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675 results on '"Monzani,Fabio"'

1. Advancing healthcare through thoracic ultrasound research in older patients

Author

Scarlata, Simone, Okoye, Chukwuma, Zotti, Sonia, Lauretani, Fulvio, Nouvenne, Antonio, Cerundolo, Nicoletta, Bruni, Adriana Antonella, Torrini, Monica, Finazzi, Alberto, Mazzarone, Tessa, Lunian, Marco, Zucchini, Irene, Maccioni, Lorenzo, Guarino, Daniela, Fabbri della Faggiola, Silvia, Capacci, Marco, Bianco, Maria Giovanna, Guarona, Guglielmo, Bellelli, Giuseppe, Monzani, Fabio, Virdis, Agostino, Antonelli Incalzi, Raffaele, Ungar, Andrea, and Ticinesi, Andrea

Published
2023
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7. The WSES/SICG/ACOI/SICUT/AcEMC/SIFIPAC guidelines for diagnosis and treatment of acute left colonic diverticulitis in the elderly

Author

Fugazzola, Paola, Ceresoli, Marco, Coccolini, Federico, Gabrielli, Francesco, Puzziello, Alessandro, Monzani, Fabio, Amato, Bruno, Sganga, Gabriele, Sartelli, Massimo, Menichetti, Francesco, Puglisi, Gabriele Adolfo, Tartaglia, Dario, Carcoforo, Paolo, Avenia, Nicola, Kluger, Yoram, Paolillo, Ciro, Zago, Mauro, Leppäniemi, Ari, Tomasoni, Matteo, Cobianchi, Lorenzo, Dal Mas, Francesca, Improta, Mario, Moore, Ernest E., Peitzman, Andrew B., Sugrue, Michael, Agnoletti, Vanni, Fraga, Gustavo P., Weber, Dieter G., Damaskos, Dimitrios, Abu-Zidan, Fikri M., Wani, Imtiaz, Kirkpatrick, Andrew W., Pikoulis, Manos, Pararas, Nikolaos, Tan, Edward, Broek, Richard Ten, Maier, Ronald V., Davies, R. Justin, Kashuk, Jeffry, Shelat, Vishal G., Mefire, Alain Chicom, Augustin, Goran, Magnone, Stefano, Poiasina, Elia, De Simone, Belinda, Chiarugi, Massimo, Biffl, Walt, Baiocchi, Gian Luca, Catena, Fausto, and Ansaloni, Luca

Published
2022
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9. Real‐World Use of Trazodone in Older Persons in Long Term Care Setting: A Retrospective Study.

Author

Coin, Alessandra, Malara, Alba, Noale, Marianna, Trevisan, Caterina, Devita, Maria, Abbatecola, Angela Marie, Gareri, Pietro, Del Signore, Stefania, Bellelli, Giuseppe, Fumagalli, Stefano, Monzani, Fabio, Mossello, Enrico, Volpato, Stefano, Zia, Gianluca, and Antonelli Incalzi, Raffaele

Abstract

Background: Trazodone, an antidepressant drug is also largely used in several medical contexts. Insomnia, behavioral disorders, and anxiety may be underlying symptoms for prescribing trazodone. This cross‐sectional study aims to identify reasons for trazodone prescription, assess the efficacy, as well as identify any related side effects in older persons living in long term care facilities (LTCFs). Methods: Older adults aged ≥ 60 years, at risk of or affected with Covid‐19 and enrolled in the GeroCovid Observational study from LTCFs, and using trazodone were included. A structured questionnaire was administered to treating physicians regarding reasons for trazodone prescription, discontinuation, possible adverse events and benefits. Results: Thirty‐seven out 74 LTCFs participating in both the GeroCovid and GeroCovid Vax studies completed the questionnaire regarding trazodone use. Of the 427 participants included in this study analysis, we found that 43% had diagnoses of dementia and depression, 33% had dementia, no behavioral and psychological symptoms of dementia (BPSD) and no depression, 14% had dementia with BPSD and no depression, and < 11% had only depression. The main reasons for trazodone prescription included agitation, insomnia, depression and anxiety. Trazodone use was reported as partially or totally effective in more than 90% of participants using the drug. Falls were the most frequent adverse event (30% of participants). Conclusions: Our data suggest that trazodone behaves as an eclectic antidepressant that, in the clinical practice, may also be used for BPSD and insomnia, especially in older people with dementia. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Atrial fibrillation and COVID-19 in older patients: how disability contributes to shape the risk profile. An analysis of the GeroCovid registry

Author

Fumagalli, Stefano, Trevisan, Caterina, Del Signore, Susanna, Pelagalli, Giulia, Fumagalli, Carlo, Herbst, Andrea, Volpato, Stefano, Gareri, Pietro, Mossello, Enrico, Malara, Alba, Monzani, Fabio, Okoye, Chukwuma, Coin, Alessandra, Bellelli, Giuseppe, Zia, Gianluca, Ungar, Andrea, Ranhoff, Anette Hylen, and Antonelli Incalzi, Raffaele

Published
2022
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14. Increased Psychological Symptoms and Autonomic Arousal in Patients with Subclinical Hypothyroidism: A Case–Control Study.

Author

Guidotti, Sara, Innocenti, Augusto, Cosentino, Chiara, Monzani, Fabio, Guccini, Irene, and Pruneti, Carlo

Subjects
DELIRIUM, SYMPTOMS, HYPOTHYROIDISM, CASE-control method, PSYCHOLOGICAL well-being, HEART beat, THYROID diseases
Abstract

(1) Background: Subclinical hypothyroidism (SHT) is a condition that has been a subject of controversy in the literature due to its association with psychological and psychiatric symptoms as well as autonomic imbalances. To gain a better understanding of the effects of SHT on patients, a research study has been undertaken to investigate the presence of psychological symptoms and autonomic imbalances in a group of individuals diagnosed with SHT. (2) Methods: In this case–control study, 50 patients diagnosed with SHT who accessed the Department of Endocrinology of the University of Pisa were consecutively recruited. Psychological symptoms were measured through the Crown–Crisp Experiential Index (CCEI), whereas autonomic imbalance was described using the Psychophysiological Stress Profile (PSP), with simultaneous recording of the following psychophysiological parameters: Surface Electromyogram (sEMG), Skin Conductance Level (SCL), heart rate (HR), and peripheral temperature (PT). The patients' values were compared to those of 50 healthy control subjects. (3) Results: The comparison between groups highlighted significant differences in the CCEI and PSP. In particular, patients reported higher rates of psychological symptoms (anxiety, depression, somatic complaints, and hysteria behavior). Significantly higher levels of autonomic arousal were also recorded. More specifically, the sEMG, SCL, HR, and PT values were different between the two groups. (4) Conclusions: The study has confirmed the presence of autonomic hyperarousal in patients diagnosed with subclinical hypothyroidism. This is likely due to the body's attempt to compensate for a general lack of energy by accelerating the autonomic activity. The findings also underline the significance of a comprehensive assessment approach that takes into account various dimensions such as psychological and psychophysical well-being. Such an approach helps in evaluating the impact of subclinical diseases on overall health and well-being. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Drug–Drug Interactions of Hydroxychloroquine and Chloroquine in Older Patients with COVID-19 during the First Pandemic Waves: The GeroCovid Observational Study.

Author

Trevisan, Caterina, Cignarella, Andrea, Grandieri, Andrea, Sergi, Giuseppe, Fumagalli, Stefano, Monzani, Fabio, Okoye, Chukwuma, Bellelli, Giuseppe, Malara, Alba, Gareri, Pietro, Volpato, Stefano, and Antonelli Incalzi, Raffaele

Subjects
COVID-19 pandemic, COVID-19, DRUG interactions, OLDER patients, CHLOROQUINE
Abstract

Objective: Chloroquine (CQ) and hydroxychloroquine (HCQ) were used as off-label treatments for SARS-CoV-2 infection during the first pandemic waves. The urgency of combatting COVID-19 led to the dissemination of medical recommendations with a scarce awareness of possible drug–drug interactions. This issue primarily concerned people already taking multiple medications, such as older individuals. We estimated the prevalence of drug interactions with CQ or HCQ in COVID-19 inpatients during the first pandemic waves and their possible association with hospitalization-related outcomes. Methods: This study considers 487 patients aged ≥60, hospitalized for COVID-19 from March to December 2020, and treated with CQ or HCQ. Data on acute and chronic therapies and hospitalization length and outcomes were derived from medical records. The presence of drugs potentially interacting with CQ and HCQ was identified based on published literature and drug databases. Results: In our sample (mean age 77.1 years, 47.8% females), 255 (52.4%) patients presented with one drug interaction with CQ or HCQ, and 114 (23.4%) had more than two interactions. The most frequent drugs potentially interacting with CQ or HCQ were lopinavir/ritonavir (50.4%), azithromycin (47.2%), tocilizumab (15.4%), levofloxacin (8.7%), clarithromycin (6.0%), amlodipine (3.3%), and trazodone (2.4%). No substantial differences in the duration and outcomes of the hospitalization emerged as a function of the presence of drug–drug interactions. Conclusions: Many older patients prescribed with CQ or HCQ, which have lately proved ineffective against COVID-19, were exposed to the risk of drug–drug interaction. This underlines that medical recommendations should undergo careful peer review before being widely disseminated, even in emergencies like a pandemic. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Understanding Factors Associated With Psychomotor Subtypes of Delirium in Older Inpatients With Dementia

