546 results on '"Moore, Malcolm J."'
Search Results
2. Supplementary Data 1 from Transverse Colon Primary Tumor Location as a Biomarker in Metastatic Colorectal Cancer: A Pooled Analysis of CCTG/AGITG CO.17 and CO.20 Randomized Clinical Trials
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Solar Vasconcelos, Joao Paulo, primary, Chen, Nan, primary, Titmuss, Emma, primary, Tu, Dongsheng, primary, Brule, Stephanie Y., primary, Goodwin, Rachel, primary, Jonker, Derek J., primary, Price, Timothy, primary, Zalcberg, John R., primary, Moore, Malcolm J., primary, Karapetis, Christos S., primary, Siu, Lillian, primary, Shapiro, Jeremy, primary, Simes, John, primary, Gill, Sharlene, primary, O'Callaghan, Chris J., primary, and Loree, Jonathan M., primary
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- 2024
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3. The association of health-care contact days with physical function and survival in CCTG/AGITG CO.17.
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Gupta, Arjun, O'Callaghan, Christopher J, Zhu, Liting, Jonker, Derek J, Wong, Ralph P W, Colwell, Bruce, Moore, Malcolm J, Karapetis, Christos S, Tebbutt, Niall C, Shapiro, Jeremy D, Tu, Dongsheng, and Booth, Christopher M
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PHYSICAL mobility ,CANCER patients ,OVERALL survival ,QUALITY of life ,SECONDARY analysis - Abstract
Introduction Although contact days—days with health-care contact outside home—are increasingly adopted as a measure of time toxicity and treatment burden, they could also serve as a surrogate of treatment-related harm. We sought to assess the association between contact days and patient-reported outcomes and the prognostic ability of contact days. Methods We conducted a secondary analysis of CO.17 that evaluated cetuximab vs supportive care in patients with advanced colorectal cancer. CO.17 collected European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 instrument data. We assessed the association between number of contact days in a window and changes in physical function and global health status and the association between number of contact days in the first 4 weeks with overall survival. Results There was a negative association between the number of contact days and change in physical function (per each additional contact day: at 4 weeks, 1.50-point decrease; 8 weeks, 1.06-point decrease; P < .0001 for both) but not with global health status. This negative association was seen in patients receiving cetuximab but not supportive care. More contact days in the first 4 weeks was associated with worse overall survival for all participants and patients receiving cetuximab (per each additional contact day: all participants, adjusted hazard ratio [HR] = 1.07, 95% confidence interval [CI] = 1.05 to 1.10; and cetuximab, adjusted HR = 1.08, 95% CI = 1.05 to 1.11; P < .0001 for both). Conclusions In this secondary analysis of a clinical trial, more contact days early in the course were associated with declines in physical function and worse survival in all participants and in participants receiving cancer-directed treatment. Trial registration ClinicalTrials.gov number, NCT00079066. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Characterizing the genomic landscape of locally advanced pancreatic cancer.
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Gonzalez Conchas, Galileo Arturo, primary, O'Kane, Grainne M., additional, Denroche, Robert Edward, additional, Jang, Gun Ho, additional, Fischer, Sandra, additional, Dodd, Anna, additional, Picardo, Sarah Louise, additional, Holter, Spring, additional, Wilson, Julie, additional, Zogopoulos, George, additional, Elimova, Elena, additional, Prince, Rebecca M., additional, Jang, Raymond Woo-Jun, additional, Moore, Malcolm J., additional, Biagi, James Joseph, additional, Notta, Faiyaz, additional, Grant, Robert C, additional, Gallinger, Steven, additional, Tsang, Erica S, additional, and Knox, Jennifer J., additional
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- 2024
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5. Transverse Colon Primary Tumor Location as a Biomarker in Metastatic Colorectal Cancer: A Pooled Analysis of CCTG/AGITG CO.17 and CO.20 Randomized Clinical Trials
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Solar Vasconcelos, Joao Paulo, primary, Chen, Nan, additional, Titmuss, Emma, additional, Tu, Dongsheng, additional, Brule, Stephanie Y., additional, Goodwin, Rachel, additional, Jonker, Derek J., additional, Price, Timothy, additional, Zalcberg, John R., additional, Moore, Malcolm J., additional, Karapetis, Christos S., additional, Siu, Lillian, additional, Shapiro, Jeremy, additional, Simes, John, additional, Gill, Sharlene, additional, O'Callaghan, Chris J., additional, and Loree, Jonathan M., additional
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- 2024
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6. Detection of Relapse by Low-dose Computed Tomography During Surveillance in Stage I Testicular Germ Cell Tumours
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Chung, Peter, O’Malley, Martin E., Jewett, Michael A.S., Bedard, Philippe L., Panzarella, Tony, Sturgeon, Jeremy, Moore, Malcolm J., Hamilton, Robert, Hansen, Aaron R., Anson-Cartwright, Lynn, Gospodarowicz, Mary, and Warde, Padraig
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- 2019
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7. Erlotinib Plus Gemcitabine Compared With Gemcitabine Alone in Patients With Advanced Pancreatic Cancer: A Phase III Trial of the National Cancer Institute of Canada Clinical Trials Group
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Moore, Malcolm J., primary, Goldstein, David, additional, Hamm, John, additional, Figer, Arie, additional, Hecht, Joel R., additional, Gallinger, Steven, additional, Au, Heather J., additional, Murawa, Pawel, additional, Walde, David, additional, Wolff, Robert A., additional, Campos, Daniel, additional, Lim, Robert, additional, Ding, Keyue, additional, Clark, Gary, additional, Voskoglou-Nomikos, Theodora, additional, Ptasynski, Mieke, additional, and Parulekar, Wendy, additional
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- 2023
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8. Impact of Granulocyte-colony Stimulating Factor on Bleomycin-induced Pneumonitis in Chemotherapy-treated Germ Cell Tumors
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Kwan, Edmond M., Beck, Sophie, Amir, Eitan, Jewett, Michael A., Sturgeon, Jeremy F., Anson-Cartwright, Lynn, Chung, Peter W., Warde, Padraig R., Moore, Malcolm J., Bedard, Philippe L., and Tran, Ben
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- 2018
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9. Phase II trial of veliparib in patients with previously treated BRCA-mutated pancreas ductal adenocarcinoma
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Lowery, Maeve A., Kelsen, David P., Capanu, Marinela, Smith, Sloane C., Lee, Jonathan W., Stadler, Zsofia K., Moore, Malcolm J., Kindler, Hedy L., Golan, Talia, Segal, Amiel, Maynard, Hannah, Hollywood, Ellen, Moynahan, MaryEllen, Salo-Mullen, Erin E., Do, Richard Kinh Gian, Chen, Alice P., Yu, Kenneth H., Tang, Laura H., and O'Reilly, Eileen M.
