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1. Adverse events in cognitive behavioral therapy and relaxation training for children and adolescents with obsessive-compulsive disorder: A mixed methods study and analysis plan for the TECTO trial

Author

Pretzmann, Linea, Christensen, Sofie Heidenheim, Bryde Christensen, Anne, Funch Uhre, Camilla, Uhre, Valdemar, Thoustrup, Christine Lykke, Clemmesen, Iben Thiemer, Gudmandsen, Tin Aaen, Korsbjerg, Nicoline Løcke Jepsen, Mora-Jensen, Anna-Rosa Cecilie, Ritter, Melanie, Olsen, Markus Harboe, Clemmensen, Line Katrine Harder, Lindschou, Jane, Gluud, Christian, Thomsen, Per Hove, Vangkilde, Signe, Hagstrøm, Julie, Rozental, Alexander, Jeppesen, Pia, Verhulst, Frank, Hybel, Katja Anna, Lønfeldt, Nicole Nadine, Plessen, Kerstin Jessica, Poulsen, Stig, and Pagsberg, Anne Katrine

Published
2023
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2. Family-based cognitive behavioural therapy versus family-based relaxation therapy for obsessive-compulsive disorder in children and adolescents (the TECTO trial): a statistical analysis plan for the randomised clinical trial

Author

Olsen, Markus Harboe, Hagstrøm, Julie, Lønfeldt, Nicole Nadine, Uhre, Camilla, Uhre, Valdemar, Pretzmann, Linea, Christensen, Sofie Heidenheim, Thoustrup, Christine, Korsbjerg, Nicoline Løcke Jepsen, Mora-Jensen, Anna-Rosa Cecilie, Ritter, Melanie, Engstrøm, Janus, Lindschou, Jane, Siebner, Hartwig Roman, Verhulst, Frank, Jeppesen, Pia, Jepsen, Jens Richardt Møllegaard, Vangkilde, Signe, Thomsen, Per Hove, Hybel, Katja, Clemmesen, Line Katrine Harder, Gluud, Christian, Plessen, Kerstin Jessica, Pagsberg, Anne Katrine, and Jakobsen, Janus Christian

Published
2022
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3. Correction: Family-based cognitive behavioural therapy versus family-based relaxation therapy for obsessive-compulsive disorder in children and adolescents: protocol for a randomised clinical trial (the TECTO trial)

Author

Pagsberg, Anne Katrine, Uhre, Camilla, Uhre, Valdemar, Pretzmann, Linea, Christensen, Sofie Heidenheim, Thoustrup, Christine, Clemmesen, Iben, Gudmandsen, Amanda Aaen, Korsbjerg, Nicoline Løcke Jepsen, Mora-Jensen, Anna-Rosa Cecilie, Ritter, Melanie, Thorsen, Emilie D., Halberg, Klara Sofie Vangstrup, Bugge, Birgitte, Staal, Nina, Ingstrup, Helga Kristensen, Moltke, Birgitte Borgbjerg, Kloster, Anne Murphy, Zoega, Pernille Juul, Mikkelsen, Marie Sommer, Harboe, Gitte Sommer, Larsen, Katrin Frimann, Clemmensen, Line Katrine Harder, Lindschou, Jane, Jakobsen, Janus Christian, Engstrøm, Janus, Gluud, Christian, Siebner, Hartwig Roman, Thomsen, Per Hove, Hybel, Katja, Verhulst, Frank, Jeppesen, Pia, Jepsen, Jens Richardt Møllegaard, Vangkilde, Signe, Olsen, Markus Harboe, Hagstrøm, Julie, Lønfeldt, Nicole Nadine, and Plessen, Kerstin Jessica

Published
2022
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4. Family-based cognitive behavioural therapy versus family-based relaxation therapy for obsessive-compulsive disorder in children and adolescents: protocol for a randomised clinical trial (the TECTO trial)

