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This study investigated the anti-caries and anti-inflammatory effects of mouthwash formulations containing Punica granatum (pomegranate) peel extract (PPE), sodium-trimetaphosphate, and low concentrations of fluoride. PPE was characterized using high-performance liquid chromatography (ellagic acid and punicalagin). Total phenolics were quantified among formulations, and their stability was analyzed for 28 days. The formulation effects were evaluated as follows: (1) inorganic component concentration and reduced demineralization on bovine enamel blocks subjected to pH cycling; (2) anti-biofilm effect on dual-biofilms of Streptococcus mutans ATCC 25175 and Candida albicans ATCC 10231 treated for 1 and 10 min, respectively; and (3) cytotoxicity and production of inflammatory mediators (interleukin-6 and tumor necrosis factor-alpha). The formulation containing 3% PPE, 0.3% sodium-trimetaphosphate, and 225 ppm of fluoride resulted in a 34.5% surface hardness loss; a 13% (treated for 1 min) and 36% (treated for 10 min) biofilm reduction in S. mutans; a 26% (1 min) and 36% (10 min) biofilm reduction in C. albicans; absence of cytotoxicity; and anti-inflammatory activity confirmed by decreased interleukin-6 production in mouse macrophages. Thus, our results provide a promising prospect for the development of an alcohol-free commercial dental product with the health benefits of P. granatum that have been recognized for a millennium.

ABSTRACT Objective: To understand the socio-emotional competencies mobilized by nurse leaders during and after facing the Covid-19 pandemic in a university hospital. Method: Case study, conducted with sixteen nurses working in the leadership of units and services at a university hospital in northeastern Brazil. Data collected in two moments through semi-structured interviews. The interviews took place between August to December 2022 and January to August 2023. An inductive and coded thematic analysis was performed, according to the bucket theme technique, assisted by the NVivo12 software and supported by the grouping of twenty-five items included in the Socio-emotional competence scale. Results: During the fight against the Covid-19 pandemic, nurses expressed a mix of emotions due to their lack of knowledge about the disease. Faced with the climate of fear and the feeling of helplessness, they developed strategies that minimized the risks of illness and death. Two categories emerged: Emotional climate experienced by nurses and Coping strategies developed by nurses in the context of the Covid-19 pandemic. Final considerations: The competencies of social awareness, regulation, self-control, creativity, and emotional awareness were identified in the nurses’ reports. These skills contributed to coping with the pandemic period, through the participation, involvement, and integration of professionals.

O estudo objetivou averiguar os requisitos para construção de aplicativo para alta segura e transição de cuidados do recém-nascido. Trata-se de estudo exploratório, realizado com 12 profissionais de enfermagem que atuam no cuidado ao recém-nascido no Nordeste brasileiro. A coleta de dados ocorreu por meio de formulário entre maio a setembro de 2023. Foi adotado referencial teórico da Transição de Cuidados de Meleis. Emergiram três unidades de sentido: Conceito de alta hospitalar segura e a transição dos cuidados do RN; Prontidão para alta segura do RN e Expectativas sobre construção e utilização de tecnologia cuidativa para a alta segura do recém-nascido. Os requisitos envolveram a necessidade de desvelar os principais critérios e parâmetros envolvidos na alta, bem como a capacidade de conectar profissionais de saúde a familiares/cuidadores do recém-nascido, com capacidade de instruir e elucidar dúvidas destacando a importância da participação da equipe multidisciplinar no desenvolvimento, bem como na divulgação do aplicativo. Logo, os requisitos sobre a tecnologia cuidativa foram identificados e subsidiarão a criação de aplicativo para apoio à alta do paciente recém-nascido visando à obtenção de melhorias na transição de cuidados e segurança na alta dessa população.

The microbiota performs multiple functions vital to host fitness, including defense against pathogens and adaptation to dietary changes. Yet, how environmental challenges shape microbiota resilience to nutrient fluctuation remains largely unexplored. Here, we show that transient gut infection can optimize host metabolism toward the usage of carbohydrates. Following acute infection and clearance of the pathogen, mice gained more weight as a result of white adipose tissue expansion. Concomitantly, previously infected mice exhibited enhanced carbohydrate (glucose) disposal and insulin sensitivity. This metabolic remodeling depended on alterations to the gut microbiota, with infection-elicited Betaproteobacteria being sufficient to enhance host carbohydrate metabolism. Further, infection-induced metabolic alteration protected mice against stunting in the context of limited nutrient availability. Together, these results propose that alterations to the microbiota imposed by acute infection may enhance host fitness and survival in the face of nutrient restriction, a phenomenon that may be adaptive in settings where both infection burden and food precarity are prevalent.