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- 2018
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10. Latency and interval therapy affect the evolution in metastatic colorectal cancer
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Nikbakht, Hamid, Jessa, Selin, Sukhai, Mahadeo A., Arseneault, Madeleine, Zhang, Tong, Letourneau, Louis, Thomas, Mariam, Bourgey, Mathieu, Roehrl, Michael H. A., Eveleigh, Robert, Chen, Eric X., Krzyzanowska, Monika, Moore, Malcolm J., Giesler, Amanda, Yu, Celeste, Bedard, Philippe L., Kamel-Reid, Suzanne, Majewski, Jacek, Siu, Lillian L., Riazalhosseini, Yasser, and Graham, Donna M.
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- 2020
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11. Vascular resection for pancreas cancer: Ten-year real-world experience from a single high-volume center.
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Henault, David, Kunde, Holden, Zatzman, Cody, Bevacqua, Daniela, Arshinoff, Danielle, Cleary, Sean P., Dawson, Laura A., Elimova, Elena, Grant, Robert C, Hosni, Ali, Jang, Raymond Woo-Jun, Knox, Jennifer J., McGilvray, Ian M., Mesci, Aruz, Moore, Malcolm J., Moulton, Carol-Anne, Reichman, Trevor, Shwaartz, Chaya, Tsang, Erica S, and Gallinger, Steven
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- 2024
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12. Figure S6 from Altered Gene Expression along the Glycolysis–Cholesterol Synthesis Axis Is Associated with Outcome in Pancreatic Cancer
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Karasinska, Joanna M., primary, Topham, James T., primary, Kalloger, Steve E., primary, Jang, Gun Ho, primary, Denroche, Robert E., primary, Culibrk, Luka, primary, Williamson, Laura M., primary, Wong, Hui-Li, primary, Lee, Michael K.C., primary, O'Kane, Grainne M., primary, Moore, Richard A., primary, Mungall, Andrew J., primary, Moore, Malcolm J., primary, Warren, Cassia, primary, Metcalfe, Andrew, primary, Notta, Faiyaz, primary, Knox, Jennifer J., primary, Gallinger, Steven, primary, Laskin, Janessa, primary, Marra, Marco A., primary, Jones, Steven J.M., primary, Renouf, Daniel J., primary, and Schaeffer, David F., primary
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- 2023
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13. Data from Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial
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Aung, Kyaw L., primary, Fischer, Sandra E., primary, Denroche, Robert E., primary, Jang, Gun-Ho, primary, Dodd, Anna, primary, Creighton, Sean, primary, Southwood, Bernadette, primary, Liang, Sheng-Ben, primary, Chadwick, Dianne, primary, Zhang, Amy, primary, O'Kane, Grainne M., primary, Albaba, Hamzeh, primary, Moura, Shari, primary, Grant, Robert C., primary, Miller, Jessica K., primary, Mbabaali, Faridah, primary, Pasternack, Danielle, primary, Lungu, Ilinca M., primary, Bartlett, John M.S., primary, Ghai, Sangeet, primary, Lemire, Mathieu, primary, Holter, Spring, primary, Connor, Ashton A., primary, Moffitt, Richard A., primary, Yeh, Jen Jen, primary, Timms, Lee, primary, Krzyzanowski, Paul M., primary, Dhani, Neesha, primary, Hedley, David, primary, Notta, Faiyaz, primary, Wilson, Julie M., primary, Moore, Malcolm J., primary, Gallinger, Steven, primary, and Knox, Jennifer J., primary
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- 2023
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14. Online Supplementary Materials from Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial
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Aung, Kyaw L., primary, Fischer, Sandra E., primary, Denroche, Robert E., primary, Jang, Gun-Ho, primary, Dodd, Anna, primary, Creighton, Sean, primary, Southwood, Bernadette, primary, Liang, Sheng-Ben, primary, Chadwick, Dianne, primary, Zhang, Amy, primary, O'Kane, Grainne M., primary, Albaba, Hamzeh, primary, Moura, Shari, primary, Grant, Robert C., primary, Miller, Jessica K., primary, Mbabaali, Faridah, primary, Pasternack, Danielle, primary, Lungu, Ilinca M., primary, Bartlett, John M.S., primary, Ghai, Sangeet, primary, Lemire, Mathieu, primary, Holter, Spring, primary, Connor, Ashton A., primary, Moffitt, Richard A., primary, Yeh, Jen Jen, primary, Timms, Lee, primary, Krzyzanowski, Paul M., primary, Dhani, Neesha, primary, Hedley, David, primary, Notta, Faiyaz, primary, Wilson, Julie M., primary, Moore, Malcolm J., primary, Gallinger, Steven, primary, and Knox, Jennifer J., primary
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- 2023
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15. Supplementary Table 1 from Phase II Clinical and Pharmacokinetic Study of Aflibercept in Patients with Previously Treated Metastatic Colorectal Cancer
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Tang, Patricia A., primary, Cohen, Steven J., primary, Kollmannsberger, Christian, primary, Bjarnason, Georg, primary, Virik, Kiran, primary, MacKenzie, Mary J., primary, Lourenco, Lillian, primary, Wang, Lisa, primary, Chen, Alice, primary, and Moore, Malcolm J., primary
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- 2023
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16. Evaluating the Time Toxicity of Cancer Treatment in the CCTG CO.17 Trial
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Gupta, Arjun, primary, O'Callaghan, Christopher J., additional, Zhu, Liting, additional, Jonker, Derek J., additional, Wong, Ralph P.W., additional, Colwell, Bruce, additional, Moore, Malcolm J., additional, Karapetis, Christos S., additional, Tebbutt, Niall C., additional, Shapiro, Jeremy D., additional, Tu, Dongsheng, additional, and Booth, Christopher M., additional
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- 2023
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17. Predictive and prognostic features of metastatic colorectal cancer arising from the transverse colon: A pooled analysis of the CCTG/AGITG CO.17 and CO.20 randomized trials.