Author

Pagsberg, Anne Katrine, Uhre, Camilla, Uhre, Valdemar, Pretzmann, Linea, Christensen, Sofie Heidenheim, Thoustrup, Christine, Clemmesen, Iben, Gudmandsen, Amanda Aaen, Korsbjerg, Nicoline Løcke Jepsen, Mora-Jensen, Anna-Rosa Cecilie, Ritter, Melanie, Thorsen, Emilie D., Halberg, Klara Sofie Vangstrup, Bugge, Birgitte, Staal, Nina, Ingstrup, Helga Kristensen, Moltke, Birgitte Borgbjerg, Kloster, Anne Murphy, Zoega, Pernille Juul, Mikkelsen, Marie Sommer, Harboe, Gitte Sommer, Larsen, Katrin Frimann, Clemmesen, Line Katrine Harder, Lindschou, Jane, Jakobsen, Janus Christian, Engstrøm, Janus, Gluud, Christian, Siebner, Hartwig Roman, Thomsen, Per Hove, Hybel, Katja, Verhulst, Frank, Jeppesen, Pia, Jepsen, Jens Richardt Møllegaard, Vangkilde, Signe, Olsen, Markus Harboe, Hagstrøm, Julie, Lønfeldt, Nicole Nadine, and Plessen, Kerstin Jessica

Published
2022
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9. Adverse Events in Cognitive Behavioral Therapy and Relaxation Training for Children and Adolescents with Obsessive-Compulsive Disorder: A Mixed Methods Study and Analysis Plan for the TECTO Trial

Author

Pretzmann, Linea, primary, Christensen, Sofie Heidenheim, additional, Christensen, Anne Bryde, additional, Uhre, Camilla, additional, Uhre, Valdemar, additional, Thoustrup, Christine Lykke, additional, Clemmesen, Iben Thiemer, additional, Gudmandsen, Tin Aaen, additional, Korsbjerg, Nicoline Løcke Jepsen, additional, Mora-Jensen, Anna-Rosa Cecilie, additional, Ritter, Melanie, additional, Olsen, Markus Harboe, additional, Clemmensen, Line Katrine Harder, additional, Lindschou, Jane, additional, Gluud, Christian, additional, Thomsen, Per Hove, additional, Vangkilde, Signe, additional, Hagstrøm, Julie, additional, Rozental, Alexander, additional, Jeppesen, Pia, additional, Verhulst, Frank, additional, Hybel, Katja Anna, additional, Lønfeldt, Nicole Nadine, additional, Plessen, Kerstin J., additional, Poulsen, Stig, additional, and Pagsberg, Anne Katrine, additional

Published
2023
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10. Adverse events in cognitive behavioral therapy and relaxation training for children and adolescents with obsessive-compulsive disorder:A mixed methods study and analysis plan for the TECTO trial

Author

Pretzmann, Linea, Christensen, Sofie Heidenheim, Christensen, Anne Bryde, Funch Uhre, Camilla, Uhre, Valdemar, Thoustrup, Christine Lykke, Clemmesen, Iben Thiemer, Gudmandsen, Tin Aaen, Korsbjerg, Nicoline Løcke Jepsen, Mora-Jensen, Anna Rosa Cecilie, Ritter, Melanie, Olsen, Markus Harboe, Clemmensen, Line Katrine Harder, Lindschou, Jane, Gluud, Christian, Thomsen, Per Hove, Vangkilde, Signe, Hagstrøm, Julie, Rozental, Alexander, Jeppesen, Pia, Verhulst, Frank, Hybel, Katja Anna, Lønfeldt, Nicole Nadine, Plessen, Kerstin Jessica, Poulsen, Stig, and Pagsberg, Anne Katrine

Subjects
Adolescent, Adverse effects, Obsessive-compulsive disorder, Randomized clinical trial, Child, Cognitive behavioral therapy
Abstract

