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10. Chronic Pain

Author

McQuay, Henry J., primary, Smith, Lesley A., additional, and Moore, R. Andrew, additional

Published
2018
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11. Pharmacological interventions for chronic pain in children: an overview of systematic reviews

Author

Eccleston, Christopher, Fisher, Emma, Cooper, Tess E., Grégoire, Marie-Claude, Heathcote, Lauren C., Krane, Elliot, Lord, Susan M., Sethna, Navil F., Anderson, Anna-Karenia, Anderson, Brian, Clinch, Jacqueline, Gray, Andrew L., Gold, Jeffrey I., Howard, Richard F., Ljungman, Gustaf, Moore, R. Andrew, Schechter, Neil, Wiffen, Philip J., Wilkinson, Nick M.R., Williams, David G., Wood, Chantal, van Tilburg, Miranda A.L., and Zernikow, Boris

Published
2019
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14. Reply to Monticone

Author

O'Connell, Neil Edward, primary, Moore, R. Andrew, additional, Stewart, Gavin, additional, Fisher, Emma, additional, Hearn, Leslie, additional, Eccleston, Christopher, additional, and Williams, Amanda C. de C., additional

Published
2023
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20. Dexketoprofen/tramadol: randomised double-blind trial and confirmation of empirical theory of combination analgesics in acute pain

Author

Moore, R. Andrew, Gay-Escoda, C., Figueiredo, R., Tóth-Bagi, Z., Dietrich, T., Milleri, S., Torres-Lagares, D., Hill, C. M., García-García, A., Coulthard, P., Wojtowicz, A., Matenko, D., Peñarrocha-Diago, M., Cuadripani, S., Pizà-Vallespir, B., Guerrero-Bayón, C., Bertolotti, M., Contini, M. P., Scartoni, S., Nizzardo, A., Capriati, A., and Maggi, C. A.

Published
2015
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26. Non-pharmacological interventions for fibromyalgia (fibromyalgia syndrome) in adults: an overview of Cochrane Reviews

Author

Häuser, Winfried, Fisher, Emma, Perrot, Serge, Moore, R Andrew, Makri, Souzi, and Bidonde, Julia

Subjects
Pharmacology (medical)
Abstract

This is a protocol for a Cochrane Review (overview). The objectives are as follows: To summarise the evidence on the effectiveness, acceptability, and safety of non‐pharmacological interventions for FMS in adults. To explore variability in methods across Cochrane Reviews, in regards to inclusion/exclusion criteria, outcomes, comparisons, and the methods of assessment of adverse events. To examine the quality of Cochrane Reviews of FMS and inform on how reporting of Cochrane Reviews on FMS may be improved.

Published
2022

31. Investigating the veracity of a sample of divergent published trial data in spinal pain.

Author

O'Connell, Neil E., Moore, R. Andrew, Stewart, Gavin, Fisher, Emma, Hearn, Leslie, Eccleston, Christopher, Williams, Amanda C de C, and de C Williams, Amanda C

Subjects
*PSYCHOTHERAPY, *BEHAVIOR therapy, *TRUST, *COGNITIVE therapy, *PAIN management
Abstract

Abstract: Evidence-based medicine is replete with studies assessing quality and bias, but few evaluating research integrity or trustworthiness. A recent Cochrane review of psychological interventions for chronic pain identified trials with a shared lead author with highly divergent results. We sought to systematically identify all similar trials from this author to explore their risk of bias, governance procedures, and trustworthiness.We searched OVID MEDLINE, EMBASE, CENTRAL and PEDro to 22/12/2021 for trials. We contacted the authors requesting details of trial registration, ethical approval, protocol, and access to the trial data for verification. We used the Cochrane Risk of Bias tool and the Cochrane Pregnancy and Childbirth group's Trustworthiness Screening Tool to guide systematic exploration of trustworthiness.Ten trials were included: nine compared cognitive behavioural therapy (CBT) and physical exercise to usual care, exercise alone, or physiotherapy, and one compared two brief CBT programmes. Eight trials reported results divergent from the evidence base. Assessment of risk of bias and participant characteristics identified no substantial concerns. Responses from the lead author did not satisfactorily explain this divergence. Trustworthiness screening identified concerns about research governance, data plausibility at baseline, the results, and apparent data duplication.We discuss the findings within the context of methods for establishing the trustworthiness of research findings generally. Important concerns regarding the trustworthiness of these trials reduce our confidence in them. They should probably not be used to inform the results and conclusions of systematic reviews, in clinical training, policy documents, or any relevant instruction regarding adult chronic pain management. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Pharmacotherapy for the Prevention of Chronic Pain after Surgery in Adults: An Updated Systematic Review and Meta-analysis