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Solar Vasconcelos, Joao Paulo, primary, Chen, Nan, additional, Tu, Dongsheng, additional, Brule, Stephanie Yasmin, additional, Goodwin, Rachel Anne, additional, Jonker, Derek J., additional, Price, Timothy Jay, additional, Zalcberg, John Raymond, additional, Moore, Malcolm J., additional, Karapetis, Christos Stelios, additional, Siu, Lillian L., additional, Shapiro, Jeremy David, additional, Simes, John, additional, O'Callaghan, Christopher J., additional, and Loree, Jonathan M., additional
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- 2023
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18. A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
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Jiao, Wei, Atwal, Gurnit, Polak, Paz, Karlic, Rosa, Cuppen, Edwin, Al-Shahrour, Fatima, Bailey, Peter J, Biankin, Andrew V, Boutros, Paul C, Campbell, Peter J, Chang, David K, Cooke, Susanna L, Deshpande, Vikram, Faltas, Bishoy M, Faquin, William C, Garraway, Levi, Getz, Gad, Grimmond, Sean M, Haider, Syed, Hoadley, Katherine A, Kaiser, Vera B, Kato, Mamoru, Kübler, Kirsten, Lazar, Alexander J, Li, Constance H, Louis, David N, Margolin, Adam, Martin, Sancha, Nahal-Bose, Hardeep K, Nielsen, G Petur, Nik-Zainal, Serena, Omberg, Larsson, P’ng, Christine, Perry, Marc D, Rheinbay, Esther, Rubin, Mark A, Semple, Colin A, Sgroi, Dennis C, Shibata, Tatsuhiro, Siebert, Reiner, Smith, Jaclyn, Stein, Lincoln D, Stobbe, Miranda D, Sun, Ren X, Thai, Kevin, Wright, Derek W, Wu, Chin-Lee, Yuan, Ke, Zhang, Junjun, Danyi, Alexandra, de Ridder, Jeroen, van Herpen, Carla, Lolkema, Martijn P, Steeghs, Neeltje, Morris, Quaid D, Aaltonen, Lauri A, Abascal, Federico, Abeshouse, Adam, Aburatani, Hiroyuki, Adams, David J, Agrawal, Nishant, Ahn, Keun Soo, Ahn, Sung-Min, Aikata, Hiroshi, Akbani, Rehan, Akdemir, Kadir C, Al-Ahmadie, Hikmat, Al-Sedairy, Sultan T, Alawi, Malik, Albert, Monique, Aldape, Kenneth, Alexandrov, Ludmil B, Ally, Adrian, Alsop, Kathryn, Alvarez, Eva G, Amary, Fernanda, Amin, Samirkumar B, Aminou, Brice, Ammerpohl, Ole, Anderson, Matthew J, Ang, Yeng, Antonello, Davide, Anur, Pavana, Aparicio, Samuel, Appelbaum, Elizabeth L, Arai, Yasuhito, Aretz, Axel, Arihiro, Koji, Ariizumi, Shun-ichi, Armenia, Joshua, Arnould, Laurent, Asa, Sylvia, Assenov, Yassen, Aukema, Sietse, Auman, J Todd, Aure, Miriam RR, Awadalla, Philip, Aymerich, Marta, Bader, Gary D, Baez-Ortega, Adrian, Bailey, Matthew H, Balasundaram, Miruna, Balu, Saianand, Bandopadhayay, Pratiti, Banks, Rosamonde E, Barbi, Stefano, Barbour, Andrew P, Barenboim, Jonathan, Barnholtz-Sloan, Jill, Barr, Hugh, Barrera, Elisabet, Bartlett, John, Bartolome, Javier, Bassi, Claudio, Bathe, Oliver F, Baumhoer, Daniel, Bavi, Prashant, Baylin, Stephen B, Bazant, Wojciech, Beardsmore, Duncan, Beck, Timothy A, Behjati, Sam, Behren, Andreas, Niu, Beifang, Bell, Cindy, Beltran, Sergi, Benz, Christopher, Berchuck, Andrew, Bergmann, Anke K, Bergstrom, Erik N, Berman, Benjamin P, Berney, Daniel M, Bernhart, Stephan H, Beroukhim, Rameen, Berrios, Mario, Bersani, Samantha, Bertl, Johanna, Betancourt, Miguel, Bhandari, Vinayak, Bhosle, Shriram G, Bieg, Matthias, Bigner, Darell, Binder, Hans, Birney, Ewan, Birrer, Michael, Biswas, Nidhan K, Bjerkehagen, Bodil, Bodenheimer, Tom, Boice, Lori, Bonizzato, Giada, De Bono, Johann S, Boot, Arnoud, Bootwalla, Moiz S, Borg, Ake, Borkhardt, Arndt, Boroevich, Keith A, Borozan, Ivan, Borst, Christoph, Bosenberg, Marcus, Bosio, Mattia, Boultwood, Jacqueline, Bourque, Guillaume, Bova, G Steven, Bowen, David T, Bowlby, Reanne, Bowtell, David DL, Boyault, Sandrine, Boyce, Rich, Boyd, Jeffrey, Brazma, Alvis, Brennan, Paul, Brewer, Daniel S, Brinkman, Arie B, Bristow, Robert G, Broaddus, Russell R, Brock, Jane E, Brock, Malcolm, Broeks, Annegien, Brooks, Angela N, Brooks, Denise, Brors, Benedikt, Brunak, Søren, Bruxner, Timothy JC, Bruzos, Alicia L, Buchanan, Alex, Buchhalter, Ivo, Buchholz, Christiane, Bullman, Susan, Burke, Hazel, Burkhardt, Birgit, Burns, Kathleen H, Busanovich, John, Bustamante, Carlos D, Butler, Adam P, Butte, Atul J, Byrne, Niall J, Børresen-Dale, Anne-Lise, Caesar-Johnson, Samantha J, Cafferkey, Andy, Cahill, Declan, Calabrese, Claudia, Caldas, Carlos, Calvo, Fabien, Camacho, Niedzica, Campo, Elias, Cantù, Cinzia, Cao, Shaolong, Carey, Thomas E, Carlevaro-Fita, Joana, Carlsen, Rebecca, Cataldo, Ivana, Cazzola, Mario, Cebon, Jonathan, Cerfolio, Robert, Chadwick, Dianne E, Chakravarty, Dimple, Chalmers, Don, Chan, Calvin Wing Yiu, Chan, Kin, Chan-Seng-Yue, Michelle, Chandan, Vishal S, Chanock, Stephen J, Chantrill, Lorraine