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Your search keyword '"Moore, Kaitlin"' showing total 166 results
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166 results on '"Moore, Kaitlin"'

1. Demonstration of atom interrogation using photonic integrated circuits anodically bonded to ultra-high vacuum envelopes for epoxy-free scalable quantum sensors

Author

McBride, Sterling E., Gentry, Cale M., Holland, Christopher, Bellew, Colby, Moore, Kaitlin R., and Braun, Alan

Subjects
Quantum Physics, Physics - Applied Physics
Abstract

Reliable integration of photonic integrated circuits (PICs) into quantum sensors has the potential to drastically reduce sensor size, ease manufacturing scalability, and improve performance in applications where the sensor is subject to high accelerations, vibrations, and temperature changes. In a traditional quantum sensor assembly, free-space optics are subject to pointing inaccuracies and temperature-dependent misalignment. Moreover, the use of epoxy or sealants for affixing either free-space optics or PICs within a sensor vacuum envelope leads to sensor vacuum degradation and is difficult to scale. In this paper, we describe the hermetic integration of a PIC with a vacuum envelope via anodic bonding. We demonstrate utility of this assembly with two proof-of-concept atom-interrogation experiments: (1) spectroscopy of a cold-atom sample using a grating-emitted probe; (2) spectroscopy of alkali atoms using an evanescent field from an exposed ridge waveguide. This work shows a key process step on a path to quantum sensor manufacturing scalability, Comment: 8 pages, 7 figures

Published
2024

2. Independent Rydberg Atom Sensing using a Dual-Ladder Scheme

Author

Berweger, Samuel, Artusio-Glimpse, Alexandra B., Prajapati, Nikunjkumar, Rotunno, Andrew P., Schlossberger, Noah, Shylla, Dangka, Moore, Kaitlin R., Simons, Matthew T., and Holloway, Christopher L.

Subjects
Physics - Atomic Physics
Abstract

Rydberg atom-based electric field sensing can provide all-optical readout of radio frequency fields in a dielectric environment. However, because a single set of optical fields is typically used to prepare the Rydberg state and read out its response to RF fields, it is challenging to perform simultaneous and independent measurements of the RF field(s). Here we show that using two independent schemes to prepare and read out the same Rydberg state can be used to perform independent measurements in general, which we demonstrate specifically by resolving the the RF polarization. We expect this work will be useful for fiber-coupled sensor heads where spatial multiplexing is challenging, as well as for complex multi-level sensing schemes.

Published
2024

3. Phase-Resolved Rydberg Atom Field Sensing using Quantum Interferometry

Author

Berweger, Samuel, Artusio-Glimpse, Alexandra B., Rotunno, Andrew P., Prajapati, Nikunjkumar, Christesen, Joseph D., Moore, Kaitlin R., Simons, Matthew T., and Holloway, Christopher L.

Subjects
Physics - Atomic Physics
Abstract

Although Rydberg atom-based electric field sensing provides key advantages over traditional antenna-based detection, it remains limited by the need for a local oscillator (LO) for low-field and phase resolved detection. In this work, we demonstrate that closed-loop quantum interferometric schemes can be used to generate a system-internal reference that can directly replace an external LO for Rydberg field sensing. We reveal that this quantum-interferometrically defined internal reference phase and frequency can be used analogously to a traditional LO for atom-based down-mixing to an intermediate frequency for lock-in phase detection. We demonstrate that this LO-equivalent functionality provides analogous benefits to an LO, including full 360$^\circ$ phase resolution as well as improved sensitivity. The general applicability of this approach is confirmed by demodulating a four phase-state signal broadcast on the atoms. Our approach opens up new sensing schemes and provides a clear path towards all-optical Rydberg atom sensing implementations.

