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1. Automatic Interpretation of F-Fluorocholine PET/CT Findings in Patients with Primary Hyperparathyroidism: A Novel Dataset with Benchmarks

Author

Sharma, Natasha, Balogova, Sona, Noskovicova, Lucia, Montravers, Françoise, Talbot, Jean-Noel, Trentin, Edmondo, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Suen, Ching Yee, editor, Krzyzak, Adam, editor, Ravanelli, Mirco, editor, Trentin, Edmondo, editor, Subakan, Cem, editor, and Nobile, Nicola, editor

Published
2024
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2. Activity of Lutetium-177 Prostate-specific Membrane Antigen and Determinants of Outcomes in Patients with Metastatic Castration-resistant Prostate Cancer Previously Treated with Cabazitaxel: The PACAP Study

Author

Flippot, Ronan, Telli, Tugce, Velev, Maud, Fléchon, Aude, De Vries-Brilland, Manon, Turpin, Léa, Bergman, Andries, Turco, Fabio, Mahammedi, Hakim, Fendler, Wolfgang P., Giraudet, Anne-Laure, Josset, Quentin, Montravers, Françoise, Vogel, Wouter, Gillessen, Silke, Berardi Vilei, Simona, Herrmann, Ken, Kryza, David, Paone, Gaetano, Hadaschik, Boris, Merlin, Charles, Dufour, Pierre-Alban, Bernard-Tessier, Alice, Naoun, Natacha, Patrikidou, Anna, Garcia, Camilo, Foulon, Stéphanie, Pagès, Arnaud, and Fizazi, Karim

Published
2024
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4. Congenital hyperinsulinism: current trends in diagnosis and therapy

Author

Bellanné-Chantelot Christine, Aigrain Yves, Robert Jean-Jacques, Fournet Jean-Christophe, Brunelle Francis, Valayannopoulos Vassili, Montravers Françoise, Brassier Anaïs, Saint-Martin Cécile, Verkarre Virginie, Arnoux Jean-Baptiste, and de Lonlay Pascale

Subjects
Congenital hyperinsulinism (HI), 18F-fluoro-L-DOPA positon emission tomography, Medicine
Abstract

Abstract Congenital hyperinsulinism (HI) is an inappropriate insulin secretion by the pancreatic β-cells secondary to various genetic disorders. The incidence is estimated at 1/50, 000 live births, but it may be as high as 1/2, 500 in countries with substantial consanguinity. Recurrent episodes of hyperinsulinemic hypoglycemia may expose to high risk of brain damage. Hypoglycemias are diagnosed because of seizures, a faint, or any other neurological symptom, in the neonatal period or later, usually within the first two years of life. After the neonatal period, the patient can present the typical clinical features of a hypoglycemia: pallor, sweat and tachycardia. HI is a heterogeneous disorder with two main clinically indistinguishable histopathological lesions: diffuse and focal. Atypical lesions are under characterization. Recessive ABCC8 mutations (encoding SUR1, subunit of a potassium channel) and, more rarely, recessive KCNJ11 (encoding Kir6.2, subunit of the same potassium channel) mutations, are responsible for most severe diazoxide-unresponsive HI. Focal HI, also diazoxide-unresponsive, is due to the combination of a paternally-inherited ABCC8 or KCNJ11 mutation and a paternal isodisomy of the 11p15 region, which is specific to the islets cells within the focal lesion. Genetics and 18F-fluoro-L-DOPA positron emission tomography (PET) help to diagnose diffuse or focal forms of HI. Hypoglycemias must be rapidly and intensively treated to prevent severe and irreversible brain damage. This includes a glucose load and/or a glucagon injection, at the time of hypoglycemia, to correct it. Then a treatment to prevent the recurrence of hypoglycemia must be set, which may include frequent and glucose-enriched feeding, diazoxide and octreotide. When medical and dietary therapies are ineffective, or when a focal HI is suspected, surgical treatment is required. Focal HI may be definitively cured when the partial pancreatectomy removes the whole lesion. By contrast, the long-term outcome of diffuse HI after subtotal pancreatectomy is characterized by a high risk of diabetes, but the time of its onset is hardly predictable.

