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3. Terminology

Author

Moon, Chang Mo, Chun, Hoon Jai, editor, Seol, Sang-Yong, editor, Choi, Myung-Gyu, editor, and Cho, Joo Young, editor

Published
2022
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11. A survey of current practices in post-polypectomy surveillance in Korea.

Author

Kim, Jeongseok, Gweon, Tae-Geun, Kwak, Min Seob, Kim, Su Young, Kim, Seong Jung, Kim, Hyun Gun, Kim, Eun Ran, Hong, Sung Noh, Kim, Eun Sun, Moon, Chang Mo, Myung, Dae Seong, Baek, Dong Hoon, Oh, Shin Ju, Lee, Hyun Jung, Lee, Ji Young, Jung, Yunho, Chun, Jaeyoung, and Yang, Dong-Hoon

Subjects
POLYPECTOMY, COLORECTAL cancer, POLYPS
Abstract

Background/Aims: We investigated the clinical practice patterns of post-polypectomy colonoscopic surveillance among Korean endoscopists. Methods: In a web-based survey conducted between September and November 2021, participants were asked about their preferred surveillance intervals and the patient age at which surveillance was discontinued. Adherence to the recent guidelines of the U.S. Multi-Society Task Force on Colorectal Cancer (USMSTF) was also analyzed. Results: In total, 196 endoscopists completed the survey. The most preferred first surveillance intervals were: a 5-year interval after the removal of 1-2 tubular adenomas < 10 mm; a 3-year interval after the removal of 3-10 tubular adenomas < 10 mm, adenomas = 10 mm, tubulovillous or villous adenomas, = 20 hyperplastic polyps < 10 mm, 1-4 sessile serrated lesions (SSLs) < 10 mm, hyperplastic polyps or SSLs = 10 mm, and traditional serrated adenomas; and a 1-year interval after the removal of adenomas with highgrade dysplasia, >10 adenomas, 5-10 SSLs, and SSLs with dysplasia. In piecemeal resections of large polyps (> 20 mm), surveillance colonoscopy was mostly preferred after 1 year for adenomas and 6 months for SSLs. The mean USMSTF guideline adherence rate was 30.7%. The largest proportion of respondents (40.8%-55.1%) discontinued the surveillance at the patient age of 80-84 years. Conclusions: A significant discrepancy was observed between the preferred post-polypectomy surveillance intervals and recent international guidelines. Individualized measures are required to increase adherence to the guidelines. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Supplementary Data from The Effect of Metformin in Treatment of Adenomas in Patients with Familial Adenomatous Polyposis

Author

Park, Jae Jun, primary, Kim, Byung Chang, primary, Hong, Sung Pil, primary, Seo, Yoojeong, primary, Lee, Hye Sun, primary, Park, Young Sook, primary, Na, Soo-Young, primary, Park, Sung Chul, primary, Park, Jongha, primary, Kim, Jae Hak, primary, Moon, Chang Mo, primary, Huh, Kyu Chan, primary, Park, Soo Jung, primary, Cheon, Jae Hee, primary, Kim, Won Ho, primary, and Kim, Tae Il, primary

Published
2023
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21. Data from The Effect of Metformin in Treatment of Adenomas in Patients with Familial Adenomatous Polyposis

Author

Park, Jae Jun, primary, Kim, Byung Chang, primary, Hong, Sung Pil, primary, Seo, Yoojeong, primary, Lee, Hye Sun, primary, Park, Young Sook, primary, Na, Soo-Young, primary, Park, Sung Chul, primary, Park, Jongha, primary, Kim, Jae Hak, primary, Moon, Chang Mo, primary, Huh, Kyu Chan, primary, Park, Soo Jung, primary, Cheon, Jae Hee, primary, Kim, Won Ho, primary, and Kim, Tae Il, primary

Published
2023
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23. Mutual association between family history of gastric and colorectal cancer and risk of gastric and colorectal cancer.

Author

Jung, Yoon Suk, Tran, Mai Thi Xuan, Park, Boyoung, and Moon, Chang Mo

Subjects
STOMACH cancer, COLORECTAL cancer, DISEASE risk factors, FAMILY history (Medicine), EARLY detection of cancer
Abstract

Background and Aim: We evaluated the associations between gastric cancer (GC) family history (FH) and colorectal cancer (CRC) risk and between CRC FH and GC/gastric adenoma risk. Methods: We used data of participants who underwent national cancer screening between 2013 and 2014. Participants with GC or CRC FH in first‐degree relatives (n = 1 172 750) and those without cancer FH (n = 3 518 250) were matched 1:3 by age and gender. Results: Of the 1 172 750 participants with a FH, 871 104, 264 040, and 37 606 had FHs of only GC, only CRC, and both GC and CRC, respectively. The median follow‐up time was 4.8 years. GC and CRC FHs were associated with increased GC and CRC risks, respectively. GC FH was associated with CRC risk (adjusted hazard ratio 1.05; 95% confidence interval [CI] 1.01–1.10), whereas CRC FH was not associated with the risk of GC or gastric adenoma. However, gastric adenoma risk increased 1.62‐fold (95% CI 1.40–1.87) in participants with FHs of both GC and CRC, demonstrating a significant difference with the 1.39‐fold (95% CI 1.34–1.44) increase in participants with only GC FH. Furthermore, GC risk increased by 5.32 times (95% CI 1.74–16.24) in participants with FHs of both GC and CRC in both parents and siblings. Conclusions: GC FH was significantly associated with a 5% increase in CRC risk. Although CRC FH did not increase GC risk, FH of both GC and CRC further increased the risk of gastric adenoma. FHs of GC and CRC may affect each other's neoplastic lesion risk. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Additional file 1 of Effect of aging on the formation and growth of colonic epithelial organoids by changes in cell cycle arrest through TGF-β-Smad3 signaling