Abstract Objective: to describe the feelings expressed by health professionals when caring for child and adolescent victims of sexual violence from the theoretical perspective of Symbolic Interactionism. Method: qualitative research carried out with 30 female health professionals. An instrument was used consisting of closed questions for sociodemographic data and a script with open questions for interviews. The data was organized and analyzed using Nvivo software version 12, according to Bardin’s proposal, from the perspective of Symbolic Interactionism in the work of Charles Morris. The project was approved by the Research Ethics Committee. Results: five thematic categories emerged, revealing feelings of empathy, fear, indignation, suffering, and consternation. These feelings remained in the interviewees’ memories, making caring for child and adolescent victims of sexual violence a moving and difficult experience that deeply marks the life of the health professional. Conclusion: there is a need to adopt strategies to support the mental health of professionals who work in services that provide general care to children and adolescents, considering that there is a possibility that they will provide care to child and adolescent victims of sexual violence in compliance with pre-existing public policies.

Objetivo: discutir o papel da atuação da equipe de enfermagem mediante a pandemia da COVID-19, reconhecendo sua importância na promoção e educação em saúde, prevenção de doenças e ordenação da atenção à saúde durante a crise. Metodologia: Trata-se de um estudo exploratório-descritivo, com abordagem qualitativa, conduzida na Estratégia Saúde da Família (ESF) de Parelhas-RN. A coleta de dados ocorreu no mês de janeiro de 2022, utilizando entrevistas semiestruturadas com a equipe de enfermagem, e a seleção dos participantes foi feita focando nestes profissionais. Resultados: A amostra do estudo é composta por um perfil totalmente feminino (100%) e traz uma análise concreta dos dados apresentados, onde avaliamos o impacto das notícias falsas na pandemia e todo um contexto de trabalho de toda uma equipe de enfermagem. Conclusão: A pandemia de COVID-19 impactou significativamente o trabalho da equipe de enfermagem da Estratégia Saúde da Família (ESF) de Parelhas-RN, alterando sua rotina de atendimento, que implicaram em novas adaptações frente às novas demandas exigidas pela pandemia.

Background Desserts with vegetable ingredients are a constantly expanding global market due to the search for alternatives to cow’s milk. Fermentation of these matrices by lactic acid bacteria can add greater functionality to the product, improving its nutritional, sensory, and food safety characteristics, as well as creating bioactive components with beneficial effects on health. Concern for health and well-being has aroused interest in byproducts of the industry that have functional properties for the body, such as mature coconut water, a normally discarded residue that is rich in nutrients. This study aimed to develop a probiotic gelatin based on pulp and water from mature coconuts and evaluate the physicochemical characteristics, viability of the Lacticaseibacillus rhamnosus LR32 strain in the medium, as well as the texture properties of the product. Methods After collection and cleaning, the physicochemical characterization, mineral analysis, analysis of the total phenolic content and antioxidant activity of mature coconut water were carried out, as well as the centesimal composition of its pulp. Afterwards, the gelling was developed with the addition of modified corn starch, gelatin, sucrose, and probiotic culture, being subjected to acidity analysis, texture profile and cell count, on the first day and every 7 days during 21 days of storage, under refrigeration at 5 °C. An analysis of the centesimal composition was also carried out. Results The main minerals in coconut water were potassium (1,932.57 mg L−1), sodium (19.57 mg L−1), magnesium (85.13 mg L−1) calcium (279.93 mg L−1) and phosphorus (11.17 mg L−1), while the pulp had potassium (35.96 g kg−1), sodium (0.97 g kg−1), magnesium (2.18 g kg−1), 37 calcium (1.64 g kg−1), and phosphorus (3.32 g kg−1). The phenolic content of the water and pulp was 5.72 and 9.77 mg gallic acid equivalent (GAE) 100 g−1, respectively, and the antioxidant capacity was 1.67 and 0.98 39 g of 2, 2-diphenyl-1-picrylhydrazyl (DPPH) mg−1, respectively. The coconut pulp had 2.81 g 100 g−1of protein, 1.11 g 100 g−1 of 40 ash, 53% moisture, and 5.81 g 100 g−1 of carbohydrates. The gelatin produced during the storage period presented firmness parameters ranging from 145.82 to 206.81 grams-force (gf), adhesiveness from 692.85 to 1,028.63 gf sec, cohesiveness from 0.604 to 0.473, elasticity from 0.901 to 0.881, gumminess from 86.27 to 97.87 gf, and chewiness from 77.72 to 91.98 gf. Regarding the viability of the probiotic microorganism, the dessert had 7.49 log CFU g−1 that remained viable during the 21-day storage, reaching 8.51 CFU g−1. Acidity ranged from 0.15 to 0.64 g of lactic acid 100 g−1. The centesimal composition of the product showed 4.88 g 100 g−1 of protein, 0.54 g 100 g−1 of ash, 85.21% moisture, and 5.37g 100 g−1 of carbohydrates. The development of the gelatin made it possible to obtain a differentiated product, contributing to diversification in the food sector, providing a viable alternative for maintaining consumer health and reducing costs compared to desserts already available on the market.

