Search

Your search keyword '"Moore, Andrew S."' showing total 432 results
Start Over Author "Moore, Andrew S."
432 results on '"Moore, Andrew S."'

5. Late effects in survivors of infant acute lymphoblastic leukaemia—a study of the Australian and New Zealand Children’s Haematology/Oncology Group

Author

Mironova, Denitza, Saraswati, Chitra M., Downie, Peter, Lai, Chow Yee, Cook, Eleanor, Carruthers, Vickyanne, Moukhaiber, Perla, Molloy, Fiona, Serov, Joshua, McKinnon, Elizabeth, Alvaro, Frank, Osborn, Michael, Revesz, Tamas, Prestidge, Tim, Cross, Siobhan, Bateman, Caroline M., Moore, Andrew S., Khaw, Seong Lin, Mateos, Marion K., and Kotecha, Rishi S.

Published
2023
Full Text
View/download PDF

6. A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer

Author

Mayoh, Chelsea, Gifford, Andrew J., Terry, Rachael, Lau, Loretta M. S., Wong, Marie, Rao, Padmashree, Shai-Hee, Tyler, Saletta, Federica, Khuong-Quang, Dong-Anh, Qin, Vicky, Mateos, Marion K., Meyran, Deborah, Miller, Katherine E., Yuksel, Aysen, Mould, Emily V. A., Bowen-James, Rachel, Govender, Dinisha, Senapati, Akanksha, Zhukova, Nataliya, Omer, Natacha, Dholaria, Hetal, Alvaro, Frank, Tapp, Heather, Diamond, Yonatan, Pozza, Luciano Dalla, Moore, Andrew S., Nicholls, Wayne, Gottardo, Nicholas G., McCowage, Geoffrey, Hansford, Jordan R., Khaw, Seong-Lin, Wood, Paul J., Catchpoole, Daniel, Cottrell, Catherine E., Mardis, Elaine R., Marshall, Glenn M., Tyrrell, Vanessa, Haber, Michelle, Ziegler, David S., Vittorio, Orazio, Trapani, Joseph A., Cowley, Mark J., Neeson, Paul J., and Ekert, Paul G.

Published
2023
Full Text
View/download PDF

7. Adhesion-mediated mechanosignaling forces mitohormesis

Author

Tharp, Kevin M, Higuchi-Sanabria, Ryo, Timblin, Greg A, Ford, Breanna, Garzon-Coral, Carlos, Schneider, Catherine, Muncie, Jonathon M, Stashko, Connor, Daniele, Joseph R, Moore, Andrew S, Frankino, Phillip A, Homentcovschi, Stefan, Manoli, Sagar S, Shao, Hao, Richards, Alicia L, Chen, Kuei-Ho, Hoeve, Johanna Ten, Ku, Gregory M, Hellerstein, Marc, Nomura, Daniel K, Saijo, Karou, Gestwicki, Jason, Dunn, Alexander R, Krogan, Nevan J, Swaney, Danielle L, Dillin, Andrew, and Weaver, Valerie M

Subjects
Biochemistry and Cell Biology, Biological Sciences, Cancer, Aging, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Adult, Animals, Animals, Genetically Modified, Caenorhabditis elegans, Cell Adhesion, Cell Respiration, Cells, Cultured, Extracellular Matrix, Female, HEK293 Cells, Humans, Hyperglycemia, Integrins, Ion Exchange, Mechanotransduction, Cellular, Mice, Microscopy, Confocal, Middle Aged, Mitochondria, Mitochondrial Dynamics, Oxidative Stress, Reactive Oxygen Species, Signal Transduction, Sodium-Hydrogen Exchanger 1, Time-Lapse Imaging, UPRmt, adhesion, aging, cancer, extracellular matrix, mechanical stress, mechanotabolism, metabolism, oxidative stress, tension, Medical Biochemistry and Metabolomics, Endocrinology & Metabolism, Biochemistry and cell biology, Medical biochemistry and metabolomics
Abstract

Mitochondria control eukaryotic cell fate by producing the energy needed to support life and the signals required to execute programed cell death. The biochemical milieu is known to affect mitochondrial function and contribute to the dysfunctional mitochondrial phenotypes implicated in cancer and the morbidities of aging. However, the physical characteristics of the extracellular matrix are also altered in cancerous and aging tissues. Here, we demonstrate that cells sense the physical properties of the extracellular matrix and activate a mitochondrial stress response that adaptively tunes mitochondrial function via solute carrier family 9 member A1-dependent ion exchange and heat shock factor 1-dependent transcription. Overall, our data indicate that adhesion-mediated mechanosignaling may play an unappreciated role in the altered mitochondrial functions observed in aging and cancer.

Published
2021

8. Circular RNAs drive oncogenic chromosomal translocations within the MLL recombinome in leukemia

Author

Conn, Vanessa M., Gabryelska, Marta, Toubia, John, Kirk, Kirsty, Gantley, Laura, Powell, Jason A., Cildir, Gökhan, Marri, Shashikanth, Liu, Ryan, Stringer, Brett W., Townley, Scott, Webb, Stuart T., Lin, He, Samaraweera, Saumya E., Bailey, Sheree, Moore, Andrew S., Maybury, Mellissa, Liu, Dawei, Colella, Alex D., Chataway, Timothy, Wallington-Gates, Craig T., Walters, Lucie, Sibbons, Jane, Selth, Luke A., Tergaonkar, Vinay, D’Andrea, Richard J., Pitson, Stuart M., Goodall, Gregory J., and Conn, Simon J.

Published
2023
Full Text
View/download PDF

9. Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma

Author

Nobre, Liana, Zapotocky, Michal, Khan, Sara, Fukuoka, Kohei, Fonseca, Adriana, McKeown, Tara, Sumerauer, David, Vicha, Ales, Grajkowska, Wieslawa A, Trubicka, Joanna, Li, Kay Ka Wai, Ng, Ho-Keung, Massimi, Luca, Lee, Ji Yeoun, Kim, Seung-Ki, Zelcer, Shayna, Vasiljevic, Alexandre, Faure-Conter, Cécile, Hauser, Peter, Lach, Boleslaw, van Veelen-Vincent, Marie-Lise, French, Pim J, Van Meir, Erwin G, Weiss, William A, Gupta, Nalin, Pollack, Ian F, Hamilton, Ronald L, Rao, Amulya A Nageswara, Giannini, Caterina, Rubin, Joshua B, Moore, Andrew S, Chambless, Lola B, Vibhakar, Rajeev, Ra, Young Shin, Massimino, Maura, McLendon, Roger E, Wheeler, Helen, Zollo, Massimo, Ferruci, Veronica, Kumabe, Toshihiro, Faria, Claudia C, Sterba, Jaroslav, Jung, Shin, López-Aguilar, Enrique, Mora, Jaume, Carlotti, Carlos G, Olson, James M, Leary, Sarah, Cain, Jason, Krskova, Lenka, Zamecnik, Josef, Hawkins, Cynthia E, Tabori, Uri, Huang, Annie, Bartels, Ute, Northcott, Paul A, Taylor, Michael D, Yip, Stephen, Hansford, Jordan R, Bouffet, Eric, and Ramaswamy, Vijay

Subjects
Cancer, Clinical Research, Evaluation of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Adolescent, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Cerebellar Neoplasms, Child, Cyclophosphamide, Female, Humans, Ifosfamide, Male, Medulloblastoma, Middle Aged, Neoplasm Recurrence, Local, Progression-Free Survival, medulloblastoma, WNT, genomics, cyclophosphamide, chemotherapy, prognosis, survival
Abstract