Author

Rispoli, Vincenzo, Malara, Alba, Spadea, Fausto, Di Cello, Serena, Ceravolo, Francesco, Fabiano, Francesco, Chiaradia, Giuseppe, Gabriele, Amedeo, Lenino, Peluso, Andrea, Taristano, Settembrini, Vincenzo, Capomolla, Domenico, Citrino, Antonella, Scriva, Antonietta, Bruno, Irene, Secchi, Roberto, De Martino, Eugenio, Muccinelli, Roberto, Lupi, Gerardo, Paonessa, Patrizio, Fabbri, Andrea, Passuti, Maria Teresa, Castellari, Sofia, Po, Andrea, Gaggioli, Guido, Varesi, Massimo, Moneti, Paolo, Capurso, Sebastiano, Latini, Vincenzo, Ghidotti, Stefano, Riccardelli, Francesco, Macchi, Maurizio, Rigo, Rosaria, Claudio, Pascale, Angelo, Bosio, Flavio, Cerrato, Benedetta, Bardelli, Boffelli, Stefano, Cassinadri, Angela, Franzoni, Simone, Spazzini, Elena, Andretto, Daniela, Tonini, Gabriele, Andreani, Laura, Coralli, Mirco, Balotta, Antonio, Cancelliere, Roberto, Ballardini, Giorgio, Simoncelli, Margherita, Mancini, Annarita, Strazzacapa, Mara, Fabio, Stefano, De Filippi, Francesco, Giudice, Chiara, Dentizzi, Cosimo, Azzini, Margherita, Cazzadori, Marco, Mastroeni, Valeria, Bertassello, Paolo, Claudia Benati, Helena Santana, Nesta, Elisa, Tobaldini, Chiara, Guerini, Fabio, Elena, Tambara, Mombelloni, Paolo, Fontanini, Fulvio, Gabriella, Lassa, Pizzorni, Crosio, Oliverio, Martina, Del Grosso, Luciano Luca, Giavedoni, Cristina, Bidoli, Giuliano, Mazzei, Bruno, Corsonello, Andrea, Fusco, Sergio, Vena, Silvio, De Vuono, Tommaso, Maiuri, Giorgio, Luca, Fimognari Filippo, Andrea, Arone, Giovanni, Sgrò, Rossella, Nicolazzo, Castegnaro, Eugenio, De Rosa, Salvatore, Sechi, Rossella Bazzano, Benvenuti, Enrico, Del Lungo, Ilaria, Giardini, Sante, Giulietti, Chiara, Mauro, Di Bari, Eleonora, Barghini, Martina, Paoli, Irene, Fiordelli, Riccardo, Barucci, Federica, Sgrilli, Ilaria, Del Lungo, Bertoletti, Erik, D'Amico, Ferdinando, Caronzolo, Francesco, Grippa, Alessandro, Lombardo, Giuseppina, Pipicella, Tiziana, Antonino, Saitta, Francesco, Corica, Valeria, Prestipino Giarritta, Daniela, Larosa, Domenico, Cucinotta, Giorgio, Basile, March, Albert, Nitti, Maria Teresa, Felici, Alessandro, Pavan, Silvia, Piazzani, Fabrizio, Lunelli, Alessandra, Dimori, Sergio, Margotta, Alessandro, Soglia, Tiziano, Postacchini, Demetrio, Brunelli, Roberto, Santini, Silvia, Francavilla, Monia, Macchiati, Ilenia, Sorvillo, Francesca, Giuli, Cinzia, Mecocci, Patrizia, Longo, Annalisa, Perticone, Francesco, Addesi, Desireè, Rosa, Paola Cerra, Bencardino, Giuseppe, Falbo, Tania, Grillo, Nadia, Marco, Filice, Mirella, Flippo, Fantò, Fausto, Isaia, Gianluca, Pezzilli, Stella, Bergamo, Daniele, Furno, Elisabetta, Rrodhe, Sokol, Lucarini, Simonetta, Dijk, Babette, Dall'Acqua, Francesca, Cappelletto, Francesco, Calvani, Donatella, Becheri, Dimitri, Giuseppe, Mottino, Costanza, Mitidieri, Vito, Antonio, Francesca, Bartalucci, Magherini, Lorenza, Novella, Malin, Franca, Boni, Lucia Gambardella, Paoli Martina, Valente, Carlo, Ilaria, Bracali, Alice, Foschini, Bo, Mario, Porrino, Paola, Ceci, Giacomo, Giuliana, Bottignole, Michela, Tibaldi, Eleonora, Coppo, Ettore, Evaristo, Camellini, Cinzia, Servello, Adriana, Grassi, Alessandro, Rozzini, Renzo, Tironi, Sara, Grassi, Maria Grazia, Troisi, Elio, Carlo, Caltagirone, Simona Gabriella, Di Santo, Flaminia, Franchini, Federica, Ratto, Beatrice, Pavoni, Sofia, Toniolo, Gabutto, Anna, Quazzo, Loredana, Rosatello, Annalisa, Suraci, Domenico, Tagliabue, Benedetta, Perrone, Chiara, Ferrara, Lucia, Castagna, Alberto, Tremolada, Maria Luisa, Giuseppe, Castoldi, Stefano, Barbero, Davide, Oltramonti, Piano, Simonetta, Serviddio, Gaetano, Lo Buglio, Aurelio, Gurrera, Tiziana, Merlo, Valeria, Rovai, Carla, Cotroneo, Antonino Maria, Carlucci, Rosaria, Abbaldo, Anna, Monzani, Fabio, Qasem, Ahmad Amedeo, Bini, Giacomo, Tafuto, Silvia, Galli, Giovanni, Bruni, Amalia Cecilia, Mancuso, Giovanna, Mancuso, Gerardo, Calipari, Daniela, Giuseppe Massimiliano, De Luca, Bernardini, Bruno, Corsini, Carla, Michele, Ciccarelli, Sara, Dal Farra, Cagnin, Annachiara, Fragiacomo, Federica, Pompanin, Sara, Piero, Amodio, Marco, Cagnin, Zurlo, Amedeo, Guerra, Gianluca, Pala, Marco, Menozzi, Luca, Gatti, Chiara Delli, Magon, Stefania, Roberto, Manfredini, Alfredo, De Giorgi, Fabio, Fabbian, Ruana, Tiseo, Elisa, Misurati, Benedetta, Boari, Christian, Molino, Marco, Pala, Massimo, Gallerani, Di Francesco, Vincenzo, Faccioli, Silvia, Pellizzari, Luca, Giorgia, Fontana, Barbagallo, Giuseppe, Lunardelli, Maria Lia, Martini, Emilio, Ferrari, Eleonora, Macchiarulo, Maria, Corneli, Maria, Bacci, Monica, Battaglia, Giuseppe, Anastasio, Luigi, Lo Storto, Mario Sostene, Seresin, Chiara, Simonato, Matteo, Loreggian, Michele, Cestonaro, Fausta, Durando, Mario, Latella, Raffaele, Mazzoleni, Marta, Russo, Giuseppe, Ponte, Martino, Valchera, Alessandro, Salustri, Giuseppe, Petritola, Donatella, Costa, Alfredo, Sinforiani, Elena, Cotta, Matteo Ramusino, Pizio, Renato Nicola, Cester, Alberto, Formilan, Marino, Pietro, Bonometto, Carbone, Pasqualina, Cazzaniga, Ilaria, Appollonio, Ildebrando, Cereda, Diletta, Stabile, Andrea, Xhani, Rubjona, Acampora, Roberto, Tremolizzo, Lucio, Federico, Pieruzzi, Antonio, Ciaccio, Valerio, Pontecorvi, Cesare, Burti, Zhirajr, Mokini, Giovanni, Vitale, Maria, Amigoni, Mariaelena, Sparacino, Bottacchi, Edo, Bucciantini, Elisabetta, Di Giovanni, Marco, Franchi, Fabrizio, Lucchetti, Lucio, Mariani, Claudio, Grande, Giulia, Rapazzini, Piero, Marco, Mauri, Romanelli, Giuseppe, Marengoni, Alessandra, Franco, Nicosia, Alessio, Margola, Stefano, Bonardelli, Nicola, Latronico, Laura, Porcella, Nazario, Portolani, Carlo, Concoreggi, Chiara, Grassini, Soccorso, Pronto, Andrea, Salvi, Luca, Bianchetti, Francesca, Spagnoli, Roberto, Apuzzo, Marco, Fontanella, Anna, Ceraso, Francesco, Castelli, Fugazza, Luciano, Guerrini, Chiara, De Paduanis, Giovanna, Iallonardo, Lucia, Palumbo, Pasquale, Zuliani, Giovanni, Ortolani, Beatrice, Capatti, Eleonora, Soavi, Cecilia, Bianchi, Lara, Francesconi, Daniela, Miselli, Agata, Gloria, Brombo, Tommaso, Romagnoli, Chiara, Pazzaglini, Agata, Miselli Maria, Marco, Dall'Agata, Luca, Menozzi, Gianluca, Guerra, Suardi, Teresa, Mazzone, Andrea, Zaccarini, Cinzia, Manuela, Riva, Mirra, Gianluca, Muti, Ettore, Bottura, Renato, Gianpaolo, Moretti, Secreto, Piero, Bisio, Erika, Cecchettani, Marco, Naldi, Tamara, Pallavicino, Alessandra, Pugliese, Michela, Iozzo, Rosaria Cosima, Grassi, Guido, Michele, Bombelli, Raffaella, Dell'Oro, Fosca, Quarti Trevano, Giorgio, Giussani Carlo, Giovanni, Paternò, Ernesto, Contro, Mannironi, Antonio, Giorli, Elisa, Oberti, Sara, Fierro, Brigida, Piccoli, Tommaso, Giacalone, Fabio, Mandas, Antonella, Serchisu, Luca, Costaggiu, Diego, Pinna, Elisa, Orrù, Francesca, Mannai, Martina, Cordioli, Zeno, Pelizzari, Luca, Turcato, Emanuela, Arduini, Pietro, Cacace, Carlo, Chiloiro, Roberta, Cimino, Rosella, Ruberto, Carmen, Giovanni, Ruotolo, Pietro, Gareri, Laura, Greco, Alberto, Castagna, Carmen, Ruberto, Santo, Pierluigi Dal, Andriolli, Antonino, Burattin, Giuseppe, Rossi, Laura, Andreolli Antonino, Cervati Giovanna, Giuseppe, Catalano, Tezza, Fabiana, Maddalena, Pizzardini, Laura, Stievano, Crippa, Patrizia, Aloisio, Paola, Di Monda, Tiziana, Malighetti, Alessandro, Galbassini, Gloria, Salutis, Domus, Ivaldi, Claudio, Russo, Anna Maria, Bennati, Ettore, Pino, Elisabetta, Zavarise, Gianmaria, Pesci, Alberto, Suigo, Giulia, Faverio, Paola, Andrea, Gori, Sabrina, Perego, Zanasi, Massimo, Moniello, Giovanni, Rostagno, Carlo, Cartei, Alessandro, Polidori, Gianluca, Ungar, Andrea, Melis, Maria Ramona, Martellini, Eleonora, Enrico, Mossello, Monica, Torrini, Antonella, Giordano, Giovanna, Leone, Migliorini, Marta, Caramelli, Francesca, Battiston, Bruno, Berardino, Maurizio, Cavallo, Simona, Alessandro, Massè, Anna, Santoro, Lombardi, Bruna, D'Ippolito, Pierpaolo, Furini, Angela, Villani, Daniele, Clara, Raimondi, Guarneri, Massimo, Paolucci, Stefano, Bassi, Andrea, Coiro, Paola, De Angelis, Domenico, Morone, Giovanni, Venturiero, Vincenzo, Palleschi, Lorenzo, Raganato, Paolo, Di Niro, Giuseppina, Rosa, Casini Anna, Loredana, Bove, Imoscopi, Alessandra, Isaia, Giancarlo, Tibaldi, V., Bottignole G, G., Calvi, E., Clementi, C., Zanocchi, M., Agosta, L., Nortarelli, Antonella, Provenzano, Giuseppe, Mari, Daniela, Romano, Federica Ylenia, Rosini, Francesca, Mansi, Marta, Rossi, Silvia, Geriatria, Alex Riccardelli, Inzaghi, Lorenzo, Bonini, Giulia, Rossi, Paolo, Potena, Alfredo, Lichii, Mihaela, Candiani, Tiziana, Grimaldi, William, Bertani, Emiliano, Alessandra, Porta, Calogero, Pietro, Pinto, Daniela, Bernardi, Roberto, Nicolino, Francesco, Galetti, Caterina, Gianstefani, Alice, Giulia, Corvalli, Lorenzo, Mulazzani, Odetti, Patrizio, Monacelli, Fiammetta, Prefumo, Matteo, Fiammetta, Monacelli, Canepa, Marta, Minaglia, Cecilia, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Prestano, Raffaele, Dalise, Anna Maria, Barra, Davide, Bosco, Livio Dal, Asprinio, Vincenzo, Dallape, Luciana, Perina, Elisa, Incalzi, Raffaele Antonelli, Bartoli, Isaura Rossi, Pluderi, Alice, Maina, Antonella, Pecoraro, Elisabetta, Sciarra, Michela, Prudente, Angela, Paola, Maina, Francesca, Mete, Manuel, Ventura, Luisella, Cesari, Maria, Pernigotti Luigi, Tina, Santangelo, Benini, Lucia, Levato, Francesco, Mhiuta, Victor, Alius, Florin, Davidoaia, Diana, Giardini, Vittorio, Garancini, Mattia, Bellamoli, Claudio, Terranova, Luciano, Bozzini, Claudia, Tosoni, Paolo, Provoli, Emma, Cascone, Luisa, Dioli, Andrea, Ferrarin, Gianfranco, Bucci, Adelmo, Bua, Guido, Fenu, Sara, Bianchi, Giovanna, Casella, Silvia, Romano, Valentina, Maurizio, Poli, Mascherona, Ilenia, Belotti, Gloria, Cavaliere, Sabina, Cuni, Estella, Merciuc, Nina, Oberti, Rosella, Veneziani, Silvia, Capoferri, Emanuela, De Bernardi, Elisabetta, Colombo, Katia, Bravi, Marco, Nicoletta, Negrinotti, D'Arcangelo, Paolo, Montenegro, Nicola, Montanari, Roberto, Lamanna, Pierpaolo, Gasperini, Beatrice, Isabella, Montesi, Stefania, Diotallevi, Gaia, Altobelli, Filippo, Calcinaro, Palamà, Chiara, Di Emidio, Chiara, Scarpini, Elio, Arighi, Andrea, Fumagalli, Giorgio, Basilico, Paola, De Amicis Margherita, Migone, Marta, Mancarella, Diletta, Maira, Granata, Antonino, Ranalli, Claudia, Cammilli, Alessandra, Cavallini, Maria Chiara, Tricca, Manola, Natella, Daniela, Gabbani, Luciano, Tesi, Francesca, Martella, Letizia, Imbrici, Rosalba, Guerrini, Gianbattista, Scotuzzi, Anna Maria, Sozzi, Ferdinando, Valenti, Luigi, Chiarello, Antonino, Monia, Monella, Pilotto, Alberto, Prete, Camilla, Senesi, Barbara, Meta, Anna Cristina, Pendenza, Enrico, Pasqualetti, Giuseppe, Polini, Antonio, Tognini, Sara, Ballino, Elena, Cherubini, Antonio, Dell'Aquila, Giuseppina, Gasparrini, Pina