227 results on '"Moore GP"'
Search Results
2. Does Abdominal Computed Tomugrapby Scanning Change Clinician Decisionmaking Regarding the Diagnosis and Disposition of Emergency Department Patients With Nontraumatic Abdominal Pain?
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Shufflebarger, CM, Kelvin, FM, Frayer, SM, Jones, JB, Maglinte, DD, Moore, GP, Reiger, MA, Bonner, PM, and Brizendine, EJ
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Emergency medicine -- Research ,Health - Published
- 2001
3. Should Parents Be Present During Emergency Department Procedures on Children and Who Should Make That Decision? A Survey of Emergency Physician and Nurse Attitudes
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Sloan, BK, Moore, GP, Beckman, AJ, Brizendine, EJ, and Cordell, WH
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Emergency medical services -- Health aspects ,Children -- Injuries ,Parents -- Psychological aspects ,Health - Published
- 2000
4. Effect of Tubing on High Frequency Ventilation with the Draeger Babylog
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Moore, GP, primary, Wheeler, Kl, additional, Davis, PC, additional, Kamlin, COF, additional, and Morley, CJ, additional
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- 2009
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5. Comparison of Two Respiratory Function Monitors for High Frequency Ventilation
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Moore, GP, primary, Wheeler, Kl, additional, Davis, PC, additional, Kamlin, COF, additional, and Morley, CJ, additional
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- 2009
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6. Repeated Indomethacin Courses in <27 Week Gestational Age Infants With a Patent Ductus Arteriosus: is it Worthwhile?
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Moore, GP, primary, Lawrence, SL, additional, Maharajh, G, additional, Sumner, A, additional, Gaboury, I, additional, and Lemyre, B, additional
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- 2009
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7. Should parents be present during emergency department procedures on children, and who should make that decision? A survey of emergency physician and nurse attitudes.
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Beckman AW, Sloan BK, Moore GP, Cordell WH, Brizendine EJ, Boie ET, Knoop KJ, Goldman MJ, Geninatti MR, and P5 (Parental Presence During Painful Pediatric Procedures) Research Group
- Published
- 2002
8. Ethics seminars: the practice of medical procedures on newly dead patients -- is consent warranted?
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Moore GP
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- 2001
9. A preliminary report on treatment of contact granuloma with steroid injections.
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Crary MA, Sapienza CM, Cassisi NJ, and Moore GP
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- 1998
10. Comparison of intravenous, intraosseous, and intramuscular administration of succinylcholine in sheep
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Moore, GP, primary, Pace, SA, additional, and Busby, W, additional
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- 1989
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11. Comparison of intraosseous versus intravenous loading of phenytoin in pigs and effect on bone marrow
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Vinsel, PJ, primary, Moore, GP, additional, and O'Hair, KC, additional
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- 1989
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12. Proceedings: Reactivation of RNA synthesis in macropod embryos after diapause
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Moore Gp
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Macropodidae ,Embryology ,Obstetrics and Gynecology ,Embryo ,Cell Biology ,Biology ,Diapause ,Cell biology ,Toxicology ,Marsupialia ,Endocrinology ,Reproductive Medicine ,Pregnancy ,Animals ,RNA ,Female - Published
- 1976
13. Overnight staffing in Canadian neonatal and pediatric intensive care units.
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Maratta C, Hutchison K, Nicoll J, Bagshaw SM, Granton J, Kirpalani H, Stelfox HT, Ferguson N, Cook D, Parshuram CS, and Moore GP
- Abstract
Aim: Infants and children who require specialized medical attention are admitted to neonatal and pediatric intensive care units (ICUs) for continuous and closely supervised care. Overnight in-house physician coverage is frequently considered the ideal staffing model. It remains unclear how often this is achieved in both pediatric and neonatal ICUs in Canada. The aim of this study is to describe overnight in-house physician staffing in Canadian pediatric and level-3 neonatal ICUs (NICUs) in the pre-COVID-19 era., Methods: A national cross-sectional survey was conducted in 34 NICUs and 19 pediatric ICUs (PICUs). ICU directors or their delegates completed a 29-question survey describing overnight staffing by resident physicians, fellow physicians, nurse practitioners, and attending physicians. A comparative analysis was conducted between ICUs with and without in-house physicians., Results: We obtained responses from all 34 NICUs and 19 PICUs included in this study. A total of 44 ICUs (83%) with in-house overnight physician coverage provided advanced technologies, such as extracorporeal life support, and included all ICUs that catered to patients with cardiac, transplant, or trauma conditions. Residents provided the majority of overnight coverage, followed by the Critical Care Medicine fellows. An attending physician was in-house overnight in eight (15%) out of the 53 ICUs, seven of which were NICUs. Residents participating in rotations in the ICU would often have rotation durations of less than 6 weeks and were often responsible for providing care during shifts lasting 20-24 h., Conclusion: Most PICUs and level-3 NICUs in Canada have a dedicated in-house physician overnight. These physicians are mainly residents or fellows, but a notable variation exists in this arrangement. The potential effects on patient outcomes, resident learning, and physician satisfaction remain unclear and warrant further investigation., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2023 Maratta, Hutchison, Nicoll, Bagshaw, Granton, Kirpalani, Stelfox, Ferguson, Cook, Parshuram and Moore.)
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- 2023
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14. Extremely premature birth bioethical decision-making supported by dialogics and pragmatism.
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Kaempf JW and Moore GP
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- Pregnancy, Female, Humans, Morals, Uncertainty, Delivery of Health Care, Cultural Diversity, Premature Birth
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Moral values in healthcare range widely between interest groups and are principally subjective. Disagreements diminish dialogue and marginalize alternative viewpoints. Extremely premature births exemplify how discord becomes unproductive when conflicts of interest, cultural misunderstanding, constrained evidence review, and peculiar hierarchy compete without the balance of objective standards of reason. Accepting uncertainty, distributing risk fairly, and humbly acknowledging therapeutic limits are honorable traits, not relativism, and especially crucial in our world of constrained resources. We think dialogics engender a mutual understanding that: i) transitions beliefs beyond bias, ii) moves conflict toward pragmatism (i.e., the truth of any position is verified by subsequent experience), and iii) recognizes value pluralism (i.e., human values are irreducibly diverse, conflicting, and ultimately incommensurable). This article provides a clear and useful Point-Counterpoint of extreme prematurity controversies, an objective neurodevelopmental outcomes table, and a dialogics exemplar to cultivate shared empathetic comprehension, not to create sides from which to choose. It is our goal to bridge the understanding gap within and between physicians and bioethicists. Dialogics accept competing relational interests as human nature, recognizing that ultimate solutions satisfactory to all are illusory, because every choice has downside. Nurturing a collective consciousness via dialogics and pragmatism is congenial to integrating objective evidence review and subjective moral-cultural sentiments, and is that rarest of ethical constructs, a means and an end., (© 2023. The Author(s).)
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- 2023
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15. Assessing shared decision making during antenatal consultations regarding extreme prematurity.