Over the past decade, wingless-activated (WNT) medulloblastoma has been identified as a candidate for therapy de-escalation based on excellent survival; however, a paucity of relapses has precluded additional analyses of markers of relapse. To address this gap in knowledge, an international cohort of 93 molecularly confirmed WNT MB was assembled, where 5-year progression-free survival is 0.84 (95%, 0.763-0.925) with 15 relapsed individuals identified. Maintenance chemotherapy is identified as a strong predictor of relapse, with individuals receiving high doses of cyclophosphamide or ifosphamide having only one very late molecularly confirmed relapse (p = 0.032). The anatomical location of recurrence is metastatic in 12 of 15 relapses, with 8 of 12 metastatic relapses in the lateral ventricles. Maintenance chemotherapy, specifically cumulative cyclophosphamide doses, is a significant predictor of relapse across WNT MB. Future efforts to de-escalate therapy need to carefully consider not only the radiation dose but also the chemotherapy regimen and the propensity for metastatic relapses.

Published
2020

10. Measurable residual disease analysis in paediatric acute lymphoblastic leukaemia patients with ABL-class fusions

Author

Venn, Nicola C., Huang, Libby, Hovorková, Lenka, Muskovic, Walter, Wong, Marie, Law, Tamara, Heatley, Susan L., Khaw, Seong Lin, Revesz, Tom, Dalla Pozza, Luciano, Shaw, Peter J., Fraser, Chris, Moore, Andrew S., Cross, Siobhan, Bendak, Katerina, Norris, Murray D., Henderson, Michelle J., White, Deborah L., Cowley, Mark J., Trahair, Toby N., Zuna, Jan, and Sutton, Rosemary

Published
2022
Full Text
View/download PDF

11. Precision-guided treatment in high-risk pediatric cancers

Author

Lau, Loretta M. S., primary, Khuong-Quang, Dong-Anh, additional, Mayoh, Chelsea, additional, Wong, Marie, additional, Barahona, Paulette, additional, Ajuyah, Pamela, additional, Senapati, Akanksha, additional, Nagabushan, Sumanth, additional, Sherstyuk, Alexandra, additional, Altekoester, Ann-Kristin, additional, Fuentes-Bolanos, Noemi A., additional, Yeung, Veronica, additional, Sullivan, Ashleigh, additional, Omer, Natacha, additional, Diamond, Yonatan, additional, Jessop, Sophie, additional, Battaglia, Lauren, additional, Zhukova, Nataliya, additional, Cui, Louise, additional, Lin, Angela, additional, Gifford, Andrew J., additional, Fleuren, Emmy D. G., additional, Dalla-Pozza, Luciano, additional, Moore, Andrew S., additional, Khaw, Seong-Lin, additional, Eisenstat, David D., additional, Gottardo, Nicholas G., additional, Wood, Paul J., additional, Tapp, Heather, additional, Alvaro, Frank, additional, McCowage, Geoffrey, additional, Nicholls, Wayne, additional, Hansford, Jordan R., additional, Manoharan, Neevika, additional, Kotecha, Rishi S., additional, Mateos, Marion K., additional, Lock, Richard B., additional, Tyrrell, Vanessa, additional, Haber, Michelle, additional, Trahair, Toby N., additional, Cowley, Mark J., additional, Ekert, Paul G., additional, Marshall, Glenn M., additional, and Ziegler, David S., additional

Published
2024
Full Text
View/download PDF

13. Intertumoral Heterogeneity within Medulloblastoma Subgroups

Author

Cavalli, Florence MG, Remke, Marc, Rampasek, Ladislav, Peacock, John, Shih, David JH, Luu, Betty, Garzia, Livia, Torchia, Jonathon, Nor, Carolina, Morrissy, A Sorana, Agnihotri, Sameer, Thompson, Yuan Yao, Kuzan-Fischer, Claudia M, Farooq, Hamza, Isaev, Keren, Daniels, Craig, Cho, Byung-Kyu, Kim, Seung-Ki, Wang, Kyu-Chang, Lee, Ji Yeoun, Grajkowska, Wieslawa A, Perek-Polnik, Marta, Vasiljevic, Alexandre, Faure-Conter, Cecile, Jouvet, Anne, Giannini, Caterina, Rao, Amulya A Nageswara, Li, Kay Ka Wai, Ng, Ho-Keung, Eberhart, Charles G, Pollack, Ian F, Hamilton, Ronald L, Gillespie, G Yancey, Olson, James M, Leary, Sarah, Weiss, William A, Lach, Boleslaw, Chambless, Lola B, Thompson, Reid C, Cooper, Michael K, Vibhakar, Rajeev, Hauser, Peter, van Veelen, Marie-Lise C, Kros, Johan M, French, Pim J, Ra, Young Shin, Kumabe, Toshihiro, López-Aguilar, Enrique, Zitterbart, Karel, Sterba, Jaroslav, Finocchiaro, Gaetano, Massimino, Maura, Van Meir, Erwin G, Osuka, Satoru, Shofuda, Tomoko, Klekner, Almos, Zollo, Massimo, Leonard, Jeffrey R, Rubin, Joshua B, Jabado, Nada, Albrecht, Steffen, Mora, Jaume, Van Meter, Timothy E, Jung, Shin, Moore, Andrew S, Hallahan, Andrew R, Chan, Jennifer A, Tirapelli, Daniela PC, Carlotti, Carlos G, Fouladi, Maryam, Pimentel, José, Faria, Claudia C, Saad, Ali G, Massimi, Luca, Liau, Linda M, Wheeler, Helen, Nakamura, Hideo, Elbabaa, Samer K, Perezpeña-Diazconti, Mario, de León, Fernando Chico Ponce, Robinson, Shenandoah, Zapotocky, Michal, Lassaletta, Alvaro, Huang, Annie, Hawkins, Cynthia E, Tabori, Uri, Bouffet, Eric, Bartels, Ute, Dirks, Peter B, Rutka, James T, Bader, Gary D, Reimand, Jüri, Goldenberg, Anna, Ramaswamy, Vijay, and Taylor, Michael D

Subjects
Genetics, Rare Diseases, Pediatric Cancer, Cancer, Brain Cancer, Pediatric Research Initiative, Pediatric, Human Genome, Brain Disorders, Cluster Analysis, Cohort Studies, DNA Copy Number Variations, DNA Methylation, Gene Expression Profiling, Genomics, Humans, Medulloblastoma, Precision Medicine, copy number, gene expression, integrative clustering, medulloblastoma, methylation, subgroups, Neurosciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma. Integrative analysis using SNF further delineates group 3 from group 4 medulloblastoma, which is not as readily apparent through analyses of individual data types. Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes and biology are identified. Medulloblastoma subtypes identified through integrative clustering have important implications for stratification of future clinical trials.