Published
2022

6. A human breast atlas integrating single-cell proteomics and transcriptomics

Author

Gray, G Kenneth, Li, Carman Man-Chung, Rosenbluth, Jennifer M, Selfors, Laura M, Girnius, Nomeda, Lin, Jia-Ren, Schackmann, Ron CJ, Goh, Walter L, Moore, Kaitlin, Shapiro, Hana K, Mei, Shaolin, D'Andrea, Kurt, Nathanson, Katherine L, Sorger, Peter K, Santagata, Sandro, Regev, Aviv, Garber, Judy E, Dillon, Deborah A, and Brugge, Joan S

Subjects
Biochemistry and Cell Biology, Biological Sciences, Breast Cancer, Cancer, Human Genome, Genetics, Aging, Biotechnology, Underpinning research, 1.1 Normal biological development and functioning, Aetiology, 2.1 Biological and endogenous factors, Animals, Breast, Breast Neoplasms, Female, Humans, Mammary Glands, Animal, Pregnancy, Proteomics, Transcriptome, BRCA1, BRCA2, CyTOF mass cytometry, aging, breast cancer, cell state plasticity, mammary biology, multi-omic single-cell atlas, multiplexed tissue staining, organoids, scRNA-Seq, Medical and Health Sciences, Developmental Biology, Biochemistry and cell biology
Abstract

The breast is a dynamic organ whose response to physiological and pathophysiological conditions alters its disease susceptibility, yet the specific effects of these clinical variables on cell state remain poorly annotated. We present a unified, high-resolution breast atlas by integrating single-cell RNA-seq, mass cytometry, and cyclic immunofluorescence, encompassing a myriad of states. We define cell subtypes within the alveolar, hormone-sensing, and basal epithelial lineages, delineating associations of several subtypes with cancer risk factors, including age, parity, and BRCA2 germline mutation. Of particular interest is a subset of alveolar cells termed basal-luminal (BL) cells, which exhibit poor transcriptional lineage fidelity, accumulate with age, and carry a gene signature associated with basal-like breast cancer. We further utilize a medium-depletion approach to identify molecular factors regulating cell-subtype proportion in organoids. Together, these data are a rich resource to elucidate diverse mammary cell states.

Published
2022

8. Enhanced observation time of magneto-optical traps using micro-machined non-evaporable getter pumps

Author

Boudot, Rodolphe, McGilligan, James P., Moore, Kaitlin R., Maurice, Vincent, Martinez, Gabriela D., Hansen, Azure, de Clercq, Emeric, and Kitching, John

Subjects
Physics - Atomic Physics
Abstract

We show that micro-machined non-evaporable getter pumps (NEGs) can extend the time over which laser cooled atoms canbe produced in a magneto-optical trap (MOT), in the absence of other vacuum pumping mechanisms. In a first study, weincorporate a silicon-glass microfabricated ultra-high vacuum (UHV) cell with silicon etched NEG cavities and alumino-silicateglass (ASG) windows and demonstrate the observation of a repeatedly-loading MOT over a 10 minute period with a single laser-activated NEG. In a second study, the capacity of passive pumping with laser activated NEG materials is further investigated ina borosilicate glass-blown cuvette cell containing five NEG tablets. In this cell, the MOT remained visible for over 4 days withoutany external active pumping system. This MOT observation time exceeds the one obtained in the no-NEG scenario by almostfive orders of magnitude. The cell scalability and potential vacuum longevity made possible with NEG materials may enable inthe future the development of miniaturized cold-atom instruments., Comment: 9 pages, 5 figures

Published
2020

9. Cardiac radiation improves ventricular function in mice and humans with cardiomyopathy

Author

Pedersen, Lauren N., Valenzuela Ripoll, Carla, Ozcan, Mualla, Guo, Zhen, Lotfinaghsh, Aynaz, Zhang, Shiyang, Ng, Sherwin, Weinheimer, Carla, Nigro, Jessica, Kovacs, Attila, Diab, Ahmed, Klaas, Amanda, Grogan, Felicia, Cho, Yoonje, Ataran, Anahita, Luehmann, Hannah, Heck, Abigail, Kolb, Kollin, Strong, Lori, Navara, Rachita, Walls, Gerard M., Hugo, Geoff, Samson, Pamela, Cooper, Daniel, Reynoso, Francisco J., Schwarz, Julie K., Moore, Kaitlin, Lavine, Kory, Rentschler, Stacey L., Liu, Yongjian, Woodard, Pamela K., Robinson, Clifford, Cuculich, Phillip S., Bergom, Carmen, and Javaheri, Ali

