Olivares, Alberto Ignacio Olivares, Leitao, Gabriel Azevedo Alves, Pimenta, Yan Cardoso, Cantelli, Carina Pacheco, Fumian, Tulio Machado, Fialho, Alexandre Madi, da Silva e Mouta Junior, Sergio, Delgado, Isabella Fernandes, Nordgren, Johan, Svensson, Lennart, Miagostovich, Marize Pereira, Leite, Jose Paulo Gagliardi, Moraes, Marcia Terezinha Baroni de, Olivares, Alberto Ignacio Olivares, Leitao, Gabriel Azevedo Alves, Pimenta, Yan Cardoso, Cantelli, Carina Pacheco, Fumian, Tulio Machado, Fialho, Alexandre Madi, da Silva e Mouta Junior, Sergio, Delgado, Isabella Fernandes, Nordgren, Johan, Svensson, Lennart, Miagostovich, Marize Pereira, Leite, Jose Paulo Gagliardi, and Moraes, Marcia Terezinha Baroni de
Objectives: To verify the frequency of viruses causing acute gastroenteritis (AGE) in association with the histo-blood group antigen (HBGA) and Rotarix (TM) vaccination coverage in children from the Amazon region. Design: Fecal and saliva samples were collected from children with AGE (n = 485) and acute respiratory infection (ARI) (n = 249) clinical symptoms. Rotavirus A (RVA), norovirus, human adenovirus (HAdV), and sapovirus (SaV) were verified in feces by molecular detection. Saliva samples were used for HBGA phenotyping/FUT3 genotyping. Blood group types, clinical aspects and Rotarix (TM) RVA vaccination data were recorded. Results: Norovirus remained the most prevalently detected cause of AGE (38%, 184/485 and ARI 21.3%, 53/249). High HAdV frequencies were observed in AGE children (28.6%, 139/485) and ARI children (37.3%, 93/249). RVA was the third most prevalent virus causing AGE (22.7%, 110/485 and ARI 19.3%, 48/249) and a low RV1 coverage (61%, 448/734) was verified. The SaV frequencies were lower (7.2%, 35/485 for AGE and 6.8%, 17/249 for ARI). Secretor children were HBGA susceptible to HAdV infection (OR 1.5, 95% CI 1.0-2.3; P = 0.04) but not to RVA, norovirus or SaV infection. Conclusions: Norovirus could be considered the main etiological agent of AGE. No association was verified for HBGA susceptibility to RVA, norovirus and SaV. Secretor children showed a slight susceptibility to HAdV infection and the Le (a-b-) heterogeneous SNPs on the FUT3 gene. (C) 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases., Funding Agencies|Coordination for the Improvement of Higher Education Personnel (CAPES) "Programa de Professor Visitante no ExteriorCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [88881.337140/201901, 01/2019]; Foun-dation for Research Support of the State of Rio de Janeiro-FAPERJ "Edital Carlos Chagas Filho"; National Council for Scientific and Technological Development-CNPqConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [424376/20164]; Oswaldo Cruz Institute-IOC (PAEF)