128 results on '"Moore, L. S."'
Search Results
2. Point-of-care SARS-CoV-2 serological assays for enhanced case finding in a UK inpatient population
- Author
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Pallett, S. J. C., Denny, S. J., Patel, A., Charani, E., Mughal, N., Stebbing, J., Davies, G. W., and Moore, L. S. P.
- Published
- 2021
- Full Text
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3. A Tunable Anomalous Hall Effect in a Non-Ferromagnetic System
- Author
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Cumings, J., Moore, L. S., Chou, H. T., Ku, K. C., Crooker, S. A., Samarth, N., and Goldhaber-Gordon, D.
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Materials Science - Abstract
We measure the low-field Hall resistivity of a magnetically-doped two-dimensional electron gas as a function of temperature and electrically-gated carrier density. Comparing these results with the carrier density extracted from Shubnikov-de Haas oscillations reveals an excess Hall resistivity that increases with decreasing temperature. This excess Hall resistivity qualitatively tracks the paramagnetic polarization of the sample, in analogy to the ferromagnetic anomalous Hall effect. The data are consistent with skew-scattering of carriers by disorder near the crossover to localization.
- Published
- 2005
- Full Text
- View/download PDF
4. Some Aspects of Inverse Compton Emission from 3K Background Photons
- Author
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Harris, D. E. and Moore, L. S.
- Subjects
Astrophysics - Abstract
We review the history and a few features of IC/3K emission. We discuss observing strategies, the physical parameters which can be derived directly or indirectly from successful detections, and the disparities between magnetic field strength estimates found by different methods., Comment: 4 pages latex with one embedded figure.Published in MPE Report 271, October 1999, page 219. Proceedings of the Ringberg workshop: "Diffuse Thermal and Relativistic Plasma in Galaxy Clusters", editors H. B\"{o}hringer, L. Feretti, and P. Schuecker
- Published
- 2000
5. Fluorescence Imaging for Cancer Screening and Surveillance
- Author
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Tipirneni, K. E., Rosenthal, E. L., Moore, L. S., Haskins, A. D., Udayakumar, N., Jani, A. H., Carroll, W. R., Morlandt, A. B., Bogyo, M., Rao, J., and Warram, Jason M.
- Published
- 2017
- Full Text
- View/download PDF
6. Experience of using beta-D-glucan assays in the intensive care unit
- Author
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Dagens, A., Mughal, N., Sisson, A., and Moore, L. S. P.
- Published
- 2018
- Full Text
- View/download PDF
7. Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
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Kousathanas, A., Pairo-Castineira, E., Rawlik, K., Stuckey, A., Odhams, C. A., Walker, S., Russell, C. D., Malinauskas, T., Wu, Y., Millar, J., Shen, X., Elliott, K. S., Griffiths, F., Oosthuyzen, W., Morrice, K., Keating, S., Wang, B., Rhodes, D., Klaric, L., Zechner, M., Parkinson, N., Siddiq, A., Goddard, P., Donovan, S., Maslove, D., Nichol, A., Semple, M. G., Zainy, T., Maleady-Crowe, F., Todd, L., Salehi, S., Knight, J., Elgar, G., Chan, G., Arumugam, P., Patch, C., Rendon, A., Bentley, D., Kingsley, C., Kosmicki, J. A., Horowitz, J. E., Baras, A., Abecasis, G. R., Ferreira, M. A. R., Justice, A., Mirshahi, T., Oetjens, M., Rader, D. J., Ritchie, M. D., Verma, A., Fowler, T. A., Shankar-Hari, M., Summers, C., Hinds, C., Horby, P., Mcauley, D., Montgomery, H., Openshaw, P. J. M., Elliott, P., Walsh, T., Tenesa, A., Fawkes, A., Murphy, L., Rowan, K., Ponting, C. P., Vitart, V., Wilson, J. F., Yang, J., Bretherick, A. D., Scott, R. H., Hendry, S. C., Moutsianas, L., Law, A., Caulfield, M. J., Baillie, J. K., Begg, C., Ling, L., Pereira, A. C., Aravindan, L., Armstrong, R., Biggs, H., Boz, C., Brown, A., Clark, R., Coutts, A., Coyle, J., Cullum, L., Das, S., Day, N., Donnelly, L., Duncan, E., Finernan, P., Fourman, M. H., Furlong, A., Furniss, J., Gallagher, B., Gilchrist, T., Golightly, A., Hafezi, K., Hamilton, D., Hendry, R., Law, D., Law, R., Law, S., Lidstone-Scott, R., Macgillivray, L., Maclean, A., Mal, H., Mccafferty, S., Mcmaster, E., Meikle, J., Moore, S. C., Murphy, S., Hellen, M., Zheng, C., Chen, J., Paterson, T., Schon, K., Stenhouse, A., Das, M., Swets, M., Szoor-McElhinney, H., Taneski, F., Turtle, L., Wackett, T., Ward, M., Weaver, J., Wrobel, N., Arbane, G., Bociek, A., Campos, S., Grau, N., Jones, T. O., Lim, R., Marotti, M., Ostermann, M., Whitton, C., Alldis, Z., Astin-Chamberlain, R., Bibi, F., Biddle, J., Blow, S., Bolton, M., Borra, C., Bowles, R., Burton, M., Choudhury, Y., Collier, D., Cox, A., Easthope, A., Ebano, P., Fotiadis, S., Gurasashvili, J., Halls, R., Hartridge, P., Kallon, D., Kassam, J., Lancoma-Malcolm, I., Matharu, M., May, P., Mitchelmore, O., Newman, T., Patel, M., Pheby, J., Pinzuti, I., Prime, Z., Prysyazhna, O., Shiel, J., Taylor, M., Tierney, C., Wood, S., Zak, A., Zongo, O., Bonner, S., Hugill, K., Jones, J., Liggett, S., Headlam, E., Bandla, N., Gellamucho, M., Davies, M., Thompson, C., Abdelrazik, M., Bakthavatsalam, D., Elhassan, M., Ganesan, A., Haldeos, A., Moreno-Cuesta, J., Purohit, D., Vincent, R., Xavier, K., Kumar, R., Frater, Alessia, Saleem, M., Carter, D., Jenkins, S., Lamond, Z., Wall, A., Fernandez-Roman, J., Hamilton, D. O., Johnson, E., Johnston, B., Martinez Guzman, Maria Loreto, Mulla, S., Shaw, D., Waite, A. A. C., Waugh, V., Welters, I. D., Williams, K., Cavazza, A., Cockrell, M., Corcoran, E., Depante, M., Finney, C., Jerome, E., Mcphail, M., Nayak, M., Noble, H., O'Reilly, K., Pappa, E., Saha, R., Saha, S., Smith, Jenovia Amisti, Knighton, A., Antcliffe, D., Banach, D., Brett, S., Coghlan, P., Fernandez, Z., Gordon, A., Rojo, R., Arias, S. S., Templeton, M., Meredith, M., Morris, L., Ryan, L., Clark, A., Sampson, J., Peters, C., Dent, M., Langley, M., Ashraf, Sana, Wei, S., Andrew, A., Bashyal, A., Davidson, N., Hutton, P., Mckechnie, S., Wilson, J., Baptista, D., Crowe, R., Fernandes, R., Herdman-Grant, R., Joseph, A., O'Connor, D., Allen, M., Loveridge, A., Mckenley, I., Morino, E., Naranjo, A., Simms, R., Sollesta, K., Swain, A., Venkatesh, H., Khera, J., Fox, J., Andrew, G., Barclay, L., Callaghan, M., Campbell, R., Clark, S., Hope, D., Marshall, L., Mcculloch, C., Briton, K., Singleton, J., Birch, S., Brimfield, L., Daly, Z., Pogson, D., Rose, S., Nown, A., Battle, C., Brinkworth, E., Harford, R., Murphy, C., Newey, L., Rees, T., Williams, M., Arnold, S., Polgarova, P., Stroud, K., Meaney, E., Jones, M., Ng, A., Agrawal, S., Pathan, N., White, D., Daubney, E., Elston, K., Grauslyte, L., Hussain, M., Phull, M., Pogreban, T., Rosaroso, L., Salciute, E., Franke, G., Wong, J., George, A., de