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1,008 results on '"Moore, Francis D"'

5. Supplementary Data from Galectin-3 Targeted Therapy with a Small Molecule Inhibitor Activates Apoptosis and Enhances Both Chemosensitivity and Radiosensitivity in Papillary Thyroid Cancer

Author

Lin, Chi-Iou, primary, Whang, Edward E., primary, Donner, David B., primary, Jiang, Xiaofeng, primary, Price, Brendan D., primary, Carothers, Adelaide M., primary, Delaine, Tamara, primary, Leffler, Hakon, primary, Nilsson, Ulf J., primary, Nose, Vania, primary, Moore,, Francis D., primary, and Ruan, Daniel T., primary

Published
2023
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6. Supplementary Figures from Genomic Heterogeneity and Exceptional Response to Dual Pathway Inhibition in Anaplastic Thyroid Cancer

Author

Gibson, William J., primary, Ruan, Daniel T., primary, Paulson, Vera A., primary, Barletta, Justine A., primary, Hanna, Glenn J., primary, Kraft, Stefan, primary, Calles, Antonio, primary, Nehs, Matthew A., primary, Moore, Francis D., primary, Taylor-Weiner, Amaro, primary, Wala, Jeremiah A., primary, Zack, Travis I., primary, Lee, Thomas C., primary, Fennessy, Fiona M., primary, Alexander, Erik K., primary, Thomas, Tom, primary, Janne, Pasi A., primary, Garraway, Levi A., primary, Carter, Scott L., primary, Beroukhim, Rameen, primary, Lorch, Jochen H., primary, and Van Allen, Eliezer M., primary

Published
2023
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9. Differential Growth Rates of Benign vs. Malignant Thyroid Nodules

Author

Angell, Trevor E, Vyas, Chirag M, Medici, Marco, Wang, Zhihong, Barletta, Justine A, Benson, Carol B, Cibas, Edmund S, Cho, Nancy L, Doherty, Gerard M, Doubilet, Peter M, Frates, Mary C, Gawande, Atul A, Heller, Howard T, Kim, Matthew I, Krane, Jeffrey F, Marqusee, Ellen, Moore, Francis D, Jr., Nehs, Matt A, Zavacki, Ann Marie, Larsen, P Reed, and Alexander, Erik K

Published
2017
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17. Inhibition of rat gut reperfusion injury with an agent developed for the mouse. Evidence that amplification of injury by innate immunity is conserved between two animal species

Author

Afnan, Jalil, Ahmadi-Yazdi, Cyrus, Sheu, Eric G., Oakes, Sean M., and Moore, Francis D., Jr.

Subjects
Immunoglobulins -- Physiological aspects, Immunoglobulins -- Research, Mice -- Usage, Mice -- Models, Reperfusion injury -- Risk factors, Reperfusion injury -- Research, Biological sciences
Abstract

Murine reperfusion injury follows binding of specific IgM natural antibodies to neo-antigens exposed in ischemic tissue. Peptides that mimic the site of antibody binding in the injury prevent IgM binding when administered intravenously before reperfusion. To determine whether this pathogenic sequence is restricted to mice, we have tested the ability of the peptide to prevent reperfusion injury in a dissimilar species, the rat. Sprague-Dawley rats were subjected to 40 min of mesenteric ischemia followed by 180 min of reperfusion. The peptide mimic was administered intravenously prior to reperfusion. Gut injury was quantified using a scoring system based on the hematoxylin-and-eosin section. [sup.125]I-labeled albumin was used to assess local (gut) and remote (lung) injury. The macroscopic appearance of bowel from peptide-treated animals was less edematous and hemorrhagic. Microscopic analysis showed a significantly reduced injury score in peptide-treated animals. Permeability data indicated a significant reduction in local and remote injury in peptide-treated animals. The data demonstrate attenuation of rat gut microvillus injury, of gut edema, and of remote injury following mesenteric ischemia-reperfusion due to administration of an intravenous peptide mimic of a murine ischemia neo-antigen, indicating a second species uses a similar ischemia neo-antigen and corresponding natural antibody specificity to amplify reperfusion injury to the point of necrosis. This mechanism of inflammation is potentially applicable to higher species. ischemia/reperfusion injury doi: 10.1152/ajpregu.00380.2009.