Background: Knowledge on adverse events in psychotherapy for youth with OCD is sparse. No official guidelines exist for defining or monitoring adverse events in psychotherapy. Recent recommendations call for more qualitative and quantitative assessment of adverse events in psychotherapy trials. This mixed methods study aims to expand knowledge on adverse events in psychotherapy for youth with OCD. Methods: This is an analysis plan for a convergent mixed methods study within a randomized clinical trial (the TECTO trial). We include at least 128 youth aged 8–17 years with obsessive-compulsive disorder (OCD). Participants are randomized to either family-based cognitive behavioral therapy (FCBT) or family-based psychoeducation and relaxation training (FPRT). Adverse events are monitored quantitatively with the Negative Effects Questionnaire. Furthermore, we assess psychiatric symptoms, global functioning, quality of life, and family factors to investigate predictors for adverse events. We conduct semi-structured qualitative interviews with all youths and their parents on their experience of adverse events in FCBT or FPRT. For the mixed methods analysis, we will merge 1) a qualitative content analysis with descriptive statistics comparing the types, frequencies, and severity of adverse events; 2) a qualitative content analysis of the perceived causes for adverse events with prediction models for adverse events; and 3) a thematic analysis of the participants’ treatment evaluation with a correlational analysis of adverse events and OCD severity. Discussion: The in-depth mixed methods analysis can inform 1) safer and more effective psychotherapy for OCD; 2) instruments and guidelines for monitoring adverse events; and 3) patient information on potential adverse events. The main limitation is risk of missing data. Trial registration: ClinicalTrials.gov identifier: NCT03595098. Registered on July 23, 2018.

Published
2023

11. Associations Between the Severity of Obsessive-Compulsive Disorder and Vocal Features in Children and Adolescents: Protocol for a Statistical and Machine Learning Analysis

Author

Clemmensen, Line Katrine Harder, primary, Lønfeldt, Nicole Nadine, additional, Das, Sneha, additional, Lund, Nicklas Leander, additional, Uhre, Valdemar Funch, additional, Mora-Jensen, Anna-Rosa Cecilie, additional, Pretzmann, Linea, additional, Uhre, Camilla Funch, additional, Ritter, Melanie, additional, Korsbjerg, Nicoline Løcke Jepsen, additional, Hagstrøm, Julie, additional, Thoustrup, Christine Lykke, additional, Clemmesen, Iben Thiemer, additional, Plessen, Kersten Jessica, additional, and Pagsberg, Anne Katrine, additional

Published
2022
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12. Correction:Family-based cognitive behavioural therapy versus family-based relaxation therapy for obsessive-compulsive disorder in children and adolescents: protocol for a randomised clinical trial (the TECTO trial) (BMC Psychiatry, (2022), 22, 1, (204), 10.1186/s12888-021-03669-2)

Author

Pagsberg, Anne Katrine, Uhre, Camilla, Uhre, Valdemar, Pretzmann, Linea, Christensen, Sofie Heidenheim, Thoustrup, Christine, Clemmesen, Iben, Gudmandsen, Amanda Aaen, Korsbjerg, Nicoline Løcke Jepsen, Mora-Jensen, Anna Rosa Cecilie, Ritter, Melanie, Thorsen, Emilie D., Halberg, Klara Sofie Vangstrup, Bugge, Birgitte, Staal, Nina, Ingstrup, Helga Kristensen, Moltke, Birgitte Borgbjerg, Kloster, Anne Murphy, Zoega, Pernille Juul, Mikkelsen, Marie Sommer, Harboe, Gitte Sommer, Larsen, Katrin Frimann, Clemmensen, Line Katrine Harder, Lindschou, Jane, Jakobsen, Janus Christian, Engstrøm, Janus, Gluud, Christian, Siebner, Hartwig Roman, Thomsen, Per Hove, Hybel, Katja, Verhulst, Frank, Jeppesen, Pia, Jepsen, Jens Richardt Møllegaard, Vangkilde, Signe, Olsen, Markus Harboe, Hagstrøm, Julie, Lønfeldt, Nicole Nadine, and Plessen, Kerstin Jessica

Abstract

Following publication of the original article [1], the authors identified an error in the author name of Line Katrine Harder Clemmensen. The incorrect author name is: Line Katrine Harder Clemmesen. The correct author name is: Line Katrine Harder Clemmensen. The author group has been updated above and the original article [1] has been corrected.