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Ding S, Bijelić V, Daboval T, Dunn S, Lemyre B, Barrowman N, and Moore GP
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- Humans, Female, Infant, Newborn, Pregnancy, Prospective Studies, Retrospective Studies, Referral and Consultation, Infant, Extremely Premature, Decision Making, Decision Making, Shared, Infant, Newborn, Diseases
- Abstract
Objective: To assess whether antenatal decisions regarding the neonatal care at birth for extremely preterm infants are more likely to be made when using shared decision-making (SDM)-style consultations compared to standard consultations., Study Design: In 2015, we implemented a clinical practice guideline promoting SDM use within antenatal consultations in our single-centre university-based perinatal unit. We conducted a prospective cohort study with a retrospective chart review based on data collected from all pregnant women presenting to obstetrical triage between 22 + 0 and 25 + 6 weeks gestation between September 2015 and June 2018., Result: Two-hundred-and-seventeen cases presented; 137 received antenatal consultations with 82 (60%) being SDM-style. Decisions were frequently made (88%; 120/137) after the consultations, with no significant difference between consultation style (RR 1.08, 95% CI [0.95-1.26], p = 0.28)., Conclusion: The provision of either an SDM-style or a standard antenatal consultation seemed to comparably facilitate the reaching of a care decision., (© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.)
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- 2023
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16. An e-Delphi study on mode of delivery and extremely preterm breech singletons.
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Marseu A, Santaguida P, Moore GP, and McDonald SD
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- Infant, Newborn, Pregnancy, Infant, Female, Humans, Infant, Extremely Premature, Cesarean Section, Delphi Technique, Gestational Age, Delivery, Obstetric, Breech Presentation therapy
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Objectives: To understand clinicians' consensus on mode of delivery in extremely preterm breech infants; assess knowledge on neonatal outcomes and its impact on consensus., Study Design: A two-round Delphi of obstetrical or neonatal care providers, recruited from national conferences and investigator networks. Round one assessed decision-making (vignettes), and knowledge; the second round reassessed vignettes after presenting outcome data., Results: In round one (102 respondents), consensus (a priori, ≥75% agreement) was achieved in 4/13 vignettes: two when likely/very likely to offer Cesarean (26 and 27 weeks) and two for unlikely/very unlikely (23 weeks growth restriction, ± adverse features). Clinicians generally underestimated neonatal outcomes. In round two (87 respondents), three scenarios achieved consensus (likely/very likely to offer Cesarean at 25-27 weeks); in five other vignettes, not offering Cesarean was reduced in ≥15% of respondents., Conclusion: Limited consensus exists on extremely preterm breech mode of delivery, partly associated with neonatal outcome underestimation., Gestational Age Notation: The authors follow the World Health Organization's notation on gestational age. Under this notation, the first day of the last menstrual period (LMP) is day 0 of week 0. Therefore, days 0-6 represent completed week 0, days 7-13 represent completed week 1 and so on., (© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.)
- Published
- 2023
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17. Evaluating parental perceptions of written handbooks provided during shared decision making with parents anticipating extremely preterm birth.
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Mardian E, Bucking S, Dunn S, Lemyre B, Daboval T, and Moore GP
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- Decision Making, Decision Making, Shared, Female, Humans, Infant, Extremely Premature, Infant, Newborn, Parents psychology, Pregnancy, Prospective Studies, Premature Birth psychology
- Abstract
Objective: To explore parental perceptions of written handbooks provided to them during antenatal counseling for anticipated extremely preterm birth., Study Design: This study involved a prospective convenience sample of parents anticipating delivery between 22 weeks + 0 days and 25 weeks + 6 days gestation. The antenatal counseling involved a shared decision-making process. In-person interviews were conducted using a semi-structured interview guide to gather feedback about new parent handbooks developed to support decision making. The questions during the semi-structured interview targeted seven main themes: overall impression, timing, graphs/tables, formatting, imagery, ease of use and understanding, and content. The interviews followed an antenatal consultation and provision of the appropriate handbook(s) by a neonatologist. Interviews were transcribed verbatim and thematic analysis of the data was completed., Results: Eleven parents were interviewed. All parents described the provision of the handbook(s) following the consultation with a neonatologist as the ideal time. All parents considered a visual representation of the data to be invaluable. Parents considered the handbooks easy to understand and straightforward. Some parents were satisfied with simple information, which helped them feel less overwhelmed; others felt the depth of information was insufficient. Parents preferred a paper copy to electronic. Reactions to the photo of an infant receiving intensive care varied; some parents felt frightened, others felt comforted., Conclusion: Overall, parents positively evaluated the handbooks, supporting their utility for parents anticipating extremely preterm birth. Concrete suggestions for improvement were made; the handbooks will be modified accordingly. Parents at other perinatal centers may benefit from receiving such handbooks.
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- 2022
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18. Charting Practices to Protect Against Malpractice: Case Reviews and Learning Points.
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Ghaith S, Moore GP, Colbenson KM, and Lindor RA
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- Documentation, Humans, Liability, Legal, Malpractice, Physicians
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Introduction: Medical documentation issues play a role in 10-20% of medical malpractice lawsuits. Inaccurate, incomplete, or generic records undermine a physician's defense and make a plaintiff's lawyer more likely to take on a case. Despite the frequency of documentation errors in malpractice suits, physicians receive very little education or feedback on their documentation. Our objective in this case series was to evaluate malpractice cases related to documentation to help improve physicians' documentation and minimize their liability risks., Methods: We used Thomson Reuters Westlaw legal database to identify malpractice cases related to documentation. Common issues related to documentation and themes in the cases were identified and highlighted., Results: We classified cases into the following categories: incomplete documentation; inaccurate text; transcription errors; judgmental language; and alteration of documentation. By evaluating real cases, physicians can better understand common errors of other practitioners and avoid these in their own practice., Conclusion: Emergency physicians can reduce their liability risks by relying less on forms and templates and making a habit of documenting discussions with the patients, recording others' involvement in patient care (chaperones, consultants, trainees, etc.), addressing others' notes (triage staff, nurses, residents, etc.), paying attention to accuracy of transcribed or dictated information, avoiding judgmental language, and refraining from altering patient charts.
- Published
- 2022
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19. Survival after self-poisoning with sodium nitrite: A case report.
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Matin AM, Boie ET, and Moore GP
- Abstract
Sodium nitrite ingestion poses a considerable public health threat. The incidence of sodium nitrite self-poisoning in the United States has been trending upward since 2017. Our case report describes an intentional sodium nitrite ingestion with favorable outcomes. We highlight the proper treatment of this ingestion with intravenous methylene blue. Sodium nitrite is an oxidizing agent that is commonly found in processed meats, fish, and cheeses as a preservative, antimicrobial, and food coloring agent. It is an odorless, white crystalline powder that has been confused for table salt or granulated sugar. It has become more readily available in large quantities online. Unfortunately, online forums exist that detail how to dose sodium nitrite for suicide. Furthermore, it has been recently discussed in popular news streams after a celebrity died of an overdose. Sodium nitrite toxicity is capable of causing severe methemoglobinemia with high mortality. Prompt identification is crucial. We discuss the important implications in regard to media coverage, imitative suicide, and accessibility of sodium nitrite., Competing Interests: The authors declare no conflicts of interest., (© 2022 The Authors. JACEP Open published by Wiley Periodicals LLC on behalf of American College of Emergency Physicians.)
