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284 results on '"Moody, William E"'

4. Abstract 14291: Novel 4D Procrustes Motion Analysis Applied to CMR Links LMNA Mutation Severity With Myocardial Dynamics

Author

Topriceanu, Constantin-Cristian, Al-Farih, Mashael, Joy, George, Chan, Fiona, Webber, Matthew, Ilie-Ablachim, Denis C., Shiwani, Hunain, Pettit, Stephen, OʼBrien, Ben, Choapde, Sandesh, Hingorani, Aaron, Hughes, Alun, Mohiddin, Saidi, Savvatis, Konstantinos, Moody, William E, Steeds, Richard P, Moon, James C, Puddu, Paolo Emilio, Barison, Andrea, Piras, Paolo, and Captur, Gabriella

Published
2023
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12. Utility of exercise-stress echocardiography for pre-pregnancy risk stratification in women with left heart obstruction

Author

Liu, Boyang, primary, Malone, Sean, additional, Knight BMedSci, Tamlyn, additional, Turvey-Haigh, Lauren, additional, Castleman, James, additional, Morris, R. Katie, additional, Al-Sakini, Nada, additional, Bradlow, William, additional, Thorne, Sara, additional, Steeds, Richard P., additional, Hudsmith, Lucy E., additional, and Moody, William E., additional

Published
2023
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25. Progression of echocardiographic parameters and prognosis in transthyretin cardiac amyloidosis

Author

Chacko, Liza, primary, Karia, Nina, additional, Venneri, Lucia, additional, Bandera, Francesco, additional, Passo, Beatrice Dal, additional, Buonamici, Lodovico, additional, Lazari, Jonathan, additional, Ioannou, Adam, additional, Porcari, Aldostefano, additional, Patel, Rishi, additional, Razvi, Yousuf, additional, Brown, James, additional, Knight, Daniel, additional, Martinez‐Naharro, Ana, additional, Whelan, Carol, additional, Quarta, Candida C., additional, Manisty, Charlotte, additional, Moon, James, additional, Rowczenio, Dorota, additional, Gilbertson, Janet A., additional, Lachmann, Helen, additional, Wechelakar, Ashutosh, additional, Petrie, Aviva, additional, Moody, William E., additional, Steeds, Richard P., additional, Potena, Luciano, additional, Riefolo, Mattia, additional, Leone, Ornella, additional, Rapezzi, Claudio, additional, Hawkins, Philip N., additional, Gillmore, Julian D., additional, and Fontana, Marianna, additional

Published
2022
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27. A randomized, multicenter, open-label, blinded end point trial comparing the effects of spironolactone to chlorthalidone on left ventricular mass in patients with early-stage chronic kidney disease: Rationale and design of the SPIRO-CKD trial

Author

Hayer, Manvir K., Edwards, Nicola C., Slinn, Gemma, Moody, William E., Steeds, Rick P., Ferro, Charles J., Price, Anna M., Andujar, Cecilio, Dutton, Mary, Webster, Rachel, Webb, David J., Semple, Scott, MacIntyre, Iain, Melville, Vanessa, Wilkinson, Ian B., Hiemstra, Thomas F., Wheeler, David C., Herrey, Anna, Grant, Margaret, Mehta, Samir, Ives, Natalie, and Townend, Jonathan N.

Published
2017
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32. The importance of pathways to facilitate early diagnosis and treatment of patients with cardiac amyloidosis.

Author

Kwok, Chun Shing and Moody, William E.

Subjects
CARDIAC amyloidosis, MONOCLONAL gammopathies, CARDIAC magnetic resonance imaging, EARLY diagnosis, IMMUNOGLOBULIN light chains, CARDIAC patients, DELAYED diagnosis
Abstract