Gordoa, L. O. -R., Peasgood, E., Phillips, C., Bates, M., Dasgin, J., Gill, J., Nilsson, A., Scriven, J., Collins, A., Khaliq, W., Gude, E. T., Delgado, C. C., Dawson, D., Ding, L., Durrant, G., Ezeobu, O., Farnell-Ward, S., Harrison, A., Kanu, R., Leaver, S., Maccacari, E., Manna, S., Saluzzio, R. P., Queiroz, J., Samakomva, T., Sicat, C., Texeira, J., Da Gloria, E. F., Lisboa, A., Rawlins, J., Mathew, J., Kinch, A., Hurt, W. J., Shah, N., Clark, V., Thanasi, M., Yun, N., Patel, K., Bennett, S., Goodwin, E., Jackson, M., Kent, A., Tibke, C., Woodyatt, W., Zaki, A., Abraheem, A., Bamford, P., Cawley, K., Dunmore, C., Faulkner, M., Girach, R., Jeffrey, H., Jones, R., London, E., Nagra, I., Nasir, F., Sainsbury, H., Smedley, C., Patel, T., Smith, M., Chukkambotla, S., Kazi, A., Hartley, J., Dykes, J., Hijazi, M., Keith, S., Khan, M., Ryan-Smith, J., Springle, P., Thomas, J., Truman, N., Saad, S., Coleman, D., Fine, C., Matt, R., Gay, B., Dalziel, J., Ali, S., Goodchild, D., Harling, R., Bhatterjee, R., Goddard, W., Davison, C., Duberly, S., Hargreaves, J., Bolton, R., Davey, M., Golden, D., Seaman, R., Cherian, S., Cutler, S., Heron, A. E., Roynon-Reed, A., Szakmany, T., Williams, G., Richards, O., Cheema, Y., Brooke, H., Buckley, S., Suarez, J. C., Charlesworth, R., Hansson, K., Norris, J., Poole, A., Rose, A., Sandhu, R., Sloan, B., Smithson, E., Thirumaran, M., Wagstaff, V., Metcalfe, A., Brunton, M., Caterson, J., Coles, H., Frise, M., Rai, S. G., Jacques, N., Keating, L., Tilney, E., Bartley, S., Bhuie, P., Gibson, S., Lyle, A., Mcneela, F., Radhakrishnan, J., Hughes, A., Yates, B., Reynolds, J., Campbell, H., Thompsom, M., Dodds, S., Duffy, S., Greer, S., Shuker, K., Tridente, A., Khade, R., Sundar, A., Tsinaslanidis, G., Birkinshaw, I., Carter, J., Howard, K., Ingham, J., Joy, R., Pearson, H., Roche, S., Scott, Z., Bancroft, H., Bellamy, M., Carmody, M., Daglish, J., Moore, F., Rhodes, J., Sangombe, M., Kadiri, S., Croft, M., White, I., Frost, V., Aquino, M., Jha, R., Krishnamurthy, V., Lim, L., Combes, E., Joefield, T., Monnery, S., Beech, V., Trotman, S., Christine, Almaden-Boyle, Austin, P., Cabrelli, L., Cole, S., Casey, M., Chapman, S., Whyte, C., Baird, Y., Butler, A., Chadbourn, I., Folkes, L., Fox, H., Gardner, A., Gomez, R., Hobden, G., Hodgson, L., King, K., Margarson, M., Martindale, T., Meadows, E., Raynard, D., Thirlwall, Y., Helm, D., Margalef, J., Criste, K., Cusack, R., Golder, K., Golding, H., Jones, O., Leggett, S., Male, M., Marani, M., Prager, K., Williams, T., Roberts, B., Salmon, K., Anderson, P., Archer, K., Austin, K., Davis, C., Durie, A., Kelsall, O., Thrush, J., Vigurs, C., Wild, L., Wood, H. -L., Tranter, H., Cowley, N., Mcalindon, M., Burtenshaw, A., Digby, S., Low, E., Morgan, A., Cother, N., Rankin, T., Clayton, S., Mccurdy, A., Ahmed, C., Baines, B., Clamp, S., Colley, J., Haq, R., Hayes, A., Hulme, J., Hussain, S., Joseph, S., Maqsood, Z., Purewal, M., Benham, L., Bradshaw, Z., Brown, J., Caswell, M., Cupitt, J., Melling, S., Preston, S., Slawson, N., Stoddard, E., Warden, S., Deacon, B., Lynch, C., Pothecary, C., Roche, L., Howe, G. S., Singh, Jaywant, Turner, K., Ellis, H., Stroud, N., Hunt, J., Dearden, J., Dobson, E., Drummond, A., Mulcahy, M., Munt, S., O'Connor, G., Philbin, J., Rishton, C., Tully, R., Winnard, S., Cathcart, S., Duffy, K., Puxty, A., Puxty, K., Turner, L., Ireland, J., Semple, G., Long, K., Whiteley, S., Wilby, E., Ogg, B., Cowton, A., Kay, Abigail, Kent, M., Potts, K., Wilkinson, A., Campbell, S., Brown, E., Melville, J., Naisbitt, J., Joseph, R., Lazo, M., Walton, O., Neal, A., Alexander, P., Allen, S., Bradley-Potts, J., Brantwood, C., Egan, J., Felton, T., Padden, G., Ward, L., Moss, S., Glasgow, S., Abel, L., Brett, M., Digby, B., Gemmell, L., Hornsby, J., Macgoey, P., O'Neil, P., Price, R., Rodden, N., Rooney, K., Sundaram, R., Thomson, N., Hopkins, B., Thrasyvoulou, L., Willis, H., Clark, M., Coulding, M., Jude, E., Mccormick, J., Mercer, O., Potla, D., Rehman, H., Savill, H., Turner, V., Downes, C., Holding, K., Riches, K., Hilton, M., Hayman, M., Subramanian, D., Daniel, P., Adanini, O., Bhatia, N., Msiska, M., Collins, R., Clement, I., Patel, B., Gulati, A., Hays, C., Webster, K., Hudson, A., Webster, A., Stephenson, E., Mccormack, L., Slater, V., Nixon, R., Hanson, H., Fearby, M., Kelly, S., Bridgett, V., Robinson, P., Camsooksai, J., Humphrey, C., Reschreiter, H., Wadams, B., Death, Y., Bastion, V., Clarke, D., David, B., Kent, H., Lorusso, Riccardo, Lubimbi, G., Murdoch, S., Penacerrada, M., Thomas, A., Valentine, J., Vochin, A., Wulandari, R., Djeugam, B., Bell, G., English, K., Katary, A., Wilcox, L., Bruce, M., Connolly, K., Duncan, T., Michael, H. T., Lindergard, G., Hey, S., Fox, C., Alfonso, J., Durrans, L. J., Guerin, J., Blackledge, B., Harris, J., Hruska, M., Eltayeb, A., Lamb, T., Hodgkiss, T., Cooper, L., Rothwell, J., Allan, A., Anderson, F., Kaye, C., Liew, J., Medhora, J., Scott, T., Trumper, E., Botello, A., Lankester, L., Nikitas, N., Wells, C., Stowe, B., Spencer, K., Brandwood, C., Smith, L., Birchall, K., Kolakaluri, L., Baines, D., Sukumaran, A., Apetri, E., Basikolo, C., Catlow, L., Charles, B., Dark, P., Doonan, R., Harvey, A., Horner, D., Knowles, K., Lee, S., Lomas, D., Lyons, C., Marsden, T., Mclaughlan, D., Mcmorrow, L., Pendlebury, J., Perez, J., Poulaka, M., Proudfoot, N., Slaughter, M., Slevin, K., Thomas, V., Walker, D., Michael, A., Collis, M., Cosier, T., Millen, G., Richardson, N., Schumacher, N., Weston, H., Rand, J., Baxter, N., Henderson, S., Kennedy-Hay, S., Mcparland, C., Rooney, L., Sim, M., Mccreath, G., Akeroyd, L., Bano, S., Bromley, M., Gurr, L., Lawton, T., Morgan, J., Sellick, K., Warren, D., Wilkinson, B., Mcgowan, J., Ledgard, C., Stacey, A., Pye, K., Bellwood, R., Bentley, M., Bewley, J., Garland, Z., Grimmer, L., Gumbrill, B., Johnson, R., Sweet, K., Webster, D., Efford, G., Convery, K., Fottrell-Gould, D., Hudig, L., Keshet-Price, J., Randell, G., Stammers, K., Bokhari, M., Linnett, V., Lucas, R., Mccormick, W., Ritzema, J., Sanderson, A., Wild, H., Rostron, A., Roy, A., Woods, L., Cornell, S., Wakinshaw, F., Rogerson, K., Jarmain, J., Parker, R., Reddy, A., Turner-Bone, I., Harding, P., Abernathy, C., Foster, L., Gratrix, A., Martinson, V., Parkinson, P., Stones, E., Carbral-Ortega, L., Bercades, G., Brealey, D., Hass, I., Maccallum, N., Martir, G., Raith, E., Reyes, A., Smyth, D., Zitter, L., Benyon, S., Marriott, S., Park, L., Keenan, S., Gordon, E., Quinn, H., Baines, K., Cagova, L., Fofano, A., Garner, L., Holcombe, H., Mepham, S., Mitchell, A. M., Mwaura, L., Praman, K., Vuylsteke, A., Zamikula, J., Purewal, B., Rivers, V., Bell, S., Blakemore, H., Borislavova, B., Faulkner, B., Gendall, E., Goff, E., Hayes, K., Thomas, M., Worner, R., Smith, K., Stephens, D., Mew, L., Mwaura, E., Stewart, R., Williams, F., Wren, L., Sutherland, S. -B., Bevan, E., Martin, J., Trodd, D., Watson, G., Brown, C. W., Akinkugbe, O., Bamford, A., Beech, E., Belfield