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188 results on '"Moore, D. T."'

3. Study of electronic properties of perovskite materials and their interfaces with extracting layers in lateral heterojunction configuration

Author

Sean Dunfield, Stefania Cacovich, Davide Regaldo, Jean Baptiste Puel, Mathieu Frégnaux, Klein, T., Bramante, R., Zhang, F., Teeter, G., Luther, J. M., Nordlund, D., Zhu, K., Moore, D. T., Hest, M. F. A. M., Jean-Paul Kleider, Berry, J. J., Philip Schulz, National Renewable Energy Laboratory (NREL), University of Colorado [Boulder], Institut Photovoltaïque d’Ile-de-France (UMR) (IPVF), École polytechnique (X)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-TOTAL FINA ELF-EDF (EDF)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Photovoltaïque d’Ile-de-France (ITE) (IPVF)-Air Liquide [Siège Social], Institut Photovoltaïque d'Ile-de-France (IPVF), Laboratoire Génie électrique et électronique de Paris (GeePs), CentraleSupélec-Sorbonne Université (SU)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), EDF R&D (EDF R&D), EDF (EDF), Institut Lavoisier de Versailles (ILV), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), SLAC National Accelerator Laboratory (SLAC), Stanford University, and KLEIDER, Jean-Paul

Subjects
[SPI.OPTI] Engineering Sciences [physics]/Optics / Photonic, [SPI.NANO] Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, [SPI.NRJ]Engineering Sciences [physics]/Electric power, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, [SPI.MAT] Engineering Sciences [physics]/Materials, [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, [PHYS.COND.CM-MS] Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], ComputingMilieux_MISCELLANEOUS, [SPI.NRJ] Engineering Sciences [physics]/Electric power, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract

National audience

Published
2021

5. Structures of HCN-Mgn (n=2–6) complexes from rotationally resolved vibrational spectroscopy and ab initio theory.

Author

Stiles, P. L., Moore, D. T., and Miller, R. E.

Subjects
*INFRARED spectroscopy, *DIPOLE moments, *MOLECULES, *DIELECTRICS, *SPECTRUM analysis, *MAGNESIUM, *PHYSICAL & theoretical chemistry
Abstract

High-resolution infrared laser spectroscopy has been used to determine the structures of HCN-Mgn complexes formed in helium nanodroplets. The magnesium atoms are first added to the droplets to ensure that the magnesium complexes are preformed before the HCN molecule is added. The vibrational frequencies, structures, and dipole moments of these complexes are found to vary dramatically with cluster size, illustrating the nonadditive nature of the HCN-magnesium interactions. All of the complexes discussed here have the nitrogen end of the HCN pointing towards the magnesium clusters. For Mg3, the HCN binds to the “threefold” site, yielding a symmetric top spectrum. Although the HCN-Mg4 complex also has C3v symmetry, the HCN sits “on-top” of a single magnesium atom. These structures are confirmed by both ab initio calculations and measurements of the dipole moments. Significant charge transfer is observed in the case of HCN-Mg4, indicative of charge donation from the lone pair on the nitrogen of HCN into the lowest unoccupied molecular orbital of the Mg4. © 2004 American Institute of Physics. [ABSTRACT FROM AUTHOR]

Published
2004
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6. Infrared spectroscopy of the isomers of magnesium–HCN formed in helium nanodroplets: Comparisons with ab initio calculations.

Author

Stiles, P. L., Moore, D. T., and Miller, R. E.

Subjects
*INFRARED spectroscopy, *MAGNESIUM, *HELIUM, *MOLECULES, *DIPOLE moments
Abstract

High-resolution infrared spectra are reported for two isomers of the magnesium-HCN binary complex, corresponding to the magnesium bonding at the nitrogen and hydrogen ends of the molecule. Stark spectra are also reported for these complexes, from which the corresponding dipole moments are determined. Ab initio calculations confirm that the potential energy surface has two minima, consistent with the experimentally determined structures. The wave functions of the two dimensional intermolecular coupled cluster singles doubles (triples) potential energy surface, calculated with the collocation method, are also reported for the magnesium-HCN system and are used to calculate the vibrationally averaged dipole moment for both isomers, which are then compared to experiment. [ABSTRACT FROM AUTHOR]

Published
2003
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7. Solvation of HF by molecular hydrogen: Helium nanodroplet vibrational spectroscopy

Author

Moore, D. T., Miller, R. E., Kumazaki, Shigeichi, Yoshihara, Keitaro, Mitsuo, Kira, and Naohiko, Mikami

Subjects
Coumarins -- Research, Coumarins -- Atomic properties, Vibrational spectra -- Usage, Hydrogen bonding -- Atomic properties, Helium -- Research, Helium -- Atomic properties, Chemicals, plastics and rubber industries
Abstract

The low temperatures and high resolution associated with helium droplet spectroscopy are used to obtain vibrational spectra for clusters containing a single HF molecule. The results suggest that, for n=9 and larger, the solvent cage becomes highly isotropic allowing the HF molecule to undergo nearly free rotation.