A, Chateigner, Aurélien, Chatterjee, Nilanjan, Chayama, Kazuaki, Chen, Hsiao-Wei, Chen, Jieming, Chen, Ken, Chen, Yiwen, Chen, Zhaohong, Cherniack, Andrew D, Chien, Jeremy, Chiew, Yoke-Eng, Chin, Suet-Feung, Cho, Juok, Cho, Sunghoon, Choi, Jung Kyoon, Choi, Wan, Chomienne, Christine, Chong, Zechen, Choo, Su Pin, Chou, Angela, Christ, Angelika N, Christie, Elizabeth L, Chuah, Eric, Cibulskis, Carrie, Cibulskis, Kristian, Cingarlini, Sara, Clapham, Peter, Claviez, Alexander, Cleary, Sean, Cloonan, Nicole, Cmero, Marek, Collins, Colin C, Connor, Ashton A, Cooper, Colin S, Cope, Leslie, Corbo, Vincenzo, Cordes, Matthew G, Cordner, Stephen M, Cortés-Ciriano, Isidro, Covington, Kyle, Cowin, Prue A, Craft, Brian, Craft, David, Creighton, Chad J, Cun, Yupeng, Curley, Erin, Cutcutache, Ioana, Czajka, Karolina, Czerniak, Bogdan, Dagg, Rebecca A, Danilova, Ludmila, Davi, Maria Vittoria, Davidson, Natalie R, Davies, Helen, Davis, Ian J, Davis-Dusenbery, Brandi N, Dawson, Kevin J, De La Vega, Francisco M, De Paoli-Iseppi, Ricardo, Defreitas, Timothy, Dei Tos, Angelo P, Delaneau, Olivier, Demchok, John A, Demeulemeester, Jonas, Demidov, German M, Demircioğlu, Deniz, Dennis, Nening M, Denroche, Robert E, Dentro, Stefan C, Desai, Nikita, Deshwar, Amit G, Desmedt, Christine, Deu-Pons, Jordi, Dhalla, Noreen, Dhani, Neesha C, Dhingra, Priyanka, Dhir, Rajiv, DiBiase, Anthony, Diamanti, Klev, Ding, Li, Ding, Shuai, Dinh, Huy Q, Dirix, Luc, Doddapaneni, HarshaVardhan, Donmez, Nilgun, Dow, Michelle T, Drapkin, Ronny, Drechsel, Oliver, Drews, Ruben M, Serge, Serge, Dudderidge, Tim, Dueso-Barroso, Ana, Dunford, Andrew J, Dunn, Michael, Dursi, Lewis Jonathan, Duthie, Fraser R, Dutton-Regester, Ken, Eagles, Jenna, Easton, Douglas F, Edmonds, Stuart, Edwards, Paul A, Edwards, Sandra E, Eeles, Rosalind A, Ehinger, Anna, Eils, Juergen, Eils, Roland, El-Naggar, Adel, Eldridge, Matthew, Ellrott, Kyle, Erkek, Serap, Escaramis, Georgia, Espiritu, Shadrielle MG, Estivill, Xavier, Etemadmoghadam, Dariush, Eyfjord, Jorunn E, Fan, Daiming, Fan, Yu, Farcas, Claudiu, Fassan, Matteo, Fatima, Aquila, Favero, Francesco, Fayzullaev, Nodirjon, Felau, Ina, Fereday, Sian, Ferguson, Martin L, Ferretti, Vincent, Feuerbach, Lars, Field, Matthew A, Fink, J Lynn, Finocchiaro, Gaetano, Fisher, Cyril, Fittall, Matthew W, Fitzgerald, Anna, Fitzgerald, Rebecca C, Flanagan, Adrienne M, Fleshner, Neil E, Flicek, Paul, Foekens, John A, Fong, Kwun M, Fonseca, Nuno A, Foster, Christopher S, Fox, Natalie S, Fraser, Michael, Frazer, Scott, Frenkel-Morgenstern, Milana, Friedman, William, Frigola, Joan, Fronick, Catrina C, Fujimoto, Akihiro, Fujita, Masashi, Fukayama, Masashi, Fulton, Lucinda A, Fulton, Robert S, Furuta, Mayuko, Futreal, P Andrew, Füllgrabe, Anja, Gabriel, Stacey B, Gallinger, Steven, Gambacorti-Passerini, Carlo, Gao, Jianjiong, Gao, Shengjie, Garred, Øystein, Garrison, Erik, Garsed, Dale W, Gehlenborg, Nils, Gelpi, Josep LL, George, Joshy, Gerhard, Daniela S, Gerhauser, Clarissa, Gershenwald, Jeffrey E, Gerstein, Mark, Gerstung, Moritz, Ghori, Mohammed, Ghossein, Ronald, Giama, Nasra H, Gibbs, Richard A, Gibson, Bob, Gill, Anthony J, Gill, Pelvender, Giri, Dilip D, Glodzik, Dominik, Gnanapragasam, Vincent J, Goebler, Maria Elisabeth, Goldman, Mary J, Gomez, Carmen, Gonzalez, Santiago, Gonzalez-Perez, Abel, Gordenin, Dmitry A, Gossage, James, Gotoh, Kunihito, Govindan, Ramaswamy, Grabau, Dorthe, Graham, Janet S, Grant, Robert C, Green, Anthony R, Green, Eric, Greger, Liliana, Grehan, Nicola, Grimaldi, Sonia, Grossman, Robert L, Grundhoff, Adam, Gundem, Gunes, Guo, Qianyun, Gupta, Manaswi, Gupta, Shailja, Gut, Ivo G, Gut, Marta, Göke, Jonathan, Ha, Gavin, Haake, Andrea, Haan, David, Haas, Siegfried, Haase, Kerstin, Haber, James E, Habermann, Nina, Hach, Faraz, Hama, Natsuko, Hamdy, Freddie C, Hamilton, Anne, Hamilton, Mark P, Han, Leng, Hanna, George B, Hansmann, Martin, Haradhvala, Nicholas J, Harismendy, Olivier, Harliwong, Ivon, Harmanci, Arif O, Harrington, Eoghan, Hasegawa, Takanori, Haussler, David, Hawkins, Steve, Hayami, Shinya, Hayashi, Shuto, Hayes, D Neil, Hayes, Stephen J, Hayward, Nicholas K, Hazell, Steven, He, Yao, Heath, Allison P, Heath, Simon C, Hedley, David, Hegde, Apurva M, Heiman, David I, Heinold, Michael C, Heins, Zachary, Heisler, Lawrence E, Hellstrom-Lindberg, Eva, Helmy, Mohamed, Heo, Seong Gu, Hepperla, Austin J, Heredia-Genestar, José María, Herrmann, Carl, Hersey, Peter, Hess, Julian M, Hilmarsdottir, Holmfridur, Hinton, Jonathan, Hirano, Satoshi, Hiraoka, Nobuyoshi, Hobolth, Asger, Hodzic, Ermin, Hoell, Jessica I, Hoffmann, Steve, Hofmann, Oliver, Holbrook, Andrea, Holik, Aliaksei Z, Hollingsworth, Michael A, Holmes, Oliver, Holt, Robert A, Hong, Chen, Hong, Eun Pyo, Hong, Jongwhi H, Hooijer, Gerrit