Este artigo, como apresentamos em sua versão de apresentação oral, tem por objetivo analisar a interação entre o conceito de ponto de escuta, os ruídos e os sons ambientes. Para tanto, teremos como centro o longa-metragem Memória (Apichatpong Weerasethakul, 2021). Nos interessa demonstrar a relação possível entre a personagem principal e nós, como espectadores, pela partilha de um incerto ponto de escuta que transita entre sonoridades subjetivas e objetivas. Temos como hipótese que tal incerteza sobre o ponto de escuta, por parte da personagem e estendida aos espectadores, relativiza dicotomias da teoria do cinema sobre a localização espacial ou subjetiva dos sons. Nossa análise tem a intenção de abrir possiblidades de diferentes resultados quanto à recepção e identificação sonoras.

This study proposes an affordable plasma device that utilizes a parallel-plate dielectric barrier discharge geometry with a metallic mesh electrode, featuring a straightforward 3D-printed design. Powered by a high-voltage supply adapted from a cosmetic plasma device, it operates on atmospheric air, eliminating the need for gas flux. Surface modification of polyethylene treated with this device was characterized and showed that the elemental composition after 15 min of plasma treatment decreased the amount of C to ~80 at% due to the insertion of O (~15 at%). Tested against Candida albicans and Staphylococcus aureus, the device achieved a reduction of over 99% in microbial load with exposure times ranging from 1 to 10 min. Simultaneously, the Vero cell viability remained consistently high, namely between 91% and 96% across exposure times. These results highlight this device’s potential for the surface modification of materials and various infection-related applications, boasting affordability and facilitating effective antimicrobial interventions.

In Portugal, Decree-Law no. 231/81 of July 28 defines the association in a participation contract as the association of a person with an economic activity carried out by a third party, with the former participating in the profits and/or losses for the latter. A joint-stock association is not a civil or commercial society because it is not attributed to any legal personality. Conversely, there is no shared economic activity. The member exercises the activity without any intrusion from the member and shares the profits and (eventually) losses with the member. It's a legal business. For the law, it is the associate that arises in legal relations with third parties as the owner of the business and its rights and obligations. The partnership agreement does not constitute a new legal entity or even an autonomous asset. It is a contract for the distribution of results without property autonomy or legal personality. In addition to the management functions, it is also up to the associate to settle and deliver the VAT due to the state.

Introdução: Muito se tem discutido a respeito dos cuidados paliativos em enfermos terminais internados em uma UTI. A equipe multiprofissional possibilita a dignidade da pessoa humana, promovendo a diminuição da dor, e o entendimento quanto ao tratamento de paliação esclarecendo sempre que tal medida não é um tratamento terminal dos pacientes, tanto para o enfermo como para os entes que o cercam. Objetivo: buscou se o papel do enfermeiro na UTI com pacientes em cuidados paliativos. Metodologia: Foi realizada uma pesquisa bibliográfica com uma análise qualitativa, sendo utilizados, para tanto, o Google acadêmico, SCIELO – Scientific Electronic Library Online, revistas especializadas, dentre outros sites que tratam sobre o devido tema. Conclusão: A equipe multiprofissional exerce um papel fundamental no processo dos cuidados paliativos, sendo ela responsável por analisar as necessidades básicas que cada doente necessita. Cabe ao enfermeiro a responsabilidade de aplicar tais decisões visto que sua figura está diretamente ligada ao paciente. É de suma relevância proporcionar maior qualidade de vida ao paciente, garantindo no processo mais conforto, menos dor, mais acolhimento e humanização.