Published
2011
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7. Diagnostic Applications of Nuclear Medicine: Pediatric Cancers

Author

Pfluger, Thomas, Ciarmiello, Andrea, Giovacchini, Giampiero, Montravers, Françoise, Le Pointe, Hubert Ducou, Landman-Parker, Judith, Meniconi, Martina, Franzius, Christiane, Volterrani, Duccio, editor, Erba, Paola A., editor, Strauss, H. William, editor, Mariani, Giuliano, editor, and Larson, Steven M., editor

Published
2022
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10. Comparison of Normocalcemic vs Hypercalcemic Primary Hyperparathyroidism in a Hypercalciuric Renal Stone Population.

Author

Halimi, Caroline, Bor, Clemence, Chieze, Remi, Saint-Jacques, Camille, Périé, Sophie, Wagner, Isabelle, Talbot, Jean-Noel, Montravers, Françoise, Letavernier, Emmanuel, Buob, David, Daudon, Michel, Frochot, Vincent, and Haymann, Jean-Philippe

Subjects
DIETARY calcium, PARATHYROID glands, BONE remodeling, DYNAMIC testing, HYPERPARATHYROIDISM, KIDNEY stones
Abstract

Context Primary hyperparathyroidism (PHPT) is commonly diagnosed in the setting of hypercalcemia, whereas normocalcemic primary hyperparathyroidism (NHPT) may be misdiagnosed. Objective Our objective was to compare patients with hypercalcemic hyperparathyroidism (HPHPT) vs patients with NHPT hypercalciuric renal stones. Methods We took advantage of a routine calcium load test performed in patients with hypercalciuric renal stones to assess retrospectively among patients with PHPT the prevalence and characteristics of NHPT and HPHPT under a calcium-restricted diet Results Among 1671 patients with hypercalciuria, 91 patients had a final diagnosis of PHPT (postload ionized calcium [iCa] > 1.31 mmol/L and parathyroid hormone [PTH] > 30 pg/mL). Prevalence of NHPT is 40% of all PHPT; however, according to total serum calcium, 4/35 NHPT and 7/56 HPHPT cases would have been misclassified in the other group. Eighteen of 35 NHPT and 40/56 HPHPT cases underwent parathyroidectomy. No significant characteristics relating to parathyroid weight, stone composition, or bone remodeling biomarkers were detected between groups. Although iCa is higher in HPHPT in the fasting state and after calcium load, we found no difference for calcium diet, 24-hour calciuria, or calcitriol. Renal calcium excretion postload increased by 303% in NHPT but only 176% in HPHPT (P =.01) likely explained by a lesser PTH decrease (P =.02). However, a strong negative association (P <.0001) detected between pooled preload and postload iCa and PTH only in the NHPT group suggests a persistent efficient PTH-CaSR control within the parathyroid glands in this group. Conclusion Our data show the relevance of dynamic tests to unmask NHPT in patients with hypercalciuric renal stones. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Response-adapted omission of radiotherapy and comparison of consolidation chemotherapy in children and adolescents with intermediate-stage and advanced-stage classical Hodgkin lymphoma (EuroNet-PHL-C1): a titration study with an open-label, embedded, multinational, non-inferiority, randomised controlled trial

Author

Mauz-Körholz, Christine, Landman-Parker, Judith, Balwierz, Walentyna, Ammann, Roland A, Anderson, Richard A, Attarbaschi, Andische, Bartelt, Jörg M, Beishuizen, Auke, Boudjemaa, Sabah, Cepelova, Michaela, Claviez, Alexander, Daw, Stephen, Dieckmann, Karin, Fernández-Teijeiro, Ana, Fosså, Alexander, Gattenlöhner, Stefan, Georgi, Thomas, Hjalgrim, Lisa L, Hraskova, Andrea, Karlén, Jonas, Kluge, Regine, Kurch, Lars, Leblanc, Thiery, Mann, Georg, Montravers, Francoise, Pears, Jean, Pelz, Tanja, Rajić, Vladan, Ramsay, Alan D, Stoevesandt, Dietrich, Uyttebroeck, Anne, Vordermark, Dirk, Körholz, Dieter, Hasenclever, Dirk, and Wallace, William Hamish