Published
2010

18. How Are Childhood Thyroid Nodules Discovered: Opportunities for Improving Early Detection

Author

Gupta, Anjuli, Ly, Samantha, Castroneves, Luciana A., Frates, Mary C., Benson, Carol B., Feldman, Henry A., Wassner, Ari J., Smith, Jessica R., Marqusee, Ellen, Alexander, Erik K., Barletta, Justine, Muyide, Funmilayo, Doubilet, Peter M., Peters, Hope E., Webb, Susan, Modi, Biren P., Paltiel, Harriet J., Martins, Yolanda, Burmeister, Kelly, Kozakewich, Harry, Hollowell, Monica, Cibas, Edmund S., Moore, Francis D., Jr, Shamberger, Robert C., Larsen, Reed P., and Huang, Stephen A.

Published
2014
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21. Long-term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluation

Author

Yassa, Leila, Cibas, Edmund C., Benson, Carol B., Frates, Mary C., Doubilet, Peter M., Gawande, Atul A., Moore, Francis D., Kim, Brian W., Nose, Vania, Marqusee, Ellen, Larsen, P. Reed, and Alexander, Erik K.

Subjects
Thyroid diseases -- Diagnosis, Thyroid diseases -- Research, Biopsy, Needle -- Methods, Biopsy, Needle -- Usage, Biopsy, Needle -- Research, Diagnosis, Ultrasonic -- Usage, Diagnosis, Ultrasonic -- Research, Health
Published
2007

22. Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injury

Author

Zhang, Ming, Austen, William G., Jr., Chiu, Isaac, Alicot, Elisabeth M., Hung, Rachel, Ma, Minghe, Verna, Nicola, Xu, Min, Hechtman, Herbert B., Moore, Francis D., Jr., and Carroll, Michael C.

Subjects
Viral antibodies -- Research, Antibodies -- Research, Science and technology
Abstract

Reperfusion injury of ischemic tissue represents an acute inflammatory response that can cause significant morbidity and mortality. The mechanism of injury is not fully elucidated, but recent studies indicate an important role for natural antibody and the classical pathway of complement. To test the hypothesis that injury is initiated by specific IgM, we have screened a panel of IgM-producing hybridomas prepared from peritoneal cells enriched in B-1 cells. One clone, CM22, was identified that could restore pathogenic injury in RAG-[1.sup.-/-] mice in an intestinal model of ischemia/reperfusion (I/R), In situ activation of the classical pathway of complement was evident by deposition of IgM, complement C4, and C3 in damaged tissue after passive transfer of CM22 IgM. Sequence analysis of CM22 Ig heavy and light chains showed germ-line configurations with high homology to a [V.sub.H] sequence from the B-1 repertoire and a [V.sub.K] of a known polyreactive natural IgM. These data provide definitive evidence that I/R injury can be initiated by clonally specific natural IgM that activates the classical pathway of complement. This finding opens an avenue for identification of I/R-specific self-antigen(s) and early prevention of injury.

Published
2004

23. A Standardized Assessment of Thyroid Nodules in Children Confirms Higher Cancer Prevalence Than in Adults

Author

Gupta, Anjuli, Ly, Samantha, Castroneves, Luciana A., Frates, Mary C., Benson, Carol B., Feldman, Henry A., Wassner, Ari J., Smith, Jessica R., Marqusee, Ellen, Alexander, Erik K., Barletta, Justine, Doubilet, Peter M., Peters, Hope E., Webb, Susan, Modi, Biren P., Paltiel, Harriet J., Kozakewich, Harry, Cibas, Edmund S., Moore, Francis D., Jr, Shamberger, Robert C., Larsen, P. Reed, and Huang, Stephen A.

Published
2013

24. Thyroid Nodule Size and Prediction of Cancer

Author

Kamran, Sophia C., Marqusee, Ellen, Kim, Mathew I., Frates, Mary C., Ritner, Julie, Peters, Hope, Benson, Carol B., Doubilet, Peter M., Cibas, Edmund S., Barletta, Justine, Cho, Nancy, Gawande, Atul, Ruan, Daniel, Moore, Francis D., Jr, Pou, Karla, Larsen, P. Reed, and Alexander, Erik K.

Published
2013

29. Sialyl [Lewis.sup.x] hybridized complement receptor type 1 moderates acid aspiration injury

Author

Kyriakides, Constantinos, Wang, Yong, Austen, William G., Jr., Favuzza, Joanne, Kobzik, Lester, Moore, Francis D., Jr., and Hechtman, Herbert B.

