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3. CKD: The burden of disease invisible to research funders

Author

Roger M, Gallego R, Jimenez V, Perez J, Furlano M, Atxer L, Zurro D, Casabona C, Gomez C, Bermudez P, Armisen M, Lopez S, Porras I, Ruiz J, Orgaz J, Baron M, Ortiz P, de la Fuente G, Gili B, Fresnedo G, Cabrera S, Contreras J, Pelicano M, Blanca A, Portillo M, Alvarez J, Romeo M, Perez M, Diezhandino M, Marrero D, Campo C, Garcia E, Carmona D, Ramirez A, Bellvis L, Haym M, Gomez M, Martinez J, Garrit J, Garrido R, Delgado J, Marimont M, Munoz M, Villares J, Velazquez A, Bonet L, Bravo M, Mateos F, Amador M, Minano J, Belmonte A, Jover A, Rituerto D, Sanchez F, Arenas M, Hernandez R, Serrano B, Ortiz A, Sanz A, Ramos A, Cordoba-David G, Garcia-Jimenez J, Fontecha-Barriuso M, Guerrero-Mauvecin J, Lopez-Diaz A, Sanchez-Nino M, Valino-Rivas L, Cuarental L, Ribagorda M, Pintor-Chocano A, Favero C, Alvarez-Llamas G, Catalina M, Fernandez-Fernandez B, Perez-Gomez M, de Montaner E, Prado R, Rivera J, Verde A, Carriazo S, Luis-Lima S, Sanchez-Rodriguez J, Sanchez S, Ortega M, Parra E, Mateos S, Exposito L, Tejera-Munoz A, Marchant V, Tejedor-Santamaria L, Agilar M, Diekmann F, Genis B, Salinas F, Bajo M, Maneus E, Guillen M, Juarez J, Rodriguez M, Vicente I, Pelicano J, Porras L, Aguiar P, Font M, Andujar A, Cucchiari D, Marrah E, Plana J, Pineiro G, Salgado C, Martin A, Hernandez F, Balboa N, Vicente M, Calvo I, Gonzalez L, Vicente L, Martinez S, Paso A, Garriel M, Lopez J, Palacios A, Saenz D, Garcia P, Bonilla J, Galan A, Marcos E, Perez-Aradros J, San Jose R, Zelaya F, Panades E, Salido J, Balcells R, Criach E, Encarnacion M, Perich L, Girol C, Terroba Y, Oliveras M, Vila L, Cabanas N, Molas C, Torres I, Pelaez S, Serra C, Torres C, Fajardo J, Lahuerta J, Herranz V, Malo A, Castaneda J, Ortiz M, Moreno J, Bermudez A, Olmo R, Pavon F, Peregrin C, Tejero E, Villalba I, Munoz A, De Mier M, Martos C, Baltanas R, Haad C, Bartolome M, Valdemoros R, Serres F, Diaz M, Marino F, Sole L, Saborido M, Majoral J, Martinez M, Calabia E, San Millan J, Lopez-Hoyos M, Benito-Hernandez A, San Segundo D, Valero R, De Ona J, Llavona E, Rodriguez F, Gutierrez R, Pena H, Lopez V, Sola E, Cabello M, Caballero A, Leon M, Ruiz P, Alonso J, Navarro-Gonzalez J, Mora-Fernandez M, Donate-Correa J, Martin-Nunez E, Delgado N, Gigarran-Guldris S, Teruel J, Castelao A, Revilla J, Martinez C, Stanojevic M, Boque E, Rosell M, De Lamo V, Tocados J, Carrasco A, Lopez M, Enriquez M, Bardaji A, Masot N, Gomez A, Sanjuan A, Ortega A, Fuentes R, Guindo M, Fuentes M, Ravassa F, Molina M, Tortosa C, Jacobs-Cacha C, Matamoros O, Meneghini M, Roig J, Betsabe I, Larrea C, Alvarez B, Corte M, Rodrigues-Diez R, Vazquez A, Rodriguez S, Castineira J, Martin C, Alvarez M, Iglesias V, Borra J, Rubio M, Gilsanz G, Cabrera M, Heffernan J, Gonzalez M, Gonzalez O, Garcia M, Correa P, Ramos S, Oliva M, Becerra B, Cabrera C, Mateo G, Villanueva R, Garcia L, Andia J, Martin J, Lopez N, Garcia S, Montes C, Luengas I, Alvarez E, Arias L, Carro B, Virgala J, Barreiro J, Fontan M, Gonzalez A, Barja L, Barreiro A, Arias B, Hernandez A, Varela J, Lechuga J, Rodriguez C, Murias M, de la Iglesia A, Pineiro P, Eijo A, Cachaza N, Blanch N, Martinez A, Val M, Draibe J, Melilli E, Montero A, Perez N, Oliveras X, Barrio M, Santos J, Barrera C, Saez M, Pachon M, Cabrales C, Porras A, Gonzalez V, Mallol L, Puyol D, Torres M, Ongil S, Basilio L, Centenera G, de Miguel P, Rodriguez L, Nadah H, Fernandez M, Chamond M, Fernandez N, Boillos A, Cenarruzabeitia N, Seara M, Dorronsoro I, Moreno P, Lavilla F, Torres A, Miranda D, Redondo E, Porrini E, Caso M, Tamajon M, Hernandez M, Rebollo M, Mallen P, Rinne A, Rodriguez R, Torres S, Sosa D, Cabrera B, Rodriguez N, Gamboa M, de los Angeles C, Lourdes P, Margarita R, Sagrario G, Patricia D, Alejandra A, Maria G, Rosa M, Sara E, Diego A, Beatriz E, Nayara Z, Arminda F, Jose R, Bermejo M, Lucas M, Moreno E, Munoz L, Huertas S, Serrano E, Toro L, Agudo C, Alvarez C, Portoles J, Marques M, Rubio E, Sanchez-Sobrino B, Garcia-Menendez E, Fernandez A, Benitez P, Gallardo M, Juarez G, Martinez E, Terente M, Ribera A, Escribano T, Fontan F, Perez-Monteoliva N, Huerta E, Rodriguez G, Hernandez S, Zamorano S, Gomez J, AIRG-E, EKPF, ALCER, FRIAT, REDINREN, ONT, RICORS2040, SENEFRO, and SET

