funcional Instituto de Biociências Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP FAPESP: 2014/26508-3 FAPESP: 2016/09204-6 FAPESP: 2018/20610-1 CNPq: 306054/2006-0

Published
2021

47. Rapid Adaptation and Remote Delivery of Undergraduate Research Training during the COVID-19 Pandemic

Author

Yang Yowler, Joanna, primary, Knier, Kit, additional, WareJoncas, Zachary, additional, Ehlers, Shawna L., additional, Ekker, Stephen C., additional, Guasp Reyes, Fabiola, additional, Horazdovsky, Bruce F., additional, Mueller, Glenda, additional, Morales Gomez, Adriana, additional, Sood, Amit, additional, Sussman, Caroline R., additional, Scholl, Linda M., additional, Weavers, Karen M., additional, and Pierret, Chris, additional

Published
2021
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48. Risk of bacterial foodborne pathogen infection among gastroenteritis cases in Qatar

Author

Manik Sharma, Adriana Morales-Gomez, Sanjay Doiphode, Emad E. Ibrahim, Ali A. Sultan, Nilda N. Valenzuela, Hussni O. Mohammed, and Kenlyn Peters

Subjects
Salmonella, Foodborne pathogen, Campylobacter, medicine, Biology, medicine.disease_cause, Microbiology
Abstract

Foodborne illness has been determined to be one of the major limitations to the advancement of world health. Bacterial pathogens among the leading causes of foodborne illness are Escherichia coli (E. coli), Campylobacter, Salmonella, and Listeria. The risk of these pathogens was investigated among gastroenteritis cases in the diverse population of the state of Qatar. Fecal samples from patients admitted to Hamad Medical Corporation (HMC) with complaints of gastroenteritis were screened for the targeted pathogens using a combination of bacterial enrichments and molecular detection. Salmonella was the most common pathogen (42.9%), followed by E. coli (35.3%), and Campylobacter (21.0%). C. jejuni was the most common species of Campylobacter (67.4%). The probability of detection of E. coli decreased with age. Meanwhile, both probabilities of detection of Campylobacter and Salmonella increased with age. Listeria monocytogenes was much less common among gastroenteritis cases compared to the other pathogens.

Published
2020
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49. Detection of cytolethal distending toxin and other virulent factors in Escherichia coli samples from animal livestock, retail foods and gastroenteritis human cases in Qatar

Author

Ali A. Sultan, Kenlyn Peters, Sanjay Doiphode, Nilda N. Valenzuela, Adriana M. Morales Gomez, Hussni O. Mohammed, Emad E. Ibrahim, and Ahmed Salem

Subjects
Cytolethal distending toxin, business.industry, medicine, Virulence, Livestock, Biology, business, medicine.disease_cause, Escherichia coli, Microbiology
Abstract

Cytolethal distending toxin (CDT) is a heterotrimeric AB-type genotoxin produced by several clinically important bacterial pathogens. To better understand the risk of CDT within the food supply and human gastroenteritis patients in Qatar, we investigated the frequency of the CDT gene (cdtB) among Escherichia coli (E. coli) strains recovered from food products, animal livestock, and human gastroenteritis patients. In this cross-sectional study, E. coli isolates were screened for cdtB using polymerase chain reaction (PCR). cdtB positive strains were further examined for E. coli cdtB gene types (cdt I, cdt II, cdt III, cdt IV and cdtV), serotypes O157: H7, and non-O157 Shiga toxin-producing E. coli O26, O45, O103, O111, O121, and O145. Screening for other virulent factors, stx (Shiga toxin gene) and eae (gene that encodes intimin) genes were also performed. The cdtB gene was detected in E. coli isolates sourced from all three groups; animal livestock (17%), retail foods (8%), and human gastroenteritis patients (3%). Although the incidence of cdtB gene harboring E. coli is relatively low among gastroenteritis patients, there is still a risk of infection from animal reservoirs as well as retail food products. Among the three groups, E. coli isolates from humans had the lowest occurrence of cdtB, stx, eae, and O157: H7. Furthermore, we advise implementing monitoring at the food production and preparation level.

Published
2020
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50. Diurnal variation of NMDA receptor expression in the rat cerebral cortex is associated with traumatic brain injury damage

Author

Elvia Coballase-Urrutia, Luz Navarro, Francisco Estrada-Rojo, Marina Martinez-Vargas, and Julio Morales-Gomez

Subjects
Male, 0301 basic medicine, medicine.medical_specialty, Time Factors, Traumatic brain injury, Receptor expression, Excitotoxicity, lcsh:Medicine, medicine.disease_cause, Receptors, N-Methyl-D-Aspartate, Neuroprotection, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Cortex (anatomy), Brain Injuries, Traumatic, medicine, Animals, Rats, Wistar, lcsh:Science (General), lcsh:QH301-705.5, business.industry, Circadian rhythm, lcsh:R, Motor Cortex, Glutamate receptor, General Medicine, medicine.disease, Rats, Research Note, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, lcsh:Biology (General), Cerebral cortex, business, 030217 neurology & neurosurgery, Motor cortex, lcsh:Q1-390
Abstract

Objective Data from our laboratory suggest that recovery from a traumatic brain injury depends on the time of day at which it occurred. In this study, we examined whether traumatic brain injury -induced damage is related to circadian variation in N‐methyl‐d‐aspartate receptor expression in rat cortex. Results We confirmed that traumatic brain injury recovery depended on the time of day at which the damage occurred. We also found that motor cortex N‐methyl‐d‐aspartate receptor subunit NR1 expression exhibited diurnal variation in both control and traumatic brain injury-subjected rats. However, this rhythm is more pronounced in traumatic brain injury—subjected rats, with minimum expression in those injured during nighttime hours. These findings suggest that traumatic brain injury occurrence times should be considered in future clinical studies and when designing neuroprotective strategies for patients.

Published
2018
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