Maria, Marotti, Elisabetta, Migale, Monica, Scrimieri, Antonia, Falsetti, Lorenzo, Salvi, Aldo, Toigo, Gabriele, Ceschia, Giuliano, Rosso, Alessia, Tongiorgi, Chiara, Scarpa, Cristina, Maurizio, Pacchioni, De Dominicis, Luigino, Pucci, Eugenio, Renzi, Sara, Cartechini, Elisabetta, Tomassini, Pia Francesca, Del Gobbo, Maurizio, Ugenti, Francesca, Romeo, Pasquale, Nardelli, Anna, Lauretani, Fulvio, Visioli, Sandra, Montanari, Ilaria, Ermini, Francesca, Giordano, Antonio, Pigato, Giorgio, Simeone, Emilio, Barbujani, Mario, Giampieri, Marina, Amoruso, Raffaele, Piccinini, Maristella, Ferrari, Camilla, Gambetti, Claudio, Sfrappini, Mario, Semeraro, Letizia, Striuli, Rinaldo, Mariani, Claudia, Pelliccioni, Giuseppe, Marinelli, Donatella, Fabi, Katia, Rossi, Tommaso, Pesallaccia, Martina, Sabbatini, Debora, Gobbi, Beatrice, Cerqua, Raffaella, Tagliani, Giancarla, Schlauser, Elena, Caser, Luciano, Caramello, Elisa, Sandigliano, Franca, Rosso, Giorgio, Ferrari, Alberto, Bendini, Chiara, Luisa, Davoli Maria, Casella, Monica, Prampolini, Raffaella, Scevola, Moreno, Vitale, Enrico, Roberto, Brugiolo, Carlo, Fagherazzi, Sergio, Fusco, Alberto, Scarpa, Daniela, Zara, Giulia, Bertozzo, Serena, Granziera, Michele, Barazzuol, Maugeri, Domenico, Sorace, Rosaria, Anzaldi, Massimiliano, De Gesu, Roberto, Morrone, Giuseppe, Davolio, Federica, Fabbo, Andrea, Palmieri, Marina, Zoli, Marco, Forti, Paola, Pirazzoli, Luca, Fabbri, Elisa, Terenzi, Laura, Bergolari, Federica, Wenter, Christian, Ruffini, Ingrid, Insam, Miriam, Abraham, Elisabeth, Kirchlechner, Christine, Cucinotta, Domenico, Antonino, Lasco, Basile, Giorgio, Grazia, Arena Maria, Parise, Pasquale, Boccali, Andrea, Amici, Serena, Gambacorta, Maurizia, Lasagni, Anna, Lovati, Roberto, Giovinazzo, Francesca, Kimak, Elzbieta, Zappa, Paolo, Medici, Francesco, Lo Castro, Marika, Mauro, Flavia, De Luca, Alessandro, Sancesario, Giuseppe, Martorana, Alessandro, Scaricamazza, Beatrice, Toniolo, Sofia, Di Lorenzo, Francesco, Liguori, Claudio, Lasco, Antonino, Vita, Natale, Giomi, Mirna, Forte, Floriana, Padovani, Alessandro, Rozzini, Luca, Ceraso, Anna, Salvatore, Caratozzolo, Cottino, Maria, Vitali, Silvia, Marelli, Eleonora, Tripi, Gabriele, Miceli, Salvatore, Urso, Giovanni, Grioni, Giuseppe, Vezzadini, Giuliana, Misaggi, Giulia, Forlani, Chiara, Avanzi, Stefano, Serena, Saulle, Claudia, Casarini, Marilena, Viggiano, Alberto, Luisa, Diego, Ghianda, Alessandro, Giordano, Iemolo, Francesco, Giordano, Antonello, Sanzaro, Enzo, D'Asta, Gabriele, Proietto, Maria, Carnemolla, Anna, Razza, Grazia, Spadaro, Daniela, Bertolotti, Marco, Mussi, Chiara, Neviani, Francesca, Roberto, Chiesa, Valentina, Guerzoni, Linda, Morselli, Francesca, Venturelli, Tarozzi, Adriano, Balestri, Francesca, Mannarino, Giulio, Bigolari, Michela, Natale, Alessia, Grassi, Simona, Bottaro, Cinzia, Stefanelli, Sara, Bovone, Ugo, Tortorolo, Umberto, Quadri, Roberto, Leone, Giuseppe, Ponzetto, Maria, Frasson, Paola, Annoni, Giorgio, Bellelli, Giuseppe, Bruni, Adriana, Confalonieri, Roberto, Corsi, Maurizio, Moretti, Daniela, Teruzzi, Fabiola, Umidi, Simona, Mazzola, Paolo, Perego, Sabrina, Persico, Ilaria, Olivieri, Giulia, Bonfanti, Alessandra, Hajnalka, Szabò, Galeazzi, Marianna, Massariello, Francesca, Anzuini, Alessandra, Caffarra, Paolo, Barocco, Federica, Spallazzi, Marco, Paolo, Ceda Gian, Simonetta, Morganti, Andrea, Artoni, Chioatto, Paolo, Bortolamei, Sandra, Soattin, Lucia, Ruotolo, Giovanni, Beneamino, Borelli, Giuseppe, Barilaro, Bertazzoli, Marco, Rota, Elisabetta, Adobati, Annamaria, Scarpa, Alberto, Granziera, Serena, Zuccher, Paola, Fabbro, Angela Dal, Zara, Daniela, Lo Nigro, Ambra, Franchetti, Lorena, Toniolo, Marika, Marcuzzo, Cinzia, Rollone, Marco, Guerriero, Fabio, Sgarlata, Carmelo, Massè, Alessandro, Zatti, Giovanni, Piatti, Massimiliano, Graci, Jole, Benati, Giuseppe, Boschi, Federica, Biondi, Mario, Fiumi, Nicoletta, Erika, Tamburini, Locatelli, Sergio Mario, Mauri, Sabrina, Beretta, Mauro, Margheritis, Laura, Desideri, Giovanbattista, Liberatore, Ester, Carucci, Anna Cecilia, Bonino, Paolo, Caput, Margherita, Antonietti, Maria Paola, Polistena, Giuseppe, De la Pierre, Franz, Mari, Marcello, Massignani, Paola, Tombesi, Fabio, Selvaggio, Fabio, Verbo, Brunella, Bodoni, Paolo, Marchionni, Niccolò, Mossello, Enrico, Sabatini, Tony, Mussio, Eleonora, Magni, Eugenio, Bianchetti, Angelo, Crucitti, Andrea, Titoldini, Giulia, Cossu, Beatrice, Fascendini, Sara, Licini, Cristina, Tomasoni, Angela, Calderazzo, Massimo, Daniela, Tropiano, Valentina, Laganà, Melotti, Rita Maria, Lilli, Albina, Buda, Simona, Adversi, Marco, Noro, Gabriele, Turco, Renato, Ubezio, M Chiara, Mantovani, Anna Roberta, Viola, Maria Cristina, Serrati, Carlo, Pretta, Stefano, Infante, Maria, Gentile, Simona, Morandi, Alessandro, D'Ambrosio, Viviana, Mazzanti, Paolo, Brambilla, Cristina, Sportelli, Silvia, Platto, Caterina, Faraci, Bianca, Quattrocchi, Daniela, Pernigotti, Luigi Maria, Pisu, Cristina, Sicuro, Francesca, Zagnoni, Piergiuseppe, Ghiglia, Stefania, Mosca, Massimiliano, Corazzin, Ileana, Deola, Mariangela, Biagini, Carlo Adriano, Bencini, Francesca, Cantini, Claudia, Tonon, Elisabetta, Pierinelli, Silvia, Onofrj, Marco, Thomas, Astrid, Filomena, Borbone, Bonanni, Laura, Gabriella, Cacchiò, Comi, Giancarlo, Magnani, Giuseppe, Santangelo, Roberto, Mazzeo, Salvatore, Giuseppe, Magnani, Francesca, Caso, Giordano, Cecchetti, Roberto, Sant'Angelo, Barbieri, Cristina, Giroldi, Liviana, Bandini, Fabio, Masina, Marco, Malservisi, Simona, Cicognani, Annalena, Ricca, Laura, Piccininni, Maristella, Tassinari, Tiziana, Brogi, Davide, Sugo, Annalisa, Alessandra, Filippi, Sonia, Manfredi, Valerio, Vanni, Andrea, Usai Carlo, Enrico, Colombo, Vera, Renna Francesca, Assunta, Sauchella, Gianmaria, Zavarise, Mauro, Prete, Pietro, Bisagni, Roberto, Masini, Salvatore, Carrabetta, Barone, Antonella, Razzano, Monica, Giuseppe, Imperoli, Angela, Bini, Francesco, Serra, Valeria, D'Agostino, Federico, Gianolla, Lucia, Pietrangeli, Antonella, Velardi, Elisabetta, Di Cello, Cristina, Rosati, Nadia, Casali, Maria, Sessa, Luciano, Abruzzi, Chiara, Costanzi, Bini, Paolo, Pignata, Michele, Enrico, Buonagurio, Maria, Vollery, Giovanni, Carrieri, Giorgio, Cioni, Andrea, Toschi, Marco, Metra, Piera, Ranieri, Alberto, Zucchelli, Ceccon, Anna, Magrin, Laura, Marin, Sara, Barbara, Sofia, Marco, Masina, Laura, Ghedini, Matteo, Moroni, Marco, Paragona, Caterina, Pallotti Maria, Carla, Rota, Federica, Gottardi, Clara, Tomasoni, Melania, Cappuccio, Giampaolo, Bonini, Stefano, Guerini, Valeria, Guerini, Lucia, Merla, Giovambattista, Desideri, Ester, Liberatore, Cecilia, Carucci Anna, Maurizio, Tovaglieri, Vera, Renna Frandesca, Nadia, Bongiorni, Grillo, Antonio, Arenare, Francesca, Tonino, Mineo, David, Kanah, Giorgio, Vianello Piero, Ubaldo, Balducci, Vincenzo, Sidoti, Stefano, Montanari, Marino, Formilan, Busonera Flavio, Murelli Teodolindo, Paolo, Albanese, Monica, Maselli, Francesco, Bolzetta, Roberto, Fabris, Paolo, Bonino, DuranteMangoni, Emanuele, Testoni, Michela, Fabio, Di Stefano, Loredana, Seccia, Valeria, Sonzini, Fabiano, Maria, Annabella, Di Giorgio, Salvatore, De Cosmo, Greco, Antonio, Grazia, D'Onofrio, Daniele, Sancarlo, Gianluca, Resta, Renzo, Girardello, Sergio, Minervini, Morena, Boni, Vitali, Mariagrazia, Marina, Pizzoni, Paolo, De Colle, Cristina, Scarpa, Alessandra, Frattola, Orlandini, Francesco, La Regina, Micaela, Desirée, Addesi, Mirella, Filippo, Mario, Bo, Paola, Porrino, Padulo, Filomena, Cristina, Margheriti, Dario, Rolano, Giancarla, Moscatelli, Guido, Radaelli, Elena, Montini, Prete, Cosimo, Marileda, Novello, Igor, Bramuzzo, Nicole, Bertin, Elena, Rinaldo, Paolillo, Ciro, Riccardi, Angela, Claudia, Benedetti, Barbara, Rizzi, Francesca, Montagna, Silvia, Vitali, Chiara, Cutaia, Oliver, Baca, Mauro, Colombo, Eleonora, Marelli, Giuseppe, Procino, Rosaria, Tararà, Maria, Cottino, Davide, Dell'Acqua, Stefania, Cislaghi, Marco, Cairati, Massimo, Porta, Luca, Scaglione, Martina, De Feo, Paola, Vertolli, Lia, Salvati, Sandro, Cinotti, Valentina, De Santis, Erminia, Biferi, Paola, Cheli, Romina, Rebizzo, Minisola, Salvatore, Luciano, Colangelo, Pasquale, Abete, Ilaria, Liguori, Francesca, Curcio, Guglielmo, Spassini, Marco, Engheben, Sara, Rotunno, Paola, Arosio, Claudio, Angelini, Francesco, Reggiani, Alessandro, Cappelli, Simona, Marcheselli, Lara, Fratticci, Paola, Ranzani, Simonetta, Cesarini, Antonella, Cerini, Generoso, Uomo, Fernando, Gallucci, Giuliano, Ceschia, Emanuela, Serra, Mariolina, Sola, Alessandro, Delitala, Chiara, Pes, Giulia, Lobianco, Alessandro, Giani, Famularo, Simone, Sandini, Marta, Pinotti, Enrico, Gianotti, Luca, Antonella, Battuello, Giulia, Pintore, Sante, Giardini, Rossi, Andrea, Rubele, Sofia, Sant, Selena, Marco, Vignati, Danila, Clerici, Fabio, Rosa, Bandirali, Maria Pia, Nicoletta, Cattaneo, Laura, Boffi, Paolo, Tosoni, Luciano, Terranova, Leonello, Avalli, Margherita, Scanziani, Stefania, De Notaris, Pierluigi, Del Santo, Laura, Rossi, Fabiana, Tezza, Giovanna, Cervati, Antonino, Andreolli, Felice, Catalano, Giuseppe, Burattin, Danilo, Fogli, Giovanna, Di Bella, Francesco, Landi, Salini, Sara, Angela, Brunetti Maria, Giorgetta, Cappa, Giovanni, Galvagno, Paola, Cena, Gerardo, Bruno, Silvio, Raspo, Letizia, Semeraro, Sabrina, Pedrotti, Davide, Barra, Rosaria, Rizzo Maria, Maria, Dalise Anna, Raffaele, Prestano, Palmieri, Vincenzo Ostilio, Palasciano, Giuseppe, Belfiore, Anna, Portincasa, Piero, Carlo, Sabbà, Vincenzo, Solfrizzi, Alessia, D'introno, Valiani, Vincenzo, Carolina, Bologna, Tiziana, Ciarambino, Paola, Turelli, Ugo, Pazzaglia, Federica, Rodella, Giacomo, Piana, Castellano, Maurizio, Anna, Garelli, Elisa, Casella, Federica, Campana, Antonietta, Coschignano Maria, Luigi, Marinangeli, Fabio, Lorico, Salvatore, Bazzano, Giuseppe, Menculini, Gelosa, Giorgio, Viviana, Ambrogio Teresa, Piras, Valentina, Andrea, Ciricugno, Alessandra, Bollari, Coen, Daniele, Magliola, Renata, Milanesio, Deborah, Muzzulini, Carlo Lorenzo, Paolo, Fogliacco, Marinella, Turla, Sofia, Cotelli Maria, Marta, Bianchi, Siano, Pietro, Capo, Giuseppe, Napoletano, Rosa, Cecilia, Politi, Mancini, Concetta, Del Buono, Corrado, De Bartolomeo, Giuseppe, Addolorata, Martinelli, Carmen, Cefalogli, Roberto, Cozzi, Giovanni, Virtuani Angelo, Moschettini, Gianfilippo, Franco, Mastroianni, Daniela, Roglia, D'Amico, Gabriella, Mirella, Palella, Endrizzi, Cristina, Trotta, Lucia, Ciarambino, Tiziana, Orazio, Zanetti, Emanuela, Terazzi, Marta, Sacchetti, Thomas, Fleetwood, Giacomo, Tondo, Ignazio, Di Fazio, Andrea, Bruni, Giuseppe, Orsitto, Emanuela, Fabbro, Serena, Amici, Elena, D'Imporzano, Anna, Casanova, Serena, Bertolio, Erika, Nervo, Roberto, Silvestri, Elena, Semproni, Manuela, Pintus, Francesca, Aloe, Angelo, Tagliaccica, Zambon, Antonella, and Di Santo, Simona G.