- Published
- 2022
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20. Let's Be Honest: These Medical Malpractice Cases Were a Pain in the Back.
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Garcia SI, Ghiath S, Moore GP, Lindor RA, and Hevesi S
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Introduction: This series reviews three cases of back pain where a highly morbid diagnosis was missed by an emergency physician and subsequently successfully litigated., Case Report: We review the clinical entities of spinal epidural abscess and cauda equina syndrome, challenging diagnoses that can be easily missed and lead to patient harm if not treated promptly. Here we offer suggestions for recognizing these conditions quickly, performing an adequate history and exam, and using documentation to support decision-making., Conclusion: When confronted with an unfortunate medical outcome, maintaining honesty is of paramount importance in medical-legal environments.
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- 2022
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21. Three Cases of Emergency Department Medical Malpractice Involving "Consultations": How Is Liability Legally Determined?
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Aldalati A, Bellamkonda VR, Moore GP, and Finch AS
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This article presents three successfully litigated medical malpractice cases involving emergency physicians and consultants. We discuss the respective case medical diagnoses, as well as established legal principles that determine in a court proceeding which provider will be liable. Specifically, we explain the legal principles of "patient physician relationship" and "affirmative act."
- Published
- 2021
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22. Physician and Pharmacist Liability: Medicolegal Cases That are Tough Pills to Swallow.
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Schupbach JCS, Kaisler MC, Moore GP, and Sandefur BJ
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We present four medicolegal cases involving medication errors, which led to patient harm and subsequent settlements or jury awards to patients. These cases each involved scenarios in which a medication was inappropriately prescribed and/or inappropriately dispensed. In such cases, it is often not obvious whether the physician or pharmacist is at fault. These cases highlight the importance of understanding the roles and responsibilities of the physician and pharmacist in medication prescription and dispensation.
- Published
- 2021
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23. Evaluating the impact of CPAP weaning procedures on total days on nasal CPAP: A retrospective chart review.
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Puthattayil ZB, Moore GP, Tang K, Huneault-Purney N, and Lawrence SL
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- Humans, Infant, Infant, Newborn, Continuous Positive Airway Pressure, Retrospective Studies, Ventilator Weaning, Infant, Premature, Respiratory Distress Syndrome, Newborn
- Abstract
Background: There is no consensus on how to wean infants from Nasal Continuous Positive Airway Pressure (NCPAP). We hypothesized that ceasing NCPAP abruptly would decrease the duration required, compared with a gradual wean., Methods: This retrospective chart review included preterm infants requiring NCPAP for over 48 hours. Cohort1 weaned NCPAP by cycling on and off, while cohort 2 ceased NCPAP abruptly. The primary outcome was total days on NCPAP. Secondary outcomes included rate of bronchopulmonary dysplasia, weight gain, duration of hospital stay, and compliance with the use of stability criteria., Results: 81 infants met inclusion criteria in cohort one, and 89 in cohort two. Median days on NCPAP were 17.0 and 11.0 days, respectively, not significant. There was no significant difference in secondary outcomes., Conclusions: There was no significant association between the two NCPAP weaning protocols and the outcomes studied.
- Published
- 2021
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24. In-House, Overnight Physician Staffing: A Cross-Sectional Survey of Canadian Adult ICUs.
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Maratta C, Hutchison K, Moore GP, Bagshaw SM, Granton J, Kirpalani H, Stelfox HT, Ferguson N, Cook D, and Parshuram CS
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- Canada, Cross-Sectional Studies, Humans, Intensive Care Units statistics & numerical data, Internship and Residency organization & administration, Internship and Residency statistics & numerical data, Medical Staff, Hospital organization & administration, Medical Staff, Hospital statistics & numerical data, Personnel Staffing and Scheduling organization & administration, Personnel Staffing and Scheduling statistics & numerical data, Surveys and Questionnaires, Intensive Care Units organization & administration
- Abstract
Objectives: Overnight physician staffing in the ICU has been recommended by the Society of Critical Care Medicine and the Leapfrog Consortium. We conducted a survey to review practice in the current era and to compare this with results from a 2006 survey., Design: Cross-sectional survey., Setting: Canadian adult ICUs., Participants: ICU directors., Interventions: None., Measurement and Main Results: A 29-question survey was sent to ICU directors describing overnight staffing by residents, fellows, nurse practitioners, and staff physicians, as well as duty duration, clinical responsibilities, and unit characteristics. We established contact with 122 ICU directors, of whom 107 (88%) responded. Of the 107 units, 60 (56%) had overnight in-house physicians. Compared with ICUs without overnight in-house physician coverage, ICUs with in-house physicians were in larger hospitals (p < 0.0001), had more beds (p < 0.0001), had more ventilated patients (p < 0.0001), and had more admissions (p < 0.0001). Overnight in-house physicians were first year residents (R1) in 20 of 60 (33%), second to fifth year residents (R2-R5) in 46 of 60 (77%), and Critical Care Medicine trainees in 19 of 60 (32%). Advanced practice nurses provided overnight coverage in four of 107 ICUs (4%). The most senior in-house physician was a staff physician in 12 of 60 ICUs (20%), a Critical Care Medicine trainee in 14 of 60 (23%), and a resident (R2-R5) in 20 of 60 (33%). The duration of overnight duty was on average 20-24 hours in 22 of 46 units (48%) with R2-R5 residents and 14 of 19 units (74%) covered by Critical Care Medicine trainees., Conclusions: Variability of in-house overnight physician presence in Canadian adult ICUs is linked to therapeutic complexity and unit characteristics and has not changed significantly over the decade since our 2006 survey. Additional evidence about patient and resident outcomes would better inform decisions to revise physician scheduling in Canadian ICUs.
- Published
- 2020
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25. Three Medicolegal Cases of Searching for the Stone: Lessons Learned Along the Journey.
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Jacobson AA, Sakamoto AE, Moore GP, and Boie ET
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We present three medicolegal cases of medical negligence settled out of court. These cases all involved patients who presented to the emergency department (ED) with a suspected diagnosis of kidney stone. Highlighted are the importance of patient communication, addressing incidental findings found during a patient's ED visit, anticipating complications, and the need for thorough documentation.
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- 2020
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26. Seeking Normalcy as the Curve Flattens: Ethical Considerations for Pediatricians Managing Collateral Damage of Coronavirus Disease-2019.
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Feltman DM, Moore GP, Beck AF, Siffermann E, Bellieni C, and Lantos J
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- Betacoronavirus, Biomedical Research ethics, COVID-19, Health Priorities, Healthcare Disparities, Humans, Mental Health, Morals, Needs Assessment, Pandemics, Psychological Distress, SARS-CoV-2, Social Determinants of Health, Socioeconomic Factors, Coronavirus Infections epidemiology, Coronavirus Infections psychology, Pediatricians ethics, Pneumonia, Viral epidemiology, Pneumonia, Viral psychology
- Published
- 2020
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27. Neurodevelopmental outcome descriptions in cohorts of extremely preterm children.