K, Hornshøj, Henrik, Hosoda, Fumie, Hou, Yong, Hovestadt, Volker, Howat, William, Hoyle, Alan P, Hruban, Ralph H, Hu, Jianhong, Hu, Taobo, Hua, Xing, Huang, Kuan-lin, Huang, Mei, Huang, Mi Ni, Huang, Vincent, Huang, Yi, Huber, Wolfgang, Hudson, Thomas J, Hummel, Michael, Hung, Jillian A, Huntsman, David, Hupp, Ted R, Huse, Jason, Huska, Matthew R, Hutter, Barbara, Hutter, Carolyn M, Hübschmann, Daniel, Iacobuzio-Donahue, Christine A, Imbusch, Charles David, Imielinski, Marcin, Imoto, Seiya, Isaacs, William B, Isaev, Keren, Ishikawa, Shumpei, Iskar, Murat, Islam, SM Ashiqul, Ittmann, Michael, Ivkovic, Sinisa, Izarzugaza, Jose MG, Jacquemier, Jocelyne, Jakrot, Valerie, Jamieson, Nigel B, Jang, Gun Ho, Jang, Se Jin, Jayaseelan, Joy C, Jayasinghe, Reyka, Jefferys, Stuart R, Jegalian, Karine, Jennings, Jennifer L, Jeon, Seung-Hyup, Jerman, Lara, Ji, Yuan, Johansson, Peter A, Johns, Amber L, Johns, Jeremy, Johnson, Rory, Johnson, Todd A, Jolly, Clemency, Joly, Yann, Jonasson, Jon G, Jones, Corbin D, Jones, David R, Jones, David TW, Jones, Nic, Jones, Steven JM, Jonkers, Jos, Ju, Young Seok, Juhl, Hartmut, Jung, Jongsun, Juul, Malene, Juul, Randi Istrup, Juul, Sissel, Jäger, Natalie, Kabbe, Rolf, Kahles, Andre, Kahraman, Abdullah, Kakavand, Hojabr, Kalimuthu, Sangeetha, von Kalle, Christof, Kang, Koo Jeong, Karaszi, Katalin, Karlan, Beth, Karlić, Rosa, Karsch, Dennis, Kasaian, Katayoon, Kassahn, Karin S, Katai, Hitoshi, Katoh, Hiroto, Kawakami, Yoshiiku, Kay, Jonathan D, Kazakoff, Stephen H, Kazanov, Marat D, Keays, Maria, Kebebew, Electron, Kefford, Richard F, Kellis, Manolis, Kench, James G, Kennedy, Catherine J, Kerssemakers, Jules NA, Khoo, David, Khoo, Vincent, Khuntikeo, Narong, Khurana, Ekta, Kilpinen, Helena, Kim, Hark Kyun, Kim, Hyung-Lae, Kim, Hyung-Yong, Kim, Hyunghwan, Kim, Jaegil, Kim, Jihoon, Kim, Jong K, Kim, Youngwook, King, Tari A, Klapper, Wolfram, Kleinheinz, Kortine, Klimczak, Leszek J, Knappskog, Stian, Kneba, Michael, Knoppers, Bartha M, Koh, Youngil, Komorowski, Jan, Komura, Daisuke, Komura, Mitsuhiro, Kong, Gu, Kool, Marcel, Korbel, Jan O, Korchina, Viktoriya, Korshunov, Andrey, Koscher, Michael, Koster, Roelof, Kote-Jarai, Zsofia, Koures, Antonios, Kovacevic, Milena, Kremeyer, Barbara, Kretzmer, Helene, Kreuz, Markus, Krishnamurthy, Savitri, Kube, Dieter, Kumar, 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Deurzen, Carolien HM, van de Vijver, Marc J, Veer, L van’t, and von Mering, Christian
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
In cancer, the primary tumour’s organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we train a deep learning classifier to predict cancer type based on patterns of somatic passenger mutations detected in whole genome sequencing (WGS) of 2606 tumours representing 24 common cancer types produced by the PCAWG Consortium. Our classifier achieves an accuracy of 91% on held-out tumor samples and 88% and 83% respectively on independent primary and metastatic samples, roughly double the accuracy of trained pathologists when presented with a metastatic tumour without knowledge of the primary. Surprisingly, adding information on driver mutations reduced accuracy. Our results have clinical applicability, underscore how patterns of somatic passenger mutations encode the state of the cell of origin, and can inform future strategies to detect the source of circulating tumour DNA.
- Published
- 2023
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19. Combined burden and functional impact tests for cancer driver discovery using DriverPower
- Author
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
The discovery of driver mutations is one of the key motivations for cancer genome sequencing. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we describe DriverPower, a software package that uses mutational burden and functional impact evidence to identify driver mutations in coding and non-coding sites within cancer whole genomes. Using a total of 1373 genomic features derived from public sources, DriverPower’s background mutation model explains up to 93% of the regional variance in the mutation rate across multiple tumour types. By incorporating functional impact scores, we are able to further increase the accuracy of driver discovery. Testing across a collection of 2583 cancer genomes from the PCAWG project, DriverPower identifies 217 coding and 95 non-coding driver candidates. Comparing to six published methods used by the PCAWG Drivers and Functional Interpretation Working Group, DriverPower has the highest F1 score for both coding and non-coding driver discovery. This demonstrates that DriverPower is an effective framework for computational driver discovery.