Published
2023
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11. Measuring the Rydberg Constant Using Circular Rydberg Atoms in an Intensity-Modulated Optical Lattice

Author

Ramos, Andira, Moore, Kaitlin, and Raithel, Georg

Subjects
Physics - Atomic Physics
Abstract

A method for performing a precision measurement of the Rydberg constant, $R_{\infty}$, using cold circular Rydberg atoms is proposed. These states have long lifetimes, as well as negligible quantum-electrodynamics (QED) and no nuclear-overlap corrections. Due to these advantages, the measurement can help solve the "proton radius puzzle" [Bernauer, Pohl, Sci. Am. 310, 32 (2014)]. The atoms are trapped using a Rydberg-atom optical lattice, and transitions are driven using a recently-demonstrated lattice-modulation technique to perform Doppler-free spectroscopy. The circular-state transition frequency yields $R_{\infty}$. Laser wavelengths and beam geometries are selected such that the lattice-induced transition shift is minimized. The selected transitions have no first-order Zeeman and Stark corrections, leaving only manageable second-order Zeeman and Stark shifts. For Rb, the projected relative uncertainty of $R_{\infty}$ in a measurement under the presence of the Earth's gravity is $10^{-11}$, with the main contribution coming from the residual lattice shift. This could be reduced in a future micro-gravity implementation. The next-important systematic arises from the Rb$^+$ polarizability (relative-uncertainty contribution of $\approx 3 \times10^{-12}$).

Published
2017
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12. Developing a data repository to support interdisciplinary research into childhood stunting: a UKRI GCRF Action Against Stunting Hub protocol paper

Author

Conway-Moore, Kaitlin, primary, Tetsa Tata, Darius, additional, Wood, Peter, additional, Katerinchuk, Val, additional, Yadav, D M Dinesh, additional, Augustine, Little Flower, additional, Munikumar, Manne, additional, Diop, Assana, additional, Tairou, Fassiatou, additional, Jobarteh, Modou Lamin, additional, Kulkarni, Bharati, additional, Faye, Babacar, additional, Haggarty, Paul, additional, and Heffernan, Claire, additional

Published
2024
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13. Nonlinear and magic ponderomotive spectroscopy

Author

Moore, Kaitlin and Raithel, Georg

Subjects
Physics - Atomic Physics
Abstract

In ponderomotive spectroscopy an amplitude-modulated optical standing wave is employed to probe Rydberg-atom transitions, utilizing a ponderomotive rather than a dipole-field interaction. Here, we engage nonlinearities in the modulation to drive dipole-forbidden transitions up to the fifth order. We reach transition frequencies approaching the sub-THz regime. We also demonstrate magic-wavelength conditions, which result in symmetric spectral lines with a Fourier-limited feature at the line center. Applicability to precision measurement is discussed., Comment: 5 pages, 6 figures, 1 table

Published
2015

15. Independent Rydberg atom sensing using a dual-ladder scheme

Author

Berweger, Samuel, primary, Artusio-Glimpse, Alexandra B., additional, Prajapati, Nikunjkumar, additional, Rotunno, Andrew P., additional, Schlossberger, Noah, additional, Shylla, Dangka, additional, Moore, Kaitlin R., additional, Simons, Matthew T., additional, and Holloway, Christopher L., additional

Published
2024
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16. Forbidden atomic transitions driven by an intensity-modulated laser trap