Published
2017

14. Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

Author

Torchia, Jonathon, Golbourn, Brian, Feng, Shengrui, Ho, Ching, Sin-Chan, Patrick, Vasiljevic, Alexandre, Norman, Joseph D, Guilhamon, Paul, Garzia, Livia, Agamez, Natalia R, Lu, Mei, Chan, Tiffany S, Picard, Daniel, de Antonellis, Pasqualino, Khuong-Quang, Dong-Anh, Planello, Aline C, Zeller, Constanze, Barsyte-Lovejoy, Dalia, Lafay-Cousin, Lucie, Letourneau, Louis, Bourgey, Mathieu, Yu, Man, Gendoo, Deena MA, Dzamba, Misko, Barszczyk, Mark, Medina, Tiago, Riemenschneider, Alexandra N, Morrissy, A Sorana, Ra, Young-Shin, Ramaswamy, Vijay, Remke, Marc, Dunham, Christopher P, Yip, Stephen, Ng, Ho-keung, Lu, Jian-Qiang, Mehta, Vivek, Albrecht, Steffen, Pimentel, Jose, Chan, Jennifer A, Somers, Gino R, Faria, Claudia C, Roque, Lucia, Fouladi, Maryam, Hoffman, Lindsey M, Moore, Andrew S, Wang, Yin, Choi, Seung Ah, Hansford, Jordan R, Catchpoole, Daniel, Birks, Diane K, Foreman, Nicholas K, Strother, Doug, Klekner, Almos, Bognár, Laszló, Garami, Miklós, Hauser, Péter, Hortobágyi, Tibor, Wilson, Beverly, Hukin, Juliette, Carret, Anne-Sophie, Van Meter, Timothy E, Hwang, Eugene I, Gajjar, Amar, Chiou, Shih-Hwa, Nakamura, Hideo, Toledano, Helen, Fried, Iris, Fults, Daniel, Wataya, Takafumi, Fryer, Chris, Eisenstat, David D, Scheinemann, Katrin, Fleming, Adam J, Johnston, Donna L, Michaud, Jean, Zelcer, Shayna, Hammond, Robert, Afzal, Samina, Ramsay, David A, Sirachainan, Nongnuch, Hongeng, Suradej, Larbcharoensub, Noppadol, Grundy, Richard G, Lulla, Rishi R, Fangusaro, Jason R, Druker, Harriet, Bartels, Ute, Grant, Ronald, Malkin, David, McGlade, C Jane, Nicolaides, Theodore, Tihan, Tarik, Phillips, Joanna, Majewski, Jacek, Montpetit, Alexandre, Bourque, Guillaume, Bader, Gary D, Reddy, Alyssa T, Gillespie, G Yancey, and Warmuth-Metz, Monika

Subjects
Genetics, Human Genome, Rare Diseases, Orphan Drug, Cancer, 2.1 Biological and endogenous factors, Development of treatments and therapeutic interventions, Aetiology, 5.1 Pharmaceuticals, Cell Line, Tumor, Cell Proliferation, Cell Survival, Central Nervous System Neoplasms, Chromatin, DNA Methylation, Dasatinib, Epigenesis, Genetic, Epigenomics, Humans, Mutation, Protein Kinase Inhibitors, Pyrimidines, Receptor, Platelet-Derived Growth Factor beta, Rhabdoid Tumor, SMARCB1 Protein, Teratoma, ATRT, enhancer, epigenomics, genomics, rhabdoid tumors, subgroup-specific therapeutics, Neurosciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we analyzed 191 primary ATRTs and 10 ATRT cell lines to define the genomic and epigenomic landscape of ATRTs and identify subgroup-specific therapeutic targets. We found ATRTs segregated into three epigenetic subgroups with distinct genomic profiles, SMARCB1 genotypes, and chromatin landscape that correlated with differential cellular responses to a panel of signaling and epigenetic inhibitors. Significantly, we discovered that differential methylation of a PDGFRB-associated enhancer confers specific sensitivity of group 2 ATRT cells to dasatinib and nilotinib, and suggest that these are promising therapies for this highly lethal ATRT subtype.

Published
2016

15. Actin cables and comet tails organize mitochondrial networks in mitosis

Author

Moore, Andrew S., Coscia, Stephen M., Simpson, Cory L., Ortega, Fabian E., Wait, Eric C., Heddleston, John M., and Nirschl, Jeffrey J.

Subjects
Mitosis -- Physiological aspects, Actin -- Structure, Mitochondria -- Distribution, Company distribution practices, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Symmetric cell division requires the even partitioning of genetic information and cytoplasmic contents between daughter cells. Whereas the mechanisms coordinating the segregation of the genome are well known, the processes that ensure organelle segregation between daughter cells remain less well understood.sup.1. Here we identify multiple actin assemblies with distinct but complementary roles in mitochondrial organization and inheritance in mitosis. First, we find a dense meshwork of subcortical actin cables assembled throughout the mitotic cytoplasm. This network scaffolds the endoplasmic reticulum and organizes three-dimensional mitochondrial positioning to ensure the equal segregation of mitochondrial mass at cytokinesis. Second, we identify a dynamic wave of actin filaments reversibly assembling on the surface of mitochondria during mitosis. Mitochondria sampled by this wave are enveloped within actin clouds that can spontaneously break symmetry to form elongated comet tails. Mitochondrial comet tails promote randomly directed bursts of movement that shuffle mitochondrial position within the mother cell to randomize inheritance of healthy and damaged mitochondria between daughter cells. Thus, parallel mechanisms mediated by the actin cytoskeleton ensure both equal and random inheritance of mitochondria in symmetrically dividing cells. During mitosis, complementary actin-based mechanisms ensure equal and random distributions of mitochondria among daughter cells following symmetrical cell division., Author(s): Andrew S. Moore [sup.1] [sup.2] [sup.3] , Stephen M. Coscia [sup.1] [sup.2] [sup.4] , Cory L. Simpson [sup.1] [sup.2] [sup.5] , Fabian E. Ortega [sup.6] , Eric C. Wait [...]

Published
2021
Full Text
View/download PDF

17. The physical and cellular mechanism of structural color change in zebrafish.

Author

Dvir Gur, Moore, Andrew S., Deis, Rachael, Pang Song, Xufeng Wu, Pinkas, Iddo, Deo, Claire, Iyer, Nirmala, Hess, Harald F., Hammer, John A., and Lippincott-Schwartz, Jennifer

Subjects
*STRUCTURAL colors, *FOCUSED ion beams, *BRACHYDANIO, *OPTICAL interference, *MICROSCOPY
Abstract

Many animals exhibit remarkable colors that are produced by the constructive interference of light reflected from arrays of intracellular guanine crystals. These animals can fine-tune their crystal-based structural colors to communicate with each other, regulate body temperature, and create camouflage. While it is known that these changes in color are caused by changes in the angle of the crystal arrays relative to incident light, the cellular machinery that drives color change is not understood. Here, using a combination of 3D focused ion beam scanning electron microscopy (FIB-SEM), micro-focused X-ray diffraction, superresolution fluorescence light microscopy, and pharmacological perturbations, we characterized the dynamics and 3D cellular reorganization of crystal arrays within zebrafish iridophores during norepinephrine (NE)-induced color change. We found that color change results from a coordinated 20° tilting of the intracellular crystals, which alters both crystal packing and the angle at which impinging light hits the crystals. Importantly, addition of the dynein inhibitor dynapyrazole-a completely blocked this NE-induced red shift by hindering crystal dynamics upon NE addition. FIB-SEM and microtubule organizing center (MTOC) mapping showed that microtubules arise from two MTOCs located near the poles of the iridophore and run parallel to, and in between, individual crystals. This suggests that dynein drives crystal angle change in response to NE by binding to the limiting membrane surrounding individual crystals and walking toward microtubule minus ends. Finally, we found that intracellular cAMP regulates the color change process. Together, our results provide mechanistic insight into the cellular machinery that drives structural color change. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

19. Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

Author

Thompson, Eric M, Hielscher, Thomas, Bouffet, Eric, Remke, Marc, Luu, Betty, Gururangan, Sridharan, McLendon, Roger E, Bigner, Darell D, Lipp, Eric S, Perreault, Sebastien, Cho, Yoon-Jae, Grant, Gerald, Kim, Seung-Ki, Lee, Ji Yeoun, Rao, Amulya A Nageswara, Giannini, Caterina, Li, Kay Ka Wai, Ng, Ho-Keung, Yao, Yu, Kumabe, Toshihiro, Tominaga, Teiji, Grajkowska, Wieslawa A, Perek-Polnik, Marta, Low, David CY, Seow, Wan Tew, Chang, Kenneth TE, Mora, Jaume, Pollack, Ian F, Hamilton, Ronald L, Leary, Sarah, Moore, Andrew S, Ingram, Wendy J, Hallahan, Andrew R, Jouvet, Anne, Fèvre-Montange, Michelle, Vasiljevic, Alexandre, Faure-Conter, Cecile, Shofuda, Tomoko, Kagawa, Naoki, Hashimoto, Naoya, Jabado, Nada, Weil, Alexander G, Gayden, Tenzin, Wataya, Takafumi, Shalaby, Tarek, Grotzer, Michael, Zitterbart, Karel, Sterba, Jaroslav, Kren, Leos, Hortobágyi, Tibor, Klekner, Almos, László, Bognár, Pócza, Tímea, Hauser, Peter, Schüller, Ulrich, Jung, Shin, Jang, Woo-Youl, French, Pim J, Kros, Johan M, van Veelen, Marie-Lise C, Massimi, Luca, Leonard, Jeffrey R, Rubin, Joshua B, Vibhakar, Rajeev, Chambless, Lola B, Cooper, Michael K, Thompson, Reid C, Faria, Claudia C, Carvalho, Alice, Nunes, Sofia, Pimentel, José, Fan, Xing, Muraszko, Karin M, López-Aguilar, Enrique, Lyden, David, Garzia, Livia, Shih, David JH, Kijima, Noriyuki, Schneider, Christian, Adamski, Jennifer, Northcott, Paul A, Kool, Marcel, Jones, David TW, Chan, Jennifer A, Nikolic, Ana, Garre, Maria Luisa, Van Meir, Erwin G, Osuka, Satoru, Olson, Jeffrey J, Jahangiri, Arman, Castro, Brandyn A, Gupta, Nalin, Weiss, William A, Moxon-Emre, Iska, Mabbott, Donald J, Lassaletta, Alvaro, Hawkins, Cynthia E, Tabori, Uri, Drake, James, and Kulkarni, Abhaya

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Oncology and Carcinogenesis, Brain Disorders, Rare Diseases, Brain Cancer, Pediatric Research Initiative, Pediatric, Cancer, Adult, Brain Neoplasms, Canada, Child, Child, Preschool, Combined Modality Therapy, Disease Progression, Disease-Free Survival, Female, Humans, Infant, Magnetic Resonance Imaging, Male, Medulloblastoma, Prognosis, Retrospective Studies, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundPatients with incomplete surgical resection of medulloblastoma are controversially regarded as having a marker of high-risk disease, which leads to patients undergoing aggressive surgical resections, so-called second-look surgeries, and intensified chemoradiotherapy. All previous studies assessing the clinical importance of extent of resection have not accounted for molecular subgroup. We analysed the prognostic value of extent of resection in a subgroup-specific manner.MethodsWe retrospectively identified patients who had a histological diagnosis of medulloblastoma and complete data about extent of resection and survival from centres participating in the Medulloblastoma Advanced Genomics International Consortium. We collected from resections done between April, 1997, and February, 2013, at 35 international institutions. We established medulloblastoma subgroup affiliation by gene expression profiling on frozen or formalin-fixed paraffin-embedded tissues. We classified extent of resection on the basis of postoperative imaging as gross total resection (no residual tumour), near-total resection (30 Gy vs no craniospinal irradiation). The primary analysis outcome was the effect of extent of resection by molecular subgroup and the effects of other clinical variables on overall and progression-free survival.FindingsWe included 787 patients with medulloblastoma (86 with WNT tumours, 242 with SHH tumours, 163 with group 3 tumours, and 296 with group 4 tumours) in our multivariable Cox models of progression-free and overall survival. We found that the prognostic benefit of increased extent of resection for patients with medulloblastoma is attenuated after molecular subgroup affiliation is taken into account. We identified a progression-free survival benefit for gross total resection over sub-total resection (hazard ratio [HR] 1·45, 95% CI 1·07-1·96, p=0·16) but no overall survival benefit (HR 1·23, 0·87-1·72, p=0·24). We saw no progression-free survival or overall survival benefit for gross total resection compared with near-total resection (HR 1·05, 0·71-1·53, p=0·8158 for progression-free survival and HR 1·14, 0·75-1·72, p=0·55 for overall survival). No significant survival benefit existed for greater extent of resection for patients with WNT, SHH, or group 3 tumours (HR 1·03, 0·67-1·58, p=0·89 for sub-total resection vs gross total resection). For patients with group 4 tumours, gross total resection conferred a benefit to progression-free survival compared with sub-total resection (HR 1·97, 1·22-3·17, p=0·0056), especially for those with metastatic disease (HR 2·22, 1·00-4·93, p=0·050). However, gross total resection had no effect on overall survival compared with sub-total resection in patients with group 4 tumours (HR 1·67, 0·93-2·99, p=0·084).InterpretationThe prognostic benefit of increased extent of resection for patients with medulloblastoma is attenuated after molecular subgroup affiliation is taken into account. Although maximum safe surgical resection should remain the standard of care, surgical removal of small residual portions of medulloblastoma is not recommended when the likelihood of neurological morbidity is high because there is no definitive benefit to gross total resection compared with near-total resection.FundingCanadian Cancer Society Research Institute, Terry Fox Research Institute, Canadian Institutes of Health Research, National Institutes of Health, Pediatric Brain Tumor Foundation, and the Garron Family Chair in Childhood Cancer Research.