- Published
- 2023
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20. Integrative pathway enrichment analysis of multivariate omics data
- Author
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Paczkowska, Marta, Barenboim, Jonathan, Sintupisut, Nardnisa, Fox, Natalie S, Zhu, Helen, Abd-Rabbo, Diala, Mee, Miles W, Boutros, Paul C, Abascal, Federico, Amin, Samirkumar B, Bader, Gary D, Beroukhim, Rameen, Bertl, Johanna, Boroevich, Keith A, Brunak, Søren, Campbell, Peter J, Carlevaro-Fita, Joana, Chakravarty, Dimple, Chan, Calvin Wing Yiu, Chen, Ken, Choi, Jung Kyoon, Deu-Pons, Jordi, Dhingra, Priyanka, Diamanti, Klev, Feuerbach, Lars, Fink, J Lynn, Fonseca, Nuno A, Frigola, Joan, Gambacorti-Passerini, Carlo, Garsed, Dale W, Gerstein, Mark, Getz, Gad, Gonzalez-Perez, Abel, Guo, Qianyun, Gut, Ivo G, Haan, David, Hamilton, Mark P, Haradhvala, Nicholas J, Harmanci, Arif O, Helmy, Mohamed, Herrmann, Carl, Hess, Julian M, Hobolth, Asger, Hodzic, Ermin, Hong, Chen, Hornshøj, Henrik, Isaev, Keren, Izarzugaza, Jose MG, Johnson, Rory, Johnson, Todd A, Juul, Malene, Juul, Randi Istrup, Kahles, Andre, Kahraman, Abdullah, Kellis, Manolis, Khurana, Ekta, Kim, Jaegil, Kim, Jong K, Kim, 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Vijver, Marc J, and Veer, L van’t
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
Multi-omics datasets represent distinct aspects of the central dogma of molecular biology. Such high-dimensional molecular profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an integrative method that discovers significantly enriched pathways across multiple datasets using statistical data fusion, rationalizes contributing evidence and highlights associated genes. As part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumor types, we integrated genes with coding and non-coding mutations and revealed frequently mutated pathways and additional cancer genes with infrequent mutations. We also analyzed prognostic molecular pathways by integrating genomic and transcriptomic features of 1780 breast cancers and highlighted associations with immune response and anti-apoptotic signaling. Integration of ChIP-seq and RNA-seq data for master regulators of the Hippo pathway across normal human tissues identified processes of tissue regeneration and stem cell regulation. ActivePathways is a versatile method that improves systems-level understanding of cellular organization in health and disease through integration of multiple molecular datasets and pathway annotations.
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- 2023
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21. Pathway and network analysis of more than 2500 whole cancer genomes
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
The catalog of cancer driver mutations in protein-coding genes has greatly expanded in the past decade. However, non-coding cancer driver mutations are less well-characterized and only a handful of recurrent non-coding mutations, most notably TERT promoter mutations, have been reported. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancer across 38 tumor types, we perform multi-faceted pathway and network analyses of non-coding mutations across 2583 whole cancer genomes from 27 tumor types compiled by the ICGC/TCGA PCAWG project that was motivated by the success of pathway and network analyses in prioritizing rare mutations in protein-coding genes. While few non-coding genomic elements are recurrently mutated in this cohort, we identify 93 genes harboring non-coding mutations that cluster into several modules of interacting proteins. Among these are promoter mutations associated with reduced mRNA expression in TP53, TLE4, and TCF4. We find that biological processes had variable proportions of coding and non-coding mutations, with chromatin remodeling and proliferation pathways altered primarily by coding mutations, while developmental pathways, including Wnt and Notch, altered by both coding and non-coding mutations. RNA splicing is primarily altered by non-coding mutations in this cohort, and samples containing non-coding mutations in well-known RNA splicing factors exhibit similar gene expression signatures as samples with coding mutations in these genes. These analyses contribute a new repertoire of possible cancer genes and mechanisms that are altered by non-coding mutations and offer insights into additional cancer vulnerabilities that can be investigated for potential therapeutic treatments.
- Published
- 2023
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22. Divergent mutational processes distinguish hypoxic and normoxic tumours
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific mutational processes, non-coding driver genes and evolutionary features. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we quantify hypoxia in 1188 tumours spanning 27 cancer types. Elevated hypoxia associates with increased mutational load across cancer types, irrespective of underlying mutational class. The proportion of mutations attributed to several mutational signatures of unknown aetiology directly associates with the level of hypoxia, suggesting underlying mutational processes for these signatures. At the gene level, driver mutations in TP53, MYC and PTEN are enriched in hypoxic tumours, and mutations in PTEN interact with hypoxia to direct tumour evolutionary trajectories. Overall, hypoxia plays a critical role in shaping the genomic and evolutionary landscapes of cancer.
- Published
- 2023
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23. Genomic footprints of activated telomere maintenance mechanisms in cancer
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Christian
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we dissect whole-genome sequencing data of over 2500 matched tumor-control samples from 36 different tumor types aggregated within the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium to characterize the genomic footprints of these mechanisms. While the telomere content of tumors with ATRX or DAXX mutations (ATRX/DAXXtrunc) is increased, tumors with TERT modifications show a moderate decrease of telomere content. One quarter of all tumor samples contain somatic integrations of telomeric sequences into non-telomeric DNA. This fraction is increased to 80% prevalence in ATRX/DAXXtrunc tumors, which carry an aberrant telomere variant repeat (TVR) distribution as another genomic marker. The latter feature includes enrichment or depletion of the previously undescribed singleton TVRs TTCGGG and TTTGGG, respectively. Our systematic analysis provides new insight into the recurrent genomic alterations associated with telomere maintenance mechanisms in cancer.
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- 2023
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24. Evaluating the time toxicity of cancer treatment in the CCTG CO.17 randomized clinical trial (RCT).