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Ding S, Mew EJ, Chee-A-Tow A, Offringa M, Butcher NJ, and Moore GP
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- Child, Data Accuracy, Female, Gestational Age, Humans, Male, Prospective Studies, Research Design, Cerebral Palsy epidemiology, Cognitive Dysfunction epidemiology, Infant, Extremely Premature growth & development, Infant, Premature, Diseases epidemiology, Neurodevelopmental Disorders epidemiology
- Abstract
Background and Objectives: Caregivers and clinicians of extremely preterm infants (born before 26 weeks' gestation) depend on long-term follow-up research to inform clinical decision-making. The completeness of outcome reporting in this area is unknown. The objective of this study was to evaluate the reporting of outcome definitions, selection, measurement and analysis in existing cohort studies that report on neurodevelopmental outcomes of children born extremely preterm., Methods: We evaluated the completeness of reporting of 'cognitive function' and 'cerebral palsy' in prospective cohort studies summarised in a meta-analysis that assessed the effect of preterm birth on school-age neurodevelopment. Outcome reporting was evaluated using a checklist of 55 items addressing outcome selection, definition, measurement, analysis, presentation and interpretation. Reporting frequencies were calculated to identify strengths and deficiencies in outcome descriptions., Results: All 14 included studies reported 'cognitive function' as an outcome; nine reported both 'cognitive function' and 'cerebral palsy' as outcomes. Studies reported between 26% and 46% of the 55 outcome reporting items assessed; results were similar for 'cognitive function' and 'cerebral palsy' (on average 34% and 33% of items reported, respectively). Key methodological concepts often omitted included the reporting of masking of outcome assessors, methods used to handle missing data and stakeholder involvement in outcome selection., Conclusions: The reporting of neurodevelopmental outcomes in cohort studies of infants born extremely preterm is variable and often incomplete. This may affect stakeholders' interpretation of study results, impair knowledge synthesis efforts and limit evidence-based decision-making for this population., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2020
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28. Paediatric ethical issues during the COVID-19 pandemic are not just about ventilator triage.
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Haward MF, Moore GP, Lantos J, and Janvier A
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- COVID-19, Child, Coronavirus Infections epidemiology, Health Care Rationing ethics, Humans, Infant, Infant, Newborn, Pneumonia, Viral epidemiology, Triage ethics, Ventilators, Mechanical supply & distribution, Coronavirus Infections therapy, Pandemics, Pediatrics ethics, Pneumonia, Viral therapy
- Published
- 2020
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29. Should Extremely Premature Babies Get Ventilators During the COVID-19 Crisis?
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Haward MF, Janvier A, Moore GP, Laventhal N, Fry JT, and Lantos J
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- Aged, COVID-19, Female, Humans, Infant, Newborn, Male, Pandemics ethics, SARS-CoV-2, Betacoronavirus, Coronavirus Infections therapy, Infant, Extremely Premature, Pneumonia, Viral therapy, Respiration, Artificial ethics, Triage ethics
- Abstract
In a crisis, societal needs take precedence over a patient's best interests. Triage guidelines, however, differ on whether limited resources should focus on maximizing lives or life-years. Choosing between these two approaches has implications for neonatology. Neonatal units have ventilators, some adaptable for adults. This raises the question of whether, in crisis conditions, guidelines for treating extremely premature babies should be altered to free-up ventilators. Some adults who need ventilators will have a survival rate higher than some extremely premature babies. But surviving babies will likely live longer, maximizing life-years. Empiric evidence demonstrates that these babies can derive significant survival benefits from ventilation when compared to adults. When "triaging" or choosing between patients, justice demands fair guidelines. Premature babies do not deserve special consideration; they deserve equal consideration. Solidarity is crucial but must consider needs specific to patient populations and avoid biases against people with disabilities and extremely premature babies.
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- 2020
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30. Autosomal dominant transmission of transient neonatal lactic acidosis: a case report.
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Mardian EB, Lines MA, and Moore GP
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- Female, Humans, Infant, Newborn, Acidosis, Acidosis, Lactic etiology, Acidosis, Lactic genetics, Infant, Newborn, Diseases diagnosis, Infant, Newborn, Diseases genetics, Mitochondrial Diseases diagnosis, Mitochondrial Diseases genetics
- Abstract
Background: Lactic acidosis is a common finding in neonates, in whom mitochondrial dysfunction is often secondary to tissue hypoperfusion, respiratory failure, and/or sepsis. Primary (non-physiological) lactic acidosis is comparatively rare, and suggests the presence of an inborn error of mitochondrial energy metabolism. Optimal medical management and accurate prognostication requires the correct determination of the etiology of lactic acidosis in a given patient. Unfortunately, genetic diagnoses are rare and highly variable for neonates presenting with primary lactic acidosis; individual case reports may offer the most promise for treatment considerations. The mitochondrion is a complex molecular machine incorporating the products of > 1000 distinct nuclear genes. Primary lactic acidoses are therefore characterized by high genetic heterogeneity and a specific genetic diagnosis currently remains out of reach in most cases. Most mitochondriopathies with neonatal onset follow autosomal recessive inheritance and carry a poor prognosis. Here we detail the case of a father and daughter with dominantly-inherited, resolving (i.e. transient) neonatal hyperlactatemia due to complex IV deficiency. We found no other published descriptions of benign transient complex IV deficiency with autosomal dominant inheritance., Case Presentation: Both individuals presented as neonates with unexplained, marked lactic acidosis suggesting a primary mitochondrial disorder. Within the first weeks of life, elevated blood lactate levels normalized. Their clinical and developmental outcomes were normal. Biochemical studies in the proband showed multiple abnormalities consistent with a complex IV respiratory chain defect. Cultured skin fibroblasts showed an elevated lactate-to-pyruvate ratio, deficient complex IV activity, and normal pyruvate dehydrogenase and pyruvate carboxylase activities. Whole-exome sequencing of the proband and both parents did not identify a causative mutation., Conclusion: We conclude that the proband and her father appear to have a dominant form of transient neonatal hyperlactatemia due to heterozygous changes in an as-yet unidentified gene. This transient neonatal complex IV deficiency should be considered in the differential diagnosis of primary neonatal hyperlactatemia; notable clinical features include autosomal-dominant inheritance and an apparently benign postnatal course. This report exemplifies the growing differential diagnosis for neonatal lactic acidosis and highlights the importance of both physician counselling and the use of family history in communicating with parents.
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- 2020
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31. Do transport factors increase the risk of severe brain injury in outborn infants <33 weeks gestational age?