Author

Carley, Meg E., Chaparro, Luis E., Choiniere, Manon, Kehlet, Henrik, Moore, R. Andrew, Van den Kerkhof, Elizabeth, Gilron, Ian, Carley, Meg E., Chaparro, Luis E., Choiniere, Manon, Kehlet, Henrik, Moore, R. Andrew, Van den Kerkhof, Elizabeth, and Gilron, Ian

Abstract

Background Chronic postsurgical pain can severely impair patient health and quality of life. This systematic review update evaluated the effectiveness of systemic drugs to prevent chronic postsurgical pain. Methods The authors included double-blind, placebo-controlled, randomized controlled trials including adults that evaluated perioperative systemic drugs. Studies that evaluated same drug(s) administered similarly were pooled. The primary outcome was the proportion reporting any pain at 3 or more months postsurgery. Results The authors identified 70 new studies and 40 from 2013. Most evaluated ketamine, pregabalin, gabapentin, IV lidocaine, nonsteroidal anti-inflammatory drugs, and corticosteroids. Some meta-analyses showed statistically significant—but of unclear clinical relevance—reductions in chronic postsurgical pain prevalence after treatment with pregabalin, IV lidocaine, and nonsteroidal anti-inflammatory drugs. Meta-analyses with more than three studies and more than 500 participants showed no effect of ketamine on prevalence of any pain at 6 months when administered for 24 h or less (risk ratio, 0.62 [95% CI, 0.36 to 1.07]; prevalence, 0 to 88% ketamine; 0 to 94% placebo) or more than 24 h (risk ratio, 0.91 [95% CI, 0.74 to 1.12]; 6 to 71% ketamine; 5 to 78% placebo), no effect of pregabalin on prevalence of any pain at 3 months (risk ratio, 0.88 [95% CI, 0.70 to 1.10]; 4 to 88% pregabalin; 3 to 80% placebo) or 6 months (risk ratio, 0.78 [95% CI, 0.47 to 1.28]; 6 to 68% pregabalin; 4 to 69% placebo) when administered more than 24 h, and an effect of pregabalin on prevalence of moderate/severe pain at 3 months when administered more than 24 h (risk ratio, 0.47 [95% CI, 0.33 to 0.68]; 0 to 20% pregabalin; 4 to 34% placebo). However, the results should be interpreted with caution given small study sizes, variable surgical types, dosages, timing and method of outcome measurements in relation to the acute pain trajectory in quest

Published
2021

50. IASP Presidential Task Force on Cannabis and Cannabinoid Analgesia

Author

Haroutounian, Simon, primary, Arendt-Nielsen, Lars, additional, Belton, Joletta, additional, Blyth, Fiona M., additional, Degenhardt, Louisa, additional, Di Forti, Marta, additional, Eccleston, Christopher, additional, Finn, David P., additional, Finnerup, Nanna B, additional, Fisher, Emma, additional, Fogarty, Alexandra E., additional, Gilron, Ian, additional, Hohmann, Andrea G., additional, Kalso, Eija, additional, Krane, Elliot, additional, Mohiuddin, Mohammed, additional, Moore, R Andrew, additional, Rowbotham, Michael, additional, Soliman, Nadia, additional, Wallace, Mark, additional, Zinboonyahgoon, Nantthasorn, additional, and Rice, Andrew SC, additional

Published
2021
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