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172 results on '"Moon, Jung-Il"'

21. Target-dependent inhibition of sympathetic neuron growth via modulation of a BMP signaling pathway

Author

Moon, Jung-Il and Birren, Susan J.

Subjects
Bone morphogenetic proteins -- Growth, Bone morphogenetic proteins -- Analysis, Genetic research -- Growth, Genetic research -- Analysis, Neurons -- Growth, Neurons -- Analysis, Gene expression -- Growth, Gene expression -- Analysis, Company growth, Biological sciences
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ydbio.2007.12.041 Byline: Jung-Il Moon, Susan J. Birren Keywords: Sympathetic neuron; Bone morphogenetic protein; Basic helix-loop-helix transcription factor; Matrix Gla protein; Cardiac myocyte; Target contact; Microarray Abstract: Target-derived factors modulate many aspects of peripheral neuron development including neuronal growth, survival, and maturation. Less is known about how initial target contact regulates changes in gene expression associated with these developmental processes. One early consequence of contact between growing sympathetic neurons and their cardiac myocyte targets is the inhibition of neuronal outgrowth. Analysis of neuronal gene expression following this contact revealed coordinate regulation of a bone morphogenetic protein (BMP)-dependent growth pathway in which basic helix-loop-helix transcription factors and downstream neurofilament expression contribute to the growth dynamics of developing sympathetic neurons. BMP2 had dose-dependent growth-promoting effects on sympathetic neurons cultured in the absence, but not the presence, of myocyte targets, suggesting that target contact alters neuronal responses to BMP signaling. Target contact also induced the expression of matrix Gla protein (MGP), a regulator of BMP function in the vascular system. Increased MGP expression inhibited BMP-dependent neuronal growth and MGP expression increased in sympathetic neurons during the period of target contact in vivo. These experiments establish MGP as a novel regulator of BMP function in the nervous system, and define developmental transitions in BMP responses during sympathetic development. Author Affiliation: Department of Biology, National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02254-9110, USA Article History: Received 10 July 2007; Revised 19 December 2007; Accepted 29 December 2007

Published
2008

25. Generation of Natural Killer Cells with Enhanced Function from a CRISPR/Cas12a-Edited Induced Pluripotent Stem Cell Line

Author

Moon, Jung-Il, primary, Chin, Melissa S, additional, Burden, Andrew T, additional, Sexton, Steven, additional, Wasko, Kevin, additional, Nasser, Jared M, additional, Antony, Lincy P, additional, Wong, Karrie K, additional, Borges, Christopher M, additional, Morgan, Richard A., additional, and Welstead, G. Grant, additional

Published
2020
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28. Impact of vision and hearing impairments on risk of cardiovascular outcomes and mortality in patients with type 2 diabetes: A nationwide cohort study.

Author

Jung, Younhea, Han, Kyungdo, Lee, Ji Min, Park, Hye Yeon, and Moon, Jung Il

Subjects
TYPE 2 diabetes, HEARING disorders, CARDIOVASCULAR diseases risk factors, MEDICAL screening, COHORT analysis, DRUG-eluting stents, AUDIOMETRY
Abstract

Aims/Introduction: The purpose of this study was to investigate the impact of vision and hearing impairments on the risk of adverse cardiovascular outcomes and mortality in patients with type 2 diabetes using a nationwide longitudinal cohort. Materials and Methods: We enrolled 771,128 patients with type 2 diabetes who underwent the National Health Screening Program in 2009. We carried out Cox proportional hazards regression analyses to calculate the hazard ratios (HR) of myocardial infarction (MI), stroke, and mortality in those with or without vision and hearing impairments. Subgroup analyses of patients stratified by age, sex and diabetic retinopathy were carried out. Results: Diabetes patients with either vision or hearing impairment showed higher risk of MI, stroke or death compared with those without. Among the combinations of impairments, patients with both vision and hearing impairments had the highest risk for MI (adjusted HR [aHR] 1.362, 95% confidence interval [CI] 1.252–1.481) and mortality (aHR 1.591, 95% CI 1.532–1.651). Those with only vision impairment showed higher risk of MI (aHR 1.324, 95% CI 1.275–1.375 and aHR 1.117, 95% CI 1.066–1.170, respectively), stroke (aHR 1.318, 95% CI 1.276–1.362 and aHR 1.134 95% CI 1.089–1.180, respectively) and mortality (aHR 1.417, 95% CI 1.390–1.446 and aHR 1.163, 95% CI 1.135–1.191, respectively) compared with those with only hearing impairment. Conclusions: Vision and hearing impairments are independently important risk factors for adverse cardiovascular events and mortality in patients with type 2 diabetes. Vision and hearing impairments synergistically increased the risk of MI and all‐cause deaths, but not stroke. In addition, in patients aged <65 years, the HR of vision impairment was higher than those with vision and hearing impairments. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Spectral domain optical coherence tomography cross-sectional image of optic nerve head during intraocular pressure elevation