Published
2022
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18. Diagnostic Applications of Nuclear Medicine: Pediatric Cancers

Author

Pfluger, Thomas, Ciarmiello, Andrea, Giovacchini, Giampiero, Montravers, Françoise, Le Pointe, Hubert Ducou, Landman-Parker, Judith, Meniconi, Martina, Franzius, Christiane, Strauss, H. William, editor, Mariani, Giuliano, editor, Volterrani, Duccio, editor, and Larson, Steven M., editor

Published
2017
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19. 18F-fluorocholine PET/CT detects parathyroid gland hyperplasia as well as adenoma: 401 PET/CTs in one center

Author

TALBOT, Jean-Noël, primary, PÉRIÉ, Sophie, additional, TASSART, Marc, additional, DELBOT, Thierry, additional, AVELINE, Cyrielle, additional, ZHANG-YIN, Jules, additional, KERROU, Khaldoun, additional, GAUJOUX, Sébastien, additional, WAGNER, Isabelle, additional, BENNIS, Malika, additional, MÉNÉGAUX, Fabrice, additional, BRETON, Sarah, additional, COCHAND-PRIOLLET, Beatrix, additional, CHRISTIN-MAITRE, Sophie, additional, GROUSSIN, Lionel, additional, HAYMANN, Jean-Philippe, additional, BAUJAT, Bertrand, additional, BALOGOVA, Sona, additional, and MONTRAVERS, Françoise, additional

Published
2023
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26. Activity of lutetium-177 PSMA (Lu-PSMA) and determinants of outcomes in patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with cabazitaxel: The PACAP study.

Author

Flippot, Ronan, primary, Telli, Tugce, additional, Velev, Maud, additional, Flechon, Aude, additional, Turpin, Lea, additional, Bergman, Andre M., additional, Turco, Fabio, additional, Fendler, Wolfgang Peter, additional, Giraudet, Anne Laure, additional, Montravers, Françoise, additional, Vogel, Wouter V., additional, Gillessen, Silke, additional, Berardi, Simona, additional, Herrmann, Ken, additional, Kryza, David, additional, Paone, Gaetano, additional, Garcia, Camilo, additional, Foulon, Stéphanie, additional, Pages, Arnaud, additional, and Fizazi, Karim, additional

Published
2023
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27. Fully automated radiolabeling of [68Ga]Ga-EMP100 targeting c-MET for PET-CT clinical imaging.

Author

Rusu, Timofei, Delion, Matthieu, Pirot, Charlotte, Blin, Amaury, Rodenas, Anita, Talbot, Jean-Noël, Veran, Nicolas, Portal, Christophe, Montravers, Françoise, Cadranel, Jacques, and Prignon, Aurélie

Subjects
POSITRON emission tomography computed tomography, DIAGNOSTIC imaging, RADIOLABELING, RADIOCHEMICAL purification, CURRENT good manufacturing practices, CHELATING agents
Abstract