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Redpath S, Shah PS, Moore GP, Yang J, Toye J, Perreault T, and Lee KS
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- Brain pathology, Canada, Cerebral Intraventricular Hemorrhage etiology, Humans, Infant, Newborn, Logistic Models, Multivariate Analysis, Retrospective Studies, Risk Factors, Cerebral Hemorrhage etiology, Infant, Premature, Infant, Premature, Diseases, Transportation of Patients
- Abstract
Objective: We evaluated transport factors and postnatal practices to identify modifiable risk factors for SBI., Study Design: Retrospective review of Canadian Neonatal Transport Network data linked to Canadian Neonatal Network data for outborns <33 weeks gestational age (GA), during January 2014 to December 2015. SBI was defined as grade 3 or 4 intraventricular hemorrhage or parenchymal echogenicity, including hemorrhagic and/or ischemic lesions., Result: Among 781 infants, 115 (14.7%) had SBI with range 5.6-40% among transport teams. In multivariable analysis, SBI was associated with GA [0.77 (0.71, 0.85)] per week, receipt of chest compressions and/or epinephrine at delivery [1.81 (1.08, 3.05)] and receipt of fluid boluses [1.61 (1.00, 2.58)]., Conclusions: Risk factors for SBI were related to the condition at birth and immediate postnatal management and not related to transport factors. These results highlight the importance of maternal transfer to perinatal centers to allow optimization of perinatal management.
- Published
- 2020
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32. A meta-analysis of neurodevelopmental outcomes at 4-10 years in children born at 22-25 weeks gestation.
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Ding S, Lemyre B, Daboval T, Barrowman N, and Moore GP
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- Child, Child, Preschool, Gestational Age, Humans, Infant, Newborn, Infant, Extremely Premature, Neurodevelopmental Disorders epidemiology
- Abstract
Aim: To update our meta-analysis on neurodevelopmental disability rates in children born at 22-25 weeks gestation. The main outcome measure was rates of neurodevelopmental disability in survivors at age 4-10 years., Methods: We used a peer-reviewed electronic and grey search to identify articles. Two authors independently reviewed cohorts published after May 2012 with: born ≥1995 in a developed nation; assessed at 4-10 years; prospective; >65% follow-up; definitions for neurodevelopmental disability as per the EPICure cohort; results reported by gestation. We contacted authors for clarification. Random effects meta-analysis was used to estimate pooled proportions of neurodevelopmental disability. Within each study, the absolute change in proportions with each week was estimated and then pooled., Results: We reviewed 3980 records; 21 articles were assessed and six were included. With the previous 9 cohorts, the meta-analysis now contains 15. Rates of moderate-to-severe neurodevelopmental disability were as follows: 42% (95% CI 23,64%; I
2 0%) at 22; 41% (95% CI 31,52%; I2 20%) at 23; 32% (95% CI 25,39%; I2 45%) at 24; 23% (95% CI 18,29%; I2 60%) at 25 weeks. The analysis shows a significant decrease in risk of moderate-to-severe neurodevelopmental disability between each week (8.1% (95% CI -11.8, -4.5%); I2 0%; p < 0.001)., Conclusion: Physicians can use this high-quality data to support parents during decision-making., (©2018 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.)- Published
- 2019
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33. Shared decision making during antenatal counselling for anticipated extremely preterm birth.
- Author
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Barker C, Dunn S, Moore GP, Reszel J, Lemyre B, and Daboval T
- Abstract
Objectives: To explore health care providers' (HCPs) perceptions of using shared decision making (SDM) and to identify facilitators of and barriers to its use with families facing the anticipated birth of an extremely preterm infant at 22
+0 to 25+6 weeks gestational age., Study Design: Qualitative descriptive study design: we conducted interviews with 25 HCPs involved in five cases at a tertiary care centre and completed qualitative content analysis of their responses., Results: Nine facilitators and 16 barriers were identified. Facilitators included: a correct understanding of this process and how to apply it, a belief that parents should be the decision makers in these situations, and a positive outlook toward using SDM during antenatal counselling. Barriers included: HCPs' misunderstandings of how and when to apply SDM during antenatal counselling, challenges using the process for cases at the lower end of the gestational age range, fear of the negative emotions and stress parents face when making decisions, and HCPs' uncertainty about their ability to properly apply SDM., Conclusions: This study identified facilitators and barriers to use of SDM during antenatal counselling for anticipated birth of extremely preterm infants that can be used to inform development of tailored strategies to facilitate future implementation of shared decision making in this area.- Published
- 2019
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34. Needs assessment of ethics and communication teaching for neonatal perinatal medicine programs in Canada.
- Author
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Daboval T, Ferretti E, Moussa A, van Manen M, Moore GP, Srinivasan G, Moldovan A, Agarwal A, and Albersheim S
- Abstract
Objective: To explore ethics education needs in Canadian Neonatal Perinatal Medicine (NPM) training programs., Methods: A retrospective review of NPM trainees' performance at the National NPM Objective Structured Clinical Examination (OSCE) was undertaken for 2012 to 2017 and two distinct cross-sectional online surveys were carried out. One survey targeted recently graduated neonatologists (RGNs) who completed 2 years' training in a Canadian NPM program between 2010 and 2015; the other survey was sent to Canadian NPM training program directors (PDs). The domains of interest were: perception of education, ethics and communication topics, educational strategies, assessment of trainees' competencies, and barriers to neonatal ethics education., Results: NPM trainees generally performed less well in stations involving ethics and communication relative to other domains on the National OSCE. Forty-seven RGNs (44.3%) and 12 PDs (92.3%) completed the survey. Over 90% of PDs and RGNs agreed on the importance of training in ethics and communication. Both groups highly valued training on topics related to communication. Preferred teaching strategies were experiential: observation and feedback. PDs mentioned the importance of using validated tools to regularly and formally assess trainees. They recognized challenges in regard to financial resources, physical space, and faculty training in patient-physician communication., Conclusions: National OSCE results indicate the need to improve neonatal ethics and communication training in Canadian NPM programs. RGNs and PDs identified important topics, as well as teaching and evaluation strategies. These results can be used to develop a training program for ethics and communication in NPM.
- Published
- 2019
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35. Catch the moment: The power of turning mistakes into 'precious' learning opportunities.
- Author
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Ferretti E, Rohde K, Moore GP, and Daboval T
- Abstract
We developed a series of small group workshops that aim to facilitate communication during very challenging ethically sensitive scenarios within a Neonatal-Perinatal Medicine (NPM) postgraduate curriculum at the University of Ottawa. These workshops are called Scenario-Oriented Learning in Ethics (SOLE). This educational intervention aims to focus attention on the learner's needs and to help them recognize, define, and view each communicative or behavioural mistake as an occasion to achieve a personal-defined learning goal in a controlled environment free of judgement. The goal of this commentary is to describe the importance of timely interruptions during the scenarios allowing mini concurrent-guided debriefing-feedback by focusing upon trainees' communication mistakes, utilizing them as valuable learning opportunities.
- Published
- 2019
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36. Testing a Communication Assessment Tool for Ethically Sensitive Scenarios: Protocol of a Validation Study.