Cardiac amyloidosis (CA) is a condition caused by extracellular deposition of amyloid fibrils in the heart. It is an underdiagnosed disease entity which can present with a variety of cardiac and non-cardiac manifestations. Diagnosis usually follows an initial suspicion based on clinical evaluation or imaging findings before confirmation with subsequent imaging (echocardiography, cardiac magnetic resonance imaging, 3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy) in combination with biochemical screening for monoclonal dyscrasia (serum free light chains and serum and urine electrophoresis) and/or histology (bone marrow trephine, fat or endomyocardial biopsy). More than 95% of CA can be classified as either amyloid light-chain (AL) CA or amyloid transthyretin (ATTR) CA; these two conditions have very different management strategies. AL-CA, which may be associated with multiple myeloma, can be managed with chemotherapy agents, autologous stem cell transplantation, cardiac transplant and supportive therapies. For ATTR-CA, there is increasing importance in making an early diagnosis because of novel treatments in development, which have transformed this once incurable disease to a potentially treatable disease. Timely diagnosis is crucial as there may only be a small window of opportunity where patients can benefit from treatment beyond which therapies may be less effective. Reviewing the existing patient pathway provides a basis to better understand the complexities of real-world activities which may be important to help reduce missed opportunities related to diagnosis and treatment for patients with CA. With healthcare provider interest in improving the care of patients with CA, the development of an optimal care pathway for the condition may help reduce delays in diagnosis and treatment and thus enhance patient outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Persisting Adverse Ventricular Remodeling in COVID-19 Survivors: A Longitudinal Echocardiographic Study

Author

Moody, William E., primary, Liu, Boyang, additional, Mahmoud-Elsayed, Hani M., additional, Senior, Jonathan, additional, Lalla, Sasha S., additional, Khan-Kheil, Ayisha M., additional, Brown, Stewart, additional, Saif, Abdullah, additional, Moss, Alastair, additional, Bradlow, William M., additional, Khoo, Jeffrey, additional, Ahamed, Mubarak, additional, McAloon, Christopher, additional, Hothi, Sandeep S., additional, and Steeds, Richard P., additional

Published
2021
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45. Changes in Blood Pressure and Arterial Hemodynamics following Living Kidney Donation

Author

Price, Anna M, Greenhall, George HB, Moody, William E, Steeds, Richard P, Mark, Patrick B, Edwards, Nicola C, Hayer, Manvir K, Pickup, Luke C, Radhakrishnan, Ashwin, Law, Jonathan P, Banerjee, Debasish, Campbell, Tunde, Tomson, Charles RV, Cockcroft, John R, Shrestha, Badri, Wilkinson, Ian B, Tomlinson, Laurie A, Ferro, Charles J, Townend, Jonathan N, and EARNEST investigators

Abstract

BACKGROUND AND OBJECTIVES: The Effect of a Reduction in GFR after Nephrectomy on Arterial Stiffness and Central Hemodynamics (EARNEST) study was a multicenter, prospective, controlled study designed to investigate the associations of an isolated reduction in kidney function on BP and arterial hemodynamics. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Prospective living kidney donors and healthy controls who fulfilled criteria for donation were recruited from centers with expertise in vascular research. Participants underwent office and ambulatory BP measurement, assessment of arterial stiffness, and biochemical tests at baseline and 12 months. RESULTS: A total of 469 participants were recruited, and 306 (168 donors and 138 controls) were followed up at 12 months. In the donor group, mean eGFR was 27 ml/min per 1.73 m2 lower than baseline at 12 months. Compared with baseline, at 12 months the mean within-group difference in ambulatory day systolic BP in donors was 0.1 mm Hg (95% confidence interval, -1.7 to 1.9) and 0.6 mm Hg (95% confidence interval, -0.7 to 2.0) in controls. The between-group difference was -0.5 mm Hg (95% confidence interval, -2.8 to 1.7; P=0.62). The mean within-group difference in pulse wave velocity in donors was 0.3 m/s (95% confidence interval, 0.1 to 0.4) and 0.2 m/s (95% confidence interval, -0.0 to 0.4) in controls. The between-group difference was 0.1 m/s (95% confidence interval, -0.2 to 0.3; P=0.49). CONCLUSIONS: Changes in ambulatory peripheral BP and pulse wave velocity in kidney donors at 12 months after nephrectomy were small and not different from controls. CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: NCT01769924 (https://clinicaltrials.gov/ct2/show/NCT01769924).

Published
2020

46. Reference ranges and reproducibility studies for right heart myocardial deformation by feature tracking cardiovascular magnetic resonance imaging

Author

Liu, Boyang, Dardeer, Ahmed M., Moody, William E., Edwards, Nicola C., Hudsmith, Lucy E., and Steeds, Richard P.