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Gupta, Arjun, primary, O'Callaghan, Christopher J., additional, Zhu, Liting, additional, Jonker, Derek J., additional, Wong, Ralph, additional, Colwell, Bruce, additional, Moore, Malcolm J, additional, Karapetis, Christos Stelios, additional, Tebbutt, Niall C, additional, Shapiro, Jeremy David, additional, Tu, Dongsheng, additional, and Booth, Christopher M., additional
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- 2022
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25. Prospective Evaluation of Acute Toxicity and Quality of Life After IMRT and Concurrent Chemotherapy for Anal Canal and Perianal Cancer
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Han, Kathy, Cummings, Bernard J., Lindsay, Patricia, Skliarenko, Julia, Craig, Tim, Le, Lisa W., Brierley, James, Wong, Rebecca, Dinniwell, Robert, Bayley, Andrew J., Dawson, Laura A., Ringash, Jolie, Krzyzanowska, Monika K., Moore, Malcolm J., Chen, Eric X., Easson, Alexandra M., Kassam, Zahra, Cho, Charles, and Kim, John
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- 2014
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26. Chemotherapy in Prostate Cancer
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Sridhar, Srikala S., Moore, Malcolm J., and Waxman, Jonathan, editor
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- 2007
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27. Survival Following Resection of Intra- and Extra-Hepatic Metastases from Colorectal Cancer: A Phase II Trial
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Wei, Alice C., Coburn, Natalie G., Devitt, Katharine S., Serrano, Pablo E., Moulton, Carol-Anne, Cleary, Sean P., Law, Calvin, Moore, Malcolm J., and Gallinger, Steven
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- 2016
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28. Chemotherapy in Prostate Cancer
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Sridhar, Srikala S., Moore, Malcolm J., and Waxman, Jonathan, editor
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- 2005
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29. Pancreatic Adenocarcinoma Surveillance Counterpoint: Canada
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Moore, Malcolm J., Stathis, Anastasios, Johnson, Frank E., editor, Maehara, Yoshihiko, editor, Browman, George P., editor, Margenthaler, Julie A., editor, Audisio, Riccardo A., editor, Thompson, John F., editor, Johnson, David Y., editor, Earle, Craig C., editor, and Virgo, Katherine S., editor
- Published
- 2013
- Full Text
- View/download PDF
30. Pooled Analysis of Phase II Trials Evaluating Weekly or Conventional Cisplatin as First-Line Therapy for Advanced Urothelial Carcinoma
- Author
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Maughan, Benjamin L., Agarwal, Neeraj, Hussain, Syed A., Boucher, Kenneth M., Von Der Maase, Hans, Kaufman, Donald S., Lorusso, Vito, Moore, Malcolm J., Galsky, Matthew D., and Sonpavde, Guru
- Published
- 2013
- Full Text
- View/download PDF
31. Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): a phase 3 randomised controlled trial
- Author
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de Gramont, Aimery, Van Cutsem, Eric, Schmoll, Hans-Joachim, Tabernero, Josep, Clarke, Stephen, Moore, Malcolm J, Cunningham, David, Cartwright, Thomas H, Hecht, J Randolph, Rivera, Fernando, Im, Seock-Ah, Bodoky, György, Salazar, Ramon, Maindrault-Goebel, Frédérique, Shacham-Shmueli, Einat, Bajetta, Emilio, Makrutzki, Martina, Shang, Aijing, André, Thierry, and Hoff, Paulo M
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- 2012
- Full Text
- View/download PDF
32. Nitrogen Mustards
- Author
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Goldenberg, Gerald J., Moore, Malcolm J., and Teicher, Beverly A., editor
- Published
- 1997
- Full Text
- View/download PDF
33. A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575)
- Author
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Richter, Suzanne, Bedard, Philippe L., Chen, Eric Xueyu, Clarke, Blaise A., Tran, Ben, Hotte, Sebastien J., Stathis, Anastasios, Hirte, Hal W., Razak, Albiruni R. A., Reedijk, Michael, Chen, Zhuo, Cohen, Brenda, Zhang, Wen-Jiang, Wang, Lisa, Ivy, S. Percy, Moore, Malcolm J., Oza, Amit M., Siu, Lillian L., and McWhirter, Elaine
- Published
- 2014
- Full Text
- View/download PDF
34. Treatment of metastatic bladder cancer in the elderly
- Author
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Moore, Malcolm J., Oreopoulos, Dimitrios G., editor, Michelis, Michael F., editor, and Herschorn, Sender, editor
- Published
- 1993
- Full Text
- View/download PDF
35. Pancreatic Cancer hENT1 Expression and Survival From Gemcitabine in Patients From the ESPAC-3 Trial
- Author
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Greenhalf, William, Ghaneh, Paula, Neoptolemos, John P., Palmer, Daniel H., Cox, Trevor F., Lamb, Richard F., Garner, Elizabeth, Campbell, Fiona, Mackey, John R., Costello, Eithne, Moore, Malcolm J., Valle, Juan W., McDonald, Alexander C., Carter, Ross, Tebbutt, Niall C., Goldstein, David, Shannon, Jennifer, Dervenis, Christos, Glimelius, Bengt, Deakin, Mark, Charnley, Richard M., Lacaine, François, Scarfe, Andrew G., Middleton, Mark R., Anthoney, Alan, Halloran, Christopher M., Mayerle, Julia, Oláh, Attila, Jackson, Richard, Rawcliffe, Charlotte L., Scarpa, Aldo, Bassi, Claudio, and Büchler, Markus W.
- Published
- 2014
- Full Text
- View/download PDF
36. A Phase I/II Study of GTI-2040 Plus Docetaxel as Second-Line Treatment in Advanced Non-small Cell Lung Cancer: A Study of the PMH Phase II Consortium
- Author
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Leighl, Natasha B., Laurie, Scott A., Chen, Xueyu E., Ellis, Peter, Shepherd, Frances A., Knox, Jennifer J., Goss, Glenwood, Burkes, Ronald L., Pond, Gregory R., Dick, Christopher, Yen, Yun, Zwiebel, James A., and Moore, Malcolm J.
- Published
- 2009
- Full Text
- View/download PDF
37. A phase II study of cediranib (AZD 2171) in treatment naive patients with progressive unresectable recurrent or metastatic renal cell carcinoma. A trial of the PMH phase 2 consortium
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Sridhar, Srikala S., Mackenzie, Mary J., Hotte, Sebastien J., Mukherjee, Som D., Tannock, Ian F., Murray, Nevin, Kollmannsberger, Christian, Haider, Masoom A., Chen, Eric X., Halford, Robert, Wang, Lisa, Ivy, S. Percy, and Moore, Malcolm J.
- Published
- 2013
- Full Text
- View/download PDF
38. Phase I study of axitinib (AG-013736) in combination with gemcitabine in patients with advanced pancreatic cancer
- Author
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Spano, Jean-Philippe, Moore, Malcolm J., Pithavala, Yazdi K., Ricart, Alejandro D., Kim, Sinil, and Rixe, Olivier
- Published
- 2012
- Full Text
- View/download PDF
39. A phase II study of the halichondrin B analog eribulin mesylate in gemcitabine refractory advanced pancreatic cancer
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Renouf, Daniel J., Tang, Patricia A., Major, Pierre, Krzyzanowska, Monika K., Dhesy-Thind, Bindi, Goffin, John R., Hedley, David, Wang, Lisa, Doyle, L., and Moore, Malcolm J.