Published
2020
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18. Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age

Author

Lisco, Giuseppe, primary, Disoteo, Olga Eugenia, additional, De Tullio, Anna, additional, De Geronimo, Vincenzo, additional, Giagulli, Vito Angelo, additional, Monzani, Fabio, additional, Jirillo, Emilio, additional, Cozzi, Renato, additional, Guastamacchia, Edoardo, additional, De Pergola, Giovanni, additional, and Triggiani, Vincenzo, additional

Published
2023
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19. Association between antipsychotics and all‐cause mortality in elderly patients diagnosed with dementia with different patterns of BPSD

Author

Rogani, Sara, primary, Calsolaro, Valeria, additional, Coppini, Giulia, additional, Lemmi, Bianca, additional, Taverni, Irene, additional, Bianchi, Elena, additional, Pullia, Rosanna, additional, Carlo, Ludovica Di, additional, Okoye, Chukwuma, additional, Virdis, Agostino, additional, and Monzani, Fabio, additional

Published
2023
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22. Frailty, psychological well‐being, and social isolation in older adults with cognitive impairment during the SARS‐CoV‐2 pandemic: data from the GeroCovid initiative

Author

Terziotti, Camilla, primary, Ceolin, Chiara, additional, Devita, Maria, additional, Raffaelli, Cecilia, additional, Antenucci, Sara, additional, Bazzano, Salvatore, additional, Capasso, Andrea, additional, Castellino, Manuela, additional, Signore, Stefania Del, additional, Lubian, Francesca, additional, Maiotti, Mariangela, additional, Monacelli, Fiammetta, additional, Mormile, Maria Teresa, additional, Sgarito, Claudia, additional, Vella, Filomena, additional, Sergi, Giuseppe, additional, Gareri, Pietro, additional, Trevisan, Caterina, additional, Bellio, Andrea, additional, Fini, Filippo, additional, Malara, Alba, additional, Mossello, Enrico, additional, Fumagalli, Stefano, additional, Volpato, Stefano, additional, Monzani, Fabio, additional, Bellelli, Giuseppe, additional, Zia, Gianluca, additional, Incalzi, Raffaele Antonelli, additional, and Coin, Alessandra, additional

Published
2023
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26. Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age.