Published
2016

20. New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.

Author

Sturm, Dominik, Orr, Brent A, Toprak, Umut H, Hovestadt, Volker, Jones, David TW, Capper, David, Sill, Martin, Buchhalter, Ivo, Northcott, Paul A, Leis, Irina, Ryzhova, Marina, Koelsche, Christian, Pfaff, Elke, Allen, Sariah J, Balasubramanian, Gnanaprakash, Worst, Barbara C, Pajtler, Kristian W, Brabetz, Sebastian, Johann, Pascal D, Sahm, Felix, Reimand, Jüri, Mackay, Alan, Carvalho, Diana M, Remke, Marc, Phillips, Joanna J, Perry, Arie, Cowdrey, Cynthia, Drissi, Rachid, Fouladi, Maryam, Giangaspero, Felice, Łastowska, Maria, Grajkowska, Wiesława, Scheurlen, Wolfram, Pietsch, Torsten, Hagel, Christian, Gojo, Johannes, Lötsch, Daniela, Berger, Walter, Slavc, Irene, Haberler, Christine, Jouvet, Anne, Holm, Stefan, Hofer, Silvia, Prinz, Marco, Keohane, Catherine, Fried, Iris, Mawrin, Christian, Scheie, David, Mobley, Bret C, Schniederjan, Matthew J, Santi, Mariarita, Buccoliero, Anna M, Dahiya, Sonika, Kramm, Christof M, von Bueren, André O, von Hoff, Katja, Rutkowski, Stefan, Herold-Mende, Christel, Frühwald, Michael C, Milde, Till, Hasselblatt, Martin, Wesseling, Pieter, Rößler, Jochen, Schüller, Ulrich, Ebinger, Martin, Schittenhelm, Jens, Frank, Stephan, Grobholz, Rainer, Vajtai, Istvan, Hans, Volkmar, Schneppenheim, Reinhard, Zitterbart, Karel, Collins, V Peter, Aronica, Eleonora, Varlet, Pascale, Puget, Stephanie, Dufour, Christelle, Grill, Jacques, Figarella-Branger, Dominique, Wolter, Marietta, Schuhmann, Martin U, Shalaby, Tarek, Grotzer, Michael, van Meter, Timothy, Monoranu, Camelia-Maria, Felsberg, Jörg, Reifenberger, Guido, Snuderl, Matija, Forrester, Lynn Ann, Koster, Jan, Versteeg, Rogier, Volckmann, Richard, van Sluis, Peter, Wolf, Stephan, Mikkelsen, Tom, Gajjar, Amar, Aldape, Kenneth, Moore, Andrew S, Taylor, Michael D, and Jones, Chris

Subjects
Humans, Neuroectodermal Tumors, Central Nervous System Neoplasms, Trans-Activators, Proto-Oncogene Proteins, Tumor Suppressor Proteins, Repressor Proteins, Gene Expression Profiling, Signal Transduction, DNA Methylation, Gene Expression Regulation, Neoplastic, Amino Acid Sequence, Molecular Sequence Data, Child, Forkhead Transcription Factors, Neuroblastoma, Cancer, Pediatric, Neurosciences, Brain Disorders, Rare Diseases, Orphan Drug, Brain Cancer, Pediatric Research Initiative, Pediatric Cancer, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors. From the remaining fraction of CNS-PNETs, we identify four new CNS tumor entities, each associated with a recurrent genetic alteration and distinct histopathological and clinical features. These new molecular entities, designated "CNS neuroblastoma with FOXR2 activation (CNS NB-FOXR2)," "CNS Ewing sarcoma family tumor with CIC alteration (CNS EFT-CIC)," "CNS high-grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1)," and "CNS high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR)," will enable meaningful clinical trials and the development of therapeutic strategies for patients affected by poorly differentiated CNS tumors.

Published
2016

22. Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer

Author

Wong, Marie, Mayoh, Chelsea, Lau, Loretta M. S., Khuong-Quang, Dong-Anh, Pinese, Mark, Kumar, Amit, Barahona, Paulette, Wilkie, Emilie E., Sullivan, Patricia, Bowen-James, Rachel, Syed, Mustafa, Martincorena, Iñigo, Abascal, Federico, Sherstyuk, Alexandra, Bolanos, Noemi A., Baber, Jonathan, Priestley, Peter, Dolman, M. Emmy M., Fleuren, Emmy D. G., Gauthier, Marie-Emilie, Mould, Emily V. A., Gayevskiy, Velimir, Gifford, Andrew J., Grebert-Wade, Dylan, Strong, Patrick A., Manouvrier, Elodie, Warby, Meera, Thomas, David M., Kirk, Judy, Tucker, Katherine, O’Brien, Tracey, Alvaro, Frank, McCowage, Geoffry B., Dalla-Pozza, Luciano, Gottardo, Nicholas G., Tapp, Heather, Wood, Paul, Khaw, Seong-Lin, Hansford, Jordan R., Moore, Andrew S., Norris, Murray D., Trahair, Toby N., Lock, Richard B., Tyrrell, Vanessa, Haber, Michelle, Marshall, Glenn M., Ziegler, David S., Ekert, Paul G., and Cowley, Mark J.

Published
2020
Full Text
View/download PDF

25. Exploring NK cell receptor dynamics in paediatric leukaemias: implications for immunotherapy and prognosis.

Author

Tu, Cui, Buckle, Irina, Leal Rojas, Ingrid, Rossi, Gustavo Rodrigues, Sester, David P, Moore, Andrew S, Radford, Kristen, Guillerey, Camille, and Souza‐Fonseca‐Guimaraes, Fernando

Subjects
KILLER cells, CELL receptors, CORD blood, ACUTE myeloid leukemia, LEUKEMIA
Abstract

Objectives: Immunotherapies targeting natural killer (NK) cell receptors have shown promise against leukaemia. Unfortunately, cancer immunosuppressive mechanisms that alter NK cell phenotype prevent such approaches from being successful. The study utilises advanced cytometry to examine how cancer immunosuppressive pathways affect NK cell phenotypic changes in clinical samples. Methods: In this study, we conducted a high‐dimensional examination of the cell surface expression of 16 NK cell receptors in paediatric patients with acute myeloid leukaemia and acute lymphoblastic leukaemia, as well as in samples of non‐age matched adult peripheral blood (APB) and umbilical cord blood (UCB). An unsupervised analysis was carried out in order to identify NK cell populations present in paediatric leukaemias. Results: We observed that leukaemia NK cells clustered together with UCB NK cells and expressed relatively higher levels of the NKG2A receptor compared to APB NK cells. In addition, CD56dimCD16+CD57− NK cells lacking NKG2A expression were mainly absent in paediatric leukaemia patients. However, CD56br NK cell populations expressing high levels of NKG2A were highly represented in paediatric leukaemia patients. NKG2A expression on leukaemia NK cells was found to be positively correlated with the expression of its ligand, suggesting that the NKG2A‐HLA‐E interaction may play a role in modifying NK cell responses to leukaemia cells. Conclusion: We provide an in‐depth analysis of NK cell populations in paediatric leukaemia patients. These results support the development of immunotherapies targeting immunosuppressive receptors, such as NKG2A, to enhance innate immunity against paediatric leukaemia. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

26. Biologic and clinical features of childhood gamma delta T-ALL: identification of STAG2/LMO2 γδ T-ALL as an extremely high risk leukemia in the very young