Published
2003

8. A Randomized Phase II Study of Carboplatin With Weekly or Every-3-Week Nanoparticle Albumin-Bound Paclitaxel (Abraxane) in Patients With Extensive-Stage Small Cell Lung Cancer

Author

Socinski, M. A., Keedy, V. L., Moore, D. T., Sandler, A., Stinchcombe, T. E., and Grilley-Olson, J. E.

Subjects
endocrine system diseases, neoplasms, female genital diseases and pregnancy complications
Abstract

Platinum plus etoposide is the standard therapy for extensive-stage small cell lung cancer (ES-SCLC) and is associated with significant myelosuppression. We hypothesized that the combination of carboplatin and nanoparticle albumin-bound paclitaxel (nab-paclitaxel) would be better tolerated. We investigated carboplatin with nab-paclitaxel on every-3-week and weekly schedules.

Published
2015
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9. Epstein-Barr Virus-Encoded Latent Membrane Protein 1 (LMP1) and LMP2A Function Cooperatively To Promote Carcinoma Development in a Mouse Carcinogenesis Model

Author

Moore, D. T., Bendt, K. M., Shair, K. H. Y., Edwards, R. H., Nielsen, J. N., and Raab-Traub, N.

Subjects
stomatognathic diseases, otorhinolaryngologic diseases
Abstract

The Epstein-Barr virus (EBV) proteins latent membrane proteins 1 and 2 (LMP1 and LMP2) are frequently expressed in EBV-associated lymphoid and epithelial cancers and have complex effects on cell signaling and growth. The effects of these proteins on epithelial cell growth were assessed in vivo using transgenic mice driven by the keratin 14 promoter (K14). The development of papillomas and carcinomas was determined in the tumor initiator and promoter model using dimethyl benzanthracene (DMBA), followed by repeated treatments of 12-O-tetradecanoyl phorbol 13-acetate (TPA). In these assays, LMP1 functioned as a weak tumor promoter and increased papilloma formation. In contrast, mice expressing LMP2A did not induce or promote papilloma formation. Transgenic LMP1 mice had slightly increased development of squamous cell carcinoma; however, the development of carcinoma was significantly increased in the doubly transgenic mice expressing both LMP1 and LMP2A. DMBA treatment induces an activating mutation in the Harvey-ras (H-ras61) oncogene, and this mutation was identified in most papillomas and carcinomas although several papillomas and carcinomas in K14-LMP1 and K14-LMP1/LMP2A mice lacked the mutation. Analysis of signaling pathways that are known to be activated by LMP1 and/or LMP2 indicated that all genotypes had high levels of activated extracellular signal-regulated kinase (ERK) and Stat3 in carcinomas with significantly higher activation in the doubly transgenic carcinomas. These findings suggest that, in combination, LMP1 and LMP2 contribute to carcinoma progression and that this may reflect the combined effects of the proteins on activation of multiple signaling pathways. This study is the first to characterize the effects of LMP2 on tumor initiation and promotion and to identify an effect of the combined expression of LMP1 and LMP2 on the increase of carcinoma development.

Published
2012
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10. Potential Selection of LMP1 Variants in Nasopharyngeal Carcinoma

Author

Edwards, R. H., Sitki-Green, D., Moore, D. T., and Raab-Traub, N.

Subjects
stomatognathic diseases, otorhinolaryngologic diseases
Abstract

Seven distinct sequence variants of the Epstein-Barr virus latent membrane protein 1 (LMP1) have been identified by distinguishing amino acid changes in the carboxy-terminal domain. In this study the transmembrane domains are shown to segregate identically with the distinct carboxy-terminal amino acid sequences. Since strains of LMP1 have been shown to differ in abundance between blood and throat washes, nasopharyngeal carcinomas (NPCs) from areas of endemicity and nonendemicity with matching blood were analyzed by using a heteroduplex tracking assay to distinguish LMP1 variants. Striking differences were found between the compartments with the Ch1 strain prevalent in the NPCs from areas of endemicity and nonendemicity and the B958 strain prevalent in the blood of the endemic samples, whereas multiple strains of LMP1 were prevalent in the blood of the nonendemic samples. The possible selection against the B958 strain appearing in the tumor was highly significant (P < 0.0001). Sequence analysis of the full-length LMP1 variants revealed changes in many of the known and computer-predicted HLA-restricted epitopes with changes in key positions in multiple, potential epitopes for the specific HLA of the patients. These amino acid substitutions at key positions in the LMP1 epitopes may result in a reduced cytotoxic-T-lymphocyte response. These data indicate that strains with specific variants of LMP1 are more likely to be found in NPC. The predominance of specific LMP1 variants in NPC could reflect differences in the biologic or molecular properties of the distinct forms of LMP1 or possible immune selection.