Background: c-MET is a transmembrane receptor involved in many biological processes and contributes to cell proliferation and migration during cancer invasion process. Its expression is measured by immunehistochemistry on tissue biopsy in clinic, although this technique has its limitations. PET-CT could allow in vivo mapping of lesions expressing c-MET, providing whole-body detection. A number of radiopharmaceuticals are under development for this purpose but are not yet in routine clinical use. EMP100 is a cyclic oligopeptide bound to a DOTA chelator, with nanomolar affinity for c-MET. The aim of this project was to develop an automated method for radiolabelling the radiopharmaceutical [68Ga]Ga-EMP100. Results: The main results showed an optimal pH range between 3.25 and 3.75 for the complexation reaction and a stabilisation of the temperature at 90 °C, resulting in an almost complete incorporation of gallium-68 after 10 min of heating. In these experiments, 90 µg of EMP-100 peptide were initially used and then lower amounts (30, 50, 75 µg) were explored to determine the minimum required for sufficient synthesis yield. Radiolysis impurities were identified by radio-HPLC and ascorbic acid and ethanol were used to improve the purity of the compound. Three batches of [68Ga]Ga-EMP100 were then prepared according to the optimised parameters and all met the established specifications. Finally, the stability of [68Ga]Ga-EMP100 was assessed at room temperature over 3 h with satisfactory results in terms of appearance, pH, radiochemical purity and sterility. Conclusions: For the automated synthesis of [68Ga]Ga-EMP100, the parameters of pH, temperature, precursor peptide content and the use of adjuvants for impurity management were efficiently optimised, resulting in the production of three compliant and stable batches according to the principles of good manufacturing practice. [68Ga]Ga-EMP100 was successfully synthesised and is now available for clinical development in PET-CT imaging. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Does 18F-FDG PET/CT add value to conventional imaging in clinical assessment of chronic disseminated candidiasis?

Author

Rammaert, Blandine, primary, Maunoury, Christophe, additional, Rabeony, Tioka, additional, Correas, Jean-Michel, additional, Elie, Caroline, additional, Alfandari, Serge, additional, Berger, Pierre, additional, Rubio, Marie-Thérèse, additional, Braun, Thorsten, additional, Bakouboula, Prissile, additional, Candon, Sophie, additional, Montravers, Françoise, additional, and Lortholary, Olivier, additional

Published
2022
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30. Pediatric Cancers

Author

Pfluger, Thomas, Giovacchini, Giampiero, Ciarmiello, Andrea, Montravers, Françoise, Le Pointe, Hubert Ducou, Landman-Parker, Judith, Franzius, Christiane, Strauss, H. William, editor, Mariani, Giuliano, editor, Volterrani, Duccio, editor, and Larson, Steven M., editor

Published
2013
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31. 18F-fluorocholine PET/CT detects parathyroid gland hyperplasia as well as adenoma: 401 PET/CTs in one center.

Author

TALBOT, Jean-Noël, PÉRIÉ, Sophie, TASSART, Marc, DELBOT, Thierry, AVELINE, Cyrielle, ZHANG-YIN, Jules, KERROU, Khaldoun, GAUJOUX, Sébastien, WAGNER, Isabelle, BENNIS, Malika, MÉNÉGAUX, Fabrice, BRETON, Sarah, COCHAND-PRIOLLET, Beatrix, CHRISTIN-MAITRE, Sophie, GROUSSIN, Lionel, HAYMANN, Jean-Philippe, BAUJAT, Bertrand, BALOGOVA, Sona, and MONTRAVERS, Françoise

Published
2023
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33. OS-077 Added value of a combination of positron emission tomography with 18F-FDG and 18 F-Fluorocholine for staging optimization and treatment modification in patients with hepatocellular carcinoma: the prospective multicentric PET HCC01 study

Author

Nault, Jean Charles, Boubaya, Marouane, Wartski, Myriam, Dohan, Anthony, Pol, Stanislas, Pop, Gabriel, Soussan, Michael, Seror, Olivier, Costentin, Charlotte, Roux, Julie, Sengel, Christian, Lequoy, Marie, Montravers, Francoise, Menu, Yves, Pageaux, Georges-Philippe, Goulart, Denis Mariano, Guiu, Boris, Luciani, Alain, Burgio, Marco Dioguardi, Wagner, Mathilde, Maksud, Philippe, Mulé, Sébastien, Allaire, Manon, Sidali, Sabrina, Coilly, Audrey, Besson, Florent, Lewin, Maite, Regnault, Hélène, Hollande, Clemence, Amaddeo, Giuliana, Ronot, Maxime, Ganne-Carrié, Nathalie, Lévy, Vincent, Rachida, Lebtahi, Chalaye, Julia, and Bouattour, Mohamed

