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188 results on '"Monti-Bragadin, C."'

31. Multivariate analysis of antibiograms for typing Pseudomonas aeruginosa.

Author

Giacca, M. and Monti-Bragadin, C.

Abstract

A method for typing Pseudomonas aeruginosa using antibiotic susceptibility patterns is presented, which allows recognition of clusters of the same strain among clinical isolates from different patients, thus indicating whether cross infection has occurred. An index of similarity (the euclidean or the oblique distance), which includes all the differences of disk zone sizes among isolates, is computed and then elaborated by a clustering algorithm that successively groups all the isolates in larger clusters. The results of clustering are presented as dendrograms, whose terminal branches are pruned down to a level below which differences are casual; isolates that still appear on a common branch are considered identical. The reliability of this technique for detecting nosocomial cross infections was assessed by comparing its results with that of serotyping and pyocin typing. Only 2 of 31 (6.4%) clusters detected by multivariate analysis were not confirmed, while 4 of 33 (12.1%) clusters were recognized by serotyping and pyocin typing, but not by multivariate analysis. In at least two instances the differences in susceptibility patterns were due to cytoplasmic R factors. The routine use of antibiogram data for typing purposes should be considered an essential part of nosocomial infection control. [ABSTRACT FROM AUTHOR]

Published
1987
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43. Improved reactivity of hepatitis C virus core protein epitopes in a conformational antigen-presenting system.

Author

Buratti, E, Di Michele, M, Song, P, Monti-Bragadin, C, Scodeller, E A, Baralle, F E, and Tisminetzky, S G

Abstract

Recent studies have identified several epitopes in the N-terminal portion of the nucleocapsid protein which are predominantly recognized by sera of patients infected with hepatitis C virus (HCV). The characterization of the sequences recognized by theses antibodies and the evaluation of their reactivities have been performed mainly with synthetic peptides. However, synthetic peptides are notoriously unreliable as antigens when the immune response is directed against conformational epitopes. In order to improve the detection of antibody responses in HCV-infected patients, we have evaluated the reactivities of three immunodominant regions of the HCV core protein (residues 1 to 20, 21 to 40, and 32 to 46) displayed in a conformation-specific manner on the surface of the Flock House virus (FHV) capsid protein. The results obtained with these proteins in the analysis of 94 serum samples positive by anti-HCV enzyme-linked immunosorbent assay where then compared with those obtained with the corresponding synthetic peptides. The sequence most reactive both with the peptide and with the FHV protein was the region from residues 1 to 20, confirming the low conformational requirements for the display of these residues. On the other hand, the already reported conformational nature of residues 32 to 46 is in keeping with its observed high reactivity when displayed by the FHV recombinant protein and with the low reactivity displayed by its corresponding synthetic peptide. Finally, the high reactivity observed for the chimeric protein displaying the region from residues 21 to 40, as opposed to the results obtained with the synthetic peptide, also suggests that this sequence contains one or more conformational epitopes whose structures cannot be mimicked correctly with synthetic peptides.

Published
1997

44. Expression of the plasmid pKM101-determined DNA repair system in recA− and lex− strains of Escherichia coli

Author

Monti-Bragadin, C., Babudri, N., and Samer, L.

Abstract

pKM101, a plasmid R factor of the N compatibility group increases methylmethane sulfonate mutagenesis and diminishes UV-killing in recA+lex+ and recA+lex- strains, but not in recA-lex+ strains. The induction of a “reclex” dependent colicin is not present in lex- strains carrying the pKM101 factor. These facts indicate that pKM101 acts through an error-prone DNA repair system, which is recA+ dependent, but not lex+ dependent.

Published
1976
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45. Compatibility of pTM89, a new F-like R factor, and of derivative plasmids

Author

Monti-Bragadin, C and Samer, L

Abstract

pTM89, an fi+ R factor that controls the production of repressed F-type pili, is incompatible with plasmids belonging to the FII and P groups. The results of P1 transduction show that all of the resistance markers of pTM89 are part of a single replicon, which also includes RTF. When the compatibility of different derivative plasmids was investigated, it was found that they fall into two classes. Those of the first class have lost the compatibility of pTM89 for the P group but are still incompatible with FII group, whereas those of the second class are compatible with plasmids of both groups. Plasmids of the latter class that are also compatible with each other and, therefore, apparently lack any determinant for compatibility are genetically stable and self-transmissible. It appears, therefore, that compatibility between plasmids cannot be explained by the hypothesis of competition for a maintenance site.

Published
1975
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46. Antimycobacterial activity of N1-[1-[3-aryl-1-(pyridin-2-, 3- or 4-yl)-3-oxo] propyl]-2-pyridinecarboxamidrazones.

Author

Banfi, E., Mamolo, M. G., Zampieri, D., Vio, L., Bragadin, C. Monti, and Monti Bragadin, C

Abstract

Infections caused by non-tuberculous mycobacteria and multidrug-resistant Mycobacterium tuberculosis are difficult to treat, and so new compounds potentially active against these bacteria are being sought. A series of 2-pyridinecarboxamidrazone derivatives, recently synthesized, have been evaluated for their inhibitory activity against 17 Mycobacterium avium isolates; the agar dilution method showed different degrees of susceptibility to the new molecules. Four molecules, three of which are chlorine derivatives, inhibited 94% of the strains tested with an MIC of 32 mg/L. These data indicate that these new pyridine-2-carboxamidrazones merit further study as antimycobacterial agents. [ABSTRACT FROM AUTHOR]

Published
2001
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48. Chemical, biological and antitumor properties of ruthenium-dimethylsulfoxide complexes

Author

Mestroni, G., Alessio, Enzo, Calligaris, M., Attia, W. M., Quadrifoglio, F., Cauci, S., Sava, Gianni, Zorzet, Sonia, Pacor, Sabrina, MONTI BRAGADIN, C., Tamaro, M., Dolzani, Lucilla, AUTORI VARI, G., Mestroni, Alessio, Enzo, M., Calligari, W. M., Attia, F., Quadrifoglio, S., Cauci, Sava, Gianni, Zorzet, Sonia, Pacor, Sabrina, C., MONTI BRAGADIN, M., Tamaro, and Dolzani, Lucilla

Subjects
metal anticancer compounds, ruthenium, DNA, metal anticancer compound
Published
1989

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