Author

Lisco, Giuseppe, Disoteo, Olga Eugenia, De Tullio, Anna, De Geronimo, Vincenzo, Giagulli, Vito Angelo, Monzani, Fabio, Jirillo, Emilio, Cozzi, Renato, Guastamacchia, Edoardo, De Pergola, Giovanni, and Triggiani, Vincenzo

Abstract

Sarcopenia is an age-related clinical complaint characterized by the progressive deterioration of skeletal muscle mass and strength over time. Type 2 diabetes (T2D) is associated with faster and more relevant skeletal muscle impairment. Both conditions influence each other, leading to negative consequences on glycemic control, cardiovascular risk, general health status, risk of falls, frailty, overall quality of life, and mortality. PubMed/Medline, Scopus, Web of Science, and Google Scholar were searched for research articles, scientific reports, observational studies, clinical trials, narrative and systematic reviews, and meta-analyses to review the evidence on the pathophysiology of di-abetes-induced sarcopenia, its relevance in terms of glucose control and diabetes-related outcomes, and diagnostic and therapeutic challenges. The review comprehensively addresses key elements for the clinical definition and diagnostic criteria of sarcopenia, the pathophysiological correlation be-tween T2D, sarcopenia, and related outcomes, a critical review of the role of antihyperglycemic treatment on skeletal muscle health, and perspectives on the role of specific treatment targeting myokine signaling pathways involved in glucose control and the regulation of skeletal muscle metabolism and trophism. Prompt diagnosis and adequate management, including lifestyle inter-vention, health diet programs, micronutrient supplementation, physical exercise, and pharmaco-logical treatment, are needed to prevent or delay skeletal muscle deterioration in T2D. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Promoting and Building Long-Term Care Health Research Networks: GeroCovid Observational and Gerocovid Vax Initiatives

Author

Abbatecola, Angela Marie, primary, Abbatecola, Angela Marie, additional, Incalzi, Raffaele Antonelli, additional, Bellelli, Giuseppe, additional, Borselli, Gilda, additional, Cafariello, Carmine, additional, Coin, Alessandra, additional, Del Signore, Stefania, additional, Del Signore, Susanna, additional, Fumagalli, Stefano, additional, Gareri, Pietro, additional, Malara, Alba, additional, Mossello, Enrico, additional, Monzani, Fabio, additional, Noale, Marianna, additional, Okoye, Chukwuma, additional, Onder, Graziano, additional, Trevisan, Caterina, additional, Volpato, Stefano, additional, and Zia, Gianluca, additional

Published
2023
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28. Multidimensional Oncological Frailty Scale (MOFS): A New Quick-To-Use Tool for Detecting Frailty and Stratifying Risk in Older Patients with Cancer—Development and Validation Pilot Study

Author

Franchi, Riccardo, primary, Okoye, Chukwuma, additional, Antognoli, Rachele, additional, Pompilii, Igino Maria, additional, Taverni, Irene, additional, Landi, Tommaso, additional, Ghilli, Matteo, additional, Roncella, Manuela, additional, Calsolaro, Valeria, additional, and Monzani, Fabio, additional

Published
2023
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29. Multidimensional Oncological Frailty Scale (MOFS) : A New Quick-To-Use Tool for Detecting Frailty and Stratifying Risk in Older Patients with Cancer-Development and Validation Pilot Study

Author

Franchi, Riccardo, Okoye, Chukwuma, Antognoli, Rachele, Pompilii, Igino Maria, Taverni, Irene, Landi, Tommaso, Ghilli, Matteo, Roncella, Manuela, Calsolaro, Valeria, Monzani, Fabio, Franchi, Riccardo, Okoye, Chukwuma, Antognoli, Rachele, Pompilii, Igino Maria, Taverni, Irene, Landi, Tommaso, Ghilli, Matteo, Roncella, Manuela, Calsolaro, Valeria, and Monzani, Fabio

Abstract

Background: Frailty detection with comprehensive geriatric assessment (CGA) is of pivotal importance in older patients with cancer to avoid over- or under-treatment and to detect those at increased risk for poor outcomes. Several tools have been developed to capture the complexity of frailty, but only a few were explicitly conceived for older adults with cancer. The study aimed at developing and validating a multidimensional, easy-to-use diagnostic tool for early-risk stratification in patients with cancer, called the Multidimensional Oncological Frailty Scale (MOFS). Methods: In this single-center prospective study, we consecutively enrolled 163 older women (age ≥ 75 years) with breast cancer, screened with a G8 score ≤ 14 during the outpatient preoperative evaluation at our breast centre, as the development cohort. Seventy patients with different types of cancer admitted to our OncoGeriatric Clinic served as the validation cohort. Using stepwise linear regression analysis, we evaluated the relationship between Multidimensional Prognostic Index (MPI) and CGA items, and, finally, realized a screening tool based on the combination of the significant variables. Results: The mean age of the study population was 80.4 ± 5.8 years, while the mean age of the validation cohort was 78.6 ± 6.6 years [42 women (60%)]. A composite model of the Clinical Frailty Scale, G8, and hand grip strength test showed a strong correlation with MPI (R= −0.712, p < 0.001). The MOFS accuracy in the prediction of mortality was optimal in both the development and the validation cohorts (AUC 0.82 and 0.87; p < 0.001 and 0.003, respectively). Conclusion: MOFS represents a new, accurate, quick-to-use frailty screening tool for stratifying the risk of mortality in geriatric cancer patients.

Published
2023
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30. Determinants of 1-Year Adverse Event Requiring Re-Hospitalization in COVID-19 Oldest Old Survivors

Author

Okoye, Chukwuma, Franchi, Riccardo, Calabrese, Alessia Maria, Morelli, Virginia, Peta, Umberto, Mazzarone, Tessa, Pompilii, Igino Maria, Coppini, Giulia, Rogani, Sara, Calsolaro, Valeria, Monzani, Fabio, Okoye, Chukwuma, Franchi, Riccardo, Calabrese, Alessia Maria, Morelli, Virginia, Peta, Umberto, Mazzarone, Tessa, Pompilii, Igino Maria, Coppini, Giulia, Rogani, Sara, Calsolaro, Valeria, and Monzani, Fabio

Abstract

The incidence of “Long COVID” syndrome appears to be increasing, particularly in the geriatric population. At present, there are few data regarding the relationship between long COVID and the risk of re-hospitalization in the oldest old survivors. Patients older than 80 years consecutively hospitalized for COVID-19 in our tertiary care hospital were enrolled and followed after discharge in a 12-month ambulatory program. A comprehensive geriatric assessment (CGA), including functional capabilities and physical and cognitive performances, was performed at 6-month follow-up. Frailty degree was assessed using a 30-item frailty index. The re-hospitalization rate was assessed at 12-month follow-up through a computerized archive and phone interviews. Out of 100 patients discharged after hospitalization for COVID-19 (mean [SD] age 85 [4.0] years), 24 reported serious adverse events requiring re-hospitalization within 12 months. The most frequent causes of re-hospitalization were acute heart failure (HF), pneumonia and bone fracture (15.3% each). By multivariate logistic analysis, after adjustment for potential confounders, history of chronic HF [aOR: 3.00 (CI 95%: 1.10–8.16), p = 0.031] or chronic renal failure [aOR: 3.83 (CI 95%: 1.09–13.43), p = 0.036], the burden of comorbidity [(CIRSc) aOR: 1.95 (CI 95%: 1.28–2.97), p = 0.002] and frailty [aOR: 7.77 (CI 95%: 2.13–28.27), p = 0.002] resulted as independent predictors of re-hospitalization. One-fourth of the oldest old patients previously hospitalized for COVID-19 suffered from adverse events requiring re-hospitalization, two-thirds of them within three months after discharge. Frailty, the burden of comorbidity, history of chronic HF or chronic renal failure, but not COVID-19 disease severity, independently predicted re-hospitalization.

Published
2023
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31. Frailty, psychological well-being, and social isolation in older adults with cognitive impairment during the SARS-CoV-2 pandemic: data from the GeroCovid initiative

Author

Terziotti, C, Ceolin, C, Devita, M, Raffaelli, C, Antenucci, S, Bazzano, S, Capasso, A, Castellino, M, Signore, S, Lubian, F, Maiotti, M, Monacelli, F, Mormile, M, Sgarito, C, Vella, F, Sergi, G, Gareri, P, Trevisan, C, Bellio, A, Fini, F, Malara, A, Mossello, E, Fumagalli, S, Volpato, S, Monzani, F, Bellelli, G, Zia, G, Incalzi, R, Coin, A, Terziotti, Camilla, Ceolin, Chiara, Devita, Maria, Raffaelli, Cecilia, Antenucci, Sara, Bazzano, Salvatore, Capasso, Andrea, Castellino, Manuela, Signore, Stefania Del, Lubian, Francesca, Maiotti, Mariangela, Monacelli, Fiammetta, Mormile, Maria Teresa, Sgarito, Claudia, Vella, Filomena, Sergi, Giuseppe, Gareri, Pietro, Trevisan, Caterina, Bellio, Andrea, Fini, Filippo, Malara, Alba, Mossello, Enrico, Fumagalli, Stefano, Volpato, Stefano, Monzani, Fabio, Bellelli, Giuseppe, Zia, Gianluca, Incalzi, Raffaele Antonelli, Coin, Alessandra, Terziotti, C, Ceolin, C, Devita, M, Raffaelli, C, Antenucci, S, Bazzano, S, Capasso, A, Castellino, M, Signore, S, Lubian, F, Maiotti, M, Monacelli, F, Mormile, M, Sgarito, C, Vella, F, Sergi, G, Gareri, P, Trevisan, C, Bellio, A, Fini, F, Malara, A, Mossello, E, Fumagalli, S, Volpato, S, Monzani, F, Bellelli, G, Zia, G, Incalzi, R, Coin, A, Terziotti, Camilla, Ceolin, Chiara, Devita, Maria, Raffaelli, Cecilia, Antenucci, Sara, Bazzano, Salvatore, Capasso, Andrea, Castellino, Manuela, Signore, Stefania Del, Lubian, Francesca, Maiotti, Mariangela, Monacelli, Fiammetta, Mormile, Maria Teresa, Sgarito, Claudia, Vella, Filomena, Sergi, Giuseppe, Gareri, Pietro, Trevisan, Caterina, Bellio, Andrea, Fini, Filippo, Malara, Alba, Mossello, Enrico, Fumagalli, Stefano, Volpato, Stefano, Monzani, Fabio, Bellelli, Giuseppe, Zia, Gianluca, Incalzi, Raffaele Antonelli, and Coin, Alessandra