Subjects
Kidney transplantation, Research funding, Chronic kidney disease, Decade of the kidney, Burden of disease, COVID-19, Kidney failure, Accelerated aging
Abstract

The uptake of the current concept of chronic kidney disease (CKD) by the public, physicians and health authorities is low. Physicians still mix up CKD with chronic kidney insufficiency or failure. In a recent manuscript, only 23% of participants in a cohort of persons with CKD had been diagnosed by their physicians as having CKD while 29% has a diagnosis of cancer and 82% had a diagnosis of hypertension. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. A prevalent view is that for those in whom kidneys fail, the problem is ``solved'' by dialysis or kidney transplantation. However, the main burden of CKD is accelerated aging and all-cause and cardiovascular premature death. CKD is the most prevalent risk factor for lethal COVID-19 and the factor that most increases the risk of death in COVID-19, after old age. Moreover, men and women undergoing KRT still have an annual mortality which is 10-100-fold higher than similar age peers, and life expectancy is shortened by around 40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth global cause of death by 2040 and the second cause of death in Spain before the end of the century, a time when 1 in 4 Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded CIBER network research structure in Spain. Leading Spanish kidney researchers grouped in the kidney collaborative research network REDINREN have now applied for the RICORS call of collaborative research in Spain with the support of the Spanish Society of Nephrology, ALCER and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true. However, only the highest level of research funding through the CIBER will allow to adequately address the issue before it is too late. (C) 2021 Sociedad Espanola de Nefrologia. Published by Elsevier Espana, S.L.U.

Published
2022

4. Activating Technology for Connected Health in Cancer: Protocol for a Research and Training Program.

Author

Mountford N, Dorronzoro Zubiete E, Kessie T, Garcia-Zapirain B, Nuño-Solinís R, Coyle D, Munksgaard KB, Fernandez-Luque L, Rivera Romero O, Mora Fernandez M, Valero Jimenez P, Daly A, Whelan R, and Caulfield B

Abstract

Background: As cancer survival rates increase, the challenge of ensuring that cancer survivors reclaim their quality of life (QoL) becomes more important. This paper outlines the research element of a research and training program that is designed to do just that., Objective: Bridging sectors, disciplines, and geographies, it brings together eight PhD projects and students from across Europe to identify the underlying barriers, test different technology-enabled rehabilitative approaches, propose a model to optimize the patient pathways, and examine the business models that might underpin a sustainable approach to cancer survivor reintegration using technology., Methods: The program, funded under the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 722012, includes deep disciplinary PhD projects, intersectoral and international secondments, interdisciplinary plenary training schools, and virtual subject-specific education modules., Results: The 8 students have now been recruited and are at the early stages of their projects., Conclusions: CATCH will provide a comprehensive training and research program by embracing all key elements-technical, social, and economic sciences-required to produce researchers and project outcomes that are capable of meeting existing and future needs in cancer rehabilitation., (©Nicola Mountford, Enrique Dorronzoro Zubiete, Threase Kessie, Begonya Garcia-Zapirain, Roberto Nuño-Solinís, David Coyle, Kristin B Munksgaard, Luis Fernandez-Luque, Octavio Rivera Romero, Matilde Mora Fernandez, Pedro Valero Jimenez, Ailish Daly, Ruth Whelan, Brian Caulfield. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 24.01.2018.)

Published
2018
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