Author

Kimura, Shunsuke, primary, Polonen, Petri, additional, Montefiori, Lindsey, additional, Park, Chun Shik, additional, Iacobucci, Ilaria, additional, Yeoh, Allen EJ, additional, Attarbaschi, Andishe, additional, Moore, Andrew S., additional, Brown, Anthony, additional, Manabe, Atsushi, additional, Buldini, Barbara, additional, Freeman, Burgess B., additional, Chen, Chelsey, additional, Cheng, Cheng, additional, Kean Hui, Chiew, additional, Li, Chi-Kong, additional, Pui, Ching-Hon, additional, Qu, Chunxu, additional, Tomizawa, Daisuke, additional, Teachey, David T., additional, Varotto, Elena, additional, M Paietta, Elisabeth, additional, Arnold, Elizabeth D., additional, Locatelli, Franco, additional, Escherich, Gabriele, additional, Elisa Muhle, Hannah, additional, Marquart, Hanne Vibeke, additional, de Groot-Kruseman, Hester A., additional, Rowe, Jacob M, additional, Stary, Jan, additional, Trka, Jan, additional, Choi, John Kim, additional, Meijerink, Jules P.P., additional, Yang, Jun J., additional, Takita, Junko, additional, Pawinska-Wasikowska, Katarzyna, additional, Roberts, Kathryn G., additional, Han, Katie, additional, Caldwell, Kenneth J., additional, Schmiegelow, Kjeld, additional, Crews, Kristine R., additional, Eguchi, Mariko, additional, Schrappe, Martin, additional, Zimmerman, Martin, additional, Takagi, Masatoshi, additional, Maybury, Mellissa, additional, Svaton, Michael, additional, Reiterova, Michaela, additional, Kicinski, Michal, additional, Prater, Mollie S., additional, Kato, Motohiro, additional, Reyes, Noemi, additional, Spinelli, Orietta, additional, Thomas, Paul, additional, Mazilier, Pauline, additional, Gao, Qingsong, additional, Masetti, Riccardo, additional, Kotecha, Rishi S, additional, Pieters, Rob, additional, Elitzur, Sarah, additional, Luger, Selina M., additional, Mitchell, Sharnise, additional, Pruett-Miller, Shondra M., additional, Shen, Shuhong, additional, Jeha, Sima, additional, Kohrer, Stefan, additional, Kornblau, Steven M, additional, Skoczen, Szymon, additional, Miyamura, Takako, additional, Vincent, Tiffaney L, additional, Imamura, Toshihiko, additional, Conter, Valentino, additional, Tang, Yanjing, additional, Liu, Yen-Chun, additional, Chang, Yunchao, additional, Gu, Zhaohui, additional, Cheng, Zhongshan, additional, Yinmei, Zhou, additional, Inaba, Hiroto, additional, and Mullighan, Charles G., additional

Published
2023
Full Text
View/download PDF

28. Reproducible Bioinformatics Analysis Workflows for Detecting IGH Gene Fusions in B-Cell Acute Lymphoblastic Leukaemia Patients

Author

Thomson, Ashlee J., primary, Rehn, Jacqueline A., additional, Heatley, Susan L., additional, Eadie, Laura N., additional, Page, Elyse C., additional, Schutz, Caitlin, additional, McClure, Barbara J., additional, Sutton, Rosemary, additional, Dalla-Pozza, Luciano, additional, Moore, Andrew S., additional, Greenwood, Matthew, additional, Kotecha, Rishi S., additional, Fong, Chun Y., additional, Yong, Agnes S. M., additional, Yeung, David T., additional, Breen, James, additional, and White, Deborah L., additional

Published
2023
Full Text
View/download PDF

32. Providing Australian children and adolescents with equitable access to new and emerging therapies through clinical trials: a call to action.

Author

Lorentzos, Michelle S, Metz, David, Moore, Andrew S, Fawcett, Laura K, Bray, Paula, Attwood, Lani, Munns, Craig F, and Davidson, Andrew

Abstract

This article discusses the importance of increasing access to new therapies for Australian children and adolescents through clinical trials. It emphasizes the need for investment and a coordinated national approach to ensure that Australian children do not fall behind their international peers. The article highlights the benefits of collaborative approaches and strategic investment in pediatric clinical trials, as well as the challenges in delivering high-quality trials in this population. It acknowledges the additional challenges faced in Australia due to distance and regulatory factors, and calls for equitable access to emerging treatments for all Australian children, regardless of their circumstances. The article concludes by emphasizing the need for national investment in pediatric clinical trial delivery in Australia. [Extracted from the article]

Published
2024
Full Text
View/download PDF

34. The genetic basis and cell of origin of mixed phenotype acute leukaemia

Author

Alexander, Thomas B., Gu, Zhaohui, Iacobucci, Ilaria, Dickerson, Kirsten, Choi, John K., Xu, Beisi, Payne-Turner, Debbie, Yoshihara, Hiroki, Loh, Mignon L., Horan, John, Buldini, Barbara, Basso, Giuseppe, Elitzur, Sarah, de Haas, Valerie, Zwaan, C. Michel, Yeoh, Allen, Reinhardt, Dirk, Tomizawa, Daisuke, Kiyokawa, Nobutaka, Lammens, Tim, De Moerloose, Barbara, Catchpoole, Daniel, Hori, Hiroki, Moorman, Anthony, Moore, Andrew S., Hrusak, Ondrej, Meshinchi, Soheil, Orgel, Etan, Devidas, Meenakshi, Borowitz, Michael, Wood, Brent, Heerema, Nyla A., Carrol, Andrew, Yang, Yung-Li, Smith, Malcolm A., Davidsen, Tanja M., Hermida, Leandro C., Gesuwan, Patee, Marra, Marco A., Ma, Yussanne, Mungall, Andrew J., Moore, Richard A., Jones, Steven J. M., Valentine, Marcus, Janke, Laura J., Rubnitz, Jeffrey E., Pui, Ching-Hon, Ding, Liang, Liu, Yu, Zhang, Jinghui, Nichols, Kim E., Downing, James R., Cao, Xueyuan, Shi, Lei, Pounds, Stanley, Newman, Scott, Pei, Deqing, Guidry Auvil, Jaime M., Gerhard, Daniela S., Hunger, Stephen P., Inaba, Hiroto, and Mullighan, Charles G.

Published
2018
Full Text
View/download PDF

35. Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells

Author

Vinci, Mara, Burford, Anna, Molinari, Valeria, Kessler, Ketty, Popov, Sergey, Clarke, Matthew, Taylor, Kathryn R., Pemberton, Helen N., Lord, Christopher J., Gutteridge, Alice, Forshew, Tim, Carvalho, Diana, Marshall, Lynley V., Qin, Elizabeth Y., Ingram, Wendy J., Moore, Andrew S., Ng, Ho-Keung, Trabelsi, Saoussen, H’mida-Ben Brahim, Dorra, Entz-Werle, Natacha, Zacharoulis, Stergios, Vaidya, Sucheta, Mandeville, Henry C., Bridges, Leslie R., Martin, Andrew J., Al-Sarraj, Safa, Chandler, Christopher, Sunol, Mariona, Mora, Jaume, de Torres, Carmen, Cruz, Ofelia, Carcaboso, Angel M., Monje, Michelle, Mackay, Alan, and Jones, Chris