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Daboval T, Ward N, Schoenherr JR, Moore GP, Carew C, Lambrinakos-Raymond A, and Ferretti E
- Abstract
Background: Although well-designed instruments to assess communication during medical interviews and complex encounters exist, assessment tools that differentiate between communication, empathy, decision-making, and moral judgment are needed to assess different aspects of communication during situations defined by ethical conflict. To address this need, we developed an assessment tool that differentiates competencies associated with practice in ethically challenging situations. The competencies are grouped into three distinct categories: communication skills, civility and respectful behavior, clinical and ethical judgment and decision-making., Objective: The overall objective of this project is to develop an assessment tool for ethically sensitive scenarios that measures the degree of respect for the attitudes and beliefs of patients and family members, the demands of clinical decision-making, and the success in dealing with ethical conflicts in the clinical context. In this article, we describe the research method we will use during the pilot-test study using the neonatal context to provide validity evidence to support the features of the Assessment Communication Tool for Ethics (ACT4Ethics) instrument., Methods: This study is part of a multiphase project designed according to modern validity principles including content, response process, internal structure, relation to other variables, and social consequences. The design considers threats to validity such as construct underrepresentation and factors exerting nonrandom influence on scores. This study consists of two primary steps: (1) train the raters in the use of the new tool and (2) pilot-test a simulation using an Objective Structured Clinical Examination. We aim to obtain a total of 90 independent assessments based on the performance of 30 trainees rated by 15 trained raters for analysis. A comparison of raters' responses will allow us to compute a measure of interrater reliability. We will additionally compare the results of ACT4Ethics with another existing instrument., Results: This study will take approximately 18 months to complete and the results should be available by September 2019., Conclusions: ACT4Ethics should allow clinician-teachers to assess and monitor the development of competency of trainees' judgments and communication skills when facing ethically sensitive clinical situations. The instrument will also guide the provision of meaningful feedback to ensure that trainees develop specific communication, empathy, decision-making, and ethical competencies., International Registered Report Identifier (irrid): PRR1-10.2196/12039., (©Thierry Daboval, Natalie Ward, Jordan R Schoenherr, Gregory P Moore, Caitlin Carew, Alicia Lambrinakos-Raymond, Emanuela Ferretti. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 08.05.2019.)
- Published
- 2019
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37. A Pair of Testicular Torsion Medicolegal Cases with Caveats: The Ball's in Your Court.
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Bass JB, Couperus KS, Pfaff JL, and Moore GP
- Abstract
In this article, we present two medicolegal cases illustrating medical and diagnostic pitfalls that can lead to litigation for missed testicular torsion. Testicular torsion (TT) is a urologic emergency with potentially devastating consequences and costs, for providers and patients alike. TT occurs in approximately 4.5 per 100,000 males under the age of 25. While uncommon, TT is the third most common cause of medical malpractice suits in this demographic. As a consequence of varying presentations and physical exam findings, and diagnostic imaging subject to individual interpretation, this time-sensitive diagnosis may be missed by emergency department providers. Delays in diagnosis significantly increases the morbidity associated with TT, and 31.9%-41.9% of such cases result in testicular loss. The average reported settlement for TT malpractice litigation is $60,000. This article discusses two actual malpractice cases involving TT and provides insight and caveats to ensure an optimal evaluation and diagnostic approach to this often-elusive condition., Competing Interests: Conflicts of Interest: By the CPC-EM article submission agreement, all authors are required to disclose all affiliations, funding sources and financial or management relationships that could be perceived as potential sources of bias. The view(s) expressed herein are those of the author(s) and do not reflect the official policy or position of Madigan Army Medical Center, the U.S. Army Medical Department, the U.S. Army Office of the Surgeon General, the Department of the Air Force, the Department of the Army or the Department of Defense or the U.S.
- Published
- 2018
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38. Patient with a Subarachnoid Headache.
- Author
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Montemayor ET, Long B, Pfaff JA, and Moore GP
- Abstract
Subarachnoid hemorrhage (SAH) is a life-threatening cause of headache. The diagnostic approach to this entity continues to evolve with a recent questioning of the classic workup of computed tomography and lumbar puncture. We report a risk management case of a patient with a missed SAH resulting in a fatal outcome. When there are multiple diagnostic strategies, the patient may be involved with shared decision-making. Some of the medical and legal implications of the diagnosis of SAH will be discussed., Competing Interests: Conflicts of Interest: By the CPC-EM article submission agreement, all authors are required to disclose all affiliations, funding sources and financial or management relationships that could be perceived as potential sources of bias. The authors disclosed none. The view(s) expressed herein are those of the author(s) and do not reflect the official policy or position of Brooke Army Medical Center, the U.S. Army Medical Department, the U.S. Army Office of the Surgeon General, the Department of the Air Force, the Department of the Army or the Department of Defense or the U.S. Government.
- Published
- 2018
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39. Antenatal Consultations at Extreme Prematurity: A Systematic Review of Parent Communication Needs.
- Author
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Kharrat A, Moore GP, Beckett S, Nicholls SG, Sampson M, and Daboval T
- Subjects
- Female, Health Personnel, Humans, Infant, Extremely Premature, Infant, Newborn, Male, Parents, Patient Education as Topic, Patient Participation, Patient Satisfaction, Practice Guidelines as Topic, Pregnancy, Prenatal Care, Professional-Patient Relations, Qualitative Research, Communication, Decision Making, Infant, Newborn, Diseases diagnosis
- Abstract
Objective: To synthesize and describe parental expectations on how healthcare professionals should interact with them during a peripartum, antenatal consultation for extremely preterm infants., Study Design: For this systematic literature review with textual narrative synthesis, we included studies that explored parental perspectives regarding the antenatal consultation for an extremely preterm infant. Electronic searches of Medline, CINAHL, PsycInfo, and Embase were conducted, along with a search of the grey literature. Quality appraisal was conducted using the guide by Walsh and Downe. Two independent reviewers reviewed 783 titles, of which 130 abstracts then 40 full-text articles were reviewed. Final data abstraction includes 19 studies. We predetermined 6 topics of interest (setting, timing, preferred healthcare professional, information, resources, and parents-physician interaction) to facilitate thematic analysis., Results: In consideration of the variability of parents' specific desires, six predetermined topics and additional overarching themes such as perception of support, degree of understanding, hope, spirituality, and decision-making influences emerged. Studies suggest the quality of the antenatal consultation is not purely about information content, but also the manner in which it is provided. Limitations include thematic analysis that can potentially lead to the exclusion of important nuances. Relevant studies may have been missed if published outside the healthcare literature., Conclusions: The findings may inform clinical practice guidelines. This paper includes suggested strategies related to parents' perspectives that may facilitate communication during antenatal consultation for an extremely preterm infant. These strategies may also support parental engagement and satisfaction., (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Published
- 2018
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40. Emergency Physicians: Beware of the Consent Standard of Care.
- Author
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Moore GP, Matlock AG, Kiley JL, and Percy KD
- Abstract
Many emergency physicians view informed consent as a necessary component of treatments or procedures to be performed on their patients. When such procedures are necessary, often there is a discussion of risks, benefits and alternatives with forms signed to validate the discussion. Two Wisconsin emergency department medical-legal cases have expanded liability of the duty of informed consent. These cases have focused on withholding medication and diagnostic tests., Competing Interests: Conflicts of Interest: By the CPC-EM article submission agreement, all authors are required to disclose all affiliations, funding sources and financial or management relationships that could be perceived as potential sources of bias. The authors disclosed none. The opinions and assertions of the authors reflect their personal positons and do not reflect those of the US Army or government.