, H., Bell, M., Davies, C., Jones, G. A. L., Mchugh, T., Meghari, H., O'Neill, L., Peters, M. J., Ray, S., Tomas, A. L., Burn, I., Hambrook, G., Manso, K., Penn, R., Shanmugasundaram, P., Tebbutt, J., Thornton, D., Cole, J., Davies, R., Duffin, D., Hill, H., Player, B., Thomas, E., Williams, A., Griffin, D., Muchenje, N., Mupudzi, M., Partridge, R., Conyngham, J. -A., Thomas, R., Wright, M., Corral, M. A., Jacob, R., Jones, C., Denmade, C., Beavis, S., Dale, K., Gascoyne, R., Hawes, J., Pritchard, K., Stevenson, L., Whileman, A., Doble, P., Hutter, J., Pawley, C., Shovelton, C., Vaida, M., Butcher, D., O'Sullivan, S., Butterworth-Cowin, N., Ahmad, N., Barker, J., Bauchmuller, K., Bird, S., Cawthron, K., Harrington, K., Jackson, Y., Kibutu, F., Lenagh, B., Masuko, S., Mills, G. H., Raithatha, A., Wiles, M., Willson, J., Newell, H., Lye, A., Nwafor, L., Jarman, C., Rowland-Jones, S., Foote, D., Thompson, R., Watson, J., Hesseldon, L., Macharia, I., Chetam, L., Ford, A., Anderson, S., Housley, K., Milner, L., Hanratty, H., Trower, H., Phillips, P., Oxspring, S., Donne, B., Jardine, C., Williams, D., Hay, A., Flanagan, R., Hughes, G., Latham, S., Mckenna, E., Anderson, J., Hull, R., Rhead, K., Cruz, C., Pattison, N., Charnock, R., Mcfarland, D., Cosgrove, D., Ahmed, A., Morris, A., Jakkula, S., Nune, A., Ali, Amjad, Brady, M., Dale, S., Dance, A., Gledhill, L., Greig, J., Hanson, K., Holdroyd, K., Home, M., Kelly, D., Kitson, R., Matapure, L., Melia, D., Mellor, S., Nortcliffe, T., Pinnell, J., Robinson, M., Shaw, L., Shaw, R., Thomis, L., Wilson, A., Wood, T., Bayo, L. -A., Merwaha, E., Ishaq, T., Hanley, S., Hibbert, M., Tetla, D., Woodford, C., Durga, L., Kennard-Holden, G., Branney, D., Frankham, J., Pitts, S., White, N., Laha, S., Verlander, M., Altabaibeh, A., Alvaro, A., Gilbert, K., Ma, L., Mostoles, L., Parmar, C., Simpson, K., Jetha, C., Booker, L., Pratley, A., Adams, C., Agasou, A., Arden, T., Bowes, A., Boyle, P., Beekes, M., Button, H., Capps, N., Carnahan, M., Carter, A., Childs, D., Donaldson, D., Hard, K., Hurford, F., Hussain, Y., Javaid, A., Jose, S., Leigh, M., Martin, T., Millward, H., Motherwell, N., Rikunenko, R., Stickley, J., Summers, J., Ting, L., Tivenan, H., Tonks, L., Wilcox, R., Skinner, D., Gaylard, J., Mullan, D., Newman, J., Holland, M., Keenan, N., Lyons, M., Wassall, H., Marsh, C., Mahenthran, M., Carter, E., Kong, T., Blackman, H., Creagh-Brown, B., Donlon, S., Michalak-Glinska, N., Mtuwa, S., Pristopan, V., Salberg, A., Smith, E., Stone, S., Piercy, C., Verula, J., Burda, D., Montaser, R., Harden, L., Mayangao, I., Marriott, C., Bradley, P., Harris, C., Andrews, E., Birch, J., Collins, E., Hammerton, K., O'Leary, R., Purvis, S., Barber, R., Hewitt, C., Hilldrith, A., Jackson-Lawrence, K., Shepardson, S., Wills, M., Butler, S., Tavares, S., Cunningham, A., Hindale, J., Arif, S., Bean, S., Burt, K., Spivey, M., Demetriou, C., Eckbad, C., Hierons, S., Howie, L., Mitchard, S., Ramos, L., Serrano-Ruiz, A., White, K., Kelly, F., Cristiano, D., Dormand, N., Farzad, Z., Gummadi, M., Liyanage, K., Salmi, S., Sloane, G., Thwaites, V., Varghese, M., Zborowski, A. C., Allan, J., Geary, T., Houston, G., Meikle, A., O'Brien, P., Forsey, M., Kaliappan, A., Nicholson, A., Riches, J., Vertue, M., Allan, E., Darlington, K., Davies, F., Easton, J., Kumar, S., Lean, R., Menzies, D., Pugh, R., Qiu, X., Davies, L., Williams, John Harford, Scanlon, J., Davies, G., Mackay, C., Lewis, J., Rees, S., Oblak, M., Popescu, M., Thankachen, M., Higham, A., Craig, J., Baruah, R., Morris, S., Ferguson, S., Shepherd, A., Moore, L. S. P., Vizcaychipi, M. P., de Almeida Martins, L. G., Carungcong, J., Ali, I. A. M., Beaumont, K., Blunt, M., Coton, Z., Curgenven, H., Elsaadany, M., Fernandes, K., Ally, S. M., Rangarajan, H., Sarathy, V., Selvanayagam, S., Vedage, D., White, M., Gill, M., Paul, P., Ratnam, V., Shelton, S., Wynter, I., Carmody, S., Page, V. J., Beith, C. M., Black, K., Clements, S., Morrison, A., Strachan, D., Clarkson, M., D'Sylva, S., Norman, K., Auld, F., Donnachie, J., Edmond, I., Prentice, L., Runciman, N., Salutous, D., Symon, L., Todd, A., Turner, P., Short, A., Sweeney, L., Murdoch, E., Senaratne, D., Hill, M., Kannan, T., Crawley, R., Crew, A., Cunningham, M., Daniels, A., Harrison, L., Hope, S., Inweregbu, K., Jones, S., Lancaster, N., Matthews, J., Wray, G., Langton, H., Prout, R., Watters, M., Novis, C., Barron, A., Collins, C., Kaul, S., Passmore, H., Prendergast, C., Reed, A., Rogers, P., Shokkar, R., Woodruff, M., Middleton, H., Polgar, O., Nolan, C., Mahay, K., Hormis, A., Maynard, V., Graham, C., Walker, R., Knights, E., Price, A., Thorpe, C., Behan, T., Burnett, C., Hatton, J., Heeney, E., Mitra, A., Newton, M., Pollard, R., Stead, R., Amin, V., Anastasescu, E., Anumakonda, V., Karthik, K., Kausar, R., Reid, K., Imeson-Wood, J., Crickmore, V., Debreceni, G., Wilkins, J., Nicol, L., Reece-Anthony, R., Birt, M., Ghosh, A., Williams, E., Allen, L., Beranova, E., Crisp, N., Deery, J., Hazelton, T., Knight, A., Price, C., Tilbey, S., Turki, S., Turney, S., Cooper, J., Finch, C., Liderth, S., Quinn, A., Waddington, N., Coventry, T., Fowler, S., Macmahon, M., Mcgregor, A., Cowley, A., Highgate, J., Gregory, J., O'Connell, S., Smith, T., Barberis, Lorenzo, Gopal, S., Harris, N., Lake, V., Metherell, S., Radford, E., Daniel, A., Finn, J., Donnison, P., Trim, F., Eapen, B., Bough, L., Goodsell, J., Tutton, R., Williams, P., Williams, S., Winter-Goodwin, B., Brickell, K., Smyth, M., Coetzee, S., Gales, A., Raj, M., Sell, C., Hilltout, P., Evitts, J., Tyler, A., Waldron, J., Beesley, K., Board, S., Kubisz-Pudelko, A., Lewis, A., Perry, J., Pippard, L., Wood, Dawn, Buckley, C., Barry, P., Flint, N., Rekha, P., Hales, D., Bunni, L., Jennings, C., Latif, Marco, Marshall, R., Subramanian, G., Mcguigan, P. J., Wasson, C., Finn, Stephen Edward, Green, J., King, B., Campbell, A., Smuts, S., Duffield, J., Smith, O., Mallon, L., Watkins, C., Botfield, L., Butler, J., Dexter, C., Fletcher, J., Garg, A., Kuravi, A., Ranga, P., Virgilio, E., Belagodu, Z., Fuller, B., Gherman, A., Olufuwa, O., Paramsothy, R., Stuart, C., Oakley, N., Kamundi, C., Tyl, D., Collins, K., Silva, P., Taylor, J., King, L., Coates, C., Crowley, M., Wakefield, P., Beadle, J., Johnson, L., Sargeant, J., Anderson, M., Brady, A., Chan, R., Little, J., Mcivor, S., Prady, H., Whittle, H., Mathew, B., Attwood, B., Parsons, P., Ward, G., Bremmer, P., Joe, W., Tracy, B., Jim, R., Davies, E., Sathe, S., Dennis, C., Parris, V., Srikaran, S., Sukha, A., Clarke, N., Whiteside, J., Mascarenhas, M., Donaldson, A., Matheson, J., Barrett, F., O'Hara, M., Okeefe, L., Bradley, C., Eastgate-Jackson, C., Filipe, H., Martin, D., Maharajh, A., Garcia, S. M., Pakou, G., De Neef, M., Dent, K., Horsley, E., Akhtar, M. 