Subjects
Aspiration pneumonia -- Physiological aspects, Tracheotomy -- Physiological aspects, Airway (Medicine) -- Physiological aspects, Biological sciences
Abstract

Kyriakides, Constantinos, Yong Wang, William G. Austen, Jr., Joanne Favuzza, Lester Kobzik, Francis D. Moore, Jr., and Herbert B. Hechtman. Sialyl [Lewis.sup.x] hybridized complement receptor type 1 moderates acid aspiration injury. Am J Physiol Lung Cell Mol Physiol 281: L1494-L1499, 2001.--The potentially enhanced anti-inflammatory effects of the sialyl [Lewis.sup.x] (s[Le.sup.x])-decorated version of soluble complement receptor type 1 (sCR1) in moderating acid aspiration injury are examined. HCl was instilled in tracheostomy tubes placed in mice, and extravasation of [sup.125.I]-labeled albumin in bronchoalveolar lavage (BAL) fluid was used to calculate the vascular permeability index (PI). Neutrophil counts in BAL fluid and immunohistochemistry were performed. PI was moderated by 82% after treatment with sCR1s[Le.sup.x] compared with 54% in sCR1-untreated mice (P < 0.05). Respective reductions in PI in mice treated 0.5 and 1 h after acid aspiration with sCR1s[Le.sup.x] of 70 and 57% were greater than the decreases in PI of 45 and 38% observed in respective sCR1-treated groups (P < 0.05). BAL fluid neutrophil counts in sCR1s[Le.sup.x]-treated mice were significantly less than those in sCR1-treated animals, which were similar to those in untreated mice. Immunohistochemistry stained for sCR1 only on the pulmonary vascular endothelium of sCR1s[Le.sup.x]- but not sCR1-treated mice. In conclusion, sCR1s[Le.sup.x] moderates permeability by antagonizing complement activation and neutrophil adhesion. Delayed complement and neutrophil antagonism significantly reduces injury. pneumonia; murine; inflammation; complement activation; selectins

Published
2001

31. Preoperative basal calcitonin and tumor stage correlate with postoperative calcitonin normalization in patients undergoing initial surgical management of medullary thyroid carcinoma

Author

Yip, Dana T., Hassan, Maria, Pazaitou-Panayiotou, Kalliopi, Ruan, Daniel T., Gawande, Atul A., Gaz, Randall D., Moore, Francis D., Jr., Hodin, Richard A., Stephen, Antonia E., Sadow, Peter M., Daniels, Gilbert H., Randolph, Gregory W., Parangi, Sareh, and Lubitz, Carrie C.

Published
2011
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35. Completion Thyroidectomy is Less Common Following Updated 2015 American Thyroid Association Guidelines

Author

Kuo, Lindsay E., primary, Angell, Trevor E., additional, Pandian, T. K., additional, Moore, Alessandra L., additional, Alexander, Erik K., additional, Barletta, Justine A., additional, Gawande, Atul A., additional, Lorch, Jochen H., additional, Marqusee, Ellen, additional, Moore, Francis D., additional, Nehs, Matthew A., additional, Doherty, Gerard M., additional, and Cho, Nancy L., additional

Published
2020
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50. Alpha1-acid glycoprotein reduces local and remote injuries after intestinal ischemia in the rat

Author

Williams, Julian P., Weiser, Martin R., Pechet, Taine T.V., Kobzik, Les, Moore, Francis D., Jr., and Hechtman, Herbert B.

Subjects
Glycoproteins -- Physiological aspects, Intestines -- Injuries, Intestinal ischemia -- Care and treatment, Rats -- Physiological aspects, Neutrophils -- Physiological aspects, Complement (Immunology) -- Physiological aspects, Biological sciences
Abstract

The antineutrophil and anticomplement effects of alpha1-acid glycoprotein on intestinal ischemia in rats were investigated. A purified recombinant form of sialyl Lewisx-bearing alpha1-acid glycoprotein (sAGP) was used in an experiment to test whether its administration would reduce remote lung and liver injuries in rats. Results showed that sAGP indeed limited remote organ injury, ischemia-reperfusion-induced changes in intestinal permeability and complement deposition. It did not, however, reduce systemic complement activity. sAGP was revealed to be localized to sites of injury.

Published
1997

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