Published
2004
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11. Phase I/II trial of bevacizumab (B) and erlotinib (E) with induction (IND) and concurrent (CON) carboplatin (Cb)/paclitaxel (P) and 74 Gy of thoracic conformal radiotherapy (TCRT) in stage III non-small cell lung cancer (NSCLC).

Author

Stinchcombe, T., primary, Socinski, M. A., additional, Moore, D. T., additional, Gettinger, S. N., additional, Decker, R. H., additional, Petty, W. J., additional, Blackstock, A. W., additional, Schwartz, G., additional, Lankford, S., additional, and Morris, D. E., additional

Published
2011
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13. Phase II study and tissue correlative studies of AZD6244 (ARRY-142886) in iodine-131 refractory papillary thyroid carcinoma (IRPTC) and papillary thyroid carcinoma (PTC) with follicular elements.

Author

Lucas, A. S., primary, Cohen, E. E., additional, Cohen, R. B., additional, Krzyzanowska, M. K., additional, Chung, C. H., additional, Murphy, B. A., additional, Tanvetyanon, T., additional, Gilbert, J., additional, Moore, D. T., additional, and Hayes, D. N., additional

Published
2010
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14. Preliminary results of a randomized phase II trial of first-line treatment of gemcitabine (G) versus erlotinib (E) versus gemcitabine and erlotinib (GE) in patients 70 years or older with advanced non-small cell lung cancer (NSCLC).

Author

Stinchcombe, T., primary, Bradford, D. S., additional, Lee, C. B., additional, Moore, D. T., additional, Bakri, K. M., additional, Taylor, M. A., additional, Crane, J. M., additional, Schwartz, G., additional, Hensing, T. A., additional, and Socinski, M. A., additional

Published
2010
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15. Molecular Stratification of Clear Cell Renal Cell Carcinoma by Consensus Clustering Reveals Distinct Subtypes and Survival Patterns

Author

Brannon, A. R., primary, Reddy, A., additional, Seiler, M., additional, Arreola, A., additional, Moore, D. T., additional, Pruthi, R. S., additional, Wallen, E. M., additional, Nielsen, M. E., additional, Liu, H., additional, Nathanson, K. L., additional, Ljungberg, B., additional, Zhao, H., additional, Brooks, J. D., additional, Ganesan, S., additional, Bhanot, G., additional, and Rathmell, W. K., additional

Published
2010
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17. Incorporation of bevacizumab (B) and erlotinib (Er) with induction (Ind) and concurrent (Conc) carboplatin (Cb)/paclitaxel (P) and 74 Gy of thoracic radiotherapy in stage III non-small cell lung cancer (NSCLC)

Author

Socinski, M. A., primary, Stinchcombe, T. E., additional, Halle, J. S., additional, Moore, D. T., additional, Petty, W. J., additional, Blackstock, A. W., additional, Gettinger, S. N., additional, Decker, R. H., additional, Khandani, A. H., additional, and Morris, D. E., additional

Published
2009
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19. Rectangular Luneburg-type lenses for integrated optics

Author

Wood, V. E, Busch, J. R, Moore, D. T, Wooley, C. B, and Southwell, W. H

Subjects
Optics
Abstract

Compact Luneburg-type lenses of rectangular outline as viewed from above have been made by thermal evaporation of As2S3 glass onto single-mode LiNbO3:Ti waveguides through suitably shaped masks and subsequent exposure of the glass to ultraviolet light. The best lenses had speeds of f/5.5 at an aperture of 10 mm and focal spots at reduced aperture about 1.2 times the diffraction-limited size. These lenses have a field of view of at least 25 degrees inside the waveguide.

Published
1983

20. Incorporation of bevacizumab (B) and erlotinib (Er) with induction (I) and concurrent (C) carboplatin (Cb)/paclitaxel (P) and 74 Gy of thoracic radiotherapy in stage III non-small cell lung cancer (NSCLC)

Author

Socinski, M. A., primary, Morris, D. E., additional, Stinchcombe, T. E., additional, Halle, J. S., additional, Moore, D. T., additional, Tynan, M. T., additional, Siegel, M. A., additional, Petty, W. J., additional, Blackstock, A. W., additional, Khandani, A. H., additional, and Rosenman, J. G., additional

Published
2008
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