- Published
- 2018
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41. Worsening anemia associated with volvulus in a stable neonate with intestinal obstruction.
- Author
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Moore GP, Byrne A, Davila J, Sarfi E, and Bettolli M
- Subjects
- Adult, Anemia pathology, Cystic Fibrosis therapy, Digestive System Abnormalities complications, Digestive System Abnormalities surgery, Female, Genetic Testing, Humans, Infant, Newborn, Intestinal Obstruction surgery, Intestinal Volvulus complications, Intestinal Volvulus surgery, Laparotomy, Male, Pregnancy, Treatment Outcome, Anemia etiology, Cystic Fibrosis diagnosis, Digestive System Abnormalities diagnosis, Intestinal Obstruction etiology, Intestinal Volvulus diagnosis
- Abstract
Intrauterine intestinal obstruction complicated by midgut volvulus is a serious life-threatening diagnosis. Immediate surgical intervention is generally the course of action upon diagnosis to prevent morbidity and mortality. We report a case of intrauterine intestinal obstruction where the neonate then presented with an unusual onset of volvulus within the first 12 hours of life. The patient was born with generalized edema, a distended abdomen, and pallor. Unlike many cases, the patient did not present with typical signs of volvulus. Diagnostic imaging preceding delivery and the stable postnatal clinical course did not offer a justification for immediate laparotomy. Less than 24 hours later, the patient's hemoglobin significantly dropped leading to an emergent laparotomy. Findings included a volvulus of the terminal ileum and large amounts of intraluminal blood. Our case report includes an analysis of clinical observations that should be considered so that patients presenting with similar signs receive earlier surgical intervention.
- Published
- 2018
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42. Developing a Knowledge Test for a Neonatal Ethics Teaching Program.
- Author
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Moore GP, Ferretti E, and Daboval T
- Abstract
Objective The innovative Neonatal-Perinatal Medicine (NPM) Ethics Teaching Program at the University of Ottawa provides NPM trainees with vital foundational knowledge required to manage ethically contentious clinical scenarios frequently encountered in practice. In this study, our aim was to develop a knowledge test to assess the impact of the NPM Ethics Teaching Program on trainees' knowledge about ethics. Study design Using an iterative four-step process, we developed a test for assessing pre- and post-training knowledge of NPM ethics. We first created a blueprint of the test, identifying its purpose, length, and format. We then weighted the learning outcomes of the NPM Ethics Teaching Program sessions to determine the number of questions that would be asked to assess to each learning outcome. Next, we populated the question bank and constructed a draft test. We obtained feedback from content experts on the draft test and piloted the draft test with former trainees from the NPM Ethics Teaching Program. Results We developed a pre- and post-knowledge test in NPM ethics consisting of 44 multiple choice questions (MCQs), each with five response options. The test takes approximately 60 minutes to complete. It took roughly 15 months to design and pilot the NPM ethics test. Conclusions This test can aid in the assessment of the amount of NPM ethics gained by trainees and contribute to the identification of areas for improvement in teaching and in the overall ethics program. Further iterations of the test will allow for additional assessment of its validity and the efficacy of the teaching program. Given the lack of structured evaluative ethics teaching programs in NPM nationally, this project will act as another step towards the introduction of our NPM Ethics Teaching Program to other Canadian NPM residencies., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2017
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43. Effect of an Educational Presentation about Extremely Preterm Infants on Knowledge and Attitudes of Health Care Providers.
- Author
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Doucette S, Lemyre B, Daboval T, Dunn S, Akiki S, Barrowman N, and Moore GP
- Subjects
- Gestational Age, Humans, Infant, Newborn, Neonatal Nursing, Neonatology, Obstetric Nursing, Obstetrics, Pediatrics, Surveys and Questionnaires, Survival Rate, Attitude of Health Personnel, Education, Medical, Continuing, Education, Nursing, Continuing, Health Knowledge, Attitudes, Practice, Infant, Extremely Premature, Resuscitation
- Abstract
Objective To determine healthcare providers' knowledge (HCP) about survival rates of extremely preterm infants (EPI) and attitudes toward resuscitation before and after an educational presentation and, to examine the relationship between knowledge and attitudes toward resuscitation. Study Design Participants completed a survey before and after attending a presentation detailing evidence-based estimates of survival rates and surrounding ethical issues. Respondents included neonatologists, obstetricians, pediatricians, maternal-fetal medicine specialists, trainees in pediatrics, obstetrics, neonatal-perinatal medicine and neonatal and obstetrical nurses. Results In total, 166 participants attended an educational presentation and 130 participants completed both pre- and postsurveys (response rate 78%). Prepresentation, for all gestations, ≤ 50% of respondents correctly identified survival/intact survival rates. Postpresentation, correct responses regarding survival/intact survival rates ranged from 49 to 86% ( p < 0.001) and attitudes shifted toward being more likely to resuscitate at all gestations regardless of parental wishes. There was a weak-to-modest relationship (Spearman's coefficient 0.24-0.40, p < 0.001-0.004) between knowledge responses and attitudes. Conclusion Attendance at an educational presentation did improve HCP knowledge about survival and long term outcomes for EPI, but HCP still underestimated survival and were not always willing to resuscitate in accordance with parental wishes. These findings may represent barriers to some experts' recommendation to use shared decision-making with parents when considering the resuscitation options for their EPI., Competing Interests: Conflict of Interest: None., (Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.)
- Published
- 2017
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44. Field testing of decision coaching with a decision aid for parents facing extreme prematurity.
- Author
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Moore GP, Lemyre B, Daboval T, Ding S, Dunn S, Akiki S, Barrowman N, Shephard AL, and Lawson ML
- Subjects
- Adult, Canada, Female, Humans, Infant, Extremely Premature, Infant, Newborn, Male, Pregnancy, Surveys and Questionnaires, Decision Making, Decision Support Techniques, Mentoring methods, Parents
- Abstract
Objective: The objective of this study is to assess and modify an existing decision aid and field-test decision coaching with the modified aid during consultations with parents facing potential delivery at 23 to 24 weeks gestation., Study Design: International Patient Decision Aid Standards instrument (IPDASi) scoring deficits, multi-stakeholder group feedback and α-testing guided modifications. Feasibility/acceptability were assessed. The Decisional Conflict Scale was used to measure participants' decisional conflict before (T1) and immediately after (T2) the consultation., Results: IPDASi assessment of the existing aid (score 11/35) indicated it required updated data, more information and a palliative care description. Following modification, IPDASi score increased to 26/35. Twenty subjects (12 pregnancies) participated in field-testing; 15 completed all questionnaires. Most participants (89%) would definitely recommend this form of consultation. Decisional conflict scores decreased (P<0.001) between T1 (52±25) and T2 (10±16)., Conclusion: Field testing demonstrated that consultations using the aid with decision coaching were feasible, reduced decisional conflict and may facilitate shared decision-making.
- Published
- 2017
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45. Shared decision making for infants born at the threshold of viability: a prognosis-based guideline.