Intrusive dislocation is the most frequent type of traumatic injury in the primary dentition, characterized by displacement of the tooth into the alveolus. Intrusions require a thorough physical examination, radiographs of diagnostic value, and follow-up of the case, since the prognosis is unfavorable, mainly due to the probability of damage to the permanent tooth germ. This work aims to report a clinical case of intrusive dislocation in the primary dentition, from diagnosis to follow-up. This is a male patient, 3 years old, who attended the Emergency of the Children’s Specialty Clinic – State University of Londrina (UEL) due to dento-alveolar trauma in the antero-superior region that occurred three days ago. On clinical examination, tooth 61 had grade II intrusion (one-third of the crown visible), and tooth 62 had grade I intrusion, with more than one-third of the crown visible. Radiographically, a buccal inclination was observed, with no fracture of the bone plate. Thus, we opted for conservative treatment, waiting for the spontaneous re-eruption of the teeth involved. Furthermore, parents were informed about the possible consequences of this type of trauma and the need for clinical and radiographic follow-up consultations. After eight months of follow-up, the teeth erupted satisfactorily. It is extremely important to establish a protocol for observation and control of the traumatized tooth, observing signs and symptoms of the tissues involved in the trauma to reduce sequelae in both dentitions.

Immune checkpoint pathways, i.e., coinhibitory pathways expressed as feedback following immune activation, are crucial for controlling an excessive immune response. Cytotoxic T lymphocyte antigen-4 (CTLA-4) and programmed cell death protein-1 (PD-1) are the central classical checkpoint inhibitory (CPI) molecules used for the control of neoplasms and some infectious diseases, including some fungal infections. As the immunosuppression of severe paracoccidioidomycosis (PCM), a chronic granulomatous fungal disease, was shown to be associated with the expression of coinhibitory molecules, we hypothesized that the inhibition of CTLA-4 and PD-1 could have a beneficial effect on pulmonary PCM. To this end, C57BL/6 mice were infected with Paracoccidioides brasiliensis yeasts and treated with monoclonal antibodies (mAbs) α-CTLA-4, α-PD-1, control IgG, or PBS. We verified that blockade of CTLA-4 and PD-1 reduced the fungal load in the lungs and fungal dissemination to the liver and spleen and decreased the size of pulmonary lesions, resulting in increased survival of mice. Compared with PBS-treated infected mice, significantly increased levels of many pro- and anti-inflammatory cytokines were observed in the lungs of α-CTLA-4-treated mice, but a drastic reduction in the liver was observed following PD-1 blockade. In the lungs of α-CPI and IgG-treated mice, there were no changes in the frequency of inflammatory leukocytes, but a significant reduction in the total number of these cells was observed. Compared with PBS-treated controls, α-CPI- and IgG-treated mice exhibited reduced pulmonary infiltration of several myeloid cell subpopulations and decreased expression of costimulatory molecules. In addition, a decreased number of CD4+ and CD8+ T cells but sustained numbers of Th1, Th2, and Th17 T cells were detected. An expressive reduction in several Treg subpopulations and their maturation and suppressive molecules, in addition to reduced numbers of Treg, TCD4+, and TCD8+ cells expressing costimulatory and coinhibitory molecules of immunity, were also detected. The novel cellular and humoral profiles established in the lungs of α-CTLA-4 and α-PD-1-treated mice but not in control IgG-treated mice were more efficient at controlling fungal growth and dissemination without causing increased tissue pathology due to excessive inflammation. This is the first study demonstrating the efficacy of CPI blockade in the treatment of pulmonary PCM, and further studies combining the use of immunotherapy with antifungal drugs are encouraged.

Because of continual generation of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is critical to design the next generation of vaccines to combat the threat posed by SARS-CoV-2 variants. We developed human adenovirus (HAd) vector-based vaccines (HAd-Spike/C5 and HAd-Spike) that express the whole Spike (S) protein of SARS-CoV-2 with or without autophagy-inducing peptide C5 (AIP-C5), respectively. Mice or golden Syrian hamsters immunized intranasally (i.n.) with HAd-Spike/C5 induced similar levels of S-specific humoral immune responses and significantly higher levels of S-specific cell-mediated immune (CMI) responses compared with HAd-Spike vaccinated groups. These results indicated that inclusion of AIP-C5 induced enhanced S-specific CMI responses and similar levels of virus-neutralizing titers against SARS-CoV-2 variants. To investigate the protection efficacy, golden Syrian hamsters immunized i.n. either with HAd-Spike/C5 or HAd-Spike were challenged with SARS-CoV-2. The lungs and nasal turbinates were collected 3, 5, 7, and 14 days post challenge. Significant reductions in morbidity, virus titers, and lung histopathological scores were observed in immunized groups compared with the mock- or empty vector-inoculated groups. Overall, slightly better protection was seen in the HAd-Spike/C5 group compared with the HAd-Spike group.