Author

Moore, Kaitlin R., Anderson, Sarah E., and Raithel, Georg

Subjects
Physics - Atomic Physics
Abstract

Spectroscopy is an essential tool in understanding and manipulating quantum systems, such as atoms and molecules. The model describing spectroscopy includes a multipole-field interaction, which leads to established spectroscopic selection rules, and an interaction that is quadratic in the field, which is often neglected. However, spectroscopy using the quadratic (ponderomotive) interaction promises two significant advantages over spectroscopy using the multipole-field interaction: flexible transition rules and vastly improved spatial addressability of the quantum system. For the first time, we demonstrate ponderomotive spectroscopy by using optical-lattice-trapped Rydberg atoms, pulsating the lattice light at a microwave frequency, and driving a microwave atomic transition that would otherwise be forbidden by established spectroscopic selection rules. This new ability to measure frequencies of previously inaccessible transitions makes possible improved determinations of atomic characteristics and constants underlying physics. In the spatial domain, the resolution of ponderomotive spectroscopy is orders of magnitude better than the transition frequency (and the corresponding diffraction limit) would suggest, promising single-site addressability in a dense particle array for quantum control and computing applications. Future advances in technology may allow ponderomotive spectroscopy to be extended to ground-state atoms and trapped molecules., Comment: Main manuscript, 19 pages; 5 figures; Supplementary information, 5 pages

Published
2014
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21. Co‐creating obesity prevention policies with youth: Policy ideas generated through the CO‐CREATE project

Author

Conway‐Moore, Kaitlin, primary, Knai, Cécile, additional, Finegood, Diane, additional, Johnston, Lee, additional, Brinsden, Hannah, additional, Aguiar, Anaely, additional, Kopainsky, Birgit, additional, Önal, Furkan, additional, Helleve, Arnfinn, additional, Klepp, Knut‐Inge, additional, Lien, Nanna, additional, Luszczynska, Aleksandra, additional, Rito, Ana Isabel, additional, Rønnestad, Alfred Mestad, additional, Ulstein, Madeleine, additional, Blanchard, Laurence, additional, Savona, Natalie, additional, and Rutter, Harry, additional

Published
2023
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22. Learning from the CO‐CREATE project: A protocol for systems thinking across research (STAR)

Author

Knai, Cécile, primary, Savona, Natalie, additional, Finegood, Diane, additional, Aguiar, Anaely, additional, Blanchard, Laurence, additional, Conway‐Moore, Kaitlin, additional, Helleve, Arnfinn, additional, Klepp, Knut‐Inge, additional, Lien, Nanna, additional, Luszczynska, Aleksandra, additional, Vlad, Ioana, additional, Rønnestad, Alfred Mestad, additional, and Rutter, Harry, additional

Published
2023
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26. LB-456090-3 LONG-TERM RESULTS FROM A PROSPECTIVE PHASE 1/2 TRIAL OF ELECTROPHYSIOLOGY-GUIDED NONINVASIVE CARDIAC RADIOABLATION FOR VENTRICULAR TACHYCARDIA

Author

Cuculich, Phillip, primary, Moore, Kaitlin, additional, Cooper, Daniel H., additional, Faddis, Mitchell N., additional, Ghadban, Rugheed, additional, Smith, Timothy W., additional, Sodhi, Sandeep S., additional, Samson, Pamela, additional, Zhang, Shiyang, additional, Wiener, Philip C., additional, Hugo, Geoffrey, additional, Knutson, Nels, additional, and Robinson, Cliff, additional

Published
2023
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27. PO-05-104 FEASIBILITY STUDY OF SINGLE DAY SIMULATION- FREE CARDIAC RADIOABLATION WORKFLOW WITH A PORCINE MODEL

Author

Knutson, Nels, primary, Mazur, Thomas, additional, Zhao, Tianyu, additional, Prusator, Michael, additional, Hugo, Geoffrey, additional, Beckert, Robbie, additional, Moore, Kaitlin, additional, Samson, Pamela, additional, Rentschler, Stacey, additional, Schwarz, Julie, additional, Cuculich, Phillip, additional, Bergom, Carmen, additional, Pavek, Todd, additional, Zemlin, Christian, additional, and Robinson, Cliff, additional

Published
2023
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28. PO-05-064 UTILITY OF CATHETER ABLATION VT RISK SCORES IN PREDICTING OUTCOMES FOLLOWING CARDIAC RADIOABLATION FOR HIGH-RISK REFRACTORY VT

Author

Robinson, Cliff, primary, Samson, Pamela, additional, Contreras, Carlos, additional, Moore, Kaitlin, additional, Rentschler, Stacey, additional, Schwarz, Julie, additional, Bergom, Carmen, additional, Knutson, Nels, additional, Prusator, Michael, additional, Hugo, Geoffrey, additional, and Cuculich, Phillip, additional