Published
2022

13. Additional file 4 of Family-based cognitive behavioural therapy versus family-based relaxation therapy for obsessive-compulsive disorder in children and adolescents: protocol for a randomised clinical trial (the TECTO trial)

Author

Pagsberg, Anne Katrine, Uhre, Camilla, Uhre, Valdemar, Pretzmann, Linea, Christensen, Sofie Heidenheim, Thoustrup, Christine, Clemmesen, Iben, Gudmandsen, Amanda Aaen, Korsbjerg, Nicoline Løcke Jepsen, Mora-Jensen, Anna-Rosa Cecilie, Ritter, Melanie, Thorsen, Emilie D., Halberg, Klara Sofie Vangstrup, Bugge, Birgitte, Staal, Nina, Ingstrup, Helga Kristensen, Moltke, Birgitte Borgbjerg, Kloster, Anne Murphy, Zoega, Pernille Juul, Mikkelsen, Marie Sommer, Harboe, Gitte Sommer, Larsen, Katrin Frimann, Clemmensen, Line Katrine Harder, Lindschou, Jane, Jakobsen, Janus Christian, Engstrøm, Janus, Gluud, Christian, Siebner, Hartwig Roman, Thomsen, Per Hove, Hybel, Katja, Verhulst, Frank, Jeppesen, Pia, Jepsen, Jens Richardt Møllegaard, Vangkilde, Signe, Olsen, Markus Harboe, Hagstrøm, Julie, Lønfeldt, Nicole Nadine, and Plessen, Kerstin Jessica

Subjects
Data_FILES
Abstract

Additional file 4.

Published
2022
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14. Additional file 6 of Family-based cognitive behavioural therapy versus family-based relaxation therapy for obsessive-compulsive disorder in children and adolescents: protocol for a randomised clinical trial (the TECTO trial)

Author

Pagsberg, Anne Katrine, Uhre, Camilla, Uhre, Valdemar, Pretzmann, Linea, Christensen, Sofie Heidenheim, Thoustrup, Christine, Clemmesen, Iben, Gudmandsen, Amanda Aaen, Korsbjerg, Nicoline Løcke Jepsen, Mora-Jensen, Anna-Rosa Cecilie, Ritter, Melanie, Thorsen, Emilie D., Halberg, Klara Sofie Vangstrup, Bugge, Birgitte, Staal, Nina, Ingstrup, Helga Kristensen, Moltke, Birgitte Borgbjerg, Kloster, Anne Murphy, Zoega, Pernille Juul, Mikkelsen, Marie Sommer, Harboe, Gitte Sommer, Larsen, Katrin Frimann, Clemmensen, Line Katrine Harder, Lindschou, Jane, Jakobsen, Janus Christian, Engstrøm, Janus, Gluud, Christian, Siebner, Hartwig Roman, Thomsen, Per Hove, Hybel, Katja, Verhulst, Frank, Jeppesen, Pia, Jepsen, Jens Richardt Møllegaard, Vangkilde, Signe, Olsen, Markus Harboe, Hagstrøm, Julie, Lønfeldt, Nicole Nadine, and Plessen, Kerstin Jessica

Subjects
Data_FILES
Abstract

Additional file 6.

Published
2022
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15. Additional file 2 of Family-based cognitive behavioural therapy versus family-based relaxation therapy for obsessive-compulsive disorder in children and adolescents: protocol for a randomised clinical trial (the TECTO trial)