Abstract

Background: The containment measures linked to the COVID-19 pandemic negatively affected the phyco-physical well-being of the population, especially older adults with neurocognitive disorders (NCDs). This study aims to evaluate whether the frailty of NCD patients was associated with different changes in multiple health domains, in particular in relation to loneliness and social isolation, pre- and post-lockdown. Materials and Methods: Patients were recruited from 10 Italian Centers for Cognitive Disorders and Dementia. Data were collected in the pre-pandemic period (T0), during the pandemic lockdown (T1), and 6–9 months post-lockdown (T2). The UCLA Loneliness Scale-3, Activities of Daily Living (ADL), Instrumental ADL (IADL), Mini-Mental State Examination, and Neuropsychiatric Inventory (NPI) were administered. Caregivers' burden was also tested. Patients were categorized as non-frail, pre-frail, and frail according to the Fatigue, Resistance, Ambulation, Illness, and Loss of Weight scale. Results: The sample included 165 subjects (61.9% women, mean age 79.5 ± 4.9 years). In the whole sample, the ADL, IADL, and NPI scores significantly declined between T0 and T2. There were no significative variations in functional and cognitive domains between the frail groups. During lockdown we recorded higher Depression Anxiety Stress Scales and Perceived Stress Scale scores in frail people. In multivariable logistic regression, frailty was associated with an increase in social isolation, and a loss of IADL. Conclusions: We observed a global deterioration in functional and neuro-psychiatric domains irrespective of the degree of frailty. Frailty was associated with the worsening of social isolation during lockdown. Frail patients and their caregivers seemed to experience more anxiety and stress disorders during SARS-CoV-2 pandemic.

Published
2023

32. The Free Triiodothyronine/Free Thyroxine Ratio Is Associated with Frailty in Older Adults: A Longitudinal Multisetting Study

Author

Okoye, C, Arosio, B, Carino, S, Putrino, L, Franchi, R, Rogani, S, Cesari, M, Mari, D, Vitale, G, Malara, A, Calsolaro, V, Monzani, F, Okoye, Chukwuma, Arosio, Beatrice, Carino, Silvia, Putrino, Luana, Franchi, Riccardo, Rogani, Sara, Cesari, Matteo, Mari, Daniela, Vitale, Giovanni, Malara, Alba, Calsolaro, Valeria, Monzani, Fabio, Okoye, C, Arosio, B, Carino, S, Putrino, L, Franchi, R, Rogani, S, Cesari, M, Mari, D, Vitale, G, Malara, A, Calsolaro, V, Monzani, F, Okoye, Chukwuma, Arosio, Beatrice, Carino, Silvia, Putrino, Luana, Franchi, Riccardo, Rogani, Sara, Cesari, Matteo, Mari, Daniela, Vitale, Giovanni, Malara, Alba, Calsolaro, Valeria, and Monzani, Fabio

Abstract

Background: Various models have been proposed to predict frailty, including those based on clinical criteria and phenotypes. However, a simple biomarker associated with frailty has been not yet identified. The aim of this study is to evaluate the relationship between free triiodothyronine (fT3)/free thyroxine (fT4) ratio value and the degree of frailty among three different cohorts of older individuals: (1) acutely ill hospitalized patients, (2) nursing-home (NH) residents, and (3) home-dwelling centenarians.Methods: We performed a secondary analysis of de-identified patient-level data from two prospective observational studies on acutely hospitalized older patients (Geriatric Acute Unit [GAU]), and home-dwelling centenarians (CENT), and a retrospective-prospective observational study on older NH residents. Demographic characteristics, along with a 30-items Frailty Index (FI) and serum thyrotropin, fT3 and fT4 measurements were obtained.Results: Six hundred fifteen individuals (aged 86.4 +/- 8.9 years; 55.1% females) were included in the study, including 298 (48.5%) GAU, 250 (40.6%) NH, and 67 (10.9%) CENT. A significant inverse relationship between fT3/fT4 ratio and FI values was observed (rho(s) = -0.17 [confidence interval; CI: -0.092 to 0.252], p < 0.001), and this was confirmed by logistic multivariate analysis (beta = -0.44, odds ratio [OR]: 0.64 [CI: 0.47-0.87], p < 0.001) (after adjustment for age, sex, and cohorts). Moreover, a progressively decreased mortality risk was associated with rising fT3/fT4 ratio (OR 0.60 [CI: 0.44-0.80] beta = -0.51, p < 0.001].Conclusions: The fT3/fT4 ratio value was inversely correlated with frailty degree and mortality risk in a large cohort of older individuals, including centenarians, regardless of their sex and clinical condition. fT3/fT4 ratio value could represent an easily measured independent biochemical marker of frailty degree in older people.

Published
2023

33. The Free Triiodothyronine/Free Thyroxine Ratio Is Associated with Frailty in Older Adults: A Longitudinal Multisetting Study

Author

Okoye, Chukwuma, primary, Arosio, Beatrice, additional, Carino, Silvia, additional, Putrino, Luana, additional, Franchi, Riccardo, additional, Rogani, Sara, additional, Cesari, Matteo, additional, Mari, Daniela, additional, Vitale, Giovanni, additional, Malara, Alba, additional, Calsolaro, Valeria, additional, and Monzani, Fabio, additional

Published
2023
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35. Utility of lung ultrasound in selecting older patients with hyperinflammatory phase in COVID-19 pneumonia. A monocentric, cross-sectional pilot study

Author

Franchi, Riccardo, primary, Okoye, Chukwuma, additional, Morelli, Virginia, additional, Guarino, Daniela, additional, Mazzarone, Tessa, additional, Coppini, Giulia, additional, Peta, Umberto, additional, Rogani, Sara, additional, Fabbri, Alessandra, additional, Polini, Antonio, additional, and Monzani, Fabio, additional

Published
2022
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36. Efficacy of COVID-19 control measures on post-vaccination outbreak in Italian Long Term Care Facilities: implications for policies

Author

Malara, Alba, Noale, Marianna, Trevisan, Caterina, Abbatecola, Angela Marie, Borselli, Gilda, Cafariello, Carmine, Gareri, Pietro, Fumagalli, Stefano, Mossello, Enrico, Volpato, Stefano, Monzani, Fabio, Coin, Alessandra, Okoye, Chukwuma, Bellelli, Giuseppe, Del Signore, Stefania, Zia, Gianluca, Antonelli Incalzi, Raffaele, Palmieri, Annapina, Fedele, Giorgio, Onder, Graziano, Malara, A, Noale, M, Trevisan, C, Abbatecola, A, Borselli, G, Cafariello, C, Gareri, P, Fumagalli, S, Mossello, E, Volpato, S, Monzani, F, Coin, A, Okoye, C, Bellelli, G, Del Signore, S, Zia, G, Antonelli Incalzi, R, Palmieri, A, Fedele, G, and Onder, G

Subjects
COVID-19 vaccination, pandemic fatigue, outbreak control measure, Public Health, Environmental and Occupational Health, SARS CoV-2 infection, Long Term Care Facilities (LTCFS)
Abstract

BackgroundNumerous individual and organizational factors can influence the spread of SARS-CoV-2 infection in Long Term Care Facilities (LTCFs). A range of outbreak control measures are still implemented in most facilities involving administrations, staff, residents and their families. This study aims to evaluate which measure could influence the transmission of SARS-CoV-2 infection among residents during the period March 2021-June 2022. MethodsWe enrolled 3,272 residents aged >= 60 years. The outbreak control measures adopted to prevent or manage the infection included entry regulations, contact-regulating procedures, and virological surveillance of residents and staff. The association between LTCFs' and participants' characteristics with new cases of COVID-19 infections was analyzed using multilevel logistic regression models. ResultsIn 33.8% of the facilities 261 cases of SARS-CoV-2 infection were reported. Among participant characteristics, gender and age were not associated with SARS-CoV-2 infection, while having received the vaccine booster dose was protective against infection [Odds Ratio (OR) = 0.34, 95% Confidence Interval (CI) 0.12-0.99, p = 0.048]. In addition, the implementation of protected areas for family visits was associated with a significant reduction of the probability of infections (OR = 0.18, 95% CI 0.03-0.98, p = 0.047). Overall, about 66% of the variability in the probability of SARS-CoV-2 infection during the observational period may be due to facility structure characteristics and 34% to the participant characteristics. ConclusionsThese data showed that vaccination booster doses and family visit restriction-control are still needed to make the LTCFs safer against SARS-CoV-2 infection.