IntroductionPlant-based meats (PBM) are an emerging set of food technologies that could reduce the environmental impacts of food systems by mitigating consumer demand for animal products. However, scaling up the production and consumption of plant-based meats requires overcoming multiple technological, regulatory, political, and market barriers. An evidence-based prioritization of needs and actions may help actors (e.g., investors, funders, policymakers) who wish to help scale PBM achieve desired outcomes with limited resources.Research questionWhat actions could most effectively help to scale up the production and/or consumption of plant-based meat in Brazil?MethodsWe selected Brazil as a case study of a country with a significant animal agriculture sector and a burgeoning PBM sector. We constructed a panel of nine experts and employed the Delphi technique during two rounds of an online survey to iteratively assess the degree of consensus and disagreement around the relative priority of 14 possible actions (identified from relevant literature) that could help to scale up the production and/or consumption of PBM in Brazil. We used the Importance, Neglect, and Tractability framework.ResultsThe panelists collectively concluded that the top priority action for scaling up both the production and the consumption of plant-based meat in Brazil was to reduce the price of products for consumers. For most priority actions, there was greater consensus among panelists in the second round of the survey.DiscussionOur findings contribute to an improved understanding of (a) which actions may be of highest priority for investors, funders, and policymakers, (b) synergies and differences between priority actions to scale up the production versus consumption of PBM in Brazil, (c) the relative merits of focusing on scaling up PBM production versus consumption, and (d) the strengths and limitations of assessing expert opinion on alternative protein futures using the Delphi technique.

Esta pesquisa é fruto da análise da literatura publicada sobre a trajetória de lideranças femininas em terreiros de Candomblé. Interessou identificar o que dizem os trabalhos de doutorado e mestrado acadêmico sobre as histórias de vida dessas mulheres e, com isso, pensar as possibilidades de suas narrativas a partir da Lei 10.639/03. Utilizando uma abordagem de revisão sistemática da literatura, a pesquisa se baseou no Catálogo de Teses e Dissertações da Capes e identificou 15 pesquisas que versam sobre a trajetória das sacerdotisas ou que as utilize como mote para o estudo de questões relacionadas aos terreiros que lideraram/lideram. A análise, empreendida em diálogo com o referencial teórico da História das Mulheres, desvelou as complexas redes de sociabilidade e ancestralidade que rodeiam as ialorixás e a centralidade delas na cultura religiosa afro-brasileira, bem como demonstrou as potencialidades de suas trajetórias para o ensino de História e Cultura Afro-brasileira nas escolas.

This work aimed to improve the oxygen transfer mass coefficient (kLa) in mixing reactors, first evaluating the effect of agitation and aeration and then evaluating the influence of the size and concentration of silica microparticles. Silicon dioxide synthesized via the sol-gel technique, commercial sand, and beach sand were characterized by particle size distribution, scanning electron microscopy, XRD, EDS, FTIR, TG/DTA, and BET. The particles presented average values of approximately 9.2, 76.9, 165.1, and 364.4 µm, with irregular surfaces and different roughness. Silica sol-gel is amorphous while beach and commercial sand have a crystalline structure consisting of silicon, oxygen, and carbon residues. Silica sol-gel presents a higher loss of mass and surface area than other silica microparticles, with a shallow mass loss and a smaller surface. Increasing aeration and agitation improves the kLa, as well as adding silica microparticles. The best kLa was found using silica microparticles with approximately 75 µm concentrations of 1.0 g L−1 (silica sol-gel) and 2.0 g L−1 (commercial and treated beach sand). All silica microparticles used in this work improve mass transfer performance in mixing bioreactors.

This study focuses on the cytotoxic evaluation of functionalized multi-walled carbon nanotubes (MWCNT) and microbial biofilm formation on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanocomposites incorporating MWCNTs functionalized with gamma-aminobutyric acid (GABA) and carboxyl groups. The materials were characterized for cytotoxicity to fibroblasts and antimicrobial effects against Escherichia coli, Staphylococcus aureus and Candida albicans. The functionalization of MWCNTs was performed through oxidation (CNT-Ox) and GABA attachment (CNT-GB). The PHBV/CNT nanocomposites were produced via melt mixing. All MWCNT suspensions showed non-toxic behaviors after 24 h of incubation (viability higher than 70%); however, prolonged incubation and higher concentrations led to increased cytotoxicity. The antibacterial potential of PHBV/CNT nanocomposites against S. aureus showed a reduction in biofilm formation of 64% for PHBV/CNT-GB and 20% for PHBV/CNT-Ox, compared to neat PHBV. Against C. albicans, no reduction was observed. The results indicate promising applications for PHBV/CNT nanocomposites in managing bacterial infections, with GABA-functionalized CNTs showing enhanced performance.

