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Se realizó estudio descriptivo, comparativo de 74 casos de pacientes femeninas con diagnóstico histopatológico de adenocarcinoma de mama. A los pacientes se les practicó exceresis ganglionar, procesándose inicialmente con técnicas histoquímicas convencionales y posteriormente con técnicas inmunohistoquimicas utilizando el inmunomarcador HER-2/neu. Los resultados evidenciaron que el tipo histológico más frecuentemente diagnosticado fue el adenocarcinoma ductal infiltrante sin otra especificación (ADC Ductal SOE), en 65 casos (87,83 %), seguidos del ADC Ductal+ Comedocarcinoma, en ocho casos (10,81 %) y ADC Ductal + carcinoma medular en un caso (1,35%). Siendo el grupo etario más afectado el de las mujeres post menopáusicas de 50 años o más con un total de 34 casos (45,94%). Los ganglios linfáticos se encontraron afectados en 13 de las pacientes (17,56%), seis de las cuales presentaban un grado histológico II (46,15%) y siete un grado histológico III (53,85%).Así mismo, el comportamiento del inmunomarcador se manifestó positivamente en un 21,26% y negativo en un 78,38% con p≤ 0,05.Se concluye que los carcinomas de alta malignidad y estadios avanzados reprimen la expresión del HER-2/neu en un alto porcentaje la presencia de positividad para el mismo empobrece el pronosticó. De este modo el conocimiento del tipo y grado histológico del tumor, la afección ganglionar y el uso de inmunomarcadores de proliferación tumoral, utilizados en conjunto constituyen una herramienta útil en la evaluación de estas pacientes, lo que ofrecería así mejor opción para tratamiento adecuado a casos particulares en un estadio más temprano de la enfermedad.

8th Symposium on Hydrogen, Fuel Cells and Advanced Batteries, Buenos Aires, July 11th-14th, 2022

8th Symposium on Hydrogen, Fuel Cells and Advanced Batteries, Buenos Aires, July 11th-14th, 2022

8th Symposium on Hydrogen, Fuel Cells and Advanced Batteries, Buenos Aires, July 11th-14th, 2022

Trabajo presentado en el 8th Symposium on Hydrogen, Fuel Cells and Advanced Batteries, celebrado en Buenos Aires (Argentina), del 10 al 13 de julio de 2022, Among all types of energy storage systems (ESS), vanadium redox flow batteries (VRFB) stand out for their high efficiency (70-90 %), long life cycle, safety and the possibility to decouple both energy and power sizes [1]. One of the main challenges in the study and analysis of VRFB consists on the correct caracterization of its performance through mathematical models. The importance of developing mathematical models is reflected in the literature, where numerous studies widely validated and referenced can be found, such as the electrochemical model developed by M. Skyllas-Kazacos [2], who pioneered the use of vanadium in redox flow batteries. Models can be classified as static or dynamic, depending on whether the effect of time is taken into acount, and as distributed or lumped parameter models, depending on the space dimension [3]. Tools as COMSOL are used to analyze and develop distributed parameter models, to study effects of flow design, components materials or degradation mechanisms [4]. However, for control purposes, the distributed models are rarely used due to its complexity and relevant computational cost, both in resources and time. For that reason, a vast majority of works in the literature concerning VRFB control, use lumped parameters models. Most of these lumped parameters models use different hypothesis to relax the problem, facilitating its understanding and analysis. This is the case of Skyllas-Kazacos electrochemical models mentioned, where the same flow rate is considered in both semicells,same species concentration inside the cell and tanks, as well as a constant temperature to estimate the open circuit voltage (OCV) by means of the Nernst equation [5]. Therefore, it is necessary to develop an analysis in order to define which variables and parameters will be modelled, and under which assumptions. Thus, in this work, a complete model that considers the most important effects of a VRFB is presented. It can be divided into four submodels, according to the previous parameters, which are: electrochemical, voltage, thermal and hydraulic ones. This model has been developed in a Matlab-Simulink environment as a tool to analyze the performance of a VRFB in a wide range of possibilities, examining the behaviour of the species and the voltage, temperature and pressure variables, incorporating some improvements with respect to other works. For all submodels, a clear distinction is made between both sides of the system (catholyte and anolyte semicells), not only in terms of dimensions and flow rates, but also on the initial conditions., This research is part of the CSIC program for the Spanish Recovery, Transformation and Resilience Plan funded by the Recovery and Resilience Facility of the European Union, established by the Regulation (EU) 2020/2094, CSIC Interdisciplinary Thematic Platform (PTI+) Transición Energética Sostenible+ (PTI-TRANSENER+) and the Spanish Ministry of Economy and Competitiveness under Project DOVELAR (ref. RTI2018-096001-B-C32).