Published
2018
Full Text
View/download PDF

37. Data from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes

Author

Clarke, Matthew, primary, Mackay, Alan, primary, Ismer, Britta, primary, Pickles, Jessica C., primary, Tatevossian, Ruth G., primary, Newman, Scott, primary, Bale, Tejus A., primary, Stoler, Iris, primary, Izquierdo, Elisa, primary, Temelso, Sara, primary, Carvalho, Diana M., primary, Molinari, Valeria, primary, Burford, Anna, primary, Howell, Louise, primary, Virasami, Alex, primary, Fairchild, Amy R., primary, Avery, Aimee, primary, Chalker, Jane, primary, Kristiansen, Mark, primary, Haupfear, Kelly, primary, Dalton, James D., primary, Orisme, Wilda, primary, Wen, Ji, primary, Hubank, Michael, primary, Kurian, Kathreena M., primary, Rowe, Catherine, primary, Maybury, Mellissa, primary, Crosier, Stephen, primary, Knipstein, Jeffrey, primary, Schüller, Ulrich, primary, Kordes, Uwe, primary, Kram, David E., primary, Snuderl, Matija, primary, Bridges, Leslie, primary, Martin, Andrew J., primary, Doey, Lawrence J., primary, Al-Sarraj, Safa, primary, Chandler, Christopher, primary, Zebian, Bassel, primary, Cairns, Claire, primary, Natrajan, Rachael, primary, Boult, Jessica K.R., primary, Robinson, Simon P., primary, Sill, Martin, primary, Dunkel, Ira J., primary, Gilheeney, Stephen W., primary, Rosenblum, Marc K., primary, Hughes, Debbie, primary, Proszek, Paula Z., primary, Macdonald, Tobey J., primary, Preusser, Matthias, primary, Haberler, Christine, primary, Slavc, Irene, primary, Packer, Roger, primary, Ng, Ho-Keung, primary, Caspi, Shani, primary, Popović, Mara, primary, Faganel Kotnik, Barbara, primary, Wood, Matthew D., primary, Baird, Lissa, primary, Davare, Monika Ashok, primary, Solomon, David A., primary, Olsen, Thale Kristin, primary, Brandal, Petter, primary, Farrell, Michael, primary, Cryan, Jane B., primary, Capra, Michael, primary, Karremann, Michael, primary, Schittenhelm, Jens, primary, Schuhmann, Martin U., primary, Ebinger, Martin, primary, Dinjens, Winand N.M., primary, Kerl, Kornelius, primary, Hettmer, Simone, primary, Pietsch, Torsten, primary, Andreiuolo, Felipe, primary, Driever, Pablo Hernáiz, primary, Korshunov, Andrey, primary, Hiddingh, Lotte, primary, Worst, Barbara C., primary, Sturm, Dominik, primary, Zuckermann, Marc, primary, Witt, Olaf, primary, Bloom, Tabitha, primary, Mitchell, Clare, primary, Miele, Evelina, primary, Colafati, Giovanna Stefania, primary, Diomedi-Camassei, Francesca, primary, Bailey, Simon, primary, Moore, Andrew S., primary, Hassall, Timothy E.G., primary, Lowis, Stephen P., primary, Tsoli, Maria, primary, Cowley, Mark J., primary, Ziegler, David S., primary, Karajannis, Matthias A., primary, Aquilina, Kristian, primary, Hargrave, Darren R., primary, Carceller, Fernando, primary, Marshall, Lynley V., primary, von Deimling, Andreas, primary, Kramm, Christof M., primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Baker, Suzanne J., primary, Mastronuzzi, Angela, primary, Carai, Andrea, primary, Vinci, Maria, primary, Capper, David, primary, Popov, Sergey, primary, Ellison, David W., primary, Jacques, Thomas S., primary, Jones, David T.W., primary, and Jones, Chris, primary

Published
2023
Full Text
View/download PDF

38. Supplementary Data from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes

Author

Clarke, Matthew, primary, Mackay, Alan, primary, Ismer, Britta, primary, Pickles, Jessica C., primary, Tatevossian, Ruth G., primary, Newman, Scott, primary, Bale, Tejus A., primary, Stoler, Iris, primary, Izquierdo, Elisa, primary, Temelso, Sara, primary, Carvalho, Diana M., primary, Molinari, Valeria, primary, Burford, Anna, primary, Howell, Louise, primary, Virasami, Alex, primary, Fairchild, Amy R., primary, Avery, Aimee, primary, Chalker, Jane, primary, Kristiansen, Mark, primary, Haupfear, Kelly, primary, Dalton, James D., primary, Orisme, Wilda, primary, Wen, Ji, primary, Hubank, Michael, primary, Kurian, Kathreena M., primary, Rowe, Catherine, primary, Maybury, Mellissa, primary, Crosier, Stephen, primary, Knipstein, Jeffrey, primary, Schüller, Ulrich, primary, Kordes, Uwe, primary, Kram, David E., primary, Snuderl, Matija, primary, Bridges, Leslie, primary, Martin, Andrew J., primary, Doey, Lawrence J., primary, Al-Sarraj, Safa, primary, Chandler, Christopher, primary, Zebian, Bassel, primary, Cairns, Claire, primary, Natrajan, Rachael, primary, Boult, Jessica K.R., primary, Robinson, Simon P., primary, Sill, Martin, primary, Dunkel, Ira J., primary, Gilheeney, Stephen W., primary, Rosenblum, Marc K., primary, Hughes, Debbie, primary, Proszek, Paula Z., primary, Macdonald, Tobey J., primary, Preusser, Matthias, primary, Haberler, Christine, primary, Slavc, Irene, primary, Packer, Roger, primary, Ng, Ho-Keung, primary, Caspi, Shani, primary, Popović, Mara, primary, Faganel Kotnik, Barbara, primary, Wood, Matthew D., primary, Baird, Lissa, primary, Davare, Monika Ashok, primary, Solomon, David A., primary, Olsen, Thale Kristin, primary, Brandal, Petter, primary, Farrell, Michael, primary, Cryan, Jane B., primary, Capra, Michael, primary, Karremann, Michael, primary, Schittenhelm, Jens, primary, Schuhmann, Martin U., primary, Ebinger, Martin, primary, Dinjens, Winand N.M., primary, Kerl, Kornelius, primary, Hettmer, Simone, primary, Pietsch, Torsten, primary, Andreiuolo, Felipe, primary, Driever, Pablo Hernáiz, primary, Korshunov, Andrey, primary, Hiddingh, Lotte, primary, Worst, Barbara C., primary, Sturm, Dominik, primary, Zuckermann, Marc, primary, Witt, Olaf, primary, Bloom, Tabitha, primary, Mitchell, Clare, primary, Miele, Evelina, primary, Colafati, Giovanna Stefania, primary, Diomedi-Camassei, Francesca, primary, Bailey, Simon, primary, Moore, Andrew S., primary, Hassall, Timothy E.G., primary, Lowis, Stephen P., primary, Tsoli, Maria, primary, Cowley, Mark J., primary, Ziegler, David S., primary, Karajannis, Matthias A., primary, Aquilina, Kristian, primary, Hargrave, Darren R., primary, Carceller, Fernando, primary, Marshall, Lynley V., primary, von Deimling, Andreas, primary, Kramm, Christof M., primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Baker, Suzanne J., primary, Mastronuzzi, Angela, primary, Carai, Andrea, primary, Vinci, Maria, primary, Capper, David, primary, Popov, Sergey, primary, Ellison, David W., primary, Jacques, Thomas S., primary, Jones, David T.W., primary, and Jones, Chris, primary