Published
2024
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36. First Extensive Analysis of 18F-Labeled Fluorodeoxyglucose Positron Emission Tomography–Computed Tomography in a Large Cohort of Patients With HIV-Associated Hodgkin Lymphoma: Baseline Total Metabolic Tumor Volume Affects Prognosis

Author

Louarn, Nicolas, primary, Galicier, Lionel, additional, Bertinchamp, Rémi, additional, Lussato, David, additional, Montravers, Françoise, additional, Oksenhendler, Éric, additional, Merlet, Pascal, additional, Gérard, Laurence, additional, and Vercellino, Laetitia, additional

Published
2022
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38. Multiple endocrine neoplasia type 1 or 4: detection of hyperfunctioning parathyroid glands with 18F-fluorocholine PET/CT, illustrative cases and pitfalls

Author

TALBOT, Jean-Noël, primary, ZHANG-YIN, Jules, additional, KERROU, Khadoun, additional, AVELINE, Cyrielle, additional, VAGNE, Benedicte, additional, BÉLISSANT, Ophélie, additional, TASSART, Marc, additional, PÉRIÉ, Sophie, additional, BOUCHARD, Phillipe, additional, MAITRE, Sophie C., additional, MÉNÉGAUX, Fabrice, additional, GROUSSIN, Lionel, additional, GAUJOUX, Sébastien, additional, BALOGOVA, Sona, additional, and MONTRAVERS, Françoise, additional

Published
2022
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39. Over‐expression of IgG2 in patients resembling IgG4‐related disease with normal IgG4

Author

Lecuit, Mathilde, primary, Aucouturier, Pierre, additional, Abbas, Aicha, additional, Cadranel, Jacques, additional, Silvain, Christine, additional, Berthelot, Jean‐Marie, additional, Fauchais, Anne‐Laure, additional, Loubet, Paul, additional, Bachmeyer, Claude, additional, Montravers, Françoise, additional, Dossier, Antoine, additional, Nunes, Hilario, additional, Cervera, Pascale, additional, and Coppo, Paul, additional

Published
2021
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40. Feasibility, Safety and Impact of (18F)-FDG PET/CT in patients with pregnancy-associated cancer: experience of the French CALG (Cancer Associé à La Grossesse) network

Author

Despierres, Marie, primary, Boudy, Anne-Sophie, additional, Selleret, Lise, additional, Gligorov, Joseph, additional, Richard, Sandrine, additional, Thomassin, Isabelle, additional, Dabi, Yohann, additional, Zilberman, Sonia, additional, Touboul, Cyril, additional, Montravers, Françoise, additional, Khaldoun, Kerrou, additional, and Darai, Emile, additional

Published
2021
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41. [18F]FDG Positron Emission Tomography for Initial Staging and Healing Assessment at the End of Therapy in Lymph Nodes and Bone Tuberculosis

Author

Sarda-Mantel, Laure, primary, Kaoutar, Jidar, additional, Alfaiate, Toni, additional, Lopes, Amanda, additional, Paycha, Frédéric, additional, Benali, Khadija, additional, Mikail, Nidaa, additional, Soussan, Michael, additional, Lemarignier, Charles, additional, Méchaï, Frédéric, additional, Nagat, Sophie Le, additional, Montravers, Françoise, additional, Deradji, Ouda, additional, Durand, Emmanuel, additional, Goulenok, Tiphaine, additional, Ponscarme, Diane, additional, Yéni, Patrick, additional, Laouénan, Cédric, additional, and Rioux, Christophe, additional

Published
2021
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46. Tomographie par émission de positons et cancers digestifs

Author

Talbot, Jean-Noël, Montravers, Françoise, Gutman, Fabrice, Kerrou, Khaldoun, Huchet, Virginie, Grahek, Dany, Andre, Thierry, Houry, Sydney, Touboul, Emmanuel, Rosmorduc, Olivier, Poupon, Raoul, Ruszniewski, Philippe, Rougier, Philippe, and Grange, Jean-Didier

Published
2008
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