Subjects
LVMi, indexed left ventricular mass, SRA′, peak late diastolic strain rate, eGFR, estimated glomerular filtration rate, ESVi, indexed end systolic volume, Medicine and Dentistry, lcsh:Computer applications to medicine. Medical informatics, SRE′, peak early diastolic strain rate, EDVi, indexed end diastolic volume, CMR, cardiac magnetic resonance, EF, ejection fraction, lcsh:R858-859.7, SRS′, peak systolic strain rate, RV, right ventricular, lcsh:Science (General), LV, left ventricular, RV Ell, right ventricular peak longitudinal strain, lcsh:Q1-390
Abstract

Feature tracking of the right heart on cardiac MRI is a novel and promising technique for the measurement of right heart myocardial strain. We present here the reference ranges for right ventricular longitudinal strain and strain rate, as well as peak strain of the right atrium within a cohort of 100 healthy individuals recruited from the UK. We present data on the reproducibility of these feature tracking techniques and explore relationship between strain and baseline demographic parameters.

Published
2018

47. Normal values for myocardial deformation within the right heart measured by feature-tracking cardiovascular magnetic resonance imaging☆

Author

Liu, Boyang, Dardeer, Ahmed M., Moody, William E., Edwards, Nicola C., Hudsmith, Lucy E., and Steeds, Richard P.

Subjects
Cardiovascular magnetic resonance imaging, Adult, Male, Right atrium, Heart Ventricles, Strain rate, Magnetic Resonance Imaging, Cine, Heart, Middle Aged, Reference Standards, Myocardial Contraction, Article, Strain, Cohort Studies, Feature tracking, Young Adult, Ventricular Function, Right, Right ventricle, Humans, Female, Heart Atria, Aged
Abstract

Background Reproducible and repeatable assessment of right heart function is vital for monitoring congenital and acquired heart disease. There is increasing evidence for the additional value of myocardial deformation (strain and strain rate) in determining prognosis. This study aims to determine the reproducibility of deformation analyses in the right heart using cardiovascular magnetic resonance feature tracking (FT-CMR); and to establish normal ranges within an adult population. Methods A cohort of 100 healthy subjects containing 10 males and 10 females from each decade of life between the ages of 20 and 70 without known congenital or acquired cardiovascular disease, hypertension, diabetes, dyslipidaemia or renal, hepatic, haematologic and systemic inflammatory disorders underwent FT-CMR assessment of right ventricular (RV) and right atrial (RA) myocardial strain and strain rate. Results RV longitudinal strain (Ell) was − 21.9 ± 3.24% (FW + S Ell) and − 24.2 ± 3.59% (FW-Ell). Peak systolic strain rate (S′) was − 1.45 ± 0.39 s− 1 (FW + S) and − 1.54 ± 0.41 s− 1 (FW). Early diastolic strain rate (E′) was 1.04 ± 0.26 s− 1 (FW + S) and 1.04 ± 0.33 s− 1 (FW). Late diastolic strain rate (A′) was 0.94 ± 0.33 s− 1 (FW + S) and 1.08 ± 0.33 s− 1 (FW). RA peak strain was − 21.1 ± 3.76%. The intra- and inter-observer ICC for RV Ell (FW + S) was 0.92 and 0.80 respectively, while for RA peak strain was 0.92 and 0.89 respectively. Conclusions Normal values of RV & RA deformation for healthy individuals using FT-CMR are provided with good RV Ell and RA peak strain reproducibility. Strain rate suffered from sub-optimal reproducibility and may not be satisfactory for clinical use.

Published
2018

48. Variation in cardiovascular magnetic resonance myocardial contouring: Insights from an international survey

Author

Moody, William E., Hudsmith, Lucy E., Holloway, Ben, Treibel, Thomas A., Davies, Rhodri, Kozor, Rebecca, Hamilton‐Craig, Christian, Edwards, Nicola C., Bradlow, William M., Moon, James C., and Steeds, Richard P.

Subjects
Male, Myocardium, Image Interpretation, Computer-Assisted, Humans, Female, Heart, Cardiomyopathy, Hypertrophic, Middle Aged, Letter to the Editor, Magnetic Resonance Imaging
Abstract

Level of Evidence: 5 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2019;50:1336–1338.

Published
2019

50. Impact of Right Ventricular Dysfunction on Mortality in Patients Hospitalized With COVID-19, According to Race

Author

Moody, William E., primary, Mahmoud-Elsayed, Hani M., additional, Senior, Jonathan, additional, Gul, Uzma, additional, Khan-Kheil, Ayisha M., additional, Horne, Sebastian, additional, Banerjee, Amitava, additional, Bradlow, William M., additional, Huggett, Robert, additional, Hothi, Sandeep S., additional, Shahid, Muhammad, additional, and Steeds, Richard P., additional

Published
2021
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