Published
2023

37. Determinants of Cause-Specific Mortality and Loss of Independence in Older Patients following Hospitalization for COVID-19: The GeroCovid Outcomes Study

Author

Okoye, Chukwuma, primary, Calsolaro, Valeria, additional, Calabrese, Alessia Maria, additional, Zotti, Sonia, additional, Fedecostante, Massimiliano, additional, Volpato, Stefano, additional, Fumagalli, Stefano, additional, Cherubini, Antonio, additional, Antonelli Incalzi, Raffaele, additional, and Monzani, Fabio, additional

Published
2022
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42. Determinants of Cause-Specific Mortality and Loss of Independence in Older Patients following Hospitalization for COVID-19 : The GeroCovid Outcomes Study

Author

Okoye, Chukwuma, Calsolaro, Valeria, Calabrese, Alessia Maria, Zotti, Sonia, Fedecostante, Massimiliano, Volpato, Stefano, Fumagalli, Stefano, Cherubini, Antonio, Incalzi, Raffaele Antonelli, Monzani, Fabio, Okoye, Chukwuma, Calsolaro, Valeria, Calabrese, Alessia Maria, Zotti, Sonia, Fedecostante, Massimiliano, Volpato, Stefano, Fumagalli, Stefano, Cherubini, Antonio, Incalzi, Raffaele Antonelli, and Monzani, Fabio

Abstract

Hospitalization for acute SARS-CoV-2 infection confers an almost five-fold higher risk of post-discharge, all-cause mortality compared to controls from the general population. A negative impact on the functional autonomy of older patients, especially in cases of severe disease and prolonged hospitalization, has been recently described. However, little is known about the determinants of cause-specific mortality and loss of independence (LOI) in the activities of daily living (ADL) following COVID-19 hospitalization. Thus, the current prospective, multicenter study is aimed at identifying the determinants of post-discharge cause-specific mortality and the loss of autonomy in at least one ADL function. Older patients hospitalized for a SARS-CoV-2 infection were consecutively enrolled in an e-Registry from 1 March 2020, until 31 December 2020. After at least six months from discharge, patients were extensively re-evaluated according to a common protocol at the outpatient clinic of eight tertiary care Italian hospitals. Of 193 patients [109 (56.4%) men, mean age 79.9 ± 9.1 years], 43 (22.3%) died during follow-up. The most common causes of death were cardiovascular diseases (46.0%), respiratory failure (26.5%), and gastrointestinal and genitourinary diseases (8.8% each). Pre-morbid ADLs qualified as an independent mortality risk factor [adjusted HR 0.77 (95%CI: 0.63–0.95)]. Of 132 patients, 28 (21.2%) lost their independence in at least one ADL. The adjusted risk of LOI declined with a lower frailty degree [aOR 0.03 (95%CI: 0.01–0.32)]. In conclusion, at long-term follow-up after hospitalization for acute SARS-CoV-2 infection, more than 40% of older patients died or experienced a loss of functional independence compared to their pre-morbid condition. Given its high prevalence, the loss of functional independence after hospitalization for COVID-19 could be reasonably included among the features of the “Long COVID-19 syndrome” of older patients.

Published
2022
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43. Determinants of Cause-Specific Mortality and Loss of Independence in Older Patients following Hospitalization for COVID-19: The GeroCovid Outcomes Study

Author

Okoye, C, Calsolaro, V, Calabrese, A, Zotti, S, Fedecostante, M, Volpato, S, Fumagalli, S, Cherubini, A, Antonelli Incalzi, R, Monzani, F, Okoye, Chukwuma, Calsolaro, Valeria, Calabrese, Alessia Maria, Zotti, Sonia, Fedecostante, Massimiliano, Volpato, Stefano, Fumagalli, Stefano, Cherubini, Antonio, Antonelli Incalzi, Raffaele, Monzani, Fabio, Okoye, C, Calsolaro, V, Calabrese, A, Zotti, S, Fedecostante, M, Volpato, S, Fumagalli, S, Cherubini, A, Antonelli Incalzi, R, Monzani, F, Okoye, Chukwuma, Calsolaro, Valeria, Calabrese, Alessia Maria, Zotti, Sonia, Fedecostante, Massimiliano, Volpato, Stefano, Fumagalli, Stefano, Cherubini, Antonio, Antonelli Incalzi, Raffaele, and Monzani, Fabio

Abstract

Hospitalization for acute SARS-CoV-2 infection confers an almost five-fold higher risk of post-discharge, all-cause mortality compared to controls from the general population. A negative impact on the functional autonomy of older patients, especially in cases of severe disease and prolonged hospitalization, has been recently described. However, little is known about the determinants of cause-specific mortality and loss of independence (LOI) in the activities of daily living (ADL) following COVID-19 hospitalization. Thus, the current prospective, multicenter study is aimed at identifying the determinants of post-discharge cause-specific mortality and the loss of autonomy in at least one ADL function. Older patients hospitalized for a SARS-CoV-2 infection were consecutively enrolled in an e-Registry from 1 March 2020, until 31 December 2020. After at least six months from discharge, patients were extensively re-evaluated according to a common protocol at the outpatient clinic of eight tertiary care Italian hospitals. Of 193 patients [109 (56.4%) men, mean age 79.9 +/- 9.1 years], 43 (22.3%) died during follow-up. The most common causes of death were cardiovascular diseases (46.0%), respiratory failure (26.5%), and gastrointestinal and genitourinary diseases (8.8% each). Pre-morbid ADLs qualified as an independent mortality risk factor [adjusted HR 0.77 (95%CI: 0.63-0.95)]. Of 132 patients, 28 (21.2%) lost their independence in at least one ADL. The adjusted risk of LOI declined with a lower frailty degree [aOR 0.03 (95%CI: 0.01-0.32)]. In conclusion, at long-term follow-up after hospitalization for acute SARS-CoV-2 infection, more than 40% of older patients died or experienced a loss of functional independence compared to their pre-morbid condition. Given its high prevalence, the loss of functional independence after hospitalization for COVID-19 could be reasonably included among the features of the "Long COVID-19 syndrome" of older patients.

Published
2022

44. Covid-19 as a paradigmatic model of the heterogeneous disease presentation in older people: data from the GeroCovid Observational study

Author

Trevisan, C, Remelli, F, Fumagalli, S, Mossello, E, Okoye, C, Bellelli, G, Coin, A, Malara, A, Gareri, P, Monzani, F, Del Signore, S, Zia, G, Antonelli Incalzi, R, Volpato, S, Trevisan, Caterina, Remelli, Francesca, Fumagalli, Stefano, Mossello, Enrico, Okoye, Chukwuma, Bellelli, Giuseppe, Coin, Alessandra, Malara, Alba, Gareri, Pietro, Monzani, Fabio, Del Signore, Susanna, Zia, Gianluca, Antonelli Incalzi, Raffaele, Volpato, Stefano, Trevisan, C, Remelli, F, Fumagalli, S, Mossello, E, Okoye, C, Bellelli, G, Coin, A, Malara, A, Gareri, P, Monzani, F, Del Signore, S, Zia, G, Antonelli Incalzi, R, Volpato, S, Trevisan, Caterina, Remelli, Francesca, Fumagalli, Stefano, Mossello, Enrico, Okoye, Chukwuma, Bellelli, Giuseppe, Coin, Alessandra, Malara, Alba, Gareri, Pietro, Monzani, Fabio, Del Signore, Susanna, Zia, Gianluca, Antonelli Incalzi, Raffaele, and Volpato, Stefano

Abstract

COVID-19 may have a heterogeneous onset, especially in older age. However, whether and how COVID-19 signs and symptoms may present and aggregate together according to sociodemographic and health factors is unclear, as well as their prognostic value. This study included 981 COVID-19 inpatients who participated in the GeroCovid Observational study. Signs/symptoms at disease onset, sociodemographic, health, cognitive status, and mobility were systematically recorded. Clusters of signs/symptoms were identified through agglomerative hierarchical clustering. The associations of single signs/symptoms and symptom clusters with longer hospitalization (≥16 days) and in-hospital mortality were explored through logistic and Cox regressions. The signs/symptoms most reported in our sample (age 78.3 ± 9.39 years; 49.4% women) were fever (62.5%), cough (45.5%), and dyspnea (62.7%). Atypical symptoms were reported by up to one-third of patients, and delirium by 9.1%. Atypical symptoms were more frequent with advancing age and with lower pre-COVID-19 cognitive and mobility levels. Older men more likely reported respiratory symptoms than women. Dyspnea (hazard ratio [HR] = 1.47, 95% confidence interval [CI]: 1.02-2.12), tachypnea (HR = 1.53, 95% CI: 1.14-2.07), low oxygen saturation (HR = 1.95, 95% CI: 1.32-2.88) and delirium (HR = 1.60, 95% CI: 1.13-2.28) were associated with higher in-hospital mortality. Four symptom clusters were identified. Compared with the mild respiratory symptoms cluster, the severe clinical impairment cluster was associated with higher mortality (HR = 2.57, 95% CI: 1.58-4.18). The severe clinical impairment and aspecific symptoms clusters were associated with longer hospitalization (odds ratio [OR] = 2.38, 95% CI: 1.56-3.63, and OR = 1.75, 95% CI: 1.08-2.83, respectively). Multiple health aspects influence COVID-19 clinical presentation. A symptom clusters approach may help predict adverse health outcomes in older patients. In addition to respiratory symptoms

Published
2022

45. COVID-19 Signs and Symptom Clusters in Long-Term Care Facility Residents: Data from the GeroCovid Observational Study

Author

Malara, A, Noale, M, Abbatecola, A, Borselli, G, Cafariello, C, Fumagalli, S, Gareri, P, Mossello, E, Trevisan, C, Volpato, S, Monzani, F, Coin, A, Bellelli, G, Okoye, C, Del Signore, S, Zia, G, Incalzi, R, Malara, Alba, Noale, Marianna, Abbatecola, Angela Marie, Borselli, Gilda, Cafariello, Carmine, Fumagalli, Stefano, Gareri, Pietro, Mossello, Enrico, Trevisan, Caterina, Volpato, Stefano, Monzani, Fabio, Coin, Alessandra, Bellelli, Giuseppe, Okoye, Chukwuma, Del Signore, Stefania, Zia, Gianluca, Incalzi, Raffaele Antonelli, Malara, A, Noale, M, Abbatecola, A, Borselli, G, Cafariello, C, Fumagalli, S, Gareri, P, Mossello, E, Trevisan, C, Volpato, S, Monzani, F, Coin, A, Bellelli, G, Okoye, C, Del Signore, S, Zia, G, Incalzi, R, Malara, Alba, Noale, Marianna, Abbatecola, Angela Marie, Borselli, Gilda, Cafariello, Carmine, Fumagalli, Stefano, Gareri, Pietro, Mossello, Enrico, Trevisan, Caterina, Volpato, Stefano, Monzani, Fabio, Coin, Alessandra, Bellelli, Giuseppe, Okoye, Chukwuma, Del Signore, Stefania, Zia, Gianluca, and Incalzi, Raffaele Antonelli

Abstract

Background: Long-term care facility (LTCF) residents often present asymptomatic or paucisymptomatic features of SARS-CoV-2 infection. We aimed at investigating signs/symptoms, including their clustering on SARS-CoV-2 infection and mortality rates associated with SARS-CoV-2 infection in LTCF residents. Methods: This is a cohort study of 586 aged ≥ 60 year-old residents at risk of or affected with COVID-19 enrolled in the GeroCovid LTCF network. COVID-19 signs/symptom clusters were identified using cluster analysis. Cluster analyses associated with SARS-CoV-2 infection and mortality were evaluated using logistic regression and Cox proportional hazard models. Results: Cluster 1 symptoms (delirium, fever, low-grade fever, diarrhea, anorexia, cough, increased respiratory rate, sudden deterioration in health conditions, dyspnea, oxygen saturation, and weakness) affected 39.6% of residents and were associated with PCR swab positivity (OR = 7.21, 95%CI 4.78–10.80; p < 0.001). Cluster 1 symptoms were present in deceased COVID-19 residents. Cluster 2 (increased blood pressure, sphincter incontinence) and cluster 3 (new-onset cognitive impairment) affected 20% and 19.8% of residents, respectively. Cluster 3 symptoms were associated with increased mortality (HR = 5.41, 95%CI 1.56–18.8; p = 0.008), while those of Cluster 2 were not associated with mortality (HR = 0.82, 95%CI 0.26–2.56; p = 730). Conclusions: Our study highlights that delirium, fever, and low-grade fever, alone or in clusters should be considered in identifying and predicting the prognosis of SARS-CoV-2 infection in older LTCF patients.