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A., Thomas, H., Rees, A., Duskova, M., Phipps, J., Brooks, S., Edwards, M., Quaid, S., Watson, E., Brayne, A., Fisher, E., Jackson, P., Kaye, D., Love, N., Parkin, J., Tuckey, V., van Koutrik, L., Carter, S., Andrew, B., Findlay, L., Adams, K., Service, J., Cheyne, C., Saunderson, A., Moultrie, S., Odam, M., Hall, K., Mapfunde, I., Willis, C., Lyon, A., Sri-Chandana, C., Scherewode, J., Stephenson, L., Marsh, S., Hardy, J., Houlden, H., Moncur, E., Tariq, A., Tucci, Domenico Antonio, Hobrok, M., Loosley, R., Mcguinness, H., Tench, H., Wolf-Roberts, R., Irvine, V., Shelley, B., Gorman, C., Gupta, A., Timlick, E., Brady, R., Milligan, B., Bellini, A., Bryant, J., Mayer, A., Pickard, A., Roe, N., Sowter, J., Howlett, A., Fidler, K., Tagliavini, E., Donnelly, K., Shelton, J. F., Shastri, A. J., Ye, C., Weldon, C. H., Filshtein-Sonmez, T., Coker, D., Symons, A., Esparza-Gordillo, J., Aslibekyan, S., Auton, A., Pathak, G. A., Karjalainen, J., Stevens, C., Andrews, S. J., Kanai, M., Cordioli, M., Polimanti, R., Pirinen, M., Harerimana, N., Veerapen, K., Wolford, B., Nguyen, H., Solomonson, M., Liao, R. G., Chwialkowska, K., Trankiem, A., Balaconis, M. K., Hayward, C., Richmond, A., Morris, M., Fawns-Ritchie, C., Glessner, J. T., Shaw, D. M., Chang, X., Polikowski, H., Petty, L. E., Chen, H. -H., Wanying, Z., Porteous, D. J., Below, J., North, K., Mccormick, J. B., Timmers, P. H. J., D'Mellow, K., Kerr, S. M., Niemi, M. E. K., Nkambul, L., von Hohenstaufen, K. A., Sobh, A., Eltoukhy, M. M., Yassen, A. M., Hegazy, M. A. F., Okasha, K., Eid, M. A., Moahmed, H. S., Shahin, D., El-Sherbiny, Y. M., Elhadidy, T. A., Abd Elghafar, M. S., El-Jawhari, J. J., Mohamed, A. A. S., Elnagdy, M. H., Samir, A., Abdel-Aziz, M., Khafaga, W. T., El-Lawaty, W. A., Torky, M. S., El-shanshory, M. R., Batini, C., Lee, P. H., Shrine, N., Williams, A. T., Tobin, M. D., Guyatt, A. L., John, C., Packer, R. J., Free, R. C., Wang, X., Wain, L. V., Hollox, E. J., Venn, L. D., Bee, C. E., Adams, Mary Elizabeth, Niavarani, A., Sharififard, B., Aliannejad, R., Amirsavadkouhi, A., Naderpour, Z., Tadi, H. A., Aleagha, A. E., Ahmadi, S., Moghaddam, S. B. M., Adamsara, A., Saeedi, M., Abdollahi, H., Hosseini, A., Chariyavilaskul, P., Chamnanphon, M., Suttichet, T. B., Shotelersuk, V., Pongpanich, M., Phokaew, C., Chetruengchai, W., Jantarabenjakul, W., Putchareon, O., Torvorapanit, P., Puthanakit, T., Suchartlikitwong, P., Hirankarn, N., Nilaratanakul, V., Sodsai, P., Brumpton, B. M., Hveem, K., Willer, C., Zhou, W., Rogne, T., Solligard, E., Asvold, B. O., Abedalthagafi, M., Alaamery, M., Alqahtani, S., Barakeh, D., Harthi, F. A., Alsolm, E., Safieh, L. A., Alowayn, A. M., Alqubaishi, F., Mutairi, A. A., Mangul, S., Alshareef, A., Sawaji, M., Almutairi, M., Aljawini, N., Albesher, N., Arabi, Y. M., Mahmoud, E. S., Khattab, A. K., Halawani, R. T., Alahmadey, Z. Z., Albakri, J. K., Felemban, W. A., Suliman, B. A., Hasanato, R., Al-Awdah, L., Alghamdi, J., Alzahrani, D., Aljohani, S., Al-Afghani, H., Alrashed, M., Aldhawi, N., Albardis, H., Alkwai, S., Alswailm, M., Almalki, F., Albeladi, M., Almohammed, I., Barhoush, E., Albader, A., Massadeh, S., Almalik, A., Alotaibi, S., Alghamdi, B., Jung, J., Fawzy, M. S., Lee, Y., Magnus, P., Trogstad, L. -I. S., Helgeland, O., Harris, J. R., Mangino, M., Spector, T. D., Smieszek, S. P., Przychodzen, B. P., Polymeropoulos, C., Polymeropoulos, V., Polymeropoulos, M. H., Fernandez-Cadenas, I., Perez-Tur, J., Llucia-Carol, L., Cullell, N., Muino, E., Carcel-Marquez, J., Dediego, M. L., Iglesias, L. L., Planas, A. M., Soriano, A., Rico, V., Aguero, D., Bedini, J. L., Lozano, F., Domingo, C., Robles, V., Ruiz-Jaen, F., Marquez, L., Gomez, J., Coto, E., Albaiceta, G. M., Garcia-Clemente, M., Dalmau, D., Arranz, M. J., Dietl, B., Serra-Llovich, A., Soler, P., Colobran, R., Martin-Nalda, A., Martinez, A. P., Bernardo, D., Rojo, S., Fiz-Lopez, A., Arribas, E., de la Cal-Sabater, P., Segura, T., Gonzalez-Villa, E., Serrano-Heras, G., Marti-Fabregas, J., Jimenez-Xarrie, E., Mimbrera, A. F., Masjuan, J., Garcia-Madrona, S., Dominguez-Mayoral, A., Villalonga, J. M., Menendez-Valladares, P., Chasman, D. I., Buring, J. E., Ridker, P. M., Franco, G., Sesso, H. D., Manson, J. E., Glessner, J. R., Hakonarson, H., Medina-Gomez, C., Uitterlinden, A. G., Ikram, M. A., Kristiansson, K., Koskelainen, S., Perola, M., Donner, K., Kivinen, K., Palotie, A., Ripatti, S., Ruotsalainen, S., Kaunisto, M., Nakanishi, T., Butler-Laporte, G., Forgetta, V., Morrison, D. R., Ghosh, B., Laurent, L., Belisle, A., Henry, D., Abdullah, T., Adeleye, O., Mamlouk, N., Kimchi, N., Afrasiabi, Z., Rezk, N., Vulesevic, B., Bouab, M., Guzman, C., Petitjean, L., Tselios, C., Xue, X., Schurr, E., Afilalo, J., Afilalo, M., Oliveira, M., Brenner, B., Lepage, P., Ragoussis, J., Auld, D., Brassard, N., Durand, M., Chasse, M., Kaufmann, D. E., Lathrop, G. M., Mooser, V., Richards, J. B., Li, R., Adra, D., Rahmouni, S., Georges, M., Moutschen, M., Misset, B., Darcis, G., Guiot, J., Guntz, J., Azarzar, S., Gofflot, S., Beguin, Y., Claassen, S., Malaise, O., Huynen, P., Meuris, C., Thys, M., Jacques, J., Leonar, P., Frippiat, F., Giot, J. -B., Sauvage, A. -S., von Frenckell, C., Belhaj, Y., Lambermont, B., Pigazzini, S., Daya, M., Shortt, J., Rafaels, N., Wicks, S. J., Crooks, K., Barnes, K. C., Gignoux, C. R., Chavan, S., Laisk, T., Lall, K., Lepamets, M., Magi, R., Esko, T., Reimann, E., Milani, Luca, Alavere, H., Metsalu, K., Puusepp, M., Metspalu, A., Naaber, P., Laane, E., Pesukova, J., Peterson, P., Kisand, K., Tabri, J., Allos, R., Hensen, K., Starkopf, J., Ringmets, I., Tamm, A., Kallaste, A., Bochud, P. -Y., Rivolta, C., Bibert, S., Quinodoz, M., Kamdar, D., Boillat, N., Nussle, S. G., Albrich, W., Suh, N., Neofytos, D., Erard, V., Voide, C., de Cid, R., Galvan-Femenia, I., Blay, N., Carreras, A., Cortes, B., Farre, X., Sumoy, L., Moreno, V., Mercader, J. M., Guindo-Martinez, M., Torrents, D., Kogevinas, M., Garcia-Aymerich, J., Castano-Vinyals, G., Dobano, C., Renieri, A., Mari, F., Fallerini, C., Daga, S., Benetti, E., Baldassarri, M., Fava, F., Frullanti, E., Valentino, Francesca, Doddato, G., Giliberti, A., Tita, R., Amitrano, S., Bruttini, M., Croci, S., Meloni, I., Mencarelli, Marta, Rizzo, C. L., Pinto, A. M., Beligni, G., Tommasi, A., Sarno, L. D., Palmieri, Marco, Carriero, M. L., Alaverdian, D., Busani, S., Bruno, R., Vecchia, M., Belli, M. A., Picchiotti, N., Sanarico, M., Gori, Mario, Furini, S., Mantovani, Susanna, Ludovisi, S., Mondelli, M. U., Castelli, F., Quiros-Roldan, E., Antoni, M. D., Zanella, I., Vaghi, M., Rusconi, S., Siano, M., Montagnani, F., Emiliozzi, A., Fabbiani, M., Rossetti, Barbara, Bargagli, E., Bergantini, L., D'Alessandro, Michele, Cameli, P., Bennett, D., Anedda, F., Marcantonio, S., Scolletta, S., Franchi, Francesca, Mazzei, M. A., Guerrini, S., Conticini, E., Cantarini, L., Frediani, B., Tacconi, D., Spertilli, C., Feri, M., Donati, Andrea, Scala, R., Guidelli, L., Spargi, G., Corridi, M., Nencioni, C., Croci, L., Bandini, M., Caldarelli, G. P., Piacentini, P., Desanctis, E., Cappelli, S., Canaccini, A., Verzuri, A., Anemoli, V., Ognibene, A., Pancrazzi, A., Lorubbio, M., Monforte, A. D., Miraglia, F. G., Girardis, M., Venturelli, S., Cossarizza, A., Antinori, Armando, Vergori, A., Gabrieli, A., Riva, A., Francisci, D., Schiaroli, E., Paciosi, F., Scotton, P. G., Andretta, F., Panese, S., Scaggiante, R., Gatti, F., Parisi, S. G., Baratti, S., Monica, M. D., Piscopo, C., Capasso, Monica, Russo, R., Andolfo, I., Iolascon, A., Fiorentino, Giuseppe, Carella, M., Castori, M., Merla, G., Squeo, G. M., Aucella, F., Raggi, P., Marciano, C., Perna, Raffaella, Bassetti, M., Biagio, A. D., Sanguinetti, Maurizio, Masucci, Luca, Valente, S., Mandala, M., Giorli, A., Salerni, L., Zucchi, P., Parravicini, P., Menatti, E., Trotta, T., Giannattasio, F., Coiro, G., Lena, Francesco, Coviello, D. A., Mussini, C., Martinelli, E., Mancarella, S., Tavecchia, L., Crotti, L., Gabbi, Chiara, Rizzi, M., Maggiolo, F., Ripamonti, D., Bachetti, T., Rovere, M. T. L., Sarzi-Braga, S., Bussotti, M., Ceri, S., Pinoli, P., Raimondi, F., Biscarini, F., Stella, A., Zguro, K., Capitani, K., Suardi, C., Dei, S., Parati, G., Ravaglia, S., Artuso, R., Botta, Giovanni, Di Domenico, Pasqualina, Rancan, I., Perrella, A., Bianchi, F., Romani, D., Bergomi, P., Catena, E., Colombo, R., Tanfoni, M., Vincenti, A., Ferri, C., Grassi, D., Pessina, Gloria, Tumbarello, Mario, Di Pietro, Maria Luisa, Sabrina, R., Luchi, S., Barbieri, Cristiano, Acquilini, D., Andreucci, E., Segala, F. V., Tiseo, G., Falcone, M., Lista, Maddalena, Poscente, M., De Vivo, O., Petrocelli, Paolo, Guarnaccia, A., Baroni, S., Smith, A. V., Boughton, A. P., Li, K. W., Lefaive, J., Annis, A., Chittoor, G., Josyula, N. S., Leader, J. B., Carey, D. J., Gass, M. C., Cantor, M. N., Yadav, A., van Heel, D. A., Hunt, K. A., Mason, D., Huang, Q. Q., Finer, S., Trivedi, B., Griffiths, C. J., Martin, H. C., Wright, J., Trembath, R. C., Soranzo, N., Zhao, J. H., Butterworth, A. S., Danesh, J., Di Angelantonio, E., Franke, L., Boezen, M., Deelen, P., Claringbould, A., Lopera, E., Warmerdam, R., Vonk, J. M., van Blokland, I., Lanting, P., Ori, A. P. S., Zollner, S., Wang, J., Beck, A., Peloso, G., Ho, Y. -L., Sun, Y. V., Huffman, J. E., O'Donnell, C. J., Cho, K., Tsao, P., Gaziano, J. M., Nivard, M., de Geus, E., Bartels, M., Hottenga, J. J., Weiss, S. T., Karlson, E. W., Smoller, J. W., Green, R. C., Feng, Y. -C. A., Mercader, J., Murphy, S. N., Meigs, J. B., Woolley, A. E., Perez, E. F., Rader, D., Li, B., Verma, S. S., Lucas, A., Bradford, Y., Zeberg, H., Frithiof, R., Hultstrom, M., Lipcsey, M., Tardif, N., Rooyackers, O., Grip, J., Maricic, T., Karczewski, K. J., Atkinson, E. G., Tsuo, K., Baya, N., Turley, P., Gupta, R., Callier, S., Walters, R. K., Palmer, D. S., Sarma, G., Cheng, N., Lu, W., Bryant, S., Churchhouse, C., Cusick, C., Goldstein, J. I., King, D., Seed, C., Finucane, H., Martin, A. R., Satterstrom, F. K., Wilson, D. J., Armstrong, J., Rudkin, J. K., Band, G., Earle, S. G., Lin, S. -K., Arning, N., Crook, D. W., Wyllie, D. H., O'Connell, A. M., Spencer, C. C. A., Koelling, N., Fowler, T., Pasko, D., Ball, C. A., Hong, E. L., Rand, K., Girshick, A., Guturu, H., Baltzell, A. H., Roberts, G., Park, D., Coignet, M., Mccurdy, S., Knight, S., Partha, R., Rhead, B., Zhang, M., Berkowitz, N., Gaddis, M., Noto, K., Ruiz, L., Pavlovic, M., Sloofman, L. G., Charney, A. W., Beckmann, N. D., Schadt, E. E., Jordan, D. M., Thompson, R. C., Gettler, K., Abul-Husn, N. S., Ascolillo, S., Buxbaum, J. D., Chaudhary, K., Cho, J. H., Itan, Y., Kenny, E. E., Belbin, G. M., Sealfon, S. C., Sebra, R. P., Salib, I., Collins, B. L., Levy, T., Britvan, B., Keller, K., Tang, L., Peruggia, M., Hiester, L. L., Niblo, K., Aksentijevich, A., Labkowsky, A., Karp, A., Zlatopolsky, M., Preuss, M., Loos, R. J. F., Nadkarni, G. N., Do, R., Hoggart, C., Choi, S., Underwood, S. J., O'Reilly, P., Huckins, L. M., Zyndorf, M., Daly, M. J., Neale, B. M., Ganna, A., Frater A., Martinez M. L., Smith J., Ashraf S., Singh J., Kay A., Lorusso R., Ali A., Williams H., Barberis L., Wood D. (ORCID:0000-0001-8588-8931), Latif M., Finn S., Taylor A., Tucci A., Adams E. L., Milani L. (ORCID:0000-0003-0218-458X), Valentino F., Mencarelli M. A., Palmieri M. (ORCID:0000-0001-8263-336X), Gori M., Mantovani S., Rossetti B., D'Alessandro M., Franchi F., Donati A., Antinori A. (ORCID:0000-0002-6019-2417), Capasso M., Fiorentino G., Perna R., Sanguinetti M. (ORCID:0000-0002-9780-7059), Masucci L. (ORCID:0000-0002-8358-6726), Lena F. (ORCID:0000-0001-5528-319X), Gabbi C., Botta G., Di Domenico P., Pessina G., Tumbarello M. (ORCID:0000-0002-9519-8552), Di Pietro M. (ORCID:0000-0002-3893-8788), Barbieri C., Lista M., and Petrocelli P.
- Abstract
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease.
- Published
- 2022
8. The Modern Thrombolites of Lake Clifton, Western Australia
- Author
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Moore, L. S., Burne, R. V., Bertrand-Sarfati, Janine, editor, and Monty, Claude, editor
- Published
- 1994
- Full Text
- View/download PDF
9. Exploring the epidemiology of carbapenem-resistant Gram-negative bacteria in west London and the utility of routinely collected hospital microbiology data
- Author
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Freeman, R., Moore, L. S. P., Charlett, A., Donaldson, H., and Holmes, A. H.
- Published
- 2015
- Full Text
- View/download PDF
10. Community-acquired Klebsiella pneumoniae liver abscess: the London experience
- Author
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Moore, L. S. P., Clarke, I. L., Donaldson, H., and Azadian, B.
- Published
- 2014
- Full Text
- View/download PDF
11. Is there a role for using mobile device applications to support antimicrobial stewardship? Preliminary findings from a survey of general practitioners in the United Kingdom: 0072
- Author
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McLeod, M., Gharbi, M., Charani, E., Castro-Sanchez, E., Moore, L. S. P., Gilchrist, M., and Holmes, A.
- Published
- 2014
12. An analysis of the development and implementation of a smartphone application for the delivery of antimicrobial prescribing policy: lessons learnt
- Author
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Charani, E., Kyratsis, Y., Lawson, W., Wickens, H., Brannigan, E. T., Moore, L. S. P., and Holmes, A. H.
- Published
- 2013
- Full Text
- View/download PDF
13. Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner ear balance organs.
- Author
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Wang, T., Ling, A. H., Billings, S. E., Hosseini, D. K., Vaisbuch, Y., Kim, G. S., Atkinson, P. J., Sayyid, Z. N., Aaron, K. A., Wagh, D., Pham, N., Scheibinger, M., Zhou, R., Ishiyama, A., Moore, L. S., Santa Maria, P., Blevins, N. H., Jackler, R. K., Alyono, J. C., and Kveton, J.