Author

Lee, Ji Young, Lee, You Kyung, Moon, Jung Il, and Park, Myoung Hee

Subjects
spectral domain optical coherence tomography, genetic structures, retinal nerve fiver layer, lcsh:Ophthalmology, Clinical Research, lcsh:RE1-994, elevated intraocular pressure, open angle glaucoma, optic nerve head, sense organs, eye diseases
Abstract

AIM: To analyze changes of the optic nerve head (ONH) and peripapillary region during intraocular pressure (IOP) elevation in patients using spectral domain optical coherence tomography (SD-OCT).METHODS: Both an optic disc 200×200 cube scan and a high-definition 5-line raster scan were obtained from open angle glaucoma patients presented with monocular elevation of IOP (≥30 mm Hg) using SD-OCT. Additional baseline characteristics included age, gender, diagnosis, best-corrected visual acuity, refractive error, findings of slit lamp biomicroscopy, findings of dilated stereoscopic examination of the ONH and fundus, IOP, pachymetry findings, and the results of visual field.RESULTS: The 24 patients were selected and divided into two groups:group 1 patients had no history of IOP elevation or glaucoma (n=14), and group 2 patients did have history of IOP elevation or glaucoma (n=10). In each patient, the study eye with elevated IOP was classified into group H (high), and the fellow eye was classified into group L (low). The mean deviation (MD) differed significantly between groups H and L when all eyes were considered (P=0.047) and in group 2 (P=0.042), not in group 1 (P=0.893). Retinal nerve fiber layer (RNFL) average thickness (P=0.050), rim area (P=0.015), vertical cup/disc ratio (P=0.011), cup volume (P=0.028), inferior quadrant RNFL thickness (P=0.017), and clock-hour (1, 5, and 6) RNFL thicknesses (P=0.050, 0.012, and 0.018, respectively), cup depth (P=0.008), central prelaminar layer thickness (P=0.023), mid-inferior prelaminar layer thickness (P=0.023), and nasal retinal slope (P=0.034) were significantly different between the eyes with groups H and L.CONCLUSION:RNFL average thickness, rim area, vertical cup/disc ratio, cup volume, inferior quadrant RNFL thickness, and clock-hour (1, 5, and 6) RNFL thicknesses significantly changed during acute IOP elevation.

Published
2014

41. Efficient Reprogramming of Human Fibroblasts and Blood-Derived Endothelial Progenitor Cells Using Nonmodified RNA for Reprogramming and Immune Evasion

Author

Poleganov, Marco Alexander, primary, Eminli, Sarah, additional, Beissert, Tim, additional, Herz, Stephanie, additional, Moon, Jung-Il, additional, Goldmann, Johanna, additional, Beyer, Arianne, additional, Heck, Rosario, additional, Burkhart, Isabell, additional, Barea Roldan, Diana, additional, Türeci, Özlem, additional, Yi, Kevin, additional, Hamilton, Brad, additional, and Sahin, Ugur, additional

Published
2015
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43. Increased Genomic Integrity of an Improved Protein-Based Mouse Induced Pluripotent Stem Cell Method Compared With Current Viral-Induced Strategies

Author

Park, Hansoo, primary, Kim, Dohoon, additional, Kim, Chun-Hyung, additional, Mills, Ryan E., additional, Chang, Mi-Yoon, additional, Iskow, Rebecca Cheryl, additional, Ko, Sanghyeok, additional, Moon, Jung-Il, additional, Choi, Hyun Woo, additional, Man Yoo, Paulo Sng, additional, Do, Jeong Tae, additional, Han, Min-Joon, additional, Lee, Eun Gyo, additional, Jung, Joon Ki, additional, Zhang, Chengsheng, additional, Lanza, Robert, additional, and Kim, Kwang-Soo, additional

Published
2014
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