Published
2023
Full Text
View/download PDF

39. Supplementary Table S3 from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes

Author

Clarke, Matthew, primary, Mackay, Alan, primary, Ismer, Britta, primary, Pickles, Jessica C., primary, Tatevossian, Ruth G., primary, Newman, Scott, primary, Bale, Tejus A., primary, Stoler, Iris, primary, Izquierdo, Elisa, primary, Temelso, Sara, primary, Carvalho, Diana M., primary, Molinari, Valeria, primary, Burford, Anna, primary, Howell, Louise, primary, Virasami, Alex, primary, Fairchild, Amy R., primary, Avery, Aimee, primary, Chalker, Jane, primary, Kristiansen, Mark, primary, Haupfear, Kelly, primary, Dalton, James D., primary, Orisme, Wilda, primary, Wen, Ji, primary, Hubank, Michael, primary, Kurian, Kathreena M., primary, Rowe, Catherine, primary, Maybury, Mellissa, primary, Crosier, Stephen, primary, Knipstein, Jeffrey, primary, Schüller, Ulrich, primary, Kordes, Uwe, primary, Kram, David E., primary, Snuderl, Matija, primary, Bridges, Leslie, primary, Martin, Andrew J., primary, Doey, Lawrence J., primary, Al-Sarraj, Safa, primary, Chandler, Christopher, primary, Zebian, Bassel, primary, Cairns, Claire, primary, Natrajan, Rachael, primary, Boult, Jessica K.R., primary, Robinson, Simon P., primary, Sill, Martin, primary, Dunkel, Ira J., primary, Gilheeney, Stephen W., primary, Rosenblum, Marc K., primary, Hughes, Debbie, primary, Proszek, Paula Z., primary, Macdonald, Tobey J., primary, Preusser, Matthias, primary, Haberler, Christine, primary, Slavc, Irene, primary, Packer, Roger, primary, Ng, Ho-Keung, primary, Caspi, Shani, primary, Popović, Mara, primary, Faganel Kotnik, Barbara, primary, Wood, Matthew D., primary, Baird, Lissa, primary, Davare, Monika Ashok, primary, Solomon, David A., primary, Olsen, Thale Kristin, primary, Brandal, Petter, primary, Farrell, Michael, primary, Cryan, Jane B., primary, Capra, Michael, primary, Karremann, Michael, primary, Schittenhelm, Jens, primary, Schuhmann, Martin U., primary, Ebinger, Martin, primary, Dinjens, Winand N.M., primary, Kerl, Kornelius, primary, Hettmer, Simone, primary, Pietsch, Torsten, primary, Andreiuolo, Felipe, primary, Driever, Pablo Hernáiz, primary, Korshunov, Andrey, primary, Hiddingh, Lotte, primary, Worst, Barbara C., primary, Sturm, Dominik, primary, Zuckermann, Marc, primary, Witt, Olaf, primary, Bloom, Tabitha, primary, Mitchell, Clare, primary, Miele, Evelina, primary, Colafati, Giovanna Stefania, primary, Diomedi-Camassei, Francesca, primary, Bailey, Simon, primary, Moore, Andrew S., primary, Hassall, Timothy E.G., primary, Lowis, Stephen P., primary, Tsoli, Maria, primary, Cowley, Mark J., primary, Ziegler, David S., primary, Karajannis, Matthias A., primary, Aquilina, Kristian, primary, Hargrave, Darren R., primary, Carceller, Fernando, primary, Marshall, Lynley V., primary, von Deimling, Andreas, primary, Kramm, Christof M., primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Baker, Suzanne J., primary, Mastronuzzi, Angela, primary, Carai, Andrea, primary, Vinci, Maria, primary, Capper, David, primary, Popov, Sergey, primary, Ellison, David W., primary, Jacques, Thomas S., primary, Jones, David T.W., primary, and Jones, Chris, primary

Published
2023
Full Text
View/download PDF

43. ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma

Author

Carvalho, Diana, Taylor, Kathryn R., Olaciregui, Nagore Gene, Molinari, Valeria, Clarke, Matthew, Mackay, Alan, Ruddle, Ruth, Henley, Alan, Valenti, Melanie, Hayes, Angela, Brandon, Alexis De Haven, Eccles, Suzanne A., Raynaud, Florence, Boudhar, Aicha, Monje, Michelle, Popov, Sergey, Moore, Andrew S., Mora, Jaume, Cruz, Ofelia, Vinci, Mara, Brennan, Paul E., Bullock, Alex N., Carcaboso, Angel Montero, and Jones, Chris

Published
2019
Full Text
View/download PDF

45. Additional file 1 of A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer

Author

Mayoh, Chelsea, Gifford, Andrew J., Terry, Rachael, Lau, Loretta M. S., Wong, Marie, Rao, Padmashree, Shai-Hee, Tyler, Saletta, Federica, Khuong-Quang, Dong-Anh, Qin, Vicky, Mateos, Marion K., Meyran, Deborah, Miller, Katherine E., Yuksel, Aysen, Mould, Emily V. A., Bowen-James, Rachel, Govender, Dinisha, Senapati, Akanksha, Zhukova, Nataliya, Omer, Natacha, Dholaria, Hetal, Alvaro, Frank, Tapp, Heather, Diamond, Yonatan, Pozza, Luciano Dalla, Moore, Andrew S., Nicholls, Wayne, Gottardo, Nicholas G., McCowage, Geoffrey, Hansford, Jordan R., Khaw, Seong-Lin, Wood, Paul J., Catchpoole, Daniel, Cottrell, Catherine E., Mardis, Elaine R., Marshall, Glenn M., Tyrrell, Vanessa, Haber, Michelle, Ziegler, David S., Vittorio, Orazio, Trapani, Joseph A., Cowley, Mark J., Neeson, Paul J., and Ekert, Paul G.

Abstract

Additional file 1: Table S1. Immune checkpoint and regulatory genes. Fig. S1. PRISM clinical trial study schema. Fig. S2. Cohort overview. Fig. S3. Deconvolution algorithms exhibit high concordance and an abundance of M2 macrophages in paediatric cancer. Fig. S4. Immunohistochemistry identifies paediatric patients with T-cell infiltrated tumours. Fig. S5. Prior treatment and steroid administration do not significantly affect T-cell infiltration. Fig. S6. Distribution of IPASS and T-cell clones are heterogenous across histologies. Fig. S7. IPASS correlations with additional markers of immune infiltration.

Published
2023
Full Text
View/download PDF

47. A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer

Author

Mayoh, Chelsea, primary, Gifford, Andrew J, additional, Terry, Rachael, additional, Lau, Loretta MS, additional, Wong, Marie, additional, Rao, Padmashree, additional, Shai-Hee, Tyler, additional, Saletta, Federica, additional, Khuong-Quang, Dong-Anh, additional, Qin, Vicky, additional, Mateos, Marion, additional, Meyran, Deborah, additional, Miller, Katherine E, additional, Yuksel, Aysen, additional, Mould, Emily VA, additional, Bowen-James, Rachael, additional, Govender, Dinisha, additional, Senapati, Akanksha, additional, Zhukova, Nataliya, additional, Omer, Natacha, additional, Dholaria, Hetal, additional, Alvaro, Frank, additional, Tapp, Heather, additional, Diamond, Yonatan, additional, Pozza, Luciano Dalla, additional, Moore, Andrew S, additional, Nicholls, Wayne, additional, Gottardo, Nicholas G, additional, McCowage, Geoffrey, additional, Hansford, Jordan R, additional, Khaw, Seong-Lin, additional, Wood, Paul J, additional, Catchpoole, Daniel, additional, Cottrell, Catherine E, additional, Mardis, Elaine R, additional, Marshall, Glenn M, additional, Tyrrell, Vanessa, additional, Haber, Michelle, additional, Ziegler, David S, additional, Vittorio, Orazio, additional, Trapani, Joseph A, additional, Cowley, Mark J, additional, Neeson, Paul J, additional, and Ekert, Paul G, additional

Published
2022
Full Text
View/download PDF

49. Motion of single molecular tethers reveals dynamic subdomains at ER-mitochondria contact sites

Author

Obara, Christopher J., primary, Nixon-Abell, Jonathon, additional, Moore, Andrew S., additional, Riccio, Federica, additional, Hoffman, David P., additional, Shtengel, Gleb, additional, Xu, C. Shan, additional, Schaefer, Kathy, additional, Pasolli, H. Amalia, additional, Masson, Jean-Baptiste, additional, Hess, Harald F., additional, Calderon, Christopher P., additional, Blackstone, Craig, additional, and Lippincott-Schwartz, Jennifer, additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results