Published
2023
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29. Abstract PD5-02: PD5-02 An Organoid Model System to Study Resistance Mechanisms, Predictive Biomarkers, and New Strategies to Overcome Therapeutic Resistance in Early-Stage Triple-Negative Breast Cancer

Author

Bui, Tam Binh V., primary, Wolf, Denise M., additional, Moore, Kaitlin, additional, Harris, Isaac S., additional, Phadatare, Pravin, additional, Yau, Christina, additional, Swigart, Lamorna A. Brown, additional, Esserman, Laura J., additional, Coppe, Jean-Philippe, additional, Wulfkuhle, Julia, additional, Petricoin, Emanuel F., additional, Campbell, Michael, additional, Selfors, Laura M., additional, Dillon, Deborah A., additional, Overmoyer, Beth, additional, Lynce, Filipa, additional, Van ’t Veer, Laura, additional, and Rosenbluth, Jennifer, additional

Published
2023
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32. Cultivating Change: Disseminating Innovation in Higher Education Teaching and Learning

Author

Gannaway, Deanne, Hinton, Tilly, Berry, Bianca, and Moore, Kaitlin

Abstract

Effective dissemination is crucial if innovation and development in teaching and learning in higher education are to lead to sustainable changes in practice. In 2003, King used an agricultural metaphor to challenge innovators to understand the purposes behind their dissemination aims. Similar to the way that seed can be spread, one could choose to widely scatter the information, and hope it grows wherever it lands; one could actively direct the scattering; or one could nurture and propagate future adoption in an ongoing manner. A recent investigation into dissemination strategies used in Australian teaching and learning innovation grants shows that certain dissemination strategies might make the ground more fertile and receptive to the seeds sown. To those engaged in funded projects grappling with translating project outputs and outcomes to sustainable changes in practice, this paper offers a framework and tools designed to help prepare the soil and cultivate change.

Published
2013
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45. Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing

Author

Massachusetts Institute of Technology. Department of Biology, Li, Carman Man-Chung, Shapiro, Hana, Tsiobikas, Christina, Selfors, Laura M, Chen, Huidong, Rosenbluth, Jennifer, Moore, Kaitlin, Gupta, Kushali P, Gray, G Kenneth, Oren, Yaara, Steinbaugh, Michael J, Guerriero, Jennifer L, Pinello, Luca, Regev, Aviv, Brugge, Joan S, Massachusetts Institute of Technology. Department of Biology, Li, Carman Man-Chung, Shapiro, Hana, Tsiobikas, Christina, Selfors, Laura M, Chen, Huidong, Rosenbluth, Jennifer, Moore, Kaitlin, Gupta, Kushali P, Gray, G Kenneth, Oren, Yaara, Steinbaugh, Michael J, Guerriero, Jennifer L, Pinello, Luca, Regev, Aviv, and Brugge, Joan S

Abstract

© 2020 The Author(s) Aging is closely associated with increased susceptibility to breast cancer, yet there have been limited systematic studies of aging-induced alterations in the mammary gland. Here, we leverage high-throughput single-cell RNA sequencing to generate a detailed transcriptomic atlas of young and aged murine mammary tissues. By analyzing epithelial, stromal, and immune cells, we identify age-dependent alterations in cell proportions and gene expression, providing evidence that suggests alveolar maturation and physiological decline. The analysis also uncovers potential pro-tumorigenic mechanisms coupled to the age-associated loss of tumor suppressor function and change in microenvironment. In addition, we identify a rare, age-dependent luminal population co-expressing hormone-sensing and secretory-alveolar lineage markers, as well as two macrophage populations expressing distinct gene signatures, underscoring the complex heterogeneity of the mammary epithelia and stroma. Collectively, this rich single-cell atlas reveals the effects of aging on mammary physiology and can serve as a useful resource for understanding aging-associated cancer risk.