ABSTRACT Objectives: to analyze the development of children discharged from the Neonatal Intensive Care Unit and how hospitalization interferes with child development, from parents’ point of view. Methods: a descriptive-exploratory, documentary and qualitative study, carried out with parents of children discharged from the Intensive Care Unit through a telephone survey and supplementation in medical records. Data were analyzed using Bardin’s tool and discussed according to scientific evidence. Results: from parents’ point of view, delay in physical development was not observed, however difficulties in breastfeeding and weight gain were reported. Changes in speech and changes in behavior considered abnormal were also delays in child evolution. Final Considerations: from parents’ point of view, changes in speech may be associated with hospitalization in an Intensive Care Unit, while difficulties related to breastfeeding and delays in cognition may be altered by conditions of prematurity and low weight at birth.

Este artigo é fruto da análise da trajetória formativa de Maria das Dores da Silva (1900-1939), fundadora e primeira ialorixá do Terreiro de Santa Bárbara – Nação Xambá, terreiro de Candomblé localizado em Pernambuco. A pesquisa teve como objetivo analisar como o estudo sobre a formação dessa ialorixá contribui para o campo da História da Educação. Valendo-se metodologicamente da pesquisa bibliográfica, da pesquisa documental, da metodologia da História Oral e teoricamente da noção de educação não formal a partir de Gohn (2006) a pesquisa desvelou os processos formativos que compuseram a liderança religiosa de Maria Oyá, como ficou conhecida Maria das Dores da Silva, assim como revelou problemas de ser mulher, negra e praticante de religião de matriz afro-brasileira no período do Estado Novo (1937-1945) governado pelo então presidente Getúlio Vargas (1882-1954) que impediu as práticas religiosas que veneravam os orixás

Background The demand for lactic acid bacteria products, especially probiotics, has increased. Bacteria that increase polyphenol bioavailability and act as bio preservatives are sought after. This study aims to identify autochthonous lactic acid cultures from EMBRAPA that demonstrate β-glucosidase activity and inhibitory effect on microbial sanitary indicators. Methods Cell-free extracts were obtained by sonicating every 5 s for 40 min. The extracts were mixed with cellobiose and incubated at 50 °C. The reaction was stopped by immersing the tubes in boiling water. The GOD-POD reagent was added for spectrophotometer readings. Antimicrobial activity was tested against reference strains using the agar well diffusion method. Lactic cultures in MRS broth were added to 0.9 cm wells and incubated. The diameter of the inhibition zones was measured to determine the extension of inhibition. Results Only L. rhamnosus EM1107 displayed extracellular β-glucosidase activity, while all autochthonous strains except L. plantarum CNPC020 demonstrated intracellular activity for this enzyme. L. plantarum CNPC003 had the highest values. On the other hand, L. plantarum CNPC020, similarly to L. mucosae CNPC007, exhibited notable inhibition against sanitary indicators. These two strains significantly differed from the other five autochthonous cultures regarding S. enterica serovar Typhimurium ATCC 14028 inhibition (P < 0.05). However, they did not differ from at least one positive control in terms of inhibition against S. aureus ATCC 25923 and E. coli ATCC 25922 (P > 0.05). Therefore, it is advisable to consider these cultures separately for different technological purposes, such as phenolics metabolism or bio preservative activity. This will facilitate appropriate selection based on each specific property required for the intended product development.

La soumission chimique par GHB dans les milieux festifs nocturnes : qu’est-ce que c’est ?

ABSTRACT Purpose: to investigate, examine and synthesize evidence from studies on permanent education for health professionals aimed at the covid-19 pandemic. Methods: six national and international indexed sources will be searched. The review will include studies with any methodological approach, addressing permanent education for health professionals during the covid-19 pandemic. The context of health services in any scenario will be considered - national or international primary, specialized, or hospital healthcare. Final Considerations: research results are expected to reveal the topics approached in permanent health education in various national and international contexts. The review will also list the gains and problems found in various places while applying permanent education as a strategy to fight the covid-19 pandemic.