- Subjects
EAR diseases ,CONFERENCES & conventions ,REGENERATION (Biology) ,RNA ,GENE expression profiling ,INNER ear ,SEQUENCE analysis - Abstract
Mammalian inner ear hair cell loss leads to permanent hearing and balance dysfunction. In contrast to the cochlea, vestibular hair cells of the murine utricle have some regenerative capacity. Whether human utricular hair cells regenerate in vivo remains unknown. Here we procured live, mature utricles from organ donors (9 ears from 6 organ donors) and vestibular schwannoma patients (24 ears from 24 patients), and presented a single-cell transcriptomic atlas at unprecedented resolution. We validated marker genes using immunostaining and RNAscope in situ hybridization and described previously unknown markers of 13 sensory and non-sensory cell types. In addition, we compared and found partial overlap and correlation between transcriptomes of human and mouse hair cells and supporting cells. We further uncovered transcriptomes unique to hair cell precursors, which are validated in both organ donor and vestibular schwannoma utricles. Unexpectedly we found 14-fold more hair cell precursors in vestibular schwannoma utricles, demonstrating the existence of ongoing regeneration in humans. Lastly, supporting cell-to-hair cell trajectory analysis revealed 5 distinct patterns of dynamic gene expression and associated pathways. Our data-set constitutes a foundational resource, accessible via a web-based interface, serving to advance knowledge of the normal and diseased human inner ear. [ABSTRACT FROM AUTHOR]
- Published
- 2024
14. Involving citizens in priority setting for public health research: Implementation in infection research
- Author
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Rawson, T. M., Castro-Sánchez, E., Charani, E., Husson, F., Moore, L. S. P., Holmes, A. H., Ahmad, R., National Institute for Health Research, and NIHR Imperial Biomedical Research Centre (BRC)
- Subjects
Adult ,Male ,patient & public engagement ,Decision Making ,1110 Nursing ,Communicable Diseases ,Communicable Diseases, Emerging ,Resource Allocation ,RA0421 ,Humans ,Aged ,Health Priorities ,Community Participation ,Drug Resistance, Microbial ,Focus Groups ,Middle Aged ,Original Research Paper ,1117 Public Health And Health Services ,1701 Psychology ,infection funding ,Public Opinion ,Female ,Public Health ,strategic decision making ,Health Services Research ,Original Research Papers - Abstract
Background Public sources fund the majority of UK infection research, but citizens currently have no formal role in resource allocation. To explore the feasibility and willingness of citizens to engage in strategic decision making, we developed and tested a practical tool to capture public priorities for research. Method A scenario including six infection themes for funding was developed to assess citizen priorities for research funding. This was tested over two days at a university public festival. Votes were cast anonymously along with rationale for selection. The scenario was then implemented during a three‐hour focus group exploring views on engagement in strategic decisions and in‐depth evaluation of the tool. Results 188/491(38%) prioritized funding research into drug‐resistant infections followed by emerging infections(18%). Results were similar between both days. Focus groups contained a total of 20 citizens with an equal gender split, range of ethnicities and ages ranging from 18 to >70 years. The tool was perceived as clear with participants able to make informed comparisons. Rationale for funding choices provided by voters and focus group participants are grouped into three major themes: (i) Information processing; (ii) Knowledge of the problem; (iii) Responsibility; and a unique theme within the focus groups (iv) The potential role of citizens in decision making. Divergent perceptions of relevance and confidence of “non‐experts” as decision makers were expressed. Conclusion Voting scenarios can be used to collect, en‐masse, citizens' choices and rationale for research priorities. Ensuring adequate levels of citizen information and confidence is important to allow deployment in other formats.
- Published
- 2017
15. Cutaneotrichosporon ( Trichosporon ) debeurmannianum associated with a subcutaneous mycotic cyst successfully treated with voriconazole
- Author
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Noy, M. L., primary, Abdolrasouli, A., additional, Borman, A. M., additional, Fraser, M., additional, Francis, N., additional, Moore, L. S. P., additional, and Merika, E. E., additional
- Published
- 2019
- Full Text
- View/download PDF
16. Cutaneotrichosporon (Trichosporon) debeurmannianum associated with a subcutaneous mycotic cyst successfully treated with voriconazole.
- Author
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Noy, M. L., Abdolrasouli, A., Borman, A. M., Fraser, M., Francis, N., Moore, L. S. P., and Merika, E. E.
- Subjects
TRICHOSPORON ,QUESTIONING - Abstract
Click here for the corresponding questions to this CME article. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
17. Supervised machine learning for the prediction of infection on admission to hospital: a prospective observational cohort study
- Author
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Rawson, T M, primary, Hernandez, B, additional, Moore, L S P, additional, Blandy, O, additional, Herrero, P, additional, Gilchrist, M, additional, Gordon, A, additional, Toumazou, C, additional, Sriskandan, S, additional, Georgiou, P, additional, and Holmes, A H, additional
- Published
- 2018
- Full Text
- View/download PDF
18. What are the factors driving antimicrobial resistance? Perspectives from a public event in London, England
- Author
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Castro-Sanchez, E., Moore, L. S. P., Husson, F., and Holmes, A. H.
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RA ,QR - Abstract
BACKGROUND: Antimicrobial resistance is driven by multiple factors. Resolving the threat to human and animal health presented by drug-resistant infections remains a societal challenge that demands close collaboration between scientists and citizens. We compared current public views about key contributing factors to antimicrobial resistance with those expressed by experts. \ud \ud METHODS: Overarching factors contributing to antimicrobial resistance were identified following a review of literature. The factors were then described in plain language and attached to ballot boxes at a public engagement event organised by a university. Responses to each factor were counted at the end of the event. \ud \ud RESULTS: Four hundred five responses were received from 3750 visitors (11 % response rate). Nearly half of responses (192/405, 47 · 4 %) considered the misuse/overuse of antibiotics in humans as the main determinant of antimicrobial resistance. The misuse of antibiotics in animal health obtained 16 · 3 % (66/405) responses. However, the lack of quick tests to diagnose infections received 10/405 votes (2 · 47 %), and the lack of effective vaccines received one vote (0 · 25 %). \ud \ud CONCLUSIONS: The majority of responses ascribed the emergence of drug-resistant infections to the misuse of antibiotics in human and animals. Suboptimal dosing, availability of diagnostics and environmental contamination were considered less influential on the development of antimicrobial resistance. The growing recognition of broader multifaceted drivers of drug resistance by experts is not yet echoed in the public mind.
- Published
- 2016
19. Patient engagement with infection management in secondary care: a qualitative investigation of current experiences
- Author
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Rawson, T. M., Moore, L. S. P., Hernandez, B., Castro-Sanchez, E., Charani, E., Georgiou, P., Ahmad, R., Holmes, A. H., Imperial College Healthcare NHS Trust, and National Institute for Health Research
- Subjects
Male ,Decision Making ,shared decision making ,Secondary Care ,antimicrobials ,Young Adult ,Anti-Infective Agents ,Humans ,Qualitative Research ,Aged ,Infection-prevention ,Research ,Communication ,Reproducibility of Results ,Drug Resistance, Microbial ,Bacterial Infections ,INFECTIOUS DISEASES ,Focus Groups ,R1 ,United Kingdom ,QR ,Female ,Patient Participation ,RA - Abstract
OBJECTIVE: To understand patient engagement with decision-making for infection management in secondary care and the consequences associated with current practices. \ud \ud DESIGN: A qualitative investigation using in-depth focus groups. \ud \ud PARTICIPANTS: Fourteen members of the public who had received antimicrobials from secondary care in the preceding 12 months in the UK were identified for recruitment. Ten agreed to participate. All participants had experience of infection management in secondary care pathways across a variety of South-East England healthcare institutes. Study findings were subsequently tested through follow-up focus groups with 20 newly recruited citizens. \ud \ud RESULTS: Participants reported feelings of disempowerment during episodes of infection in secondary care. Information is communicated in a unilateral manner with individuals 'told' that they have an infection and will receive an antimicrobial (often unnamed), leading to loss of ownership, frustration, anxiety and ultimately distancing them from engaging with decision-making. This poor communication drives individuals to seek information from alternative sources, including online, which is associated with concerns over reliability and individualisation. Failures in communication and information provision by clinicians in secondary care influence individuals' future ideas about infections and their management. This alters their future actions towards antimicrobials and can drive prescription non-adherence and loss to follow-up. \ud \ud CONCLUSIONS: Current infection management and antimicrobial prescribing practices in secondary care fail to engage patients with the decision-making process. Secondary care physicians must not view infection management episodes as discrete events, but as cumulative experiences which have the potential to shape future patient behaviour and understanding of antimicrobial use.
- Published
- 2016
20. Delivering precision antimicrobial therapy through closed-loop control systems
- Author
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Rawson, T M, primary, O’Hare, D, additional, Herrero, P, additional, Sharma, S, additional, Moore, L S P, additional, de Barra, E, additional, Roberts, J A, additional, Gordon, A C, additional, Hope, W, additional, Georgiou, P, additional, Cass, A E G, additional, and Holmes, A H, additional
- Published
- 2017
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21. Effect of adding a mobile health intervention to a multimodal antimicrobial stewardship programme across three teaching hospitals: an interrupted time series study
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Charani, E., primary, Gharbi, M., additional, Moore, L. S. P., additional, Castro-Sanchéz, E., additional, Lawson, W., additional, Gilchrist, M., additional, and Holmes, A. H., additional
- Published
- 2017
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22. Supervised machine learning for the prediction of infection on admission to hospital: a prospective observational cohort study.