- Published
- 2012
- Full Text
- View/download PDF
40. A phase II study of capecitabine, irinotecan, and bevacizumab in patients with previously untreated metastatic colorectal cancer
- Author
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Renouf, Daniel J., Welch, Stephen, Moore, Malcolm J., Krzyzanowska, Monika K., Knox, Jennifer, Feld, Ronald, Liu, Geoffrey, MacKay, Helen, Petronis, Jennifer, Wang, Lisa, and Chen, Eric
- Published
- 2012
- Full Text
- View/download PDF
41. A phase I/II study of the Src inhibitor saracatinib (AZD0530) in combination with gemcitabine in advanced pancreatic cancer
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Renouf, Daniel J., Moore, Malcolm J., Hedley, David, Gill, Sharlene, Jonker, Derek, Chen, Eric, Walde, David, Goel, Rakesh, Southwood, Bernadette, Gauthier, Isabelle, Walsh, Wendy, McIntosh, Lynn, and Seymour, Lesley
- Published
- 2012
- Full Text
- View/download PDF
42. A phase II trial of sorafenib in first-line metastatic urothelial cancer: a study of the PMH Phase II Consortium
- Author
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Sridhar, Srikala S., Winquist, Eric, Eisen, Andrea, Hotte, Sebastien J., McWhirter, Elaine, Tannock, Ian F., Mukherjee, Som D., Wang, Lisa, Blattler, Chantale, Wright, John J., and Moore, Malcolm J.
- Published
- 2011
- Full Text
- View/download PDF
43. A phase II study of the antisense oligonucleotide GTI-2040 plus docetaxel and prednisone as first-line treatment in castration-resistant prostate cancer
- Author
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Sridhar, Srikala S., Canil, Christina M., Chi, Kim N., Hotte, Sebastien J., Ernst, Scott, Wang, Lisa, Chen, Eric X., Juhasz, Agnes, Yen, Yun, Murray, Peter, Zwiebel, James A., and Moore, Malcolm J.
- Published
- 2011
- Full Text
- View/download PDF
44. A phase II, multicenter study of cetuximab monotherapy in patients with refractory, metastatic colorectal carcinoma with absent epidermal growth factor receptor immunostaining
- Author
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Wierzbicki, Rafal, Jonker, Derek J., Moore, Malcolm J., Berry, Scott R., Loehrer, Patrick J., Youssoufian, Hagop, and Rowinsky, Eric K.
- Published
- 2011
- Full Text
- View/download PDF
45. Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection
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Neoptolemos, John P., Stocken, Deborah D., Bassi, Claudio, Ghaneh, Paula, Cunningham, David, Goldstein, David, Padbury, Robert, Moore, Malcolm J., Gallinger, Steven, Mariette, Christophe, Wente, Moritz N., Izbicki, Jakob R., Friess, Helmut, Lerch, Markus M., Dervenis, Christos, Olah, Attila, Butturini, Giovanni, Doi, Ryuichiro, Lind, Pehr A., Smith, David, Valle, Juan W., Palmer, Daniel H., Buckels, John A., Thompson, Joyce, McKay, Colin J., Rawcliffe, Charlotte L., and Buchler, Markus W.
- Subjects
Fluorouracil -- Comparative analysis ,Gemcitabine -- Comparative analysis ,Gemcitabine -- Health aspects ,Pancreatic cancer -- Drug therapy ,Postoperative care -- Methods ,Cancer -- Care and treatment ,Cancer -- Patient outcomes - Abstract
A study was conducted to evaluate and compare the safety and efficacy of adjuvant chemotherapy treatment with fluorouracil plus folinic acid as against gemcitabine following pancreatic cancer resection. Results indicated that treatment with fluorouracil plus folinic acid was found to be more effective than gemcitabine in improving outcomes in the case of such patients.
- Published
- 2010
46. Quality of Life in Patients With K-RAS Wild-Type Colorectal Cancer: The Co.20 Phase 3 Randomized Trial
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Ringash, Jolie, Au, Heather-Jane, Siu, Lillian L., Shapiro, Jeremy D., Jonker, Derek J., Zalcberg, John R., Moore, Malcolm J., Strickland, Andrew, Kotb, Rami, Jeffery, Mark, Alcindor, Thierry, Ng, Siobhan, Salim, Muhammad, Sabesan, Sabe, Easaw, Jay C., Shannon, Jenny, El-Tahche, Fabyolla, Walters, Ian, Tu, Dongsheng, and OʼCallaghan, Christopher J.
- Published
- 2014
- Full Text
- View/download PDF
47. A Phase 2 study of perifosine in advanced or metastatic breast cancer
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Leighl, Natasha B., Dent, Susan, Clemons, Mark, Vandenberg, Theodore A., Tozer, Richard, Warr, David G., Crump, R. Michael, Hedley, David, Pond, Gregory R., Dancey, Janet E., and Moore, Malcolm J.
- Published
- 2008
- Full Text
- View/download PDF
48. K-ras mutations and benefit from cetuximab in advanced colorectal cancer
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Karapetis, Christos S., Khambata-Ford, Shirin, Jonker, Derek J., O'Callaghan, Chris J., Tu, Dongsheng, Tebbutt, Niall C, Simes. R. John, Chalchal, Haji, Shapiro, Jeremy D., Robitaille, Sonia, Price, Timothy J., Shepherd, Lois, Au, Heather-Jane, Langer, Christiane, Moore, Malcolm J., and Zalcberg, John
- Subjects
Chemotherapy -- Health aspects ,Colorectal cancer -- Drug therapy ,Colorectal cancer -- Genetic aspects ,Colorectal cancer -- Patient outcomes ,Oncogenes -- Research ,Cancer -- Chemotherapy ,Cancer -- Health aspects - Abstract
A study was conducted to investigate whether mutation of the K-ras gene altered the effect of cetuximab in improving overall survival in patients with colorectal cancer that have not responded to chemotherapy. Results indicated that patients with a tumor bearing wild-type k-ras benefited from cetuximab, whereas those with mutated k-ras did not benefit.
- Published
- 2008
49. A phase II study of PS-341 (Bortezomib) in advanced or metastatic urothelial cancer. A trial of the Princess Margaret Hospital and University of Chicago phase II consortia
- Author
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Gomez-Abuin, Gonzalo, Winquist, Eric, Stadler, Walter M., Pond, Greg, Degendorfer, Pamela, Wright, John, and Moore, Malcolm J.
- Published
- 2007
- Full Text
- View/download PDF
50. Epidermal Growth Factor Receptor Antagonists in Pancreatic Cancer: What is Their Role?
- Author
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Tang, Patricia A. and Moore, Malcolm J.
- Published
- 2006
- Full Text
- View/download PDF
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