- Author
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Lemyre B, Daboval T, Dunn S, Kekewich M, Jones G, Wang D, Mason-Ward M, and Moore GP
- Subjects
- Canada, Gestational Age, Humans, Infant, Infant, Newborn, Practice Guidelines as Topic, Prognosis, Resuscitation methods, Tertiary Care Centers, Decision Making, Infant, Extremely Premature, Quality of Life, Resuscitation standards
- Abstract
Objective: Making prenatal decisions regarding resuscitation of extremely premature infants, based on gestational age alone is inadequate. We developed a prognosis-based guideline., Study Design: We followed a five step approach and used the AGREE II framework: (1) systematic review and critical appraisal of published guidelines; (2) identification of key medical factors for decision making; (3) systematic reviews; (4) creation of a multi-disciplinary working group and (5) external consultation and appraisal., Result: No published guideline met high-quality appraisal criteria. Survival, neurodevelopmental disability, quality of life of child and parents, and maternal mortality and risk of long-term morbidity were identified as key for quality decision-making. Eighteen stakeholders (including parents) advocated for the incorporation of parents' values and preferences in the process., Conclusion: A novel framework, based on prognosis, was generated to guide when early intensive and palliative care may both be offered to expectant parents. Pre-implementation assessment is underway to identify barriers and facilitators to putting in practice.
- Published
- 2016
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46. An innovative on-call system for paediatric residency programs: The alternate night float.
- Author
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Moore GP, Talarico S, Kempinska A, Lawrence SE, and Weisz DE
- Abstract
Background: Night-float systems, in which residents work consecutive nights, have been increasingly adopted in paediatric programs, but may be detrimental to residents' sleep and mood., Objective: To describe the self-reported impact of a novel system consisting of two consecutive weeks of 16 h overnight shifts every second day that was piloted at the Children's Hospital of Eastern Ontario (Ottawa, Ontario)., Methods: A survey of 28 senior paediatric residents examined their experience with the alternate night-float system in three domains (patient care, resident professional development and well-being) and their comparison of the system with the traditional overnight on-call system., Results: Twenty-six of 28 residents responded. Nearly all (96%) felt familiar with important details of inpatients and that handover was effective (92%). Results were mixed for professional development, with concerns about the quality of supervisors' feedback and perceived difficulty in attending daytime teaching. All residents believed that the night-float system provided a better learning experience compared with the traditional system. Less than 35% considered fatigue to be a notable problem, although 20% increased use of sleep aids or stimulants beyond their typical use. Ninety-six percent believed their workload was appropriate. All residents felt equally or less fatigued under the night-float system compared with the traditional system. Ninety-six percent recommended that the night-float model continue as the on-call system., Conclusions: This novel night-float system is an alternative method of providing paediatric inpatient night coverage because it meets duty hour regulations and has strong resident approval. Studies to examine its impact on residents and patient care in comparison with other systems are warranted.
- Published
- 2015
- Full Text
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47. Systematic Review and Quality Appraisal of International Guidelines on Perinatal Care of Extremely Premature Infants.
- Author
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Binepal N, Lemyre B, Dunn S, Daboval T, Aglipay M, Leduc S, and Moore GP
- Subjects
- Humans, Infant, Extremely Premature, Infant, Newborn, Evidence-Based Medicine standards, Practice Guidelines as Topic standards
- Abstract
Objectives: Clinicians often refer to published or local guidelines when counselling expectant parents on perinatal care decisions at the limits of viability. The objectives of this study are to systematically review the literature and assess the quality of published international guidelines regarding perinatal care of 22-25 week gestational age infants., Study Design: MEDLINE, Pre-MEDLINE and TRIP databases were systematically searched for guidelines on perinatal management of extremely premature infants. Included guidelines were: created by an institution that regularly cared for extremely premature infants; offered comprehensive care plans; and, published after 1999 in English. The final selected guidelines were appraised using the validated AGREE-II (Appraisal of Guidelines for Research & Evaluation) tool which consists of six quality domains (Scope and Purpose, Stakeholder Involvement, Rigour of Development, Clarity of Presentation, Applicability, and Editorial Independence). Overall guideline quality was rated and each appraiser was asked whether they recommended the guideline for use., Results: Electronic and grey searches yielded 263 publications. Screening left 37 guidelines, 16 of which met inclusion criteria. Appraisal revealed deficits within all quality domains, predominantly 'Applicability', 'Editorial Independence' and 'Rigour of Development'. A wide range of mean domain scores within each guideline was observed. Overall quality scores ranged from 11%-61%; no guideline was assessed as suitable for use without modifications., Conclusion: Based on the AGREE-II criteria, we identified deficits in the quality of all of the published international guidelines, highlighting the need for rigorously and transparently developed guidelines to inform practice related to perinatal care of 22-25 week gestational age infants.
- Published
- 2015
- Full Text
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48. Innovative holistic teaching in a Canadian Neonatal Perinatal Residency Program.
- Author
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Daboval T, Ferretti E, and Moore GP
- Subjects
- Canada, Communication, Decision Making, Educational Measurement, Holistic Health ethics, Humans, Neonatology ethics, Perinatology ethics, Ethics, Medical education, Holistic Health education, Internship and Residency organization & administration, Neonatology education, Perinatology education
- Published
- 2014
- Full Text
- View/download PDF
49. What emergency physicians should know about informed consent: legal scenarios, cases, and caveats.
- Author
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Moore GP, Moffett PM, Fider C, and Moore MJ
- Subjects
- Consent Forms history, Consent Forms legislation & jurisprudence, Consent Forms standards, Emergency Medicine ethics, Emergency Medicine legislation & jurisprudence, Emergency Medicine standards, History, 20th Century, History, 21st Century, Humans, Informed Consent ethics, Informed Consent legislation & jurisprudence, Informed Consent standards, Malpractice legislation & jurisprudence, United States, Emergency Medicine history, Informed Consent history, Malpractice history
- Abstract
The basic concept of obtaining informed consent is familiar to emergency physicians, and many consider themselves well versed on the topic; however, lack of obtaining proper informed consent is a frequent source of lawsuits. The legal definitions and nuances of informed consent might surprise even the most experienced physician. This article will detail the historical legal evolution of the concept of informed consent. It will also report defining and recent court cases that illustrate the current medical-legal status of informed consent. Special scenarios, caveats, and documentation recommendations are discussed. After reading this article the emergency physician will know how to practice and document the appropriate aspects of informed consent in emergency medicine, as well as understand available legal defenses if a lawsuit should arise., (© 2014 by the Society for Academic Emergency Medicine.)
- Published
- 2014
- Full Text
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50. Novel mutation in ABCA3 resulting in fatal congenital surfactant deficiency in two siblings.
- Author
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Moore GP, Lines MA, Geraghty MT, de Nanassy J, and Kovesi T
- Subjects
- Female, Genetic Markers, Humans, Infant, Infant, Newborn, Lung Diseases, Interstitial complications, Lung Diseases, Interstitial diagnosis, Lung Diseases, Interstitial genetics, Male, Siblings, ATP-Binding Cassette Transporters genetics, Mutation, Missense, Respiratory Distress Syndrome, Newborn etiology
- Published
- 2014
- Full Text
- View/download PDF
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