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Rawson, T M, Hernandez, B, Moore, L S P, Blandy, O, Herrero, P, Gilchrist, M, Gordon, A, Toumazou, C, Sriskandan, S, Georgiou, P, and Holmes, A H
- Subjects
MACHINE learning ,COHORT analysis ,BILIRUBIN ,C-reactive protein ,RECEIVER operating characteristic curves - Abstract
Background: Infection diagnosis can be challenging, relying on clinical judgement and non-specific markers of infection. We evaluated a supervised machine learning (SML) algorithm for diagnosing bacterial infection using routinely available blood parameters on presentation to hospital.Methods: An SML algorithm was developed to classify cases into infection versus no infection using microbiology records and six available blood parameters (C-reactive protein, white cell count, bilirubin, creatinine, ALT and alkaline phosphatase) from 160203 individuals. A cohort of patients admitted to hospital over a 6 month period had their admission blood parameters prospectively inputted into the SML algorithm. They were prospectively followed up from admission to classify those who fulfilled clinical case criteria for a community-acquired bacterial infection within 72 h of admission using a pre-determined definition. Predictive ability was assessed using receiver operating characteristics (ROC) with cut-off values for optimal sensitivity and specificity explored.Results: One hundred and four individuals were included prospectively. The median (range) cohort age was 65 (21-98) years. The majority were female (56/104; 54%). Thirty-six (35%) were diagnosed with infection in the first 72 h of admission. Overall, 44/104 (42%) individuals had microbiological investigations performed. Treatment was prescribed for 33/36 (92%) of infected individuals and 4/68 (6%) of those with no identifiable bacterial infection. Mean (SD) likelihood estimates for those with and without infection were significantly different. The infection group had a likelihood of 0.80 (0.09) and the non-infection group 0.50 (0.29) (P < 0.01; 95% CI: 0.20-0.40). ROC AUC was 0.84 (95% CI: 0.76-0.91).Conclusions: An SML algorithm was able to diagnose infection in individuals presenting to hospital using routinely available blood parameters. [ABSTRACT FROM AUTHOR]- Published
- 2019
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23. Behaviour change interventions to influence antimicrobial prescribing: a cross-sectional analysis of reports from UK state-of-the-art scientific conferences
- Author
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Rawson, T. M., primary, Moore, L. S. P., additional, Tivey, A. M., additional, Tsao, A., additional, Gilchrist, M., additional, Charani, E., additional, and Holmes, A. H., additional
- Published
- 2017
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24. Delivering precision antimicrobial therapy through closed-loop control systems.
- Author
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Rawson, T M, O'Hare, D, Herrero, P, Sharma, S, Moore, L S P, Barra, E de, Roberts, J A, Gordon, A C, Hope, W, Georgiou, P, de Barra, E, Cass, A E G, and Holmes, A H
- Subjects
ANTI-infective agents ,BIOSENSORS ,DRUG monitoring ,DRUG resistance in microorganisms ,ELECTROCHEMICAL analysis ,ENDOSCOPIC surgery ,HYPODERMIC needles ,DRUG development ,TREATMENT effectiveness ,ACCURACY - Abstract
Sub-optimal exposure to antimicrobial therapy is associated with poor patient outcomes and the development of antimicrobial resistance. Mechanisms for optimizing the concentration of a drug within the individual patient are under development. However, several barriers remain in realizing true individualization of therapy. These include problems with plasma drug sampling, availability of appropriate assays, and current mechanisms for dose adjustment. Biosensor technology offers a means of providing real-time monitoring of antimicrobials in a minimally invasive fashion. We report the potential for using microneedle biosensor technology as part of closed-loop control systems for the optimization of antimicrobial therapy in individual patients. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
25. Delivering precision antimicrobial therapy through closed-loop control systems.
- Author
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Rawson, T. M., O'Hare, D., Herrero, P., Sharma, S., Moore, L. S. P., de Barra, E., Roberts, J. A., Gordon, A. C., Hope, W., Georgiou, P., Cass, A. E. G., and Holmes, A. H.
- Subjects
ANTI-infective agents ,CLOSED loop systems ,DRUG resistance ,BIOSENSORS ,BIOLOGICAL assay - Abstract
Sub-optimal exposure to antimicrobial therapy is associated with poor patient outcomes and the development of antimicrobial resistance. Mechanisms for optimizing the concentration of a drug within the individual patient are under development. However, several barriers remain in realizing true individualization of therapy. These include problems with plasma drug sampling, availability of appropriate assays, and current mechanisms for dose adjustment. Biosensor technology offers a means of providing real-time monitoring of antimicrobials in a minimally invasive fashion. We report the potential for using microneedle biosensor technology as part of closed-loop control systems for the optimization of antimicrobial therapy in individual patients. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
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26. Exploring the epidemiology of carbapenem-resistant Gram-negative bacteria in west London and the utility of routinely collected hospital microbiology data
- Author
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Freeman, R., primary, Moore, L. S. P., additional, Charlett, A., additional, Donaldson, H., additional, and Holmes, A. H., additional
- Published
- 2014
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27. Homogeneity of antimicrobial policy, yet heterogeneity of antimicrobial resistance: antimicrobial non-susceptibility among 108 717 clinical isolates from primary, secondary and tertiary care patients in London
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Moore, L. S. P., primary, Freeman, R., additional, Gilchrist, M. J., additional, Gharbi, M., additional, Brannigan, E. T., additional, Donaldson, H., additional, Livermore, D. M., additional, and Holmes, A. H., additional
- Published
- 2014
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28. Community-acquired Klebsiella pneumoniae liver abscess: the London experience
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Moore, L. S. P., primary, Clarke, I. L., additional, Donaldson, H., additional, and Azadian, B., additional
- Published
- 2013
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29. An analysis of the development and implementation of a smartphone application for the delivery of antimicrobial prescribing policy: lessons learnt
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Charani, E., primary, Kyratsis, Y., additional, Lawson, W., additional, Wickens, H., additional, Brannigan, E. T., additional, Moore, L. S. P., additional, and Holmes, A. H., additional
- Published
- 2012
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30. Doctors taking a pulse using their mobile phone can spread MRSA
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Morris, T. C., primary, Moore, L. S. P., additional, and Shaunak, S., additional
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- 2012
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31. A report on a rare case of Klebsiella ozaenae causing atrophic rhinitis in the UK
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Lee, Y. J., primary, Moore, L. S. P., additional, and Almeyda, J., additional
- Published
- 2011
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32. Strengthening Undergraduate Social Work Research: Models and Strategies
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Moore, L. S., primary, Avant, F., additional, and Austin, S. F., additional
- Published
- 2008
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33. Charge Rearrangement and Screening in a Quantum Point Contact
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Lüscher, S., primary, Moore, L. S., additional, Rejec, T., additional, Meir, Yigal, additional, Shtrikman, Hadas, additional, and Goldhaber-Gordon, D., additional
- Published
- 2007
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34. Minimal inhibitory concentrations and minimal bactericidal concentrations of quinupristin/dalfopristin against clinical isolates of Corynebacterium jeikeium and Listeria monocytogenes
- Author
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Moore, L. S., primary, Schneider, B., additional, and Holloway, W. J., additional
- Published
- 1997
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35. Syndromic surveillance of surgical site infections--a case study in coronary artery bypass graft patients.
- Author
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King, C, Aylin, P, Moore, L S P, Pavlu, J, and Holmes, A
- Abstract
Objective: There is a wealth of data routinely collected and stored by healthcare facilities, which are not consistently exploited for surveillance of healthcare associated infections (HCAI). Syndromic surveillance has not yet been widely applied to HCAI. This study aimed to create syndromic surveillance for surgical site infections (SSI) following coronary artery bypass graft (CABG) procedures.Methods: A cohort of CABG patients from Imperial College Healthcare NHS Trust was investigated. Data from the local Patient Administration System, Laboratory Information Management System, radiology department, cardiac registry and Health Protection Agency SSI surveillance were linked. This data was explored for biological markers and proxies of infection, which were used to develop syndromic surveillance algorithms; sensitivity analysis was used to determine the best algorithms.Results: 303 patients were included, with a SSI incidence of 6.6%. Wound culture requests, raised platelet and fibrinogen levels were all found to be good indicators of SSI. Two algorithms were generated, one to detect all SSI (sensitivity: 90%; specificity: 93.8%) and one to detect organ space infections specifically (sensitivity: 100%; specificity: 98.5%).Conclusion: Data which is routinely collected and stored in healthcare facilities can be used for syndromic surveillance of SSI, allowing for an efficient surveillance system without the need for resource intensive data collection. [ABSTRACT FROM AUTHOR]- Published
- 2014
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36. Evidence for Clonal Spread of a Single Strain of -Lactamase-Producing Enterococcus (Streptococcus) faecalis to Six Hospitals in Five States
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Murray, B. E., primary, Singh, K. V., additional, Markowitz, S. M., additional, Lopardo, H. A., additional, Patterson, J. E., additional, Zervos, M. J., additional, Rubeglio, E., additional, Eliopoulos, G. M., additional, Rice, L. B., additional, Goldstein, F. W., additional, Jenkins, S. G., additional, Caputo, G. M., additional, Nasnas, R., additional, Moore, L. S., additional, Wong, E. S., additional, and Weinstock, G., additional
- Published
- 1991
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37. Comparison of Empirical Potential Functions and Molecular Orbital Calculations for Water Dimerization.
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Moore, L. S. and O'Connell, J. P.
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- 1971
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38. 1,3;1,3;2,3;2,3;-Tetra-μ-thio-1,2-bis(triphenylphosphine)digold(I)tungsten(VI).
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Pritchard, R. G., Moore, L. S., Parish, R. V., McAuliffe, C. A., and Beagley, B.
- Published
- 1988
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39. Exterior view of apartment buildings on West Sixth Street, Los Angeles, 1900
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Moore, L. S. and Moore, L. S.
- Subjects
- 1900, Los Angeles, 6th Street, California., United States., Californie., California., United States.
