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BACKGROUND: Klippel-Trenaunay syndrome is an embryonic developmental defect of mesodermal tissues that affects angiogenesis at various stages, characterized by the triad of capillary malformation, venous malformation, and limb overgrowth with or without lymphatic malformation. It appears very infrequently in adulthood. An incidence of 2-5 per 100,000 inhabitants has been described, with a predominance in males. Mosaic activating mutations in the PIK3CA gene are suggested in studies in embryonic development involving angiogenesis. CLINICAL CASE: A 23-year-old female patient who began her condition from birth with a "red spot" that covered thigh to the left leg sole. Two years ago, she began with a progressive increase in volume, accompanied by hyperthermia and hyperesthesia that have made her unable to walk, as well as the appearance of varicose veins at the ankle level. Doppler ultrasound evidenced perforating veins with data of incompetence at the level of 10 cm from the knee and 38 cm from the ankle and left saphenous-femoral reflux. CONCLUSIONS: Klippel-Trenaunay syndrome is a rare complex congenital entity whose incidence and prevalence are unknown, which may go unnoticed by the physician. We must consider future complications such as coagulation disorders, thromboembolism, bleeding, venous insufficiency, cellulitis, and pain. A multidisciplinary approach is needed to treatment, ideally in a multidisciplinary vascular anomaly center. [ABSTRACT FROM AUTHOR]

BACKGROUND: DRESS syndrome (drug reaction with eosinophilia and systemic symptoms) is associated with exposure to certain drugs. It is potentially fatal (20%), with significant dermatological manifestations and visceral involvement. The main treatment is the immediate withdrawal of the suspected drug, as well as the use of systemic corticosteroids. CLINICAL CASE: A 61-year-old female patient, who, after two weeks of ampicillin consumption, presented a generalized morbilliform skin rash, non-involving soles and palms, and also itchy and painful symmetrical erythematous plaques with lamellar scaling on the face and edema of lips and oral mucosa. Laboratory tests showed leukocytosis with eosinophilia and lymphocytosis as well as impaired kidney and liver function. The histopathological study described hyperkeratosis, spongiosis, and inflammatory infiltrates in the superficial dermis. CONCLUSIONS: DRESS syndrome is a rare and potentially fatal drug reaction, which should be suspected in the presence of a morbilliform rash, fever, hypereosinophilia, as well as visceral involvement, to establish a timely diagnosis and treatment to avoid complications such as multi-organ failure, as well as mortality. [ABSTRACT FROM AUTHOR]