Author

Pagsberg, Anne Katrine, Uhre, Camilla, Uhre, Valdemar, Pretzmann, Linea, Christensen, Sofie Heidenheim, Thoustrup, Christine, Clemmesen, Iben, Gudmandsen, Amanda Aaen, Korsbjerg, Nicoline Løcke Jepsen, Mora-Jensen, Anna-Rosa Cecilie, Ritter, Melanie, Thorsen, Emilie D., Halberg, Klara Sofie Vangstrup, Bugge, Birgitte, Staal, Nina, Ingstrup, Helga Kristensen, Moltke, Birgitte Borgbjerg, Kloster, Anne Murphy, Zoega, Pernille Juul, Mikkelsen, Marie Sommer, Harboe, Gitte Sommer, Larsen, Katrin Frimann, Clemmensen, Line Katrine Harder, Lindschou, Jane, Jakobsen, Janus Christian, Engstrøm, Janus, Gluud, Christian, Siebner, Hartwig Roman, Thomsen, Per Hove, Hybel, Katja, Verhulst, Frank, Jeppesen, Pia, Jepsen, Jens Richardt Møllegaard, Vangkilde, Signe, Olsen, Markus Harboe, Hagstrøm, Julie, Lønfeldt, Nicole Nadine, and Plessen, Kerstin Jessica

Subjects
Data_FILES
Abstract

Additional file 2.

Published
2022
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16. Additional file 3 of Family-based cognitive behavioural therapy versus family-based relaxation therapy for obsessive-compulsive disorder in children and adolescents: protocol for a randomised clinical trial (the TECTO trial)

Author

Pagsberg, Anne Katrine, Uhre, Camilla, Uhre, Valdemar, Pretzmann, Linea, Christensen, Sofie Heidenheim, Thoustrup, Christine, Clemmesen, Iben, Gudmandsen, Amanda Aaen, Korsbjerg, Nicoline Løcke Jepsen, Mora-Jensen, Anna-Rosa Cecilie, Ritter, Melanie, Thorsen, Emilie D., Halberg, Klara Sofie Vangstrup, Bugge, Birgitte, Staal, Nina, Ingstrup, Helga Kristensen, Moltke, Birgitte Borgbjerg, Kloster, Anne Murphy, Zoega, Pernille Juul, Mikkelsen, Marie Sommer, Harboe, Gitte Sommer, Larsen, Katrin Frimann, Clemmensen, Line Katrine Harder, Lindschou, Jane, Jakobsen, Janus Christian, Engstrøm, Janus, Gluud, Christian, Siebner, Hartwig Roman, Thomsen, Per Hove, Hybel, Katja, Verhulst, Frank, Jeppesen, Pia, Jepsen, Jens Richardt Møllegaard, Vangkilde, Signe, Olsen, Markus Harboe, Hagstrøm, Julie, Lønfeldt, Nicole Nadine, and Plessen, Kerstin Jessica

Subjects
Data_FILES
Abstract

Additional file 3.

Published
2022
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17. Additional file 5 of Family-based cognitive behavioural therapy versus family-based relaxation therapy for obsessive-compulsive disorder in children and adolescents: protocol for a randomised clinical trial (the TECTO trial)

Author

Pagsberg, Anne Katrine, Uhre, Camilla, Uhre, Valdemar, Pretzmann, Linea, Christensen, Sofie Heidenheim, Thoustrup, Christine, Clemmesen, Iben, Gudmandsen, Amanda Aaen, Korsbjerg, Nicoline Løcke Jepsen, Mora-Jensen, Anna-Rosa Cecilie, Ritter, Melanie, Thorsen, Emilie D., Halberg, Klara Sofie Vangstrup, Bugge, Birgitte, Staal, Nina, Ingstrup, Helga Kristensen, Moltke, Birgitte Borgbjerg, Kloster, Anne Murphy, Zoega, Pernille Juul, Mikkelsen, Marie Sommer, Harboe, Gitte Sommer, Larsen, Katrin Frimann, Clemmensen, Line Katrine Harder, Lindschou, Jane, Jakobsen, Janus Christian, Engstrøm, Janus, Gluud, Christian, Siebner, Hartwig Roman, Thomsen, Per Hove, Hybel, Katja, Verhulst, Frank, Jeppesen, Pia, Jepsen, Jens Richardt Møllegaard, Vangkilde, Signe, Olsen, Markus Harboe, Hagstrøm, Julie, Lønfeldt, Nicole Nadine, and Plessen, Kerstin Jessica

Subjects
Data_FILES
Abstract

Additional file 5.