Published
2021

47. Abstract PD7-03: A living biobank of normal mammary organoids derived from patients at low and increased risk of developing breast cancer

Author

Rosenbluth, Jennifer M, primary, Li, Carman Man-Chung, additional, Gray, Kenneth G, additional, Gao, Walter, additional, Schackmann, Ron CJ, additional, Zoeller, Jason J, additional, Selfors, Laura M, additional, Moore, Kaitlin, additional, Dillon, Deborah, additional, Garber, Judy, additional, and Brugge, Joan S, additional

Published
2021
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49. Flow-induced Shear Stress Confers Resistance to Carboplatin in an Adherent Three-Dimensional Model for Ovarian Cancer: A Role for EGFR-Targeted Photoimmunotherapy Informed by Physical Stress

Author

Nath, Shubhankar, primary, Pigula, Michael, additional, Khan, Amjad P., additional, Hanna, William, additional, Ruhi, Mustafa Kemal, additional, Dehkordy, Farzaneh Mahmoodpoor, additional, Pushpavanam, Karthik, additional, Rege, Kaushal, additional, Moore, Kaitlin, additional, Tsujita, Yujiro, additional, Conrad, Christina, additional, Inci, Fatih, additional, del Carmen, Marcela G., additional, Franco, Walfre, additional, Celli, Jonathan P., additional, Demirci, Utkan, additional, Hasan, Tayyaba, additional, Huang, Huang-Chiao, additional, and Rizvi, Imran, additional

Published
2020
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50. Flow-induced Shear Stress Confers Resistance to Carboplatin in an Adherent Three-Dimensional Model for Ovarian Cancer: A Role for EGFR-Targeted Photoimmunotherapy Informed by Physical Stress

Author

Nath, Shubhankar, Nath, Shubhankar, Pigula, Michael, Khan, Amjad P., Hanna, William, Ruhi, Mustafa Kemal, Dehkordy, Farzaneh Mahmoodpoor, Pushpavanam, Karthik, Rege, Kaushal, Moore, Kaitlin, Tsujita, Yujiro, Conrad, Christina, Inci, Faith, del Carmen, Marcela G., Franco, Walfre, Celli, Jonathan P., Demirci, Utkan, Hasan, Tayyaba, Huang, Huang-Chiao, Rizvi, Imran, Nath, Shubhankar, Nath, Shubhankar, Pigula, Michael, Khan, Amjad P., Hanna, William, Ruhi, Mustafa Kemal, Dehkordy, Farzaneh Mahmoodpoor, Pushpavanam, Karthik, Rege, Kaushal, Moore, Kaitlin, Tsujita, Yujiro, Conrad, Christina, Inci, Faith, del Carmen, Marcela G., Franco, Walfre, Celli, Jonathan P., Demirci, Utkan, Hasan, Tayyaba, Huang, Huang-Chiao, and Rizvi, Imran

Abstract

A key reason for the persistently grim statistics associated with metastatic ovarian cancer is resistance to conventional agents, including platinum-based chemotherapies. A major source of treatment failure is the high degree of genetic and molecular heterogeneity, which results from significant underlying genomic instability, as well as stromal and physical cues in the microenvironment. Ovarian cancer commonly disseminates via transcoelomic routes to distant sites, which is associated with the frequent production of malignant ascites, as well as the poorest prognosis. In addition to providing a cell and protein-rich environment for cancer growth and progression, ascitic fluid also confers physical stress on tumors. An understudied area in ovarian cancer research is the impact of fluid shear stress on treatment failure. Here, we investigate the effect of fluid shear stress on response to platinum-based chemotherapy and the modulation of molecular pathways associated with aggressive disease in a perfusion model for adherent 3D ovarian cancer nodules. Resistance to carboplatin is observed under flow with a concomitant increase in the expression and activation of the epidermal growth factor receptor (EGFR) as well as downstream signaling members mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK) and extracellular signal-regulated kinase (ERK). The uptake of platinum by the 3D ovarian cancer nodules was significantly higher in flow cultures compared to static cultures. A downregulation of phospho-focal adhesion kinase (p-FAK), vinculin, and phospho-paxillin was observed following carboplatin treatment in both flow and static cultures. Interestingly, low-dose anti-EGFR photoimmunotherapy (PIT), a targeted photochemical modality, was found to be equally effective in ovarian tumors grown under flow and static conditions. These findings highlight the need to further develop PIT-based combinations that target the EGFR, and sensitize ovarian cancers

Published
2020

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