- Abstract
Photograph of an exterior view of apartment buildings on West Sixth Street, Los Angeles, 1900. Three identical two-story buildings can be seen in a line that runs from the foreground at center to the background at right. The buildings have two rows of wood-framed windows and all have flat roofs. Covered porches can be seen at right. Trees and a fire hydrant can be seen in the foreground near a concrete sidewalk.
- Published
- 1900
40. A needs assessment study for optimising prescribing practice in secondary care junior doctors: the Antibiotic Prescribing Education among Doctors (APED)
- Author
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Gharbi, M., Moore, L. S. P., Castro-Sanchez, E., Spanoudaki, E., Grady, C., Holmes, A. H., Drumright, L. N., British Society for Antimicrobial Chemotherapy, and National Institute for Health Research
- Subjects
RM ,Antimicrobials ,education ,1103 Clinical Sciences ,Continuing medical education ,Microbiology ,QR ,Clinical education ,Knowledge ,Infectious Diseases ,1108 Medical Microbiology ,Behaviour ,0605 Microbiology - Abstract
BACKGROUND: Appropriate antimicrobial prescribing is essential for patient care, yet up to half of antimicrobial prescriptions written in the UK are sub-optimal. Improving prescriber education has recently been promoted as a mechanism to optimise antimicrobial use, but identification of key learning objectives to facilitate this is so far lacking. Using qualitative methods we investigated junior doctor knowledge, attitudes, and behaviours around antimicrobial prescribing to identify key areas to address in future educational programmes. \ud \ud METHODS: A cross-sectional survey of qualified doctors in training in West London was undertaken exploring antimicrobial prescribing practices and educational needs. \ud \ud RESULTS: Among 140 junior doctors from 5 London hospitals, a third (34 %) reported prescribing primarily unsupervised, and two thirds (67 %) reported difficulties obtaining prescribing support outside of hours. 20 % stated not feeling confident in writing an antimicrobial prescription, but confidence was increased through having confirmatory diagnostic results (24) and obtaining advice from a senior doctor (26 %); whether this senior was from their own specialty, or an infection-specialist, varied significantly (p
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41. ChemInform Abstract: Triorganotin(IV) Benzoates and Aminobenzoates.
- Author
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SANDHU, G. K., primary, VERMA, S. P., additional, MOORE, L. S., additional, and PARISH, R. V., additional
- Published
- 1987
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42. ChemInform Abstract: Gold‐197 Moessbauer Spectra of Some Gold‐Ruthenium Cluster Compounds
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MOORE, L. S., primary, PARISH, R. V., additional, BROWN, S. S. D., additional, and SALTER, I. D., additional
- Published
- 1988
- Full Text
- View/download PDF
43. ChemInform Abstract: Studies of Iodine in Nitric Acid and of Iodine Adsorbed onto Silver-Impregnated Silica.
- Author
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BERRY, F. J., primary, COLLINS, R. D., additional, PARISH, R. V., additional, and MOORE, L. S., additional
- Published
- 1987
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44. ChemInform Abstract: 197Au Moessbauer Spectra of Complexes of Bis(diphenylphosphino)amine Containing Gold(I), Gold(II), and Gold(III).
- Author
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MOORE, L. S., primary, PARISH, R. V., additional, USON, R., additional, LAGUNA, A., additional, LAGUNA, M., additional, and NIEVES FRAILE, M., additional
- Published
- 1988
- Full Text
- View/download PDF
45. ChemInform Abstract: Gold-197 Moessbauer Spectra and the Bonding of Some Gold-Gold and Gold-Platinum Clusters.
- Author
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PARISH, R. V., primary, MOORE, L. S., additional, DENS, A. J. J., additional, MINGOS, D. M. P., additional, and SHERMAN, D. J., additional
- Published
- 1989
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- View/download PDF
46. ChemInform Abstract: An Iron‐57 and Gold‐197 Moessbauer Spectroscopic Investigation of the Bonding in Two Gold‐Iron Cluster Compounds.
- Author
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PARISH, R. V., primary, MOORE, L. S., additional, DENS, A. J. D., additional, MINGOS, D. M. P., additional, and SHERMAN, D. J., additional
- Published
- 1988
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47. ChemInform Abstract: Synthesis and Reactivity of Perchlorate Bis(tetrahydrothiophen)gold(I).
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USON, R., primary, LAGUNA, A., additional, NAVARRO, A., additional, PARISH, R. V., additional, and MOORE, L. S., additional
- Published
- 1986
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48. Intermolecular forces in gases of associating substances
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Moore, L. S., primary and O'Connell, J. P., additional
- Published
- 1972
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49. Missed opportunities for shared decision making in antimicrobial stewardship: The potential consequences of a lack of patient engagement in secondary care.
- Author
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Rawson, T. M., Moore, L. S. P., Hernandez, B., Castro-Sánchez, E., Charani, E., Ahmad, R., and Holmes, A. H.
- Subjects
- *
ANTI-infective agents , *MEDICAL decision making , *SECONDARY care (Medicine) , *COMMUNICABLE disease treatment , *HEALTH policy , *DRUG prescribing - Abstract
Background: Within infectious diseases in secondary care, understanding of the potential for behavioural changes arising from patient involvement in antimicrobial decision making is lacking. Shared decision making is becoming part of international policy. The United States have passed it into legislation and the United Kingdom has implemented a number of national interventions across healthcare pathways. This study aims to understand the level of patient involvement in decision making around antimicrobial use in secondary care and the potential consequences associated with it. Methods & Materials: Fourteen members of the public who had received antimicrobials from secondary care in the preceding 12 months were recruited to participate in group interviews. Group interactions were audio-recorded, transcribed verbatim, and thematically analysed. Results: Participants reported feelings of disempowerment during episodes of infection in secondary care. Information is currently communicated in a unilateral manner with individuals 'told' that they have an infection and will receive an antimicrobial (often unnamed), leading to loss of ownership, frustration, anxiety and ultimately distancing them from participation in decision making. This poor communication drives individuals to seek information from alternative sources, including on-line resources, which are associated with concerns over reliability and individualisation. This failure of communication and information provision from clinicians in secondary care influences individual's future ideas about infections and their management. This alters their future actions towards infections and antimicrobials and can drive non-adherence to prescribed antimicrobial regimes and loss-to-follow-up after discharge from secondary care. Conclusion: Current infection management and antimicrobial prescribing practices in secondary care may be failing to engage patients in the decision making process. It is vital that secondary care physicians do not view infection management episodes as discrete events, but as cumulative experiences which have the potential to drive future non-adherence to prescribed antimicrobial regimes and thus poor individual outcomes and antimicrobial resistance. This lesson is transferable to all settings of healthcare, where poor communication and information provision having the potential to influence future health seeking behaviours. We call for the development of clear, pragmatic mechanism to support healthcare professionals and patients engage in infection related decision making during consultations. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
50. Real time antimicrobial resistance surveillance in critical care: Identifying outbreaks of carbapenem resistant gram negative bacteria from routinely collected data.
- Author
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Moore, L. S. P., Freeman, R., Charlett, A., otter, J. A., Donaldson, H., and Holmes, A. H.
- Subjects
- *
CARBAPENEMS , *DRUG resistance in bacteria , *ANTI-infective agents , *CRITICAL care medicine , *DISEASE outbreaks , *ENTEROBACTERIACEAE - Abstract
Background: Statistically significant variation in antimicrobial resistance (AMR) occurs between hospitals, within hospitals, and over time. Whilst case mix and antimicrobial use contribute, the impact of cross-transmission on these fluctuations is not well understood. We investigated the utility of applying a statistical algorithm to identify outbreaks of carbapenem-resistant infections across three critical care units in a multi-centre teaching hospital network serving a population of 2 million in London, UK. Methods & Materials: We applied a negative binomial regression model which accounts for seasonality and linear trends, as described by Noufaily et al., to routinely collected microbiology data (fiscal years 2009-2015 for two units, 2012-2015 for the third) for carbapenem-resistant Pseudomonas spp. and Enterobacteriaceae (CRE). The first two years of data for each unit was used to train the algorithm. Exceedances (i.e. weeks with possible outbreaks) were validated by antibiogram comparison (as a proxy-indicator of strain similarity), against hospital infection control reports, and where available through genotypic typing. Results: Across the three units, 154 CRE (from 3640 Enterobacteriaceae) were identified. The algorithm identified 17 exceedance weeks, in 11 multi-week clusters. In four of these clusters (three K. pneumoniae, one E. coli) organisms shared identical antibiograms; typing was available for one K. pneumoniae cluster, indicating clonal NDM cross-transmission, and this was the only outbreak (of the 11 clusters) identified in hospital infection control reports. Among 786 carbapenem-resistant Pseudomonas spp. (from 2378 isolated), 27 exceedance weeks were detected, in 15 multi-week clusters. Organisms in eight clusters shared identical antibiograms. No typing was available and none of the clusters had been identified in hospital infection control reports. No additional outbreaks of CRE or carbapenem-resistant Pseudomonas spp. were identified through routine surveillance or in hospital infection control reports. Conclusion: The rise of carbapenem resistant organisms necessitates low-cost, easy-to-use surveillance mechanisms to aid early identification of outbreaks, particularly in critical care. Our data suggests such outbreaks may be more common than previously thought, and may be going undetected by current surveillance systems. Application of the Noufaily algorithm to routinely collected microbiology data provides a valid mechanism to better target limited hospital epidemiology, infection control, and diagnostics resources. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
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