Published
2022
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18. Additional file 1 of Family-based cognitive behavioural therapy versus family-based relaxation therapy for obsessive-compulsive disorder in children and adolescents (the TECTO trial): a statistical analysis plan for the randomised clinical trial

Author

Olsen, Markus Harboe, Hagstrøm, Julie, Lønfeldt, Nicole Nadine, Uhre, Camilla, Uhre, Valdemar, Pretzmann, Linea, Christensen, Sofie Heidenheim, Thoustrup, Christine, Korsbjerg, Nicoline Løcke Jepsen, Mora-Jensen, Anna-Rosa Cecilie, Ritter, Melanie, Engstrøm, Janus, Lindschou, Jane, Siebner, Hartwig Roman, Verhulst, Frank, Jeppesen, Pia, Jepsen, Jens Richardt Møllegaard, Vangkilde, Signe, Thomsen, Per Hove, Hybel, Katja, Clemmesen, Line Katrine Harder, Gluud, Christian, Plessen, Kerstin Jessica, Pagsberg, Anne Katrine, and Jakobsen, Janus Christian

Abstract

Additional file 1: Table 1. Participant characteristics. Figure 1. CONSORT flow diagram. Figure 2. Psychopathology and family burden. Figure 3. Response status at 16 weeks. Figure 4. Negative effects questionnaire. Supplemental Table 1. Detailed comorbidities. Supplemental Table 2. Psychopathology and family burden. Supplemental Table 3. Kidscreen-52. Supplemental Timeline. Supplemental Assumptions.

Published
2022
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19. Determinants of neurodevelopment in early childhood – results from the Copenhagen prospective studies on asthma in childhood ( COPSAC 2010 ) mother–child cohort

Author

Bjarnadóttir, Elín, primary, Stokholm, Jakob, additional, Chawes, Bo, additional, Thorsen, Jonathan, additional, Mora‐Jensen, Anna‐Rosa Cecilie, additional, Deleuran, Maja, additional, Bønnelykke, Klaus, additional, Lauritzen, Lotte, additional, and Bisgaard, Hans, additional

Published
2019
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20. Determinants of neurodevelopment in early childhood - results from the Copenhagen prospective studies on asthma in childhood (COPSAC2010 ) mother-child cohort.

Author

Bjarnadóttir, Elín, Stokholm, Jakob, Chawes, Bo, Thorsen, Jonathan, Mora‐Jensen, Anna‐Rosa Cecilie, Deleuran, Maja, Bønnelykke, Klaus, Lauritzen, Lotte, Bisgaard, Hans, and Mora-Jensen, Anna-Rosa Cecilie

Subjects
BIRTH size, ASTHMATICS, ASTHMA in children, LONGITUDINAL method, CHILDREN
Abstract

Aim: The objective of this study was to identify possible pre- and postnatal factors influencing neurodevelopment of the young child.Methods: We used data from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010 ) mother-child cohort, but excluded those with a neurological diagnosis, born <37 weeks of gestation and birthweights <2500 g, resulting in 650 children analysed. Neurodevelopment was assessed as age of achievement of early milestones, language scores at 1 and 2 years and cognitive score at 2 ½ years of age.Results: Neurodevelopmental scores were not associated with breastfeeding, persistent wheeze, eczema and number of sick days (p > 0.05 in all tests). Early age at milestone achievement was associated with male sex (p = 0.05), lower maternal age (p = 0.02), higher gestational age (p < 0.001) and paternity leave (p = 0.01). A higher 1-year language score was associated with female sex (p = 0.02) and maternal smoking during pregnancy (p = 0.01) and a higher 2-year language score with female sex (p < 0.001) and being first born (p = 0.01). A higher cognitive score was associated with female sex (p = 0.02).Conclusion: Neurodevelopmental scores were unrelated to breastfeeding, persistent wheeze, eczema and number of sick days. Neurodevelopment in early childhood was mostly associated with gender. [ABSTRACT FROM AUTHOR]

Published
2019
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