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10. Receptor mediated uptake of paclitaxel from a synthetic high density lipoprotein nanocarrier.

Author

Mooberry, Linda K., Nair, Maya, Paranjape, Sulabha, McConathy, Walter J., and Lacko, Andras G.

Subjects
*PACLITAXEL, *CANCER cells, *HIGH density lipoproteins, *NANOPARTICLES, *PROSTATE cancer
Abstract

The purpose of these studies was to determine the mechanism(s) whereby paclitaxel (PTX), is taken up by cancer cells, once encapsulated into synthetic/reconstituted high density lipoprotein (rHDL). The uptake of PTX was found to be facilitated by the scavenger receptor type B-1 (SR-B1) when drug-loaded rHDL particles were incubated with cells that express the SRB1 receptor. Studies with double-labeled, PTX containing rHDL nanoparticles showed that prostate cancer (PC-3) cells incorporated PTX primarily via a selective (SR-B1 type) uptake mechanism. In the presence of a 10-fold excess of plasma HDL, PTX uptake decreased to 30% of the control. These findings suggest that the incorporation of lipophilic drugs by cancer cells from rHDL nanoparticles is facilitated by a receptor mediated (SR-B1) mechanism. [ABSTRACT FROM AUTHOR]

Published
2010
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