Author

Jo, Min Kyoung, Moon, Chang Mo, Jeon, Hyeon-Jeong, Han, Yerim, Lee, Eun Sook, Kwon, Ji-Hee, Yang, Kyung-Min, Ahn, Young-Ho, Kim, Seong-Eun, Jung, Sung-Ae, and Kim, Tae Il

Abstract

Additional file 1: Supplementary Fig. 1. Protein–protein interaction network of differentially expressed genes. Supplementary Fig. 2. Quantitative RT-PCR analysis of BMP pathway and stem cell signature gene levels in young- and old-mouse organoids. Supplementary Fig. 3. The effect of aging on the formation of colonic epithelial organoids is not dependent on the culture condition. Supplementary Fig. 4. Original blots of Western blot. Supplementary Fig. 5. Original blots of Western blot. Supplementary Fig. 6. Original blots of Western blot. Supplementary Fig. 7. Original blots of Western blot.

Published
2023
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31. Clinical outcomes of acute upper gastrointestinal bleeding according to the risk indicated by Glasgow-Blatchford risk score-computed tomography score in the emergency room

Author

Lee, Hyun Ae, primary, Jung, Hye-Kyung, additional, Kim, Tae Oh, additional, Byeon, Ju-Ran, additional, Jeong, Eui-Sun, additional, Cho, Hyun-Ji, additional, Tae, Chung Hyun, additional, Moon, Chang Mo, additional, Kim, Seong-Eun, additional, Shim, Ki-Nam, additional, and Jung, Sung-Ae, additional

Published
2022
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38. Lethal effects of mitochondria via microfluidics.

Author

Kim, Hyueyun, Ahn, Young‐Ho, Moon, Chang Mo, Kang, Jihee Lee, Woo, Minna, and Kim, Minsuk

Subjects
MITOCHONDRIA, MICROFLUIDICS, BREAST, MICROFLUIDIC devices, CELL anatomy, CELL death
Abstract

Tumor cells can respond to therapeutic agents by morphologic alternations including formation of tunneling nanotubes. Using tomographic microscope, which can detect the internal structure of cells, we found that mitochondria within breast tumor cells migrate to an adjacent tumor cell through a tunneling nanotube. To investigate the relationship between mitochondria and tunneling nanotubes, mitochondria were passed through a microfluidic device that mimick tunneling nanotubes. Mitochondria, through the microfluidic device, released endonuclease G (Endo G) into adjacent tumor cells, which we referred to herein as unsealed mitochondria. Although unsealed mitochondria did not induce cell death by themselves, they induced apoptosis of tumor cells in response to caspase‐3. Importantly, Endo G‐depleted mitochondria were ineffective as lethal agents. Moreover, unsealed mitochondria had synergistic apoptotic effects with doxorubicin in further increasing tumor cell death. Thus, we show that the mitochondria of microfluidics can provide novel strategies toward tumor cell death. [ABSTRACT FROM AUTHOR]

Published
2023
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42. EP1027: DISCORDANCE BETWEEN PATIENT-REPORTED SYMPTOMS AND ENDOSCOPIC MUCOSAL INFLAMMATION IN PATIENTS WITH MODERATE TO SEVERE ULCERATIVE COLITIS

Author

Hong, Ji Taek, primary, Moon, Chang Mo, additional, Shin, Jeong Eun, additional, Ye, Byong Duk, additional, Eun, Chang Soo, additional, Yoon, Soon Man, additional, Cha, Jae Myung, additional, Kim, You Sun, additional, Park, Young Soo, additional, Huh, Kyu Chan, additional, Park, Young-Sook, additional, Cheon, Jae Hee, additional, Jung, Eun Suk, additional, Kim, Youngdoe, additional, and Jung, Su Young, additional

Published
2022
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43. EP1353: CLINICAL FEATURES, OUTCOMES AND RISK FACTORS FOR BLEEDING AFTER ENDOSCOPIC RESECTION OF SUBMUCOSAL INVASIVE COLORECTAL NEOPLASMS

Author

Hong, Ji taek, primary, Choi, Hyuk Soon, additional, Moon, Chang Mo, additional, Lee, Yoojin, additional, Lee, Hyun Jung, additional, Hwang, Sung Wook, additional, Kim, Dae Bum, additional, Kim, Eun Ran, additional, Kim, Kyeong Ok, additional, Lee, Jun, additional, Jung, Yunho, additional, Kim, Hyun Gun, additional, and Byeon, Jeong-Sik, additional

Published
2022
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