Published
2022

46. Computed tomography findings and prognosis in older COVID-19 patients

Author

Okoye, C, Finamore, P, Bellelli, G, Coin, A, Del Signore, S, Fumagalli, S, Gareri, P, Malara, A, Mossello, E, Trevisan, C, Volpato, S, Zia, G, Monzani, F, Incalzi, R, Okoye, Chukwuma, Finamore, Panaiotis, Bellelli, Giuseppe, Coin, Alessandra, Del Signore, Susanna, Fumagalli, Stefano, Gareri, Pietro, Malara, Alba, Mossello, Enrico, Trevisan, Caterina, Volpato, Stefano, Zia, Gianluca, Monzani, Fabio, Incalzi, Raffaele Antonelli, Okoye, C, Finamore, P, Bellelli, G, Coin, A, Del Signore, S, Fumagalli, S, Gareri, P, Malara, A, Mossello, E, Trevisan, C, Volpato, S, Zia, G, Monzani, F, Incalzi, R, Okoye, Chukwuma, Finamore, Panaiotis, Bellelli, Giuseppe, Coin, Alessandra, Del Signore, Susanna, Fumagalli, Stefano, Gareri, Pietro, Malara, Alba, Mossello, Enrico, Trevisan, Caterina, Volpato, Stefano, Zia, Gianluca, Monzani, Fabio, and Incalzi, Raffaele Antonelli

Abstract

Background: In older and multimorbid patients, chronic conditions may affect the prognostic validity of computed tomography (CT) findings in COVID-19. This study aims at assessing to which extent CT findings have prognostic implications in COVID-19 older patients. Methods: Hospitalized COVID-19 patients aged 60 years or more enrolled in the multicenter, observational and longitudinal GeroCovid study who underwent chest CT were included. Patients were stratified by tertiles of age and pneumonia severity to compare CT findings. Hierarchical clustering based on CT findings was performed to identify CT-related classificatory constructs, if any. The hazard ratio (HR) of mortality was calculated for individual CT findings and for clusters, after adjusting for potential confounders. Results: 380 hospitalized COVID-19 patients, with a mean age of 78 (SD:9) years, underwent chest CT scan. Ground glass opacity (GGO), consolidation, and pleural effusion were the three most common CT findings, with GGO prevalence decreasing from younger to older patients and pleural effusion increasing. More severe the pneumonia more prevalent were GGO, consolidation and pleural effusion. HR of mortality was 1.94 (95%CI 1.24–3.06) for pleural effusion and 13 (95%CI 6.41–27) for cluster with a low prevalence of GGO and a high prevalence of pleural effusion (“LH”), respectively. Out of the three CT based clusters, “LH” was the only independent predictor in the multivariable model. Conclusions: Pleural effusion qualifies as a distinctive prognostic marker in older COVID-19 patients. Research is needed to verify whether pleural effusion reflects COVID-19 severity or a coexisting chronic condition making the patient at special risk of death. Trial registration: ClinicalTrials.gov: NCT04379440

Published
2022

47. Clinical Features of SARS-CoV-2 Infection in Italian Long-Term Care Facilities: GeroCovid LTCFs Observational Study

Author

Malara, A, Noale, M, Abbatecola, A, Borselli, G, Cafariello, C, Fumagalli, S, Gareri, P, Mossello, E, Trevisan, C, Volpato, S, Monzani, F, Coin, A, Bellelli, G, Okoye, C, Del Signore, S, Zia, G, Antonelli Incalzi, R, Malara, Alba, Noale, Marianna, Abbatecola, Angela Marie, Borselli, Gilda, Cafariello, Carmine, Fumagalli, Stefano, Gareri, Pietro, Mossello, Enrico, Trevisan, Caterina, Volpato, Stefano, Monzani, Fabio, Coin, Alessandra, Bellelli, Giuseppe, Okoye, Chukwuma, Del Signore, Susanna, Zia, Gianluca, Antonelli Incalzi, Raffaele, Malara, A, Noale, M, Abbatecola, A, Borselli, G, Cafariello, C, Fumagalli, S, Gareri, P, Mossello, E, Trevisan, C, Volpato, S, Monzani, F, Coin, A, Bellelli, G, Okoye, C, Del Signore, S, Zia, G, Antonelli Incalzi, R, Malara, Alba, Noale, Marianna, Abbatecola, Angela Marie, Borselli, Gilda, Cafariello, Carmine, Fumagalli, Stefano, Gareri, Pietro, Mossello, Enrico, Trevisan, Caterina, Volpato, Stefano, Monzani, Fabio, Coin, Alessandra, Bellelli, Giuseppe, Okoye, Chukwuma, Del Signore, Susanna, Zia, Gianluca, and Antonelli Incalzi, Raffaele

Published
2022

48. COVID-19 and atrial fibrillation in older patients. Does oral anticoagulant therapy provide a survival benefit? An insight from the GeroCovid Registry

Author

Fumagalli, S, Trevisan, C, Del Signore, S, Pelagalli, G, Volpato, S, Gareri, P, Mossello, E, Malara, A, Monzani, F, Coin, A, Bellelli, G, Zia, G, Antonelli Incalzi, R, Fumagalli, Stefano, Trevisan, Caterina, Del Signore, Susanna, Pelagalli, Giulia, Volpato, Stefano, Gareri, Pietro, Mossello, Enrico, Malara, Alba, Monzani, Fabio, Coin, Alessandra, Bellelli, Giuseppe, Zia, Gianluca, Antonelli Incalzi, Raffaele, Fumagalli, S, Trevisan, C, Del Signore, S, Pelagalli, G, Volpato, S, Gareri, P, Mossello, E, Malara, A, Monzani, F, Coin, A, Bellelli, G, Zia, G, Antonelli Incalzi, R, Fumagalli, Stefano, Trevisan, Caterina, Del Signore, Susanna, Pelagalli, Giulia, Volpato, Stefano, Gareri, Pietro, Mossello, Enrico, Malara, Alba, Monzani, Fabio, Coin, Alessandra, Bellelli, Giuseppe, Zia, Gianluca, and Antonelli Incalzi, Raffaele

Abstract

Introduction. Atrial fibrillation (AF), the most frequent arrhythmia of older patients, associates with serious thrombo-embolic complications and high mortality. COVID-19 severely affects aged subjects, determining an important prothrombotic status. Aim of this study was to evaluate mortality-related factors in older AF patients with COVID-19. Methods. Between March and June 2020, we enrolled >=60 years in-hospital COVID-19 patients (N=806) in GeroCovid, a multicenter observational study promoted by the Italian Society of Gerontology and Geriatric Medicine. Results. The prevalence of AF was 21.8%. In-hospital mortality was higher in the AF group (36.9 vs. 27.5%, p=0.015). At admission, 51.7%, 10.2% and 38.1% of AF cases were taking, respectively, oral anticoagulants (OACs), antiplatelet agents and no antithrombotic therapy. During hospitalization, 51% patients switched to low-molecular weight heparins. AF patients who survived were younger (81±8 vs. 84±7 years; p=0.002) and had a lower CHA2DS2-VASc score (3.9±1.6 vs. 4.4±1.3; p=0.02) than those who died. OACs use before (63.1% vs. 32.3%; p<0.001) and during hospitalization (34.0% vs. 12.7%; p=0.002) was higher among survivors. At multivariable analysis, lower age, higher self-sufficiency, less severe initial COVID-19 presentation, and the use of Vitamin K antagonists (OR=0.16, 95%CI: 0.03-0.84) or DOACs (OR=0.22, 95%CI: 0.08-0.56) at admission, or the persistence of OAC during hospitalization (OR=0.05, 95%CI: 0.01-0.24), were associated with a lower chance of in-hospital death. Conclusions. AF is a prevalent and severe condition in older COVID-19 patients. Advanced age, dependency and relevant clinical manifestations of disease characterized a worse prognosis. Pre-admission and in-hospital anticoagulant therapy were positively associated with survival.

Published
2022

49. Covid-19 as a paradigmatic model of the heterogeneous disease presentation in older people: data from the GeroCovid Observational study

Author

Trevisan, Caterina, primary, Remelli, Francesca, additional, Fumagalli, Stefano, additional, Mossello, Enrico, additional, Okoye, Chukwuma, additional, Bellelli, Giuseppe, additional, Coin, Alessandra, additional, Malara, Alba, additional, Gareri, Pietro, additional, Monzani, Fabio, additional, Del Signore, Susanna, additional, Zia, Gianluca, additional, Antonelli Incalzi, Raffaele, additional, and Volpato, Stefano, additional

Published
2022
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50. Monitoring COVID-19 vaccine use in Italian long term care centers: The GeroCovid VAX study

Author

Abbatecola, Angela Marie, primary, Incalzi, Raffaele Antonelli, additional, Malara, Alba, additional, Palmieri, Annapina, additional, Di Lonardo, Anna, additional, Fedele, Giorgio, additional, Stefanelli, Paola, additional, Borselli, Gilda, additional, Russo, Marcello, additional, Noale, Marianna, additional, Fumagalli, Stefano, additional, Gareri, Pietro, additional, Mossello, Enrico, additional, Trevisan, Caterina, additional, Volpato, Stefano, additional, Monzani, Fabio, additional, Coin, Alessandra, additional, Bellelli, Giuseppe, additional, Okoye, Chukwuma, additional, Del Signore, Susanna, additional, Zia, Gianluca, additional, Bottoni, Elisa, additional, Cafariello, Carmine, additional, and Onder, Graziano, additional

Published
2022
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