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24 results on '"Mora-López, Francisco"'

3. VEXAS‐Syndrom erfolgreich mit Canakinumab therapiert

Author

Collantes‐Rodríguez, Cristina, primary, Jiménez‐Gallo, David, additional, de la Varga‐Martínez, Raquel, additional, Mora‐López, Francisco, additional, Garrastazul‐Sánchez, Maria Paz, additional, and Linares‐Barrios, Mario, additional

Published
2023
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4. Vexas syndrome successfully treated with canakinumab

Author

Collantes‐Rodríguez, Cristina, primary, Jiménez‐Gallo, David, additional, de la Varga‐ Martínez, Raquel, additional, Mora‐López, Francisco, additional, Garrastazul‐Sánchez, Maria Paz, additional, and Linares‐Barrios, Mario, additional

Published
2023
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7. Potential Diagnostic Value of the Differential Expression of Histone H3 Variants between Low- and High-Grade Gliomas

Author

Hervás-Corpión, Irati, primary, Gallardo-Orihuela, Andrea, additional, Catalina-Fernández, Inmaculada, additional, Iglesias-Lozano, Irene, additional, Soto-Torres, Olga, additional, Geribaldi-Doldán, Noelia, additional, Domínguez-García, Samuel, additional, Luna-García, Nuria, additional, Romero-García, Raquel, additional, Mora-López, Francisco, additional, Iriarte-Gahete, Marianela, additional, Morales, Jorge C., additional, Campos-Caro, Antonio, additional, Castro, Carmen, additional, Gil-Salú, José L., additional, and Valor, Luis M., additional

Published
2021
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15. Response to flecainide test in Andersen‐Tawil syndrome with incessant ventricular tachycardia.

Author

Fernández, Marcos, Marín, María Del Rosario, Fernández‐Armenta, Juan, Mora‐López, Francisco, Fernández Rivero, Rafael, Berruezo, Antonio, Cano Calabria, Lucas, and Vázquez García, Rafael

Subjects
ADRENERGIC beta blockers, AMIODARONE, ARRHYTHMIA treatment, ATRIAL fibrillation treatment, ACETAZOLAMIDE, FLECAINIDE, BISOPROLOL, ECHOCARDIOGRAPHY, ELECTROCARDIOGRAPHY, SYNCOPE, GENETIC testing, VENTRICULAR tachycardia, ANDERSEN syndrome, DIAGNOSIS, THERAPEUTICS
Abstract

The article presents a case study of a 25-year-old woman who has an episode of syncope while swimming. Topics discussed include results of electrocardiographic monitoring that revealed high premature ventricular complex (PVC) burden; use of a drug called, flecainide for the treatment of Andersen-Tawil syndrome with incessant ventricular tachycardia; and conductance of genetic testing on the patient's parents.

Published
2018
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19. Syntaxin‐4 is implicated in the secretion of antibodies by human plasma cells

Author

Gómez‐Jaramillo, Laura, Delgado‐Pérez, Luis, Reales, Elena, Mora‐López, Francisco, Mateos, Rosa M., García‐Poley, Antonio, Brieva, José A., and Campos‐Caro, Antonio

Abstract

The functional role of SNAP23, STX3, and STX4 in Ab secretion; SNAP23, STX4 is implicated in the Ab secretion by a myeloma cell line and by normal human colon lamina propria PCs. PCs are responsible for the production and secretion of antibodies, the effector molecules of the humoral immune response. The molecular mechanisms responsible for vesicle docking and secretion implicated in the antibody‐secretion process are not well‐known, as they have not been studied, but it is known that SNARE proteins are responsible for many membrane‐fusion processes in the cell. We show here that freshly isolated human colon LP‐PCs and T‐PCs from MM‐PC patients and the U266 cell line, as a model for PC secretion, contain a set of these proteins. SNAP23, STX3, and STX4 were localized mainly in the plasma membrane of PCs, and interactions of SNAP23 with STX3 and with STX4 were proven by IP. Interaction between SNAP23 and STX4 was also confirmed in situ. With the use of siRNA, as well as shRNA, the functional role of SNAP23, STX3, and STX4 in antibody secretion was also examined. The findings demonstrate that in addition to SNAP23, STX4 is implicated in the antibody secretion by a myeloma cell line and by normal human colon LP‐PCs.

Published
2014
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20. Vexas syndrome successfully treated with canakinumab.

Author

Collantes-Rodríguez C, Jiménez-Gallo D, de la Varga-Martínez R, Mora-López F, Garrastazul-Sánchez MP, and Linares-Barrios M

Subjects
Skin Diseases, Genetic, Mutation, Humans, Myelodysplastic Syndromes, Antibodies, Monoclonal therapeutic use, Antibodies, Monoclonal, Humanized therapeutic use
Published
2023
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24. The expression of PRDI-BF1 beta isoform in multiple myeloma plasma cells.

Author

Ocaña E, González-García I, Gutiérrez NC, Mora-López F, Brieva JA, and Campos-Caro A

Subjects
Gene Expression Regulation, Neoplastic genetics, Humans, Multiple Myeloma genetics, Positive Regulatory Domain I-Binding Factor 1, Protein Isoforms biosynthesis, Protein Isoforms genetics, Repressor Proteins genetics, Transcription Factors genetics, Gene Expression Regulation, Neoplastic physiology, Multiple Myeloma metabolism, Plasma Cells metabolism, Repressor Proteins biosynthesis, Transcription Factors biosynthesis
Abstract

The PRDM1 gene, a master regulator of plasma cells (PC), can generate two transcription factor isoforms: PRDI-BF1alpha and PRDI-BF1beta. The present study shows that purified human normal PC have a significantly lower levels of PRDI-BF1beta expression than that in tumoral PC isolated from multiple myeloma (MM) (0.06+/-0.01 and 0.25+/-0.05, respectively; p<0.001). The role